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PMC:1183529 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T897 28-37 UBERON:0001103 denotes Diaphragm
T898 28-37 _FRAGMENT denotes Diaphragm
T899 47-58 GO:0060539 denotes Development
T900 42-46 UBERON:0002048 denotes Lung
T901 42-58 GO:0030324 denotes Lung Development
T902 62-66 NCBITaxon:10088 denotes Mice
T903 71-77 NCBITaxon:9606 denotes Humans
T904 148-161 UBERON:0001103 denotes diaphragmatic
T905 190-203 UBERON:0001103 denotes diaphragmatic
T906 379-386 UBERON:0000922 denotes embryos
T907 400-404 NCBITaxon:10088 denotes mice
T908 418-439 CHEBI:23995 denotes N-ethyl-N-nitrosourea
T909 478-487 UBERON:0002048 denotes pulmonary
T910 512-525 UBERON:0001103 denotes diaphragmatic
T911 512-537 GO:0060539 denotes diaphragmatic development
T912 539-543 PR:000017653 denotes Fog2
T913 545-550 PR:000017653 denotes Zfpm2
T914 602-623 CHEBI:23995 denotes N-ethyl-N-nitrosourea
T915 664-668 PR:000017653 denotes Fog2
T916 696-702 GO:0008380 denotes splice
T917 741-751 SO:0000673 denotes transcript
T918 782-787 NCBITaxon:9606 denotes Human
T919 807-820 UBERON:0001103 denotes diaphragmatic
T920 832-841 UBERON:0002048 denotes pulmonary
T921 885-889 PR:000017653 denotes FOG2
T922 952-972 SO:0001587 denotes premature stop codon
T923 988-992 GO:0016265 denotes died
T924 1013-1017 UBERON:0000104 denotes life
T925 1048-1057 UBERON:0002048 denotes pulmonary
T926 1100-1109 UBERON:0001103 denotes diaphragm
T927 1171-1175 PR:000017653 denotes Fog2
T928 1199-1208 UBERON:0001103 denotes diaphragm
T929 1213-1217 UBERON:0002048 denotes lung
T930 1213-1229 GO:0030324 denotes lung development
T931 1280-1284 PR:000017653 denotes FOG2
T932 1298-1302 SO:0000704 denotes gene
T933 1350-1355 NCBITaxon:9606 denotes human
T934 1367-1380 UBERON:0001103 denotes diaphragmatic
T935 1412-1421 UBERON:0002048 denotes pulmonary
T936 1412-1433 GO:0030324 denotes pulmonary development
T937 1489-1502 UBERON:0001103 denotes diaphragmatic
T938 1532-1541 UBERON:0002048 denotes pulmonary
T939 1532-1555 GO:0030324 denotes pulmonary developmental
T2431 3038-3051 UBERON:0001103 denotes diaphragmatic
T2432 3096-3101 GO:0007567 denotes birth
T2433 3184-3197 UBERON:0001103 denotes diaphragmatic
T2434 3293-3306 UBERON:0001103 denotes diaphragmatic
T2435 3328-3333 GO:0007567 denotes birth
T2436 3335-3348 UBERON:0001103 denotes diaphragmatic
T2437 3361-3374 UBERON:0001103 denotes diaphragmatic
T2438 3472-3480 UBERON:0001062 denotes anatomic
T2439 3584-3590 GO:0016265 denotes mortem
T2440 3605-3614 UBERON:0002048 denotes Pulmonary
T2441 3648-3661 UBERON:0001103 denotes diaphragmatic
T2442 3765-3778 UBERON:0001103 denotes diaphragmatic
T2443 3791-3800 UBERON:0002048 denotes pulmonary
T2444 3878-3887 UBERON:0002048 denotes pulmonary
T2445 4123-4129 GO:0016265 denotes deaths
T2446 4139-4144 GO:0007567 denotes birth
T2447 4240-4251 UBERON:0001004 denotes respiratory
T2448 4263-4268 GO:0007567 denotes birth
T2449 4388-4392 UBERON:0002048 denotes lung
T2450 4425-4436 GO:0015671 denotes oxygenation
T2451 4695-4706 UBERON:0001004 denotes respiratory
T2452 4722-4731 GO:0050890 denotes cognitive
T2453 4736-4746 GO:0050905 denotes neuromotor
T2454 4761-4768 GO:0007605 denotes hearing
T2455 4990-5003 UBERON:0001103 denotes diaphragmatic
T2456 5016-5025 UBERON:0002048 denotes pulmonary
T2457 5040-5046 NCBITaxon:9606 denotes humans
T2458 5199-5206 SO:0000704 denotes genetic
T2459 5357-5370 UBERON:0001103 denotes diaphragmatic
T2460 5357-5382 GO:0060539 denotes diaphragmatic development
T2461 5574-5580 NCBITaxon:9606 denotes humans
T2462 5626-5632 NCBITaxon:33208 denotes animal
T2463 5643-5648 NCBITaxon:9606 denotes human
T2464 5649-5654 GO:0007567 denotes birth
T2465 5680-5687 SO:0000704 denotes genetic
T2466 5711-5717 NCBITaxon:33208 denotes animal
T2467 5753-5758 NCBITaxon:9606 denotes human
T2468 5784-5788 NCBITaxon:10088 denotes mice
T2469 5815-5822 CHEBI:25435 denotes mutagen
T2470 5823-5844 CHEBI:23995 denotes N-ethyl-N-nitrosourea
T2471 5846-5849 CHEBI:23995 denotes ENU
T2472 5908-5924 UBERON:0012101 denotes perinatal period
T2473 5912-5917 GO:0007567 denotes natal
T2474 5973-5977 NCBITaxon:10088 denotes mice
T2475 6032-6041 UBERON:0002048 denotes pulmonary
T2476 6066-6079 UBERON:0001103 denotes diaphragmatic
T2477 6066-6079 _FRAGMENT denotes diaphragmatic
T2478 6092-6103 GO:0060539 denotes development
T2479 6084-6091 UBERON:0000948 denotes cardiac
T2480 6084-6103 GO:0007507 denotes cardiac development
T2481 6144-6148 PR:000017653 denotes Fog2
T2482 6150-6155 PR:000017653 denotes Zfpm2
T2483 6224-6230 GO:0008380 denotes splice
T2484 6269-6279 SO:0000673 denotes transcript
T2485 6352-6363 SO:0000858 denotes orthologous
T2486 6364-6368 SO:0000704 denotes gene
T2487 6372-6378 NCBITaxon:9606 denotes humans
T2488 6475-6479 PR:000017653 denotes FOG2
T2489 6497-6501 GO:0016265 denotes died
T2490 6505-6510 GO:0007567 denotes birth
T2491 6518-6531 UBERON:0001103 denotes diaphragmatic
T2492 6550-6559 UBERON:0002048 denotes pulmonary
T2493 6649-6654 NCBITaxon:9606 denotes human
T2494 6717-6726 UBERON:0002048 denotes pulmonary
T5066 6835-6839 UBERON:0002048 denotes lung
T5067 6852-6856 PR:000017653 denotes Fog2
T5068 6897-6900 CHEBI:23995 denotes ENU
T5069 6913-6917 NCBITaxon:10088 denotes mice
T5070 6921-6930 UBERON:0000922 denotes embryonic
T5071 7004-7008 NCBITaxon:10088 denotes mice
T5072 7036-7043 UBERON:0000922 denotes embryos
T5073 7082-7091 UBERON:0002048 denotes pulmonary
T5074 7114-7123 UBERON:0001103 denotes diaphragm
T5075 7162-7166 UBERON:0002048 denotes lung
T5076 7238-7247 SO:0001024 denotes haplotype
T5077 7410-7414 NCBITaxon:10088 denotes mice
T5078 7754-7762 SO:0000357 denotes flanking
T5079 7832-7841 UBERON:0002048 denotes pulmonary
T5080 7869-7878 UBERON:0001103 denotes diaphragm
T5081 7880-7889 UBERON:0002048 denotes Pulmonary
T5082 7928-7932 NCBITaxon:10088 denotes mice
T5083 7950-7955 GO:0007567 denotes birth
T5084 8002-8006 NCBITaxon:10088 denotes mice
T5085 8032-8036 UBERON:0000104 denotes life
T5086 8084-8088 UBERON:0002048 denotes lung
T5087 8136-8140 NCBITaxon:10088 denotes mice
T5088 8161-8165 UBERON:0002048 denotes lung
T5089 8218-8222 UBERON:0002048 denotes lung
T5090 8265-8270 UBERON:0002048 denotes lungs
T5091 8283-8287 NCBITaxon:10088 denotes mice
T5092 8314-8318 UBERON:0009912 denotes lobe
T5093 8391-8395 UBERON:0009912 denotes lobe
T5094 8409-8419 UBERON:0001103 denotes Diaphragms
T5095 8436-8440 NCBITaxon:10088 denotes mice
T5096 8508-8518 CL:0002372 denotes Myotubules
T5097 8591-8601 CL:0002372 denotes myotubules
T5098 8665-8675 UBERON:0000309 denotes body walls
T5099 8702-8715 CL:0000187 denotes muscle fibers
T5100 8723-8740 UBERON:0006670 denotes central tendonous
T5101 8763-8772 UBERON:0001103 denotes diaphragm
T5102 8774-8784 CL:0002372 denotes myotubules
T5103 8831-8844 UBERON:0002385 denotes muscle tissue
T5104 8884-8894 UBERON:0000309 denotes body walls
T5105 9389-9393 NCBITaxon:10088 denotes mice
T5106 9411-9416 GO:0007567 denotes birth
T5107 9541-9550 UBERON:0000922 denotes embryonic
T5108 9620-9627 UBERON:0000995 denotes uterine
T5109 9628-9634 GO:0016265 denotes demise
T5110 9701-9708 UBERON:0000922 denotes embryos
T5111 9760-9767 UBERON:0000995 denotes uterine
T5112 9768-9774 GO:0016265 denotes demise
T5113 9818-9824 UBERON:0000479 denotes tissue
T5114 9841-9848 UBERON:0000922 denotes embryos
T5115 9884-9890 GO:0016265 denotes demise
T5116 10062-10066 GO:0016265 denotes died
T5117 10136-10143 UBERON:0000922 denotes embryos
T5118 10167-10171 GO:0016265 denotes died
T5119 10194-10201 UBERON:0000922 denotes embryos
T5120 10260-10266 UBERON:0000922 denotes embryo
T5121 10279-10292 UBERON:0001103 denotes Diaphragmatic
T5122 10336-10340 NCBITaxon:10088 denotes mice
T5123 10360-10369 UBERON:0002048 denotes Pulmonary
T5125 10491-10498 UBERON:0000948 denotes cardiac
T5126 10522-10528 UBERON:0000948 denotes hearts
T5127 10551-10555 NCBITaxon:10088 denotes mice
T5128 10640-10660 UBERON:0002062 denotes endocardial cushions
T5129 10671-10677 UBERON:0004145 denotes outlet
T5130 10678-10693 UBERON:0002080 denotes right ventricle
T5131 10710-10732 UBERON:0002087 denotes atrioventricular canal
T5132 10738-10748 UBERON:0002349 denotes myocardium
T5133 10803-10816 UBERON:0004125 denotes compact layer
T5134 10865-10869 NCBITaxon:10088 denotes mice
T5135 10887-10892 GO:0007567 denotes birth
T5136 10902-10909 UBERON:0000948 denotes cardiac
T5137 10934-10956 UBERON:0002087 denotes atrioventricular-canal
T5138 10962-10980 UBERON:0002094 denotes ventricular septal
T5139 10990-11003 UBERON:0009149 denotes ostium primum
T5140 11004-11017 UBERON:0002085 denotes atrial septal
T5141 11040-11045 UBERON:0002081 denotes atria
T5142 11105-11112 UBERON:0000948 denotes cardiac
T5143 11145-11152 UBERON:0000948 denotes cardiac
T5144 11145-11164 GO:0007507 denotes cardiac development
T5145 11267-11282 SO:0000996 denotes predicted genes
T5146 11298-11303 SO:0000704 denotes genes
T5147 11315-11319 PR:000017653 denotes Fog2
T5148 11343-11347 PR:000017653 denotes Fog2
T5149 11353-11360 UBERON:0000948 denotes cardiac
T5150 11425-11429 NCBITaxon:10088 denotes mice
T5151 11441-11463 UBERON:0002087 denotes atrioventricular canal
T5152 11481-11491 UBERON:0002349 denotes myocardium
T5153 11504-11512 UBERON:0005985 denotes coronary
T5154 11513-11524 UBERON:0002049 denotes vasculature
T5155 11579-11583 PR:000017653 denotes Fog2
T5156 11600-11611 SO:0000673 denotes transcripts
T5157 11652-11659 UBERON:0000922 denotes embryos
T5158 11698-11708 SO:0000673 denotes transcript
T5159 11764-11766 SO:0000028 denotes bp
T5160 11803-11809 GO:0008380 denotes splice
T5161 11845-11849 SO:0000147 denotes exon
T5162 11874-11882 GO:0008380 denotes splicing
T5163 11926-11928 SO:0000028 denotes bp
T5164 11932-11940 SO:0000188 denotes intronic
T5165 11966-11976 SO:0000673 denotes transcript
T5166 11995-12005 SO:0000319 denotes stop codon
T5167 12095-12099 NCBITaxon:10088 denotes mice
T5168 12120-12124 PR:000017653 denotes Fog2
T5169 12135-12141 SO:0001023 denotes allele
T5170 12163-12167 SO:0000704 denotes gene
T5171 12204-12208 NCBITaxon:10088 denotes mice
T5172 12216-12225 UBERON:0000922 denotes embryonic
T5173 12304-12308 PR:000017653 denotes Fog2
T5174 12340-12344 NCBITaxon:10088 denotes mice
T5175 12377-12381 PR:000017653 denotes Fog2
T5176 12452-12462 SO:0000673 denotes transcript
T5177 12491-12497 GO:0008380 denotes splice
T5178 12491-12502 SO:0000162 denotes splice site
T7827 12938-12942 UBERON:0002048 denotes Lung
T7828 12938-12942 _FRAGMENT denotes Lung
T7829 12957-12968 GO:0030324 denotes Development
T7830 12947-12956 UBERON:0001103 denotes Diaphragm
T7831 12947-12968 GO:0060539 denotes Diaphragm Development
T7832 12976-12980 PR:000017653 denotes Fog2
T7833 12988-12993 NCBITaxon:10088 denotes Mouse
T7834 13045-13049 PR:000017653 denotes Fog2
T7835 13053-13062 UBERON:0002048 denotes pulmonary
T7836 13053-13062 _FRAGMENT denotes pulmonary
T7837 13081-13092 GO:0030324 denotes development
T7838 13067-13080 UBERON:0001103 denotes diaphragmatic
T7839 13067-13092 GO:0060539 denotes diaphragmatic development
T7840 13098-13107 UBERON:0002048 denotes pulmonary
T7841 13192-13196 UBERON:0009912 denotes lobe
T7842 13231-13235 UBERON:0009912 denotes lobe
T7843 13289-13302 UBERON:0001103 denotes diaphragmatic
T7844 13289-13314 GO:0060539 denotes diaphragmatic development
T7845 13360-13369 UBERON:0002048 denotes pulmonary
T7846 13467-13471 PR:000017653 denotes Fog2
T7847 13475-13484 GO:0010467 denotes expressed
T7848 13502-13522 UBERON:0004883 denotes pulmonary mesenchyme
T7849 13544-13567 GO:0001763 denotes branching morphogenesis
T7850 13581-13591 GO:0010467 denotes expression
T7851 13613-13627 UBERON:0001135 denotes smooth muscles
T7852 13631-13638 UBERON:0001005 denotes airways
T7853 13643-13652 UBERON:0002048 denotes pulmonary
T7854 13653-13660 UBERON:0000055 denotes vessels
T7855 13704-13709 UBERON:0002048 denotes lungs
T7856 13767-13780 UBERON:0001103 denotes diaphragmatic
T7857 13828-13837 UBERON:0002048 denotes pulmonary
T7858 13877-13890 UBERON:0001103 denotes diaphragmatic
T7859 13924-13929 UBERON:0002048 denotes lungs
T7860 13950-13954 PR:000017653 denotes Fog2
T7861 13959-13963 NCBITaxon:10088 denotes mice
T7862 14014-14027 UBERON:0001103 denotes diaphragmatic
T7863 14036-14040 PR:000017653 denotes Fog2
T7864 14045-14049 NCBITaxon:10088 denotes mice
T7865 14168-14173 UBERON:0002048 denotes Lungs
T7866 14196-14200 PR:000017653 denotes Fog2
T7867 14205-14212 UBERON:0000922 denotes embryos
T7868 14277-14281 UBERON:0009912 denotes lobe
T7869 14296-14300 PR:000017653 denotes Fog2
T7870 14305-14309 UBERON:0002048 denotes lung
T7871 14372-14376 UBERON:0009912 denotes lobe
T7872 14404-14409 UBERON:0002048 denotes lungs
T7873 14530-14539 UBERON:0002048 denotes pulmonary
T7874 14554-14558 PR:000017653 denotes Fog2
T7875 14566-14570 NCBITaxon:10088 denotes mice
T7876 15232-15237 UBERON:0009912 denotes lobes
T7877 15347-15352 UBERON:0009912 denotes lobes
T7878 15388-15392 PR:000017653 denotes Fog2
T7879 15428-15433 UBERON:0009912 denotes lobar
T7880 15463-15467 PR:000017653 denotes Fog2
T7881 15468-15478 GO:0010467 denotes expression
T7882 15503-15510 UBERON:0000922 denotes embryos
T7883 15538-15543 UBERON:0009912 denotes lobar
T7884 15579-15583 PR:000017653 denotes Fog2
T7885 15584-15594 GO:0010467 denotes expression
T7886 15630-15635 UBERON:0009912 denotes lobar
T7887 15642-15652 GO:0010467 denotes Expression
T7888 15670-15674 NCBITaxon:10088 denotes mice
T7889 15686-15690 PR:000033987 denotes lacZ
T7890 15691-15695 SO:0000704 denotes gene
T7891 15718-15722 PR:000017653 denotes Fog2
T7892 15770-15774 NCBITaxon:10088 denotes mice
T7893 15798-15803 UBERON:0002048 denotes lungs
T7894 15837-15841 PR:000017653 denotes Fog2
T7895 15842-15852 GO:0010467 denotes expression
T7896 15860-15870 UBERON:0003104 denotes mesenchyme
T7897 15922-15926 UBERON:0009912 denotes lobe
T7898 15946-15951 UBERON:0009912 denotes lobes
T7899 15984-15988 PR:000017653 denotes Fog2
T7900 15996-16000 NCBITaxon:10088 denotes mice
T7901 16023-16033 GO:0010467 denotes expression
T7902 16053-16073 UBERON:0004883 denotes pulmonary mesenchyme
T7903 16111-16124 GO:0097617 denotes hybridization
T7904 16128-16134 UBERON:0000479 denotes tissue
T7905 16419-16429 UBERON:0001103 denotes Diaphragms
T7906 16435-16439 PR:000017653 denotes Fog2
T7907 16444-16448 NCBITaxon:10088 denotes mice
T7908 16557-16566 UBERON:0001103 denotes diaphragm
T7909 16609-16631 CL:0000680 denotes muscle precursor cells
T7910 16647-16652 UBERON:0002101 denotes limbs
T7911 16662-16666 NCBITaxon:10088 denotes Mice
T7912 16683-16688 SO:0000704 denotes genes
T7913 16719-16726 GO:0065007 denotes control
T7914 16769-16779 UBERON:0001103 denotes diaphragms
T7915 16792-16802 CL:0000182 denotes Hepatocyte
T7916 16792-16816 PR:000008534 denotes Hepatocyte growth factor
T7917 16817-16831 PR:000008534 denotes Scatter factor
T7918 16833-16836 PR:000008534 denotes HGF
T7919 16933-16942 UBERON:0001103 denotes diaphragm
T7920 16967-16970 PR:000008534 denotes HGF
T7921 16974-16983 GO:0010467 denotes expressed
T7922 16995-17003 UBERON:0001062 denotes anatomic
T7923 17022-17026 NCBITaxon:10088 denotes mice
T7924 17047-17050 PR:000008534 denotes HGF
T7925 17060-17065 PR:000010335 denotes c-Met
T7926 17092-17114 UBERON:0009133 denotes pleuroperitoneal folds
T7927 17116-17120 UBERON:0009133 denotes PPFs
T7928 17147-17157 UBERON:0001103 denotes diaphragms
T7929 17167-17171 PR:000017653 denotes Fog2
T7930 17175-17184 GO:0010467 denotes expressed
T7931 17218-17227 UBERON:0001103 denotes diaphragm
T7932 17274-17283 UBERON:0001103 denotes diaphragm
T7933 17308-17312 PR:000012316 denotes Pax3
T7934 17317-17321 PR:000010875 denotes MyoD
T7935 17443-17447 UBERON:0009133 denotes PPFs
T7936 17451-17455 PR:000017653 denotes Fog2
T7937 17460-17464 NCBITaxon:10088 denotes mice
T7938 17500-17510 GO:0010467 denotes expression
T7939 17542-17552 GO:0010467 denotes expression
T7940 17556-17559 PR:000008534 denotes HGF
T7941 17616-17625 UBERON:0001103 denotes diaphragm
T7942 17650-17654 PR:000017653 denotes Fog2
T7943 17662-17666 NCBITaxon:10088 denotes mice
T7944 17699-17703 PR:000017653 denotes Fog2
T7945 17769-17772 PR:000008534 denotes HGF
T7946 17791-17800 UBERON:0001103 denotes diaphragm
T7947 17809-17819 GO:0065007 denotes regulation
T7948 17823-17826 PR:000008534 denotes HGF
T7949 17856-17877 CL:0000680 denotes muscle precursor cell
T7950 17873-17887 GO:0016477 denotes cell migration
T7951 17900-17903 UBERON:0009133 denotes PPF
T7952 17912-17921 UBERON:0001103 denotes diaphragm
T7953 17967-17971 NCBITaxon:10088 denotes mice
T9793 18221-18225 PR:000017653 denotes FOG2
T9794 18253-18262 UBERON:0001103 denotes Diaphragm
T9795 18267-18271 UBERON:0002048 denotes Lung
T9796 18286-18290 PR:000017653 denotes FOG2
T9797 18334-18340 UBERON:0000479 denotes tissue
T9798 18381-18389 UBERON:0001062 denotes anatomic
T9799 18403-18416 UBERON:0001103 denotes diaphragmatic
T9800 18637-18650 UBERON:0001103 denotes diaphragmatic
T9801 18677-18690 UBERON:0001103 denotes diaphragmatic
T9802 18839-18848 UBERON:0002048 denotes Pulmonary
T9803 18879-18883 UBERON:0002048 denotes lung
T9804 18913-18921 UBERON:0003215 denotes alveolar
T9805 19112-19116 PR:000017653 denotes FOG2
T9806 19201-19212 UBERON:0001004 denotes respiratory
T9807 19224-19229 GO:0007567 denotes birth
T9808 19234-19238 GO:0016265 denotes died
T9809 19271-19277 GO:0016265 denotes mortem
T9810 19307-19311 UBERON:0002048 denotes lung
T9811 19332-19337 UBERON:0000160 denotes bowel
T9812 19345-19350 UBERON:0001443 denotes chest
T9813 19447-19456 UBERON:0002048 denotes pulmonary
T9814 19478-19482 UBERON:0002048 denotes lung
T9815 19582-19591 UBERON:0002168 denotes left lung
T9816 19597-19601 UBERON:0002048 denotes lung
T9817 19725-19733 UBERON:0003215 denotes alveolar
T9818 19791-19795 UBERON:0002048 denotes lung
T9819 19835-19848 UBERON:0001103 denotes diaphragmatic
T9820 19922-19933 UBERON:0000211 denotes ligamentous
T9821 19951-19964 UBERON:0001103 denotes diaphragmatic
T9822 19988-20000 _FRAGMENT denotes left lobe of
T9823 20005-20010 UBERON:0001115 denotes liver
T9824 20042-20047 UBERON:0002107 denotes liver
T9825 20088-20097 UBERON:0001103 denotes diaphragm
T9826 20213-20218 UBERON:0000948 denotes heart
T9827 20275-20280 UBERON:0003978 denotes valve
T9828 20362-20366 SO:0000147 denotes exon
T9829 20422-20432 SO:0000319 denotes stop codon
T9830 20520-20527 SO:0000417 denotes domains
T9831 20612-20618 UBERON:0007023 denotes adults
T9832 20887-20891 PR:000017653 denotes FOG2
T12680 21289-21302 UBERON:0001103 denotes diaphragmatic
T12681 21411-21427 UBERON:0012101 denotes perinatal period
T12682 21415-21420 GO:0007567 denotes natal
T12683 21454-21467 UBERON:0001103 denotes diaphragmatic
T12684 21800-21809 UBERON:0001103 denotes diaphragm
T12685 21882-21887 GO:0007567 denotes natal
T12686 21906-21911 GO:0007567 denotes natal
T12687 21912-21917 UBERON:0001443 denotes chest
T12688 21945-21958 UBERON:0001103 denotes diaphragmatic
T12689 22346-22355 UBERON:0000916 denotes abdominal
T12690 22386-22395 UBERON:0002048 denotes pulmonary
T12691 22411-22422 UBERON:0001004 denotes respiratory
T12692 22527-22536 UBERON:0001103 denotes diaphragm
T12693 22560-22565 NCBITaxon:9606 denotes Human
T12694 22566-22570 PR:000017653 denotes FOG2
T12695 22638-22647 UBERON:0001103 denotes diaphragm
T12696 22829-22833 PR:000017653 denotes FOG2
T12697 22919-22923 PR:000017653 denotes FOG2
T12698 22935-22939 GO:0016265 denotes died
T12699 23019-23023 SO:0000704 denotes gene
T12700 23174-23178 PR:000017653 denotes FOG2
T12701 23235-23244 UBERON:0002048 denotes pulmonary
T12702 23249-23262 UBERON:0001103 denotes diaphragmatic
T12703 23291-23296 NCBITaxon:10088 denotes mouse
T12704 23301-23306 NCBITaxon:9606 denotes human
T12705 23341-23345 PR:000017653 denotes FOG2
T12706 23379-23384 NCBITaxon:9606 denotes human
T12707 23399-23412 UBERON:0001103 denotes diaphragmatic
T12708 23417-23426 UBERON:0002048 denotes pulmonary
T12709 23470-23474 NCBITaxon:10088 denotes mice
T12710 23511-23515 PR:000017653 denotes Fog2
T12711 23614-23618 SO:0000704 denotes gene
T12712 23679-23685 NCBITaxon:9606 denotes humans
T12713 23691-23695 NCBITaxon:10088 denotes mice
T12714 23724-23728 PR:000017653 denotes Fog2
T12715 23729-23742 UBERON:0001103 denotes diaphragmatic
T12716 23894-23903 UBERON:0001103 denotes diaphragm
T12717 23929-23941 UBERON:0004290 denotes dermomyotome
T12718 23945-23953 UBERON:0005434 denotes cervical
T12719 23954-23961 UBERON:0002329 denotes somites
T12720 23991-24000 UBERON:0001103 denotes diaphragm
T12721 24020-24023 UBERON:0009133 denotes PPF
T12722 24040-24046 UBERON:0000479 denotes tissue
T12723 24085-24094 UBERON:0000309 denotes body wall
T12724 24102-24122 UBERON:0003283 denotes esophageal mesentery
T12725 24152-24170 UBERON:0004161 denotes septum transversum
T12726 24205-24208 UBERON:0009133 denotes PPF
T12727 24228-24239 GO:0008283 denotes proliferate
T12728 24297-24303 UBERON:0002228 denotes costal
T12729 24305-24312 UBERON:0000975 denotes sternal
T12730 24313-24319 UBERON:0002228 denotes costal
T12731 24325-24331 UBERON:0000978 denotes crural
T12732 24358-24367 UBERON:0001103 denotes diaphragm
T12733 24387-24390 UBERON:0009133 denotes PPF
T12734 24438-24450 _FRAGMENT denotes formation of
T12735 24455-24464 GO:0060539 denotes diaphragm
T12736 24455-24464 UBERON:0001103 denotes diaphragm
T12737 24494-24498 PR:000017653 denotes Fog2
T12738 24539-24542 PR:000008534 denotes HGF
T12739 24543-24553 GO:0010467 denotes expression
T12740 24582-24604 CL:0000680 denotes muscle precursor cells
T12741 24633-24642 UBERON:0001103 denotes diaphragm
T12742 24726-24730 PR:000017653 denotes Fog2
T12743 24738-24747 UBERON:0001103 denotes diaphragm
T12744 24758-24762 PR:000012316 denotes Pax3
T12745 24767-24771 PR:000010875 denotes MyoD
T12746 24772-24782 GO:0010467 denotes expression
T12747 24802-24805 UBERON:0009133 denotes PPF
T12748 24868-24889 CL:0000680 denotes muscle precursor cell
T12749 24885-24899 GO:0016477 denotes cell migration
T12750 24885-24889 _FRAGMENT denotes cell
T12751 24904-24919 GO:0030154 denotes differentiation
T12752 24958-24961 UBERON:0009133 denotes PPF
T12753 24987-25008 CL:0000680 denotes muscle precursor cell
T12754 25004-25018 GO:0016477 denotes cell migration
T12755 25031-25034 UBERON:0009133 denotes PPF
T12756 25054-25063 UBERON:0001103 denotes diaphragm
T12757 25065-25069 PR:000017653 denotes Fog2
T12758 25113-25120 PR:000007857 denotes Gatas 1
T12759 25113-25118 _FRAGMENT denotes Gatas
T12760 25121-25122 PR:000007861 denotes 6
T12761 25171-25179 PR:000011405 denotes CoupTFII
T12762 25208-25212 PR:000017653 denotes Fog2
T12763 25213-25218 PR:000007859 denotes Gata4
T12764 25254-25261 UBERON:0000948 denotes cardiac
T12765 25254-25261 _FRAGMENT denotes cardiac
T12766 25274-25285 GO:0007507 denotes development
T12767 25266-25273 UBERON:0000991 denotes gonadal
T12768 25266-25285 GO:0008406 denotes gonadal development
T12769 25318-25322 UBERON:0002048 denotes lung
T12770 25327-25336 UBERON:0001103 denotes diaphragm
T12771 25383-25392 UBERON:0002048 denotes pulmonary
T12772 25466-25475 UBERON:0001103 denotes diaphragm
T12773 25484-25493 UBERON:0002048 denotes Pulmonary
