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PMC:1189073 / 3078-6695 JSONTXT

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craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2300 13-24 GO:0001822 denotes Nephrogenic
T2301 90-99 GO:0060073 denotes urination
T2302 149-157 CHEBI_EXT:diuretic_agent_or_process denotes diuretic
T2303 158-165 CHEBI_GO_EXT:hormone denotes hormone
T2304 166-174 CHEBI_SO_EXT:arginine denotes arginine
T2305 166-186 CHEBI_PR_EXT:arginine_vasopressin denotes arginine vasopressin
T2306 188-191 CHEBI_PR_EXT:arginine_vasopressin denotes AVP
T2307 229-230 GO:0000805 denotes X
T2308 258-266 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T2309 274-279 PR_EXT:000001683 denotes Avpr2
T2310 280-284 SO_EXT:0000704 denotes gene
T2311 293-302 GO:0030849 denotes autosomal
T2312 310-318 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T2313 326-330 PR_EXT:000004182 denotes Aqp2
T2314 331-335 SO_EXT:0000704 denotes gene
T2315 341-352 PR_EXT:000004182 denotes Aquaporin-2
T2316 354-358 PR_EXT:000004182 denotes AQP2
T2317 365-369 GO_EXT:0015267 denotes pore
T2318 378-385 CHEBI_PR_EXT:protein denotes protein
T2319 411-416 CHEBI:15377 denotes water
T2320 411-425 GO_EXT:0015250 denotes water channels
T2321 441-450 GO:0010467 denotes expressed
T2322 454-469 UBERON:0001232 denotes collecting-duct
T2323 454-485 CL:1001431 denotes collecting-duct principal cells
T2324 480-485 CL_GO_EXT:cell denotes cells
T2325 493-499 UBERON:0002113 denotes kidney
T2326 521-529 CHEBI_PR_EXT:protein denotes proteins
T2327 541-557 GO:0006833 denotes passage of water
T2328 541-548 _FRAGMENT denotes passage
T2329 558-565 _FRAGMENT denotes through
T2330 577-585 GO:0055085 denotes membrane
T2331 552-557 CHEBI:15377 denotes water
T2332 570-585 GO:0005886 denotes plasma membrane
T2333 587-589 GO:0005886 denotes PM
T2334 594-599 CL_GO_EXT:cell denotes cells
T2335 669-674 CHEBI:15377 denotes water
T2336 669-687 _FRAGMENT denotes water reabsorption
T2337 699-701 _FRAGMENT denotes in
T2338 706-712 GO:0070295 denotes kidney
T2339 693-698 UBERON:0001088 denotes urine
T2340 706-712 UBERON:0002113 denotes kidney
T2341 789-800 GO:0051262 denotes tetramerize
T2342 833-848 GO:0005886 denotes plasma membrane
T2343 874-882 CHEBI_PR_EXT:protein denotes proteins
T2344 910-918 GO_EXT:biological_routing_or_transport denotes targeted
T2345 931-941 _FRAGMENT denotes regions of
T2346 946-948 GO:0044459 denotes PM
T2347 963-967 PR_EXT:000004182 denotes AQP2
T2427 2826-2830 PR_EXT:000004182 denotes Aqp2
T2348 971-977 GO_EXT:biological_routing_or_transport denotes routed
T2349 985-1009 GO:0016324 denotes apical membrane of cells
T2350 1004-1009 CL_GO_EXT:cell denotes cells
T2351 1026-1041 UBERON:0001232 denotes collecting duct
T2352 1069-1073 PR_EXT:000004183 denotes AQP3
T2353 1102-1118 GO:1990794 denotes basolateral face
T2354 1153-1157 PR_EXT:000004182 denotes AQP2
T2355 1198-1213 GO:0005886 denotes plasma membrane
T2356 1243-1250 CHEBI_PR_EXT:protein denotes protein
T2357 1265-1271 GO:0016324 denotes apical
T2358 1272-1285 GO:0005622 denotes intracellular
T2359 1277-1285 CL_GO_EXT:cell denotes cellular
T2360 1286-1294 GO:0031982 denotes vesicles
T2361 1332-1337 CHEBI:15377 denotes water
T2362 1348-1352 PR_EXT:000004182 denotes AQP2
T2363 1353-1365 GO_EXT:biological_movement_or_translocation_process denotes translocates
T2364 1373-1388 GO:0016324 denotes apical membrane
T2365 1401-1406 CHEBI:15377 denotes water
T2366 1454-1457 CHEBI_PR_EXT:arginine_vasopressin denotes AVP
T2367 1458-1463 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T2368 1468-1476 GO_EXT:0004872 denotes receptor
T2369 1478-1483 PR_EXT:000001683 denotes AVPR2
T2370 1492-1511 _FRAGMENT denotes basolateral face of
T2371 1532-1537 GO:1990794 denotes cells
T2372 1516-1531 UBERON:0001232 denotes collecting duct
T2373 1516-1537 CL:1001225 denotes collecting duct cells
T2374 1560-1573 GO:0005622 denotes intracellular
T2375 1565-1573 CL_GO_EXT:cell denotes cellular
T2376 1574-1578 CHEBI:17489 denotes cAMP
T2377 1604-1619 GO_PATO_EXT:phosphorylation_process denotes phosphorylation
T2378 1623-1627 PR_EXT:000004182 denotes AQP2
T2379 1631-1637 CHEBI_SO_EXT:serine denotes serine
T2380 1645-1649 CHEBI:17489 denotes cAMP
T2381 1645-1674 GO_EXT:0004691 denotes cAMP-dependent protein kinase
T2382 1660-1667 CHEBI_PR_EXT:protein denotes protein
T2383 1709-1724 GO:0005886 denotes plasma membrane
T2384 1744-1748 PR_EXT:000004182 denotes AQP2
T2385 1819-1823 PR_EXT:000004182 denotes Aqp2
T2386 1824-1833 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T2387 1861-1867 NCBITaxon:9606 denotes humans
T2388 1886-1890 PR_EXT:000004182 denotes Aqp2
T2389 1891-1900 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T2390 1948-1957 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T2392 1992-1997 CHEBI:15377 denotes water
T2393 1992-2002 GO_EXT:0015250 denotes water pore
T2394 2008-2016 GO_EXT:reaction_or_response denotes responds
T2395 2046-2050 CHEBI:17489 denotes cAMP
T2396 2081-2090 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T2397 2127-2132 GO_EXT:biological_routing_or_transport denotes route
T2398 2142-2148 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2399 2157-2166 SO_EXT:wild_type_entity_or_quality denotes wild-type
T2400 2167-2174 CHEBI_PR_EXT:protein denotes protein
T2401 2182-2202 GO:0016323 denotes basolateral membrane
T2402 2219-2224 NCBITaxon:10088 denotes mouse
T2403 2313-2318 NCBITaxon:9606 denotes human
T2404 2324-2328 NCBITaxon:10088 denotes mice
T2405 2354-2363 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T2406 2367-2371 PR_EXT:000004182 denotes Aqp2
T2407 2376-2381 PR_EXT:000001683 denotes Avpr2
T2408 2421-2426 NCBITaxon:10088 denotes mouse
T2409 2449-2457 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T2410 2465-2469 PR_EXT:000004182 denotes Aqp2
T2411 2470-2474 SO_EXT:0000704 denotes gene
T2412 2501-2507 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2413 2508-2512 NCBITaxon:10088 denotes mice
T2414 2513-2517 GO:0016265 denotes died
T2415 2535-2540 GO:0007567 denotes birth
T2416 2557-2562 PR_EXT:000001683 denotes AVPR2
T2417 2573-2577 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T2418 2578-2582 NCBITaxon_UBERON_EXT:pup denotes pups
T2419 2588-2591 GO:0016265 denotes die
T2420 2620-2625 GO:0007567 denotes birth
T2421 2666-2671 NCBITaxon:10088 denotes mouse
T2422 2698-2706 NCBITaxon:1 denotes organism
T2423 2722-2727 CHEBI:15377 denotes water
T2424 2722-2739 GO:0030104 denotes water homeostasis
T2425 2794-2801 SO_EXT:0000704 denotes genetic
T2426 2812-2817 NCBITaxon:10088 denotes mouse
T2428 2831-2839 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T2429 2907-2913 NCBITaxon:39107 denotes murine
T2430 2933-2944 GO:0001822 denotes nephrogenic
T2431 2977-2985 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T2432 2993-2997 PR_EXT:000004182 denotes Aqp2
T2433 2998-3002 SO_EXT:0000704 denotes gene
T2434 3009-3015 SO_EXT:0001023 denotes allele
T2435 3019-3023 PR_EXT:000004182 denotes Aqp2
T2436 3053-3058 NCBITaxon:10088 denotes mouse
T2437 3106-3110 UBERON:0000104 denotes life
T2438 3112-3121 CHEBI_EXT:polyatomic_entity_or_group denotes Molecular
T2439 3146-3152 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2440 3153-3157 PR_EXT:000004182 denotes AQP2
T2441 3177-3188 GO_UBERON_EXT:cellular_component_or_cell_part denotes subcellular
T2442 3180-3188 CL_GO_EXT:cell denotes cellular
T2443 3189-3201 GO_PATO_EXT:biological_localization_process_or_quality denotes localization
T2444 3205-3226 UBERON:0001232 denotes renal collecting-duct
T2445 3205-3232 CL:1001225 denotes renal collecting-duct cells
T2446 3227-3232 CL_GO_EXT:cell denotes cells
T2447 3255-3268 GO_EXT:biological_translocation_entity_or_process denotes translocation
T2448 3280-3292 CHEBI:4450 denotes desmopressin
T2449 3297-3304 CHEBI_GO_EXT:agonist denotes agonist
T2450 3308-3311 CHEBI_PR_EXT:arginine_vasopressin denotes AVP
T2451 3352-3358 NCBITaxon:9608 denotes canine
T2452 3359-3365 UBERON:0002113 denotes kidney
T2453 3359-3365 _FRAGMENT denotes kidney
T2454 3373-3377 CL:1000497 denotes cell
T2455 3373-3377 CL_GO_EXT:cell denotes cell
T2456 3399-3420 GO:0005783 denotes endoplasmic reticulum
T2457 3437-3443 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2458 3444-3451 CHEBI_PR_EXT:protein denotes protein
