Id |
Subject |
Object |
Predicate |
Lexical cue |
T9304 |
5-12 |
VBP |
denotes |
produce |
T9316 |
0-4 |
NNS |
denotes |
mice |
T9317 |
13-17 |
RB |
denotes |
very |
T9318 |
18-24 |
JJ |
denotes |
dilute |
T9319 |
25-30 |
NN |
denotes |
urine |
T9320 |
31-32 |
-LRB- |
denotes |
( |
T9321 |
32-38 |
NN |
denotes |
Figure |
T9322 |
39-41 |
CD |
denotes |
1D |
T9323 |
41-42 |
-RRB- |
denotes |
) |
T9324 |
42-43 |
. |
denotes |
. |
T9325 |
43-163 |
sentence |
denotes |
Basal urine concentration in mutant mice is about 161 mOsm, compared to about 1,293 mOsm in wild-type mice (p < 0.001). |
T9326 |
44-49 |
JJ |
denotes |
Basal |
T9327 |
56-69 |
NN |
denotes |
concentration |
T9328 |
50-55 |
NN |
denotes |
urine |
T9329 |
85-87 |
VBZ |
denotes |
is |
T9330 |
70-72 |
IN |
denotes |
in |
T9331 |
73-79 |
NN |
denotes |
mutant |
T9332 |
80-84 |
NNS |
denotes |
mice |
T9333 |
88-93 |
RB |
denotes |
about |
T9334 |
94-97 |
CD |
denotes |
161 |
T9335 |
98-102 |
NN |
denotes |
mOsm |
T9336 |
102-104 |
, |
denotes |
, |
T9337 |
104-112 |
VBN |
denotes |
compared |
T9338 |
113-115 |
IN |
denotes |
to |
T9339 |
116-121 |
IN |
denotes |
about |
T9340 |
122-127 |
CD |
denotes |
1,293 |
T9341 |
128-132 |
NN |
denotes |
mOsm |
T9342 |
133-135 |
IN |
denotes |
in |
T9343 |
136-140 |
JJ |
denotes |
wild |
T9344 |
141-145 |
NN |
denotes |
type |
T9345 |
140-141 |
HYPH |
denotes |
- |
T9346 |
146-150 |
NNS |
denotes |
mice |
T9347 |
151-152 |
-LRB- |
denotes |
( |
T9348 |
156-161 |
CD |
denotes |
0.001 |
T9349 |
152-153 |
NN |
denotes |
p |
T9350 |
154-155 |
SYM |
denotes |
< |
T9351 |
161-162 |
-RRB- |
denotes |
) |
T9352 |
162-163 |
. |
denotes |
. |
T9353 |
163-306 |
sentence |
denotes |
Normally, urine concentration is under the control of the hypothalamus, which, in response to hypovolemia or hypernatremia [21], secretes AVP. |
T9354 |
164-172 |
RB |
denotes |
Normally |
T9355 |
194-196 |
VBZ |
denotes |
is |
T9356 |
172-174 |
, |
denotes |
, |
T9357 |
174-179 |
NN |
denotes |
urine |
T9358 |
180-193 |
NN |
denotes |
concentration |
T9359 |
197-202 |
IN |
denotes |
under |
T9360 |
203-206 |
DT |
denotes |
the |
T9361 |
207-214 |
NN |
denotes |
control |
T9362 |
215-217 |
IN |
denotes |
of |
T9363 |
218-221 |
DT |
denotes |
the |
T9364 |
222-234 |
NN |
denotes |
hypothalamus |
T9365 |
234-236 |
, |
denotes |
, |
T9366 |
236-241 |
WDT |
denotes |
which |
T9367 |
293-301 |
VBZ |
denotes |
secretes |
T9368 |
241-243 |
, |
denotes |
, |
T9369 |
243-245 |
IN |
denotes |
in |
T9370 |
246-254 |
NN |
denotes |
response |
T9371 |
255-257 |
IN |
denotes |
to |
T9372 |
258-269 |
NN |
denotes |
hypovolemia |
T9373 |
270-272 |
CC |
denotes |
or |
T9374 |
273-286 |
NN |
denotes |
hypernatremia |
T9375 |
287-288 |
-LRB- |
denotes |
[ |
T9376 |
288-290 |
CD |
denotes |
21 |
T9377 |
290-291 |
-RRB- |
denotes |
] |
T9378 |
291-293 |
, |
denotes |
, |
T9379 |
302-305 |
NN |
denotes |
AVP |
T9380 |
305-306 |
. |
denotes |
. |
T9381 |
306-432 |
sentence |
denotes |
The synthetic AVP analog, 1-deamino-8-D-arginine vasopressin (dDAVP; also called desmopressin), is a potent agonist of AVPR2. |
T9382 |
307-310 |
DT |
denotes |
The |
T9383 |
325-331 |
NN |
denotes |
analog |
T9384 |
311-320 |
JJ |
denotes |
synthetic |
T9385 |
321-324 |
NN |
denotes |
AVP |
T9386 |
403-405 |
VBZ |
denotes |
is |
T9387 |
331-333 |
, |
denotes |
, |
T9388 |
333-334 |
CD |
denotes |
1 |
T9389 |
335-342 |
NN |
denotes |
deamino |
T9390 |
334-335 |
HYPH |
denotes |
- |
T9391 |
347-355 |
NN |
denotes |
arginine |
T9392 |
342-343 |
HYPH |
denotes |
- |
T9393 |
343-344 |
CD |
denotes |
8 |
T9394 |
344-345 |
HYPH |
denotes |
- |
T9395 |
345-346 |
NN |
denotes |
D |
T9396 |
346-347 |
HYPH |
denotes |
- |
T9397 |
356-367 |
NN |
denotes |
vasopressin |