T12774 25533-25546 UBERON:0001103 denotes diaphragmatic
T12775 25547-25554 UBERON:0001062 denotes anatomy
T12776 25639-25652 UBERON:0001103 denotes diaphragmatic
T12777 25707-25720 UBERON:0001884 denotes phrenic nerve
T12778 25830-25834 NCBITaxon:9940 denotes lamb
T12779 25882-25891 UBERON:0002048 denotes pulmonary
T12780 25882-25905 GO:0030324 denotes pulmonary developmental
T12781 25958-25971 UBERON:0001103 denotes diaphragmatic
T12782 26020-26031 CHEBI:50905 denotes teratogenic
T12783 26159-26164 UBERON:0009912 denotes lobar
T12784 26295-26304 UBERON:0002048 denotes pulmonary
T12785 26334-26338 NCBITaxon:10088 denotes mice
T12786 26361-26365 PR:000017653 denotes Fog2
T12787 26407-26411 UBERON:0002048 denotes lung
T12788 26407-26423 GO:0030324 denotes lung development
T12789 26471-26475 UBERON:0009912 denotes lobe
T12790 26513-26517 UBERON:0009912 denotes lobe
T12791 26532-26537 UBERON:0009912 denotes lobar
T12792 26570-26574 PR:000017653 denotes Fog2
T12793 26575-26585 GO:0010467 denotes expression
T12794 26607-26612 UBERON:0009912 denotes lobar
T12795 26628-26632 PR:000017653 denotes Fog2
T12796 26633-26643 GO:0010467 denotes expression
T12797 26662-26682 UBERON:0004883 denotes pulmonary mesenchyme
T12798 26689-26694 UBERON:0009912 denotes lobar
T12799 26753-26762 GO:0010467 denotes expressed
T12800 26770-26780 UBERON:0003104 denotes mesenchyme
T12801 26810-26814 UBERON:0009912 denotes lobe
T12802 26843-26848 UBERON:0009912 denotes lobes
T12803 26898-26902 UBERON:0009912 denotes lobe
T12804 26917-26921 UBERON:0009912 denotes lobe
T12805 26946-26950 PR:000017653 denotes Fog2
T12806 27008-27013 UBERON:0009912 denotes lobes
T12807 27048-27052 PR:000017653 denotes Fog2
T12808 27094-27098 PR:000017653 denotes Fog2
T12809 27099-27104 UBERON:0002048 denotes lungs
T12810 27196-27200 PR:000017653 denotes Fog2
T12811 27201-27206 UBERON:0002048 denotes lungs
T12812 27267-27272 UBERON:0009912 denotes lobes
T12813 27322-27327 UBERON:0002048 denotes lungs
T12814 27393-27397 PR:000017653 denotes Fog2
T12815 27405-27410 NCBITaxon:10088 denotes mouse
T12816 27444-27457 UBERON:0001103 denotes diaphragmatic
T12817 27486-27495 UBERON:0002048 denotes pulmonary
T12818 27559-27563 SO:0000704 denotes gene
T12819 27602-27606 UBERON:0002048 denotes lung
T12820 27602-27606 _FRAGMENT denotes lung
T12821 27621-27632 GO:0030324 denotes development
T12822 27611-27620 UBERON:0001103 denotes diaphragm
T12823 27611-27632 GO:0060539 denotes diaphragm development
T12824 27695-27699 PR:000017653 denotes Fog2
T12825 27732-27736 PR:000017653 denotes Fog2
T12826 27747-27752 NCBITaxon:10088 denotes mouse
T12827 27766-27775 UBERON:0001103 denotes diaphragm
T12828 27766-27775 _FRAGMENT denotes diaphragm
T12829 27785-27796 GO:0060539 denotes development
T12830 27780-27784 UBERON:0002048 denotes lung
T12831 27780-27796 GO:0030324 denotes lung development
T12832 28016-28021 NCBITaxon:9606 denotes human
T14377 28325-28332 SO:0000704 denotes Genetic
T14378 28348-28353 NCBITaxon:10088 denotes mouse
T14379 28454-28458 NCBITaxon:10088 denotes mice
T14380 28468-28475 SO:0000704 denotes genetic
T14381 28562-28566 NCBITaxon:10088 denotes Mice
T14382 28595-28599 PR:000017653 denotes Fog2
T14383 28613-28617 SO:0000704 denotes gene
T15184 28704-28708 NCBITaxon:10088 denotes mice
T15185 28716-28727 GO:0007565 denotes pregnancies
T15186 28770-28777 UBERON:0000922 denotes embryos
T15187 28779-28786 UBERON:0000922 denotes Embryos
T15188 28866-28873 UBERON:0000922 denotes embryos
T15189 28941-28950 UBERON:0001103 denotes diaphragm
T15190 28952-28957 UBERON:0002048 denotes lungs
T15191 28963-28968 UBERON:0000948 denotes heart
T15192 28988-28993 UBERON:0002048 denotes lungs
T15193 28998-29019 UBERON:0007196 denotes tracheobronchial tree
T15194 29052-29062 UBERON:0001103 denotes diaphragms
T15195 29088-29096 UBERON:0000915 denotes thoracic
T15196 29097-29103 UBERON:0000479 denotes tissue
T15197 29125-29132 UBERON:0000922 denotes embryos
T15198 29138-29142 UBERON:0002048 denotes lung
T15199 29160-29165 UBERON:0002048 denotes lungs
T15200 29192-29199 UBERON:0000922 denotes embryos
T15201 29346-29354 CHEBI:33284 denotes nutrient
T15202 29355-29362 CHEBI:60004 denotes mixture
T15203 29454-29460 NCBITaxon:27592 denotes bovine
T15204 29461-29466 UBERON:0001977 denotes serum
T15205 29504-29514 CHEBI:17334 denotes penicillin
T15206 29527-29539 CHEBI:17076 denotes streptomycin
T15207 29557-29571 CHEBI:2682 denotes amphotericin B
T15208 29573-29577 UBERON:0002048 denotes Lung
T15209 29624-29627 CHEBI:16526 denotes CO2
T15210 29790-29794 NCBITaxon:10088 denotes mice
T15211 29808-29812 PR:000033987 denotes lacZ
T15212 29813-29817 SO:0000704 denotes gene
T15213 29832-29836 PR:000017653 denotes Fog2
T15214 29837-29845 SO:0000167 denotes promoter
T15215 29891-29898 NCBITaxon:33208 denotes animals
T15216 29904-29908 PR:000033987 denotes lacZ
T15217 29909-29913 SO:0000704 denotes gene
T15218 29954-29958 PR:000017653 denotes Fog2
T15219 29990-30000 GO:0010467 denotes expression
T15220 30021-30029 SO:0001817 denotes in frame
T15221 30068-30072 PR:000017653 denotes FOG2
T15222 30086-30090 PR:000017653 denotes Fog2
T15223 30091-30095 PR:000033987 denotes lacZ
T15224 30121-30125 SO:0000243 denotes ires
T15225 30131-30139 SO:0005853 denotes cassette
T15226 30161-30167 SO:0001023 denotes allele
T15227 30171-30175 PR:000017653 denotes Fog2
T15228 30176-30180 SO:0000704 denotes gene
T15229 30186-30190 PR:000017653 denotes Fog2
T15230 30191-30195 PR:000033987 denotes LacZ
T15231 30268-30276 CL:0002322 denotes ES cells
T15232 30377-30388 UBERON:0000358 denotes blastocysts
T15233 30390-30394 PR:000017653 denotes Fog2
T15234 30395-30399 PR:000033987 denotes lacZ
T15235 30405-30412 NCBITaxon:33208 denotes animals
T15236 30467-30471 PR:000033987 denotes lacZ
T15237 30472-30482 GO:0010467 denotes Expression
T15238 30502-30511 UBERON:0000922 denotes embryonic
T15239 30512-30517 UBERON:0002048 denotes lungs
T15240 30577-30582 CHEBI:75055 denotes X-gal
T15959 30647-30652 NCBITaxon:10088 denotes mouse
T15960 30700-30708 UBERON:0000915 denotes thoracic
T15961 30709-30725 UBERON:0005291 denotes embryonic tissue
T15962 30758-30764 SO:0000112 denotes primer
T15963 30792-30796 PR:000017653 denotes Fog2
T15964 30797-30801 SO:0000704 denotes gene
T15965 30841-30848 SO:0000112 denotes primers
T15966 30874-30881 GO:0008380 denotes spliced
T15967 30882-30891 _FRAGMENT denotes region of
T15968 30896-30900 SO:0000842 denotes gene
T15969 31009-31020 SO:0000006 denotes PCR product
T15970 31044-31050 SO:0000440 denotes vector
T15971 31147-31151 SO:0000704 denotes gene
T15972 31161-31168 SO:0000112 denotes primers
T15973 31219-31223 SO:0000704 denotes Gene
T16269 31277-31290 GO:0097617 denotes hybridization
T16270 31336-31339 CHEBI:73702 denotes wax
T16271 31393-31406 GO:0097617 denotes hybridization
T16272 31446-31449 CHEBI:37983 denotes 35S
T16273 31503-31510 SO:0000155 denotes plasmid
T16274 31525-31535 GO:0097617 denotes hybridized
T16275 31539-31545 UBERON:0000479 denotes tissue
T16276 31556-31562 GO:0005634 denotes Nuclei
T16648 31670-31675 NCBITaxon:9606 denotes Human
T16649 31755-31761 CHEBI:15882 denotes phenol
T16650 31762-31772 CHEBI:35255 denotes chloroform
T16651 31809-31816 UBERON:0000479 denotes tissues
T16652 31841-31848 SO:0000112 denotes Primers
T16653 31874-31878 PR:000017653 denotes FOG2
T16654 31879-31891 SO:0000195 denotes coding exons
T16655 31900-31902 SO:0000028 denotes bp
T16656 31906-31914 SO:0000357 denotes flanking
T16657 32018-32024 SO:0000112 denotes Primer
T16658 32112-32116 SO:0000704 denotes Gene
T16659 32194-32199 UBERON:0000178 denotes blood
T16660 32225-32230 UBERON:0000178 denotes blood
T16661 32432-32435 SO:0000694 denotes SNP
T5124 10460-10465 GO:0007567 denotes birth
R235 T2478 T2477 _lexicallyChainedTo development,diaphragmatic
R1800 T7829 T7828 _lexicallyChainedTo Development,Lung
R1801 T7837 T7836 _lexicallyChainedTo development,pulmonary
R2524 T9823 T9822 _lexicallyChainedTo liver,left lobe of
R2996 T12735 T12734 _lexicallyChainedTo diaphragm,formation of
R2997 T12751 T12750 _lexicallyChainedTo differentiation,cell
R2998 T12760 T12759 _lexicallyChainedTo 6,Gatas
R2999 T12766 T12765 _lexicallyChainedTo development,cardiac
R3000 T12821 T12820 _lexicallyChainedTo development,lung
R3001 T12829 T12828 _lexicallyChainedTo development,diaphragm
R4579 T15968 T15967 _lexicallyChainedTo gene,region of
R1 T899 T898 _lexicallyChainedTo Development,Diaphragm

2_test

Id Subject Object Predicate Lexical cue
16103912-8982563-85559724 3242-3243 8982563 denotes 1
16103912-12720181-85559725 4013-4014 12720181 denotes 2
16103912-15136994-85559726 4015-4016 15136994 denotes 3
16103912-12949279-85559727 4189-4190 12949279 denotes 4
16103912-15770591-85559728 4525-4526 15770591 denotes 5
16103912-11877660-85559729 4527-4528 11877660 denotes 6
16103912-11370980-85559730 4608-4609 11370980 denotes 7
16103912-15065021-85559731 4895-4896 15065021 denotes 8
16103912-10685274-85559731 4895-4896 10685274 denotes 8
16103912-11283873-85559731 4895-4896 11283873 denotes 8
16103912-15704183-85559731 4895-4896 15704183 denotes 8
16103912-12725592-85559732 5495-5497 12725592 denotes 12
16103912-9788565-85559733 5498-5500 9788565 denotes 13
16103912-11818962-85559734 5926-5928 11818962 denotes 14
16103912-11818962-85559735 6987-6989 11818962 denotes 14
16103912-9457677-85559736 7275-7277 9457677 denotes 15
16103912-10892744-85559737 11526-11528 10892744 denotes 16
16103912-10892744-85559738 12179-12181 10892744 denotes 16
16103912-10696067-85559739 13459-13461 10696067 denotes 17
16103912-9355800-85559740 13462-13464 9355800 denotes 18
16103912-11063939-85559741 16654-16656 11063939 denotes 19
16103912-10066685-85559742 16657-16659 10066685 denotes 20
16103912-10696067-85559743 16781-16783 10696067 denotes 17
16103912-12388344-85559744 16784-16786 12388344 denotes 21
16103912-10226008-85559745 16787-16789 10226008 denotes 22
16103912-10079225-85559746 17013-17015 10079225 denotes 23
16103912-7651534-85559747 17159-17161 7651534 denotes 24
16103912-8681797-85559748 17162-17164 8681797 denotes 25
16103912-13726619-85559749 18930-18932 13726619 denotes 26
16103912-7065526-85559750 19651-19653 7065526 denotes 28
16103912-7179186-85559751 19764-19766 7179186 denotes 29
16103912-957074-85559752 21695-21697 957074 denotes 30
16103912-3783371-85559753 21698-21700 3783371 denotes 31
16103912-12692831-85559754 21931-21933 12692831 denotes 32
16103912-8724727-85559755 22438-22440 8724727 denotes 33
16103912-2809986-85559756 22441-22443 2809986 denotes 34
16103912-12725592-85559757 22552-22554 12725592 denotes 12
16103912-8982564-85559758 22555-22557 8982564 denotes 35
16103912-7815446-85559759 22841-22843 7815446 denotes 36
16103912-8953633-85559760 22844-22846 8953633 denotes 37
16103912-6601906-85559761 22990-22992 6601906 denotes 38
16103912-8896572-85559762 23697-23699 8896572 denotes 41
16103912-12508321-85559763 24172-24174 12508321 denotes 42
16103912-11090558-85559764 24466-24468 11090558 denotes 43
16103912-15659346-85559765 25181-25183 15659346 denotes 44
16103912-11382775-85559766 25184-25186 11382775 denotes 45
16103912-10696067-85559767 25700-25702 10696067 denotes 17
16103912-6894915-85559768 25733-25735 6894915 denotes 46
16103912-8982573-85559769 25839-25841 8982573 denotes 48
16103912-10751355-85559770 26046-26048 10751355 denotes 49
16103912-11076806-85559770 26046-26048 11076806 denotes 49
16103912-10646789-85559770 26046-26048 10646789 denotes 49
16103912-11083423-85559771 26200-26202 11083423 denotes 52
16103912-10892744-85559772 28629-28631 10892744 denotes 16
16103912-10948528-85559773 31421-31423 10948528 denotes 53
16103912-7516909-85559774 31785-31787 7516909 denotes 54
T19249 3242-3243 8982563 denotes 1
T63223 4013-4014 12720181 denotes 2
T54075 4015-4016 15136994 denotes 3
T97796 4189-4190 12949279 denotes 4
T1554 4525-4526 15770591 denotes 5
T69528 4527-4528 11877660 denotes 6
T82541 4608-4609 11370980 denotes 7
T46569 4895-4896 15065021 denotes 8
T74385 4895-4896 10685274 denotes 8
T55607 4895-4896 11283873 denotes 8
T71390 4895-4896 15704183 denotes 8
T44365 5495-5497 12725592 denotes 12
T34234 5498-5500 9788565 denotes 13
T84929 5926-5928 11818962 denotes 14
T20943 6987-6989 11818962 denotes 14
T62259 7275-7277 9457677 denotes 15
T65342 11526-11528 10892744 denotes 16
T5817 12179-12181 10892744 denotes 16
T66232 13459-13461 10696067 denotes 17
T74273 13462-13464 9355800 denotes 18
T90741 16654-16656 11063939 denotes 19
T7030 16657-16659 10066685 denotes 20
T63606 16781-16783 10696067 denotes 17
T80598 16784-16786 12388344 denotes 21
T49937 16787-16789 10226008 denotes 22
T83298 17013-17015 10079225 denotes 23
T51026 17159-17161 7651534 denotes 24
T15263 17162-17164 8681797 denotes 25
T38411 18930-18932 13726619 denotes 26
T80890 19651-19653 7065526 denotes 28
T67813 19764-19766 7179186 denotes 29
T12058 21695-21697 957074 denotes 30
T42018 21698-21700 3783371 denotes 31
T83269 21931-21933 12692831 denotes 32
T54695 22438-22440 8724727 denotes 33
T9218 22441-22443 2809986 denotes 34
T6329 22552-22554 12725592 denotes 12
T4249 22555-22557 8982564 denotes 35
T59577 22841-22843 7815446 denotes 36
T58251 22844-22846 8953633 denotes 37
T12323 22990-22992 6601906 denotes 38
T40209 23697-23699 8896572 denotes 41
T58636 24172-24174 12508321 denotes 42
T14097 24466-24468 11090558 denotes 43
T16321 25181-25183 15659346 denotes 44
T5633 25184-25186 11382775 denotes 45
T24984 25700-25702 10696067 denotes 17
T85757 25733-25735 6894915 denotes 46
T18163 25839-25841 8982573 denotes 48
T43074 26046-26048 10751355 denotes 49
T39269 26046-26048 11076806 denotes 49
T12212 26046-26048 10646789 denotes 49
T75735 26200-26202 11083423 denotes 52
T59733 28629-28631 10892744 denotes 16
T84674 31421-31423 10948528 denotes 53
T11695 31785-31787 7516909 denotes 54

Biotea

Id Subject Object Predicate Lexical cue
T474 21-27 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78727 denotes Normal
T475 1192-1198 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78727 denotes normal
T476 21-27 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C121439 denotes Normal
T477 1192-1198 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C121439 denotes normal
T478 21-27 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14165 denotes Normal
T479 1192-1198 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14165 denotes normal
T480 21-27 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48554 denotes Normal
T481 1192-1198 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48554 denotes normal
T482 21-27 http://purl.bioontology.org/ontology/SNOMEDCT/17621005 denotes Normal
T483 1192-1198 http://purl.bioontology.org/ontology/SNOMEDCT/17621005 denotes normal
T484 28-37 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C23633 denotes Diaphragm
T485 1100-1109 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C23633 denotes diaphragm
T486 1199-1208 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C23633 denotes diaphragm
T487 28-37 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49920 denotes Diaphragm
T488 1100-1109 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49920 denotes diaphragm
T489 1199-1208 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49920 denotes diaphragm
T490 28-37 http://purl.bioontology.org/ontology/MESH/D003964 denotes Diaphragm
T491 1100-1109 http://purl.bioontology.org/ontology/MESH/D003964 denotes diaphragm
T492 1199-1208 http://purl.bioontology.org/ontology/MESH/D003964 denotes diaphragm
T493 28-37 http://purl.bioontology.org/ontology/OMIM/MTHU001435 denotes Diaphragm
T494 1100-1109 http://purl.bioontology.org/ontology/OMIM/MTHU001435 denotes diaphragm
T495 1199-1208 http://purl.bioontology.org/ontology/OMIM/MTHU001435 denotes diaphragm
T496 28-37 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12702 denotes Diaphragm
T497 1100-1109 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12702 denotes diaphragm
T498 1199-1208 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12702 denotes diaphragm
T499 28-37 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C42767 denotes Diaphragm
T500 1100-1109 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C42767 denotes diaphragm
T501 1199-1208 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C42767 denotes diaphragm
T502 28-37 http://purl.bioontology.org/ontology/MEDDRA/10012704 denotes Diaphragm
T503 1100-1109 http://purl.bioontology.org/ontology/MEDDRA/10012704 denotes diaphragm
T504 1199-1208 http://purl.bioontology.org/ontology/MEDDRA/10012704 denotes diaphragm
T505 28-37 http://purl.bioontology.org/ontology/NDDF/YD denotes Diaphragm
T506 1100-1109 http://purl.bioontology.org/ontology/NDDF/YD denotes diaphragm
T507 1199-1208 http://purl.bioontology.org/ontology/NDDF/YD denotes diaphragm
T508 28-37 http://purl.org/sig/ont/fma/fma13295 denotes Diaphragm
T509 1100-1109 http://purl.org/sig/ont/fma/fma13295 denotes diaphragm
T510 1199-1208 http://purl.org/sig/ont/fma/fma13295 denotes diaphragm
T511 28-37 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47890 denotes Diaphragm
T512 1100-1109 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47890 denotes diaphragm
T513 1199-1208 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47890 denotes diaphragm
T514 28-37 http://purl.bioontology.org/ontology/SNOMEDCT/5798000 denotes Diaphragm
T515 1100-1109 http://purl.bioontology.org/ontology/SNOMEDCT/5798000 denotes diaphragm
T516 1199-1208 http://purl.bioontology.org/ontology/SNOMEDCT/5798000 denotes diaphragm
T517 42-58 http://purl.obolibrary.org/obo/GO_0030324 denotes Lung Development
T518 1213-1229 http://purl.obolibrary.org/obo/GO_0030324 denotes lung development
T519 42-58 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19443 denotes Lung Development
T520 1213-1229 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19443 denotes lung development
T521 42-46 http://purl.bioontology.org/ontology/MESH/D008168 denotes Lung
T522 1213-1217 http://purl.bioontology.org/ontology/MESH/D008168 denotes lung
T523 42-46 http://purl.bioontology.org/ontology/OMIM/MTHU000106 denotes Lung
T524 1213-1217 http://purl.bioontology.org/ontology/OMIM/MTHU000106 denotes lung
T525 42-46 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C23402 denotes Lung
T526 1213-1217 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C23402 denotes lung
T527 42-46 http://purl.bioontology.org/ontology/OMIM/MTHU016106 denotes Lung
T528 1213-1217 http://purl.bioontology.org/ontology/OMIM/MTHU016106 denotes lung
T529 42-46 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12468 denotes Lung
T530 1213-1217 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12468 denotes lung
T531 42-46 http://purl.obolibrary.org/obo/UBERON_0002048 denotes Lung
T532 1213-1217 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T533 42-46 http://purl.obolibrary.org/obo/UBERON_0002048 denotes Lung
T534 1213-1217 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T535 42-46 http://purl.org/sig/ont/fma/fma7195 denotes Lung
T536 1213-1217 http://purl.org/sig/ont/fma/fma7195 denotes lung
T537 42-46 http://purl.bioontology.org/ontology/SNOMEDCT/39607008 denotes Lung
T538 1213-1217 http://purl.bioontology.org/ontology/SNOMEDCT/39607008 denotes lung
T539 47-58 http://purl.obolibrary.org/obo/GO_0032502 denotes Development
T540 526-537 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T541 1218-1229 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T542 1422-1433 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T543 47-58 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18732 denotes Development
T544 526-537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18732 denotes development
T545 1218-1229 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18732 denotes development
T546 1422-1433 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18732 denotes development
T547 47-58 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96110 denotes Development
T548 526-537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96110 denotes development
T549 1218-1229 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96110 denotes development
T550 1422-1433 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96110 denotes development
T551 47-58 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17770 denotes Development
T552 319-332 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17770 denotes developmental
T553 526-537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17770 denotes development
T554 1218-1229 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17770 denotes development
T555 1422-1433 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17770 denotes development
T556 1542-1555 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17770 denotes developmental
T557 47-58 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133991 denotes Development
T558 526-537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133991 denotes development
T559 1218-1229 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133991 denotes development
T560 1422-1433 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133991 denotes development
T561 47-58 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84377 denotes Development
T562 526-537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84377 denotes development
T563 1218-1229 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84377 denotes development
T564 1422-1433 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84377 denotes development
T565 62-66 http://purl.obolibrary.org/obo/PR_O89094 denotes Mice
T566 400-404 http://purl.obolibrary.org/obo/PR_O89094 denotes mice
T567 62-66 http://purl.obolibrary.org/obo/PR_000005054 denotes Mice
T568 400-404 http://purl.obolibrary.org/obo/PR_000005054 denotes mice
T569 62-66 http://purl.bioontology.org/ontology/MESH/D051379 denotes Mice
T570 400-404 http://purl.bioontology.org/ontology/MESH/D051379 denotes mice
T571 62-66 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14238 denotes Mice
T572 400-404 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14238 denotes mice
T573 71-77 http://purl.bioontology.org/ontology/MESH/D006801 denotes Humans
T574 137-168 http://purl.bioontology.org/ontology/ICD10/Q79.0 denotes Congenital diaphragmatic hernia
T575 1478-1509 http://purl.bioontology.org/ontology/ICD10/Q79.0 denotes congenital diaphragmatic hernia
T576 137-168 http://purl.bioontology.org/ontology/SNOMEDCT/17190001 denotes Congenital diaphragmatic hernia
T577 1478-1509 http://purl.bioontology.org/ontology/SNOMEDCT/17190001 denotes congenital diaphragmatic hernia
T578 137-168 http://purl.bioontology.org/ontology/OMIM/MTHU018825 denotes Congenital diaphragmatic hernia
T579 1478-1509 http://purl.bioontology.org/ontology/OMIM/MTHU018825 denotes congenital diaphragmatic hernia
T580 137-168 http://purl.bioontology.org/ontology/MEDLINEPLUS/C0235833 denotes Congenital diaphragmatic hernia
T581 1478-1509 http://purl.bioontology.org/ontology/MEDLINEPLUS/C0235833 denotes congenital diaphragmatic hernia
