Id |
Subject |
Object |
Predicate |
Lexical cue |
T2899 |
0-2 |
IN |
denotes |
To |
T2900 |
20-24 |
VBN |
denotes |
been |
T2901 |
3-7 |
NN |
denotes |
date |
T2902 |
7-9 |
, |
denotes |
, |
T2903 |
9-14 |
EX |
denotes |
there |
T2904 |
15-19 |
VBP |
denotes |
have |
T2905 |
25-27 |
DT |
denotes |
no |
T2906 |
37-46 |
NNS |
denotes |
mutations |
T2907 |
28-36 |
JJ |
denotes |
specific |
T2908 |
47-52 |
VBN |
denotes |
found |
T2909 |
53-55 |
TO |
denotes |
to |
T2910 |
56-58 |
VB |
denotes |
be |
T2911 |
59-69 |
JJ |
denotes |
associated |
T2912 |
70-74 |
IN |
denotes |
with |
T2913 |
75-87 |
JJ |
denotes |
nonsyndromic |
T2914 |
102-109 |
NNS |
denotes |
defects |
T2915 |
88-101 |
JJ |
denotes |
diaphragmatic |
T2916 |
110-113 |
CC |
denotes |
and |
T2917 |
114-123 |
JJ |
denotes |
pulmonary |
T2918 |
124-134 |
NN |
denotes |
hypoplasia |
T2919 |
135-137 |
IN |
denotes |
in |
T2920 |
138-144 |
NNS |
denotes |
humans |
T2921 |
144-145 |
. |
denotes |
. |
T2922 |
145-292 |
sentence |
denotes |
The heritability of these defects is unclear, as the high morbidity and mortality limit the collection of multigenerational families for analysis. |
T2923 |
146-149 |
DT |
denotes |
The |
T2924 |
150-162 |
NN |
denotes |
heritability |
T2925 |
180-182 |
VBZ |
denotes |
is |
T2926 |
163-165 |
IN |
denotes |
of |
T2927 |
166-171 |
DT |
denotes |
these |
T2928 |
172-179 |
NNS |
denotes |
defects |
T2929 |
183-190 |
JJ |
denotes |
unclear |
T2930 |
190-192 |
, |
denotes |
, |
T2931 |
192-194 |
IN |
denotes |
as |
T2932 |
228-233 |
VBP |
denotes |
limit |
T2933 |
195-198 |
DT |
denotes |
the |
T2934 |
204-213 |
NN |
denotes |
morbidity |
T2935 |
199-203 |
JJ |
denotes |
high |
T2936 |
214-217 |
CC |
denotes |
and |
T2937 |
218-227 |
NN |
denotes |
mortality |
T2938 |
234-237 |
DT |
denotes |
the |
T2939 |
238-248 |
NN |
denotes |
collection |
T2940 |
249-251 |
IN |
denotes |
of |
T2941 |
252-269 |
JJ |
denotes |
multigenerational |
T2942 |
270-278 |
NNS |
denotes |
families |
T2943 |
279-282 |
IN |
denotes |
for |
T2944 |
283-291 |
NN |
denotes |
analysis |
T2945 |
291-292 |
. |
denotes |
. |
T2946 |
292-481 |
sentence |
denotes |
The genetic etiologies are likely to be complex and probably arise from different mutations in various parts of the molecular developmental pathways required for diaphragmatic development. |
T2947 |
293-296 |
DT |
denotes |
The |
T2948 |
305-315 |
NNS |
denotes |
etiologies |
T2949 |
297-304 |
JJ |
denotes |
genetic |
T2950 |
316-319 |
VBP |
denotes |
are |
T2951 |
320-326 |
JJ |
denotes |
likely |
T2952 |
327-329 |
TO |
denotes |
to |
T2953 |
330-332 |
VB |
denotes |
be |
T2954 |
333-340 |
JJ |
denotes |
complex |
T2955 |
341-344 |
CC |
denotes |
and |
T2956 |
345-353 |
RB |
denotes |
probably |
T2957 |
354-359 |
VBP |
denotes |
arise |
T2958 |
360-364 |
IN |
denotes |
from |
T2959 |
365-374 |
JJ |
denotes |
different |
T2960 |
375-384 |
NNS |
denotes |
mutations |
T2961 |
385-387 |
IN |
denotes |
in |
T2962 |
388-395 |
JJ |
denotes |
various |
T2963 |
396-401 |
NNS |
denotes |
parts |
T2964 |
402-404 |
IN |
denotes |
of |
T2965 |
405-408 |
DT |
denotes |
the |
T2966 |
433-441 |
NNS |
denotes |
pathways |
