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PMC:1189073 / 26874-28899 JSONTXT

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craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T13984 38-42 PR_EXT:000004182 denotes Aqp2
T13985 59-63 SO_EXT:0000704 denotes gene
T13986 88-92 NCBITaxon:10088 denotes mice
T13987 119-123 PR_EXT:000004182 denotes AQP2
T13988 154-159 CHEBI:15377 denotes water
T13989 154-172 GO:0006833 denotes water transporting
T13990 199-202 CHEBI_PR_EXT:arginine_vasopressin denotes AVP
T13991 228-233 CHEBI:15377 denotes water
T13992 269-273 PR_EXT:000004182 denotes AQP2
T13993 294-300 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T13994 301-308 NCBITaxon:33208 denotes animals
T13995 325-333 GO_EXT:reaction_or_response denotes response
T13996 337-342 CHEBI:4450 denotes dDAVP
T13997 353-358 CHEBI:4450 denotes dDAVP
T13998 370-375 UBERON:0001088 denotes urine
T13999 424-430 UBERON:0002113 denotes kidney
T14000 442-446 PR_EXT:000004182 denotes AQP2
T14001 474-483 GO_EXT:biological_routing_or_transport denotes transport
T14002 484-489 CHEBI:15377 denotes water
T14003 511-519 GO_PATO_EXT:biological_localization_process_or_quality denotes localize
T14004 527-533 GO:0045177 denotes apical
T14005 534-538 CL_GO_EXT:cell denotes cell
T14006 534-546 GO:0009986 denotes cell surface
T14007 553-558 CHEBI:4450 denotes dDAVP
T14008 596-600 PR_EXT:000004182 denotes AQP2
T14009 658-664 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T14010 665-672 CHEBI_PR_EXT:protein denotes protein
T14011 691-695 CL_GO_EXT:cell denotes cell
T14012 691-703 GO:0009986 denotes cell surface
T14013 709-716 GO:0009986 denotes surface
T14014 717-730 MOP:0000093 denotes biotinylation
T14015 771-777 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T14016 778-785 CHEBI_PR_EXT:protein denotes protein
T14017 798-805 GO:0009986 denotes surface
T14018 897-904 CHEBI_PR_EXT:protein denotes protein
T14019 983-989 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T14020 990-997 CHEBI_PR_EXT:protein denotes protein
T14021 1023-1025 GO:0005783 denotes ER
T14022 1072-1081 SO_EXT:wild_type_entity_or_quality denotes wild-type
T14023 1083-1089 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T14024 1090-1097 CHEBI_PR_EXT:protein denotes protein
T14025 1122-1129 CHEBI:37684 denotes mannose
T14026 1136-1148 GO_MOP_EXT:glycosylation denotes glycosylated
T14027 1183-1195 GO_MOP_EXT:glycosylation denotes glycosylated
T14028 1217-1229 GO_MOP_EXT:glycosylation denotes glycosylated
T14029 1300-1307 CHEBI_PR_EXT:protein denotes protein
T14030 1346-1352 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T14031 1353-1360 CHEBI_PR_EXT:protein denotes protein
T14032 1364-1375 GO_EXT:biological_routing_or_transport denotes transported
T14033 1387-1389 GO:0005783 denotes ER
T14034 1430-1442 GO_PATO_EXT:biological_localization_process_or_quality denotes localization
T14035 1446-1450 PR_EXT:000004182 denotes AQP2
T14036 1466-1468 GO:0005783 denotes ER
T14037 1469-1476 CHEBI_PR_EXT:protein denotes protein
T14038 1477-1485 PR_EXT:000005005 denotes calnexin
T14039 1489-1500 GO:0009294 denotes transfected
T14040 1506-1511 CL_GO_EXT:cell denotes cells
T14041 1542-1548 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T14042 1549-1556 CHEBI_PR_EXT:protein denotes protein
T14043 1575-1577 GO:0005783 denotes ER
T14044 1609-1611 GO:0005783 denotes ER
T14045 1624-1632 GO_EXT:reaction_or_response denotes response
T14046 1636-1641 CHEBI:4450 denotes dDAVP
T14047 1674-1686 GO_MOP_EXT:glycosylation denotes glycosylated
T14048 1687-1694 CHEBI_PR_EXT:protein denotes protein
T14049 1698-1704 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T14050 1705-1712 NCBITaxon:33208 denotes animals
T14051 1722-1734 _FRAGMENT denotes transport of
T14052 1756-1763 GO:0015031 denotes protein
T14053 1749-1755 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T14054 1756-1763 CHEBI_PR_EXT:protein denotes protein
T14055 1775-1777 GO:0005783 denotes ER
T14056 1786-1791 CL_GO_EXT:cell denotes cells
T14057 1832-1836 PR_EXT:000004182 denotes AQP2
T14058 1846-1853 GO:0006457 denotes folding
T14059 1902-1907 CHEBI:15377 denotes water
T14060 1902-1920 GO:0006833 denotes water transporting
T14061 2000-2006 GO_EXT:biological_growth_entity_or_process denotes growth
T14062 2010-2016 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T14063 2017-2024 NCBITaxon:33208 denotes animals
R3377 T14052 T14051 _lexicallyChainedTo protein,transport of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T13840 38-42 PR:000004182 denotes Aqp2
T13841 59-63 SO:0000704 denotes gene