T582 137-168 http://purl.bioontology.org/ontology/MEDDRA/10010439 denotes Congenital diaphragmatic hernia
T583 1478-1509 http://purl.bioontology.org/ontology/MEDDRA/10010439 denotes congenital diaphragmatic hernia
T584 137-168 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98893 denotes Congenital diaphragmatic hernia
T585 1478-1509 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98893 denotes congenital diaphragmatic hernia
T586 137-147 http://purl.bioontology.org/ontology/SNOMEDCT/255399007 denotes Congenital
T587 179-189 http://purl.bioontology.org/ontology/SNOMEDCT/255399007 denotes congenital
T588 1356-1366 http://purl.bioontology.org/ontology/SNOMEDCT/255399007 denotes congenital
T589 1478-1488 http://purl.bioontology.org/ontology/SNOMEDCT/255399007 denotes congenital
T590 137-147 http://purl.bioontology.org/ontology/MESH/Q000151 denotes Congenital
T591 179-189 http://purl.bioontology.org/ontology/MESH/Q000151 denotes congenital
T592 1356-1366 http://purl.bioontology.org/ontology/MESH/Q000151 denotes congenital
T593 1478-1488 http://purl.bioontology.org/ontology/MESH/Q000151 denotes congenital
T594 137-147 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99210 denotes Congenital
T595 179-189 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99210 denotes congenital
T596 1356-1366 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99210 denotes congenital
T597 1478-1488 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99210 denotes congenital
T598 148-168 http://purl.bioontology.org/ontology/ICD10/K44 denotes diaphragmatic hernia
T599 1489-1509 http://purl.bioontology.org/ontology/ICD10/K44 denotes diaphragmatic hernia
T600 148-168 http://purl.bioontology.org/ontology/MEDDRA/10012713 denotes diaphragmatic hernia
T601 1489-1509 http://purl.bioontology.org/ontology/MEDDRA/10012713 denotes diaphragmatic hernia
T602 148-168 http://purl.bioontology.org/ontology/NDFRT/N0000001517 denotes diaphragmatic hernia
T603 1489-1509 http://purl.bioontology.org/ontology/NDFRT/N0000001517 denotes diaphragmatic hernia
T604 148-168 http://purl.bioontology.org/ontology/SNOMEDCT/39839004 denotes diaphragmatic hernia
T605 1489-1509 http://purl.bioontology.org/ontology/SNOMEDCT/39839004 denotes diaphragmatic hernia
T606 148-168 http://purl.bioontology.org/ontology/OMIM/MTHU001436 denotes diaphragmatic hernia
T607 1489-1509 http://purl.bioontology.org/ontology/OMIM/MTHU001436 denotes diaphragmatic hernia
T608 148-168 http://purl.bioontology.org/ontology/MEDLINEPLUS/C0019284 denotes diaphragmatic hernia
T609 1489-1509 http://purl.bioontology.org/ontology/MEDLINEPLUS/C0019284 denotes diaphragmatic hernia
T610 148-168 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34687 denotes diaphragmatic hernia
T611 1489-1509 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34687 denotes diaphragmatic hernia
T612 148-161 http://purl.bioontology.org/ontology/SNOMEDCT/263734003 denotes diaphragmatic
T613 190-203 http://purl.bioontology.org/ontology/SNOMEDCT/263734003 denotes diaphragmatic
T614 512-525 http://purl.bioontology.org/ontology/SNOMEDCT/263734003 denotes diaphragmatic
T615 807-820 http://purl.bioontology.org/ontology/SNOMEDCT/263734003 denotes diaphragmatic
T616 1367-1380 http://purl.bioontology.org/ontology/SNOMEDCT/263734003 denotes diaphragmatic
T617 1489-1502 http://purl.bioontology.org/ontology/SNOMEDCT/263734003 denotes diaphragmatic
T618 162-168 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34685 denotes hernia
T619 1503-1509 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34685 denotes hernia
T620 162-168 http://purl.bioontology.org/ontology/OMIM/MTHU012924 denotes hernia
T621 1503-1509 http://purl.bioontology.org/ontology/OMIM/MTHU012924 denotes hernia
T622 162-168 http://purl.bioontology.org/ontology/NDFRT/N0000001516 denotes hernia
T623 1503-1509 http://purl.bioontology.org/ontology/NDFRT/N0000001516 denotes hernia
T624 162-168 http://purl.bioontology.org/ontology/MESH/D006547 denotes hernia
T625 1503-1509 http://purl.bioontology.org/ontology/MESH/D006547 denotes hernia
T626 162-168 http://purl.bioontology.org/ontology/MEDLINEPLUS/C0019270 denotes hernia
T627 1503-1509 http://purl.bioontology.org/ontology/MEDLINEPLUS/C0019270 denotes hernia
T628 162-168 http://purl.bioontology.org/ontology/ICD10/K40-K46.9 denotes hernia
T629 1503-1509 http://purl.bioontology.org/ontology/ICD10/K40-K46.9 denotes hernia
T630 162-168 http://purl.bioontology.org/ontology/SNOMEDCT/414403008 denotes hernia
T631 1503-1509 http://purl.bioontology.org/ontology/SNOMEDCT/414403008 denotes hernia
T632 162-168 http://purl.bioontology.org/ontology/SNOMEDCT/52515009 denotes hernia
T633 1503-1509 http://purl.bioontology.org/ontology/SNOMEDCT/52515009 denotes hernia
T634 162-168 http://purl.bioontology.org/ontology/MEDDRA/10019909 denotes hernia
T635 1503-1509 http://purl.bioontology.org/ontology/MEDDRA/10019909 denotes hernia
T636 216-231 http://purl.bioontology.org/ontology/SNOMEDCT/47429007 denotes associated with
T637 216-226 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25281 denotes associated
T638 244-253 http://purl.bioontology.org/ontology/MESH/Q000401 denotes mortality
T639 244-253 http://purl.bioontology.org/ontology/MESH/D009026 denotes mortality
T640 244-253 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16880 denotes mortality
T641 258-267 http://purl.bioontology.org/ontology/MESH/D009017 denotes morbidity
T642 258-267 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16877 denotes morbidity
T643 294-309 http://purl.bioontology.org/ontology/OMIM/MTHU000008 denotes molecular basis
T644 294-303 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25574 denotes molecular
T645 304-309 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25430 denotes basis
T646 304-309 http://purl.bioontology.org/ontology/NDFRT/N0000021972 denotes basis
T647 319-332 http://purl.bioontology.org/ontology/SNOMEDCT/278923009 denotes developmental
T648 1542-1555 http://purl.bioontology.org/ontology/SNOMEDCT/278923009 denotes developmental
T649 346-353 http://purl.bioontology.org/ontology/SNOMEDCT/261665006 denotes unknown
T650 346-353 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38311 denotes unknown
T651 346-353 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C150001 denotes unknown
T652 346-353 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C150002 denotes unknown
T653 346-353 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C150003 denotes unknown
T654 346-353 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C123772 denotes unknown
T655 346-353 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17998 denotes unknown
T656 361-369 http://purl.bioontology.org/ontology/MESH/Q000032 denotes analysis
T657 900-908 http://purl.bioontology.org/ontology/MESH/Q000032 denotes analysis
T658 361-369 http://purl.bioontology.org/ontology/SNOMEDCT/272389005 denotes analysis
T659 900-908 http://purl.bioontology.org/ontology/SNOMEDCT/272389005 denotes analysis
T660 361-369 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25391 denotes analysis
T661 900-908 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25391 denotes analysis
T662 387-394 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C42885 denotes derived
T663 387-394 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73924 denotes derived
T664 387-394 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C69271 denotes derived
T665 387-394 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C81197 denotes derived
T666 405-417 http://purl.bioontology.org/ontology/SNOMEDCT/28995006 denotes treated with
T667 405-412 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25705 denotes treated
T668 405-412 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C70742 denotes treated
T669 418-439 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26563 denotes N-ethyl-N-nitrosourea
T670 602-623 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26563 denotes N-ethyl-N-nitrosourea
T671 418-439 http://purl.obolibrary.org/obo/CHEBI_23995 denotes N-ethyl-N-nitrosourea
T672 602-623 http://purl.obolibrary.org/obo/CHEBI_23995 denotes N-ethyl-N-nitrosourea
T673 428-439 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C699 denotes nitrosourea
T674 612-623 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C699 denotes nitrosourea
T675 444-454 http://purl.bioontology.org/ontology/SNOMEDCT/7882003 denotes identified
T676 669-679 http://purl.bioontology.org/ontology/SNOMEDCT/7882003 denotes identified
T677 444-454 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25737 denotes identified
T678 669-679 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25737 denotes identified
T679 457-465 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16885 denotes mutation
T680 632-640 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16885 denotes mutation
T681 682-690 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16885 denotes mutation
T682 928-936 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16885 denotes mutation
T683 457-465 http://purl.bioontology.org/ontology/MESH/D009154 denotes mutation
T684 632-640 http://purl.bioontology.org/ontology/MESH/D009154 denotes mutation
T685 682-690 http://purl.bioontology.org/ontology/MESH/D009154 denotes mutation
T686 872-881 http://purl.bioontology.org/ontology/MESH/D009154 denotes mutations
T687 928-936 http://purl.bioontology.org/ontology/MESH/D009154 denotes mutation
T688 457-465 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45576 denotes mutation
T689 632-640 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45576 denotes mutation
T690 682-690 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45576 denotes mutation
T691 928-936 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45576 denotes mutation
T692 478-498 http://purl.bioontology.org/ontology/OMIM/MTHU004127 denotes pulmonary hypoplasia
T693 832-852 http://purl.bioontology.org/ontology/OMIM/MTHU004127 denotes pulmonary hypoplasia
T694 1048-1068 http://purl.bioontology.org/ontology/OMIM/MTHU004127 denotes pulmonary hypoplasia
T695 478-498 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99035 denotes pulmonary hypoplasia
T696 832-852 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99035 denotes pulmonary hypoplasia
T697 1048-1068 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99035 denotes pulmonary hypoplasia
T698 478-498 http://purl.bioontology.org/ontology/MEDDRA/10037407 denotes pulmonary hypoplasia
T699 832-852 http://purl.bioontology.org/ontology/MEDDRA/10037407 denotes pulmonary hypoplasia
T700 1048-1068 http://purl.bioontology.org/ontology/MEDDRA/10037407 denotes pulmonary hypoplasia
T701 478-487 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13304 denotes pulmonary
T702 832-841 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13304 denotes pulmonary
T703 1048-1057 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13304 denotes pulmonary
T704 1412-1421 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13304 denotes pulmonary
T705 1532-1541 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13304 denotes pulmonary
T706 478-487 http://purl.bioontology.org/ontology/SNOMEDCT/738985004 denotes pulmonary
T707 832-841 http://purl.bioontology.org/ontology/SNOMEDCT/738985004 denotes pulmonary
T708 1048-1057 http://purl.bioontology.org/ontology/SNOMEDCT/738985004 denotes pulmonary
T709 1412-1421 http://purl.bioontology.org/ontology/SNOMEDCT/738985004 denotes pulmonary
T710 1532-1541 http://purl.bioontology.org/ontology/SNOMEDCT/738985004 denotes pulmonary
T711 478-487 http://purl.bioontology.org/ontology/SNOMEDCT/264164005 denotes pulmonary
T712 832-841 http://purl.bioontology.org/ontology/SNOMEDCT/264164005 denotes pulmonary
T713 1048-1057 http://purl.bioontology.org/ontology/SNOMEDCT/264164005 denotes pulmonary
T714 1412-1421 http://purl.bioontology.org/ontology/SNOMEDCT/264164005 denotes pulmonary
T715 1532-1541 http://purl.bioontology.org/ontology/SNOMEDCT/264164005 denotes pulmonary
T716 488-498 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C120893 denotes hypoplasia
T717 842-852 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C120893 denotes hypoplasia
T718 1058-1068 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C120893 denotes hypoplasia
T719 488-498 http://purl.bioontology.org/ontology/SNOMEDCT/55199003 denotes hypoplasia
T720 842-852 http://purl.bioontology.org/ontology/SNOMEDCT/55199003 denotes hypoplasia
T721 1058-1068 http://purl.bioontology.org/ontology/SNOMEDCT/55199003 denotes hypoplasia
T722 503-511 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78802 denotes abnormal
T723 732-740 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78802 denotes abnormal
T724 503-511 http://purl.bioontology.org/ontology/SNOMEDCT/263654008 denotes abnormal
T725 732-740 http://purl.bioontology.org/ontology/SNOMEDCT/263654008 denotes abnormal
T726 503-511 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25401 denotes abnormal
T727 732-740 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25401 denotes abnormal
T728 539-543 http://purl.obolibrary.org/obo/PR_000017653 denotes Fog2
T729 545-550 http://purl.obolibrary.org/obo/PR_000017653 denotes Zfpm2
T730 664-668 http://purl.obolibrary.org/obo/PR_000017653 denotes Fog2
T731 885-889 http://purl.obolibrary.org/obo/PR_000017653 denotes FOG2
T732 1171-1175 http://purl.obolibrary.org/obo/PR_000017653 denotes Fog2
T733 1280-1284 http://purl.obolibrary.org/obo/PR_000017653 denotes FOG2
T734 539-543 http://purl.obolibrary.org/obo/PR_Q8CCH7 denotes Fog2
T735 664-668 http://purl.obolibrary.org/obo/PR_Q8CCH7 denotes Fog2
T736 885-889 http://purl.obolibrary.org/obo/PR_Q8CCH7 denotes FOG2
T737 1171-1175 http://purl.obolibrary.org/obo/PR_Q8CCH7 denotes Fog2
T738 1280-1284 http://purl.obolibrary.org/obo/PR_Q8CCH7 denotes FOG2
T739 539-543 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102765 denotes Fog2
T740 664-668 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102765 denotes Fog2
T741 885-889 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102765 denotes FOG2
T742 1171-1175 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102765 denotes Fog2
T743 1280-1284 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102765 denotes FOG2
T744 545-550 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102764 denotes Zfpm2
T745 552-556 http://purl.bioontology.org/ontology/MESH/D019532 denotes maps
T746 552-556 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16861 denotes maps
T747 568-579 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14353 denotes recombinant
T748 580-588 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25543 denotes interval
T749 580-588 http://purl.bioontology.org/ontology/SNOMEDCT/385673002 denotes interval
T750 580-588 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48921 denotes interval
T751 589-597 http://purl.bioontology.org/ontology/MESH/D017770 denotes carrying
T752 589-597 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C81005 denotes carrying
T753 624-640 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40987 denotes induced mutation
T754 624-640 http://purl.obolibrary.org/obo/OBI_0001154 denotes induced mutation
T755 624-631 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61367 denotes induced
T756 624-631 http://purl.bioontology.org/ontology/SNOMEDCT/16404004 denotes induced
T757 646-660 http://purl.obolibrary.org/obo/OBI_0000626 denotes DNA sequencing
T758 646-660 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C153598 denotes DNA sequencing
T759 646-649 http://purl.org/sig/ont/fma/fma74412 denotes DNA
T760 646-649 http://purl.obolibrary.org/obo/GO_0005574 denotes DNA
T761 646-649 http://purl.bioontology.org/ontology/MESH/D004247 denotes DNA
T762 646-649 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C135409 denotes DNA
T763 646-649 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C449 denotes DNA
T764 650-660 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18881 denotes sequencing
T765 650-660 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17565 denotes sequencing
T766 891-908 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17565 denotes Sequence analysis
T767 650-660 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116155 denotes sequencing
T768 703-713 http://purl.bioontology.org/ontology/SNOMEDCT/410609009 denotes donor site
T769 703-713 http://purl.bioontology.org/ontology/SNOMEDCT/410608001 denotes donor site
T770 703-708 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25168 denotes donor
T771 703-708 http://purl.obolibrary.org/obo/OBI_1110087 denotes donor
T772 703-708 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48284 denotes donor
T773 709-713 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13717 denotes site
T774 709-713 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37901 denotes site
T775 709-713 http://purl.bioontology.org/ontology/SNOMEDCT/10546003 denotes site
T776 709-713 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T777 709-713 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80403 denotes site
T778 741-751 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1936 denotes transcript
T779 752-760 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80216 denotes encoding
T780 773-780 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C64858 denotes protein
T781 773-780 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17021 denotes protein
T782 773-780 http://purl.obolibrary.org/obo/GO_0003675 denotes protein
T783 773-780 http://purl.org/sig/ont/fma/fma67257 denotes protein
T784 773-780 http://purl.obolibrary.org/obo/CHEBI_36080 denotes protein
T785 773-780 http://purl.bioontology.org/ontology/NDFRT/N0000148318 denotes protein
T786 773-780 http://purl.obolibrary.org/obo/PR_000000001 denotes protein
T787 773-780 http://purl.obolibrary.org/obo/PR_000000001 denotes protein
T788 773-780 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41172 denotes protein
T789 773-780 http://purl.bioontology.org/ontology/SNOMEDCT/88878007 denotes protein
T790 773-780 http://purl.bioontology.org/ontology/MEDDRA/10036987 denotes protein
T791 782-787 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14225 denotes Human
T792 1350-1355 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14225 denotes human
T793 782-787 http://purl.bioontology.org/ontology/STY/T016 denotes Human
T794 1350-1355 http://purl.bioontology.org/ontology/STY/T016 denotes human
T795 782-787 http://purl.bioontology.org/ontology/STY/T016 denotes Human
T796 1350-1355 http://purl.bioontology.org/ontology/STY/T016 denotes human
T797 782-787 http://purl.bioontology.org/ontology/STY/T016 denotes Human
T798 1350-1355 http://purl.bioontology.org/ontology/STY/T016 denotes human
T799 782-787 http://purl.bioontology.org/ontology/STY/T016 denotes Human
T800 1350-1355 http://purl.bioontology.org/ontology/STY/T016 denotes human
T801 782-787 http://purl.bioontology.org/ontology/STY/T016 denotes Human
T802 1350-1355 http://purl.bioontology.org/ontology/STY/T016 denotes human
T803 782-787 http://purl.bioontology.org/ontology/STY/T016 denotes Human
T804 1350-1355 http://purl.bioontology.org/ontology/STY/T016 denotes human
T805 782-787 http://purl.bioontology.org/ontology/STY/T016 denotes Human
T806 1350-1355 http://purl.bioontology.org/ontology/STY/T016 denotes human
T807 782-787 http://purl.bioontology.org/ontology/STY/T016 denotes Human
T808 1350-1355 http://purl.bioontology.org/ontology/STY/T016 denotes human
T809 782-787 http://purl.bioontology.org/ontology/STY/T016 denotes Human
T810 1350-1355 http://purl.bioontology.org/ontology/STY/T016 denotes human
T811 782-787 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T812 1350-1355 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T813 782-787 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T814 1350-1355 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T815 788-795 http://purl.bioontology.org/ontology/MESH/D001344 denotes autopsy
T816 788-795 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25153 denotes autopsy
T817 788-795 http://purl.bioontology.org/ontology/SNOMEDCT/29240004 denotes autopsy
T818 788-795 http://purl.bioontology.org/ontology/MEDDRA/10050117 denotes autopsy
T819 796-801 http://purl.bioontology.org/ontology/SNOMEDCT/398241000 denotes cases
T820 807-827 http://purl.bioontology.org/ontology/OMIM/MTHU009127 denotes diaphragmatic defect
T821 821-827 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43429 denotes defect
T822 821-827 http://purl.bioontology.org/ontology/SNOMEDCT/6920004 denotes defect
T823 858-867 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25214 denotes evaluated
T824 891-908 http://purl.bioontology.org/ontology/MESH/D017421 denotes Sequence analysis
T825 891-899 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43465 denotes Sequence
T826 891-899 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C89252 denotes Sequence
T827 891-899 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13299 denotes Sequence
T828 891-899 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25673 denotes Sequence
T829 891-899 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45374 denotes Sequence
T830 891-899 http://purl.obolibrary.org/obo/SO_0000001 denotes Sequence
T831 909-917 http://purl.bioontology.org/ontology/SNOMEDCT/263857004 denotes revealed
T832 920-936 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C93106 denotes de novo mutation
T833 920-936 http://purl.bioontology.org/ontology/OMIM/MTHU036578 denotes de novo mutation
T834 920-927 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28354 denotes de novo
T835 937-949 http://purl.bioontology.org/ontology/SNOMEDCT/79409006 denotes resulting in
T836 952-961 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133441 denotes premature
T838 967-972 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62019 denotes codon
T839 967-972 http://purl.bioontology.org/ontology/NDFRT/N0000170695 denotes codon
T840 967-972 http://purl.bioontology.org/ontology/MESH/D003062 denotes codon
T841 978-983 http://purl.bioontology.org/ontology/SNOMEDCT/410601007 denotes child
T842 978-983 http://purl.bioontology.org/ontology/SNOMEDCT/67822003 denotes child
T843 978-983 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C150886 denotes child
T844 978-983 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16423 denotes child
T845 978-983 http://purl.bioontology.org/ontology/MESH/D002648 denotes child
T846 978-983 http://purl.bioontology.org/ontology/NDFRT/N0000010205 denotes child
T847 988-992 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28554 denotes died
T848 988-992 http://purl.bioontology.org/ontology/SNOMEDCT/419099009 denotes died
T849 1006-1009 http://purl.bioontology.org/ontology/SNOMEDCT/258703001 denotes day
T850 1006-1009 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25301 denotes day
T851 1013-1017 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142142 denotes life
T852 1013-1017 http://purl.bioontology.org/ontology/MESH/D019369 denotes life
T853 1013-1017 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20203 denotes life