T2967 |
409-418 |
JJ |
denotes |
molecular |
T2968 |
419-432 |
JJ |
denotes |
developmental |
T2969 |
442-450 |
VBN |
denotes |
required |
T2970 |
451-454 |
IN |
denotes |
for |
T2971 |
455-468 |
JJ |
denotes |
diaphragmatic |
T2972 |
469-480 |
NN |
denotes |
development |
T2973 |
480-481 |
. |
denotes |
. |
T2974 |
481-600 |
sentence |
denotes |
Indeed, there are numerous reports implicating different chromosomal abnormalities in the pathogenesis of CDH [12,13]. |
T2975 |
482-488 |
RB |
denotes |
Indeed |
T2976 |
496-499 |
VBP |
denotes |
are |
T2977 |
488-490 |
, |
denotes |
, |
T2978 |
490-495 |
EX |
denotes |
there |
T2979 |
500-508 |
JJ |
denotes |
numerous |
T2980 |
509-516 |
NNS |
denotes |
reports |
T2981 |
517-528 |
VBG |
denotes |
implicating |
T2982 |
529-538 |
JJ |
denotes |
different |
T2983 |
551-564 |
NNS |
denotes |
abnormalities |
T2984 |
539-550 |
JJ |
denotes |
chromosomal |
T2985 |
565-567 |
IN |
denotes |
in |
T2986 |
568-571 |
DT |
denotes |
the |
T2987 |
572-584 |
NN |
denotes |
pathogenesis |
T2988 |
585-587 |
IN |
denotes |
of |
T2989 |
588-591 |
NN |
denotes |
CDH |
T2990 |
592-593 |
-LRB- |
denotes |
[ |
T2991 |
596-598 |
CD |
denotes |
13 |
T2992 |
593-595 |
CD |
denotes |
12 |
T2993 |
595-596 |
, |
denotes |
, |
T2994 |
598-599 |
-RRB- |
denotes |
] |
T2995 |
599-600 |
. |
denotes |
. |
T2996 |
600-869 |
sentence |
denotes |
Given the difficulty of studying lethal developmental abnormalities in humans, it is of great potential utility to develop animal models of human birth defects, as the specific genetic abnormalities found in animal models can then be investigated in human populations. |
T2997 |
601-606 |
VBN |
denotes |
Given |
T2998 |
683-685 |
VBZ |
denotes |
is |
T2999 |
607-610 |
DT |
denotes |
the |
T3000 |
611-621 |
NN |
denotes |
difficulty |
T3001 |
622-624 |
IN |
denotes |
of |
T3002 |
625-633 |
VBG |
denotes |
studying |
T3003 |
634-640 |
JJ |
denotes |
lethal |
T3004 |
655-668 |
NNS |
denotes |
abnormalities |
T3005 |
641-654 |
JJ |
denotes |
developmental |
T3006 |
669-671 |
IN |
denotes |
in |
T3007 |
672-678 |
NNS |
denotes |
humans |
T3008 |
678-680 |
, |
denotes |
, |
T3009 |
680-682 |
PRP |
denotes |
it |
T3010 |
686-688 |
IN |
denotes |
of |
T3011 |
689-694 |
JJ |
denotes |
great |
T3012 |
705-712 |
NN |
denotes |
utility |
T3013 |
695-704 |
JJ |
denotes |
potential |
T3014 |
713-715 |
TO |
denotes |
to |
T3015 |
716-723 |
VB |
denotes |
develop |
T3016 |
724-730 |
NN |
denotes |
animal |
T3017 |
731-737 |
NNS |
denotes |
models |
T3018 |
738-740 |
IN |
denotes |
of |
T3019 |
741-746 |
JJ |
denotes |
human |
T3020 |
753-760 |
NNS |
denotes |
defects |
T3021 |
747-752 |
NN |
denotes |
birth |
T3022 |
760-762 |
, |
denotes |
, |
T3023 |
762-764 |
IN |
denotes |
as |
T3024 |
835-847 |
VBN |
denotes |
investigated |
T3025 |
765-768 |
DT |
denotes |
the |
T3026 |
786-799 |
NNS |
denotes |
abnormalities |
T3027 |
769-777 |
JJ |
denotes |
specific |
T3028 |
778-785 |
JJ |
denotes |
genetic |
T3029 |
800-805 |
VBN |
denotes |
found |
T3030 |
806-808 |
IN |
denotes |
in |
T3031 |
809-815 |
NN |
denotes |
animal |
T3032 |
816-822 |
NNS |
denotes |
models |
T3033 |
823-826 |
