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PMC:1183529 / 6797-21265 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T5066 38-42 UBERON:0002048 denotes lung
T5067 55-59 PR:000017653 denotes Fog2
T5068 100-103 CHEBI:23995 denotes ENU
T5069 116-120 NCBITaxon:10088 denotes mice
T5070 124-133 UBERON:0000922 denotes embryonic
T5071 207-211 NCBITaxon:10088 denotes mice
T5072 239-246 UBERON:0000922 denotes embryos
T5073 285-294 UBERON:0002048 denotes pulmonary
T5074 317-326 UBERON:0001103 denotes diaphragm
T5075 365-369 UBERON:0002048 denotes lung
T5076 441-450 SO:0001024 denotes haplotype
T5077 613-617 NCBITaxon:10088 denotes mice
T5078 957-965 SO:0000357 denotes flanking
T5079 1035-1044 UBERON:0002048 denotes pulmonary
T5080 1072-1081 UBERON:0001103 denotes diaphragm
T5081 1083-1092 UBERON:0002048 denotes Pulmonary
T5082 1131-1135 NCBITaxon:10088 denotes mice
T5083 1153-1158 GO:0007567 denotes birth
T5084 1205-1209 NCBITaxon:10088 denotes mice
T5085 1235-1239 UBERON:0000104 denotes life
T5086 1287-1291 UBERON:0002048 denotes lung
T5087 1339-1343 NCBITaxon:10088 denotes mice
T5088 1364-1368 UBERON:0002048 denotes lung
T5089 1421-1425 UBERON:0002048 denotes lung
T5090 1468-1473 UBERON:0002048 denotes lungs
T5091 1486-1490 NCBITaxon:10088 denotes mice
T5092 1517-1521 UBERON:0009912 denotes lobe
T5093 1594-1598 UBERON:0009912 denotes lobe
T5094 1612-1622 UBERON:0001103 denotes Diaphragms
T5095 1639-1643 NCBITaxon:10088 denotes mice
T5096 1711-1721 CL:0002372 denotes Myotubules
T5097 1794-1804 CL:0002372 denotes myotubules
T5098 1868-1878 UBERON:0000309 denotes body walls
T5099 1905-1918 CL:0000187 denotes muscle fibers
T5100 1926-1943 UBERON:0006670 denotes central tendonous
T5101 1966-1975 UBERON:0001103 denotes diaphragm
T5102 1977-1987 CL:0002372 denotes myotubules
T5103 2034-2047 UBERON:0002385 denotes muscle tissue
T5104 2087-2097 UBERON:0000309 denotes body walls
T5105 2592-2596 NCBITaxon:10088 denotes mice
T5106 2614-2619 GO:0007567 denotes birth
T5107 2744-2753 UBERON:0000922 denotes embryonic
T5108 2823-2830 UBERON:0000995 denotes uterine
T5109 2831-2837 GO:0016265 denotes demise
T5110 2904-2911 UBERON:0000922 denotes embryos
T5111 2963-2970 UBERON:0000995 denotes uterine
T5112 2971-2977 GO:0016265 denotes demise
T5113 3021-3027 UBERON:0000479 denotes tissue
T5114 3044-3051 UBERON:0000922 denotes embryos
T5115 3087-3093 GO:0016265 denotes demise
T5116 3265-3269 GO:0016265 denotes died
T5117 3339-3346 UBERON:0000922 denotes embryos
T5118 3370-3374 GO:0016265 denotes died
T5119 3397-3404 UBERON:0000922 denotes embryos
T5120 3463-3469 UBERON:0000922 denotes embryo
T5121 3482-3495 UBERON:0001103 denotes Diaphragmatic
T5122 3539-3543 NCBITaxon:10088 denotes mice
T5123 3563-3572 UBERON:0002048 denotes Pulmonary
T5125 3694-3701 UBERON:0000948 denotes cardiac
T5126 3725-3731 UBERON:0000948 denotes hearts
T5127 3754-3758 NCBITaxon:10088 denotes mice
T5128 3843-3863 UBERON:0002062 denotes endocardial cushions
T5129 3874-3880 UBERON:0004145 denotes outlet
T5130 3881-3896 UBERON:0002080 denotes right ventricle
T5131 3913-3935 UBERON:0002087 denotes atrioventricular canal
T5132 3941-3951 UBERON:0002349 denotes myocardium
T5133 4006-4019 UBERON:0004125 denotes compact layer
T5134 4068-4072 NCBITaxon:10088 denotes mice
T5135 4090-4095 GO:0007567 denotes birth
T5136 4105-4112 UBERON:0000948 denotes cardiac
T5137 4137-4159 UBERON:0002087 denotes atrioventricular-canal
T5138 4165-4183 UBERON:0002094 denotes ventricular septal
T5139 4193-4206 UBERON:0009149 denotes ostium primum
T5140 4207-4220 UBERON:0002085 denotes atrial septal
T5141 4243-4248 UBERON:0002081 denotes atria
T5142 4308-4315 UBERON:0000948 denotes cardiac
T5143 4348-4355 UBERON:0000948 denotes cardiac
T5144 4348-4367 GO:0007507 denotes cardiac development
T5145 4470-4485 SO:0000996 denotes predicted genes
T5146 4501-4506 SO:0000704 denotes genes
T5147 4518-4522 PR:000017653 denotes Fog2
T5148 4546-4550 PR:000017653 denotes Fog2
T5149 4556-4563 UBERON:0000948 denotes cardiac
T5150 4628-4632 NCBITaxon:10088 denotes mice
T5151 4644-4666 UBERON:0002087 denotes atrioventricular canal
T5152 4684-4694 UBERON:0002349 denotes myocardium
T5153 4707-4715 UBERON:0005985 denotes coronary
T5154 4716-4727 UBERON:0002049 denotes vasculature
T5155 4782-4786 PR:000017653 denotes Fog2
T5156 4803-4814 SO:0000673 denotes transcripts
T5157 4855-4862 UBERON:0000922 denotes embryos
T5158 4901-4911 SO:0000673 denotes transcript
T5159 4967-4969 SO:0000028 denotes bp
T5160 5006-5012 GO:0008380 denotes splice
T5161 5048-5052 SO:0000147 denotes exon
T5162 5077-5085 GO:0008380 denotes splicing
T5163 5129-5131 SO:0000028 denotes bp
T5164 5135-5143 SO:0000188 denotes intronic
T5165 5169-5179 SO:0000673 denotes transcript
T5166 5198-5208 SO:0000319 denotes stop codon
T5167 5298-5302 NCBITaxon:10088 denotes mice
T5168 5323-5327 PR:000017653 denotes Fog2
T5169 5338-5344 SO:0001023 denotes allele
T5170 5366-5370 SO:0000704 denotes gene
T5171 5407-5411 NCBITaxon:10088 denotes mice
T5172 5419-5428 UBERON:0000922 denotes embryonic
T5173 5507-5511 PR:000017653 denotes Fog2
T5174 5543-5547 NCBITaxon:10088 denotes mice
T5175 5580-5584 PR:000017653 denotes Fog2
T5176 5655-5665 SO:0000673 denotes transcript
T5177 5694-5700 GO:0008380 denotes splice
T5178 5694-5705 SO:0000162 denotes splice site
T7827 6141-6145 UBERON:0002048 denotes Lung
T7828 6141-6145 _FRAGMENT denotes Lung
T7829 6160-6171 GO:0030324 denotes Development
T7830 6150-6159 UBERON:0001103 denotes Diaphragm
T7831 6150-6171 GO:0060539 denotes Diaphragm Development
T7832 6179-6183 PR:000017653 denotes Fog2
T7833 6191-6196 NCBITaxon:10088 denotes Mouse
T7834 6248-6252 PR:000017653 denotes Fog2
T7835 6256-6265 UBERON:0002048 denotes pulmonary
T7836 6256-6265 _FRAGMENT denotes pulmonary
T7837 6284-6295 GO:0030324 denotes development
T7838 6270-6283 UBERON:0001103 denotes diaphragmatic
T7839 6270-6295 GO:0060539 denotes diaphragmatic development
T7840 6301-6310 UBERON:0002048 denotes pulmonary
T7841 6395-6399 UBERON:0009912 denotes lobe
T7842 6434-6438 UBERON:0009912 denotes lobe
T7843 6492-6505 UBERON:0001103 denotes diaphragmatic
T7844 6492-6517 GO:0060539 denotes diaphragmatic development
T7845 6563-6572 UBERON:0002048 denotes pulmonary
T7846 6670-6674 PR:000017653 denotes Fog2
T7847 6678-6687 GO:0010467 denotes expressed
T7848 6705-6725 UBERON:0004883 denotes pulmonary mesenchyme
T7849 6747-6770 GO:0001763 denotes branching morphogenesis
T7850 6784-6794 GO:0010467 denotes expression
T7851 6816-6830 UBERON:0001135 denotes smooth muscles
T7852 6834-6841 UBERON:0001005 denotes airways
T7853 6846-6855 UBERON:0002048 denotes pulmonary
T7854 6856-6863 UBERON:0000055 denotes vessels
T7855 6907-6912 UBERON:0002048 denotes lungs
T7856 6970-6983 UBERON:0001103 denotes diaphragmatic
T7857 7031-7040 UBERON:0002048 denotes pulmonary
T7858 7080-7093 UBERON:0001103 denotes diaphragmatic
T7859 7127-7132 UBERON:0002048 denotes lungs
T7860 7153-7157 PR:000017653 denotes Fog2
T7861 7162-7166 NCBITaxon:10088 denotes mice
T7862 7217-7230 UBERON:0001103 denotes diaphragmatic
T7863 7239-7243 PR:000017653 denotes Fog2
T7864 7248-7252 NCBITaxon:10088 denotes mice
T7865 7371-7376 UBERON:0002048 denotes Lungs
T7866 7399-7403 PR:000017653 denotes Fog2
T7867 7408-7415 UBERON:0000922 denotes embryos
T7868 7480-7484 UBERON:0009912 denotes lobe
T7869 7499-7503 PR:000017653 denotes Fog2
T7870 7508-7512 UBERON:0002048 denotes lung
T7871 7575-7579 UBERON:0009912 denotes lobe
T7872 7607-7612 UBERON:0002048 denotes lungs
T7873 7733-7742 UBERON:0002048 denotes pulmonary
T7874 7757-7761 PR:000017653 denotes Fog2
T7875 7769-7773 NCBITaxon:10088 denotes mice
T7876 8435-8440 UBERON:0009912 denotes lobes
T7877 8550-8555 UBERON:0009912 denotes lobes
T7878 8591-8595 PR:000017653 denotes Fog2
T7879 8631-8636 UBERON:0009912 denotes lobar
T7880 8666-8670 PR:000017653 denotes Fog2
T7881 8671-8681 GO:0010467 denotes expression
T7882 8706-8713 UBERON:0000922 denotes embryos
T7883 8741-8746 UBERON:0009912 denotes lobar
T7884 8782-8786 PR:000017653 denotes Fog2
T7885 8787-8797 GO:0010467 denotes expression
T7886 8833-8838 UBERON:0009912 denotes lobar
T7887 8845-8855 GO:0010467 denotes Expression
T7888 8873-8877 NCBITaxon:10088 denotes mice
T7889 8889-8893 PR:000033987 denotes lacZ
T7890 8894-8898 SO:0000704 denotes gene
T7891 8921-8925 PR:000017653 denotes Fog2
T7892 8973-8977 NCBITaxon:10088 denotes mice
T7893 9001-9006 UBERON:0002048 denotes lungs
T7894 9040-9044 PR:000017653 denotes Fog2
T7895 9045-9055 GO:0010467 denotes expression
T7896 9063-9073 UBERON:0003104 denotes mesenchyme
T7897 9125-9129 UBERON:0009912 denotes lobe
T7898 9149-9154 UBERON:0009912 denotes lobes
T7899 9187-9191 PR:000017653 denotes Fog2
T7900 9199-9203 NCBITaxon:10088 denotes mice
T7901 9226-9236 GO:0010467 denotes expression
T7902 9256-9276 UBERON:0004883 denotes pulmonary mesenchyme
T7903 9314-9327 GO:0097617 denotes hybridization
T7904 9331-9337 UBERON:0000479 denotes tissue
T7905 9622-9632 UBERON:0001103 denotes Diaphragms
T7906 9638-9642 PR:000017653 denotes Fog2
T7907 9647-9651 NCBITaxon:10088 denotes mice
T7908 9760-9769 UBERON:0001103 denotes diaphragm
T7909 9812-9834 CL:0000680 denotes muscle precursor cells
T7910 9850-9855 UBERON:0002101 denotes limbs
T7911 9865-9869 NCBITaxon:10088 denotes Mice
T7912 9886-9891 SO:0000704 denotes genes
T7913 9922-9929 GO:0065007 denotes control
T7914 9972-9982 UBERON:0001103 denotes diaphragms
T7915 9995-10005 CL:0000182 denotes Hepatocyte
T7916 9995-10019 PR:000008534 denotes Hepatocyte growth factor
T7917 10020-10034 PR:000008534 denotes Scatter factor
T7918 10036-10039 PR:000008534 denotes HGF
T7919 10136-10145 UBERON:0001103 denotes diaphragm
T7920 10170-10173 PR:000008534 denotes HGF
T7921 10177-10186 GO:0010467 denotes expressed
T7922 10198-10206 UBERON:0001062 denotes anatomic
T7923 10225-10229 NCBITaxon:10088 denotes mice
T7924 10250-10253 PR:000008534 denotes HGF
T7925 10263-10268 PR:000010335 denotes c-Met
T7926 10295-10317 UBERON:0009133 denotes pleuroperitoneal folds
T7927 10319-10323 UBERON:0009133 denotes PPFs
T7928 10350-10360 UBERON:0001103 denotes diaphragms
T7929 10370-10374 PR:000017653 denotes Fog2
T7930 10378-10387 GO:0010467 denotes expressed
T7931 10421-10430 UBERON:0001103 denotes diaphragm
T7932 10477-10486 UBERON:0001103 denotes diaphragm
T7933 10511-10515 PR:000012316 denotes Pax3
T7934 10520-10524 PR:000010875 denotes MyoD
T7935 10646-10650 UBERON:0009133 denotes PPFs
T7936 10654-10658 PR:000017653 denotes Fog2
T7937 10663-10667 NCBITaxon:10088 denotes mice
T7938 10703-10713 GO:0010467 denotes expression
T7939 10745-10755 GO:0010467 denotes expression
T7940 10759-10762 PR:000008534 denotes HGF
T7941 10819-10828 UBERON:0001103 denotes diaphragm
T7942 10853-10857 PR:000017653 denotes Fog2
T7943 10865-10869 NCBITaxon:10088 denotes mice
T7944 10902-10906 PR:000017653 denotes Fog2
T7945 10972-10975 PR:000008534 denotes HGF
T7946 10994-11003 UBERON:0001103 denotes diaphragm
T7947 11012-11022 GO:0065007 denotes regulation
T7948 11026-11029 PR:000008534 denotes HGF
T7949 11059-11080 CL:0000680 denotes muscle precursor cell
T7950 11076-11090 GO:0016477 denotes cell migration
T7951 11103-11106 UBERON:0009133 denotes PPF
T7952 11115-11124 UBERON:0001103 denotes diaphragm
T7953 11170-11174 NCBITaxon:10088 denotes mice
T9793 11424-11428 PR:000017653 denotes FOG2
T9794 11456-11465 UBERON:0001103 denotes Diaphragm
T9795 11470-11474 UBERON:0002048 denotes Lung
T9796 11489-11493 PR:000017653 denotes FOG2
T9797 11537-11543 UBERON:0000479 denotes tissue
T9798 11584-11592 UBERON:0001062 denotes anatomic
T9799 11606-11619 UBERON:0001103 denotes diaphragmatic
T9800 11840-11853 UBERON:0001103 denotes diaphragmatic
T9801 11880-11893 UBERON:0001103 denotes diaphragmatic
T9802 12042-12051 UBERON:0002048 denotes Pulmonary
T9803 12082-12086 UBERON:0002048 denotes lung
T9804 12116-12124 UBERON:0003215 denotes alveolar
T9805 12315-12319 PR:000017653 denotes FOG2
T9806 12404-12415 UBERON:0001004 denotes respiratory
T9807 12427-12432 GO:0007567 denotes birth
T9808 12437-12441 GO:0016265 denotes died
T9809 12474-12480 GO:0016265 denotes mortem
T9810 12510-12514 UBERON:0002048 denotes lung
T9811 12535-12540 UBERON:0000160 denotes bowel
T9812 12548-12553 UBERON:0001443 denotes chest
T9813 12650-12659 UBERON:0002048 denotes pulmonary
T9814 12681-12685 UBERON:0002048 denotes lung
T9815 12785-12794 UBERON:0002168 denotes left lung
T9816 12800-12804 UBERON:0002048 denotes lung
T9817 12928-12936 UBERON:0003215 denotes alveolar
T9818 12994-12998 UBERON:0002048 denotes lung
T9819 13038-13051 UBERON:0001103 denotes diaphragmatic
T9820 13125-13136 UBERON:0000211 denotes ligamentous
T9821 13154-13167 UBERON:0001103 denotes diaphragmatic
T9822 13191-13203 _FRAGMENT denotes left lobe of
T9823 13208-13213 UBERON:0001115 denotes liver
T9824 13245-13250 UBERON:0002107 denotes liver
T9825 13291-13300 UBERON:0001103 denotes diaphragm
T9826 13416-13421 UBERON:0000948 denotes heart
T9827 13478-13483 UBERON:0003978 denotes valve
T9828 13565-13569 SO:0000147 denotes exon
T9829 13625-13635 SO:0000319 denotes stop codon
T9830 13723-13730 SO:0000417 denotes domains
T9831 13815-13821 UBERON:0007023 denotes adults
T9832 14090-14094 PR:000017653 denotes FOG2
T5124 3663-3668 GO:0007567 denotes birth
R1800 T7829 T7828 _lexicallyChainedTo Development,Lung
R1801 T7837 T7836 _lexicallyChainedTo development,pulmonary
R2524 T9823 T9822 _lexicallyChainedTo liver,left lobe of

2_test

Id Subject Object Predicate Lexical cue
16103912-11818962-85559735 190-192 11818962 denotes 14
16103912-9457677-85559736 478-480 9457677 denotes 15
16103912-10892744-85559737 4729-4731 10892744 denotes 16
16103912-10892744-85559738 5382-5384 10892744 denotes 16
16103912-10696067-85559739 6662-6664 10696067 denotes 17
16103912-9355800-85559740 6665-6667 9355800 denotes 18
16103912-11063939-85559741 9857-9859 11063939 denotes 19
16103912-10066685-85559742 9860-9862 10066685 denotes 20
16103912-10696067-85559743 9984-9986 10696067 denotes 17
16103912-12388344-85559744 9987-9989 12388344 denotes 21
16103912-10226008-85559745 9990-9992 10226008 denotes 22
16103912-10079225-85559746 10216-10218 10079225 denotes 23
16103912-7651534-85559747 10362-10364 7651534 denotes 24
16103912-8681797-85559748 10365-10367 8681797 denotes 25
16103912-13726619-85559749 12133-12135 13726619 denotes 26
16103912-7065526-85559750 12854-12856 7065526 denotes 28
16103912-7179186-85559751 12967-12969 7179186 denotes 29
T20943 190-192 11818962 denotes 14
T62259 478-480 9457677 denotes 15
T65342 4729-4731 10892744 denotes 16
T5817 5382-5384 10892744 denotes 16
T66232 6662-6664 10696067 denotes 17
T74273 6665-6667 9355800 denotes 18
T90741 9857-9859 11063939 denotes 19
T7030 9860-9862 10066685 denotes 20
T63606 9984-9986 10696067 denotes 17
T80598 9987-9989 12388344 denotes 21
T49937 9990-9992 10226008 denotes 22
T83298 10216-10218 10079225 denotes 23
T51026 10362-10364 7651534 denotes 24
T15263 10365-10367 8681797 denotes 25
T38411 12133-12135 13726619 denotes 26
T80890 12854-12856 7065526 denotes 28
T67813 12967-12969 7179186 denotes 29

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T5179 38-42 UBERON:0002048 denotes lung
T5180 43-51 SO_EXT:sequence_alteration_entity_or_process denotes Mutation
T5181 55-59 PR_EXT:000017653 denotes Fog2
T5182 100-103 CHEBI:23995 denotes ENU
T5183 116-120 NCBITaxon:10088 denotes mice
T5184 124-133 UBERON:0000922 denotes embryonic
T5185 207-211 NCBITaxon:10088 denotes mice
T5186 239-246 UBERON:0000922 denotes embryos
T5187 285-294 UBERON:0002048 denotes pulmonary
T5188 317-326 UBERON:0001103 denotes diaphragm
T5189 332-340 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5190 365-369 UBERON:0002048 denotes lung
T5191 391-401 GO_SO_EXT:chromosome denotes Chromosome
T5192 441-450 SO_EXT:0001024 denotes haplotype
T5193 611-612 SO_EXT:normal_or_wild_type_or_present denotes +
T5194 613-617 NCBITaxon:10088 denotes mice
T5195 647-655 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5196 674-686 SO_EXT:sequence_recombinant_entity denotes recombinants
T5197 755-762 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T5198 881-893 SO_EXT:sequence_recombinant_entity denotes recombinants
T5199 957-965 SO:0000357 denotes flanking
T5200 966-973 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T5201 1035-1044 UBERON:0002048 denotes pulmonary
T5202 1072-1081 UBERON:0001103 denotes diaphragm
T5203 1083-1092 UBERON:0002048 denotes Pulmonary
T5204 1124-1130 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5205 1131-1135 NCBITaxon:10088 denotes mice
T5206 1153-1158 GO:0007567 denotes birth
T5207 1184-1193 SO_EXT:wild_type_entity_or_quality denotes wild-type
T5208 1198-1204 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5209 1205-1209 NCBITaxon:10088 denotes mice
T5210 1235-1239 UBERON:0000104 denotes life
T5211 1241-1245 UBERON_EXT:body denotes body
T5212 1287-1291 UBERON:0002048 denotes lung
T5213 1332-1338 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5214 1339-1343 NCBITaxon:10088 denotes mice
T5215 1357-1363 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5216 1364-1368 UBERON:0002048 denotes lung
T5217 1411-1420 SO_EXT:wild_type_entity_or_quality denotes wild-type
T5218 1421-1425 UBERON:0002048 denotes lung
T5219 1468-1473 UBERON:0002048 denotes lungs
T5220 1479-1485 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5221 1486-1490 NCBITaxon:10088 denotes mice
T5222 1517-1521 UBERON:0009912 denotes lobe
T5223 1594-1598 UBERON:0009912 denotes lobe
T5224 1612-1622 UBERON:0001103 denotes Diaphragms
T5225 1628-1634 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5226 1639-1643 NCBITaxon:10088 denotes mice
T5227 1661-1676 GO_EXT:muscle_structure_or_tissue_development denotes muscularization
T5228 1711-1721 CL:0002372 denotes Myotubules
T5229 1794-1804 CL:0002372 denotes myotubules
T5230 1868-1878 UBERON:0000309 denotes body walls
T5231 1905-1911 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T5232 1905-1918 CL:0000187 denotes muscle fibers
T5233 1926-1943 UBERON:0006670 denotes central tendonous
T5234 1959-1965 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5235 1966-1975 UBERON:0001103 denotes diaphragm
T5236 1977-1987 CL:0002372 denotes myotubules
T5237 2034-2047 UBERON:0002385 denotes muscle tissue
T5238 2087-2097 UBERON:0000309 denotes body walls
T5239 2585-2591 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5240 2592-2596 NCBITaxon:10088 denotes mice
T5241 2614-2619 GO:0007567 denotes birth
T5242 2700-2708 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5243 2744-2753 UBERON:0000922 denotes embryonic
T5244 2823-2830 UBERON:0000995 denotes uterine
T5245 2831-2837 GO:0016265 denotes demise
T5246 2904-2911 UBERON:0000922 denotes embryos
T5247 2963-2970 UBERON:0000995 denotes uterine
T5248 2971-2977 GO:0016265 denotes demise
T5249 2989-2995 GO_EXT:biological_growth_entity_or_process denotes growth
T5250 3021-3027 UBERON:0000479 denotes tissue
T5251 3044-3051 UBERON:0000922 denotes embryos
T5252 3087-3093 GO:0016265 denotes demise
T5253 3172-3180 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5254 3246-3252 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5255 3265-3269 GO:0016265 denotes died
T5256 3305-3311 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5257 3332-3338 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5258 3339-3346 UBERON:0000922 denotes embryos
T5259 3370-3374 GO:0016265 denotes died
T5260 3397-3404 UBERON:0000922 denotes embryos
T5261 3435-3443 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5262 3463-3469 UBERON:0000922 denotes embryo
T5263 3482-3495 UBERON:0001103 denotes Diaphragmatic
T5264 3496-3511 GO_EXT:muscle_structure_or_tissue_development denotes muscularization
T5265 3532-3538 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5266 3539-3543 NCBITaxon:10088 denotes mice
T5267 3563-3572 UBERON:0002048 denotes Pulmonary
T5268 3608-3615 SO_EXT:sequence_altered_entity denotes mutants
T5269 3663-3668 GO:0007567 denotes birth
T5270 3694-3701 UBERON:0000948 denotes cardiac
T5271 3725-3731 UBERON:0000948 denotes hearts
T5272 3747-3753 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5273 3754-3758 NCBITaxon:10088 denotes mice
T5274 3843-3863 UBERON:0002062 denotes endocardial cushions
T5275 3874-3880 UBERON:0004145 denotes outlet
T5276 3881-3896 UBERON:0002080 denotes right ventricle
T5277 3913-3935 UBERON:0002087 denotes atrioventricular canal
T5278 3941-3951 UBERON:0002349 denotes myocardium
T5279 4006-4019 UBERON:0004125 denotes compact layer
T5280 4061-4067 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5281 4068-4072 NCBITaxon:10088 denotes mice
T5282 4090-4095 GO:0007567 denotes birth
T5283 4105-4112 UBERON:0000948 denotes cardiac
T5284 4137-4159 UBERON:0002087 denotes atrioventricular-canal
T5285 4165-4183 UBERON:0002094 denotes ventricular septal
T5286 4193-4206 UBERON:0009149 denotes ostium primum
T5287 4207-4220 UBERON:0002085 denotes atrial septal
T5288 4243-4248 UBERON:0002081 denotes atria
T5289 4271-4278 SO_EXT:sequence_altered_entity denotes mutants
T5290 4308-4315 UBERON:0000948 denotes cardiac
T5291 4348-4355 UBERON:0000948 denotes cardiac
T5292 4348-4367 GO:0007507 denotes cardiac development
T5293 4391-4392 CHEBI_SO_EXT:base denotes b
T5294 4432-4435 CHEBI_SO_EXT:DNA denotes DNA
T5295 4436-4444 SO_EXT:biological_sequence denotes sequence
T5296 4470-4485 SO_EXT:0000996 denotes predicted genes
T5297 4501-4506 SO_EXT:0000704 denotes genes
T5298 4518-4522 PR_EXT:000017653 denotes Fog2
T5299 4533-4542 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T5300 4546-4550 PR_EXT:000017653 denotes Fog2
T5301 4556-4563 UBERON:0000948 denotes cardiac
T5302 4621-4627 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5303 4628-4632 NCBITaxon:10088 denotes mice
T5304 4644-4666 UBERON:0002087 denotes atrioventricular canal
T5305 4684-4694 UBERON:0002349 denotes myocardium
T5306 4707-4715 UBERON:0005985 denotes coronary
T5307 4716-4727 UBERON:0002049 denotes vasculature
T5308 4734-4736 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T5309 4782-4786 PR_EXT:000017653 denotes Fog2
T5310 4803-4814 SO_EXT:0000673 denotes transcripts
T5311 4826-4832 SO_EXT:sequence_altered_entity denotes mutant
T5312 4845-4854 SO_EXT:wild_type_entity_or_quality denotes wild-type
T5313 4855-4862 UBERON:0000922 denotes embryos
T5314 4894-4900 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5315 4901-4911 SO_EXT:0000673 denotes transcript
T5316 4923-4937 SO_EXT:point_mutation_entity_or_process denotes point mutation
T5317 4944-4951 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T5318 4955-4963 CHEBI_EXT:cytosine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes cytosine
T5319 4967-4969 SO_EXT:0000028 denotes bp
T5320 5006-5012 GO:0008380 denotes splice
T5321 5006-5023 SO_EXT:splice_donor denotes splice donor site
T5322 5048-5052 SO_EXT:0000147 denotes exon
T5323 5059-5067 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5324 5077-5085 GO:0008380 denotes splicing
T5325 5113-5122 SO_EXT:sequence_insertion_entity_or_process denotes insertion
T5326 5129-5131 SO_EXT:0000028 denotes bp
T5327 5135-5143 SO_EXT:0000188 denotes intronic
T5328 5144-5152 SO_EXT:biological_sequence denotes sequence
T5329 5162-5168 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5330 5169-5179 SO_EXT:0000673 denotes transcript
T5331 5198-5208 SO_EXT:0000319 denotes stop codon
T5332 5235-5244 SO_EXT:sequence_truncation_process denotes truncated
T5333 5245-5252 CHEBI_PR_EXT:protein denotes protein
T5334 5291-5297 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5335 5298-5302 NCBITaxon:10088 denotes mice
T5336 5323-5327 PR_EXT:000017653 denotes Fog2
T5337 5328-5329 SO_EXT:normal_or_wild_type_or_present denotes +
T5338 5330-5331 SO_EXT:sequence_nullness_or_absence denotes −
T5339 5333-5337 SO_EXT:sequence_nullness denotes null
T5340 5338-5344 SO_EXT:0001023 denotes allele
T5341 5346-5352 SO_EXT:sequence_altered_entity denotes mutant
T5342 5366-5370 SO_EXT:0000704 denotes gene
T5343 5407-5411 NCBITaxon:10088 denotes mice
T5344 5419-5428 UBERON:0000922 denotes embryonic
T5345 5429-5435 GO_EXT:fatality_or_lethality denotes lethal
T5346 5495-5503 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5347 5507-5511 PR_EXT:000017653 denotes Fog2
T5348 5543-5547 NCBITaxon:10088 denotes mice
T5349 5580-5584 PR_EXT:000017653 denotes Fog2
T5350 5585-5589 SO_EXT:sequence_nullness denotes null
T5351 5590-5596 SO_EXT:sequence_altered_entity denotes mutant
T5352 5655-5665 SO_EXT:0000673 denotes transcript
T5353 5694-5700 GO:0008380 denotes splice
T5354 5694-5705 SO_EXT:0000162 denotes splice site
T5355 5706-5714 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T7954 6141-6145 UBERON:0002048 denotes Lung
T7955 6141-6145 _FRAGMENT denotes Lung
T7956 6160-6171 GO:0030324 denotes Development
T7957 6150-6159 UBERON:0001103 denotes Diaphragm
T7958 6150-6171 GO:0060539 denotes Diaphragm Development
T7959 6179-6183 PR_EXT:000017653 denotes Fog2
T7960 6184-6190 SO_EXT:sequence_altered_entity_or_alteration_process denotes Mutant
T7961 6191-6196 NCBITaxon:10088 denotes Mouse
T7962 6248-6252 PR_EXT:000017653 denotes Fog2
T7963 6256-6265 UBERON:0002048 denotes pulmonary
T7964 6256-6265 _FRAGMENT denotes pulmonary
T7965 6284-6295 GO:0030324 denotes development
T7966 6270-6283 UBERON:0001103 denotes diaphragmatic
T7967 6270-6295 GO:0060539 denotes diaphragmatic development
T7968 6301-6310 UBERON:0002048 denotes pulmonary
T7969 6395-6399 UBERON:0009912 denotes lobe
T7970 6434-6438 UBERON:0009912 denotes lobe
T7971 6492-6505 UBERON:0001103 denotes diaphragmatic
T7972 6492-6517 GO:0060539 denotes diaphragmatic development
T7973 6563-6572 UBERON:0002048 denotes pulmonary
T7974 6670-6674 PR_EXT:000017653 denotes Fog2
T7975 6678-6687 GO:0010467 denotes expressed
T7976 6705-6725 UBERON:0004883 denotes pulmonary mesenchyme
T7977 6747-6770 GO:0001763 denotes branching morphogenesis
T7978 6784-6794 GO:0010467 denotes expression
T7979 6816-6830 UBERON:0001135 denotes smooth muscles
T7980 6834-6841 UBERON:0001005 denotes airways
T7981 6846-6855 UBERON:0002048 denotes pulmonary
T7982 6856-6863 UBERON:0000055 denotes vessels
T7983 6907-6912 UBERON:0002048 denotes lungs
T7984 6970-6983 UBERON:0001103 denotes diaphragmatic
T7985 6984-6999 GO_EXT:muscle_structure_or_tissue_development denotes muscularization
T7986 7031-7040 UBERON:0002048 denotes pulmonary
T7987 7080-7093 UBERON:0001103 denotes diaphragmatic
T7988 7127-7132 UBERON:0002048 denotes lungs
T7989 7153-7157 PR_EXT:000017653 denotes Fog2
T7990 7158-7159 SO_EXT:sequence_nullness_or_absence denotes −
T7991 7160-7161 SO_EXT:sequence_nullness_or_absence denotes −
T7992 7162-7166 NCBITaxon:10088 denotes mice
T7993 7217-7230 UBERON:0001103 denotes diaphragmatic