T854 1018-1030 http://purl.bioontology.org/ontology/SNOMEDCT/2603003 denotes secondary to
T855 1018-1027 http://purl.bioontology.org/ontology/SNOMEDCT/2603003 denotes secondary
T856 1018-1027 http://purl.bioontology.org/ontology/MESH/Q000556 denotes secondary
T857 1018-1027 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25667 denotes secondary
T858 1018-1027 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25666 denotes secondary
T859 1031-1037 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C121395 denotes severe
T860 1031-1037 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C122951 denotes severe
T861 1031-1037 http://purl.bioontology.org/ontology/SNOMEDCT/24484000 denotes severe
T862 1031-1037 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41340 denotes severe
T863 1031-1037 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156244 denotes severe
T864 1031-1037 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C70667 denotes severe
T865 1038-1047 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13332 denotes bilateral
T866 1038-1047 http://purl.bioontology.org/ontology/SNOMEDCT/51440002 denotes bilateral
T867 1119-1128 http://purl.obolibrary.org/obo/OGMS_0000023 denotes phenotype
T868 1119-1128 http://purl.bioontology.org/ontology/SNOMEDCT/8116006 denotes phenotype
T869 1119-1128 http://purl.bioontology.org/ontology/MESH/D010641 denotes phenotype
T870 1119-1128 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16977 denotes phenotype
T871 1129-1135 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C141290 denotes driven
T872 1154-1165 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62559 denotes established
T873 1154-1165 http://purl.bioontology.org/ontology/SNOMEDCT/263748003 denotes established
T874 1154-1165 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71155 denotes established
T875 1233-1237 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25199 denotes role
T876 1233-1237 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C42754 denotes role
T877 1233-1237 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43643 denotes role
T878 1233-1237 http://purl.bioontology.org/ontology/MESH/D012380 denotes role
T879 1233-1237 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48835 denotes role
T880 1233-1237 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C42768 denotes role
T881 1233-1237 http://purl.obolibrary.org/obo/BFO_0000023 denotes role
T882 1233-1237 http://purl.obolibrary.org/obo/BFO_0000023 denotes role
T883 1298-1302 http://purl.org/sig/ont/fma/fma74402 denotes gene
T884 1298-1302 http://purl.bioontology.org/ontology/SNOMEDCT/67271001 denotes gene
T885 1298-1302 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45520 denotes gene
T886 1298-1302 http://purl.obolibrary.org/obo/SO_0000704 denotes gene
T887 1298-1302 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612 denotes gene
T888 1321-1333 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T889 1321-1333 http://purl.bioontology.org/ontology/SNOMEDCT/263547006 denotes pathogenesis
T890 1321-1333 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18264 denotes pathogenesis
T891 1337-1349 http://purl.bioontology.org/ontology/OMIM/MTHU021422 denotes nonsyndromic
T892 1448-1458 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28362 denotes hypothesis
T893 1448-1458 http://purl.obolibrary.org/obo/OBI_0001908 denotes hypothesis
T894 1524-1531 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25251 denotes primary
T895 1556-1569 http://purl.bioontology.org/ontology/MEDLINEPLUS/C0000768 denotes abnormalities
T896 1556-1569 http://purl.bioontology.org/ontology/MESH/Q000002 denotes abnormalities
T466 8-16 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25652 denotes Required
T467 1179-1187 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25652 denotes required
T468 21-27 http://purl.bioontology.org/ontology/OMIM/MTHU002946 denotes Normal
T469 1192-1198 http://purl.bioontology.org/ontology/OMIM/MTHU002946 denotes normal
T470 21-27 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74593 denotes Normal
T471 1192-1198 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74593 denotes normal
T472 21-27 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C140746 denotes Normal
T473 1192-1198 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C140746 denotes normal
T837 962-972 http://purl.bioontology.org/ontology/NDFRT/N0000170697 denotes stop codon

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T941 28-37 _FRAGMENT denotes Diaphragm
T940 28-37 UBERON:0001103 denotes Diaphragm
T942 47-58 GO:0060539 denotes Development
T943 42-46 UBERON:0002048 denotes Lung
T944 42-58 GO:0030324 denotes Lung Development
T945 62-66 NCBITaxon:10088 denotes Mice
T946 71-77 NCBITaxon:9606 denotes Humans
T947 148-161 UBERON:0001103 denotes diaphragmatic
T948 190-203 UBERON:0001103 denotes diaphragmatic
T949 271-279 PATO_UBERON_EXT:neonate_or_newborn denotes neonates
T950 294-303 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T951 379-386 UBERON:0000922 denotes embryos
T952 400-404 NCBITaxon:10088 denotes mice
T953 418-439 CHEBI:23995 denotes N-ethyl-N-nitrosourea
T954 457-465 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T955 478-487 UBERON:0002048 denotes pulmonary
T956 512-525 UBERON:0001103 denotes diaphragmatic
T957 512-537 GO:0060539 denotes diaphragmatic development
T958 539-543 PR_EXT:000017653 denotes Fog2
T959 545-550 PR_EXT:000017653 denotes Zfpm2
T960 568-579 GO_SO_EXT:sequence_rearrangement_process denotes recombinant
T961 602-623 CHEBI:23995 denotes N-ethyl-N-nitrosourea
T962 632-640 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T963 646-649 CHEBI_SO_EXT:DNA denotes DNA
T964 664-668 PR_EXT:000017653 denotes Fog2
T965 682-690 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T966 696-702 GO:0008380 denotes splice
T967 696-713 SO_EXT:splice_donor denotes splice donor site
T968 741-751 SO_EXT:0000673 denotes transcript
T969 752-760 SO_EXT:sequence_coding_function denotes encoding
T970 763-772 SO_EXT:sequence_truncation_process denotes truncated
T971 773-780 CHEBI_PR_EXT:protein denotes protein
T972 782-787 NCBITaxon:9606 denotes Human
T973 807-820 UBERON:0001103 denotes diaphragmatic
T974 832-841 UBERON:0002048 denotes pulmonary
T975 872-881 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T976 885-889 PR_EXT:000017653 denotes FOG2
T977 891-899 SO_EXT:biological_sequence denotes Sequence
T978 928-936 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T979 952-972 SO_EXT:0001587 denotes premature stop codon
T980 978-983 NCBITaxon_UBERON_EXT:child denotes child
T981 988-992 GO:0016265 denotes died
T982 1013-1017 UBERON:0000104 denotes life
T983 1048-1057 UBERON:0002048 denotes pulmonary
T984 1087-1099 GO_EXT:muscle_structure_or_tissue_development denotes muscularized
T985 1100-1109 UBERON:0001103 denotes diaphragm
T986 1171-1175 PR_EXT:000017653 denotes Fog2
T987 1199-1208 UBERON:0001103 denotes diaphragm
T988 1213-1217 UBERON:0002048 denotes lung
T989 1213-1229 GO:0030324 denotes lung development
T990 1280-1284 PR_EXT:000017653 denotes FOG2
T991 1298-1302 SO_EXT:0000704 denotes gene
T992 1350-1355 NCBITaxon:9606 denotes human
T993 1367-1380 UBERON:0001103 denotes diaphragmatic
T994 1412-1421 UBERON:0002048 denotes pulmonary
T995 1412-1433 GO:0030324 denotes pulmonary development
T996 1464-1472 PATO_UBERON_EXT:neonate_or_newborn denotes neonates
T997 1489-1502 UBERON:0001103 denotes diaphragmatic
T998 1532-1541 UBERON:0002048 denotes pulmonary
T999 1532-1555 GO:0030324 denotes pulmonary developmental
T2495 3038-3051 UBERON:0001103 denotes diaphragmatic
T2497 3184-3197 UBERON:0001103 denotes diaphragmatic
T2498 3293-3306 UBERON:0001103 denotes diaphragmatic
T2499 3328-3333 GO:0007567 denotes birth
T2500 3335-3348 UBERON:0001103 denotes diaphragmatic
T2501 3361-3374 UBERON:0001103 denotes diaphragmatic
T2502 3375-3390 GO_EXT:muscle_structure_or_tissue_development denotes muscularization
T2503 3472-3480 UBERON:0001062 denotes anatomic
T2504 3584-3590 GO:0016265 denotes mortem
T2505 3605-3614 UBERON:0002048 denotes Pulmonary
T2506 3648-3661 UBERON:0001103 denotes diaphragmatic
T2507 3765-3778 UBERON:0001103 denotes diaphragmatic
T2508 3791-3800 UBERON:0002048 denotes pulmonary
T2509 3878-3887 UBERON:0002048 denotes pulmonary
T2510 4123-4129 GO:0016265 denotes deaths
T2511 4139-4144 GO:0007567 denotes birth
T2512 4151-4159 GO_EXT:biological_movement_or_translocation_process denotes transfer
T2513 4240-4251 UBERON:0001004 denotes respiratory
T2514 4263-4268 GO:0007567 denotes birth
T2515 4388-4392 UBERON:0002048 denotes lung
T2516 4406-4415 UBERON_EXT:body denotes corporeal
T2517 4425-4436 GO:0015671 denotes oxygenation
T2518 4501-4516 UBERON_EXT:heart_or_lung denotes cardiopulmonary
T2519 4695-4706 UBERON:0001004 denotes respiratory
T2520 4722-4731 GO:0050890 denotes cognitive
T2521 4736-4746 GO:0050905 denotes neuromotor
T2522 4761-4768 GO:0007605 denotes hearing
T2523 4939-4948 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T2524 4990-5003 UBERON:0001103 denotes diaphragmatic
T2525 5016-5025 UBERON:0002048 denotes pulmonary
T2526 5040-5046 NCBITaxon:9606 denotes humans
T2527 5199-5206 SO_EXT:0000704 denotes genetic
T2528 5277-5286 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T2529 5311-5320 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T2530 5357-5370 UBERON:0001103 denotes diaphragmatic
T2531 5357-5382 GO:0060539 denotes diaphragmatic development
T2532 5441-5452 GO_SO_EXT:chromosome denotes chromosomal
T2533 5536-5542 GO_EXT:fatality_or_lethality denotes lethal
T2534 5574-5580 NCBITaxon:9606 denotes humans
T2535 5626-5632 NCBITaxon:33208 denotes animal
T2536 5643-5648 NCBITaxon:9606 denotes human
T2537 5649-5654 GO:0007567 denotes birth
T2538 5680-5687 SO_EXT:0000704 denotes genetic
T2539 5711-5717 NCBITaxon:33208 denotes animal
T2540 5753-5758 NCBITaxon:9606 denotes human
T2541 5784-5788 NCBITaxon:10088 denotes mice
T2542 5806-5814 CHEBI_EXT:chemical_substance_or_polyatomic_entity denotes chemical
T2543 5815-5822 CHEBI_EXT:25435 denotes mutagen
T2544 5823-5844 CHEBI:23995 denotes N-ethyl-N-nitrosourea
T2545 5846-5849 CHEBI:23995 denotes ENU
T2546 5908-5924 UBERON:0012101 denotes perinatal period
T2547 5912-5917 GO:0007567 denotes natal
T2548 5973-5977 NCBITaxon:10088 denotes mice
T2549 5999-6007 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T2550 6032-6041 UBERON:0002048 denotes pulmonary
T2551 6066-6079 UBERON:0001103 denotes diaphragmatic
T2552 6066-6079 _FRAGMENT denotes diaphragmatic
T2553 6092-6103 GO:0060539 denotes development
T2554 6084-6091 UBERON:0000948 denotes cardiac
T2555 6084-6103 GO:0007507 denotes cardiac development
T2556 6116-6123 SO_EXT:sequence_cloning_process denotes cloning
T2557 6144-6148 PR_EXT:000017653 denotes Fog2
T2558 6150-6155 PR_EXT:000017653 denotes Zfpm2
T2559 6184-6187 CHEBI_SO_EXT:DNA denotes DNA
T2560 6210-6218 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T2561 6224-6230 GO:0008380 denotes splice
T2562 6224-6241 SO_EXT:splice_donor denotes splice donor site
T2563 6269-6279 SO_EXT:0000673 denotes transcript
T2564 6280-6288 SO_EXT:sequence_coding_function denotes encoding
T2565 6291-6300 SO_EXT:sequence_truncation_process denotes truncated
T2566 6301-6308 CHEBI_PR_EXT:protein denotes protein
T2567 6352-6363 SO:0000858 denotes orthologous
T2568 6364-6368 SO_EXT:0000704 denotes gene
T2569 6372-6378 NCBITaxon:9606 denotes humans
T2570 6454-6462 SO_EXT:nonsense_quality_or_entity denotes nonsense
T2571 6463-6471 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T2572 6475-6479 PR_EXT:000017653 denotes FOG2
T2573 6497-6501 GO:0016265 denotes died
T2574 6505-6510 GO:0007567 denotes birth
T2575 6518-6531 UBERON:0001103 denotes diaphragmatic
T2576 6550-6559 UBERON:0002048 denotes pulmonary
T2577 6599-6607 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T2578 6649-6654 NCBITaxon:9606 denotes human
T2579 6717-6726 UBERON:0002048 denotes pulmonary
T5179 6835-6839 UBERON:0002048 denotes lung
T5180 6840-6848 SO_EXT:sequence_alteration_entity_or_process denotes Mutation
T5181 6852-6856 PR_EXT:000017653 denotes Fog2
T5182 6897-6900 CHEBI:23995 denotes ENU
T5183 6913-6917 NCBITaxon:10088 denotes mice
T5184 6921-6930 UBERON:0000922 denotes embryonic
T5185 7004-7008 NCBITaxon:10088 denotes mice
T5186 7036-7043 UBERON:0000922 denotes embryos
T5187 7082-7091 UBERON:0002048 denotes pulmonary
T5188 7114-7123 UBERON:0001103 denotes diaphragm
T5189 7129-7137 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5190 7162-7166 UBERON:0002048 denotes lung
T5191 7188-7198 GO_SO_EXT:chromosome denotes Chromosome
T5192 7238-7247 SO_EXT:0001024 denotes haplotype
T5193 7408-7409 SO_EXT:normal_or_wild_type_or_present denotes +
T5194 7410-7414 NCBITaxon:10088 denotes mice
T5195 7444-7452 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5196 7471-7483 SO_EXT:sequence_recombinant_entity denotes recombinants
T5197 7552-7559 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T5198 7678-7690 SO_EXT:sequence_recombinant_entity denotes recombinants
T5199 7754-7762 SO:0000357 denotes flanking
T5200 7763-7770 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T5201 7832-7841 UBERON:0002048 denotes pulmonary
T5202 7869-7878 UBERON:0001103 denotes diaphragm
T5203 7880-7889 UBERON:0002048 denotes Pulmonary
T5204 7921-7927 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5205 7928-7932 NCBITaxon:10088 denotes mice
T5206 7950-7955 GO:0007567 denotes birth
T5207 7981-7990 SO_EXT:wild_type_entity_or_quality denotes wild-type
T5208 7995-8001 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5209 8002-8006 NCBITaxon:10088 denotes mice
T5210 8032-8036 UBERON:0000104 denotes life
T5211 8038-8042 UBERON_EXT:body denotes body
T5212 8084-8088 UBERON:0002048 denotes lung
T5213 8129-8135 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5214 8136-8140 NCBITaxon:10088 denotes mice
T5215 8154-8160 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5216 8161-8165 UBERON:0002048 denotes lung
T5217 8208-8217 SO_EXT:wild_type_entity_or_quality denotes wild-type
T5218 8218-8222 UBERON:0002048 denotes lung
T5219 8265-8270 UBERON:0002048 denotes lungs
T5220 8276-8282 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5221 8283-8287 NCBITaxon:10088 denotes mice
T5222 8314-8318 UBERON:0009912 denotes lobe
T5223 8391-8395 UBERON:0009912 denotes lobe
T5224 8409-8419 UBERON:0001103 denotes Diaphragms
T5225 8425-8431 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5226 8436-8440 NCBITaxon:10088 denotes mice
T5227 8458-8473 GO_EXT:muscle_structure_or_tissue_development denotes muscularization
T5228 8508-8518 CL:0002372 denotes Myotubules
T5229 8591-8601 CL:0002372 denotes myotubules
T5230 8665-8675 UBERON:0000309 denotes body walls
T5231 8702-8708 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T5232 8702-8715 CL:0000187 denotes muscle fibers
T5233 8723-8740 UBERON:0006670 denotes central tendonous
T5234 8756-8762 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5235 8763-8772 UBERON:0001103 denotes diaphragm
T5236 8774-8784 CL:0002372 denotes myotubules
T5237 8831-8844 UBERON:0002385 denotes muscle tissue
T5238 8884-8894 UBERON:0000309 denotes body walls
T5239 9382-9388 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5240 9389-9393 NCBITaxon:10088 denotes mice
T5241 9411-9416 GO:0007567 denotes birth
T5242 9497-9505 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5243 9541-9550 UBERON:0000922 denotes embryonic
T5244 9620-9627 UBERON:0000995 denotes uterine
T5245 9628-9634 GO:0016265 denotes demise
T5246 9701-9708 UBERON:0000922 denotes embryos
T5247 9760-9767 UBERON:0000995 denotes uterine
T5248 9768-9774 GO:0016265 denotes demise
T5249 9786-9792 GO_EXT:biological_growth_entity_or_process denotes growth
T5250 9818-9824 UBERON:0000479 denotes tissue
T5251 9841-9848 UBERON:0000922 denotes embryos
T5252 9884-9890 GO:0016265 denotes demise
T5253 9969-9977 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5254 10043-10049 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5255 10062-10066 GO:0016265 denotes died
T5256 10102-10108 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5257 10129-10135 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5258 10136-10143 UBERON:0000922 denotes embryos
T5259 10167-10171 GO:0016265 denotes died
T5260 10194-10201 UBERON:0000922 denotes embryos
T5261 10232-10240 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5262 10260-10266 UBERON:0000922 denotes embryo
T5263 10279-10292 UBERON:0001103 denotes Diaphragmatic
T5264 10293-10308 GO_EXT:muscle_structure_or_tissue_development denotes muscularization
T5265 10329-10335 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5266 10336-10340 NCBITaxon:10088 denotes mice
T5267 10360-10369 UBERON:0002048 denotes Pulmonary
T5268 10405-10412 SO_EXT:sequence_altered_entity denotes mutants
T5269 10460-10465 GO:0007567 denotes birth
T5270 10491-10498 UBERON:0000948 denotes cardiac
T5271 10522-10528 UBERON:0000948 denotes hearts
T5272 10544-10550 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5273 10551-10555 NCBITaxon:10088 denotes mice
T5274 10640-10660 UBERON:0002062 denotes endocardial cushions
T5275 10671-10677 UBERON:0004145 denotes outlet
T5276 10678-10693 UBERON:0002080 denotes right ventricle
T5277 10710-10732 UBERON:0002087 denotes atrioventricular canal
T5278 10738-10748 UBERON:0002349 denotes myocardium
T5279 10803-10816 UBERON:0004125 denotes compact layer
T5280 10858-10864 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5281 10865-10869 NCBITaxon:10088 denotes mice
T5282 10887-10892 GO:0007567 denotes birth
T5283 10902-10909 UBERON:0000948 denotes cardiac
T5284 10934-10956 UBERON:0002087 denotes atrioventricular-canal
T5285 10962-10980 UBERON:0002094 denotes ventricular septal
T5286 10990-11003 UBERON:0009149 denotes ostium primum
T5287 11004-11017 UBERON:0002085 denotes atrial septal
T5288 11040-11045 UBERON:0002081 denotes atria
T5289 11068-11075 SO_EXT:sequence_altered_entity denotes mutants
T5290 11105-11112 UBERON:0000948 denotes cardiac
T5291 11145-11152 UBERON:0000948 denotes cardiac
T5292 11145-11164 GO:0007507 denotes cardiac development
T5293 11188-11189 CHEBI_SO_EXT:base denotes b
T5294 11229-11232 CHEBI_SO_EXT:DNA denotes DNA
T5295 11233-11241 SO_EXT:biological_sequence denotes sequence
T5296 11267-11282 SO_EXT:0000996 denotes predicted genes
T5297 11298-11303 SO_EXT:0000704 denotes genes
T5298 11315-11319 PR_EXT:000017653 denotes Fog2
T5299 11330-11339 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T5300 11343-11347 PR_EXT:000017653 denotes Fog2
T5301 11353-11360 UBERON:0000948 denotes cardiac
T5302 11418-11424 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5303 11425-11429 NCBITaxon:10088 denotes mice
T5304 11441-11463 UBERON:0002087 denotes atrioventricular canal
T5305 11481-11491 UBERON:0002349 denotes myocardium
T5306 11504-11512 UBERON:0005985 denotes coronary
T5307 11513-11524 UBERON:0002049 denotes vasculature
T5308 11531-11533 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T5309 11579-11583 PR_EXT:000017653 denotes Fog2
T5310 11600-11611 SO_EXT:0000673 denotes transcripts
T5311 11623-11629 SO_EXT:sequence_altered_entity denotes mutant
T5312 11642-11651 SO_EXT:wild_type_entity_or_quality denotes wild-type
T5313 11652-11659 UBERON:0000922 denotes embryos
T5314 11691-11697 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5315 11698-11708 SO_EXT:0000673 denotes transcript
T5316 11720-11734 SO_EXT:point_mutation_entity_or_process denotes point mutation
T5317 11741-11748 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T5318 11752-11760 CHEBI_EXT:cytosine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes cytosine
T5319 11764-11766 SO_EXT:0000028 denotes bp
T5320 11803-11809 GO:0008380 denotes splice
T5321 11803-11820 SO_EXT:splice_donor denotes splice donor site
T5322 11845-11849 SO_EXT:0000147 denotes exon
T5323 11856-11864 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5324 11874-11882 GO:0008380 denotes splicing
T5325 11910-11919 SO_EXT:sequence_insertion_entity_or_process denotes insertion
T5326 11926-11928 SO_EXT:0000028 denotes bp
T5327 11932-11940 SO_EXT:0000188 denotes intronic
T5328 11941-11949 SO_EXT:biological_sequence denotes sequence
T5329 11959-11965 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5330 11966-11976 SO_EXT:0000673 denotes transcript
T5331 11995-12005 SO_EXT:0000319 denotes stop codon
T5332 12032-12041 SO_EXT:sequence_truncation_process denotes truncated
T5333 12042-12049 CHEBI_PR_EXT:protein denotes protein
T5334 12088-12094 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T5335 12095-12099 NCBITaxon:10088 denotes mice
T5336 12120-12124 PR_EXT:000017653 denotes Fog2
T5337 12125-12126 SO_EXT:normal_or_wild_type_or_present denotes +
T5338 12127-12128 SO_EXT:sequence_nullness_or_absence denotes −
T5339 12130-12134 SO_EXT:sequence_nullness denotes null
T5340 12135-12141 SO_EXT:0001023 denotes allele
T5341 12143-12149 SO_EXT:sequence_altered_entity denotes mutant
T5342 12163-12167 SO_EXT:0000704 denotes gene
T5343 12204-12208 NCBITaxon:10088 denotes mice
T5344 12216-12225 UBERON:0000922 denotes embryonic
T5345 12226-12232 GO_EXT:fatality_or_lethality denotes lethal
T5346 12292-12300 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5347 12304-12308 PR_EXT:000017653 denotes Fog2
T5348 12340-12344 NCBITaxon:10088 denotes mice
T5349 12377-12381 PR_EXT:000017653 denotes Fog2
T5350 12382-12386 SO_EXT:sequence_nullness denotes null
T5351 12387-12393 SO_EXT:sequence_altered_entity denotes mutant
T5352 12452-12462 SO_EXT:0000673 denotes transcript
T5353 12491-12497 GO:0008380 denotes splice
T5354 12491-12502 SO_EXT:0000162 denotes splice site
T5355 12503-12511 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T7954 12938-12942 UBERON:0002048 denotes Lung
T7955 12938-12942 _FRAGMENT denotes Lung
T7956 12957-12968 GO:0030324 denotes Development
T7957 12947-12956 UBERON:0001103 denotes Diaphragm
T7958 12947-12968 GO:0060539 denotes Diaphragm Development
T7959 12976-12980 PR_EXT:000017653 denotes Fog2
T7960 12981-12987 SO_EXT:sequence_altered_entity_or_alteration_process denotes Mutant
T7961 12988-12993 NCBITaxon:10088 denotes Mouse
T7962 13045-13049 PR_EXT:000017653 denotes Fog2
T7963 13053-13062 UBERON:0002048 denotes pulmonary
T7964 13053-13062 _FRAGMENT denotes pulmonary
T7965 13081-13092 GO:0030324 denotes development
T7966 13067-13080 UBERON:0001103 denotes diaphragmatic
T7967 13067-13092 GO:0060539 denotes diaphragmatic development
T7968 13098-13107 UBERON:0002048 denotes pulmonary
T7969 13192-13196 UBERON:0009912 denotes lobe
T7970 13231-13235 UBERON:0009912 denotes lobe
T7971 13289-13302 UBERON:0001103 denotes diaphragmatic
T7972 13289-13314 GO:0060539 denotes diaphragmatic development
T7973 13360-13369 UBERON:0002048 denotes pulmonary
T7974 13467-13471 PR_EXT:000017653 denotes Fog2
T7975 13475-13484 GO:0010467 denotes expressed
T7976 13502-13522 UBERON:0004883 denotes pulmonary mesenchyme
T7977 13544-13567 GO:0001763 denotes branching morphogenesis
T7978 13581-13591 GO:0010467 denotes expression