T9398 |
368-369 |
-LRB- |
denotes |
( |
T9399 |
369-374 |
NN |
denotes |
dDAVP |
T9400 |
374-375 |
: |
denotes |
; |
T9401 |
376-380 |
RB |
denotes |
also |
T9402 |
381-387 |
VBN |
denotes |
called |
T9403 |
388-400 |
NN |
denotes |
desmopressin |
T9404 |
400-401 |
-RRB- |
denotes |
) |
T9405 |
401-403 |
, |
denotes |
, |
T9406 |
406-407 |
DT |
denotes |
a |
T9407 |
415-422 |
NN |
denotes |
agonist |
T9408 |
408-414 |
JJ |
denotes |
potent |
T9409 |
423-425 |
IN |
denotes |
of |
T9410 |
426-431 |
NN |
denotes |
AVPR2 |
T9411 |
431-432 |
. |
denotes |
. |
T9412 |
432-576 |
sentence |
denotes |
When administered to wild-type mice, dDAVP leads to a dramatic increase in urine concentration, from 1,293 to 5,885 mOsm (4.6-fold; Figure 1D). |
T9413 |
433-437 |
WRB |
denotes |
When |
T9414 |
438-450 |
VBN |
denotes |
administered |
T9415 |
476-481 |
VBZ |
denotes |
leads |
T9416 |
451-453 |
IN |
denotes |
to |
T9417 |
454-458 |
JJ |
denotes |
wild |
T9418 |
459-463 |
NN |
denotes |
type |
T9419 |
458-459 |
HYPH |
denotes |
- |
T9420 |
464-468 |
NNS |
denotes |
mice |
T9421 |
468-470 |
, |
denotes |
, |
T9422 |
470-475 |
NN |
denotes |
dDAVP |
T9423 |
482-484 |
IN |
denotes |
to |
T9424 |
485-486 |
DT |
denotes |
a |
T9425 |
496-504 |
NN |
denotes |
increase |
T9426 |
487-495 |
JJ |
denotes |
dramatic |
T9427 |
505-507 |
IN |
denotes |
in |
T9428 |
508-513 |
NN |
denotes |
urine |
T9429 |
514-527 |
NN |
denotes |
concentration |
T9430 |
527-529 |
, |
denotes |
, |
T9431 |
529-533 |
IN |
denotes |
from |
T9432 |
534-539 |
CD |
denotes |
1,293 |
T9433 |
540-542 |
IN |
denotes |
to |
T9434 |
543-548 |
CD |
denotes |
5,885 |
T9435 |
549-553 |
NN |
denotes |
mOsm |
T9436 |
554-555 |
-LRB- |
denotes |
( |
T9437 |
565-571 |
NN |
denotes |
Figure |
T9438 |
555-563 |
RB |
denotes |
4.6-fold |
T9439 |
563-564 |
: |
denotes |
; |
T9440 |
572-574 |
CD |
denotes |
1D |
T9441 |
574-575 |
-RRB- |
denotes |
) |
T9442 |
575-576 |
. |
denotes |
. |
T9443 |
576-848 |
sentence |
denotes |
With similar treatment, mutant mice concentrate their urine to a lesser but still significant extent, from 161 to 470 mOsm (2.9-fold), indicating that these animals are not only unable to concentrate their urine properly but are also defective in their response to dDAVP. |
T9444 |
577-581 |
IN |
denotes |
With |
T9445 |
613-624 |
VBP |
denotes |
concentrate |
T9446 |
582-589 |
JJ |
denotes |
similar |
T9447 |
590-599 |
NN |
denotes |
treatment |
T9448 |
599-601 |
, |
denotes |
, |
T9449 |
601-607 |
NN |
denotes |
mutant |
T9450 |
608-612 |
NNS |
denotes |
mice |
T9451 |
625-630 |
PRP$ |
denotes |
their |
T9452 |
631-636 |
NN |
denotes |
urine |
T9453 |
637-639 |
IN |
denotes |
to |
T9454 |
640-641 |
DT |
denotes |
a |
T9455 |
671-677 |
NN |
denotes |
extent |
T9456 |
642-648 |
JJR |
denotes |
lesser |
T9457 |
649-652 |
CC |
denotes |
but |
T9458 |
653-658 |
RB |
denotes |
still |
T9459 |
659-670 |
JJ |
denotes |
significant |
T9460 |
677-679 |
, |
denotes |
, |
T9461 |
679-683 |
IN |
denotes |
from |
T9462 |
684-687 |
CD |
denotes |
161 |
T9463 |
688-690 |
IN |
denotes |
to |
T9464 |
691-694 |
CD |
denotes |
470 |
T9465 |
695-699 |
NN |
denotes |
mOsm |
T9466 |
700-701 |
-LRB- |
denotes |
( |
T9467 |
701-709 |
RB |
denotes |
2.9-fold |
T9468 |
709-710 |
-RRB- |
denotes |
) |
T9469 |
710-712 |
, |
denotes |
, |
T9470 |
712-722 |
VBG |
denotes |
indicating |
T9471 |
723-727 |
IN |
denotes |
that |
T9472 |
742-745 |
VBP |
denotes |
are |
T9473 |
728-733 |
DT |
denotes |
these |
T9474 |
734-741 |
NNS |
denotes |
animals |
T9475 |
746-749 |
RB |
denotes |
not |
T9476 |
750-754 |
RB |
denotes |
only |
T9477 |
755-761 |
JJ |
denotes |
unable |
T9478 |
762-764 |
TO |
denotes |
to |
T9479 |
765-776 |
VB |
denotes |
concentrate |