T13842 88-92 NCBITaxon:10088 denotes mice
T13843 119-123 PR:000004182 denotes AQP2
T13844 154-159 CHEBI:15377 denotes water
T13845 154-172 GO:0006833 denotes water transporting
T13846 228-233 CHEBI:15377 denotes water
T13847 269-273 PR:000004182 denotes AQP2
T13848 301-308 NCBITaxon:33208 denotes animals
T13849 337-342 CHEBI:4450 denotes dDAVP
T13850 353-358 CHEBI:4450 denotes dDAVP
T13851 370-375 UBERON:0001088 denotes urine
T13852 424-430 UBERON:0002113 denotes kidney
T13853 442-446 PR:000004182 denotes AQP2
T13854 484-489 CHEBI:15377 denotes water
T13855 527-533 GO:0045177 denotes apical
T13856 534-546 GO:0009986 denotes cell surface
T13857 553-558 CHEBI:4450 denotes dDAVP
T13858 596-600 PR:000004182 denotes AQP2
T13859 691-703 GO:0009986 denotes cell surface
T13860 709-716 GO:0009986 denotes surface
T13861 717-730 MOP:0000093 denotes biotinylation
T13862 798-805 GO:0009986 denotes surface
T13863 1023-1025 GO:0005783 denotes ER
T13864 1122-1129 CHEBI:37684 denotes mannose
T13865 1387-1389 GO:0005783 denotes ER
T13866 1446-1450 PR:000004182 denotes AQP2
T13867 1466-1468 GO:0005783 denotes ER
T13868 1477-1485 PR:000005005 denotes calnexin
T13869 1489-1500 GO:0009294 denotes transfected
T13870 1575-1577 GO:0005783 denotes ER
T13871 1609-1611 GO:0005783 denotes ER
T13872 1636-1641 CHEBI:4450 denotes dDAVP
T13873 1705-1712 NCBITaxon:33208 denotes animals
T13874 1722-1734 _FRAGMENT denotes transport of
T13875 1756-1763 GO:0015031 denotes protein
T13876 1775-1777 GO:0005783 denotes ER
T13877 1832-1836 PR:000004182 denotes AQP2
T13878 1846-1853 GO:0006457 denotes folding
T13879 1902-1907 CHEBI:15377 denotes water
T13880 1902-1920 GO:0006833 denotes water transporting
T13881 2017-2024 NCBITaxon:33208 denotes animals
R3376 T13875 T13874 _lexicallyChainedTo protein,transport of

craft-sa-dev

Id Subject Object Predicate Lexical cue
T14400 0-3 DT denotes The
T14401 16-18 NN denotes in
T14402 4-9 NN denotes T126M
T14403 10-15 NN denotes knock
T14404 15-16 HYPH denotes -
T14405 27-32 VBZ denotes shows
T14406 19-26 RB denotes clearly
T14407 33-37 IN denotes that
T14408 43-45 VBZ denotes is
T14409 38-42 NN denotes Aqp2
T14410 46-48 DT denotes an
T14411 59-63 NN denotes gene
T14412 49-58 JJ denotes essential
T14413 64-65 -LRB- denotes [
T14414 65-67 CD denotes 18
T14415 67-68 -RRB- denotes ]
T14416 68-69 . denotes .
T14417 69-247 sentence denotes The fact that our mice survive shows either that AQP2-F204V possesses some residual water transporting ability or that there are AVP-independent pathways for water reabsorption.
T14418 70-73 DT denotes The
T14419 74-78 NN denotes fact
T14420 101-106 VBZ denotes shows
T14421 79-83 IN denotes that
T14422 93-100 VBP denotes survive
T14423 84-87 PRP$ denotes our
T14424 88-92 NNS denotes mice
T14425 107-113 CC denotes either
T14426 130-139 VBZ denotes possesses
T14427 114-118 IN denotes that
T14428 119-123 NN denotes AQP2
T14429 124-129 NN denotes F204V
T14430 123-124 HYPH denotes -
T14431 140-144 DT denotes some
T14432 173-180 NN denotes ability
T14433 145-153 JJ denotes residual
T14434 154-159 NN denotes water
T14435 160-172 VBG denotes transporting
T14436 181-183 CC denotes or
T14437 184-188 IN denotes that
T14438 195-198 VBP denotes are
T14439 189-194 EX denotes there
T14440 199-202 NN denotes AVP
T14441 203-214 JJ denotes independent
T14442 202-203 HYPH denotes -
T14443 215-223 NNS denotes pathways
T14444 224-227 IN denotes for
T14445 228-233 NN denotes water
T14446 234-246 NN denotes reabsorption
T14447 246-247 . denotes .
T14448 247-405 sentence denotes Residual activity of AQP2-F204V is likely, as mutant animals show some small response to dDAVP, although dDAVP-stimulated urine osmolality remains quite low.
T14449 248-256 JJ denotes Residual
T14450 257-265 NN denotes activity
T14451 280-282 VBZ denotes is
T14452 266-268 IN denotes of
T14453 269-273 NN denotes AQP2
T14454 274-279 NN denotes F204V
T14455 273-274 HYPH denotes -
T14456 283-289 JJ denotes likely
T14457 289-291 , denotes ,
T14458 291-293 IN denotes as
T14459 309-313 VBP denotes show
T14460 294-300 NN denotes mutant
T14461 301-308 NNS denotes animals
T14462 314-318 DT denotes some
T14463 325-333 NN denotes response
T14464 319-324 JJ denotes small
T14465 334-336 IN denotes to
T14466 337-342 NN denotes dDAVP
T14467 342-344 , denotes ,
T14468 344-352 IN denotes although
T14469 387-394 VBZ denotes remains
T14470 353-358 NN denotes dDAVP
T14471 359-369 VBN denotes stimulated
T14472 358-359 HYPH denotes -
T14473 376-386 NN denotes osmolality
T14474 370-375 NN denotes urine
T14475 395-400 RB denotes quite
T14476 401-404 JJ denotes low
T14477 404-405 . denotes .