T2459 3480-3493 GO_EXT:biological_translocation_entity_or_process denotes translocation
T2460 3530-3539 GO:0030849 denotes autosomal
T2461 3583-3587 PR_EXT:000004182 denotes AQP2
T2462 3588-3595 GO_EXT:biological_routing_or_transport denotes routing
T2463 3610-3616 NCBITaxon:40674 denotes mammal
T2391 1985-1991 GO:0006457 denotes folded
R247 T2329 T2328 _lexicallyChainedTo through,passage
R248 T2330 T2329 _lexicallyChainedTo membrane,through
R249 T2337 T2336 _lexicallyChainedTo in,water reabsorption
R250 T2338 T2337 _lexicallyChainedTo kidney,in
R251 T2346 T2345 _lexicallyChainedTo PM,regions of
R252 T2371 T2370 _lexicallyChainedTo cells,basolateral face of
R253 T2454 T2453 _lexicallyChainedTo cell,kidney

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2195 13-24 GO:0001822 denotes Nephrogenic
T2196 90-99 GO:0060073 denotes urination
T2197 229-230 GO:0000805 denotes X
T2198 274-279 PR:000001683 denotes Avpr2
T2199 280-284 SO:0000704 denotes gene
T2200 293-302 GO:0030849 denotes autosomal
T2201 326-330 PR:000004182 denotes Aqp2
T2202 331-335 SO:0000704 denotes gene
T2203 341-352 PR:000004182 denotes Aquaporin-2
T2204 354-358 PR:000004182 denotes AQP2
T2205 411-416 CHEBI:15377 denotes water
T2206 441-450 GO:0010467 denotes expressed
T2207 454-469 UBERON:0001232 denotes collecting-duct
T2208 454-485 CL:1001431 denotes collecting-duct principal cells
T2209 493-499 UBERON:0002113 denotes kidney
T2210 541-557 GO:0006833 denotes passage of water
T2211 541-548 _FRAGMENT denotes passage
T2212 558-565 _FRAGMENT denotes through
T2213 577-585 GO:0055085 denotes membrane
T2214 552-557 CHEBI:15377 denotes water
T2215 570-585 GO:0005886 denotes plasma membrane
T2216 587-589 GO:0005886 denotes PM
T2217 669-674 CHEBI:15377 denotes water
T2218 669-687 _FRAGMENT denotes water reabsorption
T2219 699-701 _FRAGMENT denotes in
T2220 706-712 GO:0070295 denotes kidney
T2221 693-698 UBERON:0001088 denotes urine
T2222 706-712 UBERON:0002113 denotes kidney
T2223 789-800 GO:0051262 denotes tetramerize
T2224 833-848 GO:0005886 denotes plasma membrane
T2225 931-941 _FRAGMENT denotes regions of
T2226 946-948 GO:0044459 denotes PM
T2227 963-967 PR:000004182 denotes AQP2
T2228 985-1009 GO:0016324 denotes apical membrane of cells
T2229 1026-1041 UBERON:0001232 denotes collecting duct
T2230 1069-1073 PR:000004183 denotes AQP3
T2231 1102-1118 GO:1990794 denotes basolateral face
T2232 1153-1157 PR:000004182 denotes AQP2
T2233 1198-1213 GO:0005886 denotes plasma membrane
T2234 1265-1271 GO:0016324 denotes apical
T2235 1272-1285 GO:0005622 denotes intracellular
T2236 1286-1294 GO:0031982 denotes vesicles
T2237 1332-1337 CHEBI:15377 denotes water
T2238 1348-1352 PR:000004182 denotes AQP2
T2239 1373-1388 GO:0016324 denotes apical membrane
T2240 1401-1406 CHEBI:15377 denotes water
T2241 1478-1483 PR:000001683 denotes AVPR2
T2242 1492-1511 _FRAGMENT denotes basolateral face of
T2243 1532-1537 GO:1990794 denotes cells
T2244 1516-1531 UBERON:0001232 denotes collecting duct
T2245 1516-1537 CL:1001225 denotes collecting duct cells
T2246 1560-1573 GO:0005622 denotes intracellular
T2247 1574-1578 CHEBI:17489 denotes cAMP
T2248 1623-1627 PR:000004182 denotes AQP2
T2249 1645-1649 CHEBI:17489 denotes cAMP
T2250 1709-1724 GO:0005886 denotes plasma membrane
T2251 1744-1748 PR:000004182 denotes AQP2
T2252 1819-1823 PR:000004182 denotes Aqp2
T2253 1861-1867 NCBITaxon:9606 denotes humans
T2254 1886-1890 PR:000004182 denotes Aqp2
T2255 1985-1991 GO:0006457 denotes folded
T2256 1992-1997 CHEBI:15377 denotes water
T2257 2046-2050 CHEBI:17489 denotes cAMP
T2258 2182-2202 GO:0016323 denotes basolateral membrane
T2259 2219-2224 NCBITaxon:10088 denotes mouse
T2260 2313-2318 NCBITaxon:9606 denotes human
T2261 2324-2328 NCBITaxon:10088 denotes mice
T2262 2367-2371 PR:000004182 denotes Aqp2
T2263 2376-2381 PR:000001683 denotes Avpr2
T2264 2421-2426 NCBITaxon:10088 denotes mouse
T2265 2465-2469 PR:000004182 denotes Aqp2
T2266 2470-2474 SO:0000704 denotes gene
T2267 2508-2512 NCBITaxon:10088 denotes mice
T2268 2513-2517 GO:0016265 denotes died
T2269 2535-2540 GO:0007567 denotes birth
T2270 2557-2562 PR:000001683 denotes AVPR2
T2271 2588-2591 GO:0016265 denotes die
T2272 2620-2625 GO:0007567 denotes birth
T2273 2666-2671 NCBITaxon:10088 denotes mouse
T2274 2698-2706 NCBITaxon:1 denotes organism
T2275 2722-2727 CHEBI:15377 denotes water
T2276 2722-2739 GO:0030104 denotes water homeostasis
T2277 2794-2801 SO:0000704 denotes genetic
T2278 2812-2817 NCBITaxon:10088 denotes mouse
T2279 2826-2830 PR:000004182 denotes Aqp2
T2280 2907-2913 NCBITaxon:39107 denotes murine
T2281 2933-2944 GO:0001822 denotes nephrogenic
T2282 2993-2997 PR:000004182 denotes Aqp2
T2283 2998-3002 SO:0000704 denotes gene
T2284 3009-3015 SO:0001023 denotes allele
T2285 3019-3023 PR:000004182 denotes Aqp2
T2286 3053-3058 NCBITaxon:10088 denotes mouse
T2287 3106-3110 UBERON:0000104 denotes life
T2288 3153-3157 PR:000004182 denotes AQP2
T2289 3205-3226 UBERON:0001232 denotes renal collecting-duct
T2290 3205-3232 CL:1001225 denotes renal collecting-duct cells
T2291 3280-3292 CHEBI:4450 denotes desmopressin
T2292 3352-3358 NCBITaxon:9608 denotes canine
T2293 3359-3365 UBERON:0002113 denotes kidney
T2294 3359-3365 _FRAGMENT denotes kidney
T2295 3373-3377 CL:1000497 denotes cell
T2296 3399-3420 GO:0005783 denotes endoplasmic reticulum
T2297 3530-3539 GO:0030849 denotes autosomal
T2298 3583-3587 PR:000004182 denotes AQP2
T2299 3610-3616 NCBITaxon:40674 denotes mammal
R240 T2212 T2211 _lexicallyChainedTo through,passage
R241 T2213 T2212 _lexicallyChainedTo membrane,through
R242 T2219 T2218 _lexicallyChainedTo in,water reabsorption
R243 T2220 T2219 _lexicallyChainedTo kidney,in
R244 T2226 T2225 _lexicallyChainedTo PM,regions of
R245 T2243 T2242 _lexicallyChainedTo cells,basolateral face of
R246 T2295 T2294 _lexicallyChainedTo cell,kidney

craft-sa-dev

Id Subject Object Predicate Lexical cue
T2464 13-24 JJ denotes Nephrogenic
T2465 34-43 NN denotes insipidus
T2466 25-33 NN denotes diabetes
T2467 50-52 VBZ denotes is
T2468 44-45 -LRB- denotes (
T2469 45-48 NN denotes NDI
T2470 48-49 -RRB- denotes )
T2471 53-54 DT denotes a
T2472 55-62 NN denotes disease
T2473 63-76 VBN denotes characterized
T2474 77-79 IN denotes by
T2475 80-89 JJ denotes excessive
T2476 90-99 NN denotes urination
T2477 100-103 CC denotes and
T2478 104-110 RB denotes thirst
T2479 110-112 , denotes ,
T2480 112-119 IN denotes despite
T2481 120-126 JJ denotes normal
T2482 127-137 NN denotes production
T2483 138-140 IN denotes of
T2484 141-144 DT denotes the
T2485 158-165 NN denotes hormone
T2486 145-157 JJ denotes antidiuretic
T2487 166-174 NN denotes arginine
T2488 175-186 NN denotes vasopressin
T2489 187-188 -LRB- denotes (
T2490 188-191 NN denotes AVP
T2491 191-192 -RRB- denotes )
T2492 193-194 -LRB- denotes [
T2493 194-195 CD denotes 1
T2494 195-196 -RRB- denotes ]
T2495 196-197 . denotes .
T2496 197-340 sentence denotes The inherited forms are either X-linked as a consequence of mutation of the Avpr2 gene [2], or autosomal due to mutation of the Aqp2 gene [3].
T2497 198-201 DT denotes The
T2498 212-217 NNS denotes forms
T2499 202-211 VBN denotes inherited
T2500 218-221 VBP denotes are
T2501 222-228 RB denotes either
T2502 231-237 VBN denotes linked
T2503 229-230 NN denotes X
T2504 230-231 HYPH denotes -
T2505 238-240 IN denotes as
T2506 241-242 DT denotes a
T2507 243-254 NN denotes consequence
T2508 255-257 IN denotes of
T2509 258-266 NN denotes mutation
T2510 267-269 IN denotes of
T2511 270-273 DT denotes the
T2512 280-284 NN denotes gene
T2513 274-279 NN denotes Avpr2
T2514 285-286 -LRB- denotes [
T2515 286-287 CD denotes 2
T2516 287-288 -RRB- denotes ]
T2517 288-290 , denotes ,
T2518 290-292 CC denotes or
T2519 293-302 JJ denotes autosomal
T2520 303-306 JJ denotes due
T2521 307-309 IN denotes to
T2522 310-318 NN denotes mutation
T2523 319-321 IN denotes of
T2524 322-325 DT denotes the
T2525 331-335 NN denotes gene
T2526 326-330 NN denotes Aqp2
T2527 336-337 -LRB- denotes [
T2528 337-338 CD denotes 3
T2529 338-339 -RRB- denotes ]
T2530 339-340 . denotes .
T2531 340-504 sentence denotes Aquaporin-2 (AQP2) is a pore-forming protein belonging to a family of water channels [4], and it is expressed in collecting-duct principal cells in the kidney [5].
