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in Retinal Transcription Factor and Müller Glial Gene Expression in rd7\nAnalysis of several photoreceptor transcription factors in the rd7 mutant indicated that the levels of Crx and Nrl are unaffected in the mutant at P14 (see Figure 2, lower right photomicrographs). Nrl is a rod-specific, basic leucine zipper transcription factor required for the activation of many rod-specific genes and the repression of most cone-specific genes in rods [24]. Nrl is known to be genetically upstream of Nr2e3 and is required for its expression [24]. Crx is a homeobox transcription factor expressed in both rods and cones and is required for the expression of a variety of rod- and cone-specific genes [25]. In contrast to what is seen in the Nrl mutant, Nr2e3 expression is unchanged in Crx mutant homozygotes (unpublished data).\nStrikingly, Nr2e3 itself was markedly up-regulated in the rd7 mutant both by microarray and in situ hybridization (see Figure 2, lower right photomicrographs; Table S2). The rd7 mutant carries a deletion in Nr2e3 that removes portions of both the DNA-binding and ligand-binding domains [15]. Although this deletion most likely creates a null allele, a residual transcript is clearly present and up-regulated in the rd7 mutant. This finding suggests that Nr2e3 is required for repression of its own transcription.\nOne gene, RIKEN cDNA 4933409K07 (Figure 1, gene G47), was found to be up-regulated on microarray at all four timepoints examined. This gene showed a unique pattern of expression in the adult rd7 mutant retina. Whereas there was only a barely detectable hint of expression in the inner nuclear layer (INL) in the wild-type retina, this gene showed strong expression in the middle and vitreal thirds of the INL as well as patchy expression in the ganglion cell layer (GCL) and at the scleral edge of the ONL in rd7 (see Table S1). This in situ hybridization pattern is consistent with staining in Müller glia, the principal glial cell type of the mouse retina. One possible interpretation of this unusual expression pattern is that it represents an early reaction of Müller glia to injury in this mutant."}

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in Retinal Transcription Factor and Müller Glial Gene Expression in rd7\nAnalysis of several photoreceptor transcription factors in the rd7 mutant indicated that the levels of Crx and Nrl are unaffected in the mutant at P14 (see Figure 2, lower right photomicrographs). Nrl is a rod-specific, basic leucine zipper transcription factor required for the activation of many rod-specific genes and the repression of most cone-specific genes in rods [24]. Nrl is known to be genetically upstream of Nr2e3 and is required for its expression [24]. Crx is a homeobox transcription factor expressed in both rods and cones and is required for the expression of a variety of rod- and cone-specific genes [25]. In contrast to what is seen in the Nrl mutant, Nr2e3 expression is unchanged in Crx mutant homozygotes (unpublished data).\nStrikingly, Nr2e3 itself was markedly up-regulated in the rd7 mutant both by microarray and in situ hybridization (see Figure 2, lower right photomicrographs; Table S2). The rd7 mutant carries a deletion in Nr2e3 that removes portions of both the DNA-binding and ligand-binding domains [15]. Although this deletion most likely creates a null allele, a residual transcript is clearly present and up-regulated in the rd7 mutant. This finding suggests that Nr2e3 is required for repression of its own transcription.\nOne gene, RIKEN cDNA 4933409K07 (Figure 1, gene G47), was found to be up-regulated on microarray at all four timepoints examined. This gene showed a unique pattern of expression in the adult rd7 mutant retina. Whereas there was only a barely detectable hint of expression in the inner nuclear layer (INL) in the wild-type retina, this gene showed strong expression in the middle and vitreal thirds of the INL as well as patchy expression in the ganglion cell layer (GCL) and at the scleral edge of the ONL in rd7 (see Table S1). This in situ hybridization pattern is consistent with staining in Müller glia, the principal glial cell type of the mouse retina. One possible interpretation of this unusual expression pattern is that it represents an early reaction of Müller glia to injury in this mutant."}