T7979 13613-13627 UBERON:0001135 denotes smooth muscles
T7980 13631-13638 UBERON:0001005 denotes airways
T7981 13643-13652 UBERON:0002048 denotes pulmonary
T7982 13653-13660 UBERON:0000055 denotes vessels
T7983 13704-13709 UBERON:0002048 denotes lungs
T7984 13767-13780 UBERON:0001103 denotes diaphragmatic
T7985 13781-13796 GO_EXT:muscle_structure_or_tissue_development denotes muscularization
T7986 13828-13837 UBERON:0002048 denotes pulmonary
T7987 13877-13890 UBERON:0001103 denotes diaphragmatic
T7988 13924-13929 UBERON:0002048 denotes lungs
T7989 13950-13954 PR_EXT:000017653 denotes Fog2
T7990 13955-13956 SO_EXT:sequence_nullness_or_absence denotes −
T7991 13957-13958 SO_EXT:sequence_nullness_or_absence denotes −
T7992 13959-13963 NCBITaxon:10088 denotes mice
T7993 14014-14027 UBERON:0001103 denotes diaphragmatic
T7994 14028-14034 GO_EXT:biological_movement_or_translocation_process denotes motion
T7995 14036-14040 PR_EXT:000017653 denotes Fog2
T7996 14041-14042 SO_EXT:sequence_nullness_or_absence denotes −
T7997 14043-14044 SO_EXT:sequence_nullness_or_absence denotes −
T7998 14045-14049 NCBITaxon:10088 denotes mice
T7999 14158-14166 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T8000 14168-14173 UBERON:0002048 denotes Lungs
T8001 14196-14200 PR_EXT:000017653 denotes Fog2
T8002 14201-14202 SO_EXT:sequence_nullness_or_absence denotes −
T8003 14203-14204 SO_EXT:sequence_nullness_or_absence denotes −
T8004 14205-14212 UBERON:0000922 denotes embryos
T8005 14277-14281 UBERON:0009912 denotes lobe
T8006 14296-14300 PR_EXT:000017653 denotes Fog2
T8007 14300-14301 SO_EXT:sequence_nullness_or_absence denotes −
T8008 14303-14304 SO_EXT:sequence_nullness_or_absence denotes −
T8010 14372-14376 UBERON:0009912 denotes lobe
T8011 14397-14403 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T8012 14404-14409 UBERON:0002048 denotes lungs
T8013 14530-14539 UBERON:0002048 denotes pulmonary
T8014 14554-14558 PR_EXT:000017653 denotes Fog2
T8015 14559-14565 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T8016 14566-14570 NCBITaxon:10088 denotes mice
T8017 15232-15237 UBERON:0009912 denotes lobes
T8018 15280-15287 SO_EXT:sequence_altered_entity denotes mutants
T8019 15347-15352 UBERON:0009912 denotes lobes
T8020 15388-15392 PR_EXT:000017653 denotes Fog2
T8021 15428-15433 UBERON:0009912 denotes lobar
T8022 15463-15467 PR_EXT:000017653 denotes Fog2
T8023 15468-15478 GO:0010467 denotes expression
T8024 15503-15510 UBERON:0000922 denotes embryos
T8025 15538-15543 UBERON:0009912 denotes lobar
T8026 15579-15583 PR_EXT:000017653 denotes Fog2
T8027 15584-15594 GO:0010467 denotes expression
T8028 15630-15635 UBERON:0009912 denotes lobar
T8029 15642-15652 GO:0010467 denotes Expression
T8030 15670-15674 NCBITaxon:10088 denotes mice
T8031 15686-15690 PR_EXT:000033987 denotes lacZ
T8032 15691-15695 SO_EXT:0000704 denotes gene
T8033 15718-15722 PR_EXT:000017653 denotes Fog2
T8034 15770-15774 NCBITaxon:10088 denotes mice
T8035 15798-15803 UBERON:0002048 denotes lungs
T8036 15837-15841 PR_EXT:000017653 denotes Fog2
T8037 15842-15852 GO:0010467 denotes expression
T8038 15860-15870 UBERON:0003104 denotes mesenchyme
T8039 15922-15926 UBERON:0009912 denotes lobe
T8040 15946-15951 UBERON:0009912 denotes lobes
T8041 15984-15988 PR_EXT:000017653 denotes Fog2
T8042 15989-15995 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T8043 15996-16000 NCBITaxon:10088 denotes mice
T8044 16023-16033 GO:0010467 denotes expression
T8045 16053-16073 UBERON:0004883 denotes pulmonary mesenchyme
T8046 16111-16124 GO:0097617 denotes hybridization
T8047 16128-16134 UBERON:0000479 denotes tissue
T8048 16419-16429 UBERON:0001103 denotes Diaphragms
T8049 16435-16439 PR_EXT:000017653 denotes Fog2
T8050 16444-16448 NCBITaxon:10088 denotes mice
T8051 16490-16498 UBERON_EXT:muscle_structure_or_tissue denotes muscular
T8052 16499-16509 GO_PATO_EXT:biological_patterning_process_or_quality denotes patterning
T8053 16557-16566 UBERON:0001103 denotes diaphragm
T8054 16585-16594 GO_EXT:biological_movement_or_translocation_process denotes migratory
T8055 16595-16608 _FRAGMENT denotes population of
T8056 16626-16631 UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population denotes cells
T8057 16609-16615 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T8058 16609-16631 CL:0000680 denotes muscle precursor cells
T8059 16626-16631 CL_GO_EXT:cell denotes cells
T8060 16647-16652 UBERON:0002101 denotes limbs
T8061 16662-16666 NCBITaxon:10088 denotes Mice
T8062 16683-16688 SO_EXT:0000704 denotes genes
T8063 16719-16726 GO:0065007 denotes control
T8064 16760-16768 UBERON_EXT:muscle_structure_or_tissue denotes muscular
T8065 16769-16779 UBERON:0001103 denotes diaphragms
T8066 16792-16802 CL:0000182 denotes Hepatocyte
T8067 16792-16816 PR_EXT:000008534 denotes Hepatocyte growth factor
T8068 16803-16809 GO_EXT:biological_growth_entity_or_process denotes growth
T8069 16803-16816 GO_EXT:0008083 denotes growth factor
T8070 16817-16831 PR_EXT:000008534 denotes Scatter factor
T8071 16833-16836 PR_EXT:000008534 denotes HGF
T8072 16885-16893 GO_EXT:biological_direction_or_guidance denotes guidance
T8073 16897-16903 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T8074 16933-16942 UBERON:0001103 denotes diaphragm
T8075 16967-16970 PR_EXT:000008534 denotes HGF
T8076 16974-16983 GO:0010467 denotes expressed
T8077 16995-17003 UBERON:0001062 denotes anatomic
T8078 17022-17026 NCBITaxon:10088 denotes mice
T8079 17047-17059 GO_PR_EXT:hepatocyte_growth_factor_receptor denotes HGF receptor
T8080 17060-17065 PR_EXT:000010335 denotes c-Met
T8081 17079-17091 GO_EXT:muscle_structure_or_tissue_development denotes muscularized
T8082 17092-17114 UBERON:0009133 denotes pleuroperitoneal folds
T8083 17116-17120 UBERON:0009133 denotes PPFs
T8084 17138-17146 UBERON_EXT:muscle_structure_or_tissue denotes muscular
T8085 17147-17157 UBERON:0001103 denotes diaphragms
T8086 17167-17171 PR_EXT:000017653 denotes Fog2
T8087 17175-17184 GO:0010467 denotes expressed
T8088 17209-17217 UBERON_EXT:muscle_structure_or_tissue denotes muscular
T8089 17218-17227 UBERON:0001103 denotes diaphragm
T8090 17261-17273 GO_EXT:muscle_structure_or_tissue_development denotes muscularized
T8091 17274-17283 UBERON:0001103 denotes diaphragm
T8092 17308-17312 PR_EXT:000012316 denotes Pax3
T8093 17317-17321 PR_EXT:000010875 denotes MyoD
T8094 17323-17336 GO_EXT:transcription denotes transcription
T8095 17323-17344 GO_EXT:transcription_factor denotes transcription factors
T8096 17370-17379 GO_EXT:biological_movement_or_translocation_process denotes migration
T8097 17401-17409 GO_EXT:muscle_structure_or_tissue_development denotes myogenic
T8098 17443-17447 UBERON:0009133 denotes PPFs
T8099 17451-17455 PR_EXT:000017653 denotes Fog2
T8100 17460-17464 NCBITaxon:10088 denotes mice
T8101 17500-17510 GO:0010467 denotes expression
T8102 17542-17552 GO:0010467 denotes expression
T8103 17556-17559 PR_EXT:000008534 denotes HGF
T8104 17616-17625 UBERON:0001103 denotes diaphragm
T8105 17650-17654 PR_EXT:000017653 denotes Fog2
T8106 17655-17661 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T8107 17662-17666 NCBITaxon:10088 denotes mice
T8108 17699-17703 PR_EXT:000017653 denotes Fog2
T8109 17769-17772 PR_EXT:000008534 denotes HGF
T8110 17791-17800 UBERON:0001103 denotes diaphragm
T8111 17809-17819 GO:0065007 denotes regulation
T8112 17823-17826 PR_EXT:000008534 denotes HGF
T8113 17827-17837 GO_PATO_EXT:biological_patterning_process_or_quality denotes patterning
T8114 17856-17862 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T8115 17856-17877 CL:0000680 denotes muscle precursor cell
T8116 17873-17877 CL_GO_EXT:cell denotes cell
T8117 17873-17887 GO:0016477 denotes cell migration
T8118 17900-17903 UBERON:0009133 denotes PPF
T8119 17912-17921 UBERON:0001103 denotes diaphragm
T8120 17967-17971 NCBITaxon:10088 denotes mice
T9833 18221-18225 PR_EXT:000017653 denotes FOG2
T9834 18226-18234 SO_EXT:sequence_alteration_entity_or_process denotes Mutation
T9835 18253-18262 UBERON:0001103 denotes Diaphragm
T9836 18267-18271 UBERON:0002048 denotes Lung
T9837 18286-18290 PR_EXT:000017653 denotes FOG2
T9838 18291-18299 SO_EXT:biological_sequence denotes sequence
T9839 18334-18340 UBERON:0000479 denotes tissue
T9840 18364-18372 NCBITaxon_UBERON_EXT:child denotes children
T9841 18381-18389 UBERON:0001062 denotes anatomic
T9842 18403-18416 UBERON:0001103 denotes diaphragmatic
T9843 18441-18449 NCBITaxon_UBERON_EXT:child denotes Children
T9844 18637-18650 UBERON:0001103 denotes diaphragmatic
T9845 18677-18690 UBERON:0001103 denotes diaphragmatic
T9846 18703-18718 GO_EXT:muscle_structure_or_tissue_development denotes muscularization
T9847 18839-18848 UBERON:0002048 denotes Pulmonary
T9848 18879-18883 UBERON:0002048 denotes lung
T9849 18884-18888 UBERON_EXT:body denotes body
T9850 18913-18921 UBERON:0003215 denotes alveolar
T9851 19077-19082 NCBITaxon_UBERON_EXT:child denotes child
T9852 19112-19116 PR_EXT:000017653 denotes FOG2
T9853 19117-19125 SO_EXT:biological_sequence denotes sequence
T9854 19126-19132 SO_EXT:sequence_alteration_entity_or_process denotes change
T9855 19170-19174 UBERON_EXT:baby_or_infant denotes baby
T9856 19175-19179 NCBITaxon_UBERON_EXT:girl denotes girl
T9857 19201-19212 UBERON:0001004 denotes respiratory
T9858 19224-19229 GO:0007567 denotes birth
T9859 19234-19238 GO:0016265 denotes died
T9860 19271-19277 GO:0016265 denotes mortem
T9861 19307-19311 UBERON:0002048 denotes lung
T9862 19332-19337 UBERON:0000160 denotes bowel
T9863 19345-19350 UBERON:0001443 denotes chest
T9864 19447-19456 UBERON:0002048 denotes pulmonary
T9865 19478-19482 UBERON:0002048 denotes lung
T9866 19512-19516 UBERON_EXT:body denotes body
T9867 19582-19591 UBERON:0002168 denotes left lung
T9868 19597-19601 UBERON:0002048 denotes lung
T9869 19602-19606 UBERON_EXT:body denotes body
T9870 19687-19696 UBERON_EXT:bronchiole_or_bronchus denotes bronchial
T9871 19725-19733 UBERON:0003215 denotes alveolar
T9872 19791-19795 UBERON:0002048 denotes lung
T9873 19835-19848 UBERON:0001103 denotes diaphragmatic
T9874 19909-19921 GO_EXT:muscle_structure_or_tissue_development denotes muscularized
T9875 19922-19933 UBERON:0000211 denotes ligamentous
T9876 19951-19964 UBERON:0001103 denotes diaphragmatic
T9877 19988-20000 _FRAGMENT denotes left lobe of
T9878 20005-20010 UBERON:0001115 denotes liver
T9879 20042-20047 UBERON:0002107 denotes liver
T9880 20088-20097 UBERON:0001103 denotes diaphragm
T9881 20112-20124 GO_EXT:muscle_structure_or_tissue_development denotes muscularized
T9882 20213-20218 UBERON:0000948 denotes heart
T9883 20275-20280 UBERON:0003978 denotes valve
T9884 20290-20298 SO_EXT:biological_sequence denotes Sequence
T9885 20319-20327 CHEBI_EXT:cytosine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes cytosine
T9886 20331-20338 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T9887 20352-20358 SO_EXT:sequence_alteration_entity_or_process denotes change
T9888 20362-20366 SO_EXT:0000147 denotes exon
T9889 20374-20381 SO_EXT:sequence_alteration_process denotes changes
T9890 20392-20402 CHEBI_SO_EXT:amino_acid denotes amino acid
T9891 20408-20416 CHEBI_SO_EXT:arginine denotes arginine
T9892 20422-20432 SO_EXT:0000319 denotes stop codon
T9893 20439-20447 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T9894 20468-20477 SO_EXT:sequence_truncation_process denotes truncated
T9895 20478-20485 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptide
T9896 20508-20512 CHEBI_EXT:zinc denotes zinc
T9897 20520-20527 SO_EXT:0000417 denotes domains
T9898 20545-20549 CHEBI_SO_EXT:base denotes base
T9899 20550-20556 SO_EXT:sequence_alteration_entity_or_process denotes change
T9900 20592-20595 CHEBI_SO_EXT:DNA denotes DNA
T9901 20612-20618 UBERON:0007023 denotes adults
T9902 20654-20662 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T9903 20762-20770 SO_EXT:biological_sequence denotes sequence
T9904 20826-20834 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T9905 20875-20883 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T9906 20887-20891 PR_EXT:000017653 denotes FOG2
T12833 21289-21302 UBERON:0001103 denotes diaphragmatic
T12834 21411-21427 UBERON:0012101 denotes perinatal period
T12835 21415-21420 GO:0007567 denotes natal
T12836 21454-21467 UBERON:0001103 denotes diaphragmatic
T12837 21500-21515 GO_EXT:muscle_structure_or_tissue_development denotes muscularization
T12838 21800-21809 UBERON:0001103 denotes diaphragm
T12839 21815-21830 GO_EXT:muscle_structure_or_tissue_development denotes muscularization
T12840 21882-21887 GO:0007567 denotes natal
T12841 21906-21911 GO:0007567 denotes natal
T12842 21912-21917 UBERON:0001443 denotes chest
T12843 21945-21958 UBERON:0001103 denotes diaphragmatic
T12844 21959-21974 GO_EXT:muscle_structure_or_tissue_development denotes muscularization
T12845 22122-22130 PATO_UBERON_EXT:neonate_or_newborn denotes neonatal
T12846 22346-22355 UBERON:0000916 denotes abdominal
T12847 22386-22395 UBERON:0002048 denotes pulmonary
T12848 22411-22422 UBERON:0001004 denotes respiratory
T12849 22455-22465 GO_SO_EXT:chromosome denotes chromosome
T12850 22527-22536 UBERON:0001103 denotes diaphragm
T12851 22560-22565 NCBITaxon:9606 denotes Human
T12852 22566-22570 PR_EXT:000017653 denotes FOG2
T12853 22579-22589 GO_SO_EXT:chromosome denotes Chromosome
T12854 22638-22647 UBERON:0001103 denotes diaphragm
T12855 22660-22674 GO_SO_EXT:sequence_rearrangement_entity_or_process denotes rearrangements
T12856 22799-22813 GO_EXT:biological_translocation_entity_or_process denotes translocations
T12857 22829-22833 PR_EXT:000017653 denotes FOG2
T12858 22881-22890 SO_EXT:sequence_deletion_entity_or_process denotes deletions
T12859 22919-22923 PR_EXT:000017653 denotes FOG2
T12860 22935-22939 GO:0016265 denotes died
T12861 23019-23023 SO_EXT:0000704 denotes gene
T12862 23031-23042 GO_SO_EXT:chromosome denotes chromosomal
T12863 23043-23056 GO_SO_EXT:sequence_rearrangement_entity_or_process denotes rearrangement
T12864 23060-23068 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T12865 23100-23104 SO_EXT:sequence_nullness denotes null
T12866 23105-23113 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T12867 23174-23178 PR_EXT:000017653 denotes FOG2
T12868 23179-23187 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T12869 23235-23244 UBERON:0002048 denotes pulmonary
T12870 23249-23262 UBERON:0001103 denotes diaphragmatic
T12871 23291-23296 NCBITaxon:10088 denotes mouse
T12872 23301-23306 NCBITaxon:9606 denotes human
T12873 23329-23337 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T12874 23341-23345 PR_EXT:000017653 denotes FOG2
T12875 23379-23384 NCBITaxon:9606 denotes human
T12876 23399-23412 UBERON:0001103 denotes diaphragmatic
T12877 23417-23426 UBERON:0002048 denotes pulmonary
T12878 23463-23468 NCBITaxon_UBERON_EXT:child denotes child
T12879 23470-23474 NCBITaxon:10088 denotes mice
T12880 23494-23498 SO_EXT:sequence_nullness denotes null
T12881 23499-23507 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T12882 23511-23515 PR_EXT:000017653 denotes Fog2
T12883 23614-23618 SO_EXT:0000704 denotes gene
T12884 23679-23685 NCBITaxon:9606 denotes humans
T12885 23691-23695 NCBITaxon:10088 denotes mice
T12886 23724-23728 PR_EXT:000017653 denotes Fog2
T12887 23729-23742 UBERON:0001103 denotes diaphragmatic
T12888 23851-23857 UBERON_EXT:muscle_structure_or_tissue denotes Muscle
T12889 23894-23903 UBERON:0001103 denotes diaphragm
T12890 23904-23911 GO_EXT:biological_movement_or_translocation_process denotes migrate
T12891 23929-23941 UBERON:0004290 denotes dermomyotome
T12892 23945-23953 UBERON:0005434 denotes cervical
T12893 23954-23961 UBERON:0002329 denotes somites
T12894 23972-23981 GO_EXT:biological_movement_or_translocation_process denotes migration
T12895 23991-24000 UBERON:0001103 denotes diaphragm
T12896 24020-24023 UBERON:0009133 denotes PPF
T12897 24040-24046 UBERON:0000479 denotes tissue
T12898 24085-24094 UBERON:0000309 denotes body wall
T12899 24102-24122 UBERON:0003283 denotes esophageal mesentery
T12900 24152-24170 UBERON:0004161 denotes septum transversum
T12901 24177-24183 UBERON_EXT:muscle_structure_or_tissue denotes Muscle
T12902 24205-24208 UBERON:0009133 denotes PPF
T12903 24228-24239 GO:0008283 denotes proliferate
T12904 24241-24254 GO_RO_EXT:developmental_differentiation_process denotes differentiate
T12905 24265-24272 GO_EXT:biological_movement_or_translocation_process denotes migrate
T12906 24297-24303 UBERON:0002228 denotes costal
T12907 24305-24312 UBERON:0000975 denotes sternal
T12908 24313-24319 UBERON:0002228 denotes costal
T12909 24325-24331 UBERON:0000978 denotes crural
T12910 24358-24367 UBERON:0001103 denotes diaphragm
T12911 24387-24390 UBERON:0009133 denotes PPF
T12912 24438-24450 _FRAGMENT denotes formation of
T12913 24455-24464 GO:0060539 denotes diaphragm
T12914 24455-24464 UBERON:0001103 denotes diaphragm
T12915 24494-24498 PR_EXT:000017653 denotes Fog2
T12916 24499-24505 SO_EXT:sequence_altered_entity denotes mutant
T12917 24539-24542 PR_EXT:000008534 denotes HGF
T12918 24543-24553 GO:0010467 denotes expression
T12919 24582-24588 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T12920 24582-24604 CL:0000680 denotes muscle precursor cells
T12921 24599-24604 CL_GO_EXT:cell denotes cells
T12922 24605-24612 GO_EXT:biological_movement_or_translocation_process denotes migrate
T12923 24633-24642 UBERON:0001103 denotes diaphragm
T12924 24688-24697 GO_PATO_EXT:biological_patterning_process_or_quality denotes patterned
T12925 24698-24704 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T12926 24726-24730 PR_EXT:000017653 denotes Fog2
T12927 24731-24737 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T12928 24738-24747 UBERON:0001103 denotes diaphragm
T12929 24758-24762 PR_EXT:000012316 denotes Pax3
T12930 24767-24771 PR_EXT:000010875 denotes MyoD
T12931 24772-24782 GO:0010467 denotes expression
T12932 24802-24805 UBERON:0009133 denotes PPF
T12933 24830-24843 GO_EXT:transcription denotes transcription
T12934 24830-24851 GO_EXT:transcription_factor denotes transcription factors
T12935 24868-24874 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T12936 24868-24889 CL:0000680 denotes muscle precursor cell
T12937 24885-24889 CL_GO_EXT:cell denotes cell
T12938 24885-24899 GO:0016477 denotes cell migration
T12939 24885-24889 _FRAGMENT denotes cell
T12940 24904-24919 GO:0030154 denotes differentiation
T12941 24958-24961 UBERON:0009133 denotes PPF
T12942 24987-24993 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T12943 24987-25008 CL:0000680 denotes muscle precursor cell
T12944 25004-25008 CL_GO_EXT:cell denotes cell
T12945 25004-25018 GO:0016477 denotes cell migration
T12946 25031-25034 UBERON:0009133 denotes PPF
T12947 25054-25063 UBERON:0001103 denotes diaphragm
T12948 25065-25069 PR_EXT:000017653 denotes Fog2
T12949 25113-25120 PR_EXT:000007857 denotes Gatas 1
T12950 25113-25118 _FRAGMENT denotes Gatas
T12951 25121-25122 PR_EXT:000007861 denotes 6
T12952 25141-25154 GO_EXT:transcription denotes transcription
T12953 25141-25162 GO_EXT:transcription_factor denotes transcription factors
T12954 25171-25179 PR_EXT:000011405 denotes CoupTFII
T12955 25208-25212 PR_EXT:000017653 denotes Fog2
T12956 25213-25218 PR_EXT:000007859 denotes Gata4
T12957 25254-25261 UBERON:0000948 denotes cardiac
T12958 25254-25261 _FRAGMENT denotes cardiac
T12959 25274-25285 GO:0007507 denotes development
T12960 25266-25273 UBERON:0000991 denotes gonadal
T12961 25266-25285 GO:0008406 denotes gonadal development
T12962 25318-25322 UBERON:0002048 denotes lung
T12963 25327-25336 UBERON:0001103 denotes diaphragm
T12964 25383-25392 UBERON:0002048 denotes pulmonary
T12965 25466-25475 UBERON:0001103 denotes diaphragm
T12966 25484-25493 UBERON:0002048 denotes Pulmonary
T12967 25533-25546 UBERON:0001103 denotes diaphragmatic
T12968 25547-25554 UBERON:0001062 denotes anatomy
T12969 25639-25652 UBERON:0001103 denotes diaphragmatic
T12970 25683-25698 GO_EXT:muscle_structure_or_tissue_development denotes muscularization
T12971 25707-25720 UBERON:0001884 denotes phrenic nerve
T12972 25830-25834 NCBITaxon:9940 denotes lamb
T12973 25882-25891 UBERON:0002048 denotes pulmonary
T12974 25882-25905 GO:0030324 denotes pulmonary developmental
T12975 25958-25971 UBERON:0001103 denotes diaphragmatic
T12976 26020-26031 CHEBI_EXT:50905 denotes teratogenic
T12977 26159-26164 UBERON:0009912 denotes lobar
T12978 26295-26304 UBERON:0002048 denotes pulmonary
T12979 26334-26338 NCBITaxon:10088 denotes mice
T12980 26348-26357 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T12981 26361-26365 PR_EXT:000017653 denotes Fog2
T12982 26407-26411 UBERON:0002048 denotes lung
T12983 26407-26423 GO:0030324 denotes lung development
T12984 26471-26475 UBERON:0009912 denotes lobe
T12985 26513-26517 UBERON:0009912 denotes lobe
T12986 26532-26537 UBERON:0009912 denotes lobar
T12987 26570-26574 PR_EXT:000017653 denotes Fog2
T12988 26575-26585 GO:0010467 denotes expression
T12989 26607-26612 UBERON:0009912 denotes lobar
T12990 26628-26632 PR_EXT:000017653 denotes Fog2
T12991 26633-26643 GO:0010467 denotes expression
T12992 26662-26682 UBERON:0004883 denotes pulmonary mesenchyme
T12993 26689-26694 UBERON:0009912 denotes lobar
T12994 26753-26762 GO:0010467 denotes expressed
T12995 26770-26780 UBERON:0003104 denotes mesenchyme
T12996 26810-26814 UBERON:0009912 denotes lobe
T12997 26843-26848 UBERON:0009912 denotes lobes
T12998 26898-26902 UBERON:0009912 denotes lobe
T12999 26917-26921 UBERON:0009912 denotes lobe
T13000 26946-26950 PR_EXT:000017653 denotes Fog2
T13001 26966-26976 GO_PATO_EXT:biological_patterning_process_or_quality denotes patterning
T13002 27008-27013 UBERON:0009912 denotes lobes
T13003 27048-27052 PR_EXT:000017653 denotes Fog2
T13004 27094-27098 PR_EXT:000017653 denotes Fog2
T13005 27099-27104 UBERON:0002048 denotes lungs
T13006 27196-27200 PR_EXT:000017653 denotes Fog2
T13007 27201-27206 UBERON:0002048 denotes lungs
T13008 27267-27272 UBERON:0009912 denotes lobes
T13009 27312-27321 SO_EXT:wild_type_entity_or_quality denotes wild-type
T13010 27322-27327 UBERON:0002048 denotes lungs
T13011 27381-27389 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T13012 27393-27397 PR_EXT:000017653 denotes Fog2
T13013 27405-27410 NCBITaxon:10088 denotes mouse
T13014 27444-27457 UBERON:0001103 denotes diaphragmatic
T13015 27458-27473 GO_EXT:muscle_structure_or_tissue_development denotes muscularization
T13016 27486-27495 UBERON:0002048 denotes pulmonary
T13017 27542-27550 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T13018 27559-27563 SO_EXT:0000704 denotes gene
T13019 27585-27591 GO_EXT:fatality_or_lethality denotes lethal
T13020 27602-27606 UBERON:0002048 denotes lung
T13021 27602-27606 _FRAGMENT denotes lung
T13022 27621-27632 GO:0030324 denotes development
T13023 27611-27620 UBERON:0001103 denotes diaphragm
T13024 27611-27632 GO:0060539 denotes diaphragm development
T13025 27638-27643 NCBITaxon_UBERON_EXT:child denotes child
T13026 27695-27699 PR_EXT:000017653 denotes Fog2
T13027 27700-27707 CHEBI_GO_EXT:biological_process_or_quality_or_role denotes biology
T13028 27732-27736 PR_EXT:000017653 denotes Fog2
T13029 27747-27752 NCBITaxon:10088 denotes mouse
