PMC:1189074 / 0-824
Annnotations
craft-sa-dev
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T78 | 222-227 | JJ | denotes | fatty |
| T79 | 228-232 | NN | denotes | acid |
| T80 | 233-234 | NN | denotes | β |
| T81 | 234-235 | HYPH | denotes | - |
| T82 | 245-247 | IN | denotes | in |
| T83 | 248-254 | NNS | denotes | humans |
| T84 | 254-255 | . | denotes | . |
| T85 | 255-415 | sentence | denotes | To better understand the pathogenesis of this disease, we developed a mouse model for MCAD deficiency (MCAD−/−) by gene targeting in embryonic stem (ES) cells. |
| T86 | 256-258 | TO | denotes | To |
| T87 | 266-276 | VB | denotes | understand |
| T88 | 259-265 | RBR | denotes | better |
| T89 | 314-323 | VBD | denotes | developed |
| T90 | 277-280 | DT | denotes | the |
| T91 | 281-293 | NN | denotes | pathogenesis |
| T92 | 294-296 | IN | denotes | of |
| T93 | 297-301 | DT | denotes | this |
| T94 | 302-309 | NN | denotes | disease |
| T95 | 309-311 | , | denotes | , |
| T96 | 311-313 | PRP | denotes | we |
| T97 | 324-325 | DT | denotes | a |
| T98 | 332-337 | NN | denotes | model |
| T99 | 326-331 | NN | denotes | mouse |
| T100 | 338-341 | IN | denotes | for |
| T101 | 342-346 | NN | denotes | MCAD |
| T102 | 347-357 | NN | denotes | deficiency |
| T103 | 358-359 | -LRB- | denotes | ( |
| T104 | 359-363 | NN | denotes | MCAD |
| T105 | 363-364 | SYM | denotes | − |
| T106 | 364-365 | HYPH | denotes | / |
| T107 | 365-366 | SYM | denotes | − |
| T108 | 366-367 | -RRB- | denotes | ) |
| T109 | 368-370 | IN | denotes | by |
| T110 | 371-375 | NN | denotes | gene |
| T111 | 376-385 | NN | denotes | targeting |
| T112 | 386-388 | IN | denotes | in |
| T113 | 389-398 | JJ | denotes | embryonic |
| T114 | 399-403 | NN | denotes | stem |
| T115 | 409-414 | NNS | denotes | cells |
| T116 | 404-405 | -LRB- | denotes | ( |
| T117 | 405-407 | NN | denotes | ES |
| T118 | 407-408 | -RRB- | denotes | ) |
| T119 | 414-415 | . | denotes | . |
| T120 | 415-544 | sentence | denotes | The MCAD−/− mice developed an organic aciduria and fatty liver, and showed profound cold intolerance at 4 °C with prior fasting. |
| T121 | 416-419 | DT | denotes | The |
| T152 | 609-617 | VBN | denotes | reported |
| T153 | 574-578 | VBN | denotes | seen |
| T154 | 579-581 | IN | denotes | in |
| T155 | 582-586 | NN | denotes | MCAD |
| T156 | 590-594 | NNS | denotes | mice |
| T157 | 586-587 | SYM | denotes | − |
| T158 | 587-588 | HYPH | denotes | / |
| T159 | 588-589 | SYM | denotes | − |
| T160 | 595-599 | VBP | denotes | have |
| T161 | 600-603 | RB | denotes | not |
| T162 | 604-608 | VBN | denotes | been |
| T163 | 618-620 | IN | denotes | in |
| T164 | 621-626 | JJ | denotes | human |
| T165 | 632-640 | NNS | denotes | patients |
| T166 | 627-631 | NN | denotes | MCAD |
| T167 | 640-641 | . | denotes | . |
| T168 | 641-800 | sentence | denotes | There was significant neonatal mortality of MCAD−/− pups demonstrating similarities to patterns of clinical episodes and mortality in MCAD-deficient patients. |
| T169 | 642-647 | EX | denotes | There |