T9480 |
777-782 |
PRP$ |
denotes |
their |
T9481 |
783-788 |
NN |
denotes |
urine |
T9482 |
789-797 |
RB |
denotes |
properly |
T9483 |
798-801 |
CC |
denotes |
but |
T9484 |
802-805 |
VBP |
denotes |
are |
T9485 |
806-810 |
RB |
denotes |
also |
T9486 |
811-820 |
JJ |
denotes |
defective |
T9487 |
821-823 |
IN |
denotes |
in |
T9488 |
824-829 |
PRP$ |
denotes |
their |
T9489 |
830-838 |
NN |
denotes |
response |
T9490 |
839-841 |
IN |
denotes |
to |
T9491 |
842-847 |
NN |
denotes |
dDAVP |
T9492 |
847-848 |
. |
denotes |
. |
T9493 |
848-1047 |
sentence |
denotes |
The smaller response to dDAVP indicates some residual activity of the mutant AQP2 channel, which must be sufficient to allow survival of the individual, in contrast to the T126M knock-in mouse [18]. |
T9494 |
849-852 |
DT |
denotes |
The |
T9495 |
861-869 |
NN |
denotes |
response |
T9496 |
853-860 |
JJR |
denotes |
smaller |
T9497 |
879-888 |
VBZ |
denotes |
indicates |
T9498 |
870-872 |
IN |
denotes |
to |
T9499 |
873-878 |
NN |
denotes |
dDAVP |
T9500 |
889-893 |
DT |
denotes |
some |
T9501 |
903-911 |
NN |
denotes |
activity |
T9502 |
894-902 |
JJ |
denotes |
residual |
T9503 |
912-914 |
IN |
denotes |
of |
T9504 |
915-918 |
DT |
denotes |
the |
T9505 |
931-938 |
NN |
denotes |
channel |
T9506 |
919-925 |
NN |
denotes |
mutant |
T9507 |
926-930 |
NN |
denotes |
AQP2 |
T9508 |
938-940 |
, |
denotes |
, |
T9509 |
940-945 |
WDT |
denotes |
which |
T9510 |
951-953 |
VB |
denotes |
be |
T9511 |
946-950 |
MD |
denotes |
must |
T9512 |
954-964 |
JJ |
denotes |
sufficient |
T9513 |
965-967 |
TO |
denotes |
to |
T9514 |
968-973 |
VB |
denotes |
allow |
T9515 |
974-982 |
NN |
denotes |
survival |
T9516 |
983-985 |
IN |
denotes |
of |
T9517 |
986-989 |
DT |
denotes |
the |
T9518 |
990-1000 |
NN |
denotes |
individual |
T9519 |
1000-1002 |
, |
denotes |
, |
T9520 |
1002-1004 |
IN |
denotes |
in |
T9521 |
1005-1013 |
NN |
denotes |
contrast |
T9522 |
1014-1016 |
IN |
denotes |
to |
T9523 |
1017-1020 |
DT |
denotes |
the |
T9524 |
1036-1041 |
NN |
denotes |
mouse |
T9525 |
1021-1026 |
NN |
denotes |
T126M |
T9526 |
1027-1032 |
VB |
denotes |
knock |
T9527 |
1032-1033 |
HYPH |
denotes |
- |
T9528 |
1033-1035 |
RP |
denotes |
in |
T9529 |
1042-1043 |
-LRB- |
denotes |
[ |
T9530 |
1043-1045 |
CD |
denotes |
18 |
T9531 |
1045-1046 |
-RRB- |
denotes |
] |
T9532 |
1046-1047 |
. |
denotes |
. |
T9533 |
1047-1305 |
sentence |
denotes |
Multiple heterozygous matings yielded 101 animals, which appeared at a ratio of 26:49:26, near the expected Mendelian wild type, heterozygote, and mutant frequencies, respectively, indicating that there is no reduced viability associated with this mutation. |
T9534 |
1048-1056 |
JJ |
denotes |
Multiple |
T9535 |
1070-1077 |
NNS |
denotes |
matings |
T9536 |
1057-1069 |
JJ |
denotes |
heterozygous |
T9537 |
1078-1085 |
VBD |
denotes |
yielded |
T9538 |
1086-1089 |
CD |
denotes |
101 |
T9539 |
1090-1097 |
NNS |
denotes |
animals |
T9540 |
1097-1099 |
, |
denotes |
, |
T9541 |
1099-1104 |
WDT |
denotes |
which |
T9542 |
1105-1113 |
VBD |
denotes |
appeared |
T9543 |
1114-1116 |
IN |
denotes |
at |
T9544 |
1117-1118 |
DT |
denotes |
a |
T9545 |
1119-1124 |
NN |
denotes |
ratio |
T9546 |
1125-1127 |
IN |
denotes |
of |
T9547 |
1128-1130 |
CD |
denotes |
26 |
T9548 |
1130-1131 |
SYM |
denotes |
: |
T9549 |
1131-1133 |
CD |
denotes |
49 |
T9550 |
1133-1134 |
SYM |
denotes |
: |
T9551 |
1134-1136 |
CD |
denotes |
26 |
T9552 |
1136-1138 |
, |
denotes |
, |
T9553 |
1138-1142 |
IN |
denotes |
near |
T9554 |
1143-1146 |
DT |
denotes |
the |
T9555 |
1202-1213 |
NNS |
denotes |
frequencies |
T9556 |
1147-1155 |
VBN |
denotes |
expected |
T9557 |
1156-1165 |
JJ |
denotes |
Mendelian |
T9558 |
1171-1175 |
NN |