T2532 341-350 NN denotes Aquaporin
T2533 360-362 VBZ denotes is
T2534 350-351 HYPH denotes -
T2535 351-352 CD denotes 2
T2536 353-354 -LRB- denotes (
T2537 354-358 NN denotes AQP2
T2538 358-359 -RRB- denotes )
T2539 363-364 DT denotes a
T2540 378-385 NN denotes protein
T2541 365-369 NN denotes pore
T2542 370-377 VBG denotes forming
T2543 369-370 HYPH denotes -
T2544 386-395 VBG denotes belonging
T2545 396-398 IN denotes to
T2546 399-400 DT denotes a
T2547 401-407 NN denotes family
T2548 408-410 IN denotes of
T2549 411-416 NN denotes water
T2550 417-425 NNS denotes channels
T2551 426-427 -LRB- denotes [
T2552 427-428 CD denotes 4
T2553 428-429 -RRB- denotes ]
T2554 429-431 , denotes ,
T2555 431-434 CC denotes and
T2556 435-437 PRP denotes it
T2557 441-450 VBN denotes expressed
T2558 438-440 VBZ denotes is
T2559 451-453 IN denotes in
T2560 454-464 VBG denotes collecting
T2561 465-469 NN denotes duct
T2562 464-465 HYPH denotes -
T2563 480-485 NNS denotes cells
T2564 470-479 JJ denotes principal
T2565 486-488 IN denotes in
T2566 489-492 DT denotes the
T2567 493-499 NN denotes kidney
T2568 500-501 -LRB- denotes [
T2569 501-502 CD denotes 5
T2570 502-503 -RRB- denotes ]
T2571 503-504 . denotes .
T2572 504-713 sentence denotes Generally these proteins permit the passage of water through the plasma membrane (PM) of cells, several of which carry out this role specifically in the process of water reabsorption from urine in the kidney.
T2573 505-514 RB denotes Generally
T2574 530-536 VBP denotes permit
T2575 515-520 DT denotes these
T2576 521-529 NN denotes proteins
T2577 537-540 DT denotes the
T2578 541-548 NN denotes passage
T2579 549-551 IN denotes of
T2580 552-557 NN denotes water
T2581 558-565 IN denotes through
T2582 566-569 DT denotes the
T2583 577-585 NN denotes membrane
T2584 570-576 NN denotes plasma
T2585 586-587 -LRB- denotes (
T2586 587-589 NN denotes PM
T2587 589-590 -RRB- denotes )
T2588 591-593 IN denotes of
T2589 594-599 NNS denotes cells
T2590 599-601 , denotes ,
T2591 601-608 JJ denotes several
T2592 618-623 VBP denotes carry
T2593 609-611 IN denotes of
T2594 612-617 WDT denotes which
T2595 624-627 RP denotes out
T2596 628-632 DT denotes this
T2597 633-637 NN denotes role
T2598 638-650 RB denotes specifically
T2599 651-653 IN denotes in
T2600 654-657 DT denotes the
T2601 658-665 NN denotes process
T2602 666-668 IN denotes of
T2603 669-674 NN denotes water
T2604 675-687 NN denotes reabsorption
T2605 688-692 IN denotes from
T2606 693-698 NN denotes urine
T2607 699-701 IN denotes in
T2608 702-705 DT denotes the
T2609 706-712 NN denotes kidney
T2610 712-713 . denotes .
T2611 713-855 sentence denotes It has been established that aquaporins, although functional as a monomer, tetramerize before their insertion into the plasma membrane [4,6].
T2612 714-716 PRP denotes It
T2613 726-737 VBN denotes established
T2614 717-720 VBZ denotes has
T2615 721-725 VBN denotes been
T2616 738-742 IN denotes that
T2617 789-800 VBP denotes tetramerize
T2618 743-753 NNS denotes aquaporins
T2619 753-755 , denotes ,
T2620 755-763 IN denotes although
T2621 764-774 JJ denotes functional
T2622 775-777 IN denotes as
T2623 778-779 DT denotes a
T2624 780-787 NN denotes monomer
T2625 787-789 , denotes ,
T2626 801-807 IN denotes before
T2627 808-813 PRP$ denotes their
T2628 814-823 NN denotes insertion
T2629 824-828 IN denotes into
T2630 829-832 DT denotes the
T2631 840-848 NN denotes membrane
T2632 833-839 NN denotes plasma
T2633 849-850 -LRB- denotes [
T2634 852-853 CD denotes 6
T2635 850-851 CD denotes 4
T2636 851-852 , denotes ,
T2637 853-854 -RRB- denotes ]
T2638 854-855 . denotes .
T2639 855-1119 sentence denotes Furthermore these proteins can also be differentially targeted to distinct regions of the PM; for example, AQP2 is routed to the apical membrane of cells surrounding the collecting duct, whereas other aquaporins (AQP3 or 4) are inserted into the basolateral face.
T2640 856-867 RB denotes Furthermore
T2641 910-918 VBN denotes targeted
T2642 868-873 DT denotes these
T2643 874-882 NN denotes proteins
T2644 883-886 MD denotes can
T2645 887-891 RB denotes also
T2646 892-894 VB denotes be
T2647 895-909 RB denotes differentially
T2648 971-977 VBN denotes routed
T2649 919-921 IN denotes to
T2650 922-930 JJ denotes distinct
T2651 931-938 NNS denotes regions
T2652 939-941 IN denotes of
T2653 942-945 DT denotes the
T2654 946-948 NN denotes PM
T2655 948-949 : denotes ;
T2656 950-953 IN denotes for
T2657 954-961 NN denotes example
T2658 961-963 , denotes ,
T2659 963-967 NN denotes AQP2
T2660 968-970 VBZ denotes is
T2661 978-980 IN denotes to
T2662 981-984 DT denotes the
T2663 992-1000 NN denotes membrane
T2664 985-991 JJ denotes apical
T2665 1001-1003 IN denotes of
T2666 1004-1009 NNS denotes cells
T2667 1010-1021 VBG denotes surrounding
T2668 1022-1025 DT denotes the
T2669 1037-1041 NN denotes duct
T2670 1026-1036 VBG denotes collecting
T2671 1041-1043 , denotes ,
T2672 1043-1050 IN denotes whereas
T2673 1084-1092 VBN denotes inserted
T2674 1051-1056 JJ denotes other
T2675 1057-1067 NNS denotes aquaporins
T2676 1068-1069 -LRB- denotes (
T2677 1069-1073 NN denotes AQP3
T2678 1074-1076 CC denotes or
T2679 1077-1078 CD denotes 4
T2680 1078-1079 -RRB- denotes )
T2681 1080-1083 VBP denotes are
T2682 1093-1097 IN denotes into
T2683 1098-1101 DT denotes the
T2684 1114-1118 NN denotes face
T2685 1102-1113 JJ denotes basolateral
T2686 1118-1119 . denotes .
T2687 1119-1214 sentence denotes Unlike all other family members, AQP2 is not constitutively inserted into the plasma membrane.
T2688 1120-1126 IN denotes Unlike
T2689 1180-1188 VBN denotes inserted
T2690 1127-1130 DT denotes all
T2691 1144-1151 NNS denotes members
T2692 1131-1136 JJ denotes other
T2693 1137-1143 NN denotes family
T2694 1151-1153 , denotes ,
T2695 1153-1157 NN denotes AQP2
T2696 1158-1160 VBZ denotes is
T2697 1161-1164 RB denotes not
T2698 1165-1179 RB denotes constitutively
T2699 1189-1193 IN denotes into
T2700 1194-1197 DT denotes the
T2701 1205-1213 NN denotes membrane
T2702 1198-1204 NN denotes plasma
T2703 1213-1214 . denotes .
T2704 1214-1426 sentence denotes Under basal conditions, the protein resides in subapical intracellular vesicles; however, under conditions requiring water retention AQP2 translocates to the apical membrane, permitting water reabsorption [7,8].
T2705 1215-1220 IN denotes Under
T2706 1251-1258 VBZ denotes resides
T2707 1221-1226 JJ denotes basal
T2708 1227-1237 NNS denotes conditions
T2709 1237-1239 , denotes ,
T2710 1239-1242 DT denotes the
T2711 1243-1250 NN denotes protein
T2712 1353-1365 VBZ denotes translocates
T2713 1259-1261 IN denotes in
T2714 1262-1271 JJ denotes subapical
T2715 1286-1294 NNS denotes vesicles
T2716 1272-1285 JJ denotes intracellular
T2717 1294-1295 : denotes ;
T2718 1296-1303 RB denotes however
T2719 1303-1305 , denotes ,
T2720 1305-1310 IN denotes under
T2721 1311-1321 NNS denotes conditions
T2722 1322-1331 VBG denotes requiring
T2723 1332-1337 NN denotes water
T2724 1338-1347 NN denotes retention
T2725 1348-1352 NN denotes AQP2
T2726 1366-1368 IN denotes to
T2727 1369-1372 DT denotes the
T2728 1380-1388 NN denotes membrane
T2729 1373-1379 JJ denotes apical
T2730 1388-1390 , denotes ,
T2731 1390-1400 VBG denotes permitting
T2732 1401-1406 NN denotes water
T2733 1407-1419 NN denotes reabsorption
T2734 1420-1421 -LRB- denotes [
T2735 1423-1424 CD denotes 8
T2736 1421-1422 CD denotes 7
T2737 1422-1423 , denotes ,
T2738 1424-1425 -RRB- denotes ]
T2739 1425-1426 . denotes .
T2740 1426-1725 sentence denotes For this process to occur, AVP binds its receptor, AVPR2, on the basolateral face of the collecting duct cells, leading to a rise in intracellular cAMP, ultimately resulting in phosphorylation of AQP2 at serine 256 by cAMP-dependent protein kinase [9] and its redistribution to the plasma membrane.