T7994 7231-7237 GO_EXT:biological_movement_or_translocation_process denotes motion
T7995 7239-7243 PR_EXT:000017653 denotes Fog2
T7996 7244-7245 SO_EXT:sequence_nullness_or_absence denotes −
T7997 7246-7247 SO_EXT:sequence_nullness_or_absence denotes −
T7998 7248-7252 NCBITaxon:10088 denotes mice
T7999 7361-7369 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T8000 7371-7376 UBERON:0002048 denotes Lungs
T8001 7399-7403 PR_EXT:000017653 denotes Fog2
T8002 7404-7405 SO_EXT:sequence_nullness_or_absence denotes −
T8003 7406-7407 SO_EXT:sequence_nullness_or_absence denotes −
T8004 7408-7415 UBERON:0000922 denotes embryos
T8005 7480-7484 UBERON:0009912 denotes lobe
T8006 7499-7503 PR_EXT:000017653 denotes Fog2
T8007 7503-7504 SO_EXT:sequence_nullness_or_absence denotes −
T8008 7506-7507 SO_EXT:sequence_nullness_or_absence denotes −
T8010 7575-7579 UBERON:0009912 denotes lobe
T8011 7600-7606 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T8012 7607-7612 UBERON:0002048 denotes lungs
T8013 7733-7742 UBERON:0002048 denotes pulmonary
T8014 7757-7761 PR_EXT:000017653 denotes Fog2
T8015 7762-7768 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T8016 7769-7773 NCBITaxon:10088 denotes mice
T8017 8435-8440 UBERON:0009912 denotes lobes
T8018 8483-8490 SO_EXT:sequence_altered_entity denotes mutants
T8019 8550-8555 UBERON:0009912 denotes lobes
T8020 8591-8595 PR_EXT:000017653 denotes Fog2
T8021 8631-8636 UBERON:0009912 denotes lobar
T8022 8666-8670 PR_EXT:000017653 denotes Fog2
T8023 8671-8681 GO:0010467 denotes expression
T8024 8706-8713 UBERON:0000922 denotes embryos
T8025 8741-8746 UBERON:0009912 denotes lobar
T8026 8782-8786 PR_EXT:000017653 denotes Fog2
T8027 8787-8797 GO:0010467 denotes expression
T8028 8833-8838 UBERON:0009912 denotes lobar
T8029 8845-8855 GO:0010467 denotes Expression
T8030 8873-8877 NCBITaxon:10088 denotes mice
T8031 8889-8893 PR_EXT:000033987 denotes lacZ
T8032 8894-8898 SO_EXT:0000704 denotes gene
T8033 8921-8925 PR_EXT:000017653 denotes Fog2
T8034 8973-8977 NCBITaxon:10088 denotes mice
T8035 9001-9006 UBERON:0002048 denotes lungs
T8036 9040-9044 PR_EXT:000017653 denotes Fog2
T8037 9045-9055 GO:0010467 denotes expression
T8038 9063-9073 UBERON:0003104 denotes mesenchyme
T8039 9125-9129 UBERON:0009912 denotes lobe
T8040 9149-9154 UBERON:0009912 denotes lobes
T8041 9187-9191 PR_EXT:000017653 denotes Fog2
T8042 9192-9198 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T8043 9199-9203 NCBITaxon:10088 denotes mice
T8044 9226-9236 GO:0010467 denotes expression
T8045 9256-9276 UBERON:0004883 denotes pulmonary mesenchyme
T8046 9314-9327 GO:0097617 denotes hybridization
T8047 9331-9337 UBERON:0000479 denotes tissue
T8048 9622-9632 UBERON:0001103 denotes Diaphragms
T8049 9638-9642 PR_EXT:000017653 denotes Fog2
T8050 9647-9651 NCBITaxon:10088 denotes mice
T8051 9693-9701 UBERON_EXT:muscle_structure_or_tissue denotes muscular
T8052 9702-9712 GO_PATO_EXT:biological_patterning_process_or_quality denotes patterning
T8053 9760-9769 UBERON:0001103 denotes diaphragm
T8054 9788-9797 GO_EXT:biological_movement_or_translocation_process denotes migratory
T8055 9798-9811 _FRAGMENT denotes population of
T8056 9829-9834 UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population denotes cells
T8057 9812-9818 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T8058 9812-9834 CL:0000680 denotes muscle precursor cells
T8059 9829-9834 CL_GO_EXT:cell denotes cells
T8060 9850-9855 UBERON:0002101 denotes limbs
T8061 9865-9869 NCBITaxon:10088 denotes Mice
T8062 9886-9891 SO_EXT:0000704 denotes genes
T8063 9922-9929 GO:0065007 denotes control
T8064 9963-9971 UBERON_EXT:muscle_structure_or_tissue denotes muscular
T8065 9972-9982 UBERON:0001103 denotes diaphragms
T8066 9995-10005 CL:0000182 denotes Hepatocyte
T8067 9995-10019 PR_EXT:000008534 denotes Hepatocyte growth factor
T8068 10006-10012 GO_EXT:biological_growth_entity_or_process denotes growth
T8069 10006-10019 GO_EXT:0008083 denotes growth factor
T8070 10020-10034 PR_EXT:000008534 denotes Scatter factor
T8071 10036-10039 PR_EXT:000008534 denotes HGF
T8072 10088-10096 GO_EXT:biological_direction_or_guidance denotes guidance
T8073 10100-10106 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T8074 10136-10145 UBERON:0001103 denotes diaphragm
T8075 10170-10173 PR_EXT:000008534 denotes HGF
T8076 10177-10186 GO:0010467 denotes expressed
T8077 10198-10206 UBERON:0001062 denotes anatomic
T8078 10225-10229 NCBITaxon:10088 denotes mice
T8079 10250-10262 GO_PR_EXT:hepatocyte_growth_factor_receptor denotes HGF receptor
T8080 10263-10268 PR_EXT:000010335 denotes c-Met
T8081 10282-10294 GO_EXT:muscle_structure_or_tissue_development denotes muscularized
T8082 10295-10317 UBERON:0009133 denotes pleuroperitoneal folds
T8083 10319-10323 UBERON:0009133 denotes PPFs
T8084 10341-10349 UBERON_EXT:muscle_structure_or_tissue denotes muscular
T8085 10350-10360 UBERON:0001103 denotes diaphragms
T8086 10370-10374 PR_EXT:000017653 denotes Fog2
T8087 10378-10387 GO:0010467 denotes expressed
T8088 10412-10420 UBERON_EXT:muscle_structure_or_tissue denotes muscular
T8089 10421-10430 UBERON:0001103 denotes diaphragm
T8090 10464-10476 GO_EXT:muscle_structure_or_tissue_development denotes muscularized
T8091 10477-10486 UBERON:0001103 denotes diaphragm
T8092 10511-10515 PR_EXT:000012316 denotes Pax3
T8093 10520-10524 PR_EXT:000010875 denotes MyoD
T8094 10526-10539 GO_EXT:transcription denotes transcription
T8095 10526-10547 GO_EXT:transcription_factor denotes transcription factors
T8096 10573-10582 GO_EXT:biological_movement_or_translocation_process denotes migration
T8097 10604-10612 GO_EXT:muscle_structure_or_tissue_development denotes myogenic
T8098 10646-10650 UBERON:0009133 denotes PPFs
T8099 10654-10658 PR_EXT:000017653 denotes Fog2
T8100 10663-10667 NCBITaxon:10088 denotes mice
T8101 10703-10713 GO:0010467 denotes expression
T8102 10745-10755 GO:0010467 denotes expression
T8103 10759-10762 PR_EXT:000008534 denotes HGF
T8104 10819-10828 UBERON:0001103 denotes diaphragm
T8105 10853-10857 PR_EXT:000017653 denotes Fog2
T8106 10858-10864 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T8107 10865-10869 NCBITaxon:10088 denotes mice
T8108 10902-10906 PR_EXT:000017653 denotes Fog2
T8109 10972-10975 PR_EXT:000008534 denotes HGF
T8110 10994-11003 UBERON:0001103 denotes diaphragm
T8111 11012-11022 GO:0065007 denotes regulation
T8112 11026-11029 PR_EXT:000008534 denotes HGF
T8113 11030-11040 GO_PATO_EXT:biological_patterning_process_or_quality denotes patterning
T8114 11059-11065 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T8115 11059-11080 CL:0000680 denotes muscle precursor cell
T8116 11076-11080 CL_GO_EXT:cell denotes cell
T8117 11076-11090 GO:0016477 denotes cell migration
T8118 11103-11106 UBERON:0009133 denotes PPF
T8119 11115-11124 UBERON:0001103 denotes diaphragm
T8120 11170-11174 NCBITaxon:10088 denotes mice
T9833 11424-11428 PR_EXT:000017653 denotes FOG2
T9834 11429-11437 SO_EXT:sequence_alteration_entity_or_process denotes Mutation
T9835 11456-11465 UBERON:0001103 denotes Diaphragm
T9836 11470-11474 UBERON:0002048 denotes Lung
T9837 11489-11493 PR_EXT:000017653 denotes FOG2
T9838 11494-11502 SO_EXT:biological_sequence denotes sequence
T9839 11537-11543 UBERON:0000479 denotes tissue
T9840 11567-11575 NCBITaxon_UBERON_EXT:child denotes children
T9841 11584-11592 UBERON:0001062 denotes anatomic
T9842 11606-11619 UBERON:0001103 denotes diaphragmatic
T9843 11644-11652 NCBITaxon_UBERON_EXT:child denotes Children
T9844 11840-11853 UBERON:0001103 denotes diaphragmatic
T9845 11880-11893 UBERON:0001103 denotes diaphragmatic
T9846 11906-11921 GO_EXT:muscle_structure_or_tissue_development denotes muscularization
T9847 12042-12051 UBERON:0002048 denotes Pulmonary
T9848 12082-12086 UBERON:0002048 denotes lung
T9849 12087-12091 UBERON_EXT:body denotes body
T9850 12116-12124 UBERON:0003215 denotes alveolar
T9851 12280-12285 NCBITaxon_UBERON_EXT:child denotes child
T9852 12315-12319 PR_EXT:000017653 denotes FOG2
T9853 12320-12328 SO_EXT:biological_sequence denotes sequence
T9854 12329-12335 SO_EXT:sequence_alteration_entity_or_process denotes change
T9855 12373-12377 UBERON_EXT:baby_or_infant denotes baby
T9856 12378-12382 NCBITaxon_UBERON_EXT:girl denotes girl
T9857 12404-12415 UBERON:0001004 denotes respiratory
T9858 12427-12432 GO:0007567 denotes birth
T9859 12437-12441 GO:0016265 denotes died
T9860 12474-12480 GO:0016265 denotes mortem
T9861 12510-12514 UBERON:0002048 denotes lung
T9862 12535-12540 UBERON:0000160 denotes bowel
T9863 12548-12553 UBERON:0001443 denotes chest
T9864 12650-12659 UBERON:0002048 denotes pulmonary
T9865 12681-12685 UBERON:0002048 denotes lung
T9866 12715-12719 UBERON_EXT:body denotes body
T9867 12785-12794 UBERON:0002168 denotes left lung
T9868 12800-12804 UBERON:0002048 denotes lung
T9869 12805-12809 UBERON_EXT:body denotes body
T9870 12890-12899 UBERON_EXT:bronchiole_or_bronchus denotes bronchial
T9871 12928-12936 UBERON:0003215 denotes alveolar
T9872 12994-12998 UBERON:0002048 denotes lung
T9873 13038-13051 UBERON:0001103 denotes diaphragmatic
T9874 13112-13124 GO_EXT:muscle_structure_or_tissue_development denotes muscularized
T9875 13125-13136 UBERON:0000211 denotes ligamentous
T9876 13154-13167 UBERON:0001103 denotes diaphragmatic
T9877 13191-13203 _FRAGMENT denotes left lobe of
T9878 13208-13213 UBERON:0001115 denotes liver
T9879 13245-13250 UBERON:0002107 denotes liver
T9880 13291-13300 UBERON:0001103 denotes diaphragm
T9881 13315-13327 GO_EXT:muscle_structure_or_tissue_development denotes muscularized
T9882 13416-13421 UBERON:0000948 denotes heart
T9883 13478-13483 UBERON:0003978 denotes valve
T9884 13493-13501 SO_EXT:biological_sequence denotes Sequence
T9885 13522-13530 CHEBI_EXT:cytosine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes cytosine
T9886 13534-13541 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T9887 13555-13561 SO_EXT:sequence_alteration_entity_or_process denotes change
T9888 13565-13569 SO_EXT:0000147 denotes exon
T9889 13577-13584 SO_EXT:sequence_alteration_process denotes changes
T9890 13595-13605 CHEBI_SO_EXT:amino_acid denotes amino acid
T9891 13611-13619 CHEBI_SO_EXT:arginine denotes arginine
T9892 13625-13635 SO_EXT:0000319 denotes stop codon
T9893 13642-13650 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T9894 13671-13680 SO_EXT:sequence_truncation_process denotes truncated
T9895 13681-13688 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptide
T9896 13711-13715 CHEBI_EXT:zinc denotes zinc
T9897 13723-13730 SO_EXT:0000417 denotes domains
T9898 13748-13752 CHEBI_SO_EXT:base denotes base
T9899 13753-13759 SO_EXT:sequence_alteration_entity_or_process denotes change
T9900 13795-13798 CHEBI_SO_EXT:DNA denotes DNA
T9901 13815-13821 UBERON:0007023 denotes adults
T9902 13857-13865 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T9903 13965-13973 SO_EXT:biological_sequence denotes sequence
T9904 14029-14037 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T9905 14078-14086 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T9906 14090-14094 PR_EXT:000017653 denotes FOG2
T8009 7508-7512 UBERON:0002048 denotes lung
R1802 T7956 T7955 _lexicallyChainedTo Development,Lung
R1803 T7965 T7964 _lexicallyChainedTo development,pulmonary
R1804 T8056 T8055 _lexicallyChainedTo cells,population of
R2525 T9878 T9877 _lexicallyChainedTo liver,left lobe of

craft-sa-dev

Id Subject Object Predicate Lexical cue
T5761 2061-2064 DT denotes the
T5762 2072-2079 NN denotes surface
T5763 2065-2071 JJ denotes entire
T5764 2080-2082 IN denotes of
T5765 2083-2086 DT denotes the
T5766 2092-2097 NNS denotes walls
T5767 2087-2091 NN denotes body
T5768 2098-2099 -LRB- denotes (
T5769 2099-2105 NN denotes Figure
T5770 2106-2108 CD denotes 1B
T5771 2108-2109 -RRB- denotes )
T5772 2109-2110 . denotes .
T5773 2110-2709 sentence denotes Figure 1 Abnormal Pulmonary and Diaphragmatic Development in the lil Mouse (A) The mutant hypoplastic lung (right) lacks the development of the accessory lobe and the anterior portion of the right middle lobe (marked with arrows on the control sample on the left). (B) Whole diaphragms show a lack of normal muscularization in the posterolateral regions and the peripheral regions of the mutant diaphragm (control on left and lil diaphragm on the right). The number of lil mutant mice that survived to birth was less than 5% of total progeny, rather than the 25% expected for a recessive mutation.
T5774 2567-2570 DT denotes The
T5775 2571-2577 NN denotes number
T5776 2620-2623 VBD denotes was
T5777 2578-2580 IN denotes of
T5778 2581-2584 NN denotes lil
T5779 2592-2596 NNS denotes mice
T5780 2585-2591 NN denotes mutant
T5781 2597-2601 WDT denotes that
T5782 2602-2610 VBD denotes survived
T5783 2611-2613 IN denotes to
T5784 2614-2619 NN denotes birth
T5785 2624-2628 JJR denotes less
T5786 2634-2635 CD denotes 5
T5787 2629-2633 IN denotes than
T5788 2635-2636 NN denotes %
T5789 2637-2639 IN denotes of
T5790 2640-2645 JJ denotes total
T5791 2646-2653 NN denotes progeny
T5792 2653-2655 , denotes ,
T5793 2655-2661 RB denotes rather
T5794 2662-2666 IN denotes than
T5795 2667-2670 DT denotes the
T5796 2673-2674 NN denotes %
T5797 2671-2673 CD denotes 25
T5798 2675-2683 VBN denotes expected
T5799 2684-2687 IN denotes for
T5800 2688-2689 DT denotes a
T5801 2700-2708 NN denotes mutation
T5802 2690-2699 JJ denotes recessive
T5803 2708-2709 . denotes .
T5804 2709-2838 sentence denotes We evaluated litters at different embryonic time points to determine whether the reduced number was due to intra-uterine demise.
T5805 2710-2712 PRP denotes We
T5806 2713-2722 VBD denotes evaluated
T5807 2723-2730 NNS denotes litters
T5808 2731-2733 IN denotes at
T5809 2734-2743 JJ denotes different
T5810 2759-2765 NNS denotes points
T5811 2744-2753 JJ denotes embryonic
T5812 2754-2758 NN denotes time
T5813 2766-2768 TO denotes to
T5814 2769-2778 VB denotes determine
T5815 2779-2786 IN denotes whether
T5816 2806-2809 VBD denotes was
T5817 2787-2790 DT denotes the
T5818 2799-2805 NN denotes number
T5819 2791-2798 VBN denotes reduced
T5820 2810-2813 IN denotes due
T5821 2814-2816 IN denotes to
T5822 2817-2830 JJ denotes intra-uterine
T5823 2831-2837 NN denotes demise
T5824 2837-2838 . denotes .
T5825 2838-3039 sentence denotes Litters were collected at E12.5, 13.5, 15.5, 17.5, and 18.5, and embryos were genotyped and evaluated for evidence of intra-uterine demise, including growth retardation, pallor, and tissue friability.
T5826 2839-2846 NNS denotes Litters
T5827 2852-2861 VBN denotes collected
T5828 2847-2851 VBD denotes were
T5829 2862-2864 IN denotes at
T5830 2865-2870 NN denotes E12.5
T5831 2870-2872 , denotes ,
T5832 2872-2876 CD denotes 13.5
T5833 2876-2878 , denotes ,
T5834 2878-2882 CD denotes 15.5
T5835 2882-2884 , denotes ,
T5836 2884-2888 CD denotes 17.5
T5837 2888-2890 , denotes ,
T5838 2890-2893 CC denotes and
T5839 2894-2898 CD denotes 18.5
T5840 2898-2900 , denotes ,
T5841 2900-2903 CC denotes and
T5842 2904-2911 NNS denotes embryos
T5843 2917-2926 VBN denotes genotyped
T5844 2912-2916 VBD denotes were
T5845 2927-2930 CC denotes and
T5846 2931-2940 VBN denotes evaluated
T5847 2941-2944 IN denotes for
T5848 2945-2953 NN denotes evidence
T5849 2954-2956 IN denotes of
T5850 2957-2970 JJ denotes intra-uterine
T5851 2971-2977 NN denotes demise
T5852 2977-2979 , denotes ,
T5853 2979-2988 VBG denotes including
T5854 2989-2995 NN denotes growth
T5855 2996-3007 NN denotes retardation
T5856 3007-3009 , denotes ,
T5857 3009-3015 NN denotes pallor
T5858 3015-3017 , denotes ,
T5859 3017-3020 CC denotes and
T5860 3021-3027 NN denotes tissue
T5861 3028-3038 NN denotes friability
T5862 3038-3039 . denotes .
T5863 3039-3118 sentence denotes lil embryos had a progressively higher rate of demise between E13.5 and E15.5.
T5864 3040-3043 NN denotes lil
T5865 3044-3051 NNS denotes embryos
T5866 3052-3055 VBD denotes had
T5867 3056-3057 DT denotes a
T5868 3079-3083 NN denotes rate
T5356 9-23 NN denotes Identification
T5357 24-26 IN denotes of
T5358 27-30 DT denotes the
T5359 43-51 NN denotes Mutation
T5360 31-37 JJ denotes little
T5361 38-42 NN denotes lung
T5362 52-54 IN denotes in
T5363 55-59 NN denotes Fog2
T5364 59-194 sentence denotes We screened third-generation progeny of ENU-mutagenized mice at embryonic day 18.5 (E18.5) for abnormal developmental phenotypes [14].
T5365 60-62 PRP denotes We
T5366 63-71 VBD denotes screened
T5367 72-77 JJ denotes third
T5368 78-88 NN denotes generation
T5369 77-78 HYPH denotes -
T5370 89-96 NN denotes progeny
T5371 97-99 IN denotes of
T5372 100-103 NN denotes ENU
T5373 104-115 VBN denotes mutagenized
T5374 103-104 HYPH denotes -
T5375 116-120 NNS denotes mice
T5376 121-123 IN denotes at
T5377 124-133 JJ denotes embryonic
T5378 134-137 NN denotes day
T5379 138-142 CD denotes 18.5
T5380 143-144 -LRB- denotes (
T5381 144-149 NN denotes E18.5
T5382 149-150 -RRB- denotes )
T5383 151-154 IN denotes for
T5384 155-163 JJ denotes abnormal
T5385 178-188 NNS denotes phenotypes
T5386 164-177 JJ denotes developmental
T5387 189-190 -LRB- denotes [
T5388 190-192 CD denotes 14
T5389 192-193 -RRB- denotes ]
T5390 193-194 . denotes .
T5391 194-327 sentence denotes One line of mice was found to have multiple embryos in independent litters that displayed pulmonary hypoplasia and a thin diaphragm.
T5392 195-198 CD denotes One
T5393 199-203 NN denotes line
T5394 216-221 VBN denotes found
T5395 204-206 IN denotes of
T5396 207-211 NNS denotes mice
T5397 212-215 VBD denotes was
T5398 222-224 TO denotes to
T5399 225-229 VB denotes have
T5400 230-238 JJ denotes multiple
T5401 239-246 NNS denotes embryos
T5402 247-249 IN denotes in
T5403 250-261 JJ denotes independent
T5404 262-269 NNS denotes litters
T5405 270-274 WDT denotes that
T5406 275-284 VBD denotes displayed
T5407 285-294 JJ denotes pulmonary
T5408 295-305 NN denotes hypoplasia
T5409 306-309 CC denotes and
T5410 310-311 DT denotes a
T5411 317-326 NN denotes diaphragm
T5412 312-316 JJ denotes thin
T5413 326-327 . denotes .
T5414 327-482 sentence denotes The mutation, which we called little lung (lil), was mapped to Chromosome 15 by utilizing a strategy of interval haplotype analysis (data not shown) [15].
T5415 328-331 DT denotes The
T5416 332-340 NN denotes mutation
T5417 381-387 VBN denotes mapped
T5418 340-342 , denotes ,
T5419 342-347 WDT denotes which
T5420 351-357 VBD denotes called
T5421 348-350 PRP denotes we
T5422 358-364 JJ denotes little
T5423 365-369 NN denotes lung
T5424 370-371 -LRB- denotes (
T5425 371-374 NN denotes lil
T5426 374-375 -RRB- denotes )
T5427 375-377 , denotes ,
T5428 377-380 VBD denotes was
T5429 388-390 IN denotes to
T5430 391-401 NN denotes Chromosome
T5431 402-404 CD denotes 15
T5432 405-407 IN denotes by
T5433 408-417 VBG denotes utilizing
T5434 418-419 DT denotes a
T5435 420-428 NN denotes strategy
T5436 429-431 IN denotes of
T5437 432-440 JJ denotes interval
T5438 451-459 NN denotes analysis
T5439 441-450 NN denotes haplotype
T5440 460-461 -LRB- denotes (
T5441 470-475 VBN denotes shown
T5442 461-465 NNS denotes data
T5443 466-469 RB denotes not
T5444 475-476 -RRB- denotes )
T5445 477-478 -LRB- denotes [
T5446 478-480 CD denotes 15
T5447 480-481 -RRB- denotes ]
T5448 481-482 . denotes .
T5449 482-554 sentence denotes For high-resolution mapping, F2 progeny from two crosses were analyzed.
T5450 483-486 IN denotes For
T5451 545-553 VBN denotes analyzed
T5452 487-491 JJ denotes high
T5453 492-502 NN denotes resolution
T5454 491-492 HYPH denotes -
T5455 503-510 NN denotes mapping
T5456 510-512 , denotes ,
T5457 512-514 NN denotes F2
T5458 515-522 NN denotes progeny
T5459 523-527 IN denotes from
T5460 528-531 CD denotes two
T5461 532-539 NNS denotes crosses
T5462 540-544 VBD denotes were
T5463 553-554 . denotes .
T5464 554-719 sentence denotes In 450 progeny of an intercross of F1 (A/J × FVB/N) lil/+ mice, the interval containing the mutation was defined by 19 recombinants between D15Mit220 and D15Mit154.
T5465 555-557 IN denotes In
T5466 660-667 VBN denotes defined
T5467 558-561 CD denotes 450
T5468 562-569 NN denotes progeny
T5469 570-572 IN denotes of
T5470 573-575 DT denotes an
T5471 576-586 NN denotes intercross
T5472 587-589 IN denotes of
T5473 590-592 NN denotes F1
T5474 613-617 NNS denotes mice
T5475 593-594 -LRB- denotes (
T5476 596-597 NN denotes J
T5477 594-595 NN denotes A
T5478 595-596 SYM denotes /
T5479 598-599 SYM denotes ×
T5480 600-603 NN denotes FVB
T5481 604-605 NN denotes N
T5482 603-604 HYPH denotes /
T5483 605-606 -RRB- denotes )
T5484 607-610 NN denotes lil
T5485 610-611 HYPH denotes /
T5486 611-612 SYM denotes +
T5487 617-619 , denotes ,
T5488 619-622 DT denotes the
T5489 623-631 NN denotes interval
T5490 632-642 VBG denotes containing
T5491 643-646 DT denotes the
T5492 647-655 NN denotes mutation
T5493 656-659 VBD denotes was
T5494 668-670 IN denotes by
T5495 671-673 CD denotes 19
T5496 674-686 NNS denotes recombinants
T5497 687-694 IN denotes between
T5498 695-704 NN denotes D15Mit220
T5499 705-708 CC denotes and
T5500 709-718 NN denotes D15Mit154
T5501 718-719 . denotes .
T5502 719-854 sentence denotes Because of the lack of informative markers within this interval, an additional 39 F2 progeny from an A/J × C57BL/6J cross were tested.
T5503 720-727 IN denotes Because
T5504 847-853 VBN denotes tested
T5505 728-730 IN denotes of
T5506 731-734 DT denotes the
T5507 735-739 NN denotes lack
T5508 740-742 IN denotes of
T5509 743-754 JJ denotes informative
T5510 755-762 NNS denotes markers
T5511 763-769 IN denotes within
T5512 770-774 DT denotes this
T5513 775-783 NN denotes interval
T5514 783-785 , denotes ,
T5515 785-787 DT denotes an
T5516 799-801 CD denotes 39
T5517 788-798 JJ denotes additional
T5518 805-812 NN denotes progeny
T5519 802-804 NN denotes F2
T5520 813-817 IN denotes from
T5521 818-820 DT denotes an
T5522 836-841 NN denotes cross
T5523 821-822 NN denotes A
T5524 823-824 NN denotes J
T5525 822-823 HYPH denotes /
T5526 825-826 SYM denotes ×
T5527 827-832 NN denotes C57BL
T5528 833-835 NN denotes 6J
T5529 832-833 HYPH denotes /
T5530 842-846 VBD denotes were
T5531 853-854 . denotes .
T5532 854-974 sentence denotes The identification of two recombinants established D15Mit85 as the proximal and D15Mit5 as the distal flanking markers.
T5533 855-858 DT denotes The
T5534 859-873 NN denotes identification
T5535 894-905 VBD denotes established
T5536 874-876 IN denotes of
T5537 877-880 CD denotes two
T5538 881-893 NNS denotes recombinants
T5539 906-914 NN denotes D15Mit85
T5540 915-917 IN denotes as
T5541 918-921 DT denotes the
T5542 922-930 JJ denotes proximal
T5543 931-934 CC denotes and
T5544 935-942 NN denotes D15Mit5
T5545 943-945 IN denotes as
T5546 946-949 DT denotes the
T5547 950-956 JJ denotes distal
T5548 957-965 NN denotes flanking
T5549 966-973 NNS denotes markers
T5550 973-974 . denotes .
T5551 974-1082 sentence denotes The lil phenotype was identified at E18.5 to have bilateral pulmonary hypoplasia and an abnormal diaphragm.
T5552 975-978 DT denotes The
T5553 983-992 NN denotes phenotype
T5554 979-982 NN denotes lil
T5555 997-1007 VBN denotes identified
T5556 993-996 VBD denotes was
T5557 1008-1010 IN denotes at
T5558 1011-1016 NN denotes E18.5
T5559 1017-1019 TO denotes to
T5560 1020-1024 VB denotes have
T5561 1025-1034 JJ denotes bilateral
T5562 1045-1055 NN denotes hypoplasia
T5563 1035-1044 JJ denotes pulmonary
T5564 1056-1059 CC denotes and
T5565 1060-1062 DT denotes an
T5566 1072-1081 NN denotes diaphragm
T5567 1063-1071 JJ denotes abnormal
T5568 1081-1082 . denotes .
T5569 1082-1159 sentence denotes Pulmonary hypoplasia was apparent in all mutant mice that survived to birth.
T5570 1083-1092 JJ denotes Pulmonary
T5571 1093-1103 NN denotes hypoplasia
T5572 1104-1107 VBD denotes was
T5573 1108-1116 JJ denotes apparent
T5574 1117-1119 IN denotes in
T5575 1120-1123 DT denotes all
T5576 1131-1135 NNS denotes mice
T5577 1124-1130 NN denotes mutant
T5578 1136-1140 WDT denotes that
T5579 1141-1149 VBD denotes survived
T5580 1150-1152 IN denotes to
T5581 1153-1158 NN denotes birth
T5582 1158-1159 . denotes .
T5583 1159-1344 sentence denotes In a comparison between wild-type and mutant mice found dead on day one of life, body weights were not different; however, the lung weights were significantly lower in the mutant mice.
T5584 1160-1162 IN denotes In
T5585 1300-1304 VBD denotes were
T5586 1163-1164 DT denotes a
T5587 1165-1175 NN denotes comparison
T5588 1176-1183 IN denotes between
T5589 1184-1188 JJ denotes wild
T5590 1189-1193 NN denotes type
T5591 1188-1189 HYPH denotes -
T5592 1205-1209 NNS denotes mice
T5593 1194-1197 CC denotes and
T5594 1198-1204 NN denotes mutant
T5595 1210-1215 VBN denotes found
T5596 1216-1220 JJ denotes dead
T5597 1221-1223 IN denotes on
T5598 1224-1227 NN denotes day
T5599 1228-1231 CD denotes one
T5600 1232-1234 IN denotes of
T5601 1235-1239 NN denotes life
T5602 1239-1241 , denotes ,
T5603 1241-1245 NN denotes body
T5604 1246-1253 NNS denotes weights
T5605 1254-1258 VBD denotes were
T5606 1259-1262 RB denotes not
T5607 1263-1272 JJ denotes different
T5608 1272-1273 : denotes ;
T5609 1274-1281 RB denotes however
T5610 1281-1283 , denotes ,
T5611 1283-1286 DT denotes the
T5612 1292-1299 NNS denotes weights
T5613 1287-1291 NN denotes lung
T5614 1305-1318 RB denotes significantly
T5615 1319-1324 JJR denotes lower
T5616 1325-1327 IN denotes in
T5617 1328-1331 DT denotes the
T5618 1339-1343 NNS denotes mice
T5619 1332-1338 NN denotes mutant
T5620 1343-1344 . denotes .
T5621 1344-1463 sentence denotes The average mutant lung weight was 9.6 ± 2.5 mg while the average wild-type lung weight was 26.4 ± 4.6 mg (p < 0.001).
T5622 1345-1348 DT denotes The
T5623 1369-1375 NN denotes weight
T5624 1349-1356 JJ denotes average
T5625 1357-1363 NN denotes mutant
T5626 1364-1368 NN denotes lung
T5627 1376-1379 VBD denotes was
T5628 1380-1383 CD denotes 9.6
T5629 1386-1389 CD denotes 2.5
T5630 1384-1385 SYM denotes ±
T5631 1390-1392 NN denotes mg
T5632 1393-1398 IN denotes while
T5633 1433-1436 VBD denotes was
T5634 1399-1402 DT denotes the
T5635 1426-1432 NN denotes weight
T5636 1403-1410 JJ denotes average
T5637 1411-1415 JJ denotes wild
T5638 1416-1420 NN denotes type
T5639 1415-1416 HYPH denotes -
T5640 1421-1425 NN denotes lung
T5641 1437-1441 CD denotes 26.4
T5642 1444-1447 CD denotes 4.6
T5643 1442-1443 SYM denotes ±
T5644 1448-1450 NN denotes mg
T5645 1451-1452 -LRB- denotes (
T5646 1456-1461 CD denotes 0.001
T5647 1452-1453 NN denotes p
T5648 1454-1455 SYM denotes <
T5649 1461-1462 -RRB- denotes )
T5650 1462-1463 . denotes .
T5651 1463-1611 sentence denotes All lungs from mutant mice were lacking an accessory lobe on the right side and had underdevelopment of the anterior right middle lobe (Figure 1A).
