PMC:1189073 / 5859-6695
Annnotations
craft-ca-core-ex-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2427 | 45-49 | PR_EXT:000004182 | denotes | Aqp2 |
T2425 | 13-20 | SO_EXT:0000704 | denotes | genetic |
T2426 | 31-36 | NCBITaxon:10088 | denotes | mouse |
T2428 | 50-58 | SO_EXT:sequence_alteration_entity_or_process | denotes | mutation |
T2429 | 126-132 | NCBITaxon:39107 | denotes | murine |
T2430 | 152-163 | GO:0001822 | denotes | nephrogenic |
T2431 | 196-204 | SO_EXT:sequence_alteration_entity_or_process | denotes | mutation |
T2432 | 212-216 | PR_EXT:000004182 | denotes | Aqp2 |
T2433 | 217-221 | SO_EXT:0000704 | denotes | gene |
T2434 | 228-234 | SO_EXT:0001023 | denotes | allele |
T2435 | 238-242 | PR_EXT:000004182 | denotes | Aqp2 |
T2436 | 272-277 | NCBITaxon:10088 | denotes | mouse |
T2437 | 325-329 | UBERON:0000104 | denotes | life |
T2438 | 331-340 | CHEBI_EXT:polyatomic_entity_or_group | denotes | Molecular |
T2439 | 365-371 | SO_EXT:sequence_altered_entity_or_alteration_process | denotes | mutant |
T2440 | 372-376 | PR_EXT:000004182 | denotes | AQP2 |
T2441 | 396-407 | GO_UBERON_EXT:cellular_component_or_cell_part | denotes | subcellular |
T2442 | 399-407 | CL_GO_EXT:cell | denotes | cellular |
T2443 | 408-420 | GO_PATO_EXT:biological_localization_process_or_quality | denotes | localization |
T2444 | 424-445 | UBERON:0001232 | denotes | renal collecting-duct |
T2445 | 424-451 | CL:1001225 | denotes | renal collecting-duct cells |
T2446 | 446-451 | CL_GO_EXT:cell | denotes | cells |
T2447 | 474-487 | GO_EXT:biological_translocation_entity_or_process | denotes | translocation |
T2448 | 499-511 | CHEBI:4450 | denotes | desmopressin |
T2449 | 516-523 | CHEBI_GO_EXT:agonist | denotes | agonist |
T2450 | 527-530 | CHEBI_PR_EXT:arginine_vasopressin | denotes | AVP |
T2451 | 571-577 | NCBITaxon:9608 | denotes | canine |
T2452 | 578-584 | UBERON:0002113 | denotes | kidney |
T2453 | 578-584 | _FRAGMENT | denotes | kidney |
T2454 | 592-596 | CL:1000497 | denotes | cell |
T2455 | 592-596 | CL_GO_EXT:cell | denotes | cell |
T2456 | 618-639 | GO:0005783 | denotes | endoplasmic reticulum |
T2457 | 656-662 | SO_EXT:sequence_altered_entity_or_alteration_process | denotes | mutant |
T2458 | 663-670 | CHEBI_PR_EXT:protein | denotes | protein |
T2459 | 699-712 | GO_EXT:biological_translocation_entity_or_process | denotes | translocation |
T2460 | 749-758 | GO:0030849 | denotes | autosomal |
T2461 | 802-806 | PR_EXT:000004182 | denotes | AQP2 |
T2462 | 807-814 | GO_EXT:biological_routing_or_transport | denotes | routing |
T2463 | 829-835 | NCBITaxon:40674 | denotes | mammal |
R253 | T2454 | T2453 | _lexicallyChainedTo | cell,kidney |
craft-ca-core-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2277 | 13-20 | SO:0000704 | denotes | genetic |
T2278 | 31-36 | NCBITaxon:10088 | denotes | mouse |
T2279 | 45-49 | PR:000004182 | denotes | Aqp2 |
T2280 | 126-132 | NCBITaxon:39107 | denotes | murine |