T2741 1427-1430 IN denotes For
T2742 1447-1452 VB denotes occur
T2743 1431-1435 DT denotes this
T2744 1436-1443 NN denotes process
T2745 1444-1446 TO denotes to
T2746 1458-1463 VBZ denotes binds
T2747 1452-1454 , denotes ,
T2748 1454-1457 NN denotes AVP
T2749 1464-1467 PRP$ denotes its
T2750 1468-1476 NN denotes receptor
T2751 1476-1478 , denotes ,
T2752 1478-1483 NN denotes AVPR2
T2753 1483-1485 , denotes ,
T2754 1485-1487 IN denotes on
T2755 1488-1491 DT denotes the
T2756 1504-1508 NN denotes face
T2757 1492-1503 JJ denotes basolateral
T2758 1509-1511 IN denotes of
T2759 1512-1515 DT denotes the
T2760 1532-1537 NNS denotes cells
T2761 1516-1526 VBG denotes collecting
T2762 1527-1531 NN denotes duct
T2763 1537-1539 , denotes ,
T2764 1539-1546 VBG denotes leading
T2765 1547-1549 IN denotes to
T2766 1550-1551 DT denotes a
T2767 1552-1556 NN denotes rise
T2768 1557-1559 IN denotes in
T2769 1560-1573 JJ denotes intracellular
T2770 1574-1578 NN denotes cAMP
T2771 1578-1580 , denotes ,
T2772 1580-1590 RB denotes ultimately
T2773 1591-1600 VBG denotes resulting
T2774 1601-1603 IN denotes in
T2775 1604-1619 NN denotes phosphorylation
T2776 1620-1622 IN denotes of
T2777 1623-1627 NN denotes AQP2
T2778 1628-1630 IN denotes at
T2779 1631-1637 NN denotes serine
T2780 1638-1641 CD denotes 256
T2781 1642-1644 IN denotes by
T2782 1645-1649 NN denotes cAMP
T2783 1650-1659 JJ denotes dependent
T2784 1649-1650 HYPH denotes -
T2785 1668-1674 NN denotes kinase
T2786 1660-1667 NN denotes protein
T2787 1675-1676 -LRB- denotes [
T2788 1676-1677 CD denotes 9
T2789 1677-1678 -RRB- denotes ]
T2790 1679-1682 CC denotes and
T2791 1683-1686 PRP$ denotes its
T2792 1687-1701 NN denotes redistribution
T2793 1702-1704 IN denotes to
T2794 1705-1708 DT denotes the
T2795 1716-1724 NN denotes membrane
T2796 1709-1715 NN denotes plasma
T2797 1724-1725 . denotes .
T2798 1725-1875 sentence denotes The importance of AQP2 redistribution has been highlighted by functional characterization of Aqp2 mutations resulting in severe NDI in humans [3,10].
T2799 1726-1729 DT denotes The
T2800 1730-1740 NN denotes importance
T2801 1773-1784 VBN denotes highlighted
T2802 1741-1743 IN denotes of
T2803 1744-1748 NN denotes AQP2
T2804 1749-1763 NN denotes redistribution
T2805 1764-1767 VBZ denotes has
T2806 1768-1772 VBN denotes been
T2807 1785-1787 IN denotes by
T2808 1788-1798 JJ denotes functional
T2809 1799-1815 NN denotes characterization
T2810 1816-1818 IN denotes of
T2811 1819-1823 NN denotes Aqp2
T2812 1824-1833 NNS denotes mutations
T2813 1834-1843 VBG denotes resulting
T2814 1844-1846 IN denotes in
T2815 1847-1853 JJ denotes severe
T2816 1854-1857 NN denotes NDI
T2817 1858-1860 IN denotes in
T2818 1861-1867 NNS denotes humans
T2819 1868-1869 -LRB- denotes [
T2820 1871-1873 CD denotes 10
T2821 1869-1870 CD denotes 3
T2822 1870-1871 , denotes ,
T2823 1873-1874 -RRB- denotes ]
T2824 1874-1875 . denotes .
T2825 1875-2058 sentence denotes Recessive Aqp2 mutations are generally thought to produce an abnormally localized and, in most instances, misfolded water pore that responds abnormally to an increase in cAMP [6,11].
T2826 1876-1885 JJ denotes Recessive
T2827 1891-1900 NNS denotes mutations
T2828 1886-1890 NN denotes Aqp2
T2829 1915-1922 VBN denotes thought
T2830 1901-1904 VBP denotes are
T2831 1905-1914 RB denotes generally
T2832 1923-1925 TO denotes to
T2833 1926-1933 VB denotes produce
T2834 1934-1936 DT denotes an
T2835 1998-2002 NN denotes pore
T2836 1937-1947 RB denotes abnormally
T2837 1948-1957 VBN denotes localized
T2838 1958-1961 CC denotes and
T2839 1961-1963 , denotes ,
T2840 1982-1991 VBN denotes misfolded
T2841 1963-1965 IN denotes in
T2842 1966-1970 JJS denotes most
T2843 1971-1980 NNS denotes instances
T2844 1980-1982 , denotes ,
T2845 1992-1997 NN denotes water
T2846 2003-2007 WDT denotes that
T2847 2008-2016 VBZ denotes responds
T2848 2017-2027 RB denotes abnormally
T2849 2028-2030 IN denotes to
T2850 2031-2033 DT denotes an
T2851 2034-2042 NN denotes increase
T2852 2043-2045 IN denotes in
T2853 2046-2050 NN denotes cAMP
T2854 2051-2052 -LRB- denotes [
T2855 2054-2056 CD denotes 11
T2856 2052-2053 CD denotes 6
T2857 2053-2054 , denotes ,
T2858 2056-2057 -RRB- denotes ]
T2859 2057-2058 . denotes .
T2860 2058-2210 sentence denotes Furthermore, dominant mutations have been described and found to misroute both the mutant and the wild-type protein to the basolateral membrane [6,12].
T2861 2059-2070 RB denotes Furthermore
T2862 2101-2110 VBN denotes described
T2863 2070-2072 , denotes ,
T2864 2072-2080 JJ denotes dominant
T2865 2081-2090 NNS denotes mutations
T2866 2091-2095 VBP denotes have
T2867 2096-2100 VBN denotes been
T2868 2111-2114 CC denotes and
T2869 2115-2120 VBN denotes found
T2870 2121-2123 TO denotes to
T2871 2124-2132 VB denotes misroute
T2872 2133-2137 CC denotes both
T2873 2142-2148 NN denotes mutant
T2874 2138-2141 DT denotes the
T2875 2149-2152 CC denotes and
T2876 2153-2156 DT denotes the
T2877 2162-2166 NN denotes type
T2878 2157-2161 JJ denotes wild
T2879 2161-2162 HYPH denotes -
T2880 2167-2174 NN denotes protein
T2881 2175-2177 IN denotes to
T2882 2178-2181 DT denotes the
T2883 2194-2202 NN denotes membrane
T2884 2182-2193 JJ denotes basolateral
T2885 2203-2204 -LRB- denotes [
T2886 2206-2208 CD denotes 12
T2887 2204-2205 CD denotes 6
T2888 2205-2206 , denotes ,
T2889 2208-2209 -RRB- denotes ]
T2890 2209-2210 . denotes .
T2891 2210-2282 sentence denotes Several mouse models of diabetes insipidus have been generated [13–17].
T2892 2211-2218 JJ denotes Several
T2893 2225-2231 NNS denotes models
T2894 2219-2224 NN denotes mouse
T2895 2264-2273 VBN denotes generated
T2896 2232-2234 IN denotes of
T2897 2235-2243 NN denotes diabetes
T2898 2244-2253 NN denotes insipidus
T2899 2254-2258 VBP denotes have
T2900 2259-2263 VBN denotes been
T2901 2274-2275 -LRB- denotes [
T2902 2275-2277 CD denotes 13
T2903 2277-2278 SYM denotes –
T2904 2278-2280 CD denotes 17
T2905 2280-2281 -RRB- denotes ]
T2906 2281-2282 . denotes .
T2907 2282-2390 sentence denotes In an attempt to recapitulate human NDI, mice have been generated with mutations in Aqp2 and Avpr2 [15,18].
T2908 2283-2285 IN denotes In
T2909 2339-2348 VBN denotes generated
T2910 2286-2288 DT denotes an
T2911 2289-2296 NN denotes attempt
T2912 2297-2299 TO denotes to
T2913 2300-2312 VB denotes recapitulate
T2914 2313-2318 JJ denotes human
T2915 2319-2322 NN denotes NDI
T2916 2322-2324 , denotes ,
T2917 2324-2328 NNS denotes mice
T2918 2329-2333 VBP denotes have
T2919 2334-2338 VBN denotes been
T2920 2349-2353 IN denotes with
T2921 2354-2363 NNS denotes mutations
T2922 2364-2366 IN denotes in
T2923 2367-2371 NN denotes Aqp2
T2924 2372-2375 CC denotes and
T2925 2376-2381 NN denotes Avpr2
T2926 2382-2383 -LRB- denotes [
T2927 2386-2388 CD denotes 18
T2928 2383-2385 CD denotes 15
T2929 2385-2386 , denotes ,
T2930 2388-2389 -RRB- denotes ]
T2931 2389-2390 . denotes .
T2932 2390-2475 sentence denotes Yang and colleagues created a mouse with a T126M knock-in mutation in the Aqp2 gene.
T2933 2391-2395 NNP denotes Yang
T2934 2411-2418 VBD denotes created
T2935 2396-2399 CC denotes and
T2936 2400-2410 NNS denotes colleagues
T2937 2419-2420 DT denotes a
T2938 2421-2426 NN denotes mouse
T2939 2427-2431 IN denotes with
T2940 2432-2433 DT denotes a
T2941 2449-2457 NN denotes mutation
T2942 2434-2439 NN denotes T126M
T2943 2440-2445 VB denotes knock
T2944 2445-2446 HYPH denotes -
T2945 2446-2448 RP denotes in
T2946 2458-2460 IN denotes in
T2947 2461-2464 DT denotes the
T2948 2470-2474 NN denotes gene
T2949 2465-2469 NN denotes Aqp2
T2950 2474-2475 . denotes .
T2951 2475-2541 sentence denotes Unexpectedly, homozygous mutant mice died within 6 d after birth.
T2952 2476-2488 RB denotes Unexpectedly
T2953 2513-2517 VBD denotes died
T2954 2488-2490 , denotes ,
T2955 2490-2500 JJ denotes homozygous
T2956 2508-2512 NNS denotes mice
T2957 2501-2507 NN denotes mutant
T2958 2518-2524 IN denotes within
T2959 2525-2526 CD denotes 6
T2960 2527-2528 NNS denotes d
T2961 2529-2534 IN denotes after
T2962 2535-2540 NN denotes birth
T2963 2540-2541 . denotes .
T2964 2541-2626 sentence denotes Interestingly, AVPR2-deficient male pups also die within the first week after birth.
T2965 2542-2555 RB denotes Interestingly
T2966 2588-2591 VBP denotes die
T2967 2555-2557 , denotes ,
T2968 2557-2562 NN denotes AVPR2
T2969 2563-2572 JJ denotes deficient
T2970 2562-2563 HYPH denotes -
T2971 2578-2582 NNS denotes pups
T2972 2573-2577 JJ denotes male
T2973 2583-2587 RB denotes also
T2974 2592-2598 IN denotes within
T2975 2599-2602 DT denotes the
T2976 2609-2613 NN denotes week
T2977 2603-2608 JJ denotes first
T2978 2614-2619 IN denotes after
T2979 2620-2625 NN denotes birth
T2980 2625-2626 . denotes .
T2981 2626-2780 sentence denotes Together these models suggest that the mouse may be a highly sensitive organism with regard to water homeostasis, and is unable to survive with polyuria.