| T170 | 648-651 | VBD | denotes | was |
| T171 | 652-663 | JJ | denotes | significant |
| T172 | 673-682 | NN | denotes | mortality |
| T173 | 664-672 | JJ | denotes | neonatal |
| T174 | 683-685 | IN | denotes | of |
| T175 | 686-690 | NN | denotes | MCAD |
| T176 | 694-698 | NNS | denotes | pups |
| T177 | 690-691 | SYM | denotes | − |
| T178 | 691-692 | HYPH | denotes | / |
| T179 | 692-693 | SYM | denotes | − |
| T180 | 699-712 | VBG | denotes | demonstrating |
| T181 | 713-725 | NNS | denotes | similarities |
| T182 | 726-728 | IN | denotes | to |
| T183 | 729-737 | NNS | denotes | patterns |
| T184 | 738-740 | IN | denotes | of |
| T185 | 741-749 | JJ | denotes | clinical |
| T186 | 750-758 | NNS | denotes | episodes |
| T187 | 759-762 | CC | denotes | and |
| T188 | 763-772 | NN | denotes | mortality |
| T189 | 773-775 | IN | denotes | in |
| T190 | 776-780 | NN | denotes | MCAD |
| T191 | 781-790 | JJ | denotes | deficient |
| T192 | 780-781 | HYPH | denotes | - |
| T193 | 791-799 | NNS | denotes | patients |
| T194 | 799-800 | . | denotes | . |
| T196 | 801-804 | DT | denotes | The |
| T198 | 805-809 | NN | denotes | MCAD |
| T199 | 810-819 | JJ | denotes | deficient |
| T200 | 809-810 | HYPH | denotes | - |
| T43 | 0-6 | JJ | denotes | Medium |
| T44 | 7-12 | NN | denotes | Chain |
| T45 | 0-68 | sentence | denotes | Medium-Chain Acyl-CoA Dehydrogenase Deficiency in Gene-Targeted Mice |
| T46 | 6-7 | HYPH | denotes | - |
| T47 | 22-35 | NN | denotes | Dehydrogenase |
| T48 | 13-17 | NN | denotes | Acyl |
| T49 | 18-21 | NN | denotes | CoA |
| T50 | 17-18 | HYPH | denotes | - |
| T51 | 36-46 | NN | denotes | Deficiency |
| T52 | 47-49 | IN | denotes | in |
| T53 | 50-54 | NN | denotes | Gene |
| T54 | 55-63 | VBN | denotes | Targeted |
| T55 | 54-55 | HYPH | denotes | - |
| T56 | 64-68 | NNS | denotes | Mice |
| T57 | 68-255 | sentence | denotes | MCAD Gene Disruption in the Mouse Abstract Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is the most common inherited disorder of mitochondrial fatty acid β-oxidation in humans. |
| T58 | 69-119 | JJ | denotes | MCAD Gene Disruption in the Mouse Abstract Medium |
| T59 | 120-125 | NN | denotes | chain |
| T60 | 119-120 | HYPH | denotes | - |
| T61 | 135-148 | NN | denotes | dehydrogenase |
| T62 | 126-130 | NN | denotes | acyl |
| T63 | 131-134 | NN | denotes | CoA |
| T64 | 130-131 | HYPH | denotes | - |
| T65 | 156-166 | NN | denotes | deficiency |
| T66 | 149-150 | -LRB- | denotes | ( |
| T67 | 150-154 | NN | denotes | MCAD |
| T68 | 154-155 | -RRB- | denotes | ) |
| T69 | 167-169 | VBZ | denotes | is |
| T70 | 170-173 | DT | denotes | the |
| T71 | 196-204 | NN | denotes | disorder |
| T72 | 174-178 | RBS | denotes | most |
| T73 | 179-185 | JJ | denotes | common |
| T74 | 186-195 | VBN | denotes | inherited |
| T75 | 205-207 | IN | denotes | of |
| T76 | 208-221 | JJ | denotes | mitochondrial |
| T77 | 235-244 | NN | denotes | oxidation |
| T122 | 428-432 | NNS | denotes | mice |
| T123 | 420-424 | NN | denotes | MCAD |
| T124 | 424-425 | SYM | denotes | − |