T2281 | 152-163 | GO:0001822 | denotes | nephrogenic |
T2282 | 212-216 | PR:000004182 | denotes | Aqp2 |
T2283 | 217-221 | SO:0000704 | denotes | gene |
T2284 | 228-234 | SO:0001023 | denotes | allele |
T2285 | 238-242 | PR:000004182 | denotes | Aqp2 |
T2286 | 272-277 | NCBITaxon:10088 | denotes | mouse |
T2287 | 325-329 | UBERON:0000104 | denotes | life |
T2288 | 372-376 | PR:000004182 | denotes | AQP2 |
T2289 | 424-445 | UBERON:0001232 | denotes | renal collecting-duct |
T2290 | 424-451 | CL:1001225 | denotes | renal collecting-duct cells |
T2291 | 499-511 | CHEBI:4450 | denotes | desmopressin |
T2292 | 571-577 | NCBITaxon:9608 | denotes | canine |
T2293 | 578-584 | UBERON:0002113 | denotes | kidney |
T2294 | 578-584 | _FRAGMENT | denotes | kidney |
T2295 | 592-596 | CL:1000497 | denotes | cell |
T2296 | 618-639 | GO:0005783 | denotes | endoplasmic reticulum |
T2297 | 749-758 | GO:0030849 | denotes | autosomal |
T2298 | 802-806 | PR:000004182 | denotes | AQP2 |
T2299 | 829-835 | NCBITaxon:40674 | denotes | mammal |
R246 | T2295 | T2294 | _lexicallyChainedTo | cell,kidney |
craft-sa-dev
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3010 | 0-2 | IN | denotes | In |
T3011 | 63-73 | VBN | denotes | identified |
T3012 | 3-4 | DT | denotes | a |
T3013 | 21-27 | NN | denotes | screen |
T3014 | 5-12 | RB | denotes | forward |
T3015 | 13-20 | JJ | denotes | genetic |
T3016 | 27-29 | , | denotes | , |
T3017 | 29-30 | DT | denotes | a |
T3018 | 31-36 | NN | denotes | mouse |
T3019 | 37-41 | IN | denotes | with |
T3020 | 42-44 | DT | denotes | an |
T3021 | 50-58 | NN | denotes | mutation |
T3022 | 45-49 | NN | denotes | Aqp2 |
T3023 | 59-62 | VBD | denotes | was |
T3024 | 73-74 | . | denotes | . |
T3025 | 74-167 | sentence | denotes | The purpose of this study was to characterize this murine model of recessive nephrogenic DI. |
T3026 | 75-78 | DT | denotes | The |
T3027 | 79-86 | NN | denotes | purpose |
T3028 | 101-104 | VBD | denotes | was |
T3029 | 87-89 | IN | denotes | of |
T3030 | 90-94 | DT | denotes | this |
T3031 | 95-100 | NN | denotes | study |
T3032 | 105-107 | TO | denotes | to |
T3033 | 108-120 | VB | denotes | characterize |
T3034 | 121-125 | DT | denotes | this |
T3035 | 133-138 | NN | denotes | model |
T3036 | 126-132 | JJ | denotes | murine |
T3037 | 139-141 | IN | denotes | of |
T3038 | 142-151 | JJ | denotes | recessive |
T3039 | 164-166 | NN | denotes | DI |
T3040 | 152-163 | JJ | denotes | nephrogenic |
T3041 | 166-167 | . | denotes | . |
T3042 | 167-222 | sentence | denotes | We now report a novel F204V mutation in the Aqp2 gene. |
T3043 | 168-170 | PRP | denotes | We |
T3044 | 175-181 | VBP | denotes | report |
T3045 | 171-174 | RB | denotes | now |
T3046 | 182-183 | DT | denotes | a |
T3047 | 196-204 | NN | denotes | mutation |
T3048 | 184-189 | JJ | denotes | novel |
T3049 | 190-195 | NN | denotes | F204V |
T3050 | 205-207 | IN | denotes | in |