T2982 2627-2635 RB denotes Together
T2983 2649-2656 VBP denotes suggest
T2984 2636-2641 DT denotes these
T2985 2642-2648 NNS denotes models
T2986 2657-2661 IN denotes that
T2987 2676-2678 VB denotes be
T2988 2662-2665 DT denotes the
T2989 2666-2671 NN denotes mouse
T2990 2672-2675 MD denotes may
T2991 2679-2680 DT denotes a
T2992 2698-2706 NN denotes organism
T2993 2681-2687 RB denotes highly
T2994 2688-2697 JJ denotes sensitive
T2995 2707-2711 IN denotes with
T2996 2712-2718 NN denotes regard
T2997 2719-2721 IN denotes to
T2998 2722-2727 NN denotes water
T2999 2728-2739 NN denotes homeostasis
T3000 2739-2741 , denotes ,
T3001 2741-2744 CC denotes and
T3002 2745-2747 VBZ denotes is
T3003 2748-2754 JJ denotes unable
T3004 2755-2757 TO denotes to
T3005 2758-2765 VB denotes survive
T3006 2766-2770 IN denotes with
T3007 2771-2779 NN denotes polyuria
T3008 2779-2780 . denotes .
T3009 2780-2855 sentence denotes In a forward genetic screen, a mouse with an Aqp2 mutation was identified.
T3010 2781-2783 IN denotes In
T3011 2844-2854 VBN denotes identified
T3012 2784-2785 DT denotes a
T3013 2802-2808 NN denotes screen
T3014 2786-2793 RB denotes forward
T3015 2794-2801 JJ denotes genetic
T3016 2808-2810 , denotes ,
T3017 2810-2811 DT denotes a
T3018 2812-2817 NN denotes mouse
T3019 2818-2822 IN denotes with
T3020 2823-2825 DT denotes an
T3021 2831-2839 NN denotes mutation
T3022 2826-2830 NN denotes Aqp2
T3023 2840-2843 VBD denotes was
T3024 2854-2855 . denotes .
T3025 2855-2948 sentence denotes The purpose of this study was to characterize this murine model of recessive nephrogenic DI.
T3026 2856-2859 DT denotes The
T3027 2860-2867 NN denotes purpose
T3028 2882-2885 VBD denotes was
T3029 2868-2870 IN denotes of
T3030 2871-2875 DT denotes this
T3031 2876-2881 NN denotes study
T3032 2886-2888 TO denotes to
T3033 2889-2901 VB denotes characterize
T3034 2902-2906 DT denotes this
T3035 2914-2919 NN denotes model
T3036 2907-2913 JJ denotes murine
T3037 2920-2922 IN denotes of
T3038 2923-2932 JJ denotes recessive
T3039 2945-2947 NN denotes DI
T3040 2933-2944 JJ denotes nephrogenic
T3041 2947-2948 . denotes .
T3042 2948-3003 sentence denotes We now report a novel F204V mutation in the Aqp2 gene.
T3043 2949-2951 PRP denotes We
T3044 2956-2962 VBP denotes report
T3045 2952-2955 RB denotes now
T3046 2963-2964 DT denotes a
T3047 2977-2985 NN denotes mutation
T3048 2965-2970 JJ denotes novel
T3049 2971-2976 NN denotes F204V
T3050 2986-2988 IN denotes in
T3051 2989-2992 DT denotes the
T3052 2998-3002 NN denotes gene
T3053 2993-2997 NN denotes Aqp2
T3054 3002-3003 . denotes .
T3055 3003-3111 sentence denotes This allele of Aqp2 was found to cause the first mouse model of NDI to survive past the first week of life.
T3056 3004-3008 DT denotes This
T3057 3009-3015 NN denotes allele
T3058 3028-3033 VBN denotes found
T3059 3016-3018 IN denotes of
T3060 3019-3023 NN denotes Aqp2
T3061 3024-3027 VBD denotes was
T3062 3034-3036 TO denotes to
T3063 3037-3042 VB denotes cause
T3064 3043-3046 DT denotes the
T3065 3059-3064 NN denotes model
T3066 3047-3052 JJ denotes first
T3067 3053-3058 NN denotes mouse
T3068 3075-3082 VB denotes survive
T3069 3065-3067 IN denotes of
T3070 3068-3071 NN denotes NDI
T3071 3072-3074 TO denotes to
T3072 3083-3087 IN denotes past
T3073 3088-3091 DT denotes the
T3074 3098-3102 NN denotes week
T3075 3092-3097 JJ denotes first
T3076 3103-3105 IN denotes of
T3077 3106-3110 NN denotes life
T3078 3110-3111 . denotes .
T3079 3111-3312 sentence denotes Molecular analyses concluded that mutant AQP2 adopts a different subcellular localization in renal collecting-duct cells, and was resistant to translocation induced by desmopressin, an agonist of AVP.
T3080 3112-3121 JJ denotes Molecular
T3081 3122-3130 NNS denotes analyses
T3082 3131-3140 VBD denotes concluded
T3083 3141-3145 IN denotes that
T3084 3158-3164 VBZ denotes adopts
T3085 3146-3152 NN denotes mutant
T3086 3153-3157 NN denotes AQP2
T3087 3165-3166 DT denotes a
T3088 3189-3201 NN denotes localization
T3089 3167-3176 JJ denotes different
T3090 3177-3188 JJ denotes subcellular
T3091 3202-3204 IN denotes in
T3092 3205-3210 JJ denotes renal
T3093 3227-3232 NNS denotes cells
T3094 3211-3221 VBG denotes collecting
T3095 3222-3226 NN denotes duct
T3096 3221-3222 HYPH denotes -
T3097 3232-3234 , denotes ,
T3098 3234-3237 CC denotes and
T3099 3238-3241 VBD denotes was
T3100 3242-3251 JJ denotes resistant
T3101 3252-3254 IN denotes to
T3102 3255-3268 NN denotes translocation
T3103 3269-3276 VBN denotes induced
T3104 3277-3279 IN denotes by
T3105 3280-3292 NN denotes desmopressin
T3106 3292-3294 , denotes ,
T3107 3294-3296 DT denotes an
T3108 3297-3304 NN denotes agonist
T3109 3305-3307 IN denotes of
T3110 3308-3311 NN denotes AVP
T3111 3311-3312 . denotes .
T3112 3312-3494 sentence denotes In vitro studies using the Madin-Darby canine kidney (MDCK) cell line demonstrated an endoplasmic reticulum pattern for the mutant protein, and apparent resistance to translocation.
T3113 3313-3315 FW denotes In
T3114 3316-3321 FW denotes vitro
T3115 3322-3329 NNS denotes studies
T3116 3383-3395 VBD denotes demonstrated
T3117 3330-3335 VBG denotes using
T3118 3336-3339 DT denotes the
T3119 3378-3382 NN denotes line
T3120 3340-3345 NN denotes Madin
T3121 3346-3351 NN denotes Darby
T3122 3345-3346 HYPH denotes -
T3123 3359-3365 NN denotes kidney
T3124 3352-3358 JJ denotes canine
T3125 3366-3367 -LRB- denotes (
T3126 3367-3371 NN denotes MDCK
T3127 3371-3372 -RRB- denotes )
T3128 3373-3377 NN denotes cell
T3129 3396-3398 DT denotes an
T3130 3421-3428 NN denotes pattern
T3131 3399-3410 JJ denotes endoplasmic
T3132 3411-3420 NN denotes reticulum
T3133 3429-3432 IN denotes for
T3134 3433-3436 DT denotes the
T3135 3444-3451 NN denotes protein
T3136 3437-3443 NN denotes mutant
T3137 3451-3453 , denotes ,
T3138 3453-3456 CC denotes and
T3139 3457-3465 JJ denotes apparent
T3140 3466-3476 NN denotes resistance
T3141 3477-3479 IN denotes to
T3142 3480-3493 NN denotes translocation
T3143 3493-3494 . denotes .
T3144 3494-3617 sentence denotes These data conclusively prove that autosomal recessive NDI is a consequence of improper AQP2 routing in the intact mammal.
T3145 3495-3500 DT denotes These
T3146 3501-3505 NNS denotes data
T3147 3519-3524 VBP denotes prove
T3148 3506-3518 RB denotes conclusively
T3149 3525-3529 IN denotes that
T3150 3554-3556 VBZ denotes is
T3151 3530-3539 JJ denotes autosomal
T3152 3550-3553 NN denotes NDI
T3153 3540-3549 JJ denotes recessive
T3154 3557-3558 DT denotes a
T3155 3559-3570 NN denotes consequence
T3156 3571-3573 IN denotes of
T3157 3574-3582 JJ denotes improper
T3158 3588-3595 NN denotes routing
T3159 3583-3587 NN denotes AQP2
T3160 3596-3598 IN denotes in
T3161 3599-3602 DT denotes the
T3162 3610-3616 NN denotes mammal
T3163 3603-3609 JJ denotes intact
T3164 3616-3617 . denotes .