T14478 405-569 sentence denotes Immunostaining of kidney shows that AQP2-F204V does not efficiently transport water, because it fails to localize to the apical cell surface after dDAVP treatment.
T14479 406-420 NN denotes Immunostaining
T14480 431-436 VBZ denotes shows
T14481 421-423 IN denotes of
T14482 424-430 NN denotes kidney
T14483 437-441 IN denotes that
T14484 474-483 VB denotes transport
T14485 442-446 NN denotes AQP2
T14486 447-452 NN denotes F204V
T14487 446-447 HYPH denotes -
T14488 453-457 VBZ denotes does
T14489 458-461 RB denotes not
T14490 462-473 RB denotes efficiently
T14491 484-489 NN denotes water
T14492 489-491 , denotes ,
T14493 491-498 IN denotes because
T14494 502-507 VBZ denotes fails
T14495 499-501 PRP denotes it
T14496 508-510 TO denotes to
T14497 511-519 VB denotes localize
T14498 520-522 IN denotes to
T14499 523-526 DT denotes the
T14500 539-546 NN denotes surface
T14501 527-533 JJ denotes apical
T14502 534-538 NN denotes cell
T14503 547-552 IN denotes after
T14504 553-558 NN denotes dDAVP
T14505 559-568 NN denotes treatment
T14506 568-569 . denotes .
T14507 569-704 sentence denotes Some residual activity of AQP2 would imply that some small, undetectable portion of the mutant protein is getting to the cell surface.
T14508 570-574 DT denotes Some
T14509 584-592 NN denotes activity
T14510 575-583 JJ denotes residual
T14511 607-612 VB denotes imply
T14512 593-595 IN denotes of
T14513 596-600 NN denotes AQP2
T14514 601-606 MD denotes would
T14515 613-617 IN denotes that
T14516 676-683 VBG denotes getting
T14517 618-622 DT denotes some
T14518 643-650 NN denotes portion
T14519 623-628 JJ denotes small
T14520 628-630 , denotes ,
T14521 630-642 JJ denotes undetectable
T14522 651-653 IN denotes of
T14523 654-657 DT denotes the
T14524 665-672 NN denotes protein
T14525 658-664 NN denotes mutant
T14526 673-675 VBZ denotes is
T14527 684-686 IN denotes to
T14528 687-690 DT denotes the
T14529 696-703 NN denotes surface
T14530 691-695 NN denotes cell
T14531 703-704 . denotes .
T14532 704-867 sentence denotes The surface biotinylation experiment (Figure 5D) suggests that no mutant protein gets to the surface, but this does not necessarily reflect the situation in vivo.
T14533 705-708 DT denotes The
T14534 731-741 NN denotes experiment
T14535 709-716 NN denotes surface
T14536 717-730 NN denotes biotinylation
T14537 754-762 VBZ denotes suggests
T14538 742-743 -LRB- denotes (
T14539 743-749 NN denotes Figure
T14540 750-752 CD denotes 5D
T14541 752-753 -RRB- denotes )
T14542 763-767 IN denotes that
T14543 786-790 VBZ denotes gets
T14544 768-770 DT denotes no
T14545 778-785 NN denotes protein
T14546 771-777 NN denotes mutant
T14547 791-793 IN denotes to
T14548 794-797 DT denotes the
T14549 798-805 NN denotes surface
T14550 805-807 , denotes ,
T14551 807-810 CC denotes but
T14552 811-815 DT denotes this
T14553 837-844 VB denotes reflect
T14554 816-820 VBZ denotes does
T14555 821-824 RB denotes not
T14556 825-836 RB denotes necessarily
T14557 845-848 DT denotes the
T14558 849-858 NN denotes situation
T14559 859-861 FW denotes in
T14560 862-866 FW denotes vivo
T14561 866-867 . denotes .
T14562 867-1059 sentence denotes While this small fraction of protein may not be detectable by immunofluorescence, Western blotting shows that some mutant protein does progress beyond the ER (35–45 kDa species in Figure 3A).
T14563 868-873 IN denotes While
T14564 913-915 VB denotes be
T14565 874-878 DT denotes this
T14566 885-893 NN denotes fraction
T14567 879-884 JJ denotes small
T14568 894-896 IN denotes of
T14569 897-904 NN denotes protein
T14570 905-908 MD denotes may
T14571 909-912 RB denotes not
T14572 967-972 VBZ denotes shows
T14573 916-926 JJ denotes detectable
T14574 927-929 IN denotes by
T14575 930-948 NN denotes immunofluorescence
T14576 948-950 , denotes ,
T14577 950-957 NNP denotes Western
T14578 958-966 NN denotes blotting
T14579 973-977 IN denotes that
T14580 1003-1011 VB denotes progress
T14581 978-982 DT denotes some
T14582 990-997 NN denotes protein
T14583 983-989 NN denotes mutant
T14584 998-1002 VBZ denotes does
T14585 1012-1018 IN denotes beyond
T14586 1019-1022 DT denotes the
T14587 1023-1025 NN denotes ER
T14588 1026-1027 -LRB- denotes (
T14589 1037-1044 NNS denotes species
T14590 1027-1029 CD denotes 35
T14591 1030-1032 CD denotes 45
T14592 1029-1030 SYM denotes –
T14593 1033-1036 NN denotes kDa
T14594 1045-1047 IN denotes in
T14595 1048-1054 NN denotes Figure
T14596 1055-1057 CD denotes 3A
T14597 1057-1058 -RRB- denotes )
T14598 1058-1059 . denotes .