T3051 | 208-211 | DT | denotes | the |
T3052 | 217-221 | NN | denotes | gene |
T3053 | 212-216 | NN | denotes | Aqp2 |
T3054 | 221-222 | . | denotes | . |
T3055 | 222-330 | sentence | denotes | This allele of Aqp2 was found to cause the first mouse model of NDI to survive past the first week of life. |
T3056 | 223-227 | DT | denotes | This |
T3057 | 228-234 | NN | denotes | allele |
T3058 | 247-252 | VBN | denotes | found |
T3059 | 235-237 | IN | denotes | of |
T3060 | 238-242 | NN | denotes | Aqp2 |
T3061 | 243-246 | VBD | denotes | was |
T3062 | 253-255 | TO | denotes | to |
T3063 | 256-261 | VB | denotes | cause |
T3064 | 262-265 | DT | denotes | the |
T3065 | 278-283 | NN | denotes | model |
T3066 | 266-271 | JJ | denotes | first |
T3067 | 272-277 | NN | denotes | mouse |
T3068 | 294-301 | VB | denotes | survive |
T3069 | 284-286 | IN | denotes | of |
T3070 | 287-290 | NN | denotes | NDI |
T3071 | 291-293 | TO | denotes | to |
T3072 | 302-306 | IN | denotes | past |
T3073 | 307-310 | DT | denotes | the |
T3074 | 317-321 | NN | denotes | week |
T3075 | 311-316 | JJ | denotes | first |
T3076 | 322-324 | IN | denotes | of |
T3077 | 325-329 | NN | denotes | life |
T3078 | 329-330 | . | denotes | . |
T3079 | 330-531 | sentence | denotes | Molecular analyses concluded that mutant AQP2 adopts a different subcellular localization in renal collecting-duct cells, and was resistant to translocation induced by desmopressin, an agonist of AVP. |
T3080 | 331-340 | JJ | denotes | Molecular |
T3081 | 341-349 | NNS | denotes | analyses |
T3082 | 350-359 | VBD | denotes | concluded |
T3083 | 360-364 | IN | denotes | that |
T3084 | 377-383 | VBZ | denotes | adopts |
T3085 | 365-371 | NN | denotes | mutant |
T3086 | 372-376 | NN | denotes | AQP2 |
T3087 | 384-385 | DT | denotes | a |
T3088 | 408-420 | NN | denotes | localization |
T3089 | 386-395 | JJ | denotes | different |
T3090 | 396-407 | JJ | denotes | subcellular |
T3091 | 421-423 | IN | denotes | in |
T3092 | 424-429 | JJ | denotes | renal |
T3093 | 446-451 | NNS | denotes | cells |
T3094 | 430-440 | VBG | denotes | collecting |
T3095 | 441-445 | NN | denotes | duct |
T3096 | 440-441 | HYPH | denotes | - |
T3097 | 451-453 | , | denotes | , |
T3098 | 453-456 | CC | denotes | and |
T3099 | 457-460 | VBD | denotes | was |
T3100 | 461-470 | JJ | denotes | resistant |
T3101 | 471-473 | IN | denotes | to |
T3102 | 474-487 | NN | denotes | translocation |
T3103 | 488-495 | VBN | denotes | induced |
T3104 | 496-498 | IN | denotes | by |
T3105 | 499-511 | NN | denotes | desmopressin |
T3106 | 511-513 | , | denotes | , |
T3107 | 513-515 | DT | denotes | an |
T3108 | 516-523 | NN | denotes | agonist |
T3109 | 524-526 | IN | denotes | of |
T3110 | 527-530 | NN | denotes | AVP |
T3111 | 530-531 | . | denotes | . |
T3112 | 531-713 | sentence | denotes | In vitro studies using the Madin-Darby canine kidney (MDCK) cell line demonstrated an endoplasmic reticulum pattern for the mutant protein, and apparent resistance to translocation. |