T5652 1464-1467 DT denotes All
T5653 1468-1473 NNS denotes lungs
T5654 1496-1503 VBG denotes lacking
T5655 1474-1478 IN denotes from
T5656 1479-1485 NN denotes mutant
T5657 1486-1490 NNS denotes mice
T5658 1491-1495 VBD denotes were
T5659 1504-1506 DT denotes an
T5660 1517-1521 NN denotes lobe
T5661 1507-1516 JJ denotes accessory
T5662 1522-1524 IN denotes on
T5663 1525-1528 DT denotes the
T5664 1535-1539 NN denotes side
T5665 1529-1534 JJ denotes right
T5666 1540-1543 CC denotes and
T5667 1544-1547 VBD denotes had
T5668 1548-1564 NN denotes underdevelopment
T5669 1565-1567 IN denotes of
T5670 1568-1571 DT denotes the
T5671 1594-1598 NN denotes lobe
T5672 1572-1580 JJ denotes anterior
T5673 1581-1586 JJ denotes right
T5674 1587-1593 JJ denotes middle
T5675 1599-1600 -LRB- denotes (
T5676 1600-1606 NN denotes Figure
T5677 1607-1609 CD denotes 1A
T5678 1609-1610 -RRB- denotes )
T5679 1610-1611 . denotes .
T5680 1611-1710 sentence denotes Diaphragms from mutant lil mice were intact, but muscularization was absent in the dorsal regions.
T5681 1612-1622 NNS denotes Diaphragms
T5682 1644-1648 VBD denotes were
T5683 1623-1627 IN denotes from
T5684 1628-1634 NN denotes mutant
T5685 1639-1643 NNS denotes mice
T5686 1635-1638 NN denotes lil
T5687 1649-1655 JJ denotes intact
T5688 1655-1657 , denotes ,
T5689 1657-1660 CC denotes but
T5690 1661-1676 NN denotes muscularization
T5691 1677-1680 VBD denotes was
T5692 1681-1687 JJ denotes absent
T5693 1688-1690 IN denotes in
T5694 1691-1694 DT denotes the
T5695 1702-1709 NNS denotes regions
T5696 1695-1701 JJ denotes dorsal
T5697 1709-1710 . denotes .
T5698 1710-1774 sentence denotes Myotubules were present in a limited and abnormal distribution.
T5699 1711-1721 NNS denotes Myotubules
T5700 1722-1726 VBD denotes were
T5701 1727-1734 JJ denotes present
T5702 1735-1737 IN denotes in
T5703 1738-1739 DT denotes a
T5704 1761-1773 NN denotes distribution
T5705 1740-1747 JJ denotes limited
T5706 1748-1751 CC denotes and
T5707 1752-1760 JJ denotes abnormal
T5708 1773-1774 . denotes .
T5709 1774-1951 sentence denotes More specifically, myotubules normally radiate in a mediolateral fashion to meet the lateral body walls, with a normal paucity of muscle fibers in the central tendonous region.
T5710 1775-1779 RBR denotes More
T5711 1780-1792 RB denotes specifically
T5712 1814-1821 VBP denotes radiate
T5713 1792-1794 , denotes ,
T5714 1794-1804 NNS denotes myotubules
T5715 1805-1813 RB denotes normally
T5716 1822-1824 IN denotes in
T5717 1825-1826 DT denotes a
T5718 1840-1847 NN denotes fashion
T5719 1827-1839 JJ denotes mediolateral
T5720 1848-1850 TO denotes to
T5721 1851-1855 VB denotes meet
T5722 1856-1859 DT denotes the
T5723 1873-1878 NNS denotes walls
T5724 1860-1867 JJ denotes lateral
T5725 1868-1872 NN denotes body
T5726 1878-1880 , denotes ,
T5727 1880-1884 IN denotes with
T5728 1885-1886 DT denotes a
T5729 1894-1901 NN denotes paucity
T5730 1887-1893 JJ denotes normal
T5731 1902-1904 IN denotes of
T5732 1905-1911 NN denotes muscle
T5733 1912-1918 NNS denotes fibers
T5734 1919-1921 IN denotes in
T5735 1922-1925 DT denotes the
T5736 1944-1950 NN denotes region
T5737 1926-1933 JJ denotes central
T5738 1934-1943 JJ denotes tendonous
T5739 1950-1951 . denotes .
T5740 1951-2110 sentence denotes In the mutant diaphragm, myotubules radiated in a dorsal–ventral orientation, and muscle tissue did not meet the entire surface of the body walls (Figure 1B).
T5741 1952-1954 IN denotes In
T5742 1988-1996 VBN denotes radiated
T5743 1955-1958 DT denotes the
T5744 1966-1975 NN denotes diaphragm
T5745 1959-1965 NN denotes mutant
T5746 1975-1977 , denotes ,
T5747 1977-1987 NNS denotes myotubules
T5748 1997-1999 IN denotes in
T5749 2000-2001 DT denotes a
T5750 2017-2028 NN denotes orientation
T5751 2002-2008 JJ denotes dorsal
T5752 2009-2016 JJ denotes ventral
T5753 2008-2009 HYPH denotes –
T5754 2028-2030 , denotes ,
T5755 2030-2033 CC denotes and
T5756 2034-2040 NN denotes muscle
T5757 2041-2047 NN denotes tissue
T5758 2056-2060 VB denotes meet
T5759 2048-2051 VBD denotes did
T5760 2052-2055 RB denotes not
T5869 3058-3071 RB denotes progressively
T5870 3072-3078 JJR denotes higher
T5871 3084-3086 IN denotes of
T5872 3087-3093 NN denotes demise
T5873 3094-3101 IN denotes between
T5874 3102-3107 NN denotes E13.5
T5875 3108-3111 CC denotes and
T5876 3112-3117 NN denotes E15.5
T5877 3117-3118 . denotes .
T5878 3118-3215 sentence denotes At E12.5, 20 out of 87 (23%) were homozygous for the mutation, and all of these appeared viable.
T5879 3119-3121 IN denotes At
T5880 3148-3152 VBD denotes were
T5881 3122-3127 NN denotes E12.5
T5882 3127-3129 , denotes ,
T5883 3129-3131 CD denotes 20
T5884 3139-3141 CD denotes 87
T5885 3132-3135 IN denotes out
T5886 3136-3138 IN denotes of
T5887 3142-3143 -LRB- denotes (
T5888 3145-3146 NN denotes %
T5889 3143-3145 CD denotes 23
T5890 3146-3147 -RRB- denotes )
T5891 3153-3163 JJ denotes homozygous
T5892 3164-3167 IN denotes for
T5893 3168-3171 DT denotes the
T5894 3172-3180 NN denotes mutation
T5895 3180-3182 , denotes ,
T5896 3182-3185 CC denotes and
T5897 3186-3189 DT denotes all
T5898 3199-3207 VBD denotes appeared
T5899 3190-3192 IN denotes of
T5900 3193-3198 DT denotes these
T5901 3208-3214 JJ denotes viable
T5902 3214-3215 . denotes .
T5903 3215-3270 sentence denotes At E13.5, 13 of 49 (27%) were mutant and two had died.
T5904 3216-3218 IN denotes At
T5905 3241-3245 VBD denotes were
T5906 3219-3224 NN denotes E13.5
T5907 3224-3226 , denotes ,
T5908 3226-3228 CD denotes 13
T5909 3232-3234 CD denotes 49
T5910 3229-3231 IN denotes of
T5911 3235-3236 -LRB- denotes (
T5912 3238-3239 NN denotes %
T5913 3236-3238 CD denotes 27
T5914 3239-3240 -RRB- denotes )
T5915 3246-3252 JJ denotes mutant
T5916 3253-3256 CC denotes and
T5917 3257-3260 CD denotes two
T5918 3265-3269 VBN denotes died
T5919 3261-3264 VBD denotes had
T5920 3269-3270 . denotes .
T5921 3270-3375 sentence denotes At E15.5, 22 out of 91 (24%) were mutant and the majority of mutant embryos (17 out of the 22) had died.
T5922 3271-3273 IN denotes At
T5923 3300-3304 VBD denotes were
T5924 3274-3279 NN denotes E15.5
T5925 3279-3281 , denotes ,
T5926 3281-3283 CD denotes 22
T5927 3291-3293 CD denotes 91
T5928 3284-3287 IN denotes out
T5929 3288-3290 IN denotes of
T5930 3294-3295 -LRB- denotes (
T5931 3297-3298 NN denotes %
T5932 3295-3297 CD denotes 24
T5933 3298-3299 -RRB- denotes )
T5934 3305-3311 JJ denotes mutant
T5935 3312-3315 CC denotes and
T5936 3316-3319 DT denotes the
T5937 3320-3328 NN denotes majority
T5938 3370-3374 VBN denotes died
T5939 3329-3331 IN denotes of
T5940 3332-3338 NN denotes mutant
T5941 3339-3346 NNS denotes embryos
T5942 3347-3348 -LRB- denotes (
T5943 3362-3364 CD denotes 22
T5944 3348-3350 CD denotes 17
T5945 3351-3354 IN denotes out
T5946 3355-3357 IN denotes of
T5947 3358-3361 DT denotes the
T5948 3364-3365 -RRB- denotes )
T5949 3366-3369 VBD denotes had
T5950 3374-3375 . denotes .
T5951 3375-3481 sentence denotes By E18.5, nine of 29 embryos (31%) were homozygous for the mutation, of which only one embryo was viable.
T5952 3376-3378 IN denotes By
T5953 3411-3415 VBD denotes were
T5954 3379-3384 NN denotes E18.5
T5955 3384-3386 , denotes ,
T5956 3386-3390 CD denotes nine
T5957 3394-3396 CD denotes 29
T5958 3391-3393 IN denotes of
T5959 3397-3404 NNS denotes embryos
T5960 3405-3406 -LRB- denotes (
T5961 3408-3409 NN denotes %
T5962 3406-3408 CD denotes 31
T5963 3409-3410 -RRB- denotes )
T5964 3416-3426 JJ denotes homozygous
T5965 3427-3430 IN denotes for
T5966 3431-3434 DT denotes the
T5967 3435-3443 NN denotes mutation
T5968 3443-3445 , denotes ,
T5969 3445-3447 IN denotes of
T5970 3470-3473 VBD denotes was
T5971 3448-3453 WDT denotes which
T5972 3454-3458 RB denotes only
T5973 3463-3469 NN denotes embryo
T5974 3459-3462 CD denotes one
T5975 3474-3480 JJ denotes viable
T5976 3480-3481 . denotes .
T5977 3481-3562 sentence denotes Diaphragmatic muscularization was abnormal in all mutant mice examined (n > 25).
T5978 3482-3495 JJ denotes Diaphragmatic
T5979 3496-3511 NN denotes muscularization
T5980 3512-3515 VBD denotes was
T5981 3516-3524 JJ denotes abnormal
T5982 3525-3527 IN denotes in
T5983 3528-3531 DT denotes all
T5984 3539-3543 NNS denotes mice
T5985 3532-3538 NN denotes mutant
T5986 3544-3552 VBN denotes examined
T5987 3553-3554 -LRB- denotes (
T5988 3558-3560 CD denotes 25
T5989 3554-3555 NN denotes n
T5990 3556-3557 SYM denotes >
T5991 3560-3561 -RRB- denotes )
T5992 3561-3562 . denotes .
T5993 3562-3678 sentence denotes Pulmonary hypoplasia was observed in 100% of mutants evaluated for that phenotype between E11.5 and birth (n > 50).
T5994 3563-3572 JJ denotes Pulmonary
T5995 3573-3583 NN denotes hypoplasia
T5996 3588-3596 VBN denotes observed
T5997 3584-3587 VBD denotes was
T5998 3597-3599 IN denotes in
T5999 3600-3603 CD denotes 100
T6000 3603-3604 NN denotes %
T6001 3605-3607 IN denotes of
T6002 3608-3615 NNS denotes mutants
T6003 3616-3625 VBN denotes evaluated
T6004 3626-3629 IN denotes for
T6005 3630-3634 DT denotes that
T6006 3635-3644 NN denotes phenotype
T6007 3645-3652 IN denotes between
T6008 3653-3658 NN denotes E11.5
T6009 3659-3662 CC denotes and
T6010 3663-3668 NN denotes birth
T6011 3669-3670 -LRB- denotes (
T6012 3674-3676 CD denotes 50
T6013 3670-3671 NN denotes n
T6014 3672-3673 SYM denotes >
T6015 3676-3677 -RRB- denotes )
T6016 3677-3678 . denotes .
T6017 3678-3936 sentence denotes Examination of cardiac morphology showed that hearts from E15.5 lil mutant mice had a variety of developmental defects, including enlarged and abnormally developed endocardial cushions, a double-outlet right ventricle, and a complete atrioventricular canal.
T6018 3679-3690 NN denotes Examination
T6019 3713-3719 VBD denotes showed
T6020 3691-3693 IN denotes of
T6021 3694-3701 JJ denotes cardiac
T6022 3702-3712 NN denotes morphology
T6023 3720-3724 IN denotes that
T6024 3759-3762 VBD denotes had
T6025 3725-3731 NNS denotes hearts
T6026 3732-3736 IN denotes from
T6027 3737-3742 NN denotes E15.5
T6028 3754-3758 NNS denotes mice
T6029 3743-3746 NN denotes lil
T6030 3747-3753 NN denotes mutant
T6031 3763-3764 DT denotes a
T6032 3765-3772 NN denotes variety
T6033 3773-3775 IN denotes of
T6034 3776-3789 JJ denotes developmental
T6035 3790-3797 NNS denotes defects
T6036 3797-3799 , denotes ,
T6037 3799-3808 VBG denotes including
T6038 3809-3817 VBN denotes enlarged
T6039 3855-3863 NNS denotes cushions
T6040 3818-3821 CC denotes and
T6041 3822-3832 RB denotes abnormally
T6042 3833-3842 VBN denotes developed
T6043 3843-3854 JJ denotes endocardial
T6044 3863-3865 , denotes ,
T6045 3865-3866 DT denotes a
T6046 3887-3896 NN denotes ventricle
T6047 3867-3873 JJ denotes double
T6048 3874-3880 NN denotes outlet
T6049 3873-3874 HYPH denotes -
T6050 3881-3886 JJ denotes right
T6051 3896-3898 , denotes ,
T6052 3898-3901 CC denotes and
T6053 3902-3903 DT denotes a
T6054 3930-3935 NN denotes canal
T6055 3904-3912 JJ denotes complete
T6056 3913-3929 JJ denotes atrioventricular
T6057 3935-3936 . denotes .
T6058 3936-4046 sentence denotes The myocardium was also poorly developed, with thinning of the outer compact layer and decreased vascularity.
T6059 3937-3940 DT denotes The
T6060 3941-3951 NN denotes myocardium
T6061 3952-3955 VBD denotes was
T6062 3956-3960 RB denotes also
T6063 3961-3967 RB denotes poorly
T6064 3968-3977 VBN denotes developed
T6065 3977-3979 , denotes ,
T6066 3979-3983 IN denotes with
T6067 3984-3992 NN denotes thinning
T6068 3993-3995 IN denotes of
T6069 3996-3999 DT denotes the
T6070 4014-4019 NN denotes layer
T6071 4000-4005 JJ denotes outer
T6072 4006-4013 JJ denotes compact
T6073 4020-4023 CC denotes and
T6074 4024-4033 VBN denotes decreased
T6075 4034-4045 NN denotes vascularity
T6076 4045-4046 . denotes .
T6077 4046-4266 sentence denotes The cohort of mutant mice that survived to birth also had cardiac malformations including atrioventricular-canal-type ventricular septal defects, ostium primum atrial septal defects, and enlarged atria (data not shown).
T6078 4047-4050 DT denotes The
T6079 4051-4057 NN denotes cohort
T6080 4101-4104 VBD denotes had
T6081 4058-4060 IN denotes of
T6082 4061-4067 NN denotes mutant
T6083 4068-4072 NNS denotes mice
T6084 4073-4077 WDT denotes that
T6085 4078-4086 VBD denotes survived
T6086 4087-4089 IN denotes to
T6087 4090-4095 NN denotes birth
T6088 4096-4100 RB denotes also
T6089 4105-4112 JJ denotes cardiac
T6090 4113-4126 NNS denotes malformations
T6091 4127-4136 VBG denotes including
T6092 4137-4153 JJ denotes atrioventricular
T6093 4154-4159 NN denotes canal
T6094 4153-4154 HYPH denotes -
T6095 4160-4164 NN denotes type
T6096 4159-4160 HYPH denotes -
T6097 4184-4191 NNS denotes defects
T6098 4165-4176 JJ denotes ventricular
T6099 4177-4183 JJ denotes septal
T6100 4191-4193 , denotes ,
T6101 4193-4199 NN denotes ostium
T6102 4221-4228 NNS denotes defects
T6103 4200-4206 NN denotes primum
T6104 4207-4213 JJ denotes atrial
T6105 4214-4220 JJ denotes septal
T6106 4228-4230 , denotes ,
T6107 4230-4233 CC denotes and
T6108 4234-4242 VBN denotes enlarged
T6109 4243-4248 NNS denotes atria
T6110 4249-4250 -LRB- denotes (
T6111 4259-4264 VBN denotes shown
T6112 4250-4254 NNS denotes data
T6113 4255-4258 RB denotes not
T6114 4264-4265 -RRB- denotes )
T6115 4265-4266 . denotes .
T6116 4266-4368 sentence denotes All mutants specifically evaluated for a cardiac phenotype (n = 10) had abnormal cardiac development.
T6117 4267-4270 DT denotes All
T6118 4271-4278 NNS denotes mutants
T6119 4335-4338 VBD denotes had
T6120 4279-4291 RB denotes specifically
T6121 4292-4301 VBN denotes evaluated
T6122 4302-4305 IN denotes for
T6123 4306-4307 DT denotes a
T6124 4316-4325 NN denotes phenotype
T6125 4308-4315 JJ denotes cardiac
T6126 4326-4327 -LRB- denotes (
T6127 4331-4333 CD denotes 10
T6128 4327-4328 NN denotes n
T6129 4329-4330 SYM denotes =
T6130 4333-4334 -RRB- denotes )
T6131 4339-4347 JJ denotes abnormal
T6132 4356-4367 NN denotes development
T6133 4348-4355 JJ denotes cardiac
T6134 4367-4368 . denotes .
T6135 4368-4523 sentence denotes Examination of the 3-Mb region between D15Mit85 and D15Mit5 in DNA sequence databases revealed three predicted genes and four known genes, including Fog2.
T6136 4369-4380 NN denotes Examination
T6137 4455-4463 VBD denotes revealed
T6138 4381-4383 IN denotes of
T6139 4384-4387 DT denotes the
T6140 4393-4399 NN denotes region
T6141 4388-4389 CD denotes 3
T6142 4390-4392 NN denotes Mb
T6143 4389-4390 HYPH denotes -
T6144 4400-4407 IN denotes between
T6145 4408-4416 NN denotes D15Mit85
T6146 4417-4420 CC denotes and
T6147 4421-4428 NN denotes D15Mit5
T6148 4429-4431 IN denotes in
T6149 4432-4435 NN denotes DNA
T6150 4436-4444 NN denotes sequence
T6151 4445-4454 NNS denotes databases
T6152 4464-4469 CD denotes three
T6153 4480-4485 NNS denotes genes
T6154 4470-4479 VBN denotes predicted
T6155 4486-4489 CC denotes and
T6156 4490-4494 CD denotes four
T6157 4501-4506 NNS denotes genes
T6158 4495-4500 JJ denotes known
T6159 4506-4508 , denotes ,
T6160 4508-4517 VBG denotes including
T6161 4518-4522 NN denotes Fog2
T6162 4522-4523 . denotes .
T6163 4523-4733 sentence denotes Targeted mutations of Fog2 have cardiac defects strikingly similar to those we identified in lil mutant mice, including atrioventricular canal defects, thinned myocardium, and absent coronary vasculature [16].
T6164 4524-4532 VBN denotes Targeted
T6165 4533-4542 NNS denotes mutations
T6166 4551-4555 VBP denotes have
T6167 4543-4545 IN denotes of
T6168 4546-4550 NN denotes Fog2
T6169 4556-4563 JJ denotes cardiac
T6170 4564-4571 NNS denotes defects
T6171 4572-4582 RB denotes strikingly
T6172 4583-4590 JJ denotes similar
T6173 4591-4593 IN denotes to
T6174 4594-4599 DT denotes those
T6175 4600-4602 PRP denotes we
T6176 4603-4613 VBD denotes identified
T6177 4614-4616 IN denotes in
T6178 4617-4620 NN denotes lil
T6179 4628-4632 NNS denotes mice
T6180 4621-4627 NN denotes mutant
T6181 4632-4634 , denotes ,
T6182 4634-4643 VBG denotes including
T6183 4644-4660 JJ denotes atrioventricular
T6184 4667-4674 NNS denotes defects
T6185 4661-4666 NN denotes canal
T6186 4674-4676 , denotes ,
T6187 4676-4683 VBN denotes thinned
T6188 4684-4694 NN denotes myocardium
T6189 4694-4696 , denotes ,
T6190 4696-4699 CC denotes and
T6191 4700-4706 JJ denotes absent
T6192 4716-4727 NN denotes vasculature
T6193 4707-4715 JJ denotes coronary
T6194 4728-4729 -LRB- denotes [
T6195 4729-4731 CD denotes 16
T6196 4731-4732 -RRB- denotes ]
T6197 4732-4733 . denotes .
T6198 4733-4875 sentence denotes RT-PCR amplification of the proximal portion of Fog2 revealed longer transcripts in the lil mutant than in the wild-type embryos (Figure 2A).
T6199 4734-4736 NN denotes RT
T6200 4737-4740 NN denotes PCR
T6201 4736-4737 HYPH denotes -
T6202 4741-4754 NN denotes amplification
T6203 4787-4795 VBD denotes revealed
T6204 4755-4757 IN denotes of
T6205 4758-4761 DT denotes the
T6206 4771-4778 NN denotes portion
T6207 4762-4770 JJ denotes proximal
T6208 4779-4781 IN denotes of
T6209 4782-4786 NN denotes Fog2
T6210 4796-4802 JJR denotes longer
T6211 4803-4814 NNS denotes transcripts
T6212 4815-4817 IN denotes in
T6213 4818-4821 DT denotes the
T6214 4826-4832 NN denotes mutant
T6215 4822-4825 NN denotes lil
T6216 4833-4837 IN denotes than
T6217 4838-4840 IN denotes in
T6218 4841-4844 DT denotes the
T6219 4850-4854 NN denotes type
T6220 4845-4849 JJ denotes wild
T6221 4849-4850 HYPH denotes -
T6222 4855-4862 NNS denotes embryos
T6223 4863-4864 -LRB- denotes (
T6224 4864-4870 NN denotes Figure
T6225 4871-4873 CD denotes 2A
T6226 4873-4874 -RRB- denotes )
T6227 4874-4875 . denotes .
T6228 4875-5053 sentence denotes Sequencing of the mutant transcript revealed a point mutation (from thymine to cytosine) 2 bp after position 301, which is in the splice donor site at the end of the third exon.
T6229 4876-4886 NN denotes Sequencing
T6230 4912-4920 VBD denotes revealed
T6231 4887-4889 IN denotes of
T6232 4890-4893 DT denotes the
T6233 4901-4911 NN denotes transcript
T6234 4894-4900 NN denotes mutant
T6235 4921-4922 DT denotes a
T6236 4929-4937 NN denotes mutation
T6237 4923-4928 NN denotes point
T6238 4938-4939 -LRB- denotes (
T6239 4939-4943 IN denotes from
T6240 4944-4951 NN denotes thymine
T6241 4952-4954 IN denotes to
T6242 4955-4963 NN denotes cytosine
T6243 4963-4964 -RRB- denotes )
T6244 4965-4966 CD denotes 2
T6245 4967-4969 NN denotes bp
T6246 4970-4975 IN denotes after
T6247 4976-4984 NN denotes position
T6248 4985-4988 CD denotes 301
T6249 4988-4990 , denotes ,
T6250 4990-4995 WDT denotes which
T6251 4996-4998 VBZ denotes is
T6252 4999-5001 IN denotes in
T6253 5002-5005 DT denotes the
T6254 5019-5023 NN denotes site
T6255 5006-5012 NN denotes splice
T6256 5013-5018 NN denotes donor
T6257 5024-5026 IN denotes at
T6258 5027-5030 DT denotes the
T6259 5031-5034 NN denotes end
T6260 5035-5037 IN denotes of
T6261 5038-5041 DT denotes the
T6262 5048-5052 NN denotes exon
T6263 5042-5047 JJ denotes third
T6264 5052-5053 . denotes .
T6265 5053-5273 sentence denotes This mutation causes a splicing defect that results in the insertion of 85 bp of intronic sequence into the mutant transcript, and introduces a stop codon that generates a severely truncated protein product (Figure 2B).
T6266 5054-5058 DT denotes This
T6267 5059-5067 NN denotes mutation
T6268 5068-5074 VBZ denotes causes
T6269 5075-5076 DT denotes a
T6270 5086-5092 NN denotes defect
T6271 5077-5085 NN denotes splicing
T6272 5093-5097 WDT denotes that
T6273 5098-5105 VBZ denotes results
T6274 5106-5108 IN denotes in
T6275 5109-5112 DT denotes the
T6276 5113-5122 NN denotes insertion
T6277 5123-5125 IN denotes of
T6278 5126-5128 CD denotes 85
T6279 5129-5131 NN denotes bp
T6280 5132-5134 IN denotes of
T6281 5135-5143 JJ denotes intronic
T6282 5144-5152 NN denotes sequence
T6283 5153-5157 IN denotes into
T6284 5158-5161 DT denotes the
T6285 5169-5179 NN denotes transcript
T6286 5162-5168 NN denotes mutant
T6287 5179-5181 , denotes ,
T6288 5181-5184 CC denotes and
T6289 5185-5195 VBZ denotes introduces
T6290 5196-5197 DT denotes a
T6291 5203-5208 NN denotes codon
T6292 5198-5202 NN denotes stop
T6293 5209-5213 WDT denotes that
T6294 5214-5223 VBZ denotes generates
T6295 5224-5225 DT denotes a
T6296 5253-5260 NN denotes product
T6297 5226-5234 RB denotes severely
T6298 5235-5244 VBN denotes truncated
T6299 5245-5252 NN denotes protein
T6300 5261-5262 -LRB- denotes (
T6301 5262-5268 NN denotes Figure
T6302 5269-5271 CD denotes 2B
T6303 5271-5272 -RRB- denotes )
T6304 5272-5273 . denotes .
T6305 5273-5386 sentence denotes Heterozygous lil mutant mice were crossed with a Fog2 +/− (null allele) mutant generated by gene targeting [16].
T6306 5274-5286 JJ denotes Heterozygous
T6307 5298-5302 NNS denotes mice
T6308 5287-5290 NN denotes lil
T6309 5291-5297 NN denotes mutant
T6310 5308-5315 VBN denotes crossed
T6311 5303-5307 VBD denotes were
T6312 5316-5320 IN denotes with
T6313 5321-5322 DT denotes a
T6314 5346-5352 NN denotes mutant
T6315 5323-5327 NN denotes Fog2
T6316 5328-5329 SYM denotes +
T6317 5329-5330 HYPH denotes /
T6318 5330-5331 SYM denotes −
T6319 5332-5333 -LRB- denotes (
T6320 5338-5344 NN denotes allele
T6321 5333-5337 JJ denotes null
T6322 5344-5345 -RRB- denotes )
T6323 5353-5362 VBN denotes generated
T6324 5363-5365 IN denotes by
T6325 5366-5370 NN denotes gene
T6326 5371-5380 NN denotes targeting
T6327 5381-5382 -LRB- denotes [
T6328 5382-5384 CD denotes 16
T6329 5384-5385 -RRB- denotes ]
T6330 5385-5386 . denotes .
T6331 5386-5512 sentence denotes Doubly heterozygous mice had an embryonic lethal phenotype; this failure to complement proves that lil is a mutation in Fog2.
T6332 5387-5393 RB denotes Doubly
T6333 5394-5406 JJ denotes heterozygous
T6334 5407-5411 NNS denotes mice
T6335 5412-5415 VBD denotes had
T6336 5474-5480 VBZ denotes proves
T6337 5416-5418 DT denotes an
T6338 5436-5445 NN denotes phenotype
T6339 5419-5428 JJ denotes embryonic
T6340 5429-5435 JJ denotes lethal
T6341 5445-5446 : denotes ;
T6342 5447-5451 DT denotes this
T6343 5452-5459 NN denotes failure
T6344 5460-5462 TO denotes to
T6345 5463-5473 VB denotes complement
T6346 5481-5485 IN denotes that
T6347 5490-5492 VBZ denotes is
T6348 5486-5489 NN denotes lil
T6349 5493-5494 DT denotes a
T6350 5495-5503 NN denotes mutation
T6351 5504-5506 IN denotes in
T6352 5507-5511 NN denotes Fog2
T6353 5511-5512 . denotes .
T6354 5512-5715 sentence denotes The variable phenotype of lil mice (relative to that found for the Fog2 null mutant) is likely due to the generation of a low level of normal transcript despite the presence of the splice site mutation.
T6355 5513-5516 DT denotes The
T6356 5526-5535 NN denotes phenotype
T6357 5517-5525 JJ denotes variable
T6358 5598-5600 VBZ denotes is
T6359 5536-5538 IN denotes of
T6360 5539-5542 NN denotes lil
T6361 5543-5547 NNS denotes mice
T6362 5548-5549 -LRB- denotes (
T6363 5549-5557 JJ denotes relative
T6364 5558-5560 IN denotes to
T6365 5561-5565 DT denotes that
T6366 5566-5571 VBN denotes found
T6367 5572-5575 IN denotes for
T6368 5576-5579 DT denotes the
T6369 5590-5596 NN denotes mutant
T6370 5580-5584 NN denotes Fog2
T6371 5585-5589 JJ denotes null
T6372 5596-5597 -RRB- denotes )
T6373 5601-5607 RB denotes likely
T6374 5608-5611 IN denotes due
T6375 5612-5614 IN denotes to
T6376 5615-5618 DT denotes the
T6377 5619-5629 NN denotes generation
T6378 5630-5632 IN denotes of
T6379 5633-5634 DT denotes a
T6380 5639-5644 NN denotes level
T6381 5635-5638 JJ denotes low
T6382 5645-5647 IN denotes of
T6383 5648-5654 JJ denotes normal
T6384 5655-5665 NN denotes transcript
T6385 5666-5673 IN denotes despite
T6386 5674-5677 DT denotes the
T6387 5678-5686 NN denotes presence
T6388 5687-5689 IN denotes of
T6389 5690-5693 DT denotes the
T6390 5706-5714 NN denotes mutation
T6391 5694-5700 NN denotes splice
T6392 5701-5705 NN denotes site
T6393 5714-5715 . denotes .
T8822 10783-10787 DT denotes this
T8121 6141-6145 NN denotes Lung
T8122 6160-6171 NN denotes Development
T8123 6146-6149 CC denotes and
T8124 6150-6159 NN denotes Diaphragm
T8125 6172-6174 IN denotes in
T8126 6175-6178 DT denotes the
T8127 6191-6196 NN denotes Mouse
T8128 6179-6183 NN denotes Fog2
T8129 6184-6190 NN denotes Mutant
T8130 6196-6296 sentence denotes Experiments were conducted to evaluate the role of Fog2 in pulmonary and diaphragmatic development.
T8131 6197-6208 NNS denotes Experiments
T8132 6214-6223 VBN denotes conducted
T8133 6209-6213 VBD denotes were
T8134 6224-6226 TO denotes to
T8135 6227-6235 VB denotes evaluate
T8136 6236-6239 DT denotes the
T8137 6240-6244 NN denotes role
T8138 6245-6247 IN denotes of
T8139 6248-6252 NN denotes Fog2
T8140 6253-6255 IN denotes in
T8141 6256-6265 JJ denotes pulmonary
T8142 6284-6295 NN denotes development
T8143 6266-6269 CC denotes and
T8144 6270-6283 JJ denotes diaphragmatic
T8145 6295-6296 . denotes .
T8146 6296-6439 sentence denotes The pulmonary phenotype is characterized by diffuse hypoplasia and specific loss of the accessory lobe and a portion of the right middle lobe.
T8147 6297-6300 DT denotes The
T8148 6311-6320 NN denotes phenotype
T8149 6301-6310 JJ denotes pulmonary
T8150 6324-6337 VBN denotes characterized
T8151 6321-6323 VBZ denotes is
T8152 6338-6340 IN denotes by
T8153 6341-6348 JJ denotes diffuse
T8154 6349-6359 NN denotes hypoplasia
T8155 6360-6363 CC denotes and
T8156 6364-6372 JJ denotes specific
T8157 6373-6377 NN denotes loss
T8158 6378-6380 IN denotes of
T8159 6381-6384 DT denotes the
T8160 6395-6399 NN denotes lobe
T8161 6385-6394 JJ denotes accessory
T8162 6400-6403 CC denotes and
T8163 6404-6405 DT denotes a
T8164 6406-6413 NN denotes portion
T8165 6414-6416 IN denotes of
T8166 6417-6420 DT denotes the
T8167 6434-6438 NN denotes lobe
T8168 6421-6426 JJ denotes right
T8169 6427-6433 JJ denotes middle
T8170 6438-6439 . denotes .
T8171 6439-6669 sentence denotes It is well established that abnormalities in either diaphragmatic development or fetal breathing can result in a secondary pulmonary hypoplasia, although loss of normal structure has never been documented in this context [17,18].