T14599 1059-1248 sentence denotes Compared to wild-type, mutant protein is enriched in the high-mannose, core-glycosylated form (31 kDa) and deficient in nonglycosylated (29 kDa) and complex glycosylated (35–45 kDa) forms.
T14600 1060-1068 VBN denotes Compared
T14601 1098-1100 VBZ denotes is
T14602 1069-1071 IN denotes to
T14603 1072-1076 JJ denotes wild
T14604 1077-1081 NN denotes type
T14605 1076-1077 HYPH denotes -
T14606 1081-1083 , denotes ,
T14607 1083-1089 NN denotes mutant
T14608 1090-1097 NN denotes protein
T14609 1101-1109 VBN denotes enriched
T14610 1110-1112 IN denotes in
T14611 1113-1116 DT denotes the
T14612 1149-1153 NN denotes form
T14613 1117-1121 JJ denotes high
T14614 1122-1129 NN denotes mannose
T14615 1121-1122 HYPH denotes -
T14616 1129-1131 , denotes ,
T14617 1131-1135 NN denotes core
T14618 1136-1148 VBN denotes glycosylated
T14619 1135-1136 HYPH denotes -
T14620 1154-1155 -LRB- denotes (
T14621 1158-1161 NN denotes kDa
T14622 1155-1157 CD denotes 31
T14623 1161-1162 -RRB- denotes )
T14624 1163-1166 CC denotes and
T14625 1167-1176 JJ denotes deficient
T14626 1177-1179 IN denotes in
T14627 1180-1195 JJ denotes nonglycosylated
T14628 1242-1247 NNS denotes forms
T14629 1196-1197 -LRB- denotes (
T14630 1200-1203 NN denotes kDa
T14631 1197-1199 CD denotes 29
T14632 1203-1204 -RRB- denotes )
T14633 1205-1208 CC denotes and
T14634 1209-1216 JJ denotes complex
T14635 1217-1229 JJ denotes glycosylated
T14636 1230-1231 -LRB- denotes (
T14637 1237-1240 NN denotes kDa
T14638 1231-1233 CD denotes 35
T14639 1234-1236 CD denotes 45
T14640 1233-1234 SYM denotes –
T14641 1240-1241 -RRB- denotes )
T14642 1247-1248 . denotes .
T14643 1248-1427 sentence denotes The presence of a reduced but detectable amount of protein in the 35–45 kDa range indicates that mutant protein is transported out of the ER, but with greatly reduced efficiency.
T14644 1249-1252 DT denotes The
T14645 1253-1261 NN denotes presence
T14646 1331-1340 VBZ denotes indicates
T14647 1262-1264 IN denotes of
T14648 1265-1266 DT denotes a
T14649 1290-1296 NN denotes amount
T14650 1267-1274 VBN denotes reduced
T14651 1275-1278 CC denotes but
T14652 1279-1289 JJ denotes detectable
T14653 1297-1299 IN denotes of
T14654 1300-1307 NN denotes protein
T14655 1308-1310 IN denotes in
T14656 1311-1314 DT denotes the
T14657 1325-1330 NN denotes range
T14658 1315-1317 CD denotes 35
T14659 1318-1320 CD denotes 45
T14660 1317-1318 SYM denotes –
T14661 1321-1324 NN denotes kDa
T14662 1341-1345 IN denotes that
T14663 1364-1375 VBN denotes transported
T14664 1346-1352 NN denotes mutant
T14665 1353-1360 NN denotes protein
T14666 1361-1363 VBZ denotes is
T14667 1376-1379 IN denotes out
T14668 1380-1382 IN denotes of
T14669 1383-1386 DT denotes the
T14670 1387-1389 NN denotes ER
T14671 1389-1391 , denotes ,
T14672 1391-1394 CC denotes but
T14673 1395-1399 IN denotes with
T14674 1400-1407 RB denotes greatly
T14675 1408-1415 VBN denotes reduced
T14676 1416-1426 NN denotes efficiency
T14677 1426-1427 . denotes .
T14678 1427-1612 sentence denotes Colocalization of AQP2-F204V with the ER protein calnexin in transfected MDCK cells shows that, while most of the mutant protein is trapped in the ER, some does progress beyond the ER.
T14679 1428-1442 NN denotes Colocalization
T14680 1512-1517 VBZ denotes shows
T14681 1443-1445 IN denotes of
T14682 1446-1450 NN denotes AQP2
T14683 1451-1456 NN denotes F204V
T14684 1450-1451 HYPH denotes -
T14685 1457-1461 IN denotes with
T14686 1462-1465 DT denotes the
T14687 1469-1476 NN denotes protein
T14688 1466-1468 NN denotes ER
T14689 1477-1485 NN denotes calnexin
T14690 1486-1488 IN denotes in
T14691 1489-1500 VBN denotes transfected
T14692 1506-1511 NNS denotes cells
T14693 1501-1505 NN denotes MDCK
T14694 1518-1522 IN denotes that
T14695 1589-1597 VB denotes progress
T14696 1522-1524 , denotes ,
T14697 1524-1529 IN denotes while
T14698 1560-1567 VBN denotes trapped
T14699 1530-1534 JJS denotes most
T14700 1535-1537 IN denotes of
T14701 1538-1541 DT denotes the
T14702 1549-1556 NN denotes protein
T14703 1542-1548 NN denotes mutant
T14704 1557-1559 VBZ denotes is
T14705 1568-1570 IN denotes in
T14706 1571-1574 DT denotes the
T14707 1575-1577 NN denotes ER
T14708 1577-1579 , denotes ,
T14709 1579-1583 DT denotes some
T14710 1584-1588 VBZ denotes does
T14711 1598-1604 IN denotes beyond
T14712 1605-1608 DT denotes the
T14713 1609-1611 NN denotes ER
T14714 1611-1612 . denotes .