T13030 27766-27775 UBERON:0001103 denotes diaphragm
T13031 27766-27775 _FRAGMENT denotes diaphragm
T13032 27785-27796 GO:0060539 denotes development
T13033 27780-27784 UBERON:0002048 denotes lung
T13034 27780-27796 GO:0030324 denotes lung development
T13035 27974-27983 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T13036 28016-28021 NCBITaxon:9606 denotes human
T14384 28325-28332 SO_EXT:0000704 denotes Genetic
T14385 28348-28353 NCBITaxon:10088 denotes mouse
T14386 28354-28362 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T14387 28376-28384 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T14388 28425-28434 SO_EXT:wild_type_entity_or_quality denotes Wild-type
T14389 28454-28458 NCBITaxon:10088 denotes mice
T14390 28468-28475 SO_EXT:0000704 denotes genetic
T14391 28562-28566 NCBITaxon:10088 denotes Mice
T14392 28578-28582 SO_EXT:sequence_nullness denotes null
T14393 28583-28591 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T14394 28595-28599 PR_EXT:000017653 denotes Fog2
T14395 28613-28617 SO_EXT:0000704 denotes gene
T15241 28704-28708 NCBITaxon:10088 denotes mice
T15242 28716-28727 GO:0007565 denotes pregnancies
T15243 28770-28777 UBERON:0000922 denotes embryos
T15244 28779-28786 UBERON:0000922 denotes Embryos
T15245 28866-28873 UBERON:0000922 denotes embryos
T15246 28941-28950 UBERON:0001103 denotes diaphragm
T15247 28952-28957 UBERON:0002048 denotes lungs
T15248 28963-28968 UBERON:0000948 denotes heart
T15249 28988-28993 UBERON:0002048 denotes lungs
T15250 28998-29019 UBERON:0007196 denotes tracheobronchial tree
T15251 29052-29062 UBERON:0001103 denotes diaphragms
T15252 29088-29096 UBERON:0000915 denotes thoracic
T15253 29097-29103 UBERON:0000479 denotes tissue
T15254 29125-29132 UBERON:0000922 denotes embryos
T15255 29138-29142 UBERON:0002048 denotes lung
T15256 29160-29165 UBERON:0002048 denotes lungs
T15257 29192-29199 UBERON:0000922 denotes embryos
T15258 29254-29263 CHEBI_EXT:polyester denotes polyester
T15259 29346-29354 CHEBI_EXT:33284 denotes nutrient
T15260 29355-29362 CHEBI:60004 denotes mixture
T15261 29454-29460 NCBITaxon:27592 denotes bovine
T15262 29461-29466 UBERON:0001977 denotes serum
T15263 29478-29489 CHEBI_EXT:L_glutamine denotes L-glutamine
T15264 29480-29489 CHEBI_SO_EXT:glutamine denotes glutamine
T15265 29504-29514 CHEBI:17334 denotes penicillin
T15266 29527-29539 CHEBI:17076 denotes streptomycin
T15267 29557-29571 CHEBI:2682 denotes amphotericin B
T15268 29573-29577 UBERON:0002048 denotes Lung
T15269 29624-29627 CHEBI:16526 denotes CO2
T15270 29779-29789 SO_EXT:transgenic_entity denotes Transgenic
T15271 29790-29794 NCBITaxon:10088 denotes mice
T15272 29808-29812 PR_EXT:000033987 denotes lacZ
T15273 29813-29817 SO_EXT:0000704 denotes gene
T15274 29832-29836 PR_EXT:000017653 denotes Fog2
T15275 29837-29845 SO_EXT:0000167 denotes promoter
T15276 29891-29898 NCBITaxon:33208 denotes animals
T15277 29904-29908 PR_EXT:000033987 denotes lacZ
T15278 29909-29913 SO_EXT:0000704 denotes gene
T15279 29954-29958 PR_EXT:000017653 denotes Fog2
T15280 29974-29989 GO_EXT:0004565 denotes β-galactosidase
T15281 29990-30000 GO:0010467 denotes expression
T15282 30006-30012 SO_EXT:sequence_fusion_entity_or_process denotes fusion
T15283 30013-30020 CHEBI_PR_EXT:protein denotes protein
T15284 30021-30029 SO:0001817 denotes in frame
T15285 30049-30060 CHEBI_SO_EXT:amino_acid denotes amino acids
T15286 30068-30072 PR_EXT:000017653 denotes FOG2
T15287 30073-30080 CHEBI_PR_EXT:protein denotes protein
T15288 30086-30090 PR_EXT:000017653 denotes Fog2
T15289 30091-30095 PR_EXT:000033987 denotes lacZ
T15290 30121-30125 SO_EXT:0000243 denotes ires
T15291 30131-30139 SO_EXT:0005853 denotes cassette
T15292 30156-30160 SO_EXT:sequence_nullness denotes null
T15293 30161-30167 SO_EXT:0001023 denotes allele
T15294 30171-30175 PR_EXT:000017653 denotes Fog2
T15295 30176-30180 SO_EXT:0000704 denotes gene
T15296 30186-30190 PR_EXT:000017653 denotes Fog2
T15297 30191-30195 PR_EXT:000033987 denotes LacZ
T15298 30201-30210 SO_EXT:engineered_biological_sequence denotes construct
T15299 30215-30225 SO_EXT:sequence_linearization denotes linearized
T15300 30268-30276 CL:0002322 denotes ES cells
T15301 30271-30276 CL_GO_EXT:cell denotes cells
T15302 30301-30306 SO_EXT:sequence_cloned_entity denotes clone
T15303 30377-30388 UBERON:0000358 denotes blastocysts
T15304 30390-30394 PR_EXT:000017653 denotes Fog2
T15305 30395-30399 PR_EXT:000033987 denotes lacZ
T15306 30405-30412 NCBITaxon:33208 denotes animals
T15307 30467-30471 PR_EXT:000033987 denotes lacZ
T15308 30472-30482 GO:0010467 denotes Expression
T15309 30502-30511 UBERON:0000922 denotes embryonic
T15310 30512-30517 UBERON:0002048 denotes lungs
T15311 30547-30562 GO_EXT:0015925 denotes β-galactosidase
T15312 30577-30582 CHEBI:75055 denotes X-gal
T15974 30611-30613 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T15975 30622-30630 SO_EXT:biological_sequence denotes sequence
T15976 30647-30652 NCBITaxon:10088 denotes mouse
T15977 30654-30657 CHEBI_SO_EXT:RNA denotes RNA
T15978 30700-30708 UBERON:0000915 denotes thoracic
T15979 30709-30725 UBERON:0005291 denotes embryonic tissue
T15980 30727-30729 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T15981 30758-30764 SO_EXT:0000112 denotes primer
T15982 30792-30796 PR_EXT:000017653 denotes Fog2
T15983 30797-30801 SO_EXT:0000704 denotes gene
T15984 30803-30805 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T15985 30828-30840 CHEBI_EXT:radiolabel_process denotes radiolabeled
T15986 30841-30848 SO_EXT:0000112 denotes primers
T15987 30874-30881 GO:0008380 denotes spliced
T15988 30882-30891 _FRAGMENT denotes region of
T15989 30896-30900 SO_EXT:0000842 denotes gene
T15990 30942-30952 GO_EXT:macromolecule_denaturation denotes denaturing
T15991 31006-31008 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T15992 31009-31020 SO_EXT:0000006 denotes PCR product
T15993 31025-31031 SO_EXT:sequence_cloning_process denotes cloned
T15994 31044-31050 SO_EXT:0000440 denotes vector
T15995 31065-31072 SO_EXT:sequence_cloning_process denotes Cloning
T15996 31147-31151 SO_EXT:0000704 denotes gene
T15997 31161-31168 SO_EXT:0000112 denotes primers
T15998 31170-31178 SO_EXT:biological_sequence denotes Sequence
T15999 31219-31223 SO_EXT:0000704 denotes Gene
T16277 31277-31290 GO:0097617 denotes hybridization
T16278 31336-31339 CHEBI:73702 denotes wax
T16279 31393-31406 GO:0097617 denotes hybridization
T16280 31426-31432 CHEBI_SO_EXT:molecular_probe denotes Probes
T16281 31433-31440 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labeled
T16282 31446-31449 CHEBI:37983 denotes 35S
T16283 31475-31488 GO_EXT:transcription denotes transcription
T16284 31492-31502 SO_EXT:sequence_linearization denotes linearized
T16285 31503-31510 SO_EXT:0000155 denotes plasmid
T16286 31525-31535 GO:0097617 denotes hybridized
T16287 31539-31545 UBERON:0000479 denotes tissue
T16288 31556-31562 GO:0005634 denotes Nuclei
T16662 31670-31675 NCBITaxon:9606 denotes Human
T16663 31676-31679 CHEBI_SO_EXT:DNA denotes DNA
T16664 31695-31703 SO_EXT:biological_sequence denotes sequence
T16665 31714-31717 CHEBI_SO_EXT:DNA denotes DNA
T16666 31755-31761 CHEBI:15882 denotes phenol
T16667 31762-31772 CHEBI:35255 denotes chloroform
T16668 31809-31816 UBERON:0000479 denotes tissues
T16669 31841-31848 SO_EXT:0000112 denotes Primers
T16670 31874-31878 PR_EXT:000017653 denotes FOG2
T16671 31879-31891 SO_EXT:0000195 denotes coding exons
T16672 31900-31902 SO_EXT:0000028 denotes bp
T16673 31906-31914 SO:0000357 denotes flanking
T16674 31915-31923 SO_EXT:sequence_upstreamness denotes upstream
T16675 31928-31938 SO_EXT:sequence_downstreamness denotes downstream
T16676 31939-31947 SO_EXT:biological_sequence denotes sequence
T16677 32018-32024 SO_EXT:0000112 denotes Primer
T16678 32025-32034 SO_EXT:biological_sequence denotes sequences
T16679 32064-32072 SO_EXT:biological_sequence denotes Sequence
T16680 32112-32116 SO_EXT:0000704 denotes Gene
T16681 32125-32128 CHEBI_SO_EXT:DNA denotes DNA
T16682 32194-32199 UBERON:0000178 denotes blood
T16683 32225-32230 UBERON:0000178 denotes blood
T16684 32292-32295 CHEBI_SO_EXT:DNA denotes DNA
T16685 32423-32430 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T16686 32432-32435 SO_EXT:0000694 denotes SNP
T16687 32490-32498 OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process denotes Genetics
T2496 3096-3101 GO:0007567 denotes birth
T8009 14305-14309 UBERON:0002048 denotes lung
R2 T942 T941 _lexicallyChainedTo Development,Diaphragm
R236 T2553 T2552 _lexicallyChainedTo development,diaphragmatic
R1802 T7956 T7955 _lexicallyChainedTo Development,Lung
R1803 T7965 T7964 _lexicallyChainedTo development,pulmonary
R1804 T8056 T8055 _lexicallyChainedTo cells,population of
R2525 T9878 T9877 _lexicallyChainedTo liver,left lobe of
R3002 T12913 T12912 _lexicallyChainedTo diaphragm,formation of
R3003 T12940 T12939 _lexicallyChainedTo differentiation,cell
R3004 T12951 T12950 _lexicallyChainedTo 6,Gatas
R3005 T12959 T12958 _lexicallyChainedTo development,cardiac
R3006 T13022 T13021 _lexicallyChainedTo development,lung
R3007 T13032 T13031 _lexicallyChainedTo development,diaphragm
R4580 T15989 T15988 _lexicallyChainedTo gene,region of

craft-sa-dev

Id Subject Object Predicate Lexical cue
T5761 8858-8861 DT denotes the
T5762 8869-8876 NN denotes surface
T5763 8862-8868 JJ denotes entire
T5764 8877-8879 IN denotes of
T5765 8880-8883 DT denotes the
T5766 8889-8894 NNS denotes walls
T5767 8884-8888 NN denotes body
T5768 8895-8896 -LRB- denotes (
T5769 8896-8902 NN denotes Figure
T5770 8903-8905 CD denotes 1B
T5771 8905-8906 -RRB- denotes )
T5772 8906-8907 . denotes .
T5773 8907-9506 sentence denotes Figure 1 Abnormal Pulmonary and Diaphragmatic Development in the lil Mouse (A) The mutant hypoplastic lung (right) lacks the development of the accessory lobe and the anterior portion of the right middle lobe (marked with arrows on the control sample on the left). (B) Whole diaphragms show a lack of normal muscularization in the posterolateral regions and the peripheral regions of the mutant diaphragm (control on left and lil diaphragm on the right). The number of lil mutant mice that survived to birth was less than 5% of total progeny, rather than the 25% expected for a recessive mutation.
T5774 9364-9367 DT denotes The
T5775 9368-9374 NN denotes number
T5776 9417-9420 VBD denotes was
T5777 9375-9377 IN denotes of
T5778 9378-9381 NN denotes lil
T5779 9389-9393 NNS denotes mice
T5780 9382-9388 NN denotes mutant
T5781 9394-9398 WDT denotes that
T5782 9399-9407 VBD denotes survived
T5783 9408-9410 IN denotes to
T5784 9411-9416 NN denotes birth
T5785 9421-9425 JJR denotes less
T5786 9431-9432 CD denotes 5
T5787 9426-9430 IN denotes than
T5788 9432-9433 NN denotes %
T5789 9434-9436 IN denotes of
T5790 9437-9442 JJ denotes total
T5791 9443-9450 NN denotes progeny
T5792 9450-9452 , denotes ,
T5793 9452-9458 RB denotes rather
T5794 9459-9463 IN denotes than
T5795 9464-9467 DT denotes the
T5796 9470-9471 NN denotes %
T5797 9468-9470 CD denotes 25
T5798 9472-9480 VBN denotes expected
T5799 9481-9484 IN denotes for
T5800 9485-9486 DT denotes a
T5801 9497-9505 NN denotes mutation
T5802 9487-9496 JJ denotes recessive
T5803 9505-9506 . denotes .
T5804 9506-9635 sentence denotes We evaluated litters at different embryonic time points to determine whether the reduced number was due to intra-uterine demise.
T5805 9507-9509 PRP denotes We
T5806 9510-9519 VBD denotes evaluated
T5807 9520-9527 NNS denotes litters
T5808 9528-9530 IN denotes at
T5809 9531-9540 JJ denotes different
T5810 9556-9562 NNS denotes points
T5811 9541-9550 JJ denotes embryonic
T5812 9551-9555 NN denotes time
T5813 9563-9565 TO denotes to
T5814 9566-9575 VB denotes determine
T5815 9576-9583 IN denotes whether
T5816 9603-9606 VBD denotes was
T5817 9584-9587 DT denotes the
T5818 9596-9602 NN denotes number
T5819 9588-9595 VBN denotes reduced
T5820 9607-9610 IN denotes due
T5821 9611-9613 IN denotes to
T5822 9614-9627 JJ denotes intra-uterine
T5823 9628-9634 NN denotes demise
T5824 9634-9635 . denotes .
T5825 9635-9836 sentence denotes Litters were collected at E12.5, 13.5, 15.5, 17.5, and 18.5, and embryos were genotyped and evaluated for evidence of intra-uterine demise, including growth retardation, pallor, and tissue friability.
T5826 9636-9643 NNS denotes Litters
T5827 9649-9658 VBN denotes collected
T5828 9644-9648 VBD denotes were
T5829 9659-9661 IN denotes at
T5830 9662-9667 NN denotes E12.5
T5831 9667-9669 , denotes ,
T5832 9669-9673 CD denotes 13.5
T5833 9673-9675 , denotes ,
T5834 9675-9679 CD denotes 15.5
T5835 9679-9681 , denotes ,
T5836 9681-9685 CD denotes 17.5
T5837 9685-9687 , denotes ,
T5838 9687-9690 CC denotes and
T5839 9691-9695 CD denotes 18.5
T5840 9695-9697 , denotes ,
T5841 9697-9700 CC denotes and
T5842 9701-9708 NNS denotes embryos
T5843 9714-9723 VBN denotes genotyped
T5844 9709-9713 VBD denotes were
T5845 9724-9727 CC denotes and
T5846 9728-9737 VBN denotes evaluated
T5847 9738-9741 IN denotes for
T5848 9742-9750 NN denotes evidence
T5849 9751-9753 IN denotes of
T5850 9754-9767 JJ denotes intra-uterine
T5851 9768-9774 NN denotes demise
T5852 9774-9776 , denotes ,
T5853 9776-9785 VBG denotes including
T5854 9786-9792 NN denotes growth
T5855 9793-9804 NN denotes retardation
T5856 9804-9806 , denotes ,
T5857 9806-9812 NN denotes pallor
T5858 9812-9814 , denotes ,
T5859 9814-9817 CC denotes and
T5860 9818-9824 NN denotes tissue
T5861 9825-9835 NN denotes friability
T5862 9835-9836 . denotes .
T5863 9836-9915 sentence denotes lil embryos had a progressively higher rate of demise between E13.5 and E15.5.
T5864 9837-9840 NN denotes lil
T5865 9841-9848 NNS denotes embryos
T5866 9849-9852 VBD denotes had
T5867 9853-9854 DT denotes a
T5868 9876-9880 NN denotes rate
T1000 8-16 VBN denotes Required
T1001 5-7 VBZ denotes Is
T1002 17-20 IN denotes for
T1003 21-27 JJ denotes Normal
T1004 47-58 NN denotes Development
T1005 28-37 NN denotes Diaphragm
T1006 38-41 CC denotes and
T1007 42-46 NN denotes Lung
T1008 59-61 IN denotes in
T1009 62-66 NNS denotes Mice
T1010 67-70 CC denotes and
T1011 71-77 NNS denotes Humans
T1014 77-354 sentence denotes Fog2 Required for Diaphragm and Lung Development Abstract Congenital diaphragmatic hernia and other congenital diaphragmatic defects are associated with significant mortality and morbidity in neonates; however, the molecular basis of these developmental anomalies is unknown.
T1015 137-147 JJ denotes Congenital
T1016 162-168 NN denotes hernia
T1017 148-161 JJ denotes diaphragmatic
T1019 169-172 CC denotes and
T1020 173-178 JJ denotes other
T1021 204-211 NNS denotes defects
T1022 179-189 JJ denotes congenital
T1023 190-203 JJ denotes diaphragmatic
T1024 343-345 VBZ denotes is
T1025 216-226 JJ denotes associated
T1026 227-231 IN denotes with
T1027 232-243 JJ denotes significant
T1028 244-253 NN denotes mortality
T1029 254-257 CC denotes and
T1030 258-267 NN denotes morbidity
T1031 268-270 IN denotes in
T1032 271-279 NNS denotes neonates
T1033 279-280 : denotes ;
T1034 281-288 RB denotes however
T1035 288-290 , denotes ,
T1036 290-293 DT denotes the
T1037 304-309 NN denotes basis
T1038 294-303 JJ denotes molecular
T1039 310-312 IN denotes of
T1040 313-318 DT denotes these
T1041 333-342 NNS denotes anomalies
T1042 319-332 JJ denotes developmental
T1043 346-353 JJ denotes unknown
T1044 353-354 . denotes .
T1045 354-538 sentence denotes In an analysis of E18.5 embryos derived from mice treated with N-ethyl-N-nitrosourea, we identified a mutation that causes pulmonary hypoplasia and abnormal diaphragmatic development.
T1046 355-357 IN denotes In
T1047 444-454 VBD denotes identified
T1048 358-360 DT denotes an
T1049 361-369 NN denotes analysis
T1050 370-372 IN denotes of
T1051 373-378 NN denotes E18.5
T1052 379-386 NNS denotes embryos
T1053 387-394 VBN denotes derived
T1054 395-399 IN denotes from
T1055 400-404 NNS denotes mice
T1056 405-412 VBN denotes treated
T1057 413-417 IN denotes with
T1058 418-419 NN denotes N
T1059 420-425 NN denotes ethyl
T1060 419-420 HYPH denotes -
T1061 425-426 HYPH denotes -
T1062 426-427 NN denotes N
T1063 428-439 NN denotes nitrosourea
T1064 427-428 HYPH denotes -
T1065 439-441 , denotes ,
T1066 441-443 PRP denotes we
T1067 455-456 DT denotes a
T1068 457-465 NN denotes mutation
T1069 466-470 WDT denotes that
T1070 471-477 VBZ denotes causes
T1071 478-487 JJ denotes pulmonary
T1072 488-498 NN denotes hypoplasia
T1073 499-502 CC denotes and
T1074 503-511 JJ denotes abnormal
T1075 526-537 NN denotes development
T1076 512-525 JJ denotes diaphragmatic
T1077 537-538 . denotes .
T1078 538-781 sentence denotes Fog2 (Zfpm2) maps within the recombinant interval carrying the N-ethyl-N-nitrosourea-induced mutation, and DNA sequencing of Fog2 identified a mutation in a splice donor site that generates an abnormal transcript encoding a truncated protein.
T1079 539-543 NN denotes Fog2
T1080 552-556 VBZ denotes maps
T1081 544-545 -LRB- denotes (
T1082 545-550 NN denotes Zfpm2
T1083 550-551 -RRB- denotes )
T1084 557-563 IN denotes within
T1085 564-567 DT denotes the
T1086 580-588 NN denotes interval
T1087 568-579 JJ denotes recombinant
T1088 589-597 VBG denotes carrying
T1089 598-601 DT denotes the
T1090 632-640 NN denotes mutation
T1091 602-603 NN denotes N
T1092 604-609 NN denotes ethyl
T1093 603-604 HYPH denotes -
T1094 624-631 VBN denotes induced
T1095 609-610 HYPH denotes -
T1096 610-611 NN denotes N
T1097 612-623 NN denotes nitrosourea
T1098 611-612 HYPH denotes -
T1099 623-624 HYPH denotes -
T1100 640-642 , denotes ,
T1101 642-645 CC denotes and
T1102 646-649 NN denotes DNA
T1103 650-660 NN denotes sequencing
T1104 669-679 VBD denotes identified
T1105 661-663 IN denotes of
T1106 664-668 NN denotes Fog2
T1107 680-681 DT denotes a
T1108 682-690 NN denotes mutation
T1109 691-693 IN denotes in
T1110 694-695 DT denotes a
T1111 709-713 NN denotes site
T1112 696-702 NN denotes splice
T1113 703-708 NN denotes donor
T1114 714-718 WDT denotes that
T1115 719-728 VBZ denotes generates
T1116 729-731 DT denotes an
T1117 741-751 NN denotes transcript
T1118 732-740 JJ denotes abnormal
T1119 752-760 VBG denotes encoding
T1120 761-762 DT denotes a
T1121 773-780 NN denotes protein
T1122 763-772 VBN denotes truncated
T1123 780-781 . denotes .
T1124 781-890 sentence denotes Human autopsy cases with diaphragmatic defect and pulmonary hypoplasia were evaluated for mutations in FOG2.
T1125 782-787 JJ denotes Human
T1126 796-801 NNS denotes cases
T1127 788-795 NN denotes autopsy
T1128 858-867 VBN denotes evaluated
T1129 802-806 IN denotes with
T1130 807-820 JJ denotes diaphragmatic
T1131 821-827 NN denotes defect
T1132 828-831 CC denotes and
T1133 832-841 JJ denotes pulmonary
T1134 842-852 NN denotes hypoplasia
T1135 853-857 VBD denotes were
T1136 868-871 IN denotes for
T1137 872-881 NNS denotes mutations
T1138 882-884 IN denotes in
T1139 885-889 NN denotes FOG2
T1140 889-890 . denotes .
T1141 890-1110 sentence denotes Sequence analysis revealed a de novo mutation resulting in a premature stop codon in a child who died on the first day of life secondary to severe bilateral pulmonary hypoplasia and an abnormally muscularized diaphragm.
T1142 891-899 NN denotes Sequence
T1143 900-908 NN denotes analysis
T1144 909-917 VBD denotes revealed
T1145 918-919 DT denotes a
T1146 928-936 NN denotes mutation
T1147 920-922 FW denotes de
T1148 923-927 FW denotes novo
T1149 937-946 VBG denotes resulting
T1150 947-949 IN denotes in
T1151 950-951 DT denotes a
T1152 967-972 NN denotes codon
T1153 952-961 JJ denotes premature
T1154 962-966 NN denotes stop
T1155 973-975 IN denotes in
T1156 976-977 DT denotes a
T1157 978-983 NN denotes child
T1158 984-987 WP denotes who
T1159 988-992 VBD denotes died
T1160 993-995 IN denotes on
T1161 996-999 DT denotes the
T1162 1006-1009 NN denotes day
T1163 1000-1005 JJ denotes first
T1164 1010-1012 IN denotes of
T1165 1013-1017 NN denotes life
T1166 1018-1027 JJ denotes secondary
T1167 1028-1030 IN denotes to
T1168 1031-1037 JJ denotes severe
T1169 1058-1068 NN denotes hypoplasia
T1170 1038-1047 JJ denotes bilateral
T1171 1048-1057 JJ denotes pulmonary
T1172 1069-1072 CC denotes and
T1173 1073-1075 DT denotes an
T1174 1100-1109 NN denotes diaphragm
T1175 1076-1086 RB denotes abnormally
T1176 1087-1099 VBN denotes muscularized
T1177 1109-1110 . denotes .
T1178 1110-1279 sentence denotes Using a phenotype-driven approach, we have established that Fog2 is required for normal diaphragm and lung development, a role that has not been previously appreciated.
T1179 1111-1116 VBG denotes Using
T1180 1154-1165 VBN denotes established
T1181 1117-1118 DT denotes a
T1182 1136-1144 NN denotes approach
T1183 1119-1128 NN denotes phenotype
T1184 1129-1135 VBN denotes driven
T1185 1128-1129 HYPH denotes -
T1186 1144-1146 , denotes ,
T1187 1146-1148 PRP denotes we
T1188 1149-1153 VBP denotes have
T1189 1166-1170 IN denotes that
T1190 1179-1187 VBN denotes required
T1191 1171-1175 NN denotes Fog2
T1192 1176-1178 VBZ denotes is
T1193 1188-1191 IN denotes for
T1194 1192-1198 JJ denotes normal
T1195 1218-1229 NN denotes development
T1196 1199-1208 NN denotes diaphragm
T1197 1209-1212 CC denotes and
T1198 1213-1217 NN denotes lung
T1199 1229-1231 , denotes ,
T1200 1231-1232 DT denotes a
T1201 1233-1237 NN denotes role
T1202 1238-1242 WDT denotes that
T1203 1267-1278 VBN denotes appreciated
T1204 1243-1246 VBZ denotes has
T1205 1247-1250 RB denotes not
T1206 1251-1255 VBN denotes been
T1207 1256-1266 RB denotes previously
T1208 1278-1279 . denotes .
T1209 1279-1570 sentence denotes FOG2 is the first gene implicated in the pathogenesis of nonsyndromic human congenital diaphragmatic defects, and its necessity for pulmonary development validates the hypothesis that neonates with congenital diaphragmatic hernia may also have primary pulmonary developmental abnormalities.
T1210 1280-1284 NN denotes FOG2
T1211 1285-1287 VBZ denotes is
T1212 1288-1291 DT denotes the
T1213 1298-1302 NN denotes gene
T1214 1292-1297 JJ denotes first
T1215 1303-1313 VBN denotes implicated
T1216 1314-1316 IN denotes in
T1217 1317-1320 DT denotes the
T1218 1321-1333 NN denotes pathogenesis
T1219 1334-1336 IN denotes of
T1220 1337-1349 JJ denotes nonsyndromic
T1221 1381-1388 NNS denotes defects
T1222 1350-1355 JJ denotes human
T1223 1356-1366 JJ denotes congenital
T1224 1367-1380 JJ denotes diaphragmatic
T1225 1388-1390 , denotes ,
T1226 1390-1393 CC denotes and
T1227 1394-1397 PRP$ denotes its
T1228 1398-1407 NN denotes necessity
T1229 1434-1443 VBZ denotes validates
T1230 1408-1411 IN denotes for
T1231 1412-1421 JJ denotes pulmonary
T1232 1422-1433 NN denotes development
T1233 1444-1447 DT denotes the
T1234 1448-1458 NN denotes hypothesis
T1235 1459-1463 IN denotes that
T1236 1519-1523 VB denotes have
T1237 1464-1472 NNS denotes neonates
T1238 1473-1477 IN denotes with
T1239 1478-1488 JJ denotes congenital
T1240 1503-1509 NN denotes hernia
T1241 1489-1502 JJ denotes diaphragmatic
T1242 1510-1513 MD denotes may
T1243 1514-1518 RB denotes also
T1244 1524-1531 JJ denotes primary
T1245 1556-1569 NNS denotes abnormalities
T1246 1532-1541 JJ denotes pulmonary
T1247 1542-1555 JJ denotes developmental
T1248 1569-1570 . denotes .