T8172 6440-6442 PRP denotes It
T8173 6443-6445 VBZ denotes is
T8174 6446-6450 RB denotes well
T8175 6451-6462 VBN denotes established
T8176 6463-6467 IN denotes that
T8177 6541-6547 VB denotes result
T8178 6468-6481 NNS denotes abnormalities
T8179 6482-6484 IN denotes in
T8180 6485-6491 CC denotes either
T8181 6506-6517 NN denotes development
T8182 6492-6505 JJ denotes diaphragmatic
T8183 6518-6520 CC denotes or
T8184 6521-6526 JJ denotes fetal
T8185 6527-6536 NN denotes breathing
T8186 6537-6540 MD denotes can
T8187 6548-6550 IN denotes in
T8188 6551-6552 DT denotes a
T8189 6573-6583 NN denotes hypoplasia
T8190 6553-6562 JJ denotes secondary
T8191 6563-6572 JJ denotes pulmonary
T8192 6583-6585 , denotes ,
T8193 6585-6593 IN denotes although
T8194 6634-6644 VBN denotes documented
T8195 6594-6598 NN denotes loss
T8196 6599-6601 IN denotes of
T8197 6602-6608 JJ denotes normal
T8198 6609-6618 NN denotes structure
T8199 6619-6622 VBZ denotes has
T8200 6623-6628 RB denotes never
T8201 6629-6633 VBN denotes been
T8202 6645-6647 IN denotes in
T8203 6648-6652 DT denotes this
T8204 6653-6660 NN denotes context
T8205 6661-6662 -LRB- denotes [
T8206 6665-6667 CD denotes 18
T8207 6662-6664 CD denotes 17
T8208 6664-6665 , denotes ,
T8209 6667-6668 -RRB- denotes ]
T8210 6668-6669 . denotes .
T8211 6669-6875 sentence denotes Fog2 is expressed diffusely in the pulmonary mesenchyme during the period of branching morphogenesis, while later expression is restricted to the smooth muscles of airways and pulmonary vessels (Figure 3).
T8212 6670-6674 NN denotes Fog2
T8213 6678-6687 VBN denotes expressed
T8214 6675-6677 VBZ denotes is
T8215 6688-6697 RB denotes diffusely
T8216 6698-6700 IN denotes in
T8217 6701-6704 DT denotes the
T8218 6715-6725 NN denotes mesenchyme
T8219 6705-6714 JJ denotes pulmonary
T8220 6726-6732 IN denotes during
T8221 6733-6736 DT denotes the
T8222 6737-6743 NN denotes period
T8223 6744-6746 IN denotes of
T8224 6747-6756 NN denotes branching
T8225 6757-6770 NN denotes morphogenesis
T8226 6770-6772 , denotes ,
T8227 6772-6777 IN denotes while
T8228 6798-6808 VBN denotes restricted
T8229 6778-6783 JJ denotes later
T8230 6784-6794 NN denotes expression
T8231 6795-6797 VBZ denotes is
T8232 6809-6811 IN denotes to
T8233 6812-6815 DT denotes the
T8234 6823-6830 NNS denotes muscles
T8235 6816-6822 JJ denotes smooth
T8236 6831-6833 IN denotes of
T8237 6834-6841 NNS denotes airways
T8238 6842-6845 CC denotes and
T8239 6846-6855 JJ denotes pulmonary
T8240 6856-6863 NNS denotes vessels
T8241 6864-6865 -LRB- denotes (
T8242 6865-6871 NN denotes Figure
T8243 6872-6873 CD denotes 3
T8244 6873-6874 -RRB- denotes )
T8245 6874-6875 . denotes .
T8246 6875-7101 sentence denotes This, and the observation that lungs appeared small on transverse sections evaluated prior to diaphragmatic muscularization or function, suggests that the pulmonary hypoplasia occurs independently of the diaphragmatic defect.
T8247 6876-6880 DT denotes This
T8248 7013-7021 VBZ denotes suggests
T8249 6880-6882 , denotes ,
T8250 6882-6885 CC denotes and
T8251 6886-6889 DT denotes the
T8252 6890-6901 NN denotes observation
T8253 6902-6906 IN denotes that
T8254 6913-6921 VBD denotes appeared
T8255 6907-6912 NNS denotes lungs
T8256 6922-6927 JJ denotes small
T8257 6928-6930 IN denotes on
T8258 6931-6941 JJ denotes transverse
T8259 6942-6950 NNS denotes sections
T8260 6951-6960 VBN denotes evaluated
T8261 6961-6966 JJ denotes prior
T8262 6967-6969 IN denotes to
T8263 6970-6983 JJ denotes diaphragmatic
T8264 6984-6999 NN denotes muscularization
T8265 7000-7002 CC denotes or
T8266 7003-7011 NN denotes function
T8267 7011-7013 , denotes ,
T8268 7022-7026 IN denotes that
T8269 7052-7058 VBZ denotes occurs
T8270 7027-7030 DT denotes the
T8271 7041-7051 NN denotes hypoplasia
T8272 7031-7040 JJ denotes pulmonary
T8273 7059-7072 RB denotes independently
T8274 7073-7075 IN denotes of
T8275 7076-7079 DT denotes the
T8276 7094-7100 NN denotes defect
T8277 7080-7093 JJ denotes diaphragmatic
T8278 7100-7101 . denotes .
T8279 7101-7238 sentence denotes To test this hypothesis, lungs were dissected from Fog2 −/− mice and littermate controls before the onset of fetal diaphragmatic motion.
T8280 7102-7104 TO denotes To
T8281 7105-7109 VB denotes test
T8282 7138-7147 VBN denotes dissected
T8283 7110-7114 DT denotes this
T8284 7115-7125 NN denotes hypothesis
T8285 7125-7127 , denotes ,
T8286 7127-7132 NNS denotes lungs
T8287 7133-7137 VBD denotes were
T8288 7148-7152 IN denotes from
T8289 7153-7157 NN denotes Fog2
T8290 7162-7166 NNS denotes mice
T8291 7158-7159 SYM denotes −
T8292 7159-7160 HYPH denotes /
T8293 7160-7161 SYM denotes −
T8294 7167-7170 CC denotes and
T8295 7171-7181 NN denotes littermate
T8296 7182-7190 NNS denotes controls
T8297 7191-7197 IN denotes before
T8298 7198-7201 DT denotes the
T8299 7202-7207 NN denotes onset
T8300 7208-7210 IN denotes of
T8301 7211-7216 JJ denotes fetal
T8302 7231-7237 NN denotes motion
T8303 7217-7230 JJ denotes diaphragmatic
T8304 7237-7238 . denotes .
T8305 7238-7370 sentence denotes Fog2 −/− mice were used for this experiment, as we wanted to avoid potential phenotypic variance from the lil hypomorphic mutation.
T8306 7239-7243 NN denotes Fog2
T8307 7248-7252 NNS denotes mice
T8308 7244-7245 SYM denotes −
T8309 7245-7246 HYPH denotes /
T8310 7246-7247 SYM denotes −
T8311 7258-7262 VBN denotes used
T8312 7253-7257 VBD denotes were
T8313 7263-7266 IN denotes for
T8314 7267-7271 DT denotes this
T8315 7272-7282 NN denotes experiment
T8316 7282-7284 , denotes ,
T8317 7284-7286 IN denotes as
T8318 7290-7296 VBD denotes wanted
T8319 7287-7289 PRP denotes we
T8320 7297-7299 TO denotes to
T8321 7300-7305 VB denotes avoid
T8322 7306-7315 JJ denotes potential
T8323 7327-7335 NN denotes variance
T8324 7316-7326 JJ denotes phenotypic
T8325 7336-7340 IN denotes from
T8326 7341-7344 DT denotes the
T8327 7361-7369 NN denotes mutation
T8328 7345-7348 NN denotes lil
T8329 7349-7360 JJ denotes hypomorphic
T8330 7369-7370 . denotes .
T8331 7370-7485 sentence denotes Lungs dissected at E12 from Fog2 −/− embryos were smaller in size and lacked the development of an accessory lobe.
T8332 7371-7376 NNS denotes Lungs
T8333 7416-7420 VBD denotes were
T8334 7377-7386 VBN denotes dissected
T8335 7387-7389 IN denotes at
T8336 7390-7393 NN denotes E12
T8337 7394-7398 IN denotes from
T8338 7399-7403 NN denotes Fog2
T8339 7408-7415 NNS denotes embryos
T8340 7404-7405 SYM denotes −
T8341 7405-7406 HYPH denotes /
T8342 7406-7407 SYM denotes −
T8343 7421-7428 JJR denotes smaller
T8344 7429-7431 IN denotes in
T8345 7432-7436 NN denotes size
T8346 7437-7440 CC denotes and
T8347 7441-7447 VBD denotes lacked
T8348 7448-7451 DT denotes the
T8349 7452-7463 NN denotes development
T8350 7464-7466 IN denotes of
T8351 7467-7469 DT denotes an
T8352 7480-7484 NN denotes lobe
T8353 7470-7479 JJ denotes accessory
T8354 7484-7485 . denotes .
T8355 7485-7700 sentence denotes In 11 viable Fog2− /− lung culture explants, there was never development of an accessory lobe, and the weights of mutant lungs cultured for 5 d were significantly lower than those of littermate controls (Figure 4).
T8356 7486-7488 IN denotes In
T8357 7537-7540 VBD denotes was
T8358 7489-7491 CD denotes 11
T8359 7521-7529 NNS denotes explants
T8360 7492-7498 JJ denotes viable
T8361 7499-7503 NN denotes Fog2
T8362 7503-7504 SYM denotes −
T8363 7505-7506 HYPH denotes /
T8364 7506-7507 SYM denotes −
T8365 7508-7512 NN denotes lung
T8366 7513-7520 NN denotes culture
T8367 7529-7531 , denotes ,
T8368 7531-7536 EX denotes there
T8369 7541-7546 RB denotes never
T8370 7547-7558 NN denotes development
T8371 7559-7561 IN denotes of
T8372 7562-7564 DT denotes an
T8373 7575-7579 NN denotes lobe
T8374 7565-7574 JJ denotes accessory
T8375 7579-7581 , denotes ,
T8376 7581-7584 CC denotes and
T8377 7585-7588 DT denotes the
T8378 7589-7596 NNS denotes weights
T8379 7630-7634 VBD denotes were
T8380 7597-7599 IN denotes of
T8381 7600-7606 NN denotes mutant
T8382 7607-7612 NNS denotes lungs
T8383 7613-7621 VBN denotes cultured
T8384 7622-7625 IN denotes for
T8385 7626-7627 CD denotes 5
T8386 7628-7629 NN denotes d
T8387 7635-7648 RB denotes significantly
T8388 7649-7654 JJR denotes lower
T8389 7655-7659 IN denotes than
T8390 7660-7665 DT denotes those
T8391 7666-7668 IN denotes of
T8392 7669-7679 NN denotes littermate
T8393 7680-7688 NNS denotes controls
T8394 7689-7690 -LRB- denotes (
T8395 7690-7696 NN denotes Figure
T8396 7697-7698 CD denotes 4
T8397 7698-7699 -RRB- denotes )
T8398 7699-7700 . denotes .
T8399 7700-7794 sentence denotes These data demonstrate that the pulmonary hypoplasia in Fog2 mutant mice is a primary defect.
T8400 7701-7706 DT denotes These
T8401 7707-7711 NNS denotes data
T8402 7712-7723 VBP denotes demonstrate
T8403 7724-7728 IN denotes that
T8404 7774-7776 VBZ denotes is
T8405 7729-7732 DT denotes the
T8406 7743-7753 NN denotes hypoplasia
T8407 7733-7742 JJ denotes pulmonary
T8408 7754-7756 IN denotes in
T8409 7757-7761 NN denotes Fog2
T8410 7769-7773 NNS denotes mice
T8411 7762-7768 NN denotes mutant
T8412 7777-7778 DT denotes a
T8413 7787-7793 NN denotes defect
T8414 7779-7786 JJ denotes primary
T8415 7793-7794 . denotes .
T8416 7794-8578 sentence denotes Figure 3 Fog2 Is Expressed in the Developing Lung and Diaphragm Fog2 is expressed in the diffuse pulmonary mesenchyme at E13.5 (A) (arrow shows mesenchyme) and is restricted to the bronchial and vascular smooth muscle (sm) at E16.5 (B). Fog2 is expressed diffusely in the developing diaphragm (Dia) both prior to (E11.5) (C) and after muscularization (E13.5) (D). Figure 4 Fog2 Is Necessary for Primary Lung Development Fog2 null lungs removed prior to diaphragmatic muscularization and grown in vitro show no accessory lobe development. Accessory lobe is labeled with black arrow in control littermate lungs. Branching in the unaffected lobes appeared to be delayed by 6–12 h, but all mutants developed an intricate branching pattern in the unaffected lobes after culture for 5 d.
T8417 8407-8416 NN denotes Branching
T8418 8441-8449 VBD denotes appeared
T8419 8417-8419 IN denotes in
T8420 8420-8423 DT denotes the
T8421 8435-8440 NNS denotes lobes
T8422 8424-8434 JJ denotes unaffected
T8423 8450-8452 TO denotes to
T8424 8456-8463 VBN denotes delayed
T8425 8453-8455 VB denotes be
T8426 8464-8466 IN denotes by
T8427 8467-8468 CD denotes 6
T8428 8469-8471 CD denotes 12
T8429 8468-8469 SYM denotes –
T8430 8472-8473 NN denotes h
T8431 8473-8475 , denotes ,
T8432 8475-8478 CC denotes but
T8433 8479-8482 DT denotes all
T8434 8483-8490 NNS denotes mutants
T8435 8491-8500 VBD denotes developed
T8436 8501-8503 DT denotes an
T8437 8524-8531 NN denotes pattern
T8438 8504-8513 JJ denotes intricate
T8439 8514-8523 NN denotes branching
T8440 8532-8534 IN denotes in
T8441 8535-8538 DT denotes the
T8442 8550-8555 NNS denotes lobes
T8443 8539-8549 JJ denotes unaffected
T8444 8556-8561 IN denotes after
T8445 8562-8569 NN denotes culture
T8446 8570-8573 IN denotes for
T8447 8574-8575 CD denotes 5
T8448 8576-8577 NN denotes d
T8449 8577-8578 . denotes .
T8450 8578-8844 sentence denotes Because the Fog2 phenotype is striking for specific lobar loss, the spatial pattern of Fog2 expression was evaluated in normal embryos during the period of early lobar establishment to determine whether Fog2 expression is specifically different at these lobar buds.
T8451 8579-8586 IN denotes Because
T8452 8606-8608 VBZ denotes is
T8453 8587-8590 DT denotes the
T8454 8596-8605 NN denotes phenotype
T8455 8591-8595 NN denotes Fog2
T8456 8686-8695 VBN denotes evaluated
T8457 8609-8617 JJ denotes striking
T8458 8618-8621 IN denotes for
T8459 8622-8630 JJ denotes specific
T8460 8637-8641 NN denotes loss
T8461 8631-8636 NN denotes lobar
T8462 8641-8643 , denotes ,
T8463 8643-8646 DT denotes the
T8464 8655-8662 NN denotes pattern
T8465 8647-8654 JJ denotes spatial
T8466 8663-8665 IN denotes of
T8467 8666-8670 NN denotes Fog2
T8468 8671-8681 NN denotes expression
T8469 8682-8685 VBD denotes was
T8470 8696-8698 IN denotes in
T8471 8699-8705 JJ denotes normal
T8472 8706-8713 NNS denotes embryos
T8473 8714-8720 IN denotes during
T8474 8721-8724 DT denotes the
T8475 8725-8731 NN denotes period
T8476 8732-8734 IN denotes of
T8477 8735-8740 JJ denotes early
T8478 8747-8760 NN denotes establishment
T8479 8741-8746 NN denotes lobar
T8480 8761-8763 TO denotes to
T8481 8764-8773 VB denotes determine
T8482 8774-8781 IN denotes whether
T8483 8798-8800 VBZ denotes is
T8484 8782-8786 NN denotes Fog2
T8485 8787-8797 NN denotes expression
T8486 8801-8813 RB denotes specifically
T8487 8814-8823 JJ denotes different
T8488 8824-8826 IN denotes at
T8489 8827-8832 DT denotes these
T8490 8839-8843 NNS denotes buds
T8491 8833-8838 NN denotes lobar
T8492 8843-8844 . denotes .
T8493 8844-8964 sentence denotes Expression was evaluated in mice carrying a lacZ gene incorporated into the Fog2 locus (S. Tevosian, unpublished data).
T8494 8845-8855 NN denotes Expression
T8495 8860-8869 VBN denotes evaluated
T8496 8856-8859 VBD denotes was
T8497 8870-8872 IN denotes in
T8498 8873-8877 NNS denotes mice
T8499 8878-8886 VBG denotes carrying
T8500 8887-8888 DT denotes a
T8501 8894-8898 NN denotes gene
T8502 8889-8893 NN denotes lacZ
T8503 8899-8911 VBN denotes incorporated
T8504 8912-8916 IN denotes into
T8505 8917-8920 DT denotes the
T8506 8926-8931 NN denotes locus
T8507 8921-8925 NN denotes Fog2
T8508 8932-8933 -LRB- denotes (
T8509 8933-8935 NNP denotes S.
T8510 8936-8944 NNP denotes Tevosian
T8511 8944-8946 , denotes ,
T8512 8946-8957 JJ denotes unpublished
T8513 8958-8962 NNS denotes data
T8514 8962-8963 -RRB- denotes )
T8515 8963-8964 . denotes .
T8516 8964-9215 sentence denotes In nine mice examined at E11.5, all lungs showed a specific enhancement of Fog2 expression in the mesenchyme surrounding the accessory bud and the right middle lobe bud, which are the lobes that do not develop normally in Fog2 mutant mice (Figure 5).
T8517 8965-8967 IN denotes In
T8518 9007-9013 VBD denotes showed
T8519 8968-8972 CD denotes nine
T8520 8973-8977 NNS denotes mice
T8521 8978-8986 VBN denotes examined
T8522 8987-8989 IN denotes at
T8523 8990-8995 NN denotes E11.5
T8524 8995-8997 , denotes ,
T8525 8997-9000 DT denotes all
T8526 9001-9006 NNS denotes lungs
T8527 9014-9015 DT denotes a
T8528 9025-9036 NN denotes enhancement
T8529 9016-9024 JJ denotes specific
T8530 9037-9039 IN denotes of
T8531 9040-9044 NN denotes Fog2
T8532 9045-9055 NN denotes expression
T8533 9056-9058 IN denotes in
T8534 9059-9062 DT denotes the
T8535 9063-9073 NN denotes mesenchyme
T8536 9074-9085 VBG denotes surrounding
T8537 9086-9089 DT denotes the
T8538 9100-9103 NN denotes bud
T8539 9090-9099 JJ denotes accessory
T8540 9104-9107 CC denotes and
T8541 9108-9111 DT denotes the
T8542 9130-9133 NN denotes bud
T8543 9112-9117 JJ denotes right
T8544 9118-9124 JJ denotes middle
T8545 9125-9129 NN denotes lobe
T8546 9133-9135 , denotes ,
T8547 9135-9140 WDT denotes which
T8548 9141-9144 VBP denotes are
T8549 9145-9148 DT denotes the
T8550 9149-9154 NNS denotes lobes
T8551 9155-9159 WDT denotes that
T8552 9167-9174 VB denotes develop
T8553 9160-9162 VBP denotes do
T8554 9163-9166 RB denotes not
T8555 9175-9183 RB denotes normally
T8556 9184-9186 IN denotes in
T8557 9187-9191 NN denotes Fog2
T8558 9199-9203 NNS denotes mice
T8559 9192-9198 NN denotes mutant
T8560 9204-9205 -LRB- denotes (
T8561 9205-9211 NN denotes Figure
T8562 9212-9213 CD denotes 5
T8563 9213-9214 -RRB- denotes )
T8564 9214-9215 . denotes .
T8565 9215-9347 sentence denotes By E12.5, expression was diffuse in the pulmonary mesenchyme, as was seen previously with in situ hybridization on tissue sections.
T8566 9216-9218 IN denotes By
T8567 9237-9240 VBD denotes was
T8568 9219-9224 NN denotes E12.5
T8569 9224-9226 , denotes ,
T8570 9226-9236 NN denotes expression
T8571 9241-9248 JJ denotes diffuse
T8572 9249-9251 IN denotes in
T8573 9252-9255 DT denotes the
T8574 9266-9276 NN denotes mesenchyme
T8575 9256-9265 JJ denotes pulmonary
T8576 9276-9278 , denotes ,
T8577 9278-9280 IN denotes as
T8578 9285-9289 VBN denotes seen
T8579 9281-9284 VBD denotes was
T8580 9290-9300 RB denotes previously
T8581 9301-9305 IN denotes with
T8582 9306-9308 FW denotes in
T8583 9309-9313 FW denotes situ
T8584 9314-9327 NN denotes hybridization
T8585 9328-9330 IN denotes on
T8586 9331-9337 NN denotes tissue
T8587 9338-9346 NNS denotes sections
T8588 9346-9347 . denotes .
T8589 9347-9729 sentence denotes Figure 5 Fog2 Expression in Embryonic Non-Mutant Lungs In embryonic non-mutant lungs, Fog2 is most highly expressed at the tips of the accessory (single arrows) and right middle lobes (double arrows) at E11.25 (A) and E11.75 (B), while expression is diffuse by E12.75 (C). Diaphragms from Fog2 lil mice show an intact membrane with a defect in muscular patterning (see Figure 1B).
T8590 9622-9632 NNS denotes Diaphragms
T8591 9652-9656 VBP denotes show
T8592 9633-9637 IN denotes from
T8593 9638-9642 NN denotes Fog2
T8594 9647-9651 NNS denotes mice
T8595 9643-9646 NN denotes lil
T8596 9657-9659 DT denotes an
T8597 9667-9675 NN denotes membrane
T8598 9660-9666 JJ denotes intact
T8599 9676-9680 IN denotes with
T8600 9681-9682 DT denotes a
T8601 9683-9689 NN denotes defect
T8602 9690-9692 IN denotes in
T8603 9693-9701 JJ denotes muscular
T8604 9702-9712 NN denotes patterning
T8605 9713-9714 -LRB- denotes (
T8606 9714-9717 VB denotes see
T8607 9718-9724 NN denotes Figure
T8608 9725-9727 CD denotes 1B
T8609 9727-9728 -RRB- denotes )
T8610 9728-9729 . denotes .
T8611 9729-9864 sentence denotes The membranous portion of the diaphragm is populated by a migratory population of muscle precursor cells, much like the limbs [19,20].
T8612 9730-9733 DT denotes The
T8613 9745-9752 NN denotes portion
T8614 9734-9744 JJ denotes membranous
T8615 9773-9782 VBN denotes populated
T8616 9753-9755 IN denotes of
T8617 9756-9759 DT denotes the
T8618 9760-9769 NN denotes diaphragm
T8619 9770-9772 VBZ denotes is
T8620 9783-9785 IN denotes by
T8621 9786-9787 DT denotes a
T8622 9798-9808 NN denotes population
T8623 9788-9797 JJ denotes migratory
T8624 9809-9811 IN denotes of
T8625 9812-9818 NN denotes muscle
T8626 9829-9834 NNS denotes cells
T8627 9819-9828 NN denotes precursor
T8628 9834-9836 , denotes ,
T8629 9836-9840 RB denotes much
T8630 9841-9845 IN denotes like
T8631 9846-9849 DT denotes the
T8632 9850-9855 NNS denotes limbs
T8633 9856-9857 -LRB- denotes [
T8634 9860-9862 CD denotes 20
T8635 9857-9859 CD denotes 19
T8636 9859-9860 , denotes ,
T8637 9862-9863 -RRB- denotes ]
T8638 9863-9864 . denotes .
T8639 9864-9994 sentence denotes Mice with defects in genes known to be important for the control of this process have intact but amuscular diaphragms [17,21,22].
T8640 9865-9869 NNS denotes Mice
T8641 9946-9950 VBP denotes have
T8642 9870-9874 IN denotes with
T8643 9875-9882 NNS denotes defects
T8644 9883-9885 IN denotes in
T8645 9886-9891 NNS denotes genes
T8646 9892-9897 VBN denotes known
T8647 9898-9900 TO denotes to
T8648 9901-9903 VB denotes be
T8649 9904-9913 JJ denotes important
T8650 9914-9917 IN denotes for
T8651 9918-9921 DT denotes the
T8652 9922-9929 NN denotes control
T8653 9930-9932 IN denotes of
T8654 9933-9937 DT denotes this
T8655 9938-9945 NN denotes process
T8656 9951-9957 JJ denotes intact
T8657 9972-9982 NNS denotes diaphragms
T8658 9958-9961 CC denotes but
T8659 9962-9971 JJ denotes amuscular
T8660 9983-9984 -LRB- denotes [
T8661 9990-9992 CD denotes 22
T8662 9984-9986 CD denotes 17
T8663 9986-9987 , denotes ,
T8664 9987-9989 CD denotes 21
T8665 9989-9990 , denotes ,
T8666 9992-9993 -RRB- denotes ]
T8667 9993-9994 . denotes .
T8668 9994-10146 sentence denotes Hepatocyte growth factor/Scatter factor (HGF) is one potential candidate responsible for the guidance of muscle precursors to the membranous diaphragm.
T8669 9995-10005 NN denotes Hepatocyte
T8670 10013-10019 NN denotes factor
T8671 10006-10012 NN denotes growth
T8672 10041-10043 VBZ denotes is
T8673 10019-10020 HYPH denotes /
T8674 10020-10027 NN denotes Scatter
T8675 10028-10034 NN denotes factor
T8676 10035-10036 -LRB- denotes (
T8677 10036-10039 NN denotes HGF
T8678 10039-10040 -RRB- denotes )
T8679 10044-10047 CD denotes one
T8680 10058-10067 NN denotes candidate
T8681 10048-10057 JJ denotes potential
T8682 10068-10079 JJ denotes responsible
T8683 10080-10083 IN denotes for
T8684 10084-10087 DT denotes the
T8685 10088-10096 NN denotes guidance
T8686 10097-10099 IN denotes of
T8687 10100-10106 NN denotes muscle
T8688 10107-10117 NNS denotes precursors
T8689 10118-10120 IN denotes to
T8690 10121-10124 DT denotes the
T8691 10136-10145 NN denotes diaphragm
T8692 10125-10135 JJ denotes membranous
T8693 10145-10146 . denotes .
T8694 10146-10369 sentence denotes It has been shown that HGF is expressed along this anatomic pathway [23], and mice with absence of the HGF receptor c-Met fail to form muscularized pleuroperitoneal folds (PPFs), and thus have amuscular diaphragms [24,25].
T8695 10147-10149 PRP denotes It
T8696 10159-10164 VBN denotes shown
T8697 10150-10153 VBZ denotes has
T8698 10154-10158 VBN denotes been
T8699 10165-10169 IN denotes that
T8700 10177-10186 VBN denotes expressed
T8701 10170-10173 NN denotes HGF
T8702 10174-10176 VBZ denotes is
T8703 10187-10192 IN denotes along
T8704 10193-10197 DT denotes this
T8705 10207-10214 NN denotes pathway
T8706 10198-10206 JJ denotes anatomic
T8707 10215-10216 -LRB- denotes [
T8708 10216-10218 CD denotes 23
T8709 10218-10219 -RRB- denotes ]
T8710 10219-10221 , denotes ,
T8711 10221-10224 CC denotes and
T8712 10225-10229 NNS denotes mice
T8713 10269-10273 VBP denotes fail
T8714 10230-10234 IN denotes with
T8715 10235-10242 NN denotes absence
T8716 10243-10245 IN denotes of
T8717 10246-10249 DT denotes the
T8718 10254-10262 NN denotes receptor
T8719 10250-10253 NN denotes HGF
T8720 10263-10264 NN denotes c
T8721 10265-10268 NN denotes Met
T8722 10264-10265 HYPH denotes -
T8723 10274-10276 TO denotes to
T8724 10277-10281 VB denotes form
T8725 10282-10294 VBN denotes muscularized
T8726 10312-10317 NNS denotes folds
T8727 10295-10311 JJ denotes pleuroperitoneal
T8728 10318-10319 -LRB- denotes (
T8729 10319-10323 NNS denotes PPFs
T8730 10323-10324 -RRB- denotes )
T8731 10324-10326 , denotes ,
T8732 10326-10329 CC denotes and
T8733 10330-10334 RB denotes thus
T8734 10335-10339 VBP denotes have
T8735 10340-10349 JJ denotes amuscular
T8736 10350-10360 NNS denotes diaphragms
T8737 10361-10362 -LRB- denotes [
T8738 10365-10367 CD denotes 25
T8739 10362-10364 CD denotes 24
T8740 10364-10365 , denotes ,
T8741 10367-10368 -RRB- denotes ]
T8742 10368-10369 . denotes .
T8743 10369-10510 sentence denotes Fog2 is expressed diffusely in the early amuscular diaphragm at E11.5 as well as in the later muscularized diaphragm (see Figure 3C and 3D).
T8744 10370-10374 NN denotes Fog2
T8745 10378-10387 VBN denotes expressed
T8746 10375-10377 VBZ denotes is
T8747 10388-10397 RB denotes diffusely
T8748 10398-10400 IN denotes in
T8749 10401-10404 DT denotes the
T8750 10421-10430 NN denotes diaphragm
T8751 10405-10410 JJ denotes early
T8752 10411-10420 JJ denotes amuscular
T8753 10431-10433 IN denotes at
T8754 10434-10439 NN denotes E11.5
T8755 10440-10442 RB denotes as
T8756 10448-10450 IN denotes as
T8757 10443-10447 RB denotes well
T8758 10451-10453 IN denotes in
T8759 10454-10457 DT denotes the
T8760 10477-10486 NN denotes diaphragm
T8761 10458-10463 JJ denotes later
T8762 10464-10476 VBN denotes muscularized
T8763 10487-10488 -LRB- denotes (
T8764 10488-10491 VB denotes see
T8765 10492-10498 NN denotes Figure
T8766 10499-10501 CD denotes 3C
T8767 10502-10505 CC denotes and
T8768 10506-10508 CD denotes 3D
T8769 10508-10509 -RRB- denotes )
T8770 10509-10510 . denotes .
T8771 10510-10685 sentence denotes Pax3 and MyoD, transcription factors required for appropriate migration and determination of myogenic precursors, were detected in the PPFs of Fog2 lil mice (data not shown).
T8772 10511-10515 NN denotes Pax3
T8773 10630-10638 VBN denotes detected
T8774 10516-10519 CC denotes and
T8775 10520-10524 NN denotes MyoD
T8776 10524-10526 , denotes ,
T8777 10526-10539 NN denotes transcription
T8778 10540-10547 NNS denotes factors
T8779 10548-10556 VBN denotes required
T8780 10557-10560 IN denotes for
T8781 10561-10572 JJ denotes appropriate
T8782 10573-10582 NN denotes migration
T8783 10583-10586 CC denotes and
T8784 10587-10600 NN denotes determination
T8785 10601-10603 IN denotes of
T8786 10604-10612 JJ denotes myogenic
T8787 10613-10623 NNS denotes precursors
T8788 10623-10625 , denotes ,
T8789 10625-10629 VBD denotes were
T8790 10639-10641 IN denotes in
T8791 10642-10645 DT denotes the
T8792 10646-10650 NNS denotes PPFs
T8793 10651-10653 IN denotes of
T8794 10654-10658 NN denotes Fog2
T8795 10663-10667 NNS denotes mice
T8796 10659-10662 NN denotes lil
T8797 10668-10669 -LRB- denotes (
T8798 10678-10683 VBN denotes shown
T8799 10669-10673 NNS denotes data
T8800 10674-10677 RB denotes not
T8801 10683-10684 -RRB- denotes )
T8802 10684-10685 . denotes .
T8803 10685-10881 sentence denotes However, in situ expression analysis demonstrated that the expression of HGF in the region where this structure meets the membranous diaphragm was markedly reduced in Fog2 mutant mice (Figure 6).
T8804 10686-10693 RB denotes However
T8805 10723-10735 VBD denotes demonstrated
T8806 10693-10695 , denotes ,
T8807 10695-10697 FW denotes in
T8808 10698-10702 FW denotes situ
T8809 10714-10722 NN denotes analysis
T8810 10703-10713 NN denotes expression
T8811 10736-10740 IN denotes that
T8812 10842-10849 VBN denotes reduced
T8813 10741-10744 DT denotes the
T8814 10745-10755 NN denotes expression
T8815 10756-10758 IN denotes of
T8816 10759-10762 NN denotes HGF
T8817 10763-10765 IN denotes in
T8818 10766-10769 DT denotes the
T8819 10770-10776 NN denotes region
T8820 10777-10782 WRB denotes where
T8821 10798-10803 VBZ denotes meets
T8823 10788-10797 NN denotes structure
T8824 10804-10807 DT denotes the
T8825 10819-10828 NN denotes diaphragm
T8826 10808-10818 JJ denotes membranous
T8827 10829-10832 VBD denotes was
T8828 10833-10841 RB denotes markedly
T8829 10850-10852 IN denotes in
T8830 10853-10857 NN denotes Fog2
T8831 10865-10869 NNS denotes mice
T8832 10858-10864 NN denotes mutant
T8833 10870-10871 -LRB- denotes (
T8834 10871-10877 NN denotes Figure
T8835 10878-10879 CD denotes 6
T8836 10879-10880 -RRB- denotes )
T8837 10880-10881 . denotes .
T8838 10881-11175 sentence denotes We hypothesize that Fog2 is required (either directly or indirectly) for the induction of HGF in the developing diaphragm, and dysregulation of HGF patterning along the path of muscle precursor cell migration between the PPF and the diaphragm accounts for the abnormal phenotype in these mice.
