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PMC:1189073 / 0-1190 JSONTXT

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craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T530 22-26 NCBITaxon:10088 denotes Mice
T531 34-42 SO_EXT:sequence_alteration_entity_or_process denotes Mutation
T532 46-57 PR_EXT:000004182 denotes Aquaporin-2
T533 103-114 GO:0001822 denotes nephrogenic
T534 185-191 UBERON:0002113 denotes kidney
T535 207-212 UBERON:0001088 denotes urine
T536 216-224 GO_EXT:reaction_or_response denotes response
T537 228-239 CHEBI_PR_EXT:vasopressin denotes vasopressin
T538 241-246 NCBITaxon:9606 denotes Human
T539 261-272 GO:0001822 denotes nephrogenic
T540 318-327 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T541 335-346 CHEBI_PR_EXT:vasopressin denotes vasopressin
T542 335-355 GO_EXT:0005000 denotes vasopressin receptor
T543 335-357 PR_EXT:000001683 denotes vasopressin receptor 2
T544 359-364 PR_EXT:000001683 denotes Avpr2
T545 366-370 SO_EXT:0000704 denotes gene
T546 378-389 CHEBI_PR_EXT:vasopressin denotes vasopressin
T547 400-405 CHEBI:15377 denotes water
T548 400-413 GO_EXT:0015250 denotes water channel
T549 414-425 PR_EXT:000004182 denotes aquaporin-2
T550 427-431 PR_EXT:000004182 denotes Aqp2
T551 433-437 SO_EXT:0000704 denotes gene
T552 516-522 NCBITaxon:33208 denotes animal
T553 546-553 SO_EXT:0000704 denotes genetic
T554 567-583 CHEBI:23995 denotes ethylnitrosourea
T555 596-600 NCBITaxon:10088 denotes mice
T556 657-662 NCBITaxon:10088 denotes mouse
T557 691-699 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T558 707-711 PR_EXT:000004182 denotes Aqp2
T559 712-716 SO_EXT:0000704 denotes gene
T560 746-752 NCBITaxon:39107 denotes murine
T561 772-776 NCBITaxon:10088 denotes mice
T562 788-797 UBERON:0000113 denotes adulthood
T563 832-837 NCBITaxon:9606 denotes human
T564 884-889 UBERON:0002113 denotes renal
T565 884-894 CL:1000497 denotes renal cell
T566 890-894 CL_GO_EXT:cell denotes cell
T567 919-923 PR_EXT:000004182 denotes Aqp2
T568 924-933 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T569 953-964 GO_EXT:biological_routing_or_transport denotes trafficking
T570 972-978 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T571 979-984 CHEBI:15377 denotes water
T572 979-989 GO_EXT:0015250 denotes water pore
T573 1003-1010 NCBITaxon:33208 denotes animals
T574 1064-1068 PR_EXT:000004182 denotes AQP2
T575 1069-1082 GO_EXT:biological_translocation_entity_or_process denotes translocation
T576 1090-1099 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T577 1110-1121 GO:0001822 denotes nephrogenic
T578 1155-1163 NCBITaxon:1 denotes organism

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T490 22-26 NCBITaxon:10088 denotes Mice
T491 46-57 PR:000004182 denotes Aquaporin-2
T492 103-114 GO:0001822 denotes nephrogenic
T493 185-191 UBERON:0002113 denotes kidney
T494 207-212 UBERON:0001088 denotes urine
T495 241-246 NCBITaxon:9606 denotes Human
T496 261-272 GO:0001822 denotes nephrogenic
T497 335-357 PR:000001683 denotes vasopressin receptor 2
T498 359-364 PR:000001683 denotes Avpr2
T499 366-370 SO:0000704 denotes gene
T500 400-405 CHEBI:15377 denotes water
T501 414-425 PR:000004182 denotes aquaporin-2
T502 427-431 PR:000004182 denotes Aqp2
T503 433-437 SO:0000704 denotes gene
T504 516-522 NCBITaxon:33208 denotes animal
T505 546-553 SO:0000704 denotes genetic
T506 567-583 CHEBI:23995 denotes ethylnitrosourea
T507 596-600 NCBITaxon:10088 denotes mice
T508 657-662 NCBITaxon:10088 denotes mouse
T509 707-711 PR:000004182 denotes Aqp2
T510 712-716 SO:0000704 denotes gene
T511 746-752 NCBITaxon:39107 denotes murine
T512 772-776 NCBITaxon:10088 denotes mice
T513 788-797 UBERON:0000113 denotes adulthood