| T125 | 425-426 | HYPH | denotes | / |
| T126 | 426-427 | SYM | denotes | − |
| T127 | 433-442 | VBD | denotes | developed |
| T128 | 443-445 | DT | denotes | an |
| T129 | 454-462 | NN | denotes | aciduria |
| T130 | 446-453 | JJ | denotes | organic |
| T131 | 463-466 | CC | denotes | and |
| T132 | 467-472 | JJ | denotes | fatty |
| T133 | 473-478 | NN | denotes | liver |
| T134 | 478-480 | , | denotes | , |
| T135 | 480-483 | CC | denotes | and |
| T136 | 484-490 | VBD | denotes | showed |
| T137 | 491-499 | JJ | denotes | profound |
| T138 | 505-516 | NN | denotes | intolerance |
| T139 | 500-504 | NN | denotes | cold |
| T140 | 517-519 | IN | denotes | at |
| T141 | 520-521 | CD | denotes | 4 |
| T142 | 522-524 | NN | denotes | °C |
| T143 | 525-529 | IN | denotes | with |
| T144 | 530-535 | JJ | denotes | prior |
| T145 | 536-543 | NN | denotes | fasting |
| T146 | 543-544 | . | denotes | . |
| T147 | 544-641 | sentence | denotes | The sporadic cardiac lesions seen in MCAD−/− mice have not been reported in human MCAD patients. |
| T148 | 545-548 | DT | denotes | The |
| T149 | 566-573 | NNS | denotes | lesions |
| T150 | 549-557 | JJ | denotes | sporadic |
| T151 | 558-565 | JJ | denotes | cardiac |
| R74 | T187 | T186 | cc | and,episodes |
| R75 | T188 | T186 | conj | mortality,episodes |
| R76 | T189 | T183 | prep | in,patterns |
| R1 | T78 | T79 | amod | fatty,acid |
| R2 | T79 | T77 | compound | acid,oxidation |
| R3 | T80 | T77 | compound | β,oxidation |
| R4 | T81 | T77 | punct | -,oxidation |
| R5 | T82 | T69 | prep | in,is |
| R6 | T83 | T82 | pobj | humans,in |
| R7 | T84 | T69 | punct | .,is |
| R8 | T86 | T87 | aux | To,understand |
| R9 | T87 | T89 | advcl | understand,developed |
| R10 | T88 | T87 | advmod | better,understand |
| R11 | T90 | T91 | det | the,pathogenesis |
| R12 | T91 | T87 | dobj | pathogenesis,understand |
| R13 | T92 | T91 | prep | of,pathogenesis |
| R14 | T93 | T94 | det | this,disease |
| R15 | T94 | T92 | pobj | disease,of |
| R16 | T95 | T89 | punct | ", ",developed |
| R17 | T96 | T89 | nsubj | we,developed |
| R18 | T97 | T98 | det | a,model |
| R19 | T98 | T89 | dobj | model,developed |
| R20 | T99 | T98 | compound | mouse,model |
| R21 | T100 | T98 | prep | for,model |
| R22 | T101 | T102 | compound | MCAD,deficiency |
| R23 | T102 | T100 | pobj | deficiency,for |
| R24 | T103 | T102 | punct | (,deficiency |
| R25 | T104 | T102 | appos | MCAD,deficiency |
| R26 | T105 | T104 | punct | −,MCAD |
| R27 | T106 | T104 | punct | /,MCAD |
| R28 | T107 | T104 | punct | −,MCAD |
| R29 | T108 | T89 | punct | ),developed |
| R30 | T109 | T89 | prep | by,developed |
| R31 | T110 | T111 | compound | gene,targeting |
| R32 | T111 | T109 | pobj | targeting,by |
| R33 | T112 | T111 | prep | in,targeting |
| R34 | T113 | T114 | amod | embryonic,stem |
| R35 | T114 | T115 | nmod | stem,cells |
| R36 | T115 | T112 | pobj | cells,in |
| R37 | T116 | T114 | punct | (,stem |
| R38 | T117 | T114 | appos | ES,stem |
| R39 | T118 | T115 | punct | ),cells |
| R40 | T119 | T89 | punct | .,developed |
| R41 | T121 | T122 | det | The,mice |