T2580 3027-3037 JJ denotes Congenital
T2581 3052-3059 NNS denotes defects
T2582 3038-3051 JJ denotes diaphragmatic
T2583 3060-3063 VBP denotes are
T2584 3064-3065 DT denotes a
T2585 3066-3074 NN denotes spectrum
T2586 3075-3077 IN denotes of
T2587 3078-3088 RB denotes relatively
T2588 3089-3095 JJ denotes common
T2589 3102-3109 NNS denotes defects
T2590 3096-3101 NN denotes birth
T2591 3109-3110 . denotes .
T2592 3110-3455 sentence denotes The Bochdalek or posterolateral hernias (often referred to as congenital diaphragmatic hernia [CDH]) occur in 1/3,000 live births [1], and although these are the most common type of diaphragmatic defect presenting at birth, diaphragmatic aplasia and diaphragmatic muscularization defects (eventrations) may have a similar clinical presentation.
T2593 3111-3114 DT denotes The
T2594 3115-3124 NNP denotes Bochdalek
T2595 3212-3217 VBP denotes occur
T2596 3125-3127 CC denotes or
T2597 3128-3142 JJ denotes posterolateral
T2598 3143-3150 NNS denotes hernias
T2599 3151-3152 -LRB- denotes (
T2600 3152-3157 RB denotes often
T2601 3158-3166 VBN denotes referred
T2602 3167-3169 IN denotes to
T2603 3170-3172 IN denotes as
T2604 3173-3183 JJ denotes congenital
T2605 3198-3204 NN denotes hernia
T2606 3184-3197 JJ denotes diaphragmatic
T2607 3205-3206 -LRB- denotes [
T2608 3206-3209 NN denotes CDH
T2609 3209-3210 -RRB- denotes ]
T2610 3210-3211 -RRB- denotes )
T2611 3218-3220 IN denotes in
T2612 3221-3222 CD denotes 1
T2613 3223-3228 CD denotes 3,000
T2614 3222-3223 SYM denotes /
T2615 3234-3240 NNS denotes births
T2616 3229-3233 JJ denotes live
T2617 3241-3242 -LRB- denotes [
T2618 3242-3243 CD denotes 1
T2619 3243-3244 -RRB- denotes ]
T2620 3244-3246 , denotes ,
T2621 3246-3249 CC denotes and
T2622 3250-3258 IN denotes although
T2623 3265-3268 VBP denotes are
T2624 3259-3264 DT denotes these
T2625 3418-3422 VB denotes have
T2626 3269-3272 DT denotes the
T2627 3285-3289 NN denotes type
T2628 3273-3277 RBS denotes most
T2629 3278-3284 JJ denotes common
T2630 3290-3292 IN denotes of
T2631 3293-3306 JJ denotes diaphragmatic
T2632 3307-3313 NN denotes defect
T2633 3314-3324 VBG denotes presenting
T2634 3325-3327 IN denotes at
T2635 3328-3333 NN denotes birth
T2636 3333-3335 , denotes ,
T2637 3335-3348 JJ denotes diaphragmatic
T2638 3349-3356 NN denotes aplasia
T2639 3357-3360 CC denotes and
T2640 3361-3374 JJ denotes diaphragmatic
T2641 3391-3398 NNS denotes defects
T2642 3375-3390 NN denotes muscularization
T2643 3399-3400 -LRB- denotes (
T2644 3400-3412 NNS denotes eventrations
T2645 3412-3413 -RRB- denotes )
T2646 3414-3417 MD denotes may
T2647 3423-3424 DT denotes a
T2648 3442-3454 NN denotes presentation
T2649 3425-3432 JJ denotes similar
T2650 3433-3441 JJ denotes clinical
T2651 3454-3455 . denotes .
T2652 3455-3604 sentence denotes Making specific anatomic distinctions among these types of defects can be difficult without direct gross (intraoperative or postmortem) examination.
T2653 3456-3462 VBG denotes Making
T2654 3527-3529 VB denotes be
T2655 3463-3471 JJ denotes specific
T2656 3481-3493 NNS denotes distinctions
T2657 3472-3480 JJ denotes anatomic
T2658 3494-3499 IN denotes among
T2659 3500-3505 DT denotes these
T2660 3506-3511 NNS denotes types
T2661 3512-3514 IN denotes of
T2662 3515-3522 NNS denotes defects
T2663 3523-3526 MD denotes can
T2664 3530-3539 JJ denotes difficult
T2665 3540-3547 IN denotes without
T2666 3548-3554 JJ denotes direct
T2667 3592-3603 NN denotes examination
T2668 3555-3560 JJ denotes gross
T2669 3561-3562 -LRB- denotes (
T2670 3562-3576 JJ denotes intraoperative
T2671 3577-3579 CC denotes or
T2672 3580-3590 JJ denotes postmortem
T2673 3590-3591 -RRB- denotes )
T2674 3603-3604 . denotes .
T2675 3604-3708 sentence denotes Pulmonary hypoplasia associated with these diaphragmatic defects causes severe mortality and morbidity.
T2676 3605-3614 JJ denotes Pulmonary
T2677 3615-3625 NN denotes hypoplasia
T2678 3670-3676 VBZ denotes causes
T2679 3626-3636 JJ denotes associated
T2680 3637-3641 IN denotes with
T2681 3642-3647 DT denotes these
T2682 3662-3669 NNS denotes defects
T2683 3648-3661 JJ denotes diaphragmatic
T2684 3677-3683 JJ denotes severe
T2685 3684-3693 NN denotes mortality
T2686 3694-3697 CC denotes and
T2687 3698-3707 NN denotes morbidity
T2688 3707-3708 . denotes .
T2689 3708-3830 sentence denotes The pathogenesis and developmental relationship between diaphragmatic defects and pulmonary hypoplasia is not understood.
T2690 3709-3712 DT denotes The
T2691 3713-3725 NN denotes pathogenesis
T2692 3819-3829 VBN denotes understood
T2693 3726-3729 CC denotes and
T2694 3730-3743 JJ denotes developmental
T2695 3744-3756 NN denotes relationship
T2696 3757-3764 IN denotes between
T2697 3765-3778 JJ denotes diaphragmatic
T2698 3779-3786 NNS denotes defects
T2699 3787-3790 CC denotes and
T2700 3791-3800 JJ denotes pulmonary
T2701 3801-3811 NN denotes hypoplasia
T2702 3812-3814 VBZ denotes is
T2703 3815-3818 RB denotes not
T2704 3829-3830 . denotes .
T2705 3830-4192 sentence denotes Although advances in the medical management of pulmonary hypoplasia may have decreased the mortality associated with CDH patients who survive to receive care at high-volume centers [2,3], the population-based mortality has been reported to be as great as 62%, and there are a large number of deaths prior to birth or to transfer to a tertiary care facility [4].
T2706 3831-3839 IN denotes Although
T2707 3908-3917 VBN denotes decreased
T2708 3840-3848 NNS denotes advances
T2709 3849-3851 IN denotes in
T2710 3852-3855 DT denotes the
T2711 3864-3874 NN denotes management
T2712 3856-3863 JJ denotes medical
T2713 3875-3877 IN denotes of
T2714 3878-3887 JJ denotes pulmonary
T2715 3888-3898 NN denotes hypoplasia
T2716 3899-3902 MD denotes may
T2717 3903-3907 VB denotes have
T2718 4059-4067 VBN denotes reported
T2719 3918-3921 DT denotes the
T2720 3922-3931 NN denotes mortality
T2721 3932-3942 JJ denotes associated
T2722 3943-3947 IN denotes with
T2723 3948-3951 NN denotes CDH
T2724 3952-3960 NNS denotes patients
T2725 3961-3964 WP denotes who
T2726 3965-3972 VBP denotes survive
T2727 3973-3975 TO denotes to
T2728 3976-3983 VB denotes receive
T2729 3984-3988 NN denotes care
T2730 3989-3991 IN denotes at
T2731 3992-3996 JJ denotes high
T2732 3997-4003 NN denotes volume
T2733 3996-3997 HYPH denotes -
T2734 4004-4011 NNS denotes centers
T2735 4012-4013 -LRB- denotes [
T2736 4015-4016 CD denotes 3
T2737 4013-4014 CD denotes 2
T2738 4014-4015 , denotes ,
T2739 4016-4017 -RRB- denotes ]
T2740 4017-4019 , denotes ,
T2741 4019-4022 DT denotes the
T2742 4040-4049 NN denotes mortality
T2743 4023-4033 NN denotes population
T2744 4034-4039 VBN denotes based
T2745 4033-4034 HYPH denotes -
T2746 4050-4053 VBZ denotes has
T2747 4054-4058 VBN denotes been
T2748 4068-4070 TO denotes to
T2749 4071-4073 VB denotes be
T2750 4074-4076 RB denotes as
T2751 4086-4088 CD denotes 62
T2752 4077-4082 JJ denotes great
T2753 4083-4085 IN denotes as
T2754 4088-4089 NN denotes %
T2755 4089-4091 , denotes ,
T2756 4091-4094 CC denotes and
T2757 4095-4100 EX denotes there
T2758 4101-4104 VBP denotes are
T2759 4105-4106 DT denotes a
T2760 4113-4119 NN denotes number
T2761 4107-4112 JJ denotes large
T2762 4120-4122 IN denotes of
T2763 4123-4129 NNS denotes deaths
T2764 4130-4135 JJ denotes prior
T2765 4136-4138 IN denotes to
T2766 4139-4144 NN denotes birth
T2767 4145-4147 CC denotes or
T2768 4148-4150 IN denotes to
T2769 4151-4159 NN denotes transfer
T2770 4160-4162 IN denotes to
T2771 4163-4164 DT denotes a
T2772 4179-4187 NN denotes facility
T2773 4165-4173 JJ denotes tertiary
T2774 4174-4178 NN denotes care
T2775 4188-4189 -LRB- denotes [
T2776 4189-4190 CD denotes 4
T2777 4190-4191 -RRB- denotes ]
T2778 4191-4192 . denotes .
T2779 4192-4400 sentence denotes As these patients commonly present with severe respiratory failure at birth, therapy has been centered around developing better methods to provide ventilatory support while not producing further lung injury.
T2780 4193-4195 IN denotes As
T2781 4220-4227 VBP denotes present
T2782 4196-4201 DT denotes these
T2783 4202-4210 NNS denotes patients
T2784 4211-4219 RB denotes commonly
T2785 4287-4295 VBN denotes centered
T2786 4228-4232 IN denotes with
T2787 4233-4239 JJ denotes severe
T2788 4252-4259 NN denotes failure
T2789 4240-4251 JJ denotes respiratory
T2790 4260-4262 IN denotes at
T2791 4263-4268 NN denotes birth
T2792 4268-4270 , denotes ,
T2793 4270-4277 NN denotes therapy
T2794 4278-4281 VBZ denotes has
T2795 4282-4286 VBN denotes been
T2796 4296-4302 IN denotes around
T2797 4303-4313 VBG denotes developing
T2798 4314-4320 JJR denotes better
T2799 4321-4328 NNS denotes methods
T2800 4329-4331 TO denotes to
T2801 4332-4339 VB denotes provide
T2802 4340-4351 JJ denotes ventilatory
T2803 4352-4359 NN denotes support
T2804 4360-4365 IN denotes while
T2805 4370-4379 VBG denotes producing
T2806 4366-4369 RB denotes not
T2807 4380-4387 JJ denotes further
T2808 4393-4399 NN denotes injury
T2809 4388-4392 NN denotes lung
T2810 4399-4400 . denotes .
T2811 4400-4611 sentence denotes Extracorporeal membrane oxygenation (ECMO) is used in some centers to provide an extended period of cardiopulmonary bypass [5,6], while other centers have success using other ventilatory support techniques [7].
T2812 4401-4415 JJ denotes Extracorporeal
T2813 4425-4436 NN denotes oxygenation
T2814 4416-4424 NN denotes membrane
T2815 4447-4451 VBN denotes used
T2816 4437-4438 -LRB- denotes (
T2817 4438-4442 NN denotes ECMO
T2818 4442-4443 -RRB- denotes )
T2819 4444-4446 VBZ denotes is
T2820 4452-4454 IN denotes in
T2821 4455-4459 DT denotes some
T2822 4460-4467 NNS denotes centers
T2823 4468-4470 TO denotes to
T2824 4471-4478 VB denotes provide
T2825 4479-4481 DT denotes an
T2826 4491-4497 NN denotes period
T2827 4482-4490 JJ denotes extended
T2828 4498-4500 IN denotes of
T2829 4501-4516 JJ denotes cardiopulmonary
T2830 4517-4523 NN denotes bypass
T2831 4524-4525 -LRB- denotes [
T2832 4527-4528 CD denotes 6
T2833 4525-4526 CD denotes 5
T2834 4526-4527 , denotes ,
T2835 4528-4529 -RRB- denotes ]
T2836 4529-4531 , denotes ,
T2837 4531-4536 IN denotes while
T2838 4551-4555 VBP denotes have
T2839 4537-4542 JJ denotes other
T2840 4543-4550 NNS denotes centers
T2841 4556-4563 NN denotes success
T2842 4564-4569 VBG denotes using
T2843 4570-4575 JJ denotes other
T2844 4596-4606 NNS denotes techniques
T2845 4576-4587 JJ denotes ventilatory
T2846 4588-4595 NN denotes support
T2847 4607-4608 -LRB- denotes [
T2848 4608-4609 CD denotes 7
T2849 4609-4610 -RRB- denotes ]
T2850 4610-4611 . denotes .
T2851 4611-4901 sentence denotes The morbidity in those who survive is high, and many patients survive with chronic respiratory insufficiency, cognitive and neuromotor deficits, and hearing loss as a result of necessary intensive interventions and associated structural and irreversible developmental abnormalities [8–11].
T2852 4612-4615 DT denotes The
T2853 4616-4625 NN denotes morbidity
T2854 4647-4649 VBZ denotes is
T2855 4626-4628 IN denotes in
T2856 4629-4634 DT denotes those
T2857 4635-4638 WP denotes who
T2858 4639-4646 VBP denotes survive
T2859 4650-4654 JJ denotes high
T2860 4654-4656 , denotes ,
T2861 4656-4659 CC denotes and
T2862 4660-4664 JJ denotes many
T2863 4665-4673 NNS denotes patients
T2864 4674-4681 VBP denotes survive
T2865 4682-4686 IN denotes with
T2866 4687-4694 JJ denotes chronic
T2867 4707-4720 NN denotes insufficiency
T2868 4695-4706 JJ denotes respiratory
T2869 4720-4722 , denotes ,
T2870 4722-4731 JJ denotes cognitive
T2871 4747-4755 NNS denotes deficits
T2872 4732-4735 CC denotes and
T2873 4736-4746 JJ denotes neuromotor
T2874 4755-4757 , denotes ,
T2875 4757-4760 CC denotes and
T2876 4761-4768 NN denotes hearing
T2877 4769-4773 NN denotes loss
T2878 4774-4776 IN denotes as
T2879 4777-4778 DT denotes a
T2880 4779-4785 NN denotes result
T2881 4786-4788 IN denotes of
T2882 4789-4798 JJ denotes necessary
T2883 4809-4822 NNS denotes interventions
T2884 4799-4808 JJ denotes intensive
T2885 4823-4826 CC denotes and
T2886 4827-4837 VBN denotes associated
T2887 4880-4893 NNS denotes abnormalities
T2888 4838-4848 JJ denotes structural
T2889 4849-4852 CC denotes and
T2890 4853-4865 JJ denotes irreversible
T2891 4866-4879 JJ denotes developmental
T2892 4894-4895 -LRB- denotes [
T2893 4895-4896 CD denotes 8
T2894 4896-4897 SYM denotes –
T2895 4897-4899 CD denotes 11
T2896 4899-4900 -RRB- denotes ]
T2897 4900-4901 . denotes .
T2898 4901-5047 sentence denotes To date, there have been no specific mutations found to be associated with nonsyndromic diaphragmatic defects and pulmonary hypoplasia in humans.
T2899 4902-4904 IN denotes To
T2900 4922-4926 VBN denotes been
T2901 4905-4909 NN denotes date
T2902 4909-4911 , denotes ,
T2903 4911-4916 EX denotes there
T2904 4917-4921 VBP denotes have
T2905 4927-4929 DT denotes no
T2906 4939-4948 NNS denotes mutations
T2907 4930-4938 JJ denotes specific
T2908 4949-4954 VBN denotes found
T2909 4955-4957 TO denotes to
T2910 4958-4960 VB denotes be
T2911 4961-4971 JJ denotes associated
T2912 4972-4976 IN denotes with
T2913 4977-4989 JJ denotes nonsyndromic
T2914 5004-5011 NNS denotes defects
T2915 4990-5003 JJ denotes diaphragmatic
T2916 5012-5015 CC denotes and
T2917 5016-5025 JJ denotes pulmonary
T2918 5026-5036 NN denotes hypoplasia
T2919 5037-5039 IN denotes in
T2920 5040-5046 NNS denotes humans
T2921 5046-5047 . denotes .
T2922 5047-5194 sentence denotes The heritability of these defects is unclear, as the high morbidity and mortality limit the collection of multigenerational families for analysis.
T2923 5048-5051 DT denotes The
T2924 5052-5064 NN denotes heritability
T2925 5082-5084 VBZ denotes is
T2926 5065-5067 IN denotes of
T2927 5068-5073 DT denotes these
T2928 5074-5081 NNS denotes defects
T2929 5085-5092 JJ denotes unclear
T2930 5092-5094 , denotes ,
T2931 5094-5096 IN denotes as
T2932 5130-5135 VBP denotes limit
T2933 5097-5100 DT denotes the
T2934 5106-5115 NN denotes morbidity
T2935 5101-5105 JJ denotes high
T2936 5116-5119 CC denotes and
T2937 5120-5129 NN denotes mortality
T2938 5136-5139 DT denotes the
T2939 5140-5150 NN denotes collection
T2940 5151-5153 IN denotes of
T2941 5154-5171 JJ denotes multigenerational
T2942 5172-5180 NNS denotes families
T2943 5181-5184 IN denotes for
T2944 5185-5193 NN denotes analysis
T2945 5193-5194 . denotes .
T2946 5194-5383 sentence denotes The genetic etiologies are likely to be complex and probably arise from different mutations in various parts of the molecular developmental pathways required for diaphragmatic development.
T2947 5195-5198 DT denotes The
T2948 5207-5217 NNS denotes etiologies
T2949 5199-5206 JJ denotes genetic
T2950 5218-5221 VBP denotes are
T2951 5222-5228 JJ denotes likely
T2952 5229-5231 TO denotes to
T2953 5232-5234 VB denotes be
T2954 5235-5242 JJ denotes complex
T2955 5243-5246 CC denotes and
T2956 5247-5255 RB denotes probably
T2957 5256-5261 VBP denotes arise
T2958 5262-5266 IN denotes from
T2959 5267-5276 JJ denotes different
T2960 5277-5286 NNS denotes mutations
T2961 5287-5289 IN denotes in
T2962 5290-5297 JJ denotes various
T2963 5298-5303 NNS denotes parts
T2964 5304-5306 IN denotes of
T2965 5307-5310 DT denotes the
T2966 5335-5343 NNS denotes pathways
T2967 5311-5320 JJ denotes molecular
T2968 5321-5334 JJ denotes developmental
T2969 5344-5352 VBN denotes required
T2970 5353-5356 IN denotes for
T2971 5357-5370 JJ denotes diaphragmatic
T2972 5371-5382 NN denotes development
T2973 5382-5383 . denotes .
T2974 5383-5502 sentence denotes Indeed, there are numerous reports implicating different chromosomal abnormalities in the pathogenesis of CDH [12,13].
T2975 5384-5390 RB denotes Indeed
T2976 5398-5401 VBP denotes are
T2977 5390-5392 , denotes ,
T2978 5392-5397 EX denotes there
T2979 5402-5410 JJ denotes numerous
T2980 5411-5418 NNS denotes reports
T2981 5419-5430 VBG denotes implicating
T2982 5431-5440 JJ denotes different
T2983 5453-5466 NNS denotes abnormalities
T2984 5441-5452 JJ denotes chromosomal
T2985 5467-5469 IN denotes in
T2986 5470-5473 DT denotes the
T2987 5474-5486 NN denotes pathogenesis
T2988 5487-5489 IN denotes of
T2989 5490-5493 NN denotes CDH
T2990 5494-5495 -LRB- denotes [
T2991 5498-5500 CD denotes 13
T2992 5495-5497 CD denotes 12
T2993 5497-5498 , denotes ,
T2994 5500-5501 -RRB- denotes ]
T2995 5501-5502 . denotes .
T2996 5502-5771 sentence denotes Given the difficulty of studying lethal developmental abnormalities in humans, it is of great potential utility to develop animal models of human birth defects, as the specific genetic abnormalities found in animal models can then be investigated in human populations.
T2997 5503-5508 VBN denotes Given
T2998 5585-5587 VBZ denotes is
T2999 5509-5512 DT denotes the
T3000 5513-5523 NN denotes difficulty
T3001 5524-5526 IN denotes of
T3002 5527-5535 VBG denotes studying
T3003 5536-5542 JJ denotes lethal
T3004 5557-5570 NNS denotes abnormalities
T3005 5543-5556 JJ denotes developmental
T3006 5571-5573 IN denotes in
T3007 5574-5580 NNS denotes humans
T3008 5580-5582 , denotes ,
T3009 5582-5584 PRP denotes it
T3010 5588-5590 IN denotes of
T3011 5591-5596 JJ denotes great
T3012 5607-5614 NN denotes utility
T3013 5597-5606 JJ denotes potential
T3014 5615-5617 TO denotes to
T3015 5618-5625 VB denotes develop
T3016 5626-5632 NN denotes animal
T3017 5633-5639 NNS denotes models
T3018 5640-5642 IN denotes of
T3019 5643-5648 JJ denotes human
T3020 5655-5662 NNS denotes defects
T3021 5649-5654 NN denotes birth
T3022 5662-5664 , denotes ,
T3023 5664-5666 IN denotes as
T3024 5737-5749 VBN denotes investigated
T3025 5667-5670 DT denotes the
T3026 5688-5701 NNS denotes abnormalities
T3027 5671-5679 JJ denotes specific
T3028 5680-5687 JJ denotes genetic
T3029 5702-5707 VBN denotes found
T3030 5708-5710 IN denotes in
T3031 5711-5717 NN denotes animal
T3032 5718-5724 NNS denotes models
T3033 5725-5728 MD denotes can
T3034 5729-5733 RB denotes then
T3035 5734-5736 VB denotes be
T3036 5750-5752 IN denotes in
T3037 5753-5758 JJ denotes human
T3038 5759-5770 NNS denotes populations
T3039 5770-5771 . denotes .
T3040 5771-5930 sentence denotes We screened mice treated with the chemical mutagen N-ethyl-N-nitrosourea (ENU) for lines with developmental defects that present in the perinatal period [14].
T3041 5772-5774 PRP denotes We
T3042 5775-5783 VBD denotes screened
T3043 5784-5788 NNS denotes mice
T3044 5789-5796 VBN denotes treated
T3045 5797-5801 IN denotes with
T3046 5802-5805 DT denotes the
T3047 5815-5822 NN denotes mutagen
T3048 5806-5814 JJ denotes chemical
T3049 5823-5824 NN denotes N
T3050 5825-5830 NN denotes ethyl
T3051 5824-5825 HYPH denotes -
T3052 5830-5831 HYPH denotes -
T3053 5831-5832 NN denotes N
T3054 5833-5844 NN denotes nitrosourea
T3055 5832-5833 HYPH denotes -
T3056 5845-5846 -LRB- denotes (
T3057 5846-5849 NN denotes ENU
T3058 5849-5850 -RRB- denotes )
T3059 5851-5854 IN denotes for
T3060 5855-5860 NNS denotes lines
T3061 5861-5865 IN denotes with
T3062 5866-5879 JJ denotes developmental
T3063 5880-5887 NNS denotes defects
T3064 5888-5892 WDT denotes that
T3065 5893-5900 VBP denotes present
T3066 5901-5903 IN denotes in
T3067 5904-5907 DT denotes the
T3068 5918-5924 NN denotes period
T3069 5908-5917 JJ denotes perinatal
T3070 5925-5926 -LRB- denotes [
T3071 5926-5928 CD denotes 14
T3072 5928-5929 -RRB- denotes ]
T3073 5929-5930 . denotes .
T3074 5930-6104 sentence denotes From this screen, we identified a line of mice carrying a recessive mutation that results in primary pulmonary hypoplasia and abnormal diaphragmatic and cardiac development.
T3075 5931-5935 IN denotes From
T3076 5952-5962 VBD denotes identified
T3077 5936-5940 DT denotes this
T3078 5941-5947 NN denotes screen
T3079 5947-5949 , denotes ,
T3080 5949-5951 PRP denotes we
T3081 5963-5964 DT denotes a
T3082 5965-5969 NN denotes line
T3083 5970-5972 IN denotes of
T3084 5973-5977 NNS denotes mice
T3085 5978-5986 VBG denotes carrying
T3086 5987-5988 DT denotes a
T3087 5999-6007 NN denotes mutation
T3088 5989-5998 JJ denotes recessive
T3089 6008-6012 WDT denotes that
T3090 6013-6020 VBZ denotes results
T3091 6021-6023 IN denotes in
T3092 6024-6031 JJ denotes primary
T3093 6042-6052 NN denotes hypoplasia
T3094 6032-6041 JJ denotes pulmonary
T3095 6053-6056 CC denotes and
T3096 6057-6065 JJ denotes abnormal
T3097 6092-6103 NN denotes development
T3098 6066-6079 JJ denotes diaphragmatic
T3099 6080-6083 CC denotes and
T3100 6084-6091 JJ denotes cardiac
T3101 6103-6104 . denotes .
T3102 6104-6309 sentence denotes Positional cloning analysis identified Fog2 (Zfpm2) as a likely candidate, and DNA sequencing revealed a mutation in a splice donor site that generates an abnormal transcript encoding a truncated protein.