denotes |
type |
T9559 |
1166-1170 |
JJ |
denotes |
wild |
T9560 |
1175-1177 |
, |
denotes |
, |
T9561 |
1177-1189 |
NN |
denotes |
heterozygote |
T9562 |
1189-1191 |
, |
denotes |
, |
T9563 |
1191-1194 |
CC |
denotes |
and |
T9564 |
1195-1201 |
NN |
denotes |
mutant |
T9565 |
1213-1215 |
, |
denotes |
, |
T9566 |
1215-1227 |
RB |
denotes |
respectively |
T9567 |
1227-1229 |
, |
denotes |
, |
T9568 |
1229-1239 |
VBG |
denotes |
indicating |
T9569 |
1240-1244 |
IN |
denotes |
that |
T9570 |
1251-1253 |
VBZ |
denotes |
is |
T9571 |
1245-1250 |
EX |
denotes |
there |
T9572 |
1254-1256 |
DT |
denotes |
no |
T9573 |
1265-1274 |
NN |
denotes |
viability |
T9574 |
1257-1264 |
VBN |
denotes |
reduced |
T9575 |
1275-1285 |
VBN |
denotes |
associated |
T9576 |
1286-1290 |
IN |
denotes |
with |
T9577 |
1291-1295 |
DT |
denotes |
this |
T9578 |
1296-1304 |
NN |
denotes |
mutation |
T9579 |
1304-1305 |
. |
denotes |
. |
T9580 |
1305-1488 |
sentence |
denotes |
Other than the increased urine production and water intake, there was no overt phenotype in mutant mice, save distended kidneys, which appeared variably in adult animals (Figure 2A). |
T9581 |
1306-1311 |
JJ |
denotes |
Other |
T9582 |
1372-1375 |
VBD |
denotes |
was |
T9583 |
1312-1316 |
IN |
denotes |
than |
T9584 |
1317-1320 |
DT |
denotes |
the |
T9585 |
1337-1347 |
NN |
denotes |
production |
T9586 |
1321-1330 |
VBN |
denotes |
increased |
T9587 |
1331-1336 |
NN |
denotes |
urine |
T9588 |
1348-1351 |
CC |
denotes |
and |
T9589 |
1352-1357 |
NN |
denotes |
water |
T9590 |
1358-1364 |
NN |
denotes |
intake |
T9591 |
1364-1366 |
, |
denotes |
, |
T9592 |
1366-1371 |
EX |
denotes |
there |
T9593 |
1376-1378 |
DT |
denotes |
no |
T9594 |
1385-1394 |
NN |
denotes |
phenotype |
T9595 |
1379-1384 |
JJ |
denotes |
overt |
T9596 |
1395-1397 |
IN |
denotes |
in |
T9597 |
1398-1404 |
NN |
denotes |
mutant |
T9598 |
1405-1409 |
NNS |
denotes |
mice |
T9599 |
1409-1411 |
, |
denotes |
, |
T9600 |
1411-1415 |
IN |
denotes |
save |
T9601 |
1416-1425 |
JJ |
denotes |
distended |
T9602 |
1426-1433 |
NNS |
denotes |
kidneys |
T9603 |
1433-1435 |
, |
denotes |
, |
T9604 |
1435-1440 |
WDT |
denotes |
which |
T9605 |
1441-1449 |
VBD |
denotes |
appeared |
T9606 |
1450-1458 |
RB |
denotes |
variably |
T9607 |
1459-1461 |
IN |
denotes |
in |
T9608 |
1462-1467 |
JJ |
denotes |
adult |
T9609 |
1468-1475 |
NNS |
denotes |
animals |
T9610 |
1476-1477 |
-LRB- |
denotes |
( |
T9611 |
1477-1483 |
NN |
denotes |
Figure |
T9612 |
1484-1486 |
CD |
denotes |
2A |
T9613 |
1486-1487 |
-RRB- |
denotes |
) |
T9614 |
1487-1488 |
. |
denotes |
. |
T9615 |
1488-1568 |
sentence |
denotes |
Although not specifically measured, mutant mice seem to have a normal lifespan. |
T9616 |
1489-1497 |
IN |
denotes |
Although |
T9617 |
1515-1523 |
VBN |
denotes |
measured |
T9618 |
1498-1501 |
RB |
denotes |
not |
T9619 |
1502-1514 |
RB |
denotes |
specifically |
T9620 |
1537-1541 |
VBP |
denotes |
seem |
T9621 |
1523-1525 |
, |
denotes |
, |
T9622 |
1525-1531 |
NN |
denotes |
mutant |
T9623 |
1532-1536 |
NNS |
denotes |
mice |
T9624 |
1542-1544 |
TO |
denotes |
to |
T9625 |
1545-1549 |
VB |
denotes |
have |
T9626 |
1550-1551 |
DT |
denotes |
a |
T9627 |
1559-1567 |
NN |
denotes |
lifespan |
T9628 |
1552-1558 |
JJ |
denotes |
normal |
T9629 |
1567-1568 |
. |
denotes |
. |
T9630 |
1568-1652 |
sentence |
denotes |
The one animal that was followed lived to 18 mo, typical for animals in our colony. |
T9631 |
1569-1572 |
DT |
denotes |
The |
T9632 |
1577-1583 |
NN |
denotes |
animal |
T9633 |
1573-1576 |
CD |
denotes |
one |
T9634 |
1602-1607 |
VBN |
denotes |
lived |
T9635 |
1584-1588 |
WDT |
denotes |
that |
T9636 |
1593-1601 |
VBN |
denotes |
followed |
T9637 |
1589-1592 |
VBD |
denotes |