| R42 | T153 | T149 | acl | seen,lesions |
| R43 | T154 | T153 | prep | in,seen |
| R44 | T155 | T156 | nmod | MCAD,mice |
| R45 | T156 | T154 | pobj | mice,in |
| R46 | T157 | T155 | punct | −,MCAD |
| R47 | T158 | T155 | punct | /,MCAD |
| R48 | T159 | T155 | punct | −,MCAD |
| R49 | T160 | T152 | aux | have,reported |
| R50 | T161 | T152 | neg | not,reported |
| R51 | T162 | T152 | auxpass | been,reported |
| R52 | T163 | T152 | prep | in,reported |
| R53 | T164 | T165 | amod | human,patients |
| R54 | T165 | T163 | pobj | patients,in |
| R55 | T166 | T165 | compound | MCAD,patients |
| R56 | T167 | T152 | punct | .,reported |
| R57 | T169 | T170 | expl | There,was |
| R58 | T171 | T172 | amod | significant,mortality |
| R59 | T172 | T170 | attr | mortality,was |
| R60 | T173 | T172 | amod | neonatal,mortality |
| R61 | T174 | T172 | prep | of,mortality |
| R62 | T175 | T176 | nmod | MCAD,pups |
| R63 | T176 | T174 | pobj | pups,of |
| R64 | T177 | T175 | punct | −,MCAD |
| R65 | T178 | T175 | punct | /,MCAD |
| R66 | T179 | T175 | punct | −,MCAD |
| R67 | T180 | T172 | acl | demonstrating,mortality |
| R68 | T181 | T180 | dobj | similarities,demonstrating |
| R69 | T182 | T181 | prep | to,similarities |
| R70 | T183 | T182 | pobj | patterns,to |
| R71 | T184 | T183 | prep | of,patterns |
| R72 | T185 | T186 | amod | clinical,episodes |
| R73 | T186 | T184 | pobj | episodes,of |
| R77 | T190 | T191 | npadvmod | MCAD,deficient |
| R78 | T191 | T193 | amod | deficient,patients |
| R79 | T192 | T191 | punct | -,deficient |
| R80 | T193 | T189 | pobj | patients,in |
| R81 | T194 | T170 | punct | .,was |
| R84 | T198 | T199 | npadvmod | MCAD,deficient |
| R86 | T200 | T199 | punct | -,deficient |
| R122 | T43 | T44 | amod | Medium,Chain |
| R123 | T44 | T47 | compound | Chain,Dehydrogenase |
| R124 | T46 | T44 | punct | -,Chain |
| R125 | T47 | T51 | compound | Dehydrogenase,Deficiency |
| R126 | T48 | T49 | compound | Acyl,CoA |
| R127 | T49 | T47 | compound | CoA,Dehydrogenase |
| R128 | T50 | T49 | punct | -,CoA |
| R129 | T52 | T51 | prep | in,Deficiency |
| R130 | T53 | T54 | npadvmod | Gene,Targeted |
| R131 | T54 | T56 | amod | Targeted,Mice |
| R132 | T55 | T54 | punct | -,Targeted |
| R133 | T56 | T52 | pobj | Mice,in |
| R134 | T58 | T59 | amod | "MCAD Gene Disruption in the Mouse Abstract Medium",chain |
| R135 | T59 | T61 | nmod | chain,dehydrogenase |
| R136 | T60 | T59 | punct | -,chain |
| R137 | T61 | T65 | nmod | dehydrogenase,deficiency |
| R138 | T62 | T63 | nmod | acyl,CoA |
| R139 | T63 | T61 | nmod | CoA,dehydrogenase |
| R140 | T64 | T63 | punct | -,CoA |
| R141 | T65 | T69 | nsubj | deficiency,is |
| R142 | T66 | T61 | punct | (,dehydrogenase |
| R143 | T67 | T61 | appos | MCAD,dehydrogenase |
| R144 | T68 | T65 | punct | ),deficiency |
| R145 | T70 | T71 | det | the,disorder |
| R146 | T71 | T69 | attr | disorder,is |
| R147 | T72 | T73 | advmod | most,common |
| R148 | T73 | T71 | amod | common,disorder |
| R149 | T74 | T71 | amod | inherited,disorder |
| R150 | T75 | T71 | prep | of,disorder |