T3113 | 532-534 | FW | denotes | In |
T3114 | 535-540 | FW | denotes | vitro |
T3115 | 541-548 | NNS | denotes | studies |
T3116 | 602-614 | VBD | denotes | demonstrated |
T3117 | 549-554 | VBG | denotes | using |
T3118 | 555-558 | DT | denotes | the |
T3119 | 597-601 | NN | denotes | line |
T3120 | 559-564 | NN | denotes | Madin |
T3121 | 565-570 | NN | denotes | Darby |
T3122 | 564-565 | HYPH | denotes | - |
T3123 | 578-584 | NN | denotes | kidney |
T3124 | 571-577 | JJ | denotes | canine |
T3125 | 585-586 | -LRB- | denotes | ( |
T3126 | 586-590 | NN | denotes | MDCK |
T3127 | 590-591 | -RRB- | denotes | ) |
T3128 | 592-596 | NN | denotes | cell |
T3129 | 615-617 | DT | denotes | an |
T3130 | 640-647 | NN | denotes | pattern |
T3131 | 618-629 | JJ | denotes | endoplasmic |
T3132 | 630-639 | NN | denotes | reticulum |
T3133 | 648-651 | IN | denotes | for |
T3134 | 652-655 | DT | denotes | the |
T3135 | 663-670 | NN | denotes | protein |
T3136 | 656-662 | NN | denotes | mutant |
T3137 | 670-672 | , | denotes | , |
T3138 | 672-675 | CC | denotes | and |
T3139 | 676-684 | JJ | denotes | apparent |
T3140 | 685-695 | NN | denotes | resistance |
T3141 | 696-698 | IN | denotes | to |
T3142 | 699-712 | NN | denotes | translocation |
T3143 | 712-713 | . | denotes | . |
T3144 | 713-836 | sentence | denotes | These data conclusively prove that autosomal recessive NDI is a consequence of improper AQP2 routing in the intact mammal. |
T3145 | 714-719 | DT | denotes | These |
T3146 | 720-724 | NNS | denotes | data |
T3147 | 738-743 | VBP | denotes | prove |
T3148 | 725-737 | RB | denotes | conclusively |
T3149 | 744-748 | IN | denotes | that |
T3150 | 773-775 | VBZ | denotes | is |
T3151 | 749-758 | JJ | denotes | autosomal |
T3152 | 769-772 | NN | denotes | NDI |
T3153 | 759-768 | JJ | denotes | recessive |
T3154 | 776-777 | DT | denotes | a |
T3155 | 778-789 | NN | denotes | consequence |
T3156 | 790-792 | IN | denotes | of |
T3157 | 793-801 | JJ | denotes | improper |
T3158 | 807-814 | NN | denotes | routing |
T3159 | 802-806 | NN | denotes | AQP2 |
T3160 | 815-817 | IN | denotes | in |
T3161 | 818-821 | DT | denotes | the |
T3162 | 829-835 | NN | denotes | mammal |
T3163 | 822-828 | JJ | denotes | intact |
T3164 | 835-836 | . | denotes | . |
R745 | T3096 | T3095 | punct | -,duct |
R747 | T3097 | T3084 | punct | ", ",adopts |
R750 | T3098 | T3084 | cc | and,adopts |
R753 | T3099 | T3084 | conj | was,adopts |
R756 | T3100 | T3099 | acomp | resistant,was |
R762 | T3101 | T3100 | prep | to,resistant |
R766 | T3102 | T3101 | pobj | translocation,to |
R770 | T3103 | T3102 | acl | induced,translocation |
R772 | T3010 | T3011 | prep | In,identified |
R773 | T3104 | T3103 | agent | by,induced |
R774 | T3012 | T3013 | det | a,screen |
R775 | T3105 | T3104 | pobj | desmopressin,by |