was |
T9638 |
1608-1610 |
IN |
denotes |
to |
T9639 |
1611-1613 |
CD |
denotes |
18 |
T9640 |
1614-1616 |
NNS |
denotes |
mo |
T9641 |
1616-1618 |
, |
denotes |
, |
T9642 |
1618-1625 |
JJ |
denotes |
typical |
T9643 |
1626-1629 |
IN |
denotes |
for |
T9644 |
1630-1637 |
NNS |
denotes |
animals |
T9645 |
1638-1640 |
IN |
denotes |
in |
T9646 |
1641-1644 |
PRP$ |
denotes |
our |
T9647 |
1645-1651 |
NN |
denotes |
colony |
T9648 |
1651-1652 |
. |
denotes |
. |
R1249 |
T9316 |
T9304 |
nsubj |
mice,produce |
R1250 |
T9317 |
T9318 |
advmod |
very,dilute |
R1251 |
T9318 |
T9319 |
amod |
dilute,urine |
R1253 |
T9319 |
T9304 |
dobj |
urine,produce |
R1254 |
T9320 |
T9321 |
punct |
(,Figure |
R1255 |
T9321 |
T9304 |
parataxis |
Figure,produce |
R1257 |
T9322 |
T9321 |
nummod |
1D,Figure |
R1258 |
T9323 |
T9321 |
punct |
),Figure |
R1260 |
T9324 |
T9304 |
punct |
.,produce |
R1261 |
T9326 |
T9327 |
amod |
Basal,concentration |
R1264 |
T9327 |
T9329 |
nsubj |
concentration,is |
R1265 |
T9403 |
T9402 |
oprd |
desmopressin,called |
R1266 |
T9328 |
T9327 |
compound |
urine,concentration |
R1267 |
T9330 |
T9327 |
prep |
in,concentration |
R1268 |
T9331 |
T9332 |
compound |
mutant,mice |
R1269 |
T9332 |
T9330 |
pobj |
mice,in |
R1270 |
T9333 |
T9334 |
advmod |
about,161 |
R1271 |
T9404 |
T9383 |
punct |
),analog |
R1272 |
T9334 |
T9335 |
nummod |
161,mOsm |
R1273 |
T9335 |
T9329 |
attr |
mOsm,is |
R1274 |
T9405 |
T9386 |
punct |
", ",is |
R1275 |
T9336 |
T9335 |
punct |
", ",mOsm |
R1276 |
T9337 |
T9335 |
prep |
compared,mOsm |
R1277 |
T9338 |
T9337 |
prep |
to,compared |
R1278 |
T9406 |
T9407 |
det |
a,agonist |
R1279 |
T9339 |
T9340 |
quantmod |
about,"1,293" |
R1280 |
T9340 |
T9341 |
nummod |
"1,293",mOsm |
R1281 |
T9341 |
T9338 |
pobj |
mOsm,to |
R1282 |
T9407 |
T9386 |
attr |
agonist,is |
R1283 |
T9342 |
T9341 |
prep |
in,mOsm |
R1284 |
T9343 |
T9344 |
amod |
wild,type |
R1285 |
T9344 |
T9346 |
compound |
type,mice |
R1286 |
T9408 |
T9407 |
amod |
potent,agonist |
R1287 |
T9345 |
T9344 |
punct |
-,type |
R1288 |
T9346 |
T9342 |
pobj |
mice,in |
R1289 |
T9409 |
T9407 |
prep |
of,agonist |
R1290 |
T9347 |
T9348 |
punct |
(,0.001 |
R1291 |
T9348 |
T9329 |
parataxis |
0.001,is |
R1292 |
T9349 |
T9348 |
nsubj |
p,0.001 |
R1293 |
T9410 |
T9409 |
pobj |
AVPR2,of |
R1294 |
T9350 |
T9348 |
punct |
<,0.001 |
R1295 |
T9351 |
T9348 |
punct |
),0.001 |
R1296 |
T9352 |
T9329 |
punct |
.,is |
R1297 |
T9411 |
T9386 |
punct |
.,is |
R1298 |
T9354 |
T9355 |
advmod |
Normally,is |
R1299 |
T9413 |
T9414 |
advmod |
When,administered |
R1300 |
T9356 |
T9355 |
punct |
", ",is |
R1301 |
T9357 |
T9358 |
compound |
urine,concentration |
R1302 |
T9358 |
T9355 |
nsubj |
concentration,is |
R1303 |
T9359 |
T9355 |
prep |
under,is |
R1304 |
T9360 |
T9361 |
det |
the,control |
R1305 |
T9361 |
T9359 |
pobj |
control,under |
R1306 |
T9414 |
T9415 |
advcl |
administered,leads |
R1307 |
T9362 |
T9361 |
prep |
of,control |
R1308 |
T9363 |
T9364 |
det |
the,hypothalamus |
R1309 |
T9364 |
T9362 |
pobj |
hypothalamus,of |
R1310 |
T9365 |
T9364 |
punct |
", ",hypothalamus |
R1311 |
T9416 |
T9414 |
prep |
to,administered |
R1312 |
T9366 |
T9367 |
dep |
which,secretes |
R1313 |
T9367 |
T9364 |
relcl |
secretes,hypothalamus |
R1314 |
T9368 |
T9367 |
punct |
", ",secretes |
R1315 |
T9369 |
T9367 |
prep |
in,secretes |
R1316 |
T9417 |
T9418 |
amod |
wild,type |
R1317 |
T9370 |
T9369 |
pobj |
response,in |
R1318 |
T9371 |
T9370 |
prep |
to,response |
R1319 |
T9372 |
T9371 |
pobj |
hypovolemia,to |
R1320 |
T9373 |
T9372 |
cc |
or,hypovolemia |
R1321 |
T9374 |
T9372 |
conj |
hypernatremia,hypovolemia |
R1322 |
T9375 |
T9376 |
punct |
[,21 |
R1323 |
T9418 |
T9420 |
compound |
type,mice |
R1324 |
T9376 |
T9370 |
parataxis |
21,response |