| R151 | T76 | T77 | amod | mitochondrial,oxidation |
| R152 | T77 | T75 | pobj | oxidation,of |
| R153 | T122 | T127 | nsubj | mice,developed |
| R154 | T123 | T122 | nmod | MCAD,mice |
| R155 | T124 | T123 | punct | −,MCAD |
| R156 | T125 | T123 | punct | /,MCAD |
| R157 | T126 | T123 | punct | −,MCAD |
| R158 | T128 | T129 | det | an,aciduria |
| R159 | T129 | T127 | dobj | aciduria,developed |
| R160 | T130 | T129 | amod | organic,aciduria |
| R161 | T131 | T129 | cc | and,aciduria |
| R162 | T132 | T133 | amod | fatty,liver |
| R163 | T133 | T129 | conj | liver,aciduria |
| R164 | T134 | T127 | punct | ", ",developed |
| R165 | T135 | T127 | cc | and,developed |
| R166 | T136 | T127 | conj | showed,developed |
| R167 | T137 | T138 | amod | profound,intolerance |
| R168 | T138 | T136 | dobj | intolerance,showed |
| R169 | T139 | T138 | compound | cold,intolerance |
| R170 | T140 | T136 | prep | at,showed |
| R171 | T141 | T142 | nummod | 4,°C |
| R172 | T142 | T140 | pobj | °C,at |
| R173 | T143 | T136 | prep | with,showed |
| R174 | T144 | T145 | amod | prior,fasting |
| R175 | T145 | T143 | pobj | fasting,with |
| R176 | T146 | T127 | punct | .,developed |
| R177 | T148 | T149 | det | The,lesions |
| R178 | T149 | T152 | nsubjpass | lesions,reported |
| R179 | T150 | T149 | amod | sporadic,lesions |
| R180 | T151 | T149 | amod | cardiac,lesions |
craft-ca-core-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T242 | 326-331 | NCBITaxon:10088 | denotes | mouse |
| T243 | 371-375 | SO:0000704 | denotes | gene |
| T244 | 389-398 | UBERON:0000922 | denotes | embryonic |
| T245 | 389-403 | _FRAGMENT | denotes | embryonic stem |
| T246 | 409-414 | CL:0002322 | denotes | cells |
| T247 | 405-407 | _FRAGMENT | denotes | ES |
| T248 | 428-432 | NCBITaxon:10088 | denotes | mice |
| T249 | 473-478 | UBERON:0002107 | denotes | liver |
| T250 | 558-565 | UBERON:0000948 | denotes | cardiac |
| T251 | 590-594 | NCBITaxon:10088 | denotes | mice |
| T252 | 621-626 | NCBITaxon:9606 | denotes | human |
| T233 | 0-21 | CHEBI:61907 | denotes | Medium-Chain Acyl-CoA |
| T234 | 50-54 | SO:0000704 | denotes | Gene |
| T235 | 64-68 | NCBITaxon:10088 | denotes | Mice |
| T236 | 69-134 | CHEBI:61907 | denotes | MCAD Gene Disruption in the Mouse Abstract Medium-chain acyl-CoA |
| T237 | 208-221 | GO:0005739 | denotes | mitochondrial |
| T238 | 222-232 | CHEBI:35366 | denotes | fatty acid |
| T239 | 222-244 | GO:0006635 | denotes | fatty acid β-oxidation |
| T240 | 235-244 | MOP:0000568 | denotes | oxidation |
| T241 | 248-254 | NCBITaxon:9606 | denotes | humans |
| R118 | T246 | T245 | _lexicallyChainedTo | cells,embryonic stem |
| R119 | T246 | T247 | _lexicallyChainedTo | cells,ES |
craft-ca-core-ex-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T262 | 0-21 | CHEBI:61907 | denotes | Medium-Chain Acyl-CoA |
| T263 | 0-35 | GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase | denotes | Medium-Chain Acyl-CoA Dehydrogenase |
| T264 | 50-54 | SO_EXT:0000704 | denotes | Gene |
| T265 | 64-68 | NCBITaxon:10088 | denotes | Mice |