R254 T2464 T2465 amod Nephrogenic,insipidus
R255 T2465 T2467 nsubj insipidus,is
R256 T2466 T2465 compound diabetes,insipidus
R257 T2468 T2465 punct (,insipidus
R258 T2469 T2465 appos NDI,insipidus
R259 T2470 T2467 punct ),is
R260 T2471 T2472 det a,disease
R261 T2472 T2467 attr disease,is
R262 T2473 T2472 acl characterized,disease
R263 T2474 T2473 agent by,characterized
R264 T2475 T2476 amod excessive,urination
R265 T2476 T2474 pobj urination,by
R266 T2477 T2476 cc and,urination
R267 T2478 T2476 conj thirst,urination
R268 T2479 T2473 punct ", ",characterized
R269 T2480 T2473 prep despite,characterized
R270 T2481 T2482 amod normal,production
R271 T2482 T2480 pobj production,despite
R272 T2483 T2482 prep of,production
R273 T2484 T2485 det the,hormone
R274 T2485 T2483 pobj hormone,of
R275 T2486 T2485 amod antidiuretic,hormone
R276 T2487 T2488 compound arginine,vasopressin
R277 T2488 T2485 appos vasopressin,hormone
R278 T2489 T2488 punct (,vasopressin
R279 T2490 T2488 appos AVP,vasopressin
R280 T2491 T2467 punct ),is
R281 T2492 T2493 punct [,1
R282 T2493 T2467 parataxis 1,is
R283 T2494 T2493 punct ],1
R284 T2495 T2467 punct .,is
R285 T2497 T2498 det The,forms
R286 T2498 T2500 nsubj forms,are
R287 T2499 T2498 amod inherited,forms
R288 T2501 T2502 advmod either,linked
R289 T2502 T2500 acomp linked,are
R290 T2503 T2502 npadvmod X,linked
R291 T2504 T2502 punct -,linked
R292 T2505 T2502 prep as,linked
R293 T2506 T2507 det a,consequence
R294 T2507 T2505 pobj consequence,as
R295 T2508 T2507 prep of,consequence
R296 T2509 T2508 pobj mutation,of
R297 T2510 T2509 prep of,mutation
R298 T2511 T2512 det the,gene
R299 T2512 T2510 pobj gene,of
R300 T2513 T2512 compound Avpr2,gene
R301 T2514 T2515 punct [,2
R302 T2515 T2502 parataxis 2,linked
R303 T2516 T2515 punct ],2
R304 T2517 T2502 punct ", ",linked
R305 T2518 T2502 cc or,linked
R306 T2519 T2502 conj autosomal,linked
R307 T2520 T2521 amod due,to
R308 T2521 T2519 prep to,autosomal
R309 T2522 T2521 pobj mutation,to
R310 T2523 T2522 prep of,mutation
R311 T2524 T2525 det the,gene
R312 T2525 T2523 pobj gene,of
R313 T2526 T2525 compound Aqp2,gene
R314 T2527 T2528 punct [,3
R315 T2528 T2519 parataxis 3,autosomal
R316 T2529 T2528 punct ],3
R317 T2530 T2500 punct .,are
R318 T2532 T2533 nsubj Aquaporin,is
R319 T2534 T2532 punct -,Aquaporin
R320 T2535 T2532 nummod 2,Aquaporin
R321 T2536 T2532 punct (,Aquaporin
R322 T2537 T2532 appos AQP2,Aquaporin
R323 T2538 T2533 punct ),is
R324 T2539 T2540 det a,protein
R325 T2540 T2533 attr protein,is
R326 T2541 T2542 npadvmod pore,forming
R327 T2542 T2540 amod forming,protein
R328 T2543 T2542 punct -,forming
R329 T2544 T2540 acl belonging,protein
R330 T2545 T2544 prep to,belonging
R331 T2546 T2547 det a,family
R332 T2547 T2545 pobj family,to
R333 T2548 T2547 prep of,family
R334 T2549 T2550 compound water,channels
R335 T2550 T2548 pobj channels,of
R336 T2551 T2552 punct [,4
R337 T2552 T2533 parataxis 4,is
R338 T2553 T2552 punct ],4
R339 T2554 T2533 punct ", ",is
R340 T2555 T2533 cc and,is
R341 T2556 T2557 nsubjpass it,expressed
R342 T2557 T2533 conj expressed,is
R343 T2558 T2557 auxpass is,expressed
R344 T2559 T2557 prep in,expressed
R345 T2560 T2561 amod collecting,duct
R346 T2561 T2563 nmod duct,cells
R347 T2562 T2561 punct -,duct
R348 T2563 T2559 pobj cells,in
R349 T2564 T2563 amod principal,cells
R350 T2565 T2557 prep in,expressed
R351 T2566 T2567 det the,kidney
R352 T2567 T2565 pobj kidney,in
R353 T2568 T2569 punct [,5
R354 T2569 T2557 parataxis 5,expressed
R355 T2570 T2569 punct ],5
R356 T2571 T2557 punct .,expressed
R357 T2573 T2574 advmod Generally,permit
R358 T2575 T2576 det these,proteins
R359 T2576 T2574 nsubj proteins,permit
R360 T2577 T2578 det the,passage
R361 T2578 T2574 dobj passage,permit
R362 T2579 T2578 prep of,passage
R363 T2580 T2579 pobj water,of
R364 T2581 T2578 prep through,passage
R365 T2582 T2583 det the,membrane
R366 T2583 T2581 pobj membrane,through
R367 T2584 T2583 compound plasma,membrane
R368 T2585 T2583 punct (,membrane
R369 T2586 T2583 appos PM,membrane
R370 T2587 T2583 punct ),membrane
R371 T2588 T2583 prep of,membrane
R372 T2589 T2588 pobj cells,of
R373 T2590 T2589 punct ", ",cells
R374 T2591 T2592 dep several,carry
R375 T2592 T2589 relcl carry,cells
R376 T2593 T2591 prep of,several
R377 T2594 T2593 pobj which,of
R378 T2595 T2592 prt out,carry
R379 T2596 T2597 det this,role
R380 T2597 T2592 dobj role,carry
R381 T2598 T2599 advmod specifically,in
R382 T2599 T2592 prep in,carry
R383 T2600 T2601 det the,process
R384 T2601 T2599 pobj process,in
R385 T2602 T2601 prep of,process
R386 T2603 T2604 compound water,reabsorption
R387 T2604 T2602 pobj reabsorption,of
R388 T2605 T2604 prep from,reabsorption
R389 T2606 T2605 pobj urine,from
R390 T2607 T2604 prep in,reabsorption
R391 T2608 T2609 det the,kidney
R392 T2609 T2607 pobj kidney,in
R393 T2610 T2574 punct .,permit
R394 T2612 T2613 nsubjpass It,established
R395 T2614 T2613 aux has,established
R396 T2615 T2613 auxpass been,established
R397 T2616 T2617 mark that,tetramerize
R398 T2617 T2613 ccomp tetramerize,established
R399 T2618 T2617 nsubj aquaporins,tetramerize
R400 T2619 T2617 punct ", ",tetramerize
R401 T2620 T2621 mark although,functional
R402 T2621 T2617 advcl functional,tetramerize
R403 T2622 T2621 prep as,functional
R404 T2623 T2624 det a,monomer
R405 T2624 T2622 pobj monomer,as
R406 T2625 T2617 punct ", ",tetramerize
R407 T2626 T2617 prep before,tetramerize
R408 T2627 T2628 poss their,insertion
R409 T2628 T2626 pobj insertion,before
R410 T2629 T2628 prep into,insertion
R411 T2630 T2631 det the,membrane
R412 T2631 T2629 pobj membrane,into
R413 T2632 T2631 compound plasma,membrane
R414 T2633 T2634 punct [,6
R415 T2634 T2613 parataxis 6,established
R416 T2635 T2634 nummod 4,6
R417 T2636 T2634 punct ",",6
R418 T2637 T2634 punct ],6
R419 T2638 T2613 punct .,established
R420 T2640 T2641 advmod Furthermore,targeted
R421 T2641 T2648 ccomp targeted,routed
R422 T2642 T2643 det these,proteins
R423 T2643 T2641 nsubjpass proteins,targeted
R424 T2644 T2641 aux can,targeted
R425 T2645 T2641 advmod also,targeted
R426 T2646 T2641 auxpass be,targeted
R427 T2647 T2641 advmod differentially,targeted
R428 T2649 T2641 prep to,targeted
R429 T2650 T2651 amod distinct,regions
R430 T2651 T2649 pobj regions,to
R431 T2652 T2651 prep of,regions
R432 T2653 T2654 det the,PM
R433 T2654 T2652 pobj PM,of
R434 T2655 T2648 punct ;,routed
R435 T2656 T2648 prep for,routed
R436 T2657 T2656 pobj example,for
R437 T2658 T2648 punct ", ",routed
R438 T2659 T2648 nsubjpass AQP2,routed
R439 T2660 T2648 auxpass is,routed
R440 T2661 T2648 prep to,routed
R441 T2662 T2663 det the,membrane
R442 T2663 T2661 pobj membrane,to
R443 T2664 T2663 amod apical,membrane
R444 T2665 T2663 prep of,membrane
R445 T2666 T2665 pobj cells,of
R446 T2667 T2666 acl surrounding,cells
R447 T2668 T2669 det the,duct
R448 T2669 T2667 dobj duct,surrounding
R449 T2670 T2669 amod collecting,duct
R450 T2671 T2648 punct ", ",routed
R451 T2672 T2673 mark whereas,inserted
R452 T2673 T2648 advcl inserted,routed
R453 T2674 T2675 amod other,aquaporins
R454 T2675 T2673 nsubjpass aquaporins,inserted
R455 T2676 T2675 punct (,aquaporins
R456 T2677 T2675 appos AQP3,aquaporins
R457 T2678 T2677 cc or,AQP3
R458 T2679 T2677 conj 4,AQP3
R459 T2680 T2673 punct ),inserted
R460 T2681 T2673 auxpass are,inserted
R461 T2682 T2673 prep into,inserted
R462 T2683 T2684 det the,face
R463 T2684 T2682 pobj face,into
R464 T2685 T2684 amod basolateral,face
R465 T2686 T2648 punct .,routed
R466 T2688 T2689 prep Unlike,inserted
R467 T2690 T2691 det all,members
R468 T2691 T2688 pobj members,Unlike
R469 T2692 T2691 amod other,members
R470 T2693 T2691 compound family,members
R471 T2694 T2689 punct ", ",inserted
R472 T2695 T2689 nsubjpass AQP2,inserted
R473 T2696 T2689 auxpass is,inserted
R474 T2697 T2689 neg not,inserted
R475 T2698 T2689 advmod constitutively,inserted
R476 T2699 T2689 prep into,inserted
R477 T2700 T2701 det the,membrane
R478 T2701 T2699 pobj membrane,into
R479 T2702 T2701 compound plasma,membrane
R480 T2703 T2689 punct .,inserted
R481 T2705 T2706 prep Under,resides
R482 T2706 T2712 ccomp resides,translocates
R483 T2707 T2708 amod basal,conditions
R484 T2708 T2705 pobj conditions,Under
R485 T2709 T2706 punct ", ",resides
R486 T2710 T2711 det the,protein
R487 T2711 T2706 nsubj protein,resides
R488 T2713 T2706 prep in,resides
R489 T2714 T2715 amod subapical,vesicles