T14715 1612-1930 sentence denotes Diminished response to dDAVP, diminished abundance of mature glycosylated protein in mutant animals, and the transport of a fraction of mutant protein beyond the ER in MDCK cells are all consistent with the notion that AQP2-F204V misfolding is limited and that it may retain some residual water transporting activity.
T14716 1613-1623 VBN denotes Diminished
T14717 1624-1632 NN denotes response
T14718 1792-1795 VBP denotes are
T14719 1633-1635 IN denotes to
T14720 1636-1641 NN denotes dDAVP
T14721 1641-1643 , denotes ,
T14722 1643-1653 VBN denotes diminished
T14723 1654-1663 NN denotes abundance
T14724 1664-1666 IN denotes of
T14725 1667-1673 JJ denotes mature
T14726 1687-1694 NN denotes protein
T14727 1674-1686 VBN denotes glycosylated
T14728 1695-1697 IN denotes in
T14729 1698-1704 NN denotes mutant
T14730 1705-1712 NNS denotes animals
T14731 1712-1714 , denotes ,
T14732 1714-1717 CC denotes and
T14733 1718-1721 DT denotes the
T14734 1722-1731 NN denotes transport
T14735 1732-1734 IN denotes of
T14736 1735-1736 DT denotes a
T14737 1737-1745 NN denotes fraction
T14738 1746-1748 IN denotes of
T14739 1749-1755 NN denotes mutant
T14740 1756-1763 NN denotes protein
T14741 1764-1770 IN denotes beyond
T14742 1771-1774 DT denotes the
T14743 1775-1777 NN denotes ER
T14744 1778-1780 IN denotes in
T14745 1781-1785 NN denotes MDCK
T14746 1786-1791 NNS denotes cells
T14747 1796-1799 RB denotes all
T14748 1800-1810 JJ denotes consistent
T14749 1811-1815 IN denotes with
T14750 1816-1819 DT denotes the
T14751 1820-1826 NN denotes notion
T14752 1827-1831 IN denotes that
T14753 1854-1856 VBZ denotes is
T14754 1832-1836 NN denotes AQP2
T14755 1837-1842 NN denotes F204V
T14756 1836-1837 HYPH denotes -
T14757 1843-1853 NN denotes misfolding
T14758 1857-1864 JJ denotes limited
T14759 1865-1868 CC denotes and
T14760 1869-1873 IN denotes that
T14761 1881-1887 VB denotes retain
T14762 1874-1876 PRP denotes it
T14763 1877-1880 MD denotes may
T14764 1888-1892 DT denotes some
T14765 1921-1929 NN denotes activity
T14766 1893-1901 JJ denotes residual
T14767 1902-1907 NN denotes water
T14768 1908-1920 VBG denotes transporting
T14769 1929-1930 . denotes .
T14770 1930-2025 sentence denotes Evidently this residual activity is sufficient for the viability and growth of mutant animals.
T14771 1931-1940 RB denotes Evidently
T14772 1964-1966 VBZ denotes is
T14773 1941-1945 DT denotes this
T14774 1955-1963 NN denotes activity
T14775 1946-1954 JJ denotes residual
T14776 1967-1977 JJ denotes sufficient
T14777 1978-1981 IN denotes for
T14778 1982-1985 DT denotes the
T14779 1986-1995 NN denotes viability
T14780 1996-1999 CC denotes and
T14781 2000-2006 NN denotes growth
T14782 2007-2009 IN denotes of
T14783 2010-2016 NN denotes mutant
T14784 2017-2024 NNS denotes animals
T14785 2024-2025 . denotes .
R3586 T14400 T14401 det The,in
R3587 T14401 T14405 nsubj in,shows
R3588 T14402 T14401 compound T126M,in
R3589 T14403 T14401 compound knock,in
R3590 T14404 T14401 punct -,in
R3591 T14406 T14405 advmod clearly,shows
R3592 T14407 T14408 mark that,is
R3593 T14408 T14405 ccomp is,shows
R3594 T14409 T14408 nsubj Aqp2,is
R3595 T14410 T14411 det an,gene
R3596 T14411 T14408 attr gene,is
R3597 T14412 T14411 amod essential,gene
R3598 T14413 T14414 punct [,18
R3599 T14414 T14405 parataxis 18,shows
R3600 T14415 T14414 punct ],18
R3601 T14416 T14405 punct .,shows
R3602 T14418 T14419 det The,fact
R3603 T14419 T14420 nsubj fact,shows
R3604 T14421 T14422 mark that,survive
R3605 T14422 T14419 acl survive,fact
R3606 T14423 T14424 poss our,mice
R3607 T14424 T14422 nsubj mice,survive
R3608 T14425 T14426 preconj either,possesses
R3609 T14426 T14420 advcl possesses,shows
R3610 T14427 T14426 mark that,possesses
R3611 T14428 T14429 compound AQP2,F204V
R3612 T14429 T14426 nsubj F204V,possesses
R3613 T14430 T14429 punct -,F204V
R3614 T14431 T14432 det some,ability
R3615 T14432 T14426 dobj ability,possesses
R3616 T14433 T14432 amod residual,ability
R3617 T14434 T14435 npadvmod water,transporting
R3618 T14435 T14432 amod transporting,ability
R3619 T14436 T14426 cc or,possesses
R3620 T14437 T14438 mark that,are
R3621 T14438 T14426 conj are,possesses
R3622 T14439 T14438 expl there,are