T8839 10882-10884 PRP denotes We
T8840 10885-10896 VBP denotes hypothesize
T8841 10897-10901 IN denotes that
T8842 10910-10918 VBN denotes required
T8843 10902-10906 NN denotes Fog2
T8844 10907-10909 VBZ denotes is
T8845 10919-10920 -LRB- denotes (
T8846 10920-10926 CC denotes either
T8847 10927-10935 RB denotes directly
T8848 10936-10938 CC denotes or
T8849 10939-10949 RB denotes indirectly
T8850 10949-10950 -RRB- denotes )
T8851 10951-10954 IN denotes for
T8852 10955-10958 DT denotes the
T8853 10959-10968 NN denotes induction
T8854 10969-10971 IN denotes of
T8855 10972-10975 NN denotes HGF
T8856 10976-10978 IN denotes in
T8857 10979-10982 DT denotes the
T8858 10994-11003 NN denotes diaphragm
T8859 10983-10993 VBG denotes developing
T8860 11003-11005 , denotes ,
T8861 11005-11008 CC denotes and
T8862 11009-11022 NN denotes dysregulation
T8863 11125-11133 VBZ denotes accounts
T8864 11023-11025 IN denotes of
T8865 11026-11029 NN denotes HGF
T8866 11030-11040 NN denotes patterning
T8867 11041-11046 IN denotes along
T8868 11047-11050 DT denotes the
T8869 11051-11055 NN denotes path
T8870 11056-11058 IN denotes of
T8871 11059-11065 NN denotes muscle
T8872 11076-11080 NN denotes cell
T8873 11066-11075 NN denotes precursor
T8874 11081-11090 NN denotes migration
T8875 11091-11098 IN denotes between
T8876 11099-11102 DT denotes the
T8877 11103-11106 NN denotes PPF
T8878 11107-11110 CC denotes and
T8879 11111-11114 DT denotes the
T8880 11115-11124 NN denotes diaphragm
T8881 11134-11137 IN denotes for
T8882 11138-11141 DT denotes the
T8883 11151-11160 NN denotes phenotype
T8884 11142-11150 JJ denotes abnormal
T8885 11161-11163 IN denotes in
T8886 11164-11169 DT denotes these
T8887 11170-11174 NNS denotes mice
T8888 11174-11175 . denotes .
T9907 11424-11428 NN denotes FOG2
T9908 11429-11437 NN denotes Mutation
T9909 11438-11440 IN denotes in
T9910 11441-11442 DT denotes a
T9911 11443-11450 NN denotes Patient
T9912 11451-11455 IN denotes with
T9913 11456-11465 NN denotes Diaphragm
T9914 11475-11488 NNS denotes Abnormalities
T9915 11466-11469 CC denotes and
T9916 11470-11474 NN denotes Lung
T9917 11488-11712 sentence denotes FOG2 sequence analysis was performed on autopsy tissue from 30 of 32 deceased children with an anatomic diagnosis of diaphragmatic defect evaluated at the Children's Hospital in Boston, Massachusetts, between 1993 and 2003.
T9918 11489-11493 NN denotes FOG2
T9919 11503-11511 NN denotes analysis
T9920 11494-11502 NN denotes sequence
T9921 11516-11525 VBN denotes performed
T9922 11512-11515 VBD denotes was
T9923 11526-11528 IN denotes on
T9924 11529-11536 NN denotes autopsy
T9925 11537-11543 NN denotes tissue
T9926 11544-11548 IN denotes from
T9927 11549-11551 CD denotes 30
T9928 11555-11557 CD denotes 32
T9929 11552-11554 IN denotes of
T9930 11567-11575 NNS denotes children
T9931 11558-11566 VBN denotes deceased
T9932 11576-11580 IN denotes with
T9933 11581-11583 DT denotes an
T9934 11593-11602 NN denotes diagnosis
T9935 11584-11592 JJ denotes anatomic
T9936 11603-11605 IN denotes of
T9937 11606-11619 JJ denotes diaphragmatic
T9938 11620-11626 NN denotes defect
T9939 11627-11636 VBN denotes evaluated
T9940 11637-11639 IN denotes at
T9941 11640-11643 DT denotes the
T9942 11655-11663 NNP denotes Hospital
T9943 11644-11652 NNPS denotes Children
T9944 11652-11654 POS denotes 's
T9945 11664-11666 IN denotes in
T9946 11667-11673 NNP denotes Boston
T9947 11673-11675 , denotes ,
T9948 11675-11688 NNP denotes Massachusetts
T9949 11688-11690 , denotes ,
T9950 11690-11697 IN denotes between
T9951 11698-11702 CD denotes 1993
T9952 11703-11706 CC denotes and
T9953 11707-11711 CD denotes 2003
T9954 11711-11712 . denotes .
T9955 11712-11779 sentence denotes Autopsy reports were reviewed to determine the specific diagnoses.
T9956 11713-11720 NN denotes Autopsy
T9957 11721-11728 NNS denotes reports
T9958 11734-11742 VBN denotes reviewed
T9959 11729-11733 VBD denotes were
T9960 11743-11745 TO denotes to
T9961 11746-11755 VB denotes determine
T9962 11756-11759 DT denotes the
T9963 11769-11778 NNS denotes diagnoses
T9964 11760-11768 JJ denotes specific
T9965 11778-11779 . denotes .
T9966 11779-12041 sentence denotes Of these 30 cases, 17 (57%) had Bochdalek CDH, two (7%) had diaphragmatic agenesis, seven (23%) had diaphragmatic eventration/muscularization defects (without Bochdalek CDH), and four (13%) had Bochdalek hernia of one hemidiaphragm and eventration of the other.
T9967 11780-11782 IN denotes Of
T9968 11808-11811 VBD denotes had
T9969 11783-11788 DT denotes these
T9970 11792-11797 NNS denotes cases
T9971 11789-11791 CD denotes 30
T9972 11797-11799 , denotes ,
T9973 11799-11801 CD denotes 17
T9974 11802-11803 -LRB- denotes (
T9975 11805-11806 NN denotes %
T9976 11803-11805 CD denotes 57
T9977 11806-11807 -RRB- denotes )
T9978 11812-11821 NNP denotes Bochdalek
T9979 11822-11825 NN denotes CDH
T9980 11825-11827 , denotes ,
T9981 11827-11830 CD denotes two
T9982 11836-11839 VBD denotes had
T9983 11831-11832 -LRB- denotes (
T9984 11833-11834 NN denotes %
T9985 11832-11833 CD denotes 7
T9986 11834-11835 -RRB- denotes )
T9987 11840-11853 JJ denotes diaphragmatic
T9988 11854-11862 NN denotes agenesis
T9989 11862-11864 , denotes ,
T9990 11864-11869 CD denotes seven
T9991 11876-11879 VBD denotes had
T9992 11870-11871 -LRB- denotes (
T9993 11873-11874 NN denotes %
T9994 11871-11873 CD denotes 23
T9995 11874-11875 -RRB- denotes )
T9996 11880-11893 JJ denotes diaphragmatic
T9997 11894-11905 NN denotes eventration
T9998 11905-11906 HYPH denotes /
T9999 11906-11921 NN denotes muscularization
T10000 11922-11929 NNS denotes defects
T10001 11930-11931 -LRB- denotes (
T10002 11931-11938 IN denotes without
T10003 11939-11948 NNP denotes Bochdalek
T10004 11949-11952 NN denotes CDH
T10005 11952-11953 -RRB- denotes )
T10006 11953-11955 , denotes ,
T10007 11955-11958 CC denotes and
T10008 11959-11963 CD denotes four
T10009 11970-11973 VBD denotes had
T10010 11964-11965 -LRB- denotes (
T10011 11967-11968 NN denotes %
T10012 11965-11967 CD denotes 13
T10013 11968-11969 -RRB- denotes )
T10014 11974-11983 NNP denotes Bochdalek
T10015 11984-11990 NN denotes hernia
T10016 11991-11993 IN denotes of
T10017 11994-11997 CD denotes one
T10018 11998-12011 NN denotes hemidiaphragm
T10019 12012-12015 CC denotes and
T10020 12016-12027 NN denotes eventration
T10021 12028-12030 IN denotes of
T10022 12031-12034 DT denotes the
T10023 12035-12040 NN denotes other
T10024 12040-12041 . denotes .
T10025 12041-12137 sentence denotes Pulmonary hypoplasia was assessed using lung/body weight ratio and radial alveolar counts [26].
T10026 12042-12051 JJ denotes Pulmonary
T10027 12052-12062 NN denotes hypoplasia
T10028 12067-12075 VBN denotes assessed
T10029 12063-12066 VBD denotes was
T10030 12076-12081 VBG denotes using
T10031 12082-12086 NN denotes lung
T10032 12087-12091 NN denotes body
T10033 12086-12087 HYPH denotes /
T10034 12099-12104 NN denotes ratio
T10035 12092-12098 NN denotes weight
T10036 12105-12108 CC denotes and
T10037 12109-12115 JJ denotes radial
T10038 12125-12131 NNS denotes counts
T10039 12116-12124 JJ denotes alveolar
T10040 12132-12133 -LRB- denotes [
T10041 12133-12135 CD denotes 26
T10042 12135-12136 -RRB- denotes ]
T10043 12136-12137 . denotes .
T10044 12137-12275 sentence denotes The material available for review included written reports and histologic slides in all cases and gross kodachromes in a subset of cases.
T10045 12138-12141 DT denotes The
T10046 12142-12150 NN denotes material
T10047 12172-12180 VBN denotes included
T10048 12151-12160 JJ denotes available
T10049 12161-12164 IN denotes for
T10050 12165-12171 NN denotes review
T10051 12181-12188 VBN denotes written
T10052 12189-12196 NNS denotes reports
T10053 12197-12200 CC denotes and
T10054 12201-12211 JJ denotes histologic
T10055 12212-12218 NNS denotes slides
T10056 12219-12221 IN denotes in
T10057 12222-12225 DT denotes all
T10058 12226-12231 NNS denotes cases
T10059 12232-12235 CC denotes and
T10060 12236-12241 JJ denotes gross
T10061 12242-12253 NNS denotes kodachromes
T10062 12254-12256 IN denotes in
T10063 12257-12258 DT denotes a
T10064 12259-12265 NN denotes subset
T10065 12266-12268 IN denotes of
T10066 12269-12274 NNS denotes cases
T10067 12274-12275 . denotes .
T10068 12275-12336 sentence denotes One child carried a highly significant FOG2 sequence change.
T10069 12276-12279 CD denotes One
T10070 12280-12285 NN denotes child
T10071 12286-12293 VBD denotes carried
T10072 12294-12295 DT denotes a
T10073 12329-12335 NN denotes change
T10074 12296-12302 RB denotes highly
T10075 12303-12314 JJ denotes significant
T10076 12315-12319 NN denotes FOG2
T10077 12320-12328 NN denotes sequence
T10078 12335-12336 . denotes .
T10079 12336-12469 sentence denotes The patient was a full-term 3,500-g baby girl who developed severe respiratory failure at birth and died after 5 h of resuscitation.
T10080 12337-12340 DT denotes The
T10081 12341-12348 NN denotes patient
T10082 12349-12352 VBD denotes was
T10083 12353-12354 DT denotes a
T10084 12378-12382 NN denotes girl
T10085 12355-12359 JJ denotes full
T10086 12360-12364 NN denotes term
T10087 12359-12360 HYPH denotes -
T10088 12365-12370 CD denotes 3,500
T10089 12371-12372 NN denotes g
T10090 12370-12371 HYPH denotes -
T10091 12373-12377 NN denotes baby
T10092 12383-12386 WP denotes who
T10093 12387-12396 VBD denotes developed
T10094 12397-12403 JJ denotes severe
T10095 12416-12423 NN denotes failure
T10096 12404-12415 JJ denotes respiratory
T10097 12424-12426 IN denotes at
T10098 12427-12432 NN denotes birth
T10099 12433-12436 CC denotes and
T10100 12437-12441 VBD denotes died
T10101 12442-12447 IN denotes after
T10102 12448-12449 CD denotes 5
T10103 12450-12451 NN denotes h
T10104 12452-12454 IN denotes of
T10105 12455-12468 NN denotes resuscitation
T10106 12468-12469 . denotes .
T10107 12469-12554 sentence denotes Antemortem radiographs showed opacified lung fields and possible bowel in the chest.
T10108 12470-12480 NN denotes Antemortem
T10109 12481-12492 NNS denotes radiographs
T10110 12493-12499 VBD denotes showed
T10111 12500-12509 VBN denotes opacified
T10112 12515-12521 NNS denotes fields
T10113 12510-12514 NN denotes lung
T10114 12522-12525 CC denotes and
T10115 12526-12534 JJ denotes possible
T10116 12535-12540 NN denotes bowel
T10117 12541-12543 IN denotes in
T10118 12544-12547 DT denotes the
T10119 12548-12553 NN denotes chest
T10120 12553-12554 . denotes .
T10121 12554-12596 sentence denotes The patient's clinical diagnosis was CDH.
T10122 12555-12558 DT denotes The
T10123 12559-12566 NN denotes patient
T10124 12578-12587 NN denotes diagnosis
T10125 12566-12568 POS denotes 's
T10126 12569-12577 JJ denotes clinical
T10127 12588-12591 VBD denotes was
T10128 12592-12595 NN denotes CDH
T10129 12595-12596 . denotes .
T10130 12596-12795 sentence denotes Review of autopsy material revealed severe bilateral pulmonary hypoplasia (combined lung weight, 11.1 g; expected for body length/weight, 46.8 ± 26.2 g; [27]), most markedly involving the left lung.
T10131 12597-12603 NN denotes Review
T10132 12624-12632 VBD denotes revealed
T10133 12604-12606 IN denotes of
T10134 12607-12614 NN denotes autopsy
T10135 12615-12623 NN denotes material
T10136 12633-12639 JJ denotes severe
T10137 12660-12670 NN denotes hypoplasia
T10138 12640-12649 JJ denotes bilateral
T10139 12650-12659 JJ denotes pulmonary
T10140 12671-12672 -LRB- denotes (
T10141 12751-12753 CD denotes 27
T10142 12672-12680 VBN denotes combined
T10143 12686-12692 NN denotes weight
T10144 12681-12685 NN denotes lung
T10145 12699-12700 NN denotes g
T10146 12692-12694 , denotes ,
T10147 12694-12698 CD denotes 11.1
T10148 12700-12701 : denotes ;
T10149 12702-12710 VBN denotes expected
T10150 12711-12714 IN denotes for
T10151 12715-12719 NN denotes body
T10152 12727-12733 NN denotes weight
T10153 12720-12726 NN denotes length
T10154 12726-12727 HYPH denotes /
T10155 12733-12735 , denotes ,
T10156 12735-12739 CD denotes 46.8
T10157 12742-12746 CD denotes 26.2
T10158 12740-12741 SYM denotes ±
T10159 12747-12748 NN denotes g
T10160 12748-12749 : denotes ;
T10161 12750-12751 -LRB- denotes [
T10162 12753-12754 -RRB- denotes ]
T10163 12754-12755 -RRB- denotes )
T10164 12755-12757 , denotes ,
T10165 12757-12761 RBS denotes most
T10166 12762-12770 RB denotes markedly
T10167 12771-12780 VBG denotes involving
T10168 12781-12784 DT denotes the
T10169 12790-12794 NN denotes lung
T10170 12785-12789 JJ denotes left
T10171 12794-12795 . denotes .
T10172 12795-12858 sentence denotes The lung/body weight ratio was 0.0037 (expected > 0.010) [28].
T10173 12796-12799 DT denotes The
T10174 12817-12822 NN denotes ratio
T10175 12800-12804 NN denotes lung
T10176 12804-12805 SYM denotes /
T10177 12805-12809 NN denotes body
T10178 12810-12816 NN denotes weight
T10179 12823-12826 VBD denotes was
T10180 12827-12833 CD denotes 0.0037
T10181 12834-12835 -LRB- denotes (
T10182 12846-12851 CD denotes 0.010
T10183 12835-12843 VBN denotes expected
T10184 12844-12845 SYM denotes >
T10185 12851-12852 -RRB- denotes )
T10186 12853-12854 -LRB- denotes [
T10187 12854-12856 CD denotes 28
T10188 12856-12857 -RRB- denotes ]
T10189 12857-12858 . denotes .
T10190 12858-12971 sentence denotes There were a reduced number of bronchial generations, and the radial alveolar count was 2–3 (expected = 5) [29].
T10191 12859-12864 EX denotes There
T10192 12865-12869 VBD denotes were
T10193 12870-12871 DT denotes a
T10194 12880-12886 NN denotes number
T10195 12872-12879 VBN denotes reduced
T10196 12887-12889 IN denotes of
T10197 12890-12899 JJ denotes bronchial
T10198 12900-12911 NNS denotes generations
T10199 12911-12913 , denotes ,
T10200 12913-12916 CC denotes and
T10201 12917-12920 DT denotes the
T10202 12937-12942 NN denotes count
T10203 12921-12927 JJ denotes radial
T10204 12928-12936 JJ denotes alveolar
T10205 12943-12946 VBD denotes was
T10206 12947-12948 CD denotes 2
T10207 12949-12950 CD denotes 3
T10208 12948-12949 SYM denotes –
T10209 12951-12952 -LRB- denotes (
T10210 12963-12964 CD denotes 5
T10211 12952-12960 VBN denotes expected
T10212 12961-12962 SYM denotes =
T10213 12964-12965 -RRB- denotes )
T10214 12966-12967 -LRB- denotes [
T10215 12967-12969 CD denotes 29
T10216 12969-12970 -RRB- denotes ]
T10217 12970-12971 . denotes .
T10218 12971-13020 sentence denotes There were incomplete lung fissures bilaterally.
T10219 12972-12977 EX denotes There
T10220 12978-12982 VBD denotes were
T10221 12983-12993 JJ denotes incomplete
T10222 12999-13007 NNS denotes fissures
T10223 12994-12998 NN denotes lung
T10224 13008-13019 RB denotes bilaterally
T10225 13019-13020 . denotes .
T10226 13020-13093 sentence denotes A deep posterior diaphragmatic eventration was present on the left side.
T10227 13021-13022 DT denotes A
T10228 13052-13063 NN denotes eventration
T10229 13023-13027 JJ denotes deep
T10230 13028-13037 JJ denotes posterior
T10231 13038-13051 JJ denotes diaphragmatic
T10232 13064-13067 VBD denotes was
T10233 13068-13075 JJ denotes present
T10234 13076-13078 IN denotes on
T10235 13079-13082 DT denotes the
T10236 13088-13092 NN denotes side
T10237 13083-13087 JJ denotes left
T10238 13092-13093 . denotes .
T10239 13093-13259 sentence denotes Additionally, two muscularized ligamentous bands resembling diaphragmatic remnants encircled the left lobe of the liver, creating an abnormal fissured liver contour.
T10240 13094-13106 RB denotes Additionally
T10241 13177-13186 VBD denotes encircled
T10242 13106-13108 , denotes ,
T10243 13108-13111 CD denotes two
T10244 13137-13142 NNS denotes bands
T10245 13112-13124 VBN denotes muscularized
T10246 13125-13136 JJ denotes ligamentous
T10247 13143-13153 VBG denotes resembling
T10248 13154-13167 JJ denotes diaphragmatic
T10249 13168-13176 NNS denotes remnants
T10250 13187-13190 DT denotes the
T10251 13196-13200 NN denotes lobe
T10252 13191-13195 JJ denotes left
T10253 13201-13203 IN denotes of
T10254 13204-13207 DT denotes the
T10255 13208-13213 NN denotes liver
T10256 13213-13215 , denotes ,
T10257 13215-13223 VBG denotes creating
T10258 13224-13226 DT denotes an
T10259 13251-13258 NN denotes contour
T10260 13227-13235 JJ denotes abnormal
T10261 13236-13244 VBN denotes fissured
T10262 13245-13250 NN denotes liver
T10263 13258-13259 . denotes .
T10264 13259-13359 sentence denotes Away from the eventration, the diaphragm appeared well muscularized, measuring 0.3 cm in thickness.
T10265 13260-13264 RB denotes Away
T10266 13301-13309 VBD denotes appeared
T10267 13265-13269 IN denotes from
T10268 13270-13273 DT denotes the
T10269 13274-13285 NN denotes eventration
T10270 13285-13287 , denotes ,
T10271 13287-13290 DT denotes the
T10272 13291-13300 NN denotes diaphragm
T10273 13310-13314 RB denotes well
T10274 13315-13327 VBN denotes muscularized
T10275 13327-13329 , denotes ,
T10276 13329-13338 VBG denotes measuring
T10277 13339-13342 CD denotes 0.3
T10278 13343-13345 NN denotes cm
T10279 13346-13348 IN denotes in
T10280 13349-13358 NN denotes thickness
T10281 13358-13359 . denotes .
T10282 13359-13492 sentence denotes A complete autopsy revealed no other malformations; the heart was determined to be grossly normal and was donated for valve harvest.
T10283 13360-13361 DT denotes A
T10284 13371-13378 NN denotes autopsy
T10285 13362-13370 JJ denotes complete
T10286 13379-13387 VBD denotes revealed
T10287 13426-13436 VBN denotes determined
T10288 13388-13390 DT denotes no
T10289 13397-13410 NNS denotes malformations
T10290 13391-13396 JJ denotes other
T10291 13410-13411 : denotes ;
T10292 13412-13415 DT denotes the
T10293 13416-13421 NN denotes heart
T10294 13422-13425 VBD denotes was
T10295 13437-13439 TO denotes to
T10296 13440-13442 VB denotes be
T10297 13443-13450 RB denotes grossly
T10298 13451-13457 JJ denotes normal
T10299 13458-13461 CC denotes and
T10300 13462-13465 VBD denotes was
T10301 13466-13473 VBN denotes donated
T10302 13474-13477 IN denotes for
T10303 13478-13483 NN denotes valve
T10304 13484-13491 NN denotes harvest
T10305 13491-13492 . denotes .
T10306 13492-13636 sentence denotes Sequence analysis revealed a cytosine to thymine heterozygous change in exon 4 that changes the 112th amino acid from arginine to a stop codon.
T10307 13493-13501 NN denotes Sequence
T10308 13502-13510 NN denotes analysis
T10309 13511-13519 VBD denotes revealed
T10310 13520-13521 DT denotes a
T10311 13555-13561 NN denotes change
T10312 13522-13530 NN denotes cytosine
T10313 13531-13533 IN denotes to
T10314 13534-13541 NN denotes thymine
T10315 13542-13554 JJ denotes heterozygous
T10316 13562-13564 IN denotes in
T10317 13565-13569 NN denotes exon
T10318 13570-13571 CD denotes 4
T10319 13572-13576 WDT denotes that
T10320 13577-13584 VBZ denotes changes
T10321 13585-13588 DT denotes the
T10322 13601-13605 NN denotes acid
T10323 13589-13594 JJ denotes 112th
T10324 13595-13600 NN denotes amino
T10325 13606-13610 IN denotes from
T10326 13611-13619 NN denotes arginine
T10327 13620-13622 IN denotes to
T10328 13623-13624 DT denotes a
T10329 13630-13635 NN denotes codon
T10330 13625-13629 NN denotes stop
T10331 13635-13636 . denotes .
T10332 13636-13742 sentence denotes This mutation produces a severely truncated peptide that does not contain zinc finger domains (Figure 7).
T10333 13637-13641 DT denotes This
T10334 13642-13650 NN denotes mutation
T10335 13651-13659 VBZ denotes produces
T10336 13660-13661 DT denotes a
T10337 13681-13688 NN denotes peptide
T10338 13662-13670 RB denotes severely
T10339 13671-13680 VBN denotes truncated
T10340 13689-13693 WDT denotes that
T10341 13703-13710 VB denotes contain
T10342 13694-13698 VBZ denotes does
T10343 13699-13702 RB denotes not
T10344 13711-13715 NN denotes zinc
T10345 13716-13722 NN denotes finger
T10346 13723-13730 NNS denotes domains
T10347 13731-13732 -LRB- denotes (
T10348 13732-13738 NN denotes Figure
T10349 13739-13740 CD denotes 7
T10350 13740-13741 -RRB- denotes )
T10351 13741-13742 . denotes .
T10352 13742-13822 sentence denotes This base change was not present in the analysis of DNA from 400 normal adults.
T10353 13743-13747 DT denotes This
T10354 13753-13759 NN denotes change
T10355 13748-13752 NN denotes base
T10356 13760-13763 VBD denotes was
T10357 13764-13767 RB denotes not
T10358 13768-13775 JJ denotes present
T10359 13776-13778 IN denotes in
T10360 13779-13782 DT denotes the
T10361 13783-13791 NN denotes analysis
T10362 13792-13794 IN denotes of
T10363 13795-13798 NN denotes DNA
T10364 13799-13803 IN denotes from
T10365 13804-13807 CD denotes 400
T10366 13815-13821 NNS denotes adults
T10367 13808-13814 JJ denotes normal
T10368 13821-13822 . denotes .
T10369 13822-13935 sentence denotes To assess the likelihood that the mutation was causal for the developmental phenotype, we examined both parents.
T10370 13823-13825 TO denotes To
T10371 13826-13832 VB denotes assess
T10372 13913-13921 VBD denotes examined
T10373 13833-13836 DT denotes the
T10374 13837-13847 NN denotes likelihood
T10375 13848-13852 IN denotes that
T10376 13866-13869 VBD denotes was
T10377 13853-13856 DT denotes the
T10378 13857-13865 NN denotes mutation
T10379 13870-13876 JJ denotes causal
T10380 13877-13880 IN denotes for
T10381 13881-13884 DT denotes the
T10382 13899-13908 NN denotes phenotype
T10383 13885-13898 JJ denotes developmental
T10384 13908-13910 , denotes ,
T10385 13910-13912 PRP denotes we
T10386 13922-13926 DT denotes both
T10387 13927-13934 NNS denotes parents
T10388 13934-13935 . denotes .
T10389 13935-14106 sentence denotes Paternity was confirmed, and sequence analysis revealed that the neither parent carried this mutation, proving that the patient had a de novo mutation in FOG2 (Figure 7).
T10390 13936-13945 NN denotes Paternity
T10391 13950-13959 VBN denotes confirmed
T10392 13946-13949 VBD denotes was
T10393 13959-13961 , denotes ,
T10394 13961-13964 CC denotes and
T10395 13965-13973 NN denotes sequence
T10396 13974-13982 NN denotes analysis
T10397 13983-13991 VBD denotes revealed
T10398 13992-13996 IN denotes that
T10399 14016-14023 VBD denotes carried
T10400 13997-14000 DT denotes the
T10401 14009-14015 NN denotes parent
T10402 14001-14008 CC denotes neither
T10403 14024-14028 DT denotes this
T10404 14029-14037 NN denotes mutation
T10405 14037-14039 , denotes ,
T10406 14039-14046 VBG denotes proving
T10407 14047-14051 IN denotes that
T10408 14064-14067 VBD denotes had
T10409 14052-14055 DT denotes the
T10410 14056-14063 NN denotes patient
T10411 14068-14069 DT denotes a
T10412 14078-14086 NN denotes mutation
T10413 14070-14072 FW denotes de
T10414 14073-14077 FW denotes novo
T10415 14087-14089 IN denotes in
T10416 14090-14094 NN denotes FOG2
T10417 14095-14096 -LRB- denotes (
T10418 14096-14102 NN denotes Figure
T10419 14103-14104 CD denotes 7
T10420 14104-14105 -RRB- denotes )
T10421 14105-14106 . denotes .