T514 832-837 NCBITaxon:9606 denotes human
T515 884-889 UBERON:0002113 denotes renal
T516 884-894 CL:1000497 denotes renal cell
T517 919-923 PR:000004182 denotes Aqp2
T518 979-984 CHEBI:15377 denotes water
T519 1003-1010 NCBITaxon:33208 denotes animals
T520 1064-1068 PR:000004182 denotes AQP2
T521 1110-1121 GO:0001822 denotes nephrogenic
T522 1155-1163 NCBITaxon:1 denotes organism

craft-sa-dev

Id Subject Object Predicate Lexical cue
T593 0-8 NN denotes Diabetes
T594 9-18 NN denotes Insipidus
T595 0-57 sentence denotes Diabetes Insipidus in Mice with a Mutation in Aquaporin-2
T596 19-21 IN denotes in
T597 22-26 NNS denotes Mice
T598 27-31 IN denotes with
T599 32-33 DT denotes a
T600 34-42 NN denotes Mutation
T601 43-45 IN denotes in
T602 46-55 NN denotes Aquaporin
T603 55-56 HYPH denotes -
T604 56-57 CD denotes 2
T607 57-240 sentence denotes Aquaporin-2 Mutant Mice Abstract Congenital nephrogenic diabetes insipidus (NDI) is a disease characterized by failure of the kidney to concentrate urine in response to vasopressin.
T608 92-102 JJ denotes Congenital
T609 124-133 NN denotes insipidus
T610 103-114 JJ denotes nephrogenic
T611 115-123 NN denotes diabetes
T612 140-142 VBZ denotes is
T613 134-135 -LRB- denotes (
T614 135-138 NN denotes NDI
T615 138-139 -RRB- denotes )
T616 143-144 DT denotes a
T617 145-152 NN denotes disease
T618 153-166 VBN denotes characterized
T619 167-169 IN denotes by
T620 170-177 NN denotes failure
T621 178-180 IN denotes of
T622 181-184 DT denotes the
T623 185-191 NN denotes kidney
T624 192-194 TO denotes to
T625 195-206 VB denotes concentrate
T626 207-212 NN denotes urine
T627 213-215 IN denotes in
T628 216-224 NN denotes response
T629 225-227 IN denotes to
T630 228-239 NN denotes vasopressin
T631 239-240 . denotes .
T632 240-438 sentence denotes Human kindreds with nephrogenic diabetes insipidus have been found to harbor mutations in the vasopressin receptor 2 (Avpr2) gene or the vasopressin-sensitive water channel aquaporin-2 (Aqp2) gene.
T633 241-246 JJ denotes Human
T634 247-255 NNS denotes kindreds
T635 302-307 VBN denotes found
T636 256-260 IN denotes with
T637 261-272 JJ denotes nephrogenic
T638 282-291 NN denotes insipidus
T639 273-281 NN denotes diabetes
T640 292-296 VBP denotes have
T641 297-301 VBN denotes been
T642 308-310 TO denotes to
T643 311-317 VB denotes harbor
T644 318-327 NNS denotes mutations
T645 328-330 IN denotes in
T646 331-334 DT denotes the
T647 366-370 NN denotes gene
T648 335-346 NN denotes vasopressin
T649 347-355 NN denotes receptor
T650 356-357 CD denotes 2
T651 358-359 -LRB- denotes (
T652 359-364 NN denotes Avpr2
T653 364-365 -RRB- denotes )
T654 371-373 CC denotes or
T655 374-377 DT denotes the
T656 433-437 NN denotes gene
T657 378-389 NN denotes vasopressin
T658 390-399 JJ denotes sensitive
T659 389-390 HYPH denotes -
T660 400-405 NN denotes water
T661 406-413 NN denotes channel
T662 414-423 NN denotes aquaporin
T663 423-424 HYPH denotes -
T664 424-425 CD denotes 2
T665 426-427 -LRB- denotes (
T666 427-431 NN denotes Aqp2
T667 431-432 -RRB- denotes )
T668 437-438 . denotes .
T669 438-529 sentence denotes Development of a treatment is rendered difficult due to the lack of a viable animal model.
T670 439-450 NN denotes Development
T671 469-477 VBN denotes rendered
T672 451-453 IN denotes of
T673 454-455 DT denotes a
T674 456-465 NN denotes treatment
T675 466-468 VBZ denotes is
T676 478-487 JJ denotes difficult
T677 488-491 IN denotes due
T678 492-494 IN denotes to
T679 495-498 DT denotes the
T680 499-503 NN denotes lack
T681 504-506 IN denotes of
T682 507-508 DT denotes a
T683 523-528 NN denotes model
T684 509-515 JJ denotes viable
T685 516-522 NN denotes animal
T686 528-529 . denotes .