R1325 |
T9377 |
T9376 |
punct |
],21 |
R1326 |
T9378 |
T9367 |
punct |
", ",secretes |
R1327 |
T9379 |
T9367 |
dobj |
AVP,secretes |
R1328 |
T9419 |
T9418 |
punct |
-,type |
R1329 |
T9380 |
T9355 |
punct |
.,is |
R1330 |
T9382 |
T9383 |
det |
The,analog |
R1331 |
T9420 |
T9416 |
pobj |
mice,to |
R1332 |
T9383 |
T9386 |
nsubj |
analog,is |
R1333 |
T9384 |
T9383 |
amod |
synthetic,analog |
R1334 |
T9421 |
T9415 |
punct |
", ",leads |
R1335 |
T9385 |
T9383 |
compound |
AVP,analog |
R1336 |
T9387 |
T9383 |
punct |
", ",analog |
R1337 |
T9422 |
T9415 |
nsubj |
dDAVP,leads |
R1338 |
T9388 |
T9389 |
nummod |
1,deamino |
R1339 |
T9389 |
T9391 |
nmod |
deamino,arginine |
R1340 |
T9390 |
T9389 |
punct |
-,deamino |
R1341 |
T9423 |
T9415 |
prep |
to,leads |
R1342 |
T9424 |
T9425 |
det |
a,increase |
R1343 |
T9391 |
T9397 |
compound |
arginine,vasopressin |
R1344 |
T9425 |
T9423 |
pobj |
increase,to |
R1345 |
T9392 |
T9391 |
punct |
-,arginine |
R1346 |
T9393 |
T9391 |
nummod |
8,arginine |
R1347 |
T9426 |
T9425 |
amod |
dramatic,increase |
R1348 |
T9394 |
T9391 |
punct |
-,arginine |
R1349 |
T9395 |
T9391 |
compound |
D,arginine |
R1350 |
T9396 |
T9391 |
punct |
-,arginine |
R1351 |
T9427 |
T9425 |
prep |
in,increase |
R1352 |
T9397 |
T9383 |
appos |
vasopressin,analog |
R1353 |
T9398 |
T9397 |
punct |
(,vasopressin |
R1354 |
T9399 |
T9397 |
appos |
dDAVP,vasopressin |
R1355 |
T9428 |
T9429 |
compound |
urine,concentration |
R1356 |
T9400 |
T9397 |
punct |
;,vasopressin |
R1357 |
T9401 |
T9402 |
advmod |
also,called |
R1358 |
T9402 |
T9397 |
acl |
called,vasopressin |
R1359 |
T9429 |
T9427 |
pobj |
concentration,in |
R1360 |
T9430 |
T9425 |
punct |
", ",increase |
R1361 |
T9431 |
T9425 |
prep |
from,increase |
R1362 |
T9432 |
T9431 |
pobj |
"1,293",from |
R1363 |
T9509 |
T9510 |
dep |
which,be |
R1364 |
T9510 |
T9505 |
relcl |
be,channel |
R1365 |
T9433 |
T9431 |
prep |
to,from |
R1366 |
T9511 |
T9510 |
aux |
must,be |
R1367 |
T9512 |
T9510 |
acomp |
sufficient,be |
R1368 |
T9513 |
T9514 |
aux |
to,allow |
R1369 |
T9434 |
T9433 |
pobj |
"5,885",to |
R1370 |
T9514 |
T9512 |
xcomp |
allow,sufficient |
R1371 |
T9515 |
T9514 |
dobj |
survival,allow |
R1372 |
T9516 |
T9515 |
prep |
of,survival |
R1373 |
T9517 |
T9518 |
det |
the,individual |
R1374 |
T9518 |
T9516 |
pobj |
individual,of |
R1375 |
T9519 |
T9497 |
punct |
", ",indicates |
R1376 |
T9435 |
T9431 |
pobj |
mOsm,from |
R1377 |
T9520 |
T9497 |
prep |
in,indicates |
R1378 |
T9521 |
T9520 |
pobj |
contrast,in |
R1379 |
T9522 |
T9521 |
prep |
to,contrast |
R1380 |
T9436 |
T9437 |
punct |
(,Figure |
R1381 |
T9523 |
T9524 |
det |
the,mouse |
R1382 |
T9524 |
T9522 |
pobj |
mouse,to |
R1383 |
T9437 |
T9415 |
parataxis |
Figure,leads |
R1384 |
T9525 |
T9524 |
nmod |
T126M,mouse |
R1385 |
T9526 |
T9524 |
amod |
knock,mouse |
R1386 |
T9527 |
T9526 |
punct |
-,knock |
R1387 |
T9528 |
T9526 |
prt |
in,knock |
R1388 |
T9438 |
T9437 |
advmod |
4.6-fold,Figure |
R1389 |
T9529 |
T9530 |
punct |
[,18 |
R1390 |
T9530 |
T9497 |
parataxis |
18,indicates |
R1391 |
T9531 |
T9530 |
punct |
],18 |
R1392 |
T9439 |
T9437 |
punct |
;,Figure |
R1393 |
T9532 |
T9497 |
punct |
.,indicates |
R1394 |
T9534 |
T9535 |
amod |
Multiple,matings |
R1395 |
T9440 |
T9437 |
nummod |
1D,Figure |
R1396 |
T9535 |
T9537 |
nsubj |
matings,yielded |
R1397 |
T9536 |
T9535 |
amod |
heterozygous,matings |
R1398 |
T9441 |
T9437 |
punct |
),Figure |
R1399 |
T9538 |
T9539 |
nummod |
101,animals |
R1400 |
T9539 |
T9537 |
dobj |
animals,yielded |
R1401 |
T9442 |
T9415 |
punct |
.,leads |
R1402 |
T9540 |
T9539 |
punct |
", ",animals |
R1403 |
T9541 |
T9542 |
dep |
which,appeared |
R1404 |
T9542 |
T9539 |
relcl |
appeared,animals |
R1405 |
T9543 |
T9542 |
prep |
at,appeared |
R1406 |