| T266 | 69-134 | CHEBI:61907 | denotes | MCAD Gene Disruption in the Mouse Abstract Medium-chain acyl-CoA |
| T267 | 69-148 | GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase | denotes | MCAD Gene Disruption in the Mouse Abstract Medium-chain acyl-CoA dehydrogenase |
| T268 | 150-154 | GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase | denotes | MCAD |
| T269 | 208-221 | GO:0005739 | denotes | mitochondrial |
| T270 | 222-227 | CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue | denotes | fatty |
| T271 | 222-232 | CHEBI:35366 | denotes | fatty acid |
| T272 | 222-244 | GO:0006635 | denotes | fatty acid β-oxidation |
| T273 | 235-244 | MOP:0000568 | denotes | oxidation |
| T274 | 248-254 | NCBITaxon:9606 | denotes | humans |
| T275 | 326-331 | NCBITaxon:10088 | denotes | mouse |
| T276 | 342-346 | GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase | denotes | MCAD |
| T277 | 359-363 | GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase | denotes | MCAD |
| T278 | 363-364 | SO_EXT:sequence_nullness_or_absence | denotes | − |
| T279 | 365-366 | SO_EXT:sequence_nullness_or_absence | denotes | − |
| T280 | 371-375 | SO_EXT:0000704 | denotes | gene |
| T281 | 389-398 | UBERON:0000922 | denotes | embryonic |
| T282 | 389-403 | _FRAGMENT | denotes | embryonic stem |
| T283 | 409-414 | CL:0002322 | denotes | cells |
| T284 | 405-407 | _FRAGMENT | denotes | ES |
| T285 | 409-414 | CL_GO_EXT:cell | denotes | cells |
| T286 | 420-424 | GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase | denotes | MCAD |
| T287 | 424-425 | SO_EXT:sequence_nullness_or_absence | denotes | − |
| T288 | 426-427 | SO_EXT:sequence_nullness_or_absence | denotes | − |
| T289 | 428-432 | NCBITaxon:10088 | denotes | mice |
| T290 | 467-472 | CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue | denotes | fatty |
| T291 | 473-478 | UBERON:0002107 | denotes | liver |
| T292 | 558-565 | UBERON:0000948 | denotes | cardiac |
| T293 | 582-586 | GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase | denotes | MCAD |
| T294 | 586-587 | SO_EXT:sequence_nullness_or_absence | denotes | − |
| T295 | 588-589 | SO_EXT:sequence_nullness_or_absence | denotes | − |
| T296 | 590-594 | NCBITaxon:10088 | denotes | mice |
| T297 | 621-626 | NCBITaxon:9606 | denotes | human |
| T298 | 627-631 | GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase | denotes | MCAD |
| T299 | 664-672 | PATO_UBERON_EXT:neonate_or_newborn | denotes | neonatal |
| T300 | 686-690 | GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase | denotes | MCAD |
| T301 | 690-691 | SO_EXT:sequence_nullness_or_absence | denotes | − |
| T302 | 692-693 | SO_EXT:sequence_nullness_or_absence | denotes | − |
| T303 | 694-698 | NCBITaxon_UBERON_EXT:pup | denotes | pups |
| T304 | 776-780 | GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase | denotes | MCAD |
| T305 | 805-809 | GO_PR_EXT:medium_chain_acyl_CoA_dehydrogenase | denotes | MCAD |
| R120 | T283 | T282 | _lexicallyChainedTo | cells,embryonic stem |
| R121 | T283 | T284 | _lexicallyChainedTo | cells,ES |