T687 529-717 sentence denotes Through forward genetic screening of ethylnitrosourea-mutagenized mice, we report the identification and characterization of a mouse model of NDI, with an F204V mutation in the Aqp2 gene.
T688 530-537 IN denotes Through
T689 605-611 VBP denotes report
T690 538-545 JJ denotes forward
T691 554-563 NN denotes screening
T692 546-553 JJ denotes genetic
T693 564-566 IN denotes of
T694 567-583 NN denotes ethylnitrosourea
T695 584-595 VBN denotes mutagenized
T696 583-584 HYPH denotes -
T697 596-600 NNS denotes mice
T698 600-602 , denotes ,
T699 602-604 PRP denotes we
T700 612-615 DT denotes the
T701 616-630 NN denotes identification
T702 631-634 CC denotes and
T703 635-651 NN denotes characterization
T704 652-654 IN denotes of
T705 655-656 DT denotes a
T706 663-668 NN denotes model
T707 657-662 NN denotes mouse
T708 669-671 IN denotes of
T709 672-675 NN denotes NDI
T710 675-677 , denotes ,
T711 677-681 IN denotes with
T712 682-684 DT denotes an
T713 691-699 NN denotes mutation
T714 685-690 NN denotes F204V
T715 700-702 IN denotes in
T716 703-706 DT denotes the
T717 712-716 NN denotes gene
T718 707-711 NN denotes Aqp2
T719 716-717 . denotes .
T720 717-847 sentence denotes Unlike previously attempted murine models of NDI, our mice survive to adulthood and more exactly recapitulate the human disorder.
T721 718-724 IN denotes Unlike
T722 777-784 VBP denotes survive
T723 725-735 RB denotes previously
T724 736-745 VBN denotes attempted
T725 753-759 NNS denotes models
T726 746-752 JJ denotes murine
T727 760-762 IN denotes of
T728 763-766 NN denotes NDI
T729 766-768 , denotes ,
T730 768-771 PRP$ denotes our
T731 772-776 NNS denotes mice
T732 785-787 IN denotes to
T733 788-797 NN denotes adulthood
T734 798-801 CC denotes and
T735 802-806 RBR denotes more
T736 807-814 RB denotes exactly
T737 815-827 VBP denotes recapitulate
T738 828-831 DT denotes the
T739 838-846 NN denotes disorder
T740 832-837 JJ denotes human
T741 846-847 . denotes .
T742 847-990 sentence denotes Previous in vitro experiments using renal cell lines suggest recessive Aqp2 mutations result in improper trafficking of the mutant water pore.
T743 848-856 JJ denotes Previous
T744 866-877 NNS denotes experiments
T745 857-859 FW denotes in
T746 860-865 FW denotes vitro
T747 901-908 VBP denotes suggest
T748 878-883 VBG denotes using
T749 884-889 JJ denotes renal
T750 895-900 NNS denotes lines
T751 890-894 NN denotes cell
T752 909-918 JJ denotes recessive
T753 924-933 NNS denotes mutations
T754 919-923 NN denotes Aqp2
T755 934-940 VBP denotes result
T756 941-943 IN denotes in
T757 944-952 JJ denotes improper
T758 953-964 NN denotes trafficking
T759 965-967 IN denotes of
T760 968-971 DT denotes the
T761 985-989 NN denotes pore
T762 972-978 JJ denotes mutant
T763 979-984 NN denotes water
T764 989-990 . denotes .
T765 990-1164 sentence denotes Using these animals, we have directly proven this hypothesis of improper AQP2 translocation as the molecular defect in nephrogenic diabetes insipidus in the intact organism.