MD |
denotes |
can |
T3034 |
827-831 |
RB |
denotes |
then |
T3035 |
832-834 |
VB |
denotes |
be |
T3036 |
848-850 |
IN |
denotes |
in |
T3037 |
851-856 |
JJ |
denotes |
human |
T3038 |
857-868 |
NNS |
denotes |
populations |
T3039 |
868-869 |
. |
denotes |
. |
R538 |
T2899 |
T2900 |
prep |
To,been |
R539 |
T2901 |
T2899 |
pobj |
date,To |
R540 |
T2902 |
T2900 |
punct |
", ",been |
R541 |
T2903 |
T2900 |
expl |
there,been |
R542 |
T2904 |
T2900 |
aux |
have,been |
R543 |
T2905 |
T2906 |
det |
no,mutations |
R544 |
T2906 |
T2900 |
attr |
mutations,been |
R545 |
T2907 |
T2906 |
amod |
specific,mutations |
R546 |
T2908 |
T2906 |
acl |
found,mutations |
R547 |
T3015 |
T2998 |
xcomp |
develop,is |
R548 |
T3016 |
T3017 |
compound |
animal,models |
R549 |
T3017 |
T3015 |
dobj |
models,develop |
R550 |
T3018 |
T3017 |
prep |
of,models |
R551 |
T3019 |
T3020 |
amod |
human,defects |
R552 |
T3020 |
T3018 |
pobj |
defects,of |
R553 |
T3021 |
T3020 |
compound |
birth,defects |
R554 |
T3022 |
T3015 |
punct |
", ",develop |
R555 |
T3023 |
T3024 |
mark |
as,investigated |
R556 |
T3024 |
T3015 |
advcl |
investigated,develop |
R557 |
T3025 |
T3026 |
det |
the,abnormalities |
R558 |
T3026 |
T3024 |
nsubjpass |
abnormalities,investigated |
R559 |
T2909 |
T2910 |
aux |
to,be |
R560 |
T3027 |
T3026 |
amod |
specific,abnormalities |
R561 |
T2910 |
T2908 |
xcomp |
be,found |
R562 |
T3028 |
T3026 |
amod |
genetic,abnormalities |
R563 |
T2911 |
T2910 |
acomp |
associated,be |
R564 |
T2912 |
T2911 |
prep |
with,associated |
R565 |
T3029 |
T3026 |
acl |
found,abnormalities |
R566 |
T2913 |
T2914 |
amod |
nonsyndromic,defects |
R567 |
T2914 |
T2912 |
pobj |
defects,with |
R568 |
T2915 |
T2914 |
amod |
diaphragmatic,defects |
R569 |
T3030 |
T3029 |
prep |
in,found |
R570 |
T2916 |
T2914 |
cc |
and,defects |
R571 |
T2917 |
T2918 |
amod |
pulmonary,hypoplasia |
R572 |
T3031 |
T3032 |
compound |
animal,models |
R573 |
T2918 |
T2914 |
conj |
hypoplasia,defects |
R574 |
T2919 |
T2910 |
prep |
in,be |
R575 |
T2920 |
T2919 |
pobj |
humans,in |
R576 |
T3032 |
T3030 |
pobj |
models,in |
R577 |
T2921 |
T2900 |
punct |
.,been |
R578 |
T3033 |
T3024 |
aux |
can,investigated |
R579 |
T2923 |
T2924 |
det |
The,heritability |
R580 |
T2924 |
T2925 |
nsubj |
heritability,is |
R581 |
T3034 |
T3024 |
advmod |
then,investigated |
R582 |
T2926 |
T2924 |
prep |
of,heritability |
R583 |
T2927 |
T2928 |
det |
these,defects |
R584 |
T3035 |
T3024 |
auxpass |
be,investigated |
R585 |
T2928 |
T2926 |
pobj |
defects,of |
R586 |
T2929 |
T2925 |
acomp |
unclear,is |
R587 |
T3036 |
T3024 |
prep |
in,investigated |
R588 |
T3037 |
T3038 |
amod |
human,populations |
R589 |
T2930 |
T2925 |
punct |
", ",is |
R590 |
T2931 |
T2932 |
mark |
as,limit |
R591 |
T3038 |
T3036 |
pobj |
populations,in |
R592 |
T2932 |
T2925 |
advcl |
limit,is |
R593 |
T2933 |
T2934 |
det |
the,morbidity |
R594 |
T3039 |
T2998 |
punct |
.,is |
R595 |
T2934 |
T2932 |
nsubj |
morbidity,limit |
R596 |
T2935 |
T2934 |
amod |
high,morbidity |
R597 |
T2936 |
T2934 |
cc |
and,morbidity |
R599 |
T2937 |
T2934 |
conj |
mortality,morbidity |
R600 |
T2938 |
T2939 |
det |
the,collection |
R601 |
T2939 |
T2932 |
dobj |