R839 T5357 T5356 prep of,Identification
R840 T5358 T5359 det the,Mutation
R841 T5359 T5357 pobj Mutation,of
R842 T5360 T5361 amod little,lung
R843 T5361 T5359 compound lung,Mutation
R844 T5362 T5356 prep in,Identification
R845 T5363 T5362 pobj Fog2,in
R846 T5365 T5366 nsubj We,screened
R847 T5367 T5368 amod third,generation
R848 T5368 T5370 compound generation,progeny
R849 T5369 T5368 punct -,generation
R850 T5370 T5366 dobj progeny,screened
R851 T5371 T5370 prep of,progeny
R852 T5372 T5373 npadvmod ENU,mutagenized
R853 T5373 T5375 amod mutagenized,mice
R854 T5374 T5373 punct -,mutagenized
R855 T5375 T5371 pobj mice,of
R856 T5376 T5366 prep at,screened
R857 T5377 T5378 amod embryonic,day
R858 T5378 T5376 pobj day,at
R859 T5379 T5378 nummod 18.5,day
R860 T5380 T5378 punct (,day
R861 T5381 T5378 appos E18.5,day
R862 T5382 T5366 punct ),screened
R863 T5383 T5366 prep for,screened
R864 T5384 T5385 amod abnormal,phenotypes
R865 T5385 T5383 pobj phenotypes,for
R866 T5386 T5385 amod developmental,phenotypes
R867 T5387 T5388 punct [,14
R868 T5388 T5366 parataxis 14,screened
R869 T5389 T5388 punct ],14
R870 T5390 T5366 punct .,screened
R871 T5392 T5393 nummod One,line
R872 T5393 T5394 nsubjpass line,found
R873 T5395 T5393 prep of,line
R874 T5396 T5395 pobj mice,of
R875 T5397 T5394 auxpass was,found
R876 T5398 T5399 aux to,have
R877 T5399 T5394 xcomp have,found
R878 T5400 T5401 amod multiple,embryos
R879 T5401 T5399 dobj embryos,have
R880 T5402 T5401 prep in,embryos
R881 T5403 T5404 amod independent,litters
R882 T5404 T5402 pobj litters,in
R883 T5405 T5406 dep that,displayed
R884 T5406 T5401 relcl displayed,embryos
R885 T5407 T5408 amod pulmonary,hypoplasia
R886 T5408 T5406 dobj hypoplasia,displayed
R887 T5409 T5408 cc and,hypoplasia
R888 T5410 T5411 det a,diaphragm
R889 T5411 T5408 conj diaphragm,hypoplasia
R890 T5412 T5411 amod thin,diaphragm
R891 T5413 T5394 punct .,found
R892 T5415 T5416 det The,mutation
R893 T5416 T5417 nsubjpass mutation,mapped
R894 T5418 T5416 punct ", ",mutation
R895 T5419 T5420 dep which,called
R896 T5420 T5416 relcl called,mutation
R897 T5421 T5420 nsubj we,called
R898 T5422 T5423 amod little,lung
R899 T5423 T5420 oprd lung,called
R900 T5424 T5423 punct (,lung
R901 T5425 T5423 appos lil,lung
R902 T5426 T5423 punct ),lung
R903 T5427 T5417 punct ", ",mapped
R904 T5428 T5417 auxpass was,mapped
R905 T5429 T5417 prep to,mapped
R906 T5430 T5429 pobj Chromosome,to
R907 T5431 T5430 nummod 15,Chromosome
R908 T5432 T5417 prep by,mapped
R909 T5433 T5432 pcomp utilizing,by
R910 T5434 T5435 det a,strategy
R911 T5435 T5433 dobj strategy,utilizing
R912 T5442 T5441 nsubj data,shown
R913 T5436 T5435 prep of,strategy
R914 T5443 T5441 neg not,shown
R915 T5444 T5441 punct ),shown
R916 T5437 T5438 amod interval,analysis
R917 T5445 T5446 punct [,15
R918 T5446 T5417 parataxis 15,mapped
R919 T5438 T5436 pobj analysis,of
R920 T5447 T5446 punct ],15
R921 T5448 T5417 punct .,mapped
R922 T5439 T5438 compound haplotype,analysis
R923 T5450 T5451 prep For,analyzed
R924 T5440 T5441 punct (,shown
R925 T5452 T5453 amod high,resolution
R926 T5441 T5417 parataxis shown,mapped
R927 T5453 T5455 compound resolution,mapping
R928 T5454 T5453 punct -,resolution
R929 T5455 T5450 pobj mapping,For
R930 T5548 T5549 compound flanking,markers
R931 T5456 T5451 punct ", ",analyzed
R932 T5457 T5458 compound F2,progeny
R933 T5458 T5451 nsubjpass progeny,analyzed
R934 T5549 T5544 dobj markers,D15Mit5
R935 T5459 T5458 prep from,progeny
R936 T5460 T5461 nummod two,crosses
R937 T5461 T5459 pobj crosses,from
R938 T5550 T5535 punct .,established
R939 T5462 T5451 auxpass were,analyzed
R940 T5463 T5451 punct .,analyzed
R941 T5465 T5466 prep In,defined
R942 T5552 T5553 det The,phenotype
R943 T5467 T5468 nummod 450,progeny
R944 T5468 T5465 pobj progeny,In
R945 T5469 T5468 prep of,progeny
R946 T5470 T5471 det an,intercross
R947 T5553 T5555 nsubjpass phenotype,identified
R948 T5471 T5469 pobj intercross,of
R949 T5472 T5471 prep of,intercross
R950 T5473 T5474 nmod F1,mice
R951 T5554 T5553 compound lil,phenotype
R952 T5474 T5472 pobj mice,of
R953 T5475 T5476 punct (,J
R954 T5556 T5555 auxpass was,identified
R955 T5476 T5474 nmod J,mice
R956 T5477 T5476 nmod A,J
R957 T5478 T5476 punct /,J
R958 T5479 T5476 punct ×,J
R959 T5480 T5481 compound FVB,N
R960 T5481 T5476 appos N,J
R961 T5557 T5555 prep at,identified
R962 T5482 T5481 punct /,N
R963 T5483 T5476 punct ),J
R964 T5484 T5474 nmod lil,mice
R965 T5485 T5484 punct /,lil
R966 T5558 T5557 pobj E18.5,at
R967 T5486 T5484 punct +,lil
R968 T5487 T5466 punct ", ",defined
R969 T5488 T5489 det the,interval
R970 T5559 T5560 aux to,have
R971 T5489 T5466 nsubjpass interval,defined
R972 T5490 T5489 acl containing,interval
R973 T5491 T5492 det the,mutation
R974 T5560 T5555 xcomp have,identified
R975 T5492 T5490 dobj mutation,containing
R976 T5493 T5466 auxpass was,defined
R977 T5494 T5466 prep by,defined
R978 T5561 T5562 amod bilateral,hypoplasia
R979 T5495 T5496 nummod 19,recombinants
R980 T5496 T5494 pobj recombinants,by
R981 T5497 T5496 prep between,recombinants
R982 T5562 T5560 dobj hypoplasia,have
R983 T5498 T5497 pobj D15Mit220,between
R984 T5499 T5498 cc and,D15Mit220
R985 T5500 T5498 conj D15Mit154,D15Mit220
R986 T5563 T5562 amod pulmonary,hypoplasia
R987 T5501 T5466 punct .,defined
R988 T5564 T5562 cc and,hypoplasia
R989 T5503 T5504 prep Because,tested
R990 T5505 T5503 pcomp of,Because
R991 T5506 T5507 det the,lack
R992 T5565 T5566 det an,diaphragm
R993 T5507 T5503 pobj lack,Because
R994 T5508 T5507 prep of,lack
R995 T5509 T5510 amod informative,markers
R996 T5510 T5508 pobj markers,of
R997 T5566 T5562 conj diaphragm,hypoplasia
R998 T5567 T5566 amod abnormal,diaphragm
R999 T5511 T5507 prep within,lack
R1000 T5568 T5555 punct .,identified
R1001 T5512 T5513 det this,interval
R1002 T5570 T5571 amod Pulmonary,hypoplasia
R1003 T5513 T5511 pobj interval,within
R1004 T5514 T5504 punct ", ",tested
R1005 T5515 T5516 quantmod an,39
R1006 T5516 T5518 nummod 39,progeny
R1007 T5571 T5572 nsubj hypoplasia,was
R1008 T5517 T5516 amod additional,39
R1009 T5518 T5504 nsubjpass progeny,tested
R1010 T5573 T5572 acomp apparent,was
R1011 T5519 T5518 compound F2,progeny
R1012 T5520 T5518 prep from,progeny
R1013 T5521 T5522 det an,cross
R1014 T5574 T5572 prep in,was
R1015 T5522 T5520 pobj cross,from
R1016 T5523 T5524 nmod A,J
R1017 T5524 T5522 nmod J,cross
R1018 T5575 T5576 det all,mice
R1019 T5525 T5524 punct /,J
R1020 T5526 T5524 punct ×,J
R1021 T5576 T5574 pobj mice,in
R1022 T5527 T5528 compound C57BL,6J
R1023 T5528 T5524 appos 6J,J
R1024 T5529 T5528 punct /,6J
R1025 T5530 T5504 auxpass were,tested
R1026 T5577 T5576 compound mutant,mice
R1027 T5531 T5504 punct .,tested
R1028 T5578 T5579 dep that,survived
R1029 T5533 T5534 det The,identification
R1030 T5534 T5535 nsubj identification,established
R1031 T5579 T5576 relcl survived,mice
R1032 T5536 T5534 prep of,identification
R1033 T5537 T5538 nummod two,recombinants
R1034 T5538 T5536 pobj recombinants,of
R1035 T5539 T5535 dobj D15Mit85,established
R1036 T5580 T5579 prep to,survived
R1037 T5540 T5535 prep as,established
R1038 T5541 T5542 det the,proximal
R1039 T5542 T5540 pobj proximal,as
R1040 T5581 T5580 pobj birth,to
R1041 T5543 T5535 cc and,established
R1042 T5544 T5535 conj D15Mit5,established
R1043 T5582 T5572 punct .,was
R1044 T5545 T5544 prep as,D15Mit5
R1045 T5546 T5547 det the,distal
R1046 T5547 T5545 pobj distal,as
R1047 T5584 T5585 prep In,were
R1048 T5586 T5587 det a,comparison
R1049 T5587 T5584 pobj comparison,In
R1050 T5655 T5653 prep from,lungs
R1051 T5656 T5657 compound mutant,mice
R1052 T5588 T5587 prep between,comparison
R1053 T5657 T5655 pobj mice,from
R1054 T5658 T5654 aux were,lacking
R1055 T5659 T5660 det an,lobe
R1056 T5589 T5590 amod wild,type
R1057 T5660 T5654 dobj lobe,lacking
R1058 T5661 T5660 amod accessory,lobe
R1059 T5590 T5592 nmod type,mice
R1060 T5662 T5654 prep on,lacking
R1061 T5663 T5664 det the,side
R1062 T5664 T5662 pobj side,on
R1063 T5591 T5590 punct -,type
R1064 T5665 T5664 amod right,side
R1065 T5592 T5588 pobj mice,between
R1066 T5666 T5654 cc and,lacking
R1067 T5667 T5654 conj had,lacking
R1068 T5668 T5667 dobj underdevelopment,had
R1069 T5669 T5668 prep of,underdevelopment
R1070 T5593 T5590 cc and,type
R1071 T5670 T5671 det the,lobe
R1072 T5671 T5669 pobj lobe,of
R1073 T5672 T5671 amod anterior,lobe
R1074 T5594 T5590 conj mutant,type
R1075 T5673 T5671 amod right,lobe
R1076 T5674 T5671 amod middle,lobe
R1077 T5595 T5592 acl found,mice
R1078 T5675 T5676 punct (,Figure
R1079 T5676 T5667 parataxis Figure,had
R1080 T5677 T5676 nummod 1A,Figure
R1081 T5596 T5595 oprd dead,found
R1082 T5678 T5676 punct ),Figure
R1083 T5679 T5654 punct .,lacking
R1084 T5597 T5595 prep on,found
R1085 T5681 T5682 nsubj Diaphragms,were
R1086 T5683 T5681 prep from,Diaphragms
R1087 T5598 T5597 pobj day,on
R1088 T5684 T5685 compound mutant,mice
R1089 T5685 T5683 pobj mice,from
R1090 T5686 T5685 compound lil,mice
R1091 T5599 T5598 nummod one,day
R1092 T5600 T5598 prep of,day
R1093 T5687 T5682 acomp intact,were
R1094 T5688 T5682 punct ", ",were
R1095 T5689 T5682 cc but,were
R1096 T5601 T5600 pobj life,of
R1097 T5690 T5691 nsubj muscularization,was
R1098 T5691 T5682 conj was,were
R1099 T5692 T5691 acomp absent,was
R1100 T5693 T5691 prep in,was
R1101 T5694 T5695 det the,regions
R1102 T5695 T5693 pobj regions,in
R1103 T5602 T5585 punct ", ",were
R1104 T5696 T5695 amod dorsal,regions
R1105 T5697 T5691 punct .,was
R1106 T5603 T5604 compound body,weights
R1107 T5699 T5700 nsubj Myotubules,were
R1108 T5701 T5700 acomp present,were
R1109 T5604 T5605 nsubj weights,were
R1110 T5702 T5700 prep in,were
R1111 T5703 T5704 det a,distribution
R1112 T5704 T5702 pobj distribution,in
R1113 T5705 T5704 amod limited,distribution
R1114 T5605 T5585 ccomp were,were
R1115 T5706 T5705 cc and,limited
R1116 T5707 T5705 conj abnormal,limited
R1117 T5708 T5700 punct .,were
R1118 T5606 T5605 neg not,were
R1119 T5710 T5711 advmod More,specifically
R1120 T5607 T5605 acomp different,were
R1121 T5711 T5712 advmod specifically,radiate
R1122 T5713 T5712 punct ", ",radiate
R1123 T5608 T5585 punct ;,were
R1124 T5714 T5712 nsubj myotubules,radiate
R1125 T5715 T5712 advmod normally,radiate
R1126 T5716 T5712 prep in,radiate
R1127 T5717 T5718 det a,fashion
R1128 T5609 T5585 advmod however,were
R1129 T5718 T5716 pobj fashion,in
R1130 T5719 T5718 amod mediolateral,fashion
R1131 T5610 T5585 punct ", ",were
R1132 T5720 T5721 aux to,meet
R1133 T5721 T5712 advcl meet,radiate
R1134 T5722 T5723 det the,walls
R1135 T5611 T5612 det the,weights
R1136 T5723 T5721 dobj walls,meet
R1137 T5724 T5723 amod lateral,walls
R1138 T5725 T5723 compound body,walls
R1139 T5726 T5712 punct ", ",radiate
R1140 T5612 T5585 nsubj weights,were
R1141 T5727 T5712 prep with,radiate
R1142 T5728 T5729 det a,paucity
R1143 T5613 T5612 compound lung,weights
R1144 T5729 T5727 pobj paucity,with
R1145 T5730 T5729 amod normal,paucity
R1146 T5731 T5729 prep of,paucity
R1147 T5614 T5615 advmod significantly,lower
R1148 T5732 T5733 compound muscle,fibers
R1149 T5733 T5731 pobj fibers,of
R1150 T5734 T5729 prep in,paucity
R1151 T5735 T5736 det the,region
R1152 T5736 T5734 pobj region,in
R1153 T5737 T5736 amod central,region
R1154 T5738 T5736 amod tendonous,region
R1155 T5615 T5585 acomp lower,were
R1156 T5739 T5712 punct .,radiate
R1157 T5616 T5585 prep in,were
R1158 T5741 T5742 prep In,radiated
R1159 T5617 T5618 det the,mice
R1160 T5743 T5744 det the,diaphragm
R1161 T5744 T5741 pobj diaphragm,In
R1162 T5745 T5744 compound mutant,diaphragm
R1163 T5746 T5742 punct ", ",radiated
R1164 T5618 T5616 pobj mice,in
R1165 T5747 T5742 nsubj myotubules,radiated
R1166 T5748 T5742 prep in,radiated
R1167 T5749 T5750 det a,orientation
R1168 T5619 T5618 compound mutant,mice
R1169 T5750 T5748 pobj orientation,in
R1170 T5751 T5752 amod dorsal,ventral
R1171 T5620 T5585 punct .,were
R1172 T5752 T5750 amod ventral,orientation
R1173 T5753 T5752 punct –,ventral
R1174 T5754 T5742 punct ", ",radiated
R1175 T5622 T5623 det The,weight
R1176 T5755 T5742 cc and,radiated
R1177 T5756 T5757 compound muscle,tissue
R1178 T5757 T5758 nsubj tissue,meet
R1179 T5758 T5742 conj meet,radiated
R1180 T5623 T5627 nsubj weight,was
R1181 T5759 T5758 aux did,meet
R1182 T5624 T5623 amod average,weight
R1183 T5625 T5626 compound mutant,lung
R1184 T5626 T5623 compound lung,weight
R1185 T5760 T5758 neg not,meet
R1186 T5761 T5762 det the,surface
R1187 T5628 T5629 quantmod 9.6,2.5
R1188 T5762 T5758 dobj surface,meet
R1189 T5763 T5762 amod entire,surface
R1190 T5764 T5762 prep of,surface
R1191 T5765 T5766 det the,walls
R1192 T5629 T5631 nummod 2.5,mg
R1193 T5766 T5764 pobj walls,of
R1194 T5767 T5766 compound body,walls
R1195 T5768 T5769 punct (,Figure
R1196 T5630 T5629 punct ±,2.5
R1197 T5769 T5758 parataxis Figure,meet
R1198 T5770 T5769 nummod 1B,Figure
R1199 T5771 T5769 punct ),Figure
R1200 T5631 T5627 attr mg,was
R1201 T5772 T5758 punct .,meet
R1202 T5774 T5775 det The,number
R1203 T5632 T5633 mark while,was
R1204 T5775 T5776 nsubj number,was
R1205 T5633 T5627 advcl was,was
R1206 T5777 T5775 prep of,number
R1207 T5778 T5779 compound lil,mice
R1208 T5634 T5635 det the,weight
R1209 T5779 T5777 pobj mice,of
R1210 T5780 T5779 compound mutant,mice
R1211 T5781 T5782 dep that,survived
R1212 T5635 T5633 nsubj weight,was
R1213 T5782 T5779 relcl survived,mice
R1214 T5783 T5782 prep to,survived
R1215 T5784 T5783 pobj birth,to
R1216 T5636 T5635 amod average,weight
R1217 T5785 T5786 amod less,5
R1218 T5786 T5788 nummod 5,%
R1219 T5787 T5786 quantmod than,5
R1220 T5637 T5638 amod wild,type
R1221 T5788 T5776 attr %,was
R1222 T5789 T5788 prep of,%
R1223 T5638 T5640 compound type,lung
R1224 T5790 T5791 amod total,progeny
R1225 T5791 T5789 pobj progeny,of
R1226 T5792 T5776 punct ", ",was
R1227 T5793 T5794 advmod rather,than
R1228 T5639 T5638 punct -,type
R1229 T5794 T5776 prep than,was
R1230 T5795 T5796 det the,%
R1231 T5640 T5635 compound lung,weight
R1232 T5796 T5794 pobj %,than
R1233 T5797 T5796 nummod 25,%
R1234 T5641 T5642 quantmod 26.4,4.6
R1235 T5642 T5644 nummod 4.6,mg
R1236 T5798 T5796 acl expected,%
R1237 T5799 T5798 prep for,expected
R1238 T5643 T5642 punct ±,4.6
R1239 T5800 T5801 det a,mutation
R1240 T5801 T5799 pobj mutation,for
R1241 T5802 T5801 amod recessive,mutation
R1242 T5644 T5633 attr mg,was
R1243 T5803 T5776 punct .,was
R1244 T5645 T5646 punct (,0.001
R1245 T5805 T5806 nsubj We,evaluated
R1246 T5807 T5806 dobj litters,evaluated
R1247 T5646 T5627 parataxis 0.001,was
R1248 T5808 T5806 prep at,evaluated
R1249 T5809 T5810 amod different,points
R1250 T5810 T5808 pobj points,at
R1251 T5647 T5646 nsubj p,0.001
R1252 T5811 T5810 amod embryonic,points
R1253 T5812 T5810 compound time,points
R1254 T5813 T5814 aux to,determine
R1255 T5814 T5806 advcl determine,evaluated
R1256 T5815 T5816 mark whether,was
R1257 T5816 T5814 ccomp was,determine
R1258 T5648 T5646 punct <,0.001
R1259 T5817 T5818 det the,number
R1260 T5818 T5816 nsubj number,was
R1261 T5819 T5818 amod reduced,number
R1262 T5820 T5816 prep due,was
R1263 T5649 T5646 punct ),0.001
R1264 T5821 T5820 pcomp to,due
R1265 T5822 T5823 amod intra-uterine,demise
R1266 T5650 T5627 punct .,was
R1267 T5823 T5820 pobj demise,due
R1268 T5824 T5806 punct .,evaluated
R1269 T5826 T5827 nsubjpass Litters,collected
R1270 T5652 T5653 det All,lungs
R1271 T5828 T5827 auxpass were,collected
R1272 T5829 T5827 prep at,collected
R1273 T5830 T5829 pobj E12.5,at
R1274 T5653 T5654 nsubj lungs,lacking
R1275 T5831 T5830 punct ", ",E12.5
R1276 T5832 T5830 nummod 13.5,E12.5
R1277 T5833 T5830 punct ", ",E12.5
R1278 T5867 T5868 det a,rate
R1279 T5834 T5830 nummod 15.5,E12.5
R1280 T5835 T5830 punct ", ",E12.5
R1281 T5836 T5830 nummod 17.5,E12.5
R1282 T5837 T5830 punct ", ",E12.5
R1283 T5838 T5830 cc and,E12.5
R1284 T5839 T5830 conj 18.5,E12.5
R1285 T5840 T5827 punct ", ",collected
R1286 T5841 T5827 cc and,collected
R1287 T5842 T5843 nsubjpass embryos,genotyped
R1288 T5868 T5866 dobj rate,had
R1289 T5843 T5827 conj genotyped,collected
R1290 T5844 T5843 auxpass were,genotyped
R1291 T5845 T5843 cc and,genotyped
R1292 T5869 T5870 advmod progressively,higher
R1293 T5846 T5843 conj evaluated,genotyped
R1294 T5847 T5846 prep for,evaluated
R1295 T5848 T5847 pobj evidence,for
R1296 T5870 T5868 amod higher,rate
R1297 T5849 T5848 prep of,evidence
R1298 T5850 T5851 amod intra-uterine,demise
R1299 T5871 T5868 prep of,rate
R1300 T5851 T5849 pobj demise,of
R1301 T5852 T5848 punct ", ",evidence
R1302 T5853 T5848 prep including,evidence
R1303 T5872 T5871 pobj demise,of
R1304 T5854 T5855 compound growth,retardation
R1305 T5855 T5853 pobj retardation,including
R1306 T5856 T5855 punct ", ",retardation
R1307 T5857 T5855 conj pallor,retardation
R1308 T5858 T5857 punct ", ",pallor
R1309 T5873 T5866 prep between,had
R1310 T5859 T5857 cc and,pallor
R1311 T5860 T5861 compound tissue,friability
R1312 T5874 T5873 pobj E13.5,between
R1313 T5861 T5857 conj friability,pallor
R1314 T5875 T5874 cc and,E13.5
R1315 T5862 T5843 punct .,genotyped
R1316 T5876 T5874 conj E15.5,E13.5
R1317 T5864 T5865 compound lil,embryos
R1318 T5865 T5866 nsubj embryos,had
R1319 T5877 T5866 punct .,had
R1320 T5879 T5880 prep At,were
R1321 T5881 T5879 pobj E12.5,At
R1322 T5972 T5973 advmod only,embryo
R1323 T5973 T5970 nsubj embryo,was
R1324 T5882 T5880 punct ", ",were
R1325 T5974 T5973 nummod one,embryo
R1326 T5975 T5970 acomp viable,was
R1327 T5976 T5953 punct .,were
R1328 T5883 T5884 quantmod 20,87
R1329 T5978 T5979 amod Diaphragmatic,muscularization
R1330 T5979 T5980 nsubj muscularization,was
R1331 T5884 T5880 nsubj 87,were
R1332 T5981 T5980 acomp abnormal,was
R1333 T5982 T5980 prep in,was
R1334 T5885 T5884 quantmod out,87
R1335 T5983 T5984 det all,mice
R1336 T5886 T5884 quantmod of,87
R1337 T5984 T5982 pobj mice,in
R1338 T5887 T5888 punct (,%
R1339 T5985 T5984 compound mutant,mice
R1340 T5986 T5984 acl examined,mice
R1341 T5987 T5988 punct (,25
R1342 T5988 T5980 parataxis 25,was
R1343 T5888 T5884 parataxis %,87
R1344 T5989 T5988 nsubj n,25
R1345 T5990 T5988 punct >,25
R1346 T5991 T5988 punct ),25
R1347 T5889 T5888 nummod 23,%
R1348 T5992 T5980 punct .,was
R1349 T5890 T5888 punct ),%
R1350 T5994 T5995 amod Pulmonary,hypoplasia
R1351 T5995 T5996 nsubjpass hypoplasia,observed
R1352 T5891 T5880 acomp homozygous,were
R1353 T5997 T5996 auxpass was,observed
R1354 T5998 T5996 prep in,observed
R1355 T5999 T6000 nummod 100,%
R1356 T5892 T5891 prep for,homozygous
R1357 T6000 T5998 pobj %,in
R1358 T6001 T6000 prep of,%
R1359 T6002 T6001 pobj mutants,of
R1360 T6003 T6002 acl evaluated,mutants
R1361 T6004 T6003 prep for,evaluated
R1362 T6005 T6006 det that,phenotype
R1363 T5893 T5894 det the,mutation
R1364 T6006 T6004 pobj phenotype,for
R1365 T6007 T6003 prep between,evaluated
R1366 T6008 T6007 pobj E11.5,between
R1367 T5894 T5892 pobj mutation,for
R1368 T6009 T6008 cc and,E11.5
R1369 T6010 T6008 conj birth,E11.5
R1370 T6011 T6012 punct (,50
R1371 T5895 T5880 punct ", ",were
R1372 T6012 T5996 parataxis 50,observed
R1373 T6013 T6012 nsubj n,50
R1374 T6014 T6012 punct >,50
R1375 T6015 T6012 punct ),50
R1376 T5896 T5880 cc and,were
R1377 T6016 T5996 punct .,observed
R1378 T5897 T5898 nsubj all,appeared
R1379 T6018 T6019 nsubj Examination,showed
R1380 T6020 T6018 prep of,Examination
R1381 T5898 T5880 conj appeared,were
R1382 T5899 T5897 prep of,all
R1383 T6021 T6022 amod cardiac,morphology
R1384 T5900 T5899 pobj these,of
R1385 T6022 T6020 pobj morphology,of
R1386 T6023 T6024 mark that,had
R1387 T6024 T6019 ccomp had,showed
R1388 T5901 T5898 oprd viable,appeared
R1389 T6025 T6024 nsubj hearts,had
R1390 T6026 T6025 prep from,hearts
R1391 T5902 T5880 punct .,were
R1392 T6027 T6028 compound E15.5,mice
R1393 T5904 T5905 prep At,were
R1394 T6028 T6026 pobj mice,from
R1395 T6029 T6030 compound lil,mutant
R1396 T6030 T6028 compound mutant,mice
R1397 T6031 T6032 det a,variety
R1398 T6032 T6024 dobj variety,had
R1399 T5906 T5904 pobj E13.5,At
R1400 T6033 T6032 prep of,variety
R1401 T6034 T6035 amod developmental,defects
R1402 T6035 T6033 pobj defects,of
R1403 T6036 T6032 punct ", ",variety
R1404 T5907 T5905 punct ", ",were
R1405 T6037 T6032 prep including,variety
R1406 T6038 T6039 amod enlarged,cushions
R1407 T5908 T5909 quantmod 13,49
R1408 T5909 T5905 nsubj 49,were
R1409 T6039 T6037 pobj cushions,including
R1410 T6040 T6038 cc and,enlarged
R1411 T6041 T6042 advmod abnormally,developed
R1412 T6042 T6038 conj developed,enlarged
R1413 T6043 T6039 amod endocardial,cushions
R1414 T6044 T6039 punct ", ",cushions
R1415 T5910 T5909 quantmod of,49
R1416 T6045 T6046 det a,ventricle
R1417 T6046 T6039 conj ventricle,cushions
R1418 T6047 T6048 amod double,outlet
R1419 T5911 T5912 punct (,%
R1420 T6048 T6046 nmod outlet,ventricle
R1421 T6049 T6048 punct -,outlet
R1422 T6050 T6046 amod right,ventricle
R1423 T5912 T5909 parataxis %,49
R1424 T6051 T6046 punct ", ",ventricle
R1425 T6052 T6046 cc and,ventricle
R1426 T6053 T6054 det a,canal
R1427 T5913 T5912 nummod 27,%
R1428 T6054 T6046 conj canal,ventricle
R1429 T6055 T6054 amod complete,canal
R1430 T6056 T6054 amod atrioventricular,canal
R1431 T5914 T5912 punct ),%
R1432 T6057 T6019 punct .,showed
R1433 T5915 T5905 acomp mutant,were
R1434 T6059 T6060 det The,myocardium
R1435 T6060 T6061 nsubj myocardium,was
R1436 T5916 T5905 cc and,were
R1437 T6062 T6061 advmod also,was
R1438 T6063 T6064 advmod poorly,developed
R1439 T5917 T5918 nsubj two,died
R1440 T6064 T6061 acomp developed,was
R1441 T6065 T6061 punct ", ",was
R1442 T6066 T6061 prep with,was
R1443 T6067 T6066 pobj thinning,with
R1444 T5918 T5905 conj died,were
R1445 T6068 T6067 prep of,thinning
R1446 T6069 T6070 det the,layer
R1447 T5919 T5918 aux had,died
R1448 T6070 T6068 pobj layer,of
R1449 T6071 T6070 amod outer,layer
R1450 T6072 T6070 amod compact,layer
R1451 T5920 T5905 punct .,were
R1452 T6073 T6067 cc and,thinning
R1453 T6074 T6075 amod decreased,vascularity
R1454 T5922 T5923 prep At,were
R1455 T6075 T6067 conj vascularity,thinning
R1456 T6076 T6061 punct .,was
R1457 T5924 T5922 pobj E15.5,At
R1458 T5925 T5923 punct ", ",were
R1459 T6078 T6079 det The,cohort
R1460 T5926 T5927 quantmod 22,91
R1461 T6079 T6080 nsubj cohort,had
R1462 T6081 T6079 prep of,cohort
R1463 T6082 T6083 compound mutant,mice
R1464 T6083 T6081 pobj mice,of
R1465 T6084 T6085 dep that,survived
R1466 T6085 T6083 relcl survived,mice
R1467 T5927 T5923 nsubj 91,were
R1468 T6086 T6085 prep to,survived
R1469 T6087 T6086 pobj birth,to
R1470 T6088 T6080 advmod also,had
R1471 T5928 T5927 quantmod out,91
R1472 T6089 T6090 amod cardiac,malformations
R1473 T6090 T6080 dobj malformations,had
R1474 T6091 T6090 prep including,malformations
R1475 T5929 T5927 quantmod of,91
R1476 T6092 T6093 amod atrioventricular,canal
R1477 T6093 T6095 nmod canal,type
R1478 T6094 T6093 punct -,canal
R1479 T5930 T5931 punct (,%
R1480 T6095 T6097 nmod type,defects
R1481 T6096 T6095 punct -,type
R1482 T5931 T5927 parataxis %,91
R1483 T6097 T6091 pobj defects,including
R1484 T6098 T6097 amod ventricular,defects
R1485 T6099 T6097 amod septal,defects
R1486 T5932 T5931 nummod 24,%
R1487 T6100 T6097 punct ", ",defects
R1488 T6101 T6102 nmod ostium,defects
R1489 T6102 T6097 conj defects,defects
R1490 T5933 T5931 punct ),%
R1491 T6103 T6102 nmod primum,defects
R1492 T6104 T6102 amod atrial,defects
R1493 T5934 T5923 acomp mutant,were
R1494 T6105 T6102 amod septal,defects
R1495 T6106 T6102 punct ", ",defects
R1496 T6107 T6102 cc and,defects
R1497 T5935 T5923 cc and,were
R1498 T6108 T6109 amod enlarged,atria
R1499 T6109 T6102 conj atria,defects
R1500 T6110 T6111 punct (,shown
R1501 T5936 T5937 det the,majority
R1502 T6111 T6080 parataxis shown,had
R1503 T6112 T6111 nsubj data,shown
R1504 T5937 T5938 nsubj majority,died
R1505 T6113 T6111 neg not,shown
R1506 T6114 T6111 punct ),shown
R1507 T6115 T6080 punct .,had
R1508 T5938 T5923 conj died,were
R1509 T6117 T6118 det All,mutants
R1510 T6118 T6119 nsubj mutants,had
