PMC:1183529 / 1653-2437 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1183529","sourcedb":"PMC","sourceid":"1183529","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1183529","text":"enetic disorders such as cystic fibrosis, yet the underlying causes of these defects are unknown. Most babies born with diaphragmatic defects have very small lungs, and many die in the newborn period with severe breathing difficulties. It is unknown whether the small lungs occur because these children have a diaphragmatic defect, or whether some patients might have a genetic abnormality that affects the development of both the lung and the diaphragm simultaneously.\nIn a screen of fetal mice carrying chemically induced genetic mutations, the authors found that a mutation in the gene Fog2 (Friend of gata 2), causes abnormal diaphragm development and small lungs. The lungs have a primary developmental abnormality that includes the specific loss of one lung lobe. Based on this ","tracks":[]}