R776 | T3013 | T3010 | pobj | screen,In |
R777 | T3014 | T3015 | advmod | forward,genetic |
R778 | T3015 | T3013 | amod | genetic,screen |
R779 | T3016 | T3011 | punct | ", ",identified |
R780 | T3106 | T3105 | punct | ", ",desmopressin |
R781 | T3017 | T3018 | det | a,mouse |
R782 | T3018 | T3011 | nsubjpass | mouse,identified |
R783 | T3107 | T3108 | det | an,agonist |
R784 | T3019 | T3018 | prep | with,mouse |
R785 | T3020 | T3021 | det | an,mutation |
R786 | T3021 | T3019 | pobj | mutation,with |
R787 | T3108 | T3105 | appos | agonist,desmopressin |
R788 | T3109 | T3108 | prep | of,agonist |
R789 | T3022 | T3021 | compound | Aqp2,mutation |
R790 | T3023 | T3011 | auxpass | was,identified |
R791 | T3024 | T3011 | punct | .,identified |
R792 | T3026 | T3027 | det | The,purpose |
R793 | T3110 | T3109 | pobj | AVP,of |
R794 | T3027 | T3028 | nsubj | purpose,was |
R795 | T3029 | T3027 | prep | of,purpose |
R796 | T3030 | T3031 | det | this,study |
R797 | T3111 | T3082 | punct | .,concluded |
R798 | T3031 | T3029 | pobj | study,of |
R799 | T3032 | T3033 | aux | to,characterize |
R800 | T3033 | T3028 | xcomp | characterize,was |
R801 | T3113 | T3114 | advmod | In,vitro |
R802 | T3034 | T3035 | det | this,model |
R803 | T3035 | T3033 | dobj | model,characterize |
R804 | T3036 | T3035 | amod | murine,model |
R805 | T3037 | T3035 | prep | of,model |
R806 | T3114 | T3115 | amod | vitro,studies |
R807 | T3038 | T3039 | amod | recessive,DI |
R808 | T3039 | T3037 | pobj | DI,of |
R809 | T3115 | T3116 | nsubj | studies,demonstrated |
R810 | T3040 | T3039 | amod | nephrogenic,DI |
R811 | T3041 | T3028 | punct | .,was |
R812 | T3043 | T3044 | nsubj | We,report |
R813 | T3045 | T3044 | advmod | now,report |
R814 | T3117 | T3115 | acl | using,studies |
R815 | T3046 | T3047 | det | a,mutation |
R816 | T3047 | T3044 | dobj | mutation,report |
R817 | T3048 | T3047 | amod | novel,mutation |
R818 | T3049 | T3047 | compound | F204V,mutation |
R819 | T3118 | T3119 | det | the,line |
R820 | T3050 | T3047 | prep | in,mutation |
R821 | T3051 | T3052 | det | the,gene |
R822 | T3052 | T3050 | pobj | gene,in |
R823 | T3119 | T3117 | dobj | line,using |
R824 | T3053 | T3052 | compound | Aqp2,gene |
R825 | T3054 | T3044 | punct | .,report |
R826 | T3120 | T3121 | nmod | Madin,Darby |
R827 | T3056 | T3057 | det | This,allele |
R828 | T3057 | T3058 | nsubjpass | allele,found |
R829 | T3121 | T3123 | nmod | Darby,kidney |
R830 | T3059 | T3057 | prep | of,allele |
R831 | T3060 | T3059 | pobj | Aqp2,of |
R832 | T3122 | T3121 | punct | -,Darby |
R833 | T3061 | T3058 | auxpass | was,found |
R834 | T3062 | T3063 | aux | to,cause |
R835 | T3063 | T3058 | xcomp | cause,found |
R836 | T3123 | T3119 | nmod | kidney,line |
R837 | T3064 | T3065 | det | the,model |
R838 | T3065 | T3068 | nsubj | model,survive |
R839 | T3124 | T3123 | amod | canine,kidney |
R840 | T3066 | T3065 | amod | first,model |
R841 | T3067 | T3065 | compound | mouse,model |