R3623 T14440 T14441 npadvmod AVP,independent
R3624 T14441 T14443 amod independent,pathways
R3625 T14442 T14441 punct -,independent
R3626 T14443 T14438 attr pathways,are
R3627 T14444 T14443 prep for,pathways
R3628 T14445 T14446 compound water,reabsorption
R3629 T14446 T14444 pobj reabsorption,for
R3630 T14447 T14420 punct .,shows
R3631 T14449 T14450 amod Residual,activity
R3632 T14450 T14451 nsubj activity,is
R3633 T14452 T14450 prep of,activity
R3634 T14453 T14454 compound AQP2,F204V
R3635 T14454 T14452 pobj F204V,of
R3636 T14455 T14454 punct -,F204V
R3637 T14456 T14451 acomp likely,is
R3638 T14457 T14451 punct ", ",is
R3639 T14458 T14459 mark as,show
R3640 T14459 T14451 advcl show,is
R3641 T14460 T14461 compound mutant,animals
R3642 T14461 T14459 nsubj animals,show
R3643 T14462 T14463 det some,response
R3644 T14463 T14459 dobj response,show
R3645 T14464 T14463 amod small,response
R3646 T14465 T14463 prep to,response
R3647 T14466 T14465 pobj dDAVP,to
R3648 T14467 T14459 punct ", ",show
R3649 T14468 T14469 mark although,remains
R3650 T14469 T14459 advcl remains,show
R3651 T14470 T14471 npadvmod dDAVP,stimulated
R3652 T14471 T14473 amod stimulated,osmolality
R3653 T14472 T14471 punct -,stimulated
R3654 T14473 T14469 nsubj osmolality,remains
R3655 T14474 T14473 compound urine,osmolality
R3656 T14475 T14476 advmod quite,low
R3657 T14476 T14469 acomp low,remains
R3658 T14477 T14451 punct .,is
R3659 T14479 T14480 nsubj Immunostaining,shows
R3660 T14481 T14479 prep of,Immunostaining
R3661 T14482 T14481 pobj kidney,of
R3662 T14483 T14484 mark that,transport
R3663 T14484 T14480 ccomp transport,shows
R3664 T14485 T14486 compound AQP2,F204V
R3665 T14486 T14484 nsubj F204V,transport
R3666 T14487 T14486 punct -,F204V
R3667 T14488 T14484 aux does,transport
R3668 T14489 T14484 neg not,transport
R3669 T14490 T14484 advmod efficiently,transport
R3670 T14491 T14484 dobj water,transport
R3671 T14492 T14484 punct ", ",transport
R3672 T14493 T14494 mark because,fails
R3673 T14494 T14484 advcl fails,transport
R3674 T14495 T14494 nsubj it,fails
R3675 T14496 T14497 aux to,localize
R3676 T14497 T14494 xcomp localize,fails
R3677 T14498 T14497 prep to,localize
R3678 T14499 T14500 det the,surface
R3679 T14500 T14498 pobj surface,to
R3680 T14501 T14500 amod apical,surface
R3681 T14502 T14500 compound cell,surface
R3682 T14503 T14497 prep after,localize
R3683 T14504 T14505 compound dDAVP,treatment
R3684 T14505 T14503 pobj treatment,after
R3685 T14506 T14480 punct .,shows
R3686 T14508 T14509 det Some,activity
R3687 T14509 T14511 nsubj activity,imply
R3688 T14510 T14509 amod residual,activity
R3689 T14512 T14509 prep of,activity
R3690 T14513 T14512 pobj AQP2,of
R3691 T14514 T14511 aux would,imply
R3692 T14515 T14516 mark that,getting
R3693 T14516 T14511 ccomp getting,imply
R3694 T14517 T14518 det some,portion
R3695 T14518 T14516 nsubj portion,getting
R3696 T14519 T14518 amod small,portion
R3697 T14520 T14518 punct ", ",portion
R3698 T14521 T14518 amod undetectable,portion
R3699 T14522 T14518 prep of,portion
R3700 T14523 T14524 det the,protein
R3701 T14524 T14522 pobj protein,of
R3702 T14525 T14524 compound mutant,protein
R3703 T14526 T14516 aux is,getting
R3704 T14527 T14516 prep to,getting
R3705 T14528 T14529 det the,surface
R3706 T14529 T14527 pobj surface,to
R3707 T14530 T14529 compound cell,surface
R3708 T14531 T14511 punct .,imply
R3709 T14533 T14534 det The,experiment
R3710 T14534 T14537 nsubj experiment,suggests
R3711 T14535 T14534 compound surface,experiment
R3712 T14536 T14534 compound biotinylation,experiment
R3713 T14538 T14539 punct (,Figure
R3714 T14539 T14534 parataxis Figure,experiment
R3715 T14540 T14539 nummod 5D,Figure
R3716 T14541 T14539 punct ),Figure
R3717 T14542 T14543 mark that,gets
R3718 T14543 T14537 ccomp gets,suggests
R3719 T14544 T14545 det no,protein
R3720 T14545 T14543 nsubj protein,gets
R3721 T14546 T14545 compound mutant,protein
R3722 T14547 T14543 prep to,gets
R3723 T14548 T14549 det the,surface
R3724 T14549 T14547 pobj surface,to
R3725 T14550 T14537 punct ", ",suggests
R3726 T14551 T14537 cc but,suggests
R3727 T14552 T14553 nsubj this,reflect
R3728 T14553 T14537 conj reflect,suggests
R3729 T14554 T14553 aux does,reflect
R3730 T14555 T14553 neg not,reflect