R490 T2715 T2713 pobj vesicles,in
R491 T2716 T2715 amod intracellular,vesicles
R492 T2717 T2712 punct ;,translocates
R493 T2718 T2712 advmod however,translocates
R494 T2719 T2712 punct ", ",translocates
R495 T2720 T2712 prep under,translocates
R496 T2721 T2720 pobj conditions,under
R497 T2722 T2721 acl requiring,conditions
R498 T2723 T2724 compound water,retention
R499 T2724 T2722 dobj retention,requiring
R500 T2725 T2712 nsubj AQP2,translocates
R501 T2726 T2712 prep to,translocates
R502 T2727 T2728 det the,membrane
R503 T2728 T2726 pobj membrane,to
R504 T2729 T2728 amod apical,membrane
R505 T2730 T2712 punct ", ",translocates
R506 T2731 T2712 advcl permitting,translocates
R507 T2732 T2733 compound water,reabsorption
R508 T2733 T2731 dobj reabsorption,permitting
R509 T2734 T2735 punct [,8
R510 T2735 T2712 parataxis 8,translocates
R511 T2736 T2735 nummod 7,8
R512 T2737 T2735 punct ",",8
R513 T2738 T2735 punct ],8
R514 T2739 T2712 punct .,translocates
R515 T2741 T2742 mark For,occur
R516 T2742 T2746 advcl occur,binds
R517 T2743 T2744 det this,process
R518 T2744 T2742 nsubj process,occur
R519 T2745 T2742 aux to,occur
R520 T2747 T2746 punct ", ",binds
R521 T2748 T2746 nsubj AVP,binds
R522 T2749 T2750 poss its,receptor
R523 T2750 T2746 dobj receptor,binds
R524 T2751 T2750 punct ", ",receptor
R525 T2752 T2750 appos AVPR2,receptor
R526 T2753 T2746 punct ", ",binds
R527 T2754 T2746 prep on,binds
R528 T2755 T2756 det the,face
R529 T2756 T2754 pobj face,on
R530 T2757 T2756 amod basolateral,face
R531 T2758 T2756 prep of,face
R532 T2759 T2760 det the,cells
R533 T2760 T2758 pobj cells,of
R534 T2761 T2762 amod collecting,duct
R535 T2762 T2760 compound duct,cells
R536 T2763 T2746 punct ", ",binds
R537 T2764 T2746 advcl leading,binds
R538 T2765 T2764 prep to,leading
R539 T2766 T2767 det a,rise
R540 T2767 T2765 pobj rise,to
R541 T2768 T2767 prep in,rise
R542 T2769 T2770 amod intracellular,cAMP
R543 T2770 T2768 pobj cAMP,in
R544 T2771 T2764 punct ", ",leading
R545 T2772 T2773 advmod ultimately,resulting
R546 T2773 T2764 advcl resulting,leading
R547 T2774 T2773 prep in,resulting
R548 T2775 T2774 pobj phosphorylation,in
R549 T2776 T2775 prep of,phosphorylation
R550 T2777 T2776 pobj AQP2,of
R551 T2778 T2775 prep at,phosphorylation
R552 T2779 T2778 pobj serine,at
R553 T2780 T2779 nummod 256,serine
R554 T2781 T2775 prep by,phosphorylation
R555 T2782 T2783 npadvmod cAMP,dependent
R556 T2783 T2785 amod dependent,kinase
R557 T2784 T2783 punct -,dependent
R558 T2785 T2781 pobj kinase,by
R559 T2786 T2785 compound protein,kinase
R560 T2787 T2788 punct [,9
R561 T2788 T2775 parataxis 9,phosphorylation
R562 T2789 T2788 punct ],9
R563 T2790 T2775 cc and,phosphorylation
R564 T2791 T2792 poss its,redistribution
R565 T2792 T2775 conj redistribution,phosphorylation
R566 T2793 T2792 prep to,redistribution
R567 T2794 T2795 det the,membrane
R568 T2795 T2793 pobj membrane,to
R569 T2796 T2795 compound plasma,membrane
R570 T2797 T2746 punct .,binds
R571 T2799 T2800 det The,importance
R572 T2800 T2801 nsubjpass importance,highlighted
R573 T2802 T2800 prep of,importance
R574 T2803 T2804 compound AQP2,redistribution
R575 T2804 T2802 pobj redistribution,of
R576 T2805 T2801 aux has,highlighted
R577 T2806 T2801 auxpass been,highlighted
R578 T2807 T2801 agent by,highlighted
R579 T2808 T2809 amod functional,characterization
R580 T2809 T2807 pobj characterization,by
R581 T2810 T2809 prep of,characterization
R582 T2811 T2812 compound Aqp2,mutations
R583 T2812 T2810 pobj mutations,of
R584 T2813 T2801 advcl resulting,highlighted
R585 T2814 T2813 prep in,resulting
R586 T2815 T2816 amod severe,NDI
R587 T2816 T2814 pobj NDI,in
R588 T2817 T2813 prep in,resulting
R589 T2818 T2817 pobj humans,in
R590 T2819 T2820 punct [,10
R591 T2820 T2801 parataxis 10,highlighted
R592 T2821 T2820 nummod 3,10
R593 T2822 T2820 punct ",",10
R594 T2823 T2820 punct ],10
R595 T2824 T2801 punct .,highlighted
R596 T2826 T2827 amod Recessive,mutations
R597 T2827 T2829 nsubjpass mutations,thought
R598 T2828 T2827 compound Aqp2,mutations
R599 T2830 T2829 auxpass are,thought
R600 T2831 T2829 advmod generally,thought
R601 T2832 T2833 aux to,produce
R602 T2833 T2829 xcomp produce,thought
R603 T2834 T2835 det an,pore
R604 T2835 T2833 dobj pore,produce
R605 T2836 T2837 advmod abnormally,localized
R606 T2837 T2835 amod localized,pore
R607 T2838 T2837 cc and,localized
R608 T2839 T2840 punct ", ",misfolded
R609 T2840 T2837 conj misfolded,localized
R610 T2841 T2840 prep in,misfolded
R611 T2842 T2843 amod most,instances
R612 T2843 T2841 pobj instances,in
R613 T2844 T2840 punct ", ",misfolded
R614 T2845 T2835 compound water,pore
R615 T2846 T2847 dep that,responds
R616 T2847 T2835 relcl responds,pore
R617 T2848 T2847 advmod abnormally,responds
R618 T2849 T2847 prep to,responds
R619 T2850 T2851 det an,increase
R620 T2851 T2849 pobj increase,to
R621 T2852 T2851 prep in,increase
R622 T2853 T2852 pobj cAMP,in
R623 T2854 T2855 punct [,11
R624 T2855 T2829 parataxis 11,thought
R625 T2856 T2855 nummod 6,11
R626 T2857 T2855 punct ",",11
R627 T2858 T2855 punct ],11
R628 T2859 T2829 punct .,thought
R629 T2861 T2862 advmod Furthermore,described
R630 T2863 T2862 punct ", ",described
R631 T2864 T2865 amod dominant,mutations
R632 T2865 T2862 nsubjpass mutations,described
R633 T2866 T2862 aux have,described
R634 T2867 T2862 auxpass been,described
R635 T2868 T2862 cc and,described
R636 T2869 T2862 conj found,described
R637 T2870 T2871 aux to,misroute
R638 T2871 T2869 xcomp misroute,found
R639 T2872 T2873 preconj both,mutant
R640 T2873 T2871 dobj mutant,misroute
R641 T2874 T2873 det the,mutant
R642 T2875 T2873 cc and,mutant
R643 T2876 T2877 det the,type
R644 T2877 T2880 compound type,protein
R645 T2878 T2877 amod wild,type
R646 T2879 T2877 punct -,type
R647 T2880 T2873 conj protein,mutant
R648 T2881 T2871 prep to,misroute
R649 T2882 T2883 det the,membrane
R650 T2883 T2881 pobj membrane,to
R651 T2884 T2883 amod basolateral,membrane
R652 T2885 T2886 punct [,12
R653 T2886 T2869 parataxis 12,found
R654 T2887 T2886 nummod 6,12
R655 T2888 T2886 punct ",",12
R656 T2889 T2886 punct ],12
R657 T2890 T2862 punct .,described
R658 T2892 T2893 amod Several,models
R659 T2893 T2895 nsubjpass models,generated
R660 T2894 T2893 compound mouse,models
R661 T2896 T2893 prep of,models
R662 T2897 T2898 compound diabetes,insipidus
R663 T2898 T2896 pobj insipidus,of
R664 T2899 T2895 aux have,generated
R665 T2900 T2895 auxpass been,generated
R666 T2901 T2902 punct [,13
R667 T2902 T2895 parataxis 13,generated
R668 T2903 T2904 punct –,17
R669 T2904 T2902 prep 17,13
R670 T2905 T2902 punct ],13
R671 T2906 T2895 punct .,generated
R672 T2908 T2909 prep In,generated
R673 T2910 T2911 det an,attempt
R674 T2911 T2908 pobj attempt,In
R675 T2912 T2913 aux to,recapitulate
R676 T2913 T2911 acl recapitulate,attempt
R677 T2914 T2915 amod human,NDI
R678 T2915 T2913 dobj NDI,recapitulate
R679 T2916 T2909 punct ", ",generated
R680 T2917 T2909 nsubjpass mice,generated
R681 T2918 T2909 aux have,generated
R682 T2919 T2909 auxpass been,generated
R683 T2920 T2909 prep with,generated
R684 T2921 T2920 pobj mutations,with
R685 T2922 T2921 prep in,mutations
R686 T2923 T2922 pobj Aqp2,in
R687 T2924 T2923 cc and,Aqp2
R688 T2925 T2923 conj Avpr2,Aqp2
R689 T2926 T2927 punct [,18
R690 T2927 T2909 parataxis 18,generated
R691 T2928 T2927 nummod 15,18
R692 T2929 T2927 punct ",",18
R693 T2930 T2927 punct ],18
R694 T2931 T2909 punct .,generated
R695 T2933 T2934 nsubj Yang,created
R696 T2935 T2933 cc and,Yang
R697 T2936 T2933 conj colleagues,Yang
R698 T2937 T2938 det a,mouse
R699 T2938 T2934 dobj mouse,created
R700 T2939 T2938 prep with,mouse
R701 T2940 T2941 det a,mutation
R702 T2941 T2939 pobj mutation,with
R703 T2942 T2941 nmod T126M,mutation
R704 T2943 T2941 amod knock,mutation
R705 T2944 T2943 punct -,knock
R706 T2945 T2943 prt in,knock
R707 T2946 T2941 prep in,mutation
R708 T2947 T2948 det the,gene
R709 T2948 T2946 pobj gene,in
R710 T2949 T2948 compound Aqp2,gene
R711 T2950 T2934 punct .,created
R712 T2952 T2953 advmod Unexpectedly,died
R713 T2954 T2953 punct ", ",died
R714 T2955 T2956 amod homozygous,mice
R715 T2956 T2953 nsubj mice,died
R716 T2957 T2956 compound mutant,mice
R717 T2958 T2953 prep within,died
R718 T2959 T2960 nummod 6,d
R719 T2960 T2958 pobj d,within
R720 T2961 T2960 prep after,d
R721 T2962 T2961 pobj birth,after
R722 T2963 T2953 punct .,died
R723 T2965 T2966 advmod Interestingly,die