R842 | T3125 | T3123 | punct | (,kidney |
R843 | T3068 | T3063 | ccomp | survive,cause |
R844 | T3069 | T3065 | prep | of,model |
R845 | T3070 | T3069 | pobj | NDI,of |
R846 | T3126 | T3123 | appos | MDCK,kidney |
R847 | T3071 | T3068 | aux | to,survive |
R848 | T3072 | T3068 | prep | past,survive |
R849 | T3073 | T3074 | det | the,week |
R850 | T3127 | T3119 | punct | ),line |
R851 | T3074 | T3072 | pobj | week,past |
R852 | T3075 | T3074 | amod | first,week |
R853 | T3076 | T3074 | prep | of,week |
R854 | T3128 | T3119 | compound | cell,line |
R855 | T3129 | T3130 | det | an,pattern |
R856 | T3130 | T3116 | dobj | pattern,demonstrated |
R857 | T3077 | T3076 | pobj | life,of |
R858 | T3078 | T3058 | punct | .,found |
R859 | T3131 | T3130 | amod | endoplasmic,pattern |
R860 | T3080 | T3081 | amod | Molecular,analyses |
R861 | T3132 | T3130 | compound | reticulum,pattern |
R862 | T3081 | T3082 | nsubj | analyses,concluded |
R863 | T3083 | T3084 | mark | that,adopts |
R864 | T3084 | T3082 | ccomp | adopts,concluded |
R865 | T3085 | T3086 | compound | mutant,AQP2 |
R866 | T3086 | T3084 | nsubj | AQP2,adopts |
R867 | T3133 | T3130 | prep | for,pattern |
R868 | T3087 | T3088 | det | a,localization |
R869 | T3088 | T3084 | dobj | localization,adopts |
R870 | T3089 | T3088 | amod | different,localization |
R871 | T3134 | T3135 | det | the,protein |
R872 | T3090 | T3088 | amod | subcellular,localization |
R873 | T3091 | T3084 | prep | in,adopts |
R874 | T3092 | T3093 | amod | renal,cells |
R875 | T3135 | T3133 | pobj | protein,for |
R876 | T3093 | T3091 | pobj | cells,in |
R877 | T3094 | T3095 | amod | collecting,duct |
R878 | T3136 | T3135 | compound | mutant,protein |
R879 | T3095 | T3093 | compound | duct,cells |
R880 | T3137 | T3130 | punct | ", ",pattern |
R881 | T3138 | T3130 | cc | and,pattern |
R882 | T3139 | T3140 | amod | apparent,resistance |
R883 | T3140 | T3130 | conj | resistance,pattern |
R884 | T3141 | T3140 | prep | to,resistance |
R885 | T3142 | T3141 | pobj | translocation,to |
R886 | T3143 | T3116 | punct | .,demonstrated |
R887 | T3145 | T3146 | det | These,data |
R888 | T3146 | T3147 | nsubj | data,prove |
R889 | T3148 | T3147 | advmod | conclusively,prove |
R890 | T3149 | T3150 | mark | that,is |
R891 | T3150 | T3147 | ccomp | is,prove |
R892 | T3151 | T3152 | amod | autosomal,NDI |
R893 | T3152 | T3150 | nsubj | NDI,is |
R894 | T3153 | T3152 | amod | recessive,NDI |
R895 | T3154 | T3155 | det | a,consequence |
R896 | T3155 | T3150 | attr | consequence,is |
R897 | T3156 | T3155 | prep | of,consequence |
R898 | T3157 | T3158 | amod | improper,routing |
R899 | T3158 | T3156 | pobj | routing,of |
R900 | T3159 | T3158 | compound | AQP2,routing |
R901 | T3160 | T3158 | prep | in,routing |
R902 | T3161 | T3162 | det | the,mammal |
R903 | T3162 | T3160 | pobj | mammal,in |
R904 | T3163 | T3162 | amod | intact,mammal |
R905 | T3164 | T3147 | punct | .,prove |