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determine the effects of cold stress, mice were fasted for 18 h and placed in 4 °C environment for a 3-h period. The MCAD−/− mice were significantly compromised within this short period of cold stress, some severe enough to result in fatalities. After 1 h of the cold challenge, the average rectal temperature of MCAD−/− mice (n = 5) was 23.4 °C as compared with 35 °C for MCAD+/+ mice (n = 4). Rectal temperatures declined to unrecoverable temperatures of 16.7–19.2 °C in three of the five MCAD−/− mice. By the end of the 1.5-h mark, the two surviving MCAD−/− mice averaged 22.7 °C. In contrast, all four MCAD+/+ mice survived the 3-h cold stress, ending with an average rectal temperature of 33.6 °C."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T2820","span":{"begin":675,"end":681},"obj":"UBERON:0001052"},{"id":"T2819","span":{"begin":617,"end":621},"obj":"NCBITaxon:10088"},{"id":"T2818","span":{"begin":564,"end":568},"obj":"NCBITaxon:10088"},{"id":"T2817","span":{"begin":502,"end":506},"obj":"NCBITaxon:10088"},{"id":"T2816","span":{"begin":398,"end":404},"obj":"UBERON:0001052"},{"id":"T2815","span":{"begin":384,"end":388},"obj":"NCBITaxon:10088"},{"id":"T2814","span":{"begin":324,"end":328},"obj":"NCBITaxon:10088"},{"id":"T2813","span":{"begin":294,"end":300},"obj":"UBERON:0001052"},{"id":"T2812","span":{"begin":128,"end":132},"obj":"NCBITaxon:10088"},{"id":"T2811","span":{"begin":41,"end":45},"obj":"NCBITaxon:10088"}],"text":"To determine the effects of cold stress, mice were fasted for 18 h and placed in 4 °C environment for a 3-h period. The MCAD−/− mice were significantly compromised within this short period of cold stress, some severe enough to result in fatalities. After 1 h of the cold challenge, the average rectal temperature of MCAD−/− mice (n = 5) was 23.4 °C as compared with 35 °C for MCAD+/+ mice (n = 4). Rectal temperatures declined to unrecoverable temperatures of 16.7–19.2 °C in three of the five MCAD−/− mice. By the end of the 1.5-h mark, the two surviving MCAD−/− mice averaged 22.7 °C. In contrast, all four MCAD+/+ mice survived the 3-h cold stress, ending with an average rectal temperature of 33.6 °C."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T2864","span":{"begin":675,"end":681},"obj":"UBERON:0001052"},{"id":"T2863","span":{"begin":617,"end":621},"obj":"NCBITaxon:10088"},{"id":"T2862","span":{"begin":615,"end":616},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T2861","span":{"begin":613,"end":614},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T2860","span":{"begin":609,"end":613},"obj":"GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase"},{"id":"T2859","span":{"begin":564,"end":568},"obj":"NCBITaxon:10088"},{"id":"T2858","span":{"begin":562,"end":563},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T2857","span":{"begin":560,"end":561},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T2856","span":{"begin":556,"end":560},"obj":"GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase"},{"id":"T2855","span":{"begin":502,"end":506},"obj":"NCBITaxon:10088"},{"id":"T2854","span":{"begin":500,"end":501},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T2853","span":{"begin":498,"end":499},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T2852","span":{"begin":494,"end":498},"obj":"GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase"},{"id":"T2851","span":{"begin":398,"end":404},"obj":"UBERON:0001052"},{"id":"T2850","span":{"begin":384,"end":388},"obj":"NCBITaxon:10088"},{"id":"T2849","span":{"begin":382,"end":383},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T2848","span":{"begin":380,"end":381},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T2847","span":{"begin":376,"end":380},"obj":"GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase"},{"id":"T2846","span":{"begin":324,"end":328},"obj":"NCBITaxon:10088"},{"id":"T2845","span":{"begin":322,"end":323},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T2844","span":{"begin":320,"end":321},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T2843","span":{"begin":316,"end":320},"obj":"GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase"},{"id":"T2842","span":{"begin":294,"end":300},"obj":"UBERON:0001052"},{"id":"T2841","span":{"begin":237,"end":247},"obj":"GO_EXT:fatality_or_lethality"},{"id":"T2840","span":{"begin":128,"end":132},"obj":"NCBITaxon:10088"},{"id":"T2839","span":{"begin":126,"end":127},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T2838","span":{"begin":124,"end":125},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T2837","span":{"begin":120,"end":124},"obj":"GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase"},{"id":"T2836","span":{"begin":41,"end":45},"obj":"NCBITaxon:10088"}],"text":"To determine the effects of cold stress, mice were fasted for 18 h and placed in 4 °C environment for a 3-h period. The MCAD−/− mice were significantly compromised within this short period of cold stress, some severe enough to result in fatalities. After 1 h of the cold challenge, the average rectal temperature of MCAD−/− mice (n = 5) was 23.4 °C as compared with 35 °C for MCAD+/+ mice (n = 4). Rectal temperatures declined to unrecoverable temperatures of 16.7–19.2 °C in three of the five MCAD−/− mice. By the end of the 1.5-h mark, the two surviving MCAD−/− mice averaged 22.7 °C. In contrast, all four MCAD+/+ mice survived the 3-h cold stress, ending with an average rectal temperature of 33.6 °C."}