R3731 T14556 T14553 advmod necessarily,reflect
R3732 T14557 T14558 det the,situation
R3733 T14558 T14553 dobj situation,reflect
R3734 T14559 T14560 advmod in,vivo
R3735 T14560 T14558 advmod vivo,situation
R3736 T14561 T14553 punct .,reflect
R3737 T14563 T14564 mark While,be
R3738 T14564 T14572 advcl be,shows
R3739 T14565 T14566 det this,fraction
R3740 T14566 T14564 nsubj fraction,be
R3741 T14567 T14566 amod small,fraction
R3742 T14568 T14566 prep of,fraction
R3743 T14569 T14568 pobj protein,of
R3744 T14570 T14564 aux may,be
R3745 T14571 T14564 neg not,be
R3746 T14573 T14564 acomp detectable,be
R3747 T14574 T14564 prep by,be
R3748 T14575 T14574 pobj immunofluorescence,by
R3749 T14576 T14572 punct ", ",shows
R3750 T14577 T14578 compound Western,blotting
R3751 T14578 T14572 nsubj blotting,shows
R3752 T14579 T14580 mark that,progress
R3753 T14580 T14572 ccomp progress,shows
R3754 T14581 T14582 det some,protein
R3755 T14582 T14580 nsubj protein,progress
R3756 T14583 T14582 compound mutant,protein
R3757 T14584 T14580 aux does,progress
R3758 T14585 T14580 prep beyond,progress
R3759 T14586 T14587 det the,ER
R3760 T14587 T14585 pobj ER,beyond
R3761 T14588 T14589 punct (,species
R3762 T14589 T14572 parataxis species,shows
R3763 T14590 T14591 quantmod 35,45
R3764 T14591 T14593 nummod 45,kDa
R3765 T14592 T14591 punct –,45
R3766 T14593 T14589 compound kDa,species
R3767 T14594 T14589 prep in,species
R3768 T14595 T14594 pobj Figure,in
R3769 T14596 T14595 nummod 3A,Figure
R3770 T14597 T14589 punct ),species
R3771 T14598 T14572 punct .,shows
R3772 T14600 T14601 prep Compared,is
R3773 T14602 T14600 prep to,Compared
R3774 T14603 T14604 amod wild,type
R3775 T14604 T14602 pobj type,to
R3776 T14605 T14604 punct -,type
R3777 T14606 T14601 punct ", ",is
R3778 T14607 T14608 compound mutant,protein
R3779 T14608 T14601 nsubj protein,is
R3780 T14609 T14601 acomp enriched,is
R3781 T14610 T14609 prep in,enriched
R3782 T14611 T14612 det the,form
R3783 T14612 T14610 pobj form,in
R3784 T14613 T14614 amod high,mannose
R3785 T14614 T14612 nmod mannose,form
R3786 T14615 T14614 punct -,mannose
R3787 T14616 T14612 punct ", ",form
R3788 T14617 T14618 npadvmod core,glycosylated
R3789 T14618 T14612 amod glycosylated,form
R3790 T14619 T14618 punct -,glycosylated
R3791 T14620 T14621 punct (,kDa
R3792 T14621 T14612 parataxis kDa,form
R3793 T14622 T14621 nummod 31,kDa
R3794 T14623 T14621 punct ),kDa
R3795 T14624 T14609 cc and,enriched
R3796 T14625 T14609 conj deficient,enriched
R3797 T14626 T14625 prep in,deficient
R3798 T14627 T14628 amod nonglycosylated,forms
R3799 T14628 T14626 pobj forms,in
R3800 T14629 T14630 punct (,kDa
R3801 T14630 T14627 parataxis kDa,nonglycosylated
R3802 T14631 T14630 nummod 29,kDa
R3803 T14632 T14630 punct ),kDa
R3804 T14633 T14627 cc and,nonglycosylated
R3805 T14634 T14635 amod complex,glycosylated
R3806 T14635 T14627 conj glycosylated,nonglycosylated
R3807 T14636 T14637 punct (,kDa
R3808 T14637 T14635 parataxis kDa,glycosylated
R3809 T14638 T14639 quantmod 35,45
R3810 T14639 T14637 nummod 45,kDa
R3811 T14640 T14639 punct –,45
R3812 T14641 T14637 punct ),kDa
R3813 T14642 T14601 punct .,is
R3814 T14644 T14645 det The,presence
R3815 T14645 T14646 nsubj presence,indicates
R3816 T14647 T14645 prep of,presence
R3817 T14648 T14649 det a,amount
R3818 T14649 T14647 pobj amount,of
R3819 T14650 T14649 amod reduced,amount
R3820 T14651 T14650 cc but,reduced
R3821 T14652 T14650 conj detectable,reduced
R3822 T14653 T14649 prep of,amount
R3823 T14654 T14653 pobj protein,of
R3824 T14655 T14654 prep in,protein
R3825 T14656 T14657 det the,range
R3826 T14657 T14655 pobj range,in
R3827 T14658 T14659 quantmod 35,45
R3828 T14659 T14661 nummod 45,kDa
R3829 T14660 T14659 punct –,45
R3830 T14661 T14657 compound kDa,range
R3831 T14662 T14663 mark that,transported
R3832 T14663 T14646 ccomp transported,indicates
R3833 T14664 T14665 compound mutant,protein
R3834 T14665 T14663 nsubjpass protein,transported
R3835 T14666 T14663 auxpass is,transported
R3836 T14667 T14663 prep out,transported
R3837 T14668 T14667 prep of,out
R3838 T14669 T14670 det the,ER
R3839 T14670 T14668 pobj ER,of
R3840 T14671 T14663 punct ", ",transported
R3841 T14672 T14673 cc but,with
R3842 T14673 T14663 prep with,transported