collection,limit |
R602 |
T2940 |
T2939 |
prep |
of,collection |
R604 |
T2941 |
T2942 |
amod |
multigenerational,families |
R605 |
T2942 |
T2940 |
pobj |
families,of |
R606 |
T2943 |
T2939 |
prep |
for,collection |
R607 |
T2944 |
T2943 |
pobj |
analysis,for |
R608 |
T2945 |
T2925 |
punct |
.,is |
R610 |
T2947 |
T2948 |
det |
The,etiologies |
R611 |
T2948 |
T2950 |
nsubj |
etiologies,are |
R612 |
T2949 |
T2948 |
amod |
genetic,etiologies |
R614 |
T2951 |
T2950 |
acomp |
likely,are |
R615 |
T2952 |
T2953 |
aux |
to,be |
R617 |
T2953 |
T2951 |
xcomp |
be,likely |
R618 |
T2954 |
T2953 |
acomp |
complex,be |
R620 |
T2955 |
T2950 |
cc |
and,are |
R621 |
T2956 |
T2957 |
advmod |
probably,arise |
R622 |
T2957 |
T2950 |
conj |
arise,are |
R624 |
T2958 |
T2957 |
prep |
from,arise |
R625 |
T2959 |
T2960 |
amod |
different,mutations |
R626 |
T2960 |
T2958 |
pobj |
mutations,from |
R628 |
T2961 |
T2957 |
prep |
in,arise |
R629 |
T2962 |
T2963 |
amod |
various,parts |
R630 |
T2963 |
T2961 |
pobj |
parts,in |
R631 |
T2964 |
T2963 |
prep |
of,parts |
R633 |
T2965 |
T2966 |
det |
the,pathways |
R634 |
T2966 |
T2964 |
pobj |
pathways,of |
R636 |
T2967 |
T2966 |
amod |
molecular,pathways |
R637 |
T2968 |
T2966 |
amod |
developmental,pathways |
R638 |
T2969 |
T2966 |
acl |
required,pathways |
R640 |
T2970 |
T2969 |
prep |
for,required |
R641 |
T2971 |
T2972 |
amod |
diaphragmatic,development |
R642 |
T2972 |
T2970 |
pobj |
development,for |
R644 |
T2973 |
T2950 |
punct |
.,are |
R646 |
T2975 |
T2976 |
advmod |
Indeed,are |
R648 |
T2977 |
T2976 |
punct |
", ",are |
R649 |
T2978 |
T2976 |
expl |
there,are |
R650 |
T2979 |
T2980 |
amod |
numerous,reports |
R652 |
T2980 |
T2976 |
attr |
reports,are |
R653 |
T2981 |
T2980 |
acl |
implicating,reports |
R654 |
T2982 |
T2983 |
amod |
different,abnormalities |
R655 |
T2983 |
T2981 |
dobj |
abnormalities,implicating |
R657 |
T2984 |
T2983 |
amod |
chromosomal,abnormalities |
R658 |
T2985 |
T2981 |
prep |
in,implicating |
R659 |
T2986 |
T2987 |
det |
the,pathogenesis |
R660 |
T2987 |
T2985 |
pobj |
pathogenesis,in |
R661 |
T2988 |
T2987 |
prep |
of,pathogenesis |
R663 |
T2989 |
T2988 |
pobj |
CDH,of |
R664 |
T2990 |
T2991 |
punct |
[,13 |
R665 |
T2991 |
T2976 |
parataxis |
13,are |
R667 |
T2992 |
T2991 |
nummod |
12,13 |
R668 |
T2993 |
T2991 |
punct |
",",13 |
R669 |
T2994 |
T2991 |
punct |
],13 |
R671 |
T2995 |
T2976 |
punct |
.,are |
R673 |
T2997 |
T2998 |
prep |
Given,is |
R674 |
T2999 |
T3000 |
det |
the,difficulty |
R676 |
T3000 |
T2997 |
pobj |
difficulty,Given |
R677 |
T3001 |
T3000 |
prep |
of,difficulty |
R678 |
T3002 |
T3001 |
pcomp |
studying,of |
R680 |
T3003 |
T3004 |
amod |
lethal,abnormalities |
R681 |
T3004 |
T3002 |
dobj |
abnormalities,studying |
R683 |
T3005 |
T3004 |
amod |
developmental,abnormalities |
R684 |
T3006 |
T3002 |
prep |
in,studying |
R685 |
T3007 |
T3006 |
pobj |
humans,in |
R687 |
T3008 |
T2998 |
punct |
", ",is |
R688 |
T3009 |
T2998 |
nsubj |
it,is |
R689 |
T3010 |
T2998 |
prep |
of,is |
R691 |
T3011 |
T3012 |
amod |
great,utility |
R692 |
T3012 |
T3010 |
pobj |
utility,of |
R694 |
T3013 |
T3012 |
amod |
potential,utility |
R695 |
T3014 |
T3015 |
aux |
to,develop |