T766 991-996 VBG denotes Using
T767 1029-1035 VBN denotes proven
T768 997-1002 DT denotes these
T769 1003-1010 NNS denotes animals
T770 1010-1012 , denotes ,
T771 1012-1014 PRP denotes we
T772 1015-1019 VBP denotes have
T773 1020-1028 RB denotes directly
T774 1036-1040 DT denotes this
T775 1041-1051 NN denotes hypothesis
T776 1052-1054 IN denotes of
T777 1055-1063 JJ denotes improper
T778 1069-1082 NN denotes translocation
T779 1064-1068 NN denotes AQP2
T780 1083-1085 IN denotes as
T781 1086-1089 DT denotes the
T782 1100-1106 NN denotes defect
T783 1090-1099 JJ denotes molecular
T784 1107-1109 IN denotes in
T785 1110-1121 JJ denotes nephrogenic
T786 1131-1140 NN denotes insipidus
T787 1122-1130 NN denotes diabetes
T788 1141-1143 IN denotes in
T789 1144-1147 DT denotes the
T790 1155-1163 NN denotes organism
T791 1148-1154 JJ denotes intact
T792 1163-1164 . denotes .
T794 1165-1177 RB denotes Additionally
T796 1177-1179 , denotes ,
T797 1179-1184 VBG denotes using
T798 1185-1186 DT denotes a
R12 T609 T612 nsubj insipidus,is
R13 T610 T609 amod nephrogenic,insipidus
R14 T611 T609 compound diabetes,insipidus
R38 T638 T636 pobj insipidus,with
R39 T639 T638 compound diabetes,insipidus
R47 T647 T645 pobj gene,in
R48 T648 T649 nmod vasopressin,receptor
R49 T649 T647 nmod receptor,gene
R50 T650 T649 nummod 2,receptor
R51 T651 T649 punct (,receptor
R52 T652 T649 appos Avpr2,receptor
R53 T653 T647 punct ),gene
R56 T656 T647 conj gene,gene
R57 T657 T658 npadvmod vasopressin,sensitive
R59 T659 T658 punct -,sensitive
R60 T660 T661 nmod water,channel
R61 T661 T656 nmod channel,gene
R62 T662 T656 nmod aquaporin,gene
R63 T663 T662 punct -,aquaporin
R64 T664 T662 nummod 2,aquaporin
R65 T665 T662 punct (,aquaporin
R66 T666 T662 appos Aqp2,aquaporin
R67 T667 T656 punct ),gene
R81 T683 T681 pobj model,of
R82 T684 T683 amod viable,model
R83 T685 T683 compound animal,model
R87 T691 T688 pobj screening,Through
R88 T692 T691 amod genetic,screening
R91 T695 T697 amod mutagenized,mice
R92 T696 T695 punct -,mutagenized
R102 T706 T704 pobj model,of
R103 T707 T706 compound mouse,model
R109 T713 T711 pobj mutation,with
R110 T714 T713 compound F204V,mutation
R113 T717 T715 pobj gene,in
R114 T718 T717 compound Aqp2,gene
R119 T725 T721 pobj models,Unlike
R120 T726 T725 amod murine,models
R133 T739 T737 dobj disorder,recapitulate
R134 T740 T739 amod human,disorder
R137 T744 T747 nsubj experiments,suggest
R138 T745 T746 advmod in,vitro
R139 T746 T744 amod vitro,experiments
R142 T750 T748 dobj lines,using
R143 T751 T750 compound cell,lines
R145 T753 T755 nsubj mutations,result
R146 T754 T753 compound Aqp2,mutations
R153 T761 T759 pobj pore,of
R154 T762 T761 amod mutant,pore
R155 T763 T761 compound water,pore
R168 T778 T776 pobj translocation,of
R169 T779 T778 compound AQP2,translocation
R172 T782 T780 pobj defect,as
R173 T783 T782 amod molecular,defect
R176 T786 T784 pobj insipidus,in
R177 T787 T786 compound diabetes,insipidus
R180 T790 T788 pobj organism,in
R181 T791 T790 amod intact,organism
R45 T645 T643 prep in,harbor
R46 T646 T647 det the,gene
R54 T654 T647 cc or,gene
R55 T655 T656 det the,gene
R58 T658 T656 amod sensitive,gene
R1 T593 T594 compound Diabetes,Insipidus
R2 T596 T594 prep in,Insipidus
R3 T597 T596 pobj Mice,in
R4 T598 T597 prep with,Mice
R5 T599 T600 det a,Mutation
R6 T600 T598 pobj Mutation,with
R7 T601 T600 prep in,Mutation
R8 T602 T601 pobj Aquaporin,in
R9 T603 T602 punct -,Aquaporin
R10 T604 T602 nummod 2,Aquaporin
R11 T608 T609 amod Congenital,insipidus
R15 T613 T609 punct (,insipidus
R16 T614 T609 appos NDI,insipidus