R3843 T14674 T14675 advmod greatly,reduced
R3844 T14675 T14676 amod reduced,efficiency
R3845 T14676 T14673 pobj efficiency,with
R3846 T14677 T14646 punct .,indicates
R3847 T14679 T14680 nsubj Colocalization,shows
R3848 T14681 T14679 prep of,Colocalization
R3849 T14682 T14683 compound AQP2,F204V
R3850 T14683 T14681 pobj F204V,of
R3851 T14684 T14683 punct -,F204V
R3852 T14685 T14679 prep with,Colocalization
R3853 T14686 T14687 det the,protein
R3854 T14687 T14685 pobj protein,with
R3855 T14688 T14687 compound ER,protein
R3856 T14689 T14687 appos calnexin,protein
R3857 T14690 T14679 prep in,Colocalization
R3858 T14691 T14692 amod transfected,cells
R3859 T14692 T14690 pobj cells,in
R3860 T14693 T14692 compound MDCK,cells
R3861 T14694 T14695 mark that,progress
R3862 T14695 T14680 ccomp progress,shows
R3863 T14696 T14695 punct ", ",progress
R3864 T14697 T14698 mark while,trapped
R3865 T14698 T14695 advcl trapped,progress
R3866 T14738 T14737 prep of,fraction
R3867 T14699 T14698 nsubjpass most,trapped
R3868 T14739 T14740 compound mutant,protein
R3869 T14700 T14699 prep of,most
R3870 T14740 T14738 pobj protein,of
R3871 T14741 T14734 prep beyond,transport
R3872 T14701 T14702 det the,protein
R3873 T14742 T14743 det the,ER
R3874 T14743 T14741 pobj ER,beyond
R3875 T14744 T14734 prep in,transport
R3876 T14702 T14700 pobj protein,of
R3877 T14745 T14746 compound MDCK,cells
R3878 T14746 T14744 pobj cells,in
R3879 T14747 T14718 advmod all,are
R3880 T14703 T14702 compound mutant,protein
R3881 T14748 T14718 acomp consistent,are
R3882 T14749 T14748 prep with,consistent
R3883 T14750 T14751 det the,notion
R3884 T14704 T14698 auxpass is,trapped
R3885 T14751 T14749 pobj notion,with
R3886 T14752 T14753 mark that,is
R3887 T14753 T14751 advcl is,notion
R3888 T14705 T14698 prep in,trapped
R3889 T14754 T14755 compound AQP2,F204V
R3890 T14755 T14757 compound F204V,misfolding
R3891 T14756 T14755 punct -,F204V
R3892 T14706 T14707 det the,ER
R3893 T14757 T14753 nsubj misfolding,is
R3894 T14758 T14753 acomp limited,is
R3895 T14759 T14753 cc and,is
R3896 T14760 T14761 mark that,retain
R3897 T14761 T14753 conj retain,is
R3898 T14762 T14761 nsubj it,retain
R3899 T14707 T14705 pobj ER,in
R3900 T14763 T14761 aux may,retain
R3901 T14764 T14765 det some,activity
R3902 T14765 T14761 dobj activity,retain
R3903 T14708 T14695 punct ", ",progress
R3904 T14766 T14765 amod residual,activity
R3905 T14767 T14768 npadvmod water,transporting
R3906 T14709 T14695 nsubj some,progress
R3907 T14768 T14765 amod transporting,activity
R3908 T14769 T14718 punct .,are
R3909 T14771 T14772 advmod Evidently,is
R3910 T14710 T14695 aux does,progress
R3911 T14773 T14774 det this,activity
R3912 T14774 T14772 nsubj activity,is
R3913 T14711 T14695 prep beyond,progress
R3914 T14775 T14774 amod residual,activity
R3915 T14712 T14713 det the,ER
R3916 T14776 T14772 acomp sufficient,is
R3917 T14777 T14776 prep for,sufficient
R3918 T14713 T14711 pobj ER,beyond
R3919 T14778 T14779 det the,viability
R3920 T14779 T14777 pobj viability,for
R3921 T14780 T14779 cc and,viability
R3922 T14714 T14680 punct .,shows
R3923 T14781 T14779 conj growth,viability
R3924 T14782 T14779 prep of,viability
R3925 T14783 T14784 compound mutant,animals
R3926 T14716 T14717 amod Diminished,response
R3927 T14784 T14782 pobj animals,of
R3928 T14785 T14772 punct .,is
R3930 T14717 T14718 nsubj response,are
R3933 T14719 T14717 prep to,response
R3938 T14720 T14719 pobj dDAVP,to
R3942 T14721 T14717 punct ", ",response
R3949 T14722 T14723 amod diminished,abundance
R3954 T14723 T14717 conj abundance,response
R3958 T14724 T14723 prep of,abundance
R3959 T14725 T14726 amod mature,protein
R3965 T14726 T14724 pobj protein,of
R3967 T14727 T14726 amod glycosylated,protein
R3971 T14728 T14723 prep in,abundance
R3975 T14729 T14730 compound mutant,animals
R3978 T14730 T14728 pobj animals,in
R3982 T14731 T14723 punct ", ",abundance
R3985 T14732 T14723 cc and,abundance
R3989 T14733 T14734 det the,transport
R3992 T14734 T14723 conj transport,abundance
R3995 T14735 T14734 prep of,transport
R3999 T14736 T14737 det a,fraction
R4000 T14737 T14735 pobj fraction,of

2_test

Id Subject Object Predicate Lexical cue
16121255-11035038-85587803 65-67 11035038 denotes 18
T96150 65-67 11035038 denotes 18