PMC:1189073 / 5289-5858 JSONTXT

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    craft-ca-core-ex-dev

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    craft-ca-core-dev

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    craft-sa-dev

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    2_test

    {"project":"2_test","denotations":[{"id":"16121255-10737773-85587785","span":{"begin":64,"end":66},"obj":"10737773"},{"id":"16121255-9468475-85587785","span":{"begin":64,"end":66},"obj":"9468475"},{"id":"16121255-11104789-85587785","span":{"begin":64,"end":66},"obj":"11104789"},{"id":"16121255-11035042-85587785","span":{"begin":64,"end":66},"obj":"11035042"},{"id":"16121255-9916798-85587785","span":{"begin":64,"end":66},"obj":"9916798"},{"id":"16121255-11104789-85587786","span":{"begin":172,"end":174},"obj":"11104789"},{"id":"16121255-11035038-85587787","span":{"begin":175,"end":177},"obj":"11035038"},{"id":"T73785","span":{"begin":64,"end":66},"obj":"10737773"},{"id":"T69562","span":{"begin":64,"end":66},"obj":"9468475"},{"id":"T43226","span":{"begin":64,"end":66},"obj":"11104789"},{"id":"T51402","span":{"begin":64,"end":66},"obj":"11035042"},{"id":"T85688","span":{"begin":64,"end":66},"obj":"9916798"},{"id":"T21889","span":{"begin":172,"end":174},"obj":"11104789"},{"id":"T948","span":{"begin":175,"end":177},"obj":"11035038"}],"text":"Several mouse models of diabetes insipidus have been generated [13–17]. In an attempt to recapitulate human NDI, mice have been generated with mutations in Aqp2 and Avpr2 [15,18]. Yang and colleagues created a mouse with a T126M knock-in mutation in the Aqp2 gene. Unexpectedly, homozygous mutant mice died within 6 d after birth. Interestingly, AVPR2-deficient male pups also die within the first week after birth. Together these models suggest that the mouse may be a highly sensitive organism with regard to water homeostasis, and is unable to survive with polyuria."}