R17 T615 T609 punct ),insipidus
R18 T616 T617 det a,disease
R19 T617 T612 attr disease,is
R20 T618 T617 acl characterized,disease
R21 T619 T618 agent by,characterized
R22 T620 T619 pobj failure,by
R23 T621 T620 prep of,failure
R24 T622 T623 det the,kidney
R25 T623 T621 pobj kidney,of
R26 T624 T625 aux to,concentrate
R27 T625 T620 acl concentrate,failure
R28 T626 T625 dobj urine,concentrate
R29 T627 T625 prep in,concentrate
R30 T628 T627 pobj response,in
R31 T629 T628 prep to,response
R32 T630 T629 pobj vasopressin,to
R33 T631 T612 punct .,is
R34 T633 T634 amod Human,kindreds
R35 T634 T635 nsubjpass kindreds,found
R36 T636 T634 prep with,kindreds
R37 T637 T638 amod nephrogenic,insipidus
R40 T640 T635 aux have,found
R41 T641 T635 auxpass been,found
R42 T642 T643 aux to,harbor
R43 T643 T635 xcomp harbor,found
R44 T644 T643 dobj mutations,harbor
R68 T668 T635 punct .,found
R69 T670 T671 nsubjpass Development,rendered
R70 T672 T670 prep of,Development
R71 T673 T674 det a,treatment
R72 T674 T672 pobj treatment,of
R73 T675 T671 auxpass is,rendered
R74 T676 T671 oprd difficult,rendered
R75 T677 T671 prep due,rendered
R76 T678 T677 pcomp to,due
R77 T679 T680 det the,lack
R78 T680 T677 pobj lack,due
R79 T681 T680 prep of,lack
R80 T682 T683 det a,model
R84 T686 T671 punct .,rendered
R85 T688 T689 prep Through,report
R86 T690 T691 amod forward,screening
R89 T693 T691 prep of,screening
R90 T694 T695 npadvmod ethylnitrosourea,mutagenized
R93 T697 T693 pobj mice,of
R94 T698 T689 punct ", ",report
R95 T699 T689 nsubj we,report
R96 T700 T701 det the,identification
R97 T701 T689 dobj identification,report
R98 T702 T701 cc and,identification
R99 T703 T701 conj characterization,identification
R100 T704 T701 prep of,identification
R101 T705 T706 det a,model
R104 T708 T706 prep of,model
R105 T709 T708 pobj NDI,of
R106 T710 T706 punct ", ",model
R107 T711 T706 prep with,model
R108 T712 T713 det an,mutation
R111 T715 T713 prep in,mutation
R112 T716 T717 det the,gene
R115 T719 T689 punct .,report
R116 T721 T722 prep Unlike,survive
R117 T723 T724 advmod previously,attempted
R118 T724 T725 amod attempted,models
R121 T727 T725 prep of,models
R122 T728 T727 pobj NDI,of
R123 T729 T722 punct ", ",survive
R124 T730 T731 poss our,mice
R125 T731 T722 nsubj mice,survive
R126 T732 T722 prep to,survive
R127 T733 T732 pobj adulthood,to
R128 T734 T722 cc and,survive
R129 T735 T736 advmod more,exactly
R130 T736 T737 advmod exactly,recapitulate
R131 T737 T722 conj recapitulate,survive
R132 T738 T739 det the,disorder
R135 T741 T722 punct .,survive
R136 T743 T744 amod Previous,experiments
R140 T748 T744 acl using,experiments
R141 T749 T750 amod renal,lines
R144 T752 T753 amod recessive,mutations
R147 T755 T747 advcl result,suggest
R148 T756 T755 prep in,result
R149 T757 T758 amod improper,trafficking
R150 T758 T756 pobj trafficking,in
R151 T759 T758 prep of,trafficking
R152 T760 T761 det the,pore
R156 T764 T747 punct .,suggest
R157 T766 T767 advcl Using,proven
R158 T768 T769 det these,animals
R159 T769 T766 dobj animals,Using
R160 T770 T767 punct ", ",proven
R161 T771 T767 nsubj we,proven
R162 T772 T767 aux have,proven
R163 T773 T767 advmod directly,proven
R164 T774 T775 det this,hypothesis
R165 T775 T767 dobj hypothesis,proven
R166 T776 T775 prep of,hypothesis
R167 T777 T778 amod improper,translocation
R170 T780 T778 prep as,translocation
R171 T781 T782 det the,defect
R174 T784 T782 prep in,defect
R175 T785 T786 amod nephrogenic,insipidus
R178 T788 T782 prep in,defect
R179 T789 T790 det the,organism
R182 T792 T767 punct .,proven