T9444 |
T9445 |
prep |
With,concentrate |
R1407 |
T9544 |
T9545 |
det |
a,ratio |
R1408 |
T9545 |
T9543 |
pobj |
ratio,at |
R1409 |
T9546 |
T9545 |
prep |
of,ratio |
R1410 |
T9547 |
T9546 |
pobj |
26,of |
R1411 |
T9446 |
T9447 |
amod |
similar,treatment |
R1412 |
T9548 |
T9549 |
punct |
:,49 |
R1413 |
T9549 |
T9547 |
prep |
49,26 |
R1414 |
T9550 |
T9551 |
punct |
:,26 |
R1415 |
T9447 |
T9444 |
pobj |
treatment,With |
R1416 |
T9551 |
T9547 |
prep |
26,26 |
R1417 |
T9552 |
T9542 |
punct |
", ",appeared |
R1418 |
T9553 |
T9542 |
prep |
near,appeared |
R1419 |
T9448 |
T9445 |
punct |
", ",concentrate |
R1420 |
T9554 |
T9555 |
det |
the,frequencies |
R1421 |
T9555 |
T9553 |
pobj |
frequencies,near |
R1422 |
T9556 |
T9555 |
amod |
expected,frequencies |
R1423 |
T9557 |
T9558 |
amod |
Mendelian,type |
R1424 |
T9558 |
T9555 |
nmod |
type,frequencies |
R1425 |
T9559 |
T9558 |
amod |
wild,type |
R1426 |
T9449 |
T9450 |
compound |
mutant,mice |
R1427 |
T9560 |
T9558 |
punct |
", ",type |
R1428 |
T9561 |
T9558 |
conj |
heterozygote,type |
R1429 |
T9562 |
T9561 |
punct |
", ",heterozygote |
R1430 |
T9450 |
T9445 |
nsubj |
mice,concentrate |
R1431 |
T9563 |
T9561 |
cc |
and,heterozygote |
R1432 |
T9564 |
T9561 |
conj |
mutant,heterozygote |
R1433 |
T9565 |
T9542 |
punct |
", ",appeared |
R1434 |
T9451 |
T9452 |
poss |
their,urine |
R1435 |
T9566 |
T9542 |
advmod |
respectively,appeared |
R1436 |
T9567 |
T9537 |
punct |
", ",yielded |
R1437 |
T9452 |
T9445 |
dobj |
urine,concentrate |
R1438 |
T9568 |
T9537 |
advcl |
indicating,yielded |
R1439 |
T9569 |
T9570 |
mark |
that,is |
R1440 |
T9570 |
T9568 |
ccomp |
is,indicating |
R1441 |
T9571 |
T9570 |
expl |
there,is |
R1442 |
T9453 |
T9445 |
prep |
to,concentrate |
R1443 |
T9572 |
T9573 |
det |
no,viability |
R1444 |
T9573 |
T9570 |
attr |
viability,is |
R1445 |
T9454 |
T9455 |
det |
a,extent |
R1446 |
T9574 |
T9573 |
amod |
reduced,viability |
R1447 |
T9575 |
T9573 |
acl |
associated,viability |
R1448 |
T9576 |
T9575 |
prep |
with,associated |
R1449 |
T9455 |
T9453 |
pobj |
extent,to |
R1450 |
T9577 |
T9578 |
det |
this,mutation |
R1451 |
T9578 |
T9576 |
pobj |
mutation,with |
R1452 |
T9579 |
T9537 |
punct |
.,yielded |
R1453 |
T9456 |
T9455 |
amod |
lesser,extent |
R1454 |
T9581 |
T9582 |
amod |
Other,was |
R1455 |
T9457 |
T9456 |
cc |
but,lesser |
R1456 |
T9583 |
T9581 |
prep |
than,Other |
R1457 |
T9458 |
T9459 |
advmod |
still,significant |
R1458 |
T9459 |
T9456 |
conj |
significant,lesser |
R1459 |
T9584 |
T9585 |
det |
the,production |
R1460 |
T9585 |
T9583 |
pobj |
production,than |
R1461 |
T9586 |
T9585 |
amod |
increased,production |
R1462 |
T9460 |
T9445 |
punct |
", ",concentrate |
R1463 |
T9587 |
T9585 |
compound |
urine,production |
R1464 |
T9588 |
T9585 |
cc |
and,production |
R1465 |
T9589 |
T9590 |
compound |
water,intake |
R1466 |
T9461 |
T9445 |
prep |
from,concentrate |
R1467 |
T9590 |
T9585 |
conj |
intake,production |
R1468 |
T9591 |
T9582 |
punct |
", ",was |
R1469 |
T9592 |
T9582 |
expl |
there,was |
R1470 |
T9462 |
T9461 |
pobj |
161,from |
R1471 |
T9593 |
T9594 |
det |
no,phenotype |
R1472 |
T9594 |
T9582 |
attr |
phenotype,was |
R1473 |
T9463 |
T9461 |
prep |
to,from |
R1474 |
T9595 |
T9594 |
amod |
overt,phenotype |
R1475 |
T9596 |
T9594 |
prep |
in,phenotype |
R1476 |
T9597 |
T9598 |
compound |
mutant,mice |
R1477 |
T9598 |
T9596 |
pobj |
mice,in |
R1478 |
T9599 |
T9594 |
punct |
", ",phenotype |
R1479 |
T9600 |
T9594 |
prep |
save,phenotype |
R1480 |
T9464 |
T9463 |
pobj |
470,to |
R1481 |
T9601 |
T9602 |
amod |
distended,kidneys |
R1482 |
T9602 |
T9600 |
pobj |
kidneys,save |
R1483 |
T9603 |
T9602 |
punct |
", ",kidneys |
R1484 |
T9465 |
T9461 |
pobj |
mOsm,from |
R1485 |
T9604 |
T9605 |
dep |
which,appeared |
