PMC:1186732 / 4801-5467 JSONTXT

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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1186732","sourcedb":"PMC","sourceid":"1186732","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1186732","text":"Mutations in the mouse ortholog of NR2E3 have been identified in the spontaneous mutant retinal degeneration 7 (rd7) [15]. This mutant demonstrates slow retinal degeneration and abnormal lamination of the ONL with rosette formation [15,16]. Curiously, the ERG of the mouse under both light and dark adaptation has been reported to be normal, showing progressive attenuation with time, presumably due to degenerative cell loss [15]. A prior study showed a 2- to 3-fold increase in the number S-opsin–positive cells in the rd7 retina compared to wild type [17]. 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