R1511 T5939 T5937 prep of,majority
R1512 T6120 T6121 advmod specifically,evaluated
R1513 T6121 T6118 acl evaluated,mutants
R1514 T6122 T6121 prep for,evaluated
R1515 T6123 T6124 det a,phenotype
R1516 T6124 T6122 pobj phenotype,for
R1517 T5940 T5941 compound mutant,embryos
R1518 T6125 T6124 amod cardiac,phenotype
R1519 T5941 T5939 pobj embryos,of
R1520 T6126 T6127 punct (,10
R1521 T6127 T6118 parataxis 10,mutants
R1522 T6128 T6127 nsubj n,10
R1523 T5942 T5943 punct (,22
R1524 T6129 T6127 punct =,10
R1525 T6130 T6127 punct ),10
R1526 T5943 T5937 parataxis 22,majority
R1527 T6131 T6132 amod abnormal,development
R1528 T6132 T6119 dobj development,had
R1529 T6133 T6132 amod cardiac,development
R1530 T6134 T6119 punct .,had
R1531 T5944 T5943 quantmod 17,22
R1532 T6136 T6137 nsubj Examination,revealed
R1533 T5945 T5943 quantmod out,22
R1534 T6138 T6136 prep of,Examination
R1535 T5946 T5943 quantmod of,22
R1536 T6139 T6140 det the,region
R1537 T6140 T6138 pobj region,of
R1538 T6141 T6142 nummod 3,Mb
R1539 T6142 T6140 compound Mb,region
R1540 T5947 T5943 quantmod the,22
R1541 T6143 T6142 punct -,Mb
R1542 T6144 T6140 prep between,region
R1543 T5948 T5943 punct ),22
R1544 T6145 T6144 pobj D15Mit85,between
R1545 T6146 T6145 cc and,D15Mit85
R1546 T6147 T6145 conj D15Mit5,D15Mit85
R1547 T5949 T5938 aux had,died
R1548 T6148 T6140 prep in,region
R1549 T6149 T6150 compound DNA,sequence
R1550 T6150 T6151 compound sequence,databases
R1551 T5950 T5938 punct .,died
R1552 T6151 T6148 pobj databases,in
R1553 T6152 T6153 nummod three,genes
R1554 T6153 T6137 dobj genes,revealed
R1555 T5952 T5953 prep By,were
R1556 T6154 T6153 amod predicted,genes
R1557 T6155 T6153 cc and,genes
R1558 T6156 T6157 nummod four,genes
R1559 T6157 T6153 conj genes,genes
R1560 T6158 T6157 amod known,genes
R1561 T5954 T5952 pobj E18.5,By
R1562 T6159 T6157 punct ", ",genes
R1563 T6160 T6157 prep including,genes
R1564 T6161 T6160 pobj Fog2,including
R1565 T6162 T6137 punct .,revealed
R1566 T6164 T6165 amod Targeted,mutations
R1567 T5955 T5953 punct ", ",were
R1568 T6165 T6166 nsubj mutations,have
R1569 T6167 T6165 prep of,mutations
R1570 T5956 T5957 quantmod nine,29
R1571 T6168 T6167 pobj Fog2,of
R1572 T6169 T6170 amod cardiac,defects
R1573 T6170 T6166 dobj defects,have
R1574 T6171 T6172 advmod strikingly,similar
R1575 T5957 T5959 nummod 29,embryos
R1576 T6172 T6170 amod similar,defects
R1577 T6173 T6172 prep to,similar
R1578 T6174 T6173 pobj those,to
R1579 T5958 T5957 quantmod of,29
R1580 T6175 T6176 nsubj we,identified
R1581 T6176 T6174 advcl identified,those
R1582 T5959 T5953 nsubj embryos,were
R1583 T6177 T6176 prep in,identified
R1584 T5960 T5961 punct (,%
R1585 T6178 T6179 compound lil,mice
R1586 T6179 T6177 pobj mice,in
R1587 T6180 T6179 compound mutant,mice
R1588 T6181 T6170 punct ", ",defects
R1589 T5961 T5959 parataxis %,embryos
R1590 T6182 T6170 prep including,defects
R1591 T6183 T6184 amod atrioventricular,defects
R1592 T5962 T5961 nummod 31,%
R1593 T5963 T5961 punct ),%
R1594 T5964 T5953 acomp homozygous,were
R1595 T6184 T6182 pobj defects,including
R1596 T5965 T5964 prep for,homozygous
R1597 T6185 T6184 compound canal,defects
R1598 T6186 T6184 punct ", ",defects
R1599 T6187 T6188 amod thinned,myocardium
R1600 T5966 T5967 det the,mutation
R1601 T6188 T6184 conj myocardium,defects
R1602 T6189 T6188 punct ", ",myocardium
R1603 T6190 T6188 cc and,myocardium
R1604 T5967 T5965 pobj mutation,for
R1605 T6191 T6192 amod absent,vasculature
R1606 T6192 T6188 conj vasculature,myocardium
R1607 T6193 T6192 amod coronary,vasculature
R1608 T5968 T5953 punct ", ",were
R1609 T5969 T5970 prep of,was
R1610 T6194 T6195 punct [,16
R1611 T5970 T5953 ccomp was,were
R1612 T6195 T6166 parataxis 16,have
R1613 T5971 T5969 pobj which,of
R1614 T6196 T6195 punct ],16
R1615 T6197 T6166 punct .,have
R1616 T6290 T6291 det a,codon
R1617 T6199 T6200 compound RT,PCR
R1618 T6200 T6202 compound PCR,amplification
R1619 T6201 T6200 punct -,PCR
R1620 T6202 T6203 nsubj amplification,revealed
R1621 T6204 T6202 prep of,amplification
R1622 T6205 T6206 det the,portion
R1623 T6206 T6204 pobj portion,of
R1624 T6207 T6206 amod proximal,portion
R1625 T6208 T6206 prep of,portion
R1626 T6209 T6208 pobj Fog2,of
R1627 T6210 T6211 amod longer,transcripts
R1628 T6211 T6203 dobj transcripts,revealed
R1629 T6291 T6289 dobj codon,introduces
R1630 T6212 T6211 prep in,transcripts
R1631 T6213 T6214 det the,mutant
R1632 T6292 T6291 compound stop,codon
R1633 T6214 T6212 pobj mutant,in
R1634 T6215 T6214 compound lil,mutant
R1635 T6216 T6211 prep than,transcripts
R1636 T6293 T6294 dep that,generates
R1637 T6217 T6216 prep in,than
R1638 T6218 T6219 det the,type
R1639 T6219 T6217 pobj type,in
R1640 T6294 T6291 relcl generates,codon
R1641 T6220 T6219 amod wild,type
R1642 T6221 T6219 punct -,type
R1643 T6295 T6296 det a,product
R1644 T6222 T6211 appos embryos,transcripts
R1645 T6223 T6224 punct (,Figure
R1646 T6224 T6203 parataxis Figure,revealed
R1647 T6296 T6294 dobj product,generates
R1648 T6225 T6224 nummod 2A,Figure
R1649 T6226 T6224 punct ),Figure
R1650 T6227 T6203 punct .,revealed
R1651 T6229 T6230 nsubj Sequencing,revealed
R1652 T6297 T6298 advmod severely,truncated
R1653 T6231 T6229 prep of,Sequencing
R1654 T6232 T6233 det the,transcript
R1655 T6298 T6296 amod truncated,product
R1656 T6233 T6231 pobj transcript,of
R1657 T6234 T6233 compound mutant,transcript
R1658 T6235 T6236 det a,mutation
R1659 T6299 T6296 compound protein,product
R1660 T6236 T6230 dobj mutation,revealed
R1661 T6237 T6236 compound point,mutation
R1662 T6238 T6236 punct (,mutation
R1663 T6300 T6301 punct (,Figure
R1664 T6239 T6236 prep from,mutation
R1665 T6240 T6239 pobj thymine,from
R1666 T6301 T6289 parataxis Figure,introduces
R1667 T6241 T6239 prep to,from
R1668 T6242 T6241 pobj cytosine,to
R1669 T6243 T6236 punct ),mutation
R1670 T6244 T6245 nummod 2,bp
R1671 T6245 T6246 npadvmod bp,after
R1672 T6246 T6230 prep after,revealed
R1673 T6302 T6301 nummod 2B,Figure
R1674 T6247 T6246 pobj position,after
R1675 T6248 T6247 nummod 301,position
R1676 T6303 T6301 punct ),Figure
R1677 T6249 T6247 punct ", ",position
R1678 T6250 T6251 dep which,is
R1679 T6251 T6247 relcl is,position
R1680 T6304 T6268 punct .,causes
R1681 T6252 T6251 prep in,is
R1682 T6253 T6254 det the,site
R1683 T6254 T6252 pobj site,in
R1684 T6306 T6307 amod Heterozygous,mice
R1685 T6255 T6254 compound splice,site
R1686 T6256 T6254 compound donor,site
R1687 T6257 T6254 prep at,site
R1688 T6258 T6259 det the,end
R1689 T6259 T6257 pobj end,at
R1690 T6307 T6310 nsubjpass mice,crossed
R1691 T6260 T6259 prep of,end
R1692 T6261 T6262 det the,exon
R1693 T6262 T6260 pobj exon,of
R1694 T6308 T6309 compound lil,mutant
R1695 T6263 T6262 amod third,exon
R1696 T6264 T6230 punct .,revealed
R1697 T6309 T6307 compound mutant,mice
R1698 T6266 T6267 det This,mutation
R1699 T6267 T6268 nsubj mutation,causes
R1700 T6311 T6310 auxpass were,crossed
R1701 T6269 T6270 det a,defect
R1702 T6270 T6268 dobj defect,causes
R1703 T6271 T6270 compound splicing,defect
R1704 T6272 T6273 dep that,results
R1705 T6312 T6310 prep with,crossed
R1706 T6273 T6270 relcl results,defect
R1707 T6274 T6273 prep in,results
R1708 T6313 T6314 det a,mutant
R1709 T6275 T6276 det the,insertion
R1710 T6276 T6274 pobj insertion,in
R1711 T6277 T6276 prep of,insertion
R1712 T6314 T6312 pobj mutant,with
R1713 T6278 T6279 nummod 85,bp
R1714 T6279 T6277 pobj bp,of
R1715 T6315 T6314 nmod Fog2,mutant
R1716 T6280 T6279 prep of,bp
R1717 T6281 T6282 amod intronic,sequence
R1718 T6316 T6315 punct +,Fog2
R1719 T6282 T6280 pobj sequence,of
R1720 T6283 T6276 prep into,insertion
R1721 T6284 T6285 det the,transcript
R1722 T6285 T6283 pobj transcript,into
R1723 T6286 T6285 compound mutant,transcript
R1724 T6317 T6315 punct /,Fog2
R1725 T6287 T6268 punct ", ",causes
R1726 T6288 T6268 cc and,causes
R1727 T6289 T6268 conj introduces,causes
R1728 T6318 T6315 punct −,Fog2
R1729 T6319 T6320 punct (,allele
R1730 T6320 T6314 parataxis allele,mutant
R1731 T6321 T6320 amod null,allele
R1732 T6322 T6320 punct ),allele
R1733 T6323 T6314 acl generated,mutant
R1734 T6324 T6323 prep by,generated
R1735 T6325 T6326 compound gene,targeting
R1736 T6326 T6324 pobj targeting,by
R1737 T6327 T6328 punct [,16
R1738 T6328 T6310 parataxis 16,crossed
R1739 T6329 T6328 punct ],16
R1740 T6330 T6310 punct .,crossed
R1741 T6332 T6333 advmod Doubly,heterozygous
R1742 T6333 T6334 amod heterozygous,mice
R1743 T6334 T6335 nsubj mice,had
R1744 T6335 T6336 ccomp had,proves
R1745 T6337 T6338 det an,phenotype
R1746 T6338 T6335 dobj phenotype,had
R1747 T6339 T6338 amod embryonic,phenotype
R1748 T6340 T6338 amod lethal,phenotype
R1749 T6341 T6336 punct ;,proves
R1750 T6342 T6343 det this,failure
R1751 T6343 T6336 nsubj failure,proves
R1752 T6344 T6345 aux to,complement
R1753 T6345 T6343 acl complement,failure
R1754 T6346 T6347 mark that,is
R1755 T6347 T6336 ccomp is,proves
R1756 T6348 T6347 nsubj lil,is
R1757 T6349 T6350 det a,mutation
R1758 T6350 T6347 attr mutation,is
R1759 T6351 T6350 prep in,mutation
R1760 T6352 T6351 pobj Fog2,in
R1761 T6353 T6336 punct .,proves
R1762 T6355 T6356 det The,phenotype
R1763 T6356 T6358 nsubj phenotype,is
R1764 T6357 T6356 amod variable,phenotype
R1765 T6359 T6356 prep of,phenotype
R1766 T6360 T6361 compound lil,mice
R1767 T6361 T6359 pobj mice,of
R1768 T6362 T6356 punct (,phenotype
R1769 T6363 T6356 amod relative,phenotype
R1770 T6364 T6363 prep to,relative
R1771 T6365 T6364 pobj that,to
R1772 T6366 T6365 acl found,that
R1773 T6367 T6366 prep for,found
R1774 T6368 T6369 det the,mutant
R1775 T6369 T6367 pobj mutant,for
R1776 T6370 T6369 nmod Fog2,mutant
R1777 T6371 T6370 amod null,Fog2
R1778 T6372 T6358 punct ),is
R1779 T6373 T6358 advmod likely,is
R1780 T6374 T6358 prep due,is
R1781 T6375 T6374 pcomp to,due
R1782 T6376 T6377 det the,generation
R1783 T6377 T6374 pobj generation,due
R1784 T6378 T6377 prep of,generation
R1785 T6379 T6380 det a,level
R1786 T6380 T6378 pobj level,of
R1787 T6381 T6380 amod low,level
R1788 T6382 T6380 prep of,level
R1789 T6383 T6384 amod normal,transcript
R1790 T6384 T6382 pobj transcript,of
R1791 T6385 T6377 prep despite,generation
R1792 T6386 T6387 det the,presence
R1793 T6387 T6385 pobj presence,despite
R1794 T6388 T6387 prep of,presence
R1795 T6389 T6390 det the,mutation
R1796 T6390 T6388 pobj mutation,of
R1797 T6391 T6392 compound splice,site
R1798 T6392 T6390 compound site,mutation
R1799 T6393 T6358 punct .,is
R1805 T8121 T8122 nmod Lung,Development
R1806 T8123 T8121 cc and,Lung
R1807 T8124 T8121 conj Diaphragm,Lung
R1808 T8125 T8122 prep in,Development
R1809 T8126 T8127 det the,Mouse
R1810 T8127 T8125 pobj Mouse,in
R1811 T8128 T8129 compound Fog2,Mutant
R1812 T8129 T8127 compound Mutant,Mouse
R1813 T8131 T8132 nsubjpass Experiments,conducted
R1814 T8133 T8132 auxpass were,conducted
R1815 T8134 T8135 aux to,evaluate
R1816 T8135 T8132 advcl evaluate,conducted
R1817 T8136 T8137 det the,role
R1818 T8137 T8135 dobj role,evaluate
R1819 T8138 T8137 prep of,role
R1820 T8139 T8138 pobj Fog2,of
R1821 T8140 T8137 prep in,role
R1822 T8141 T8142 amod pulmonary,development
R1823 T8142 T8140 pobj development,in
R1824 T8143 T8141 cc and,pulmonary
R1825 T8144 T8141 conj diaphragmatic,pulmonary
R1826 T8145 T8132 punct .,conducted
R1827 T8147 T8148 det The,phenotype
R1828 T8148 T8150 nsubjpass phenotype,characterized
R1829 T8149 T8148 amod pulmonary,phenotype
R1830 T8151 T8150 auxpass is,characterized
R1831 T8152 T8150 agent by,characterized
R1832 T8153 T8154 amod diffuse,hypoplasia
R1833 T8154 T8152 pobj hypoplasia,by
R1834 T8155 T8154 cc and,hypoplasia
R1835 T8156 T8157 amod specific,loss
R1836 T8157 T8154 conj loss,hypoplasia
R1837 T8158 T8157 prep of,loss
R1838 T8159 T8160 det the,lobe
R1839 T8160 T8158 pobj lobe,of
R1840 T8161 T8160 amod accessory,lobe
R1841 T8162 T8160 cc and,lobe
R1842 T8163 T8164 det a,portion
R1843 T8164 T8160 conj portion,lobe
R1844 T8165 T8164 prep of,portion
R1845 T8166 T8167 det the,lobe
R1846 T8167 T8165 pobj lobe,of
R1847 T8168 T8167 amod right,lobe
R1848 T8169 T8167 amod middle,lobe
R1849 T8170 T8150 punct .,characterized
R1850 T8172 T8173 nsubj It,is
R1851 T8174 T8175 advmod well,established
R1852 T8175 T8173 acomp established,is
R1853 T8176 T8177 mark that,result
R1854 T8177 T8173 ccomp result,is
R1855 T8178 T8177 nsubj abnormalities,result
R1856 T8179 T8178 prep in,abnormalities
R1857 T8180 T8181 preconj either,development
R1858 T8181 T8179 pobj development,in
R1859 T8182 T8181 amod diaphragmatic,development
R1860 T8183 T8181 cc or,development
R1861 T8184 T8185 amod fetal,breathing
R1862 T8185 T8181 conj breathing,development
R1863 T8186 T8177 aux can,result
R1864 T8187 T8177 prep in,result
R1865 T8188 T8189 det a,hypoplasia
R1866 T8189 T8187 pobj hypoplasia,in
R1867 T8190 T8189 amod secondary,hypoplasia
R1868 T8191 T8189 amod pulmonary,hypoplasia
R1869 T8192 T8177 punct ", ",result
R1870 T8193 T8194 mark although,documented
R1871 T8194 T8177 advcl documented,result
R1872 T8195 T8194 nsubjpass loss,documented
R1873 T8196 T8195 prep of,loss
R1874 T8197 T8198 amod normal,structure
R1875 T8198 T8196 pobj structure,of
R1876 T8199 T8194 aux has,documented
R1877 T8200 T8194 neg never,documented
R1878 T8201 T8194 auxpass been,documented
R1879 T8202 T8194 prep in,documented
R1880 T8203 T8204 det this,context
R1881 T8204 T8202 pobj context,in
R1882 T8205 T8206 punct [,18
R1883 T8206 T8173 parataxis 18,is
R1884 T8207 T8206 nummod 17,18
R1885 T8208 T8206 punct ",",18
R1886 T8209 T8206 punct ],18
R1887 T8210 T8173 punct .,is
R1888 T8212 T8213 nsubjpass Fog2,expressed
R1889 T8214 T8213 auxpass is,expressed
R1890 T8215 T8213 advmod diffusely,expressed
R1891 T8216 T8213 prep in,expressed
R1892 T8217 T8218 det the,mesenchyme
R1893 T8218 T8216 pobj mesenchyme,in
R1894 T8219 T8218 amod pulmonary,mesenchyme
R1895 T8220 T8213 prep during,expressed
R1896 T8221 T8222 det the,period
R1897 T8222 T8220 pobj period,during
R1898 T8223 T8222 prep of,period
R1899 T8224 T8225 compound branching,morphogenesis
R1900 T8225 T8223 pobj morphogenesis,of
R1901 T8226 T8213 punct ", ",expressed
R1902 T8227 T8228 mark while,restricted
R1903 T8228 T8213 advcl restricted,expressed
R1904 T8229 T8230 amod later,expression
R1905 T8230 T8228 nsubjpass expression,restricted
R1906 T8231 T8228 auxpass is,restricted
R1907 T8232 T8228 prep to,restricted
R1908 T8233 T8234 det the,muscles
R1909 T8234 T8232 pobj muscles,to
R1910 T8235 T8234 amod smooth,muscles
R1911 T8236 T8234 prep of,muscles
R1912 T8237 T8236 pobj airways,of
R1913 T8238 T8237 cc and,airways
R1914 T8239 T8240 amod pulmonary,vessels
R1915 T8240 T8237 conj vessels,airways
R1916 T8241 T8242 punct (,Figure
R1917 T8242 T8213 parataxis Figure,expressed
R1918 T8243 T8242 nummod 3,Figure
R1919 T8244 T8242 punct ),Figure
R1920 T8245 T8213 punct .,expressed
R1921 T8247 T8248 nsubj This,suggests
R1922 T8249 T8247 punct ", ",This
R1923 T8250 T8247 cc and,This
R1924 T8251 T8252 det the,observation
R1925 T8252 T8247 conj observation,This
R1926 T8253 T8254 mark that,appeared
R1927 T8254 T8252 acl appeared,observation
R1928 T8255 T8254 nsubj lungs,appeared
R1929 T8256 T8254 oprd small,appeared
R1930 T8257 T8254 prep on,appeared
R1931 T8258 T8259 amod transverse,sections
R1932 T8259 T8257 pobj sections,on
R1933 T8260 T8259 acl evaluated,sections
R1934 T8261 T8262 amod prior,to
R1935 T8262 T8260 prep to,evaluated
R1936 T8263 T8264 amod diaphragmatic,muscularization
R1937 T8264 T8262 pobj muscularization,to
R1938 T8265 T8264 cc or,muscularization
R1939 T8266 T8264 conj function,muscularization
R1940 T8267 T8248 punct ", ",suggests
R1941 T8268 T8269 mark that,occurs
R1942 T8269 T8248 ccomp occurs,suggests
R1943 T8270 T8271 det the,hypoplasia
R1944 T8271 T8269 nsubj hypoplasia,occurs
R1945 T8272 T8271 amod pulmonary,hypoplasia
R1946 T8273 T8269 advmod independently,occurs
R1947 T8274 T8273 prep of,independently
R1948 T8275 T8276 det the,defect
R1949 T8276 T8274 pobj defect,of
R1950 T8277 T8276 amod diaphragmatic,defect
R1951 T8278 T8248 punct .,suggests
R1952 T8280 T8281 aux To,test
R1953 T8281 T8282 advcl test,dissected
R1954 T8283 T8284 det this,hypothesis
R1955 T8284 T8281 dobj hypothesis,test
R1956 T8285 T8282 punct ", ",dissected
R1957 T8286 T8282 nsubjpass lungs,dissected
R1958 T8287 T8282 auxpass were,dissected
R1959 T8288 T8282 prep from,dissected
R1960 T8289 T8290 nmod Fog2,mice
R1961 T8290 T8288 pobj mice,from
R1962 T8291 T8289 punct −,Fog2
R1963 T8292 T8289 punct /,Fog2
R1964 T8293 T8289 punct −,Fog2
R1965 T8294 T8290 cc and,mice
R1966 T8295 T8296 compound littermate,controls
R1967 T8296 T8290 conj controls,mice
R1968 T8297 T8282 prep before,dissected
R1969 T8298 T8299 det the,onset
R1970 T8299 T8297 pobj onset,before
R1971 T8300 T8299 prep of,onset
R1972 T8301 T8302 amod fetal,motion
R1973 T8302 T8300 pobj motion,of
R1974 T8303 T8302 amod diaphragmatic,motion
R1975 T8304 T8282 punct .,dissected
R1976 T8306 T8307 nmod Fog2,mice
R1977 T8307 T8311 nsubjpass mice,used
R1978 T8308 T8306 punct −,Fog2
R1979 T8309 T8306 punct /,Fog2
R1980 T8310 T8306 punct −,Fog2
R1981 T8312 T8311 auxpass were,used
R1982 T8313 T8311 prep for,used
R1983 T8314 T8315 det this,experiment
R1984 T8315 T8313 pobj experiment,for
R1985 T8316 T8311 punct ", ",used
R1986 T8317 T8318 mark as,wanted
R1987 T8318 T8311 advcl wanted,used
R1988 T8319 T8318 nsubj we,wanted
R1989 T8320 T8321 aux to,avoid
R1990 T8321 T8318 xcomp avoid,wanted
R1991 T8322 T8323 amod potential,variance
R1992 T8323 T8321 dobj variance,avoid
R1993 T8324 T8323 amod phenotypic,variance
R1994 T8325 T8323 prep from,variance
R1995 T8326 T8327 det the,mutation
R1996 T8327 T8325 pobj mutation,from
R1997 T8328 T8327 nmod lil,mutation
R1998 T8329 T8327 amod hypomorphic,mutation
R1999 T8330 T8311 punct .,used
R2000 T8332 T8333 nsubj Lungs,were
R2001 T8334 T8332 acl dissected,Lungs
R2002 T8335 T8334 prep at,dissected
R2003 T8336 T8335 pobj E12,at
R2004 T8337 T8332 prep from,Lungs
R2005 T8338 T8339 nmod Fog2,embryos
R2006 T8339 T8337 pobj embryos,from
R2007 T8340 T8338 punct −,Fog2
R2008 T8341 T8338 punct /,Fog2
R2009 T8342 T8338 punct −,Fog2
R2010 T8343 T8333 acomp smaller,were
R2011 T8344 T8343 prep in,smaller
R2012 T8345 T8344 pobj size,in
R2013 T8346 T8333 cc and,were
R2014 T8347 T8333 conj lacked,were
R2015 T8348 T8349 det the,development
R2016 T8349 T8347 dobj development,lacked
R2017 T8350 T8349 prep of,development
R2018 T8351 T8352 det an,lobe
R2019 T8352 T8350 pobj lobe,of
R2020 T8353 T8352 amod accessory,lobe
R2021 T8354 T8333 punct .,were
R2022 T8356 T8357 prep In,was
R2023 T8358 T8359 nummod 11,explants
R2024 T8359 T8356 pobj explants,In
R2025 T8360 T8359 amod viable,explants
R2026 T8361 T8359 nmod Fog2,explants
R2027 T8362 T8361 punct −,Fog2
R2028 T8363 T8361 punct /,Fog2
R2029 T8364 T8361 punct −,Fog2
R2030 T8365 T8366 compound lung,culture
R2031 T8366 T8359 compound culture,explants
R2032 T8367 T8357 punct ", ",was
R2033 T8368 T8357 expl there,was
R2034 T8369 T8357 neg never,was
R2035 T8370 T8357 attr development,was
R2036 T8371 T8370 prep of,development
R2037 T8372 T8373 det an,lobe
R2038 T8373 T8371 pobj lobe,of
R2039 T8374 T8373 amod accessory,lobe
R2040 T8375 T8357 punct ", ",was
R2041 T8376 T8357 cc and,was
R2042 T8377 T8378 det the,weights
R2043 T8378 T8379 nsubj weights,were
R2044 T8379 T8357 conj were,was
R2045 T8380 T8378 prep of,weights
R2046 T8381 T8382 compound mutant,lungs
R2047 T8382 T8380 pobj lungs,of
R2048 T8383 T8382 acl cultured,lungs
R2049 T8384 T8383 prep for,cultured
R2050 T8385 T8386 nummod 5,d
R2051 T8386 T8384 pobj d,for
R2052 T8387 T8388 advmod significantly,lower
R2053 T8388 T8379 acomp lower,were
R2054 T8389 T8388 prep than,lower
R2055 T8390 T8389 pobj those,than
R2056 T8391 T8390 prep of,those
R2057 T8392 T8393 compound littermate,controls
R2058 T8393 T8391 pobj controls,of
R2059 T8394 T8395 punct (,Figure
R2060 T8395 T8379 parataxis Figure,were
R2061 T8396 T8395 nummod 4,Figure
R2062 T8397 T8395 punct ),Figure
R2063 T8398 T8357 punct .,was
R2064 T8400 T8401 det These,data
R2065 T8401 T8402 nsubj data,demonstrate
R2066 T8403 T8404 mark that,is
R2067 T8404 T8402 ccomp is,demonstrate
R2068 T8405 T8406 det the,hypoplasia
R2069 T8406 T8404 nsubj hypoplasia,is
R2070 T8407 T8406 amod pulmonary,hypoplasia
R2071 T8408 T8406 prep in,hypoplasia
R2072 T8409 T8410 compound Fog2,mice
R2073 T8410 T8408 pobj mice,in
R2074 T8411 T8410 compound mutant,mice
R2075 T8412 T8413 det a,defect
R2076 T8413 T8404 attr defect,is
R2077 T8414 T8413 amod primary,defect
R2078 T8415 T8402 punct .,demonstrate
R2079 T8417 T8418 nsubj Branching,appeared
R2080 T8419 T8417 prep in,Branching
R2081 T8420 T8421 det the,lobes
R2082 T8421 T8419 pobj lobes,in
R2083 T8422 T8421 amod unaffected,lobes
R2084 T8423 T8424 aux to,delayed
R2085 T8424 T8418 xcomp delayed,appeared
R2086 T8425 T8424 auxpass be,delayed
R2087 T8426 T8424 prep by,delayed
R2088 T8427 T8428 quantmod 6,12
R2089 T8428 T8430 nummod 12,h
R2090 T8429 T8428 punct –,12
R2091 T8430 T8426 pobj h,by
R2092 T8431 T8418 punct ", ",appeared
R2093 T8432 T8418 cc but,appeared
R2094 T8433 T8434 det all,mutants
R2095 T8434 T8435 nsubj mutants,developed
R2096 T8435 T8418 conj developed,appeared
R2097 T8436 T8437 det an,pattern
R2098 T8437 T8435 dobj pattern,developed
R2099 T8438 T8437 amod intricate,pattern
R2100 T8439 T8437 compound branching,pattern
R2101 T8440 T8435 prep in,developed
R2102 T8441 T8442 det the,lobes
R2103 T8442 T8440 pobj lobes,in
R2104 T8443 T8442 amod unaffected,lobes
R2105 T8444 T8435 prep after,developed
R2106 T8445 T8444 pobj culture,after
R2107 T8446 T8445 prep for,culture
R2108 T8447 T8448 nummod 5,d
R2109 T8448 T8446 pobj d,for
R2110 T8449 T8435 punct .,developed
R2111 T8451 T8452 mark Because,is
R2112 T8452 T8456 advcl is,evaluated
R2113 T8453 T8454 det the,phenotype
R2114 T8454 T8452 nsubj phenotype,is
R2115 T8455 T8454 compound Fog2,phenotype
R2116 T8457 T8452 acomp striking,is
R2117 T8458 T8457 prep for,striking
R2118 T8459 T8460 amod specific,loss
R2119 T8460 T8458 pobj loss,for
R2120 T8461 T8460 compound lobar,loss
R2121 T8462 T8456 punct ", ",evaluated
R2122 T8463 T8464 det the,pattern
R2123 T8464 T8456 nsubjpass pattern,evaluated
R2124 T8465 T8464 amod spatial,pattern
R2125 T8466 T8464 prep of,pattern
R2126 T8467 T8468 compound Fog2,expression
R2127 T8468 T8466 pobj expression,of
R2128 T8469 T8456 auxpass was,evaluated
R2129 T8470 T8456 prep in,evaluated
R2130 T8471 T8472 amod normal,embryos
R2131 T8472 T8470 pobj embryos,in
R2132 T8473 T8456 prep during,evaluated
R2133 T8474 T8475 det the,period
R2134 T8475 T8473 pobj period,during
R2135 T8476 T8475 prep of,period
R2136 T8477 T8478 amod early,establishment
R2137 T8478 T8476 pobj establishment,of
R2138 T8479 T8478 compound lobar,establishment
R2139 T8480 T8481 aux to,determine
R2140 T8481 T8456 advcl determine,evaluated
R2141 T8482 T8483 mark whether,is
R2142 T8483 T8481 ccomp is,determine
R2143 T8484 T8485 compound Fog2,expression
R2144 T8485 T8483 nsubj expression,is
R2145 T8486 T8487 advmod specifically,different
R2146 T8487 T8483 acomp different,is
R2147 T8488 T8483 prep at,is
R2148 T8489 T8490 det these,buds
R2149 T8490 T8488 pobj buds,at
R2150 T8491 T8490 compound lobar,buds
R2151 T8492 T8456 punct .,evaluated
R2152 T8494 T8495 nsubjpass Expression,evaluated
R2153 T8496 T8495 auxpass was,evaluated
R2154 T8497 T8495 prep in,evaluated
R2155 T8498 T8497 pobj mice,in
R2156 T8499 T8498 acl carrying,mice
R2157 T8500 T8501 det a,gene
R2158 T8501 T8499 dobj gene,carrying
R2159 T8502 T8501 compound lacZ,gene
R2160 T8503 T8501 acl incorporated,gene
R2161 T8504 T8503 prep into,incorporated
R2162 T8505 T8506 det the,locus
R2163 T8506 T8504 pobj locus,into
R2164 T8507 T8506 compound Fog2,locus
R2165 T8508 T8509 punct (,S.
R2166 T8509 T8495 meta S.,evaluated
R2167 T8510 T8509 nmod Tevosian,S.
R2168 T8511 T8509 punct ", ",S.
R2169 T8512 T8509 amod unpublished,S.
R2170 T8513 T8509 nmod data,S.
R2171 T8514 T8509 punct ),S.