R1486 |
T9605 |
T9602 |
relcl |
appeared,kidneys |
R1487 |
T9606 |
T9605 |
advmod |
variably,appeared |
R1488 |
T9466 |
T9467 |
punct |
(,2.9-fold |
R1489 |
T9607 |
T9605 |
prep |
in,appeared |
R1490 |
T9608 |
T9609 |
amod |
adult,animals |
R1491 |
T9609 |
T9607 |
pobj |
animals,in |
R1492 |
T9467 |
T9461 |
parataxis |
2.9-fold,from |
R1493 |
T9610 |
T9611 |
punct |
(,Figure |
R1494 |
T9611 |
T9582 |
parataxis |
Figure,was |
R1495 |
T9612 |
T9611 |
nummod |
2A,Figure |
R1496 |
T9468 |
T9467 |
punct |
),2.9-fold |
R1497 |
T9613 |
T9611 |
punct |
),Figure |
R1498 |
T9614 |
T9582 |
punct |
.,was |
R1499 |
T9469 |
T9445 |
punct |
", ",concentrate |
R1500 |
T9470 |
T9445 |
advcl |
indicating,concentrate |
R1501 |
T9471 |
T9472 |
mark |
that,are |
R1502 |
T9616 |
T9617 |
mark |
Although,measured |
R1503 |
T9472 |
T9470 |
ccomp |
are,indicating |
R1504 |
T9617 |
T9620 |
advcl |
measured,seem |
R1505 |
T9618 |
T9617 |
neg |
not,measured |
R1506 |
T9619 |
T9617 |
advmod |
specifically,measured |
R1507 |
T9473 |
T9474 |
det |
these,animals |
R1508 |
T9621 |
T9620 |
punct |
", ",seem |
R1509 |
T9622 |
T9623 |
compound |
mutant,mice |
R1510 |
T9474 |
T9472 |
nsubj |
animals,are |
R1511 |
T9623 |
T9620 |
nsubj |
mice,seem |
R1512 |
T9624 |
T9625 |
aux |
to,have |
R1513 |
T9625 |
T9620 |
xcomp |
have,seem |
R1514 |
T9475 |
T9472 |
preconj |
not,are |
R1515 |
T9626 |
T9627 |
det |
a,lifespan |
R1516 |
T9627 |
T9625 |
dobj |
lifespan,have |
R1517 |
T9628 |
T9627 |
amod |
normal,lifespan |
R1518 |
T9476 |
T9475 |
advmod |
only,not |
R1519 |
T9629 |
T9620 |
punct |
.,seem |
R1520 |
T9477 |
T9472 |
conj |
unable,are |
R1521 |
T9631 |
T9632 |
det |
The,animal |
R1522 |
T9632 |
T9634 |
nsubj |
animal,lived |
R1523 |
T9633 |
T9632 |
nummod |
one,animal |
R1524 |
T9478 |
T9479 |
aux |
to,concentrate |
R1525 |
T9635 |
T9636 |
dep |
that,followed |
R1526 |
T9636 |
T9632 |
relcl |
followed,animal |
R1527 |
T9637 |
T9636 |
auxpass |
was,followed |
R1528 |
T9638 |
T9634 |
prep |
to,lived |
R1529 |
T9639 |
T9640 |
nummod |
18,mo |
R1530 |
T9479 |
T9477 |
xcomp |
concentrate,unable |
R1531 |
T9640 |
T9638 |
pobj |
mo,to |
R1532 |
T9641 |
T9634 |
punct |
", ",lived |
R1533 |
T9642 |
T9634 |
advcl |
typical,lived |
R1534 |
T9480 |
T9481 |
poss |
their,urine |
R1535 |
T9643 |
T9642 |
prep |
for,typical |
R1536 |
T9644 |
T9643 |
pobj |
animals,for |
R1537 |
T9645 |
T9644 |
prep |
in,animals |
R1538 |
T9481 |
T9479 |
dobj |
urine,concentrate |
R1539 |
T9646 |
T9647 |
poss |
our,colony |
R1540 |
T9647 |
T9645 |
pobj |
colony,in |
R1541 |
T9648 |
T9634 |
punct |
.,lived |
R1542 |
T9482 |
T9479 |
advmod |
properly,concentrate |
R1545 |
T9483 |
T9472 |
cc |
but,are |
R1548 |
T9484 |
T9472 |
conj |
are,are |
R1551 |
T9485 |
T9484 |
advmod |
also,are |
R1554 |
T9486 |
T9484 |
acomp |
defective,are |
R1558 |
T9487 |
T9484 |
prep |
in,are |
R1562 |
T9488 |
T9489 |
poss |
their,response |
R1566 |
T9489 |
T9487 |
pobj |
response,in |
R1569 |
T9490 |
T9489 |
prep |
to,response |
R1570 |
T9491 |
T9490 |
pobj |
dDAVP,to |
R1572 |
T9492 |
T9445 |
punct |
.,concentrate |
R1576 |
T9494 |
T9495 |
det |
The,response |
R1582 |
T9495 |
T9497 |
nsubj |
response,indicates |
R1585 |
T9496 |
T9495 |
amod |
smaller,response |
R1589 |
T9498 |
T9495 |
prep |
to,response |
R1594 |
T9499 |
T9498 |
pobj |
dDAVP,to |
R1598 |
T9500 |
T9501 |
det |
some,activity |
R1602 |
T9501 |
T9497 |
dobj |
activity,indicates |
R1605 |
T9502 |
T9501 |
amod |
residual,activity |
R1609 |
T9503 |
T9501 |
prep |
of,activity |
R1614 |
T9504 |
T9505 |
det |
the,channel |
R1617 |
T9505 |
T9503 |
pobj |
channel,of |
R1620 |
T9506 |
T9505 |
compound |
mutant,channel |
R1623 |
T9507 |
T9505 |
compound |
AQP2,channel |
R1627 |
T9508 |
T9505 |
punct |
", ",channel |