R724 T2967 T2966 punct ", ",die
R725 T2968 T2969 npadvmod AVPR2,deficient
R726 T2969 T2971 amod deficient,pups
R727 T2970 T2969 punct -,deficient
R728 T2971 T2966 nsubj pups,die
R729 T2972 T2971 amod male,pups
R730 T2973 T2966 advmod also,die
R731 T2974 T2966 prep within,die
R732 T2975 T2976 det the,week
R733 T2976 T2974 pobj week,within
R734 T2977 T2976 amod first,week
R735 T2978 T2976 prep after,week
R736 T2979 T2978 pobj birth,after
R737 T2980 T2966 punct .,die
R738 T2982 T2983 advmod Together,suggest
R739 T2984 T2985 det these,models
R740 T2985 T2983 nsubj models,suggest
R741 T2986 T2987 mark that,be
R742 T2987 T2983 ccomp be,suggest
R743 T2988 T2989 det the,mouse
R744 T2989 T2987 nsubj mouse,be
R745 T3096 T3095 punct -,duct
R746 T2990 T2987 aux may,be
R747 T3097 T3084 punct ", ",adopts
R748 T2991 T2992 det a,organism
R749 T2992 T2987 attr organism,be
R750 T3098 T3084 cc and,adopts
R751 T2993 T2994 advmod highly,sensitive
R752 T2994 T2992 amod sensitive,organism
R753 T3099 T3084 conj was,adopts
R754 T2995 T2987 prep with,be
R755 T2996 T2995 pobj regard,with
R756 T3100 T3099 acomp resistant,was
R757 T2997 T2996 prep to,regard
R758 T2998 T2999 compound water,homeostasis
R759 T2999 T2997 pobj homeostasis,to
R760 T3000 T2987 punct ", ",be
R761 T3001 T2987 cc and,be
R762 T3101 T3100 prep to,resistant
R763 T3002 T2987 conj is,be
R764 T3003 T3002 acomp unable,is
R765 T3004 T3005 aux to,survive
R766 T3102 T3101 pobj translocation,to
R767 T3005 T3003 xcomp survive,unable
R768 T3006 T3005 prep with,survive
R769 T3007 T3006 pobj polyuria,with
R770 T3103 T3102 acl induced,translocation
R771 T3008 T2983 punct .,suggest
R772 T3010 T3011 prep In,identified
R773 T3104 T3103 agent by,induced
R774 T3012 T3013 det a,screen
R775 T3105 T3104 pobj desmopressin,by
R776 T3013 T3010 pobj screen,In
R777 T3014 T3015 advmod forward,genetic
R778 T3015 T3013 amod genetic,screen
R779 T3016 T3011 punct ", ",identified
R780 T3106 T3105 punct ", ",desmopressin
R781 T3017 T3018 det a,mouse
R782 T3018 T3011 nsubjpass mouse,identified
R783 T3107 T3108 det an,agonist
R784 T3019 T3018 prep with,mouse
R785 T3020 T3021 det an,mutation
R786 T3021 T3019 pobj mutation,with
R787 T3108 T3105 appos agonist,desmopressin
R788 T3109 T3108 prep of,agonist
R789 T3022 T3021 compound Aqp2,mutation
R790 T3023 T3011 auxpass was,identified
R791 T3024 T3011 punct .,identified
R792 T3026 T3027 det The,purpose
R793 T3110 T3109 pobj AVP,of
R794 T3027 T3028 nsubj purpose,was
R795 T3029 T3027 prep of,purpose
R796 T3030 T3031 det this,study
R797 T3111 T3082 punct .,concluded
R798 T3031 T3029 pobj study,of
R799 T3032 T3033 aux to,characterize
R800 T3033 T3028 xcomp characterize,was
R801 T3113 T3114 advmod In,vitro
R802 T3034 T3035 det this,model
R803 T3035 T3033 dobj model,characterize
R804 T3036 T3035 amod murine,model
R805 T3037 T3035 prep of,model
R806 T3114 T3115 amod vitro,studies
R807 T3038 T3039 amod recessive,DI
R808 T3039 T3037 pobj DI,of
R809 T3115 T3116 nsubj studies,demonstrated
R810 T3040 T3039 amod nephrogenic,DI
R811 T3041 T3028 punct .,was
R812 T3043 T3044 nsubj We,report
R813 T3045 T3044 advmod now,report
R814 T3117 T3115 acl using,studies
R815 T3046 T3047 det a,mutation
R816 T3047 T3044 dobj mutation,report
R817 T3048 T3047 amod novel,mutation
R818 T3049 T3047 compound F204V,mutation
R819 T3118 T3119 det the,line
R820 T3050 T3047 prep in,mutation
R821 T3051 T3052 det the,gene
R822 T3052 T3050 pobj gene,in
R823 T3119 T3117 dobj line,using
R824 T3053 T3052 compound Aqp2,gene
R825 T3054 T3044 punct .,report
R826 T3120 T3121 nmod Madin,Darby
R827 T3056 T3057 det This,allele
R828 T3057 T3058 nsubjpass allele,found
R829 T3121 T3123 nmod Darby,kidney
R830 T3059 T3057 prep of,allele
R831 T3060 T3059 pobj Aqp2,of
R832 T3122 T3121 punct -,Darby
R833 T3061 T3058 auxpass was,found
R834 T3062 T3063 aux to,cause
R835 T3063 T3058 xcomp cause,found
R836 T3123 T3119 nmod kidney,line
R837 T3064 T3065 det the,model
R838 T3065 T3068 nsubj model,survive
R839 T3124 T3123 amod canine,kidney
R840 T3066 T3065 amod first,model
R841 T3067 T3065 compound mouse,model
R842 T3125 T3123 punct (,kidney
R843 T3068 T3063 ccomp survive,cause
R844 T3069 T3065 prep of,model
R845 T3070 T3069 pobj NDI,of
R846 T3126 T3123 appos MDCK,kidney
R847 T3071 T3068 aux to,survive
R848 T3072 T3068 prep past,survive
R849 T3073 T3074 det the,week
R850 T3127 T3119 punct ),line
R851 T3074 T3072 pobj week,past
R852 T3075 T3074 amod first,week
R853 T3076 T3074 prep of,week
R854 T3128 T3119 compound cell,line
R855 T3129 T3130 det an,pattern
R856 T3130 T3116 dobj pattern,demonstrated
R857 T3077 T3076 pobj life,of
R858 T3078 T3058 punct .,found
R859 T3131 T3130 amod endoplasmic,pattern
R860 T3080 T3081 amod Molecular,analyses
R861 T3132 T3130 compound reticulum,pattern
R862 T3081 T3082 nsubj analyses,concluded
R863 T3083 T3084 mark that,adopts
R864 T3084 T3082 ccomp adopts,concluded
R865 T3085 T3086 compound mutant,AQP2
R866 T3086 T3084 nsubj AQP2,adopts
R867 T3133 T3130 prep for,pattern
R868 T3087 T3088 det a,localization
R869 T3088 T3084 dobj localization,adopts
R870 T3089 T3088 amod different,localization
R871 T3134 T3135 det the,protein
R872 T3090 T3088 amod subcellular,localization
R873 T3091 T3084 prep in,adopts
R874 T3092 T3093 amod renal,cells
R875 T3135 T3133 pobj protein,for
R876 T3093 T3091 pobj cells,in
R877 T3094 T3095 amod collecting,duct
R878 T3136 T3135 compound mutant,protein
R879 T3095 T3093 compound duct,cells
R880 T3137 T3130 punct ", ",pattern
R881 T3138 T3130 cc and,pattern
R882 T3139 T3140 amod apparent,resistance
R883 T3140 T3130 conj resistance,pattern
R884 T3141 T3140 prep to,resistance
R885 T3142 T3141 pobj translocation,to
R886 T3143 T3116 punct .,demonstrated
R887 T3145 T3146 det These,data
R888 T3146 T3147 nsubj data,prove
R889 T3148 T3147 advmod conclusively,prove
R890 T3149 T3150 mark that,is
R891 T3150 T3147 ccomp is,prove
R892 T3151 T3152 amod autosomal,NDI
R893 T3152 T3150 nsubj NDI,is
R894 T3153 T3152 amod recessive,NDI
R895 T3154 T3155 det a,consequence
R896 T3155 T3150 attr consequence,is
R897 T3156 T3155 prep of,consequence
R898 T3157 T3158 amod improper,routing
R899 T3158 T3156 pobj routing,of
R900 T3159 T3158 compound AQP2,routing
R901 T3160 T3158 prep in,routing
R902 T3161 T3162 det the,mammal
R903 T3162 T3160 pobj mammal,in
R904 T3163 T3162 amod intact,mammal
R905 T3164 T3147 punct .,prove

2_test

Id Subject Object Predicate Lexical cue
16121255-1303271-85587770 286-287 1303271 denotes 2
16121255-8140421-85587771 337-338 8140421 denotes 3
16121255-15340377-85587772 427-428 15340377 denotes 4
16121255-8429910-85587773 501-502 8429910 denotes 5
16121255-15340377-85587774 850-851 15340377 denotes 4
16121255-14662748-85587775 852-853 14662748 denotes 6
16121255-7573395-85587776 1421-1422 7573395 denotes 7
16121255-7532304-85587777 1423-1424 7532304 denotes 8
16121255-9169447-85587778 1676-1677 9169447 denotes 9
16121255-8140421-85587779 1869-1870 8140421 denotes 3
16121255-7524315-85587780 1871-1873 7524315 denotes 10
16121255-14662748-85587781 2052-2053 14662748 denotes 6
16121255-7537761-85587782 2054-2056 7537761 denotes 11
16121255-14662748-85587783 2204-2205 14662748 denotes 6
16121255-12787389-85587784 2206-2208 12787389 denotes 12
16121255-10737773-85587785 2275-2277 10737773 denotes 13
16121255-9468475-85587785 2275-2277 9468475 denotes 13
16121255-11104789-85587785 2275-2277 11104789 denotes 13
16121255-11035042-85587785 2275-2277 11035042 denotes 13
16121255-9916798-85587785 2275-2277 9916798 denotes 13
16121255-11104789-85587786 2383-2385 11104789 denotes 15
16121255-11035038-85587787 2386-2388 11035038 denotes 18
T75474 286-287 1303271 denotes 2
T23969 337-338 8140421 denotes 3
T80160 427-428 15340377 denotes 4
T58437 501-502 8429910 denotes 5
T25086 850-851 15340377 denotes 4
T18302 852-853 14662748 denotes 6
T9860 1421-1422 7573395 denotes 7
T15323 1423-1424 7532304 denotes 8
T75916 1676-1677 9169447 denotes 9
T18141 1869-1870 8140421 denotes 3
T51778 1871-1873 7524315 denotes 10
T58588 2052-2053 14662748 denotes 6
T19533 2054-2056 7537761 denotes 11
T63695 2204-2205 14662748 denotes 6
T49393 2206-2208 12787389 denotes 12
T73785 2275-2277 10737773 denotes 13
T69562 2275-2277 9468475 denotes 13
T43226 2275-2277 11104789 denotes 13
T51402 2275-2277 11035042 denotes 13
T85688 2275-2277 9916798 denotes 13
T21889 2383-2385 11104789 denotes 15
T948 2386-2388 11035038 denotes 18