R2172 T8515 T8495 punct .,evaluated
R2173 T8517 T8518 prep In,showed
R2174 T8519 T8520 nummod nine,mice
R2175 T8520 T8517 pobj mice,In
R2176 T8521 T8520 acl examined,mice
R2177 T8522 T8521 prep at,examined
R2178 T8523 T8522 pobj E11.5,at
R2179 T8524 T8518 punct ", ",showed
R2180 T8525 T8526 det all,lungs
R2181 T8526 T8518 nsubj lungs,showed
R2182 T8527 T8528 det a,enhancement
R2183 T8528 T8518 dobj enhancement,showed
R2184 T8529 T8528 amod specific,enhancement
R2185 T8530 T8528 prep of,enhancement
R2186 T8531 T8532 compound Fog2,expression
R2187 T8532 T8530 pobj expression,of
R2188 T8533 T8518 prep in,showed
R2189 T8534 T8535 det the,mesenchyme
R2190 T8535 T8533 pobj mesenchyme,in
R2191 T8536 T8535 acl surrounding,mesenchyme
R2192 T8537 T8538 det the,bud
R2193 T8538 T8536 dobj bud,surrounding
R2194 T8539 T8538 amod accessory,bud
R2195 T8540 T8538 cc and,bud
R2196 T8541 T8542 det the,bud
R2197 T8542 T8538 conj bud,bud
R2198 T8543 T8542 amod right,bud
R2199 T8544 T8542 amod middle,bud
R2200 T8545 T8542 compound lobe,bud
R2201 T8546 T8538 punct ", ",bud
R2202 T8547 T8548 dep which,are
R2203 T8548 T8538 relcl are,bud
R2204 T8549 T8550 det the,lobes
R2205 T8550 T8548 attr lobes,are
R2206 T8551 T8552 dep that,develop
R2207 T8552 T8550 relcl develop,lobes
R2208 T8553 T8552 aux do,develop
R2209 T8554 T8552 neg not,develop
R2210 T8555 T8552 advmod normally,develop
R2211 T8556 T8552 prep in,develop
R2212 T8557 T8558 compound Fog2,mice
R2213 T8558 T8556 pobj mice,in
R2214 T8559 T8558 compound mutant,mice
R2215 T8560 T8561 punct (,Figure
R2216 T8561 T8518 parataxis Figure,showed
R2217 T8562 T8561 nummod 5,Figure
R2218 T8563 T8561 punct ),Figure
R2219 T8564 T8518 punct .,showed
R2220 T8566 T8567 prep By,was
R2221 T8568 T8566 pobj E12.5,By
R2222 T8569 T8567 punct ", ",was
R2223 T8570 T8567 nsubj expression,was
R2224 T8571 T8567 acomp diffuse,was
R2225 T8572 T8567 prep in,was
R2226 T8573 T8574 det the,mesenchyme
R2227 T8574 T8572 pobj mesenchyme,in
R2228 T8575 T8574 amod pulmonary,mesenchyme
R2229 T8576 T8567 punct ", ",was
R2230 T8577 T8578 mark as,seen
R2231 T8578 T8567 advcl seen,was
R2232 T8579 T8578 auxpass was,seen
R2233 T8580 T8578 advmod previously,seen
R2234 T8581 T8578 prep with,seen
R2235 T8582 T8583 advmod in,situ
R2236 T8583 T8584 amod situ,hybridization
R2237 T8584 T8581 pobj hybridization,with
R2238 T8585 T8584 prep on,hybridization
R2239 T8586 T8587 compound tissue,sections
R2240 T8587 T8585 pobj sections,on
R2241 T8588 T8567 punct .,was
R2242 T8590 T8591 nsubj Diaphragms,show
R2243 T8592 T8590 prep from,Diaphragms
R2244 T8593 T8594 compound Fog2,mice
R2245 T8594 T8592 pobj mice,from
R2246 T8595 T8594 compound lil,mice
R2247 T8596 T8597 det an,membrane
R2248 T8597 T8591 dobj membrane,show
R2249 T8598 T8597 amod intact,membrane
R2250 T8599 T8597 prep with,membrane
R2251 T8600 T8601 det a,defect
R2252 T8601 T8599 pobj defect,with
R2253 T8602 T8601 prep in,defect
R2254 T8603 T8604 amod muscular,patterning
R2255 T8604 T8602 pobj patterning,in
R2256 T8605 T8606 punct (,see
R2257 T8606 T8591 parataxis see,show
R2258 T8607 T8606 dobj Figure,see
R2259 T8608 T8607 nummod 1B,Figure
R2260 T8609 T8606 punct ),see
R2261 T8610 T8591 punct .,show
R2262 T8612 T8613 det The,portion
R2263 T8613 T8615 nsubjpass portion,populated
R2264 T8614 T8613 amod membranous,portion
R2265 T8658 T8656 cc but,intact
R2266 T8659 T8656 conj amuscular,intact
R2267 T8616 T8613 prep of,portion
R2268 T8660 T8661 punct [,22
R2269 T8661 T8641 parataxis 22,have
R2270 T8662 T8661 nummod 17,22
R2271 T8617 T8618 det the,diaphragm
R2272 T8663 T8661 punct ",",22
R2273 T8664 T8661 nummod 21,22
R2274 T8665 T8661 punct ",",22
R2275 T8618 T8616 pobj diaphragm,of
R2276 T8666 T8661 punct ],22
R2277 T8667 T8641 punct .,have
R2278 T8619 T8615 auxpass is,populated
R2279 T8669 T8670 compound Hepatocyte,factor
R2280 T8670 T8672 nsubj factor,is
R2281 T8620 T8615 agent by,populated
R2282 T8671 T8670 compound growth,factor
R2283 T8673 T8670 punct /,factor
R2284 T8621 T8622 det a,population
R2285 T8674 T8675 compound Scatter,factor
R2286 T8675 T8670 appos factor,factor
R2287 T8676 T8670 punct (,factor
R2288 T8622 T8620 pobj population,by
R2289 T8677 T8670 appos HGF,factor
R2290 T8678 T8672 punct ),is
R2291 T8679 T8680 nummod one,candidate
R2292 T8623 T8622 amod migratory,population
R2293 T8680 T8672 attr candidate,is
R2294 T8681 T8680 amod potential,candidate
R2295 T8624 T8622 prep of,population
R2296 T8682 T8680 amod responsible,candidate
R2297 T8683 T8682 prep for,responsible
R2298 T8684 T8685 det the,guidance
R2299 T8625 T8626 compound muscle,cells
R2300 T8685 T8683 pobj guidance,for
R2301 T8686 T8685 prep of,guidance
R2302 T8687 T8688 compound muscle,precursors
R2303 T8626 T8624 pobj cells,of
R2304 T8688 T8686 pobj precursors,of
R2305 T8689 T8688 prep to,precursors
R2306 T8627 T8626 compound precursor,cells
R2307 T8690 T8691 det the,diaphragm
R2308 T8691 T8689 pobj diaphragm,to
R2309 T8692 T8691 amod membranous,diaphragm
R2310 T8628 T8615 punct ", ",populated
R2311 T8693 T8672 punct .,is
R2312 T8629 T8630 advmod much,like
R2313 T8695 T8696 nsubjpass It,shown
R2314 T8697 T8696 aux has,shown
R2315 T8630 T8615 prep like,populated
R2316 T8698 T8696 auxpass been,shown
R2317 T8631 T8632 det the,limbs
R2318 T8699 T8700 mark that,expressed
R2319 T8700 T8696 ccomp expressed,shown
R2320 T8701 T8700 nsubjpass HGF,expressed
R2321 T8702 T8700 auxpass is,expressed
R2322 T8632 T8630 pobj limbs,like
R2323 T8703 T8700 prep along,expressed
R2324 T8704 T8705 det this,pathway
R2325 T8633 T8634 punct [,20
R2326 T8705 T8703 pobj pathway,along
R2327 T8706 T8705 amod anatomic,pathway
R2328 T8707 T8708 punct [,23
R2329 T8634 T8615 parataxis 20,populated
R2330 T8708 T8696 parataxis 23,shown
R2331 T8709 T8708 punct ],23
R2332 T8635 T8634 nummod 19,20
R2333 T8710 T8696 punct ", ",shown
R2334 T8711 T8696 cc and,shown
R2335 T8712 T8713 nsubj mice,fail
R2336 T8636 T8634 punct ",",20
R2337 T8713 T8696 conj fail,shown
R2338 T8714 T8712 prep with,mice
R2339 T8637 T8634 punct ],20
R2340 T8715 T8714 pobj absence,with
R2341 T8716 T8715 prep of,absence
R2342 T8717 T8718 det the,receptor
R2343 T8638 T8615 punct .,populated
R2344 T8718 T8716 pobj receptor,of
R2345 T8719 T8718 compound HGF,receptor
R2346 T8720 T8721 compound c,Met
R2347 T8640 T8641 nsubj Mice,have
R2348 T8721 T8718 appos Met,receptor
R2349 T8722 T8721 punct -,Met
R2350 T8723 T8724 aux to,form
R2351 T8724 T8713 xcomp form,fail
R2352 T8725 T8726 amod muscularized,folds
R2353 T8642 T8640 prep with,Mice
R2354 T8726 T8724 dobj folds,form
R2355 T8727 T8726 amod pleuroperitoneal,folds
R2356 T8728 T8726 punct (,folds
R2357 T8729 T8726 appos PPFs,folds
R2358 T8643 T8642 pobj defects,with
R2359 T8730 T8713 punct ),fail
R2360 T8644 T8643 prep in,defects
R2361 T8731 T8713 punct ", ",fail
R2362 T8732 T8713 cc and,fail
R2363 T8733 T8734 advmod thus,have
R2364 T8645 T8644 pobj genes,in
R2365 T8734 T8713 conj have,fail
R2366 T8735 T8736 amod amuscular,diaphragms
R2367 T8736 T8734 dobj diaphragms,have
R2368 T8646 T8645 acl known,genes
R2369 T8737 T8738 punct [,25
R2370 T8738 T8734 parataxis 25,have
R2371 T8739 T8738 nummod 24,25
R2372 T8740 T8738 punct ",",25
R2373 T8741 T8738 punct ],25
R2374 T8742 T8713 punct .,fail
R2375 T8647 T8648 aux to,be
R2376 T8744 T8745 nsubjpass Fog2,expressed
R2377 T8746 T8745 auxpass is,expressed
R2378 T8648 T8646 xcomp be,known
R2379 T8747 T8745 advmod diffusely,expressed
R2380 T8748 T8745 prep in,expressed
R2381 T8649 T8648 acomp important,be
R2382 T8650 T8649 prep for,important
R2383 T8749 T8750 det the,diaphragm
R2384 T8651 T8652 det the,control
R2385 T8750 T8748 pobj diaphragm,in
R2386 T8751 T8750 amod early,diaphragm
R2387 T8652 T8650 pobj control,for
R2388 T8752 T8750 amod amuscular,diaphragm
R2389 T8753 T8750 prep at,diaphragm
R2390 T8653 T8652 prep of,control
R2391 T8754 T8753 pobj E11.5,at
R2392 T8755 T8756 advmod as,as
R2393 T8756 T8748 cc as,in
R2394 T8654 T8655 det this,process
R2395 T8757 T8756 advmod well,as
R2396 T8758 T8748 conj in,in
R2397 T8759 T8760 det the,diaphragm
R2398 T8655 T8653 pobj process,of
R2399 T8760 T8758 pobj diaphragm,in
R2400 T8761 T8760 amod later,diaphragm
R2401 T8762 T8760 amod muscularized,diaphragm
R2402 T8656 T8657 amod intact,diaphragms
R2403 T8657 T8641 dobj diaphragms,have
R2404 T8869 T8867 pobj path,along
R2405 T8763 T8764 punct (,see
R2406 T8870 T8869 prep of,path
R2407 T8764 T8745 parataxis see,expressed
R2408 T8765 T8766 nmod Figure,3C
R2409 T8871 T8872 compound muscle,cell
R2410 T8766 T8764 dobj 3C,see
R2411 T8767 T8766 cc and,3C
R2412 T8768 T8766 conj 3D,3C
R2413 T8872 T8874 compound cell,migration
R2414 T8769 T8764 punct ),see
R2415 T8770 T8745 punct .,expressed
R2416 T8873 T8872 compound precursor,cell
R2417 T8772 T8773 nsubjpass Pax3,detected
R2418 T8874 T8870 pobj migration,of
R2419 T8774 T8772 cc and,Pax3
R2420 T8775 T8772 conj MyoD,Pax3
R2421 T8776 T8772 punct ", ",Pax3
R2422 T8777 T8778 compound transcription,factors
R2423 T8778 T8772 appos factors,Pax3
R2424 T8779 T8778 acl required,factors
R2425 T8875 T8869 prep between,path
R2426 T8780 T8779 prep for,required
R2427 T8781 T8782 amod appropriate,migration
R2428 T8782 T8780 pobj migration,for
R2429 T8783 T8782 cc and,migration
R2430 T8876 T8877 det the,PPF
R2431 T8877 T8875 pobj PPF,between
R2432 T8784 T8782 conj determination,migration
R2433 T8878 T8877 cc and,PPF
R2434 T8785 T8782 prep of,migration
R2435 T8786 T8787 amod myogenic,precursors
R2436 T8787 T8785 pobj precursors,of
R2437 T8879 T8880 det the,diaphragm
R2438 T8788 T8773 punct ", ",detected
R2439 T8789 T8773 auxpass were,detected
R2440 T8790 T8773 prep in,detected
R2441 T8880 T8877 conj diaphragm,PPF
R2442 T8791 T8792 det the,PPFs
R2443 T8792 T8790 pobj PPFs,in
R2444 T8881 T8863 prep for,accounts
R2445 T8793 T8792 prep of,PPFs
R2446 T8794 T8795 compound Fog2,mice
R2447 T8795 T8793 pobj mice,of
R2448 T8796 T8795 compound lil,mice
R2449 T8882 T8883 det the,phenotype
R2450 T8797 T8798 punct (,shown
R2451 T8798 T8773 parataxis shown,detected
R2452 T8799 T8798 nsubj data,shown
R2453 T8883 T8881 pobj phenotype,for
R2454 T8800 T8798 neg not,shown
R2455 T8801 T8798 punct ),shown
R2456 T8884 T8883 amod abnormal,phenotype
R2457 T8802 T8773 punct .,detected
R2458 T8804 T8805 advmod However,demonstrated
R2459 T8885 T8863 prep in,accounts
R2460 T8806 T8805 punct ", ",demonstrated
R2461 T8807 T8808 advmod in,situ
R2462 T8886 T8887 det these,mice
R2463 T8808 T8809 amod situ,analysis
R2464 T8809 T8805 nsubj analysis,demonstrated
R2465 T8810 T8809 compound expression,analysis
R2466 T8887 T8885 pobj mice,in
R2467 T8811 T8812 mark that,reduced
R2468 T8812 T8805 ccomp reduced,demonstrated
R2469 T8813 T8814 det the,expression
R2470 T8888 T8863 punct .,accounts
R2471 T8814 T8812 nsubjpass expression,reduced
R2472 T8815 T8814 prep of,expression
R2473 T8816 T8815 pobj HGF,of
R2474 T8817 T8814 prep in,expression
R2475 T8818 T8819 det the,region
R2476 T8819 T8817 pobj region,in
R2477 T8820 T8821 advmod where,meets
R2478 T8821 T8819 relcl meets,region
R2479 T8822 T8823 det this,structure
R2480 T8823 T8821 nsubj structure,meets
R2481 T8824 T8825 det the,diaphragm
R2482 T8825 T8821 dobj diaphragm,meets
R2483 T8826 T8825 amod membranous,diaphragm
R2484 T8827 T8812 auxpass was,reduced
R2485 T8828 T8812 advmod markedly,reduced
R2486 T8829 T8812 prep in,reduced
R2487 T8830 T8831 compound Fog2,mice
R2488 T8831 T8829 pobj mice,in
R2489 T8832 T8831 compound mutant,mice
R2490 T8833 T8834 punct (,Figure
R2491 T8834 T8805 parataxis Figure,demonstrated
R2492 T8835 T8834 nummod 6,Figure
R2493 T8836 T8834 punct ),Figure
R2494 T8837 T8805 punct .,demonstrated
R2495 T8839 T8840 nsubj We,hypothesize
R2496 T8841 T8842 mark that,required
R2497 T8842 T8840 ccomp required,hypothesize
R2498 T8843 T8842 nsubjpass Fog2,required
R2499 T8844 T8842 auxpass is,required
R2500 T8845 T8842 punct (,required
R2501 T8846 T8847 preconj either,directly
R2502 T8847 T8842 advmod directly,required
R2503 T8848 T8847 cc or,directly
R2504 T8849 T8847 conj indirectly,directly
R2505 T8850 T8842 punct ),required
R2506 T8851 T8842 prep for,required
R2507 T8852 T8853 det the,induction
R2508 T8853 T8851 pobj induction,for
R2509 T8854 T8853 prep of,induction
R2510 T8855 T8854 pobj HGF,of
R2511 T8856 T8853 prep in,induction
R2512 T8857 T8858 det the,diaphragm
R2513 T8858 T8856 pobj diaphragm,in
R2514 T8859 T8858 amod developing,diaphragm
R2515 T8860 T8840 punct ", ",hypothesize
R2516 T8861 T8840 cc and,hypothesize
R2517 T8862 T8863 nsubj dysregulation,accounts
R2518 T8863 T8840 conj accounts,hypothesize
R2519 T8864 T8862 prep of,dysregulation
R2520 T8865 T8866 compound HGF,patterning
R2521 T8866 T8864 pobj patterning,of
R2522 T8867 T8866 prep along,patterning
R2523 T8868 T8869 det the,path
R2526 T9907 T9908 compound FOG2,Mutation
R2527 T9909 T9908 prep in,Mutation
R2528 T9910 T9911 det a,Patient
R2529 T9911 T9909 pobj Patient,in
R2530 T9912 T9911 prep with,Patient
R2531 T9913 T9914 nmod Diaphragm,Abnormalities
R2532 T9914 T9912 pobj Abnormalities,with
R2533 T9915 T9913 cc and,Diaphragm
R2534 T9916 T9913 conj Lung,Diaphragm
R2535 T9918 T9919 compound FOG2,analysis
R2536 T9919 T9921 nsubjpass analysis,performed
R2537 T9920 T9919 compound sequence,analysis
R2538 T9922 T9921 auxpass was,performed
R2539 T9923 T9921 prep on,performed
R2540 T9924 T9925 compound autopsy,tissue
R2541 T9925 T9923 pobj tissue,on
R2542 T9926 T9925 prep from,tissue
R2543 T9927 T9928 quantmod 30,32
R2544 T9928 T9930 nummod 32,children
R2545 T9929 T9928 quantmod of,32
R2546 T9930 T9926 pobj children,from
R2547 T9931 T9930 amod deceased,children
R2548 T9932 T9930 prep with,children
R2549 T9933 T9934 det an,diagnosis
R2550 T9934 T9932 pobj diagnosis,with
R2551 T9935 T9934 amod anatomic,diagnosis
R2552 T9936 T9934 prep of,diagnosis
R2553 T9937 T9938 amod diaphragmatic,defect
R2554 T9938 T9936 pobj defect,of
R2555 T9939 T9925 acl evaluated,tissue
R2556 T9940 T9939 prep at,evaluated
R2557 T9941 T9942 det the,Hospital
R2558 T9942 T9940 pobj Hospital,at
R2559 T9943 T9942 poss Children,Hospital
R2560 T9944 T9943 case 's,Children
R2561 T9945 T9942 prep in,Hospital
R2562 T9946 T9945 pobj Boston,in
R2563 T9947 T9946 punct ", ",Boston
R2564 T9948 T9946 npadvmod Massachusetts,Boston
R2565 T9949 T9939 punct ", ",evaluated
R2566 T9950 T9939 prep between,evaluated
R2567 T9951 T9950 pobj 1993,between
R2568 T9952 T9951 cc and,1993
R2569 T9953 T9951 conj 2003,1993
R2570 T9954 T9921 punct .,performed
R2571 T9956 T9957 compound Autopsy,reports
R2572 T9957 T9958 nsubjpass reports,reviewed
R2573 T9959 T9958 auxpass were,reviewed
R2574 T9960 T9961 aux to,determine
R2575 T9961 T9958 advcl determine,reviewed
R2576 T9962 T9963 det the,diagnoses
R2577 T9963 T9961 dobj diagnoses,determine
R2578 T9964 T9963 amod specific,diagnoses
R2579 T9965 T9958 punct .,reviewed
R2580 T9967 T9968 prep Of,had
R2581 T9969 T9970 det these,cases
R2582 T9970 T9967 pobj cases,Of
R2583 T9971 T9970 nummod 30,cases
R2584 T9972 T9968 punct ", ",had
R2585 T9973 T9968 nsubj 17,had
R2586 T9974 T9975 punct (,%
R2587 T9975 T9973 parataxis %,17
R2588 T9976 T9975 nummod 57,%
R2589 T9977 T9975 punct ),%
R2590 T9978 T9979 compound Bochdalek,CDH
R2591 T9979 T9968 dobj CDH,had
R2592 T9980 T9968 punct ", ",had
R2593 T9981 T9982 nsubj two,had
R2594 T9982 T9968 conj had,had
R2595 T9983 T9984 punct (,%
R2596 T9984 T9981 parataxis %,two
R2597 T9985 T9984 nummod 7,%
R2598 T9986 T9984 punct ),%
R2599 T9987 T9988 amod diaphragmatic,agenesis
R2600 T9988 T9982 dobj agenesis,had
R2601 T9989 T9982 punct ", ",had
R2602 T9990 T9991 nsubj seven,had
R2603 T9991 T9982 conj had,had
R2604 T9992 T9993 punct (,%
R2605 T9993 T9990 parataxis %,seven
R2606 T9994 T9993 nummod 23,%
R2607 T9995 T9993 punct ),%
R2608 T9996 T9997 amod diaphragmatic,eventration
R2609 T9997 T9991 dobj eventration,had
R2610 T9998 T9997 punct /,eventration
R2611 T9999 T10000 compound muscularization,defects
R2612 T10000 T9997 appos defects,eventration
R2613 T10001 T9997 punct (,eventration
R2614 T10002 T9997 prep without,eventration
R2615 T10003 T10004 compound Bochdalek,CDH
R2616 T10004 T10002 pobj CDH,without
R2617 T10005 T9991 punct ),had
R2618 T10006 T9991 punct ", ",had
R2619 T10007 T9991 cc and,had
R2620 T10008 T10009 nsubj four,had
R2621 T10009 T9991 conj had,had
R2622 T10010 T10011 punct (,%
R2623 T10011 T10008 parataxis %,four
R2624 T10012 T10011 nummod 13,%
R2625 T10013 T10011 punct ),%
R2626 T10014 T10015 compound Bochdalek,hernia
R2627 T10015 T10009 dobj hernia,had
R2628 T10016 T10015 prep of,hernia
R2629 T10017 T10018 nummod one,hemidiaphragm
R2630 T10018 T10016 pobj hemidiaphragm,of
R2631 T10019 T10015 cc and,hernia
R2632 T10020 T10015 conj eventration,hernia
R2633 T10021 T10020 prep of,eventration
R2634 T10022 T10023 det the,other
R2635 T10023 T10021 pobj other,of
R2636 T10024 T10009 punct .,had
R2637 T10026 T10027 amod Pulmonary,hypoplasia
R2638 T10027 T10028 nsubjpass hypoplasia,assessed
R2639 T10029 T10028 auxpass was,assessed
R2640 T10030 T10028 advcl using,assessed
R2641 T10031 T10032 compound lung,body
R2642 T10032 T10034 compound body,ratio
R2643 T10033 T10032 punct /,body
R2644 T10034 T10030 dobj ratio,using
R2645 T10035 T10034 compound weight,ratio
R2646 T10036 T10034 cc and,ratio
R2647 T10037 T10038 amod radial,counts
R2648 T10038 T10034 conj counts,ratio
R2649 T10039 T10038 amod alveolar,counts
R2650 T10040 T10041 punct [,26
R2651 T10041 T10028 parataxis 26,assessed
R2652 T10042 T10041 punct ],26
R2653 T10043 T10028 punct .,assessed
R2654 T10045 T10046 det The,material
R2655 T10046 T10047 nsubj material,included
R2656 T10048 T10046 amod available,material
R2657 T10049 T10048 prep for,available
R2658 T10050 T10049 pobj review,for
R2659 T10051 T10052 amod written,reports
R2660 T10052 T10047 dobj reports,included
R2661 T10053 T10052 cc and,reports
R2662 T10054 T10055 amod histologic,slides
R2663 T10055 T10052 conj slides,reports
R2664 T10056 T10047 prep in,included
R2665 T10057 T10058 det all,cases
R2666 T10058 T10056 pobj cases,in
R2667 T10059 T10047 cc and,included
R2668 T10060 T10061 amod gross,kodachromes
R2669 T10061 T10047 conj kodachromes,included
R2670 T10062 T10061 prep in,kodachromes
R2671 T10063 T10064 det a,subset
R2672 T10064 T10062 pobj subset,in
R2673 T10065 T10064 prep of,subset
R2674 T10066 T10065 pobj cases,of
R2675 T10067 T10047 punct .,included
R2676 T10069 T10070 nummod One,child
R2677 T10070 T10071 nsubj child,carried
R2678 T10072 T10073 det a,change
R2679 T10073 T10071 dobj change,carried
R2680 T10074 T10075 advmod highly,significant
R2681 T10075 T10073 amod significant,change
R2682 T10076 T10073 compound FOG2,change
R2683 T10077 T10073 compound sequence,change
R2684 T10078 T10071 punct .,carried
R2685 T10080 T10081 det The,patient
R2686 T10081 T10082 nsubj patient,was
R2687 T10083 T10084 det a,girl
R2688 T10084 T10082 attr girl,was
R2689 T10085 T10086 amod full,term
R2690 T10086 T10084 nmod term,girl
R2691 T10087 T10086 punct -,term
R2692 T10088 T10089 nummod "3,500",g
R2693 T10089 T10084 compound g,girl
R2694 T10090 T10089 punct -,g
R2695 T10091 T10084 compound baby,girl
R2696 T10092 T10093 dep who,developed
R2697 T10093 T10084 relcl developed,girl
R2698 T10094 T10095 amod severe,failure
R2699 T10095 T10093 dobj failure,developed
R2700 T10096 T10095 amod respiratory,failure
R2701 T10097 T10093 prep at,developed
R2702 T10098 T10097 pobj birth,at
R2703 T10099 T10093 cc and,developed
R2704 T10100 T10093 conj died,developed
R2705 T10101 T10100 prep after,died
R2706 T10102 T10103 nummod 5,h
R2707 T10103 T10101 pobj h,after
R2708 T10104 T10103 prep of,h
R2709 T10105 T10104 pobj resuscitation,of
R2710 T10106 T10082 punct .,was
R2711 T10108 T10109 compound Antemortem,radiographs
R2712 T10109 T10110 nsubj radiographs,showed
R2713 T10111 T10112 amod opacified,fields
R2714 T10112 T10110 dobj fields,showed
R2715 T10113 T10112 compound lung,fields
R2716 T10114 T10112 cc and,fields
R2717 T10115 T10116 amod possible,bowel
R2718 T10116 T10112 conj bowel,fields
R2719 T10117 T10116 prep in,bowel
R2720 T10118 T10119 det the,chest
R2721 T10119 T10117 pobj chest,in
R2722 T10120 T10110 punct .,showed
R2723 T10122 T10123 det The,patient
R2724 T10123 T10124 poss patient,diagnosis
R2725 T10124 T10127 nsubj diagnosis,was
R2726 T10125 T10123 case 's,patient
R2727 T10126 T10124 amod clinical,diagnosis
R2728 T10128 T10127 attr CDH,was
R2729 T10129 T10127 punct .,was
R2730 T10131 T10132 nsubj Review,revealed
R2731 T10133 T10131 prep of,Review
R2732 T10134 T10135 compound autopsy,material
R2733 T10135 T10133 pobj material,of
R2734 T10136 T10137 amod severe,hypoplasia
R2735 T10137 T10132 dobj hypoplasia,revealed
R2736 T10138 T10137 amod bilateral,hypoplasia
R2737 T10139 T10137 amod pulmonary,hypoplasia
R2738 T10140 T10141 punct (,27
R2739 T10141 T10137 parataxis 27,hypoplasia
R2740 T10142 T10143 amod combined,weight
R2741 T10143 T10145 dep weight,g
R2742 T10144 T10143 compound lung,weight
R2743 T10145 T10141 dep g,27
R2744 T10146 T10145 punct ", ",g
R2745 T10147 T10145 nummod 11.1,g
R2746 T10148 T10141 punct ;,27
R2747 T10149 T10141 dep expected,27
R2748 T10150 T10149 prep for,expected
R2749 T10151 T10152 compound body,weight
R2750 T10152 T10150 pobj weight,for
R2751 T10153 T10152 compound length,weight
R2752 T10154 T10152 punct /,weight
R2753 T10155 T10149 punct ", ",expected
R2754 T10156 T10157 quantmod 46.8,26.2
R2755 T10157 T10159 nummod 26.2,g
R2756 T10158 T10157 punct ±,26.2
R2757 T10159 T10149 dep g,expected
R2758 T10160 T10141 punct ;,27
R2759 T10161 T10141 punct [,27
R2760 T10162 T10141 punct ],27
R2761 T10163 T10141 punct ),27
R2762 T10164 T10137 punct ", ",hypoplasia
R2763 T10165 T10166 advmod most,markedly
R2764 T10166 T10167 advmod markedly,involving
R2765 T10167 T10137 acl involving,hypoplasia
R2766 T10168 T10169 det the,lung
R2767 T10169 T10167 dobj lung,involving
R2768 T10170 T10169 amod left,lung
R2769 T10171 T10132 punct .,revealed
R2770 T10173 T10174 det The,ratio
R2771 T10174 T10179 nsubj ratio,was
R2772 T10175 T10174 nmod lung,ratio
R2773 T10176 T10177 punct /,body
R2774 T10177 T10175 prep body,lung
R2775 T10178 T10174 compound weight,ratio
R2776 T10180 T10179 attr 0.0037,was
R2777 T10181 T10182 punct (,0.010
R2778 T10182 T10179 parataxis 0.010,was
R2779 T10183 T10182 nsubj expected,0.010
R2780 T10184 T10182 punct >,0.010
R2781 T10185 T10182 punct ),0.010
R2782 T10186 T10187 punct [,28
R2783 T10187 T10179 parataxis 28,was
R2784 T10188 T10187 punct ],28
R2785 T10189 T10179 punct .,was
R2786 T10191 T10192 expl There,were
R2787 T10193 T10194 det a,number
R2788 T10194 T10192 attr number,were
R2789 T10195 T10194 amod reduced,number
R2790 T10196 T10194 prep of,number
R2791 T10197 T10198 amod bronchial,generations
R2792 T10198 T10196 pobj generations,of
R2793 T10199 T10192 punct ", ",were
R2794 T10200 T10192 cc and,were
R2795 T10201 T10202 det the,count
R2796 T10202 T10205 nsubj count,was
R2797 T10203 T10202 amod radial,count
R2798 T10204 T10202 amod alveolar,count
R2799 T10205 T10192 conj was,were
R2800 T10206 T10207 quantmod 2,3
R2801 T10207 T10205 attr 3,was
R2802 T10208 T10207 punct –,3
R2803 T10209 T10210 punct (,5
R2804 T10210 T10205 parataxis 5,was
R2805 T10211 T10210 nsubj expected,5
R2806 T10212 T10210 punct =,5
R2807 T10213 T10210 punct ),5
R2808 T10214 T10215 punct [,29
R2809 T10215 T10205 parataxis 29,was
R2810 T10216 T10215 punct ],29
R2811 T10217 T10205 punct .,was
R2812 T10219 T10220 expl There,were
R2813 T10221 T10222 amod incomplete,fissures
R2814 T10222 T10220 attr fissures,were
R2815 T10223 T10222 compound lung,fissures
R2816 T10224 T10220 advmod bilaterally,were
R2817 T10225 T10220 punct .,were
R2818 T10227 T10228 det A,eventration
R2819 T10228 T10232 nsubj eventration,was
R2820 T10229 T10228 amod deep,eventration
R2821 T10230 T10228 amod posterior,eventration
R2822 T10231 T10228 amod diaphragmatic,eventration
R2823 T10233 T10232 acomp present,was
R2824 T10234 T10232 prep on,was
R2825 T10235 T10236 det the,side
R2826 T10236 T10234 pobj side,on
R2827 T10237 T10236 amod left,side
R2828 T10238 T10232 punct .,was
R2829 T10240 T10241 advmod Additionally,encircled
R2830 T10242 T10241 punct ", ",encircled
R2831 T10243 T10244 nummod two,bands
R2832 T10244 T10241 nsubj bands,encircled
R2833 T10245 T10244 amod muscularized,bands
R2834 T10246 T10244 amod ligamentous,bands
R2835 T10247 T10244 acl resembling,bands
R2836 T10248 T10249 amod diaphragmatic,remnants
R2837 T10249 T10247 dobj remnants,resembling
R2838 T10250 T10251 det the,lobe
R2839 T10251 T10241 dobj lobe,encircled
R2840 T10252 T10251 amod left,lobe
R2841 T10253 T10251 prep of,lobe
R2842 T10254 T10255 det the,liver
R2843 T10255 T10253 pobj liver,of
R2844 T10256 T10241 punct ", ",encircled
R2845 T10257 T10241 advcl creating,encircled
R2846 T10258 T10259 det an,contour
R2847 T10259 T10257 dobj contour,creating
R2848 T10260 T10259 amod abnormal,contour
R2849 T10261 T10259 amod fissured,contour
R2850 T10262 T10259 compound liver,contour
R2851 T10263 T10241 punct .,encircled
R2852 T10265 T10266 advmod Away,appeared
R2853 T10267 T10265 prep from,Away
R2854 T10268 T10269 det the,eventration
R2855 T10269 T10267 pobj eventration,from
R2856 T10270 T10266 punct ", ",appeared
R2857 T10271 T10272 det the,diaphragm
R2858 T10272 T10266 nsubj diaphragm,appeared
R2859 T10273 T10274 advmod well,muscularized
R2860 T10274 T10266 oprd muscularized,appeared
R2861 T10275 T10266 punct ", ",appeared
R2862 T10276 T10266 advcl measuring,appeared
R2863 T10277 T10278 nummod 0.3,cm
R2864 T10278 T10276 dobj cm,measuring
R2865 T10279 T10278 prep in,cm
R2866 T10280 T10279 pobj thickness,in
R2867 T10281 T10266 punct .,appeared
R2868 T10283 T10284 det A,autopsy
R2869 T10284 T10286 nsubj autopsy,revealed
R2870 T10285 T10284 amod complete,autopsy
R2871 T10286 T10287 ccomp revealed,determined
R2872 T10288 T10289 det no,malformations
R2873 T10289 T10286 dobj malformations,revealed
R2874 T10290 T10289 amod other,malformations
R2875 T10291 T10287 punct ;,determined
R2876 T10292 T10293 det the,heart
R2877 T10293 T10287 nsubjpass heart,determined
R2878 T10294 T10287 auxpass was,determined
R2879 T10295 T10296 aux to,be
R2880 T10296 T10287 xcomp be,determined
R2881 T10297 T10298 advmod grossly,normal
R2882 T10298 T10296 acomp normal,be
R2883 T10299 T10287 cc and,determined
R2884 T10300 T10301 auxpass was,donated
R2885 T10301 T10287 conj donated,determined
R2886 T10302 T10301 prep for,donated
R2887 T10303 T10304 compound valve,harvest
R2888 T10304 T10302 pobj harvest,for
R2889 T10305 T10287 punct .,determined
R2890 T10307 T10308 compound Sequence,analysis
R2891 T10308 T10309 nsubj analysis,revealed
R2892 T10310 T10311 det a,change
R2893 T10311 T10309 dobj change,revealed
R2894 T10312 T10311 nmod cytosine,change
R2895 T10313 T10312 prep to,cytosine
R2896 T10314 T10313 pobj thymine,to
R2897 T10315 T10311 amod heterozygous,change
R2898 T10316 T10311 prep in,change
R2899 T10317 T10316 pobj exon,in
R2900 T10318 T10317 nummod 4,exon
R2901 T10319 T10320 dep that,changes
R2902 T10320 T10311 relcl changes,change
R2903 T10321 T10322 det the,acid
R2904 T10322 T10320 dobj acid,changes
R2905 T10323 T10322 amod 112th,acid
R2906 T10324 T10322 compound amino,acid
R2907 T10325 T10320 prep from,changes
R2908 T10326 T10325 pobj arginine,from
R2909 T10327 T10320 prep to,changes
R2910 T10328 T10329 det a,codon
R2911 T10329 T10327 pobj codon,to
R2912 T10330 T10329 compound stop,codon
R2913 T10331 T10309 punct .,revealed
R2914 T10333 T10334 det This,mutation
R2915 T10334 T10335 nsubj mutation,produces
R2916 T10336 T10337 det a,peptide
R2917 T10337 T10335 dobj peptide,produces
R2918 T10338 T10339 advmod severely,truncated
R2919 T10339 T10337 amod truncated,peptide
R2920 T10340 T10341 dep that,contain
R2921 T10341 T10337 relcl contain,peptide
R2922 T10342 T10341 aux does,contain
R2923 T10343 T10341 neg not,contain
R2924 T10344 T10345 compound zinc,finger
R2925 T10345 T10346 compound finger,domains
R2926 T10346 T10341 dobj domains,contain
R2927 T10347 T10348 punct (,Figure
R2928 T10348 T10335 parataxis Figure,produces
R2929 T10349 T10348 nummod 7,Figure
R2930 T10350 T10348 punct ),Figure
R2931 T10351 T10335 punct .,produces
R2932 T10353 T10354 det This,change
R2933 T10354 T10356 nsubj change,was
R2934 T10355 T10354 compound base,change
R2935 T10357 T10356 neg not,was
R2936 T10358 T10356 acomp present,was
R2937 T10359 T10356 prep in,was
R2938 T10360 T10361 det the,analysis
R2939 T10361 T10359 pobj analysis,in
R2940 T10362 T10361 prep of,analysis
R2941 T10363 T10362 pobj DNA,of
R2942 T10364 T10363 prep from,DNA
R2943 T10365 T10366 nummod 400,adults
R2944 T10366 T10364 pobj adults,from
R2945 T10367 T10366 amod normal,adults
R2946 T10368 T10356 punct .,was
R2947 T10370 T10371 aux To,assess
R2948 T10371 T10372 advcl assess,examined
R2949 T10373 T10374 det the,likelihood
R2950 T10374 T10371 dobj likelihood,assess
R2951 T10375 T10376 mark that,was
R2952 T10376 T10374 acl was,likelihood
R2953 T10377 T10378 det the,mutation
R2954 T10378 T10376 nsubj mutation,was
R2955 T10379 T10376 acomp causal,was
R2956 T10380 T10379 prep for,causal
R2957 T10381 T10382 det the,phenotype
R2958 T10382 T10380 pobj phenotype,for
R2959 T10383 T10382 amod developmental,phenotype
R2960 T10384 T10372 punct ", ",examined
R2961 T10385 T10372 nsubj we,examined
R2962 T10386 T10387 det both,parents
R2963 T10387 T10372 dobj parents,examined
R2964 T10388 T10372 punct .,examined
R2965 T10390 T10391 nsubjpass Paternity,confirmed
R2966 T10392 T10391 auxpass was,confirmed
R2967 T10393 T10391 punct ", ",confirmed
R2968 T10394 T10391 cc and,confirmed
R2969 T10395 T10396 compound sequence,analysis
R2970 T10396 T10397 nsubj analysis,revealed
R2971 T10397 T10391 conj revealed,confirmed
R2972 T10398 T10399 mark that,carried
R2973 T10399 T10397 ccomp carried,revealed
R2974 T10400 T10401 det the,parent
R2975 T10401 T10399 nsubj parent,carried
R2976 T10402 T10401 preconj neither,parent
R2977 T10403 T10404 det this,mutation
R2978 T10404 T10399 dobj mutation,carried
R2979 T10405 T10397 punct ", ",revealed
R2980 T10406 T10397 advcl proving,revealed
R2981 T10407 T10408 mark that,had
R2982 T10408 T10406 ccomp had,proving
R2983 T10409 T10410 det the,patient
R2984 T10410 T10408 nsubj patient,had
R2985 T10411 T10412 det a,mutation
R2986 T10412 T10408 dobj mutation,had
R2987 T10413 T10414 advmod de,novo
R2988 T10414 T10412 amod novo,mutation
R2989 T10415 T10408 prep in,had
R2990 T10416 T10415 pobj FOG2,in
R2991 T10417 T10418 punct (,Figure
R2992 T10418 T10397 parataxis Figure,revealed
R2993 T10419 T10418 nummod 7,Figure
R2994 T10420 T10418 punct ),Figure
R2995 T10421 T10397 punct .,revealed