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Nrl is a rod-specific, basic leucine zipper transcription factor required for the activation of many rod-specific genes and the repression of most cone-specific genes in rods [24]. Nrl is known to be genetically upstream of Nr2e3 and is required for its expression [24]. Crx is a homeobox transcription factor expressed in both rods and cones and is required for the expression of a variety of rod- and cone-specific genes [25]. In contrast to what is seen in the Nrl mutant, Nr2e3 expression is unchanged in Crx mutant homozygotes (unpublished data).\nStrikingly, Nr2e3 itself was markedly up-regulated in the rd7 mutant both by microarray and in situ hybridization (see Figure 2, lower right photomicrographs; Table S2). The rd7 mutant carries a deletion in Nr2e3 that removes portions of both the DNA-binding and ligand-binding domains [15]. Although this deletion most likely creates a null allele, a residual transcript is clearly present and up-regulated in the rd7 mutant. This finding suggests that Nr2e3 is required for repression of its own transcription.\nOne gene, RIKEN cDNA 4933409K07 (Figure 1, gene G47), was found to be up-regulated on microarray at all four timepoints examined. This gene showed a unique pattern of expression in the adult rd7 mutant retina. Whereas there was only a barely detectable hint of expression in the inner nuclear layer (INL) in the wild-type retina, this gene showed strong expression in the middle and vitreal thirds of the INL as well as patchy expression in the ganglion cell layer (GCL) and at the scleral edge of the ONL in rd7 (see Table S1). This in situ hybridization pattern is consistent with staining in Müller glia, the principal glial cell type of the mouse retina. One possible interpretation of this unusual expression pattern is that it represents an early reaction of Müller glia to injury in this mutant."}

{"project":"2_test","denotations":[{"id":"16110338-11694879-85798521","span":{"begin":453,"end":455},"obj":"11694879"},{"id":"16110338-11694879-85798522","span":{"begin":543,"end":545},"obj":"11694879"},{"id":"16110338-10581037-85798523","span":{"begin":701,"end":703},"obj":"10581037"},{"id":"16110338-10805811-85798524","span":{"begin":1116,"end":1118},"obj":"10805811"},{"id":"T85266","span":{"begin":453,"end":455},"obj":"11694879"},{"id":"T4282","span":{"begin":543,"end":545},"obj":"11694879"},{"id":"T41962","span":{"begin":701,"end":703},"obj":"10581037"},{"id":"T8041","span":{"begin":1116,"end":1118},"obj":"10805811"}],"text":"Changes in Retinal Transcription Factor and Müller Glial Gene Expression in rd7\nAnalysis of several photoreceptor transcription factors in the rd7 mutant indicated that the levels of Crx and Nrl are unaffected in the mutant at P14 (see Figure 2, lower right photomicrographs). Nrl is a rod-specific, basic leucine zipper transcription factor required for the activation of many rod-specific genes and the repression of most cone-specific genes in rods [24]. Nrl is known to be genetically upstream of Nr2e3 and is required for its expression [24]. Crx is a homeobox transcription factor expressed in both rods and cones and is required for the expression of a variety of rod- and cone-specific genes [25]. In contrast to what is seen in the Nrl mutant, Nr2e3 expression is unchanged in Crx mutant homozygotes (unpublished data).\nStrikingly, Nr2e3 itself was markedly up-regulated in the rd7 mutant both by microarray and in situ hybridization (see Figure 2, lower right photomicrographs; Table S2). The rd7 mutant carries a deletion in Nr2e3 that removes portions of both the DNA-binding and ligand-binding domains [15]. Although this deletion most likely creates a null allele, a residual transcript is clearly present and up-regulated in the rd7 mutant. This finding suggests that Nr2e3 is required for repression of its own transcription.\nOne gene, RIKEN cDNA 4933409K07 (Figure 1, gene G47), was found to be up-regulated on microarray at all four timepoints examined. This gene showed a unique pattern of expression in the adult rd7 mutant retina. Whereas there was only a barely detectable hint of expression in the inner nuclear layer (INL) in the wild-type retina, this gene showed strong expression in the middle and vitreal thirds of the INL as well as patchy expression in the ganglion cell layer (GCL) and at the scleral edge of the ONL in rd7 (see Table S1). This in situ hybridization pattern is consistent with staining in Müller glia, the principal glial cell type of the mouse retina. One possible interpretation of this unusual expression pattern is that it represents an early reaction of Müller glia to injury in this mutant."}