T3103 6105-6115 JJ denotes Positional
T3104 6124-6132 NN denotes analysis
T3105 6116-6123 NN denotes cloning
T3106 6133-6143 VBD denotes identified
T3107 6144-6148 NN denotes Fog2
T3108 6149-6150 -LRB- denotes (
T3109 6150-6155 NN denotes Zfpm2
T3110 6155-6156 -RRB- denotes )
T3111 6157-6159 IN denotes as
T3112 6160-6161 DT denotes a
T3113 6169-6178 NN denotes candidate
T3114 6162-6168 JJ denotes likely
T3115 6178-6180 , denotes ,
T3116 6180-6183 CC denotes and
T3117 6184-6187 NN denotes DNA
T3118 6188-6198 NN denotes sequencing
T3119 6199-6207 VBD denotes revealed
T3120 6208-6209 DT denotes a
T3121 6210-6218 NN denotes mutation
T3122 6219-6221 IN denotes in
T3123 6222-6223 DT denotes a
T3124 6237-6241 NN denotes site
T3125 6224-6230 NN denotes splice
T3126 6231-6236 NN denotes donor
T3127 6242-6246 WDT denotes that
T3128 6247-6256 VBZ denotes generates
T3129 6257-6259 DT denotes an
T3130 6269-6279 NN denotes transcript
T3131 6260-6268 JJ denotes abnormal
T3132 6280-6288 VBG denotes encoding
T3133 6289-6290 DT denotes a
T3134 6301-6308 NN denotes protein
T3135 6291-6300 VBN denotes truncated
T3136 6308-6309 . denotes .
T3137 6309-6571 sentence denotes This result suggested that we examine the orthologous gene in humans with similar developmental defects, and we report the finding of a de novo nonsense mutation in FOG2 in a patient who died at birth with a diaphragmatic defect and severe pulmonary hypoplasia.
T3138 6310-6314 DT denotes This
T3139 6315-6321 NN denotes result
T3140 6322-6331 VBD denotes suggested
T3141 6332-6336 IN denotes that
T3142 6340-6347 VBP denotes examine
T3143 6337-6339 PRP denotes we
T3144 6348-6351 DT denotes the
T3145 6364-6368 NN denotes gene
T3146 6352-6363 JJ denotes orthologous
T3147 6369-6371 IN denotes in
T3148 6372-6378 NNS denotes humans
T3149 6379-6383 IN denotes with
T3150 6384-6391 JJ denotes similar
T3151 6406-6413 NNS denotes defects
T3152 6392-6405 JJ denotes developmental
T3153 6413-6415 , denotes ,
T3154 6415-6418 CC denotes and
T3155 6419-6421 PRP denotes we
T3156 6422-6428 VBP denotes report
T3157 6429-6432 DT denotes the
T3158 6433-6440 NN denotes finding
T3159 6441-6443 IN denotes of
T3160 6444-6445 DT denotes a
T3161 6463-6471 NN denotes mutation
T3162 6446-6448 FW denotes de
T3163 6449-6453 FW denotes novo
T3164 6454-6462 NN denotes nonsense
T3165 6472-6474 IN denotes in
T3166 6475-6479 NN denotes FOG2
T3167 6480-6482 IN denotes in
T3168 6483-6484 DT denotes a
T3169 6485-6492 NN denotes patient
T3170 6493-6496 WP denotes who
T3171 6497-6501 VBD denotes died
T3172 6502-6504 IN denotes at
T3173 6505-6510 NN denotes birth
T3174 6511-6515 IN denotes with
T3175 6516-6517 DT denotes a
T3176 6532-6538 NN denotes defect
T3177 6518-6531 JJ denotes diaphragmatic
T3178 6539-6542 CC denotes and
T3179 6543-6549 JJ denotes severe
T3180 6560-6570 NN denotes hypoplasia
T3181 6550-6559 JJ denotes pulmonary
T3182 6570-6571 . denotes .
T3183 6571-6655 sentence denotes This is the first reported mutation associated with these abnormalities in a human.
T3184 6572-6576 DT denotes This
T3185 6577-6579 VBZ denotes is
T3186 6580-6583 DT denotes the
T3187 6599-6607 NN denotes mutation
T3188 6584-6589 JJ denotes first
T3189 6590-6598 VBN denotes reported
T3190 6608-6618 JJ denotes associated
T3191 6619-6623 IN denotes with
T3192 6624-6629 DT denotes these
T3193 6630-6643 NNS denotes abnormalities
T3194 6644-6646 IN denotes in
T3195 6647-6648 DT denotes a
T3196 6649-6654 NN denotes human
T3197 6654-6655 . denotes .
T3198 6655-6795 sentence denotes We present additional data that provide direct evidence that pulmonary hypoplasia may be a primary component of this spectrum of disorders.
T3199 6656-6658 PRP denotes We
T3200 6659-6666 VBP denotes present
T3201 6667-6677 JJ denotes additional
T3202 6678-6682 NNS denotes data
T3203 6683-6687 WDT denotes that
T3204 6688-6695 VBP denotes provide
T3205 6696-6702 JJ denotes direct
T3206 6703-6711 NN denotes evidence
T3207 6712-6716 IN denotes that
T3208 6742-6744 VB denotes be
T3209 6717-6726 JJ denotes pulmonary
T3210 6727-6737 NN denotes hypoplasia
T3211 6738-6741 MD denotes may
T3212 6745-6746 DT denotes a
T3213 6755-6764 NN denotes component
T3214 6747-6754 JJ denotes primary
T3215 6765-6767 IN denotes of
T3216 6768-6772 DT denotes this
T3217 6773-6781 NN denotes spectrum
T3218 6782-6784 IN denotes of
T3219 6785-6794 NNS denotes disorders
T3220 6794-6795 . denotes .
T5356 6806-6820 NN denotes Identification
T5357 6821-6823 IN denotes of
T5358 6824-6827 DT denotes the
T5359 6840-6848 NN denotes Mutation
T5360 6828-6834 JJ denotes little
T5361 6835-6839 NN denotes lung
T5362 6849-6851 IN denotes in
T5363 6852-6856 NN denotes Fog2
T5364 6856-6991 sentence denotes We screened third-generation progeny of ENU-mutagenized mice at embryonic day 18.5 (E18.5) for abnormal developmental phenotypes [14].
T5365 6857-6859 PRP denotes We
T5366 6860-6868 VBD denotes screened
T5367 6869-6874 JJ denotes third
T5368 6875-6885 NN denotes generation
T5369 6874-6875 HYPH denotes -
T5370 6886-6893 NN denotes progeny
T5371 6894-6896 IN denotes of
T5372 6897-6900 NN denotes ENU
T5373 6901-6912 VBN denotes mutagenized
T5374 6900-6901 HYPH denotes -
T5375 6913-6917 NNS denotes mice
T5376 6918-6920 IN denotes at
T5377 6921-6930 JJ denotes embryonic
T5378 6931-6934 NN denotes day
T5379 6935-6939 CD denotes 18.5
T5380 6940-6941 -LRB- denotes (
T5381 6941-6946 NN denotes E18.5
T5382 6946-6947 -RRB- denotes )
T5383 6948-6951 IN denotes for
T5384 6952-6960 JJ denotes abnormal
T5385 6975-6985 NNS denotes phenotypes
T5386 6961-6974 JJ denotes developmental
T5387 6986-6987 -LRB- denotes [
T5388 6987-6989 CD denotes 14
T5389 6989-6990 -RRB- denotes ]
T5390 6990-6991 . denotes .
T5391 6991-7124 sentence denotes One line of mice was found to have multiple embryos in independent litters that displayed pulmonary hypoplasia and a thin diaphragm.
T5392 6992-6995 CD denotes One
T5393 6996-7000 NN denotes line
T5394 7013-7018 VBN denotes found
T5395 7001-7003 IN denotes of
T5396 7004-7008 NNS denotes mice
T5397 7009-7012 VBD denotes was
T5398 7019-7021 TO denotes to
T5399 7022-7026 VB denotes have
T5400 7027-7035 JJ denotes multiple
T5401 7036-7043 NNS denotes embryos
T5402 7044-7046 IN denotes in
T5403 7047-7058 JJ denotes independent
T5404 7059-7066 NNS denotes litters
T5405 7067-7071 WDT denotes that
T5406 7072-7081 VBD denotes displayed
T5407 7082-7091 JJ denotes pulmonary
T5408 7092-7102 NN denotes hypoplasia
T5409 7103-7106 CC denotes and
T5410 7107-7108 DT denotes a
T5411 7114-7123 NN denotes diaphragm
T5412 7109-7113 JJ denotes thin
T5413 7123-7124 . denotes .
T5414 7124-7279 sentence denotes The mutation, which we called little lung (lil), was mapped to Chromosome 15 by utilizing a strategy of interval haplotype analysis (data not shown) [15].
T5415 7125-7128 DT denotes The
T5416 7129-7137 NN denotes mutation
T5417 7178-7184 VBN denotes mapped
T5418 7137-7139 , denotes ,
T5419 7139-7144 WDT denotes which
T5420 7148-7154 VBD denotes called
T5421 7145-7147 PRP denotes we
T5422 7155-7161 JJ denotes little
T5423 7162-7166 NN denotes lung
T5424 7167-7168 -LRB- denotes (
T5425 7168-7171 NN denotes lil
T5426 7171-7172 -RRB- denotes )
T5427 7172-7174 , denotes ,
T5428 7174-7177 VBD denotes was
T5429 7185-7187 IN denotes to
T5430 7188-7198 NN denotes Chromosome
T5431 7199-7201 CD denotes 15
T5432 7202-7204 IN denotes by
T5433 7205-7214 VBG denotes utilizing
T5434 7215-7216 DT denotes a
T5435 7217-7225 NN denotes strategy
T5436 7226-7228 IN denotes of
T5437 7229-7237 JJ denotes interval
T5438 7248-7256 NN denotes analysis
T5439 7238-7247 NN denotes haplotype
T5440 7257-7258 -LRB- denotes (
T5441 7267-7272 VBN denotes shown
T5442 7258-7262 NNS denotes data
T5443 7263-7266 RB denotes not
T5444 7272-7273 -RRB- denotes )
T5445 7274-7275 -LRB- denotes [
T5446 7275-7277 CD denotes 15
T5447 7277-7278 -RRB- denotes ]
T5448 7278-7279 . denotes .
T5449 7279-7351 sentence denotes For high-resolution mapping, F2 progeny from two crosses were analyzed.
T5450 7280-7283 IN denotes For
T5451 7342-7350 VBN denotes analyzed
T5452 7284-7288 JJ denotes high
T5453 7289-7299 NN denotes resolution
T5454 7288-7289 HYPH denotes -
T5455 7300-7307 NN denotes mapping
T5456 7307-7309 , denotes ,
T5457 7309-7311 NN denotes F2
T5458 7312-7319 NN denotes progeny
T5459 7320-7324 IN denotes from
T5460 7325-7328 CD denotes two
T5461 7329-7336 NNS denotes crosses
T5462 7337-7341 VBD denotes were
T5463 7350-7351 . denotes .
T5464 7351-7516 sentence denotes In 450 progeny of an intercross of F1 (A/J × FVB/N) lil/+ mice, the interval containing the mutation was defined by 19 recombinants between D15Mit220 and D15Mit154.
T5465 7352-7354 IN denotes In
T5466 7457-7464 VBN denotes defined
T5467 7355-7358 CD denotes 450
T5468 7359-7366 NN denotes progeny
T5469 7367-7369 IN denotes of
T5470 7370-7372 DT denotes an
T5471 7373-7383 NN denotes intercross
T5472 7384-7386 IN denotes of
T5473 7387-7389 NN denotes F1
T5474 7410-7414 NNS denotes mice
T5475 7390-7391 -LRB- denotes (
T5476 7393-7394 NN denotes J
T5477 7391-7392 NN denotes A
T5478 7392-7393 SYM denotes /
T5479 7395-7396 SYM denotes ×
T5480 7397-7400 NN denotes FVB
T5481 7401-7402 NN denotes N
T5482 7400-7401 HYPH denotes /
T5483 7402-7403 -RRB- denotes )
T5484 7404-7407 NN denotes lil
T5485 7407-7408 HYPH denotes /
T5486 7408-7409 SYM denotes +
T5487 7414-7416 , denotes ,
T5488 7416-7419 DT denotes the
T5489 7420-7428 NN denotes interval
T5490 7429-7439 VBG denotes containing
T5491 7440-7443 DT denotes the
T5492 7444-7452 NN denotes mutation
T5493 7453-7456 VBD denotes was
T5494 7465-7467 IN denotes by
T5495 7468-7470 CD denotes 19
T5496 7471-7483 NNS denotes recombinants
T5497 7484-7491 IN denotes between
T5498 7492-7501 NN denotes D15Mit220
T5499 7502-7505 CC denotes and
T5500 7506-7515 NN denotes D15Mit154
T5501 7515-7516 . denotes .
T5502 7516-7651 sentence denotes Because of the lack of informative markers within this interval, an additional 39 F2 progeny from an A/J × C57BL/6J cross were tested.
T5503 7517-7524 IN denotes Because
T5504 7644-7650 VBN denotes tested
T5505 7525-7527 IN denotes of
T5506 7528-7531 DT denotes the
T5507 7532-7536 NN denotes lack
T5508 7537-7539 IN denotes of
T5509 7540-7551 JJ denotes informative
T5510 7552-7559 NNS denotes markers
T5511 7560-7566 IN denotes within
T5512 7567-7571 DT denotes this
T5513 7572-7580 NN denotes interval
T5514 7580-7582 , denotes ,
T5515 7582-7584 DT denotes an
T5516 7596-7598 CD denotes 39
T5517 7585-7595 JJ denotes additional
T5518 7602-7609 NN denotes progeny
T5519 7599-7601 NN denotes F2
T5520 7610-7614 IN denotes from
T5521 7615-7617 DT denotes an
T5522 7633-7638 NN denotes cross
T5523 7618-7619 NN denotes A
T5524 7620-7621 NN denotes J
T5525 7619-7620 HYPH denotes /
T5526 7622-7623 SYM denotes ×
T5527 7624-7629 NN denotes C57BL
T5528 7630-7632 NN denotes 6J
T5529 7629-7630 HYPH denotes /
T5530 7639-7643 VBD denotes were
T5531 7650-7651 . denotes .
T5532 7651-7771 sentence denotes The identification of two recombinants established D15Mit85 as the proximal and D15Mit5 as the distal flanking markers.
T5533 7652-7655 DT denotes The
T5534 7656-7670 NN denotes identification
T5535 7691-7702 VBD denotes established
T5536 7671-7673 IN denotes of
T5537 7674-7677 CD denotes two
T5538 7678-7690 NNS denotes recombinants
T5539 7703-7711 NN denotes D15Mit85
T5540 7712-7714 IN denotes as
T5541 7715-7718 DT denotes the
T5542 7719-7727 JJ denotes proximal
T5543 7728-7731 CC denotes and
T5544 7732-7739 NN denotes D15Mit5
T5545 7740-7742 IN denotes as
T5546 7743-7746 DT denotes the
T5547 7747-7753 JJ denotes distal
T5548 7754-7762 NN denotes flanking
T5549 7763-7770 NNS denotes markers
T5550 7770-7771 . denotes .
T5551 7771-7879 sentence denotes The lil phenotype was identified at E18.5 to have bilateral pulmonary hypoplasia and an abnormal diaphragm.
T5552 7772-7775 DT denotes The
T5553 7780-7789 NN denotes phenotype
T5554 7776-7779 NN denotes lil
T5555 7794-7804 VBN denotes identified
T5556 7790-7793 VBD denotes was
T5557 7805-7807 IN denotes at
T5558 7808-7813 NN denotes E18.5
T5559 7814-7816 TO denotes to
T5560 7817-7821 VB denotes have
T5561 7822-7831 JJ denotes bilateral
T5562 7842-7852 NN denotes hypoplasia
T5563 7832-7841 JJ denotes pulmonary
T5564 7853-7856 CC denotes and
T5565 7857-7859 DT denotes an
T5566 7869-7878 NN denotes diaphragm
T5567 7860-7868 JJ denotes abnormal
T5568 7878-7879 . denotes .
T5569 7879-7956 sentence denotes Pulmonary hypoplasia was apparent in all mutant mice that survived to birth.
T5570 7880-7889 JJ denotes Pulmonary
T5571 7890-7900 NN denotes hypoplasia
T5572 7901-7904 VBD denotes was
T5573 7905-7913 JJ denotes apparent
T5574 7914-7916 IN denotes in
T5575 7917-7920 DT denotes all
T5576 7928-7932 NNS denotes mice
T5577 7921-7927 NN denotes mutant
T5578 7933-7937 WDT denotes that
T5579 7938-7946 VBD denotes survived
T5580 7947-7949 IN denotes to
T5581 7950-7955 NN denotes birth
T5582 7955-7956 . denotes .
T5583 7956-8141 sentence denotes In a comparison between wild-type and mutant mice found dead on day one of life, body weights were not different; however, the lung weights were significantly lower in the mutant mice.
T5584 7957-7959 IN denotes In
T5585 8097-8101 VBD denotes were
T5586 7960-7961 DT denotes a
T5587 7962-7972 NN denotes comparison
T5588 7973-7980 IN denotes between
T5589 7981-7985 JJ denotes wild
T5590 7986-7990 NN denotes type
T5591 7985-7986 HYPH denotes -
T5592 8002-8006 NNS denotes mice
T5593 7991-7994 CC denotes and
T5594 7995-8001 NN denotes mutant
T5595 8007-8012 VBN denotes found
T5596 8013-8017 JJ denotes dead
T5597 8018-8020 IN denotes on
T5598 8021-8024 NN denotes day
T5599 8025-8028 CD denotes one
T5600 8029-8031 IN denotes of
T5601 8032-8036 NN denotes life
T5602 8036-8038 , denotes ,
T5603 8038-8042 NN denotes body
T5604 8043-8050 NNS denotes weights
T5605 8051-8055 VBD denotes were
T5606 8056-8059 RB denotes not
T5607 8060-8069 JJ denotes different
T5608 8069-8070 : denotes ;
T5609 8071-8078 RB denotes however
T5610 8078-8080 , denotes ,
T5611 8080-8083 DT denotes the
T5612 8089-8096 NNS denotes weights
T5613 8084-8088 NN denotes lung
T5614 8102-8115 RB denotes significantly
T5615 8116-8121 JJR denotes lower
T5616 8122-8124 IN denotes in
T5617 8125-8128 DT denotes the
T5618 8136-8140 NNS denotes mice
T5619 8129-8135 NN denotes mutant
T5620 8140-8141 . denotes .
T5621 8141-8260 sentence denotes The average mutant lung weight was 9.6 ± 2.5 mg while the average wild-type lung weight was 26.4 ± 4.6 mg (p < 0.001).
T5622 8142-8145 DT denotes The
T5623 8166-8172 NN denotes weight
T5624 8146-8153 JJ denotes average
T5625 8154-8160 NN denotes mutant
T5626 8161-8165 NN denotes lung
T5627 8173-8176 VBD denotes was
T5628 8177-8180 CD denotes 9.6
T5629 8183-8186 CD denotes 2.5
T5630 8181-8182 SYM denotes ±
T5631 8187-8189 NN denotes mg
T5632 8190-8195 IN denotes while
T5633 8230-8233 VBD denotes was
T5634 8196-8199 DT denotes the
T5635 8223-8229 NN denotes weight
T5636 8200-8207 JJ denotes average
T5637 8208-8212 JJ denotes wild
T5638 8213-8217 NN denotes type
T5639 8212-8213 HYPH denotes -
T5640 8218-8222 NN denotes lung
T5641 8234-8238 CD denotes 26.4
T5642 8241-8244 CD denotes 4.6
T5643 8239-8240 SYM denotes ±
T5644 8245-8247 NN denotes mg
T5645 8248-8249 -LRB- denotes (
T5646 8253-8258 CD denotes 0.001
T5647 8249-8250 NN denotes p
T5648 8251-8252 SYM denotes <
T5649 8258-8259 -RRB- denotes )
T5650 8259-8260 . denotes .
T5651 8260-8408 sentence denotes All lungs from mutant mice were lacking an accessory lobe on the right side and had underdevelopment of the anterior right middle lobe (Figure 1A).
T5652 8261-8264 DT denotes All
T5653 8265-8270 NNS denotes lungs
T5654 8293-8300 VBG denotes lacking
T5655 8271-8275 IN denotes from
T5656 8276-8282 NN denotes mutant
T5657 8283-8287 NNS denotes mice
T5658 8288-8292 VBD denotes were
T5659 8301-8303 DT denotes an
T5660 8314-8318 NN denotes lobe
T5661 8304-8313 JJ denotes accessory
T5662 8319-8321 IN denotes on
T5663 8322-8325 DT denotes the
T5664 8332-8336 NN denotes side
T5665 8326-8331 JJ denotes right
T5666 8337-8340 CC denotes and
T5667 8341-8344 VBD denotes had
T5668 8345-8361 NN denotes underdevelopment
T5669 8362-8364 IN denotes of
T5670 8365-8368 DT denotes the
T5671 8391-8395 NN denotes lobe
T5672 8369-8377 JJ denotes anterior
T5673 8378-8383 JJ denotes right
T5674 8384-8390 JJ denotes middle
T5675 8396-8397 -LRB- denotes (
T5676 8397-8403 NN denotes Figure
T5677 8404-8406 CD denotes 1A
T5678 8406-8407 -RRB- denotes )
T5679 8407-8408 . denotes .
T5680 8408-8507 sentence denotes Diaphragms from mutant lil mice were intact, but muscularization was absent in the dorsal regions.
T5681 8409-8419 NNS denotes Diaphragms
T5682 8441-8445 VBD denotes were
T5683 8420-8424 IN denotes from
T5684 8425-8431 NN denotes mutant
T5685 8436-8440 NNS denotes mice
T5686 8432-8435 NN denotes lil
T5687 8446-8452 JJ denotes intact
T5688 8452-8454 , denotes ,
T5689 8454-8457 CC denotes but
T5690 8458-8473 NN denotes muscularization
T5691 8474-8477 VBD denotes was
T5692 8478-8484 JJ denotes absent
T5693 8485-8487 IN denotes in
T5694 8488-8491 DT denotes the
T5695 8499-8506 NNS denotes regions
T5696 8492-8498 JJ denotes dorsal
T5697 8506-8507 . denotes .
T5698 8507-8571 sentence denotes Myotubules were present in a limited and abnormal distribution.
T5699 8508-8518 NNS denotes Myotubules
T5700 8519-8523 VBD denotes were
T5701 8524-8531 JJ denotes present
T5702 8532-8534 IN denotes in
T5703 8535-8536 DT denotes a
T5704 8558-8570 NN denotes distribution
T5705 8537-8544 JJ denotes limited
T5706 8545-8548 CC denotes and
T5707 8549-8557 JJ denotes abnormal
T5708 8570-8571 . denotes .
T5709 8571-8748 sentence denotes More specifically, myotubules normally radiate in a mediolateral fashion to meet the lateral body walls, with a normal paucity of muscle fibers in the central tendonous region.
T5710 8572-8576 RBR denotes More
T5711 8577-8589 RB denotes specifically
T5712 8611-8618 VBP denotes radiate
T5713 8589-8591 , denotes ,
T5714 8591-8601 NNS denotes myotubules
T5715 8602-8610 RB denotes normally
T5716 8619-8621 IN denotes in
T5717 8622-8623 DT denotes a
T5718 8637-8644 NN denotes fashion
T5719 8624-8636 JJ denotes mediolateral
T5720 8645-8647 TO denotes to
T5721 8648-8652 VB denotes meet
T5722 8653-8656 DT denotes the
T5723 8670-8675 NNS denotes walls
T5724 8657-8664 JJ denotes lateral
T5725 8665-8669 NN denotes body
T5726 8675-8677 , denotes ,
T5727 8677-8681 IN denotes with
T5728 8682-8683 DT denotes a
T5729 8691-8698 NN denotes paucity
T5730 8684-8690 JJ denotes normal
T5731 8699-8701 IN denotes of
T5732 8702-8708 NN denotes muscle
T5733 8709-8715 NNS denotes fibers
T5734 8716-8718 IN denotes in
T5735 8719-8722 DT denotes the
T5736 8741-8747 NN denotes region
T5737 8723-8730 JJ denotes central
T5738 8731-8740 JJ denotes tendonous
T5739 8747-8748 . denotes .
T5740 8748-8907 sentence denotes In the mutant diaphragm, myotubules radiated in a dorsal–ventral orientation, and muscle tissue did not meet the entire surface of the body walls (Figure 1B).
T5741 8749-8751 IN denotes In
T5742 8785-8793 VBN denotes radiated
T5743 8752-8755 DT denotes the
T5744 8763-8772 NN denotes diaphragm
T5745 8756-8762 NN denotes mutant
T5746 8772-8774 , denotes ,
T5747 8774-8784 NNS denotes myotubules
T5748 8794-8796 IN denotes in
T5749 8797-8798 DT denotes a
T5750 8814-8825 NN denotes orientation
T5751 8799-8805 JJ denotes dorsal
T5752 8806-8813 JJ denotes ventral
T5753 8805-8806 HYPH denotes –
T5754 8825-8827 , denotes ,
T5755 8827-8830 CC denotes and
T5756 8831-8837 NN denotes muscle
T5757 8838-8844 NN denotes tissue
T5758 8853-8857 VB denotes meet
T5759 8845-8848 VBD denotes did
T5760 8849-8852 RB denotes not
T5869 9855-9868 RB denotes progressively
T5870 9869-9875 JJR denotes higher
T5871 9881-9883 IN denotes of
T5872 9884-9890 NN denotes demise
T5873 9891-9898 IN denotes between
T5874 9899-9904 NN denotes E13.5
T5875 9905-9908 CC denotes and
T5876 9909-9914 NN denotes E15.5
T5877 9914-9915 . denotes .
T5878 9915-10012 sentence denotes At E12.5, 20 out of 87 (23%) were homozygous for the mutation, and all of these appeared viable.
T5879 9916-9918 IN denotes At
T5880 9945-9949 VBD denotes were
T5881 9919-9924 NN denotes E12.5
T5882 9924-9926 , denotes ,
T5883 9926-9928 CD denotes 20
T5884 9936-9938 CD denotes 87
T5885 9929-9932 IN denotes out
T5886 9933-9935 IN denotes of
T5887 9939-9940 -LRB- denotes (
T5888 9942-9943 NN denotes %
T5889 9940-9942 CD denotes 23
T5890 9943-9944 -RRB- denotes )
T5891 9950-9960 JJ denotes homozygous
T5892 9961-9964 IN denotes for
T5893 9965-9968 DT denotes the
T5894 9969-9977 NN denotes mutation
T5895 9977-9979 , denotes ,
T5896 9979-9982 CC denotes and
T5897 9983-9986 DT denotes all
T5898 9996-10004 VBD denotes appeared
T5899 9987-9989 IN denotes of
T5900 9990-9995 DT denotes these
T5901 10005-10011 JJ denotes viable
T5902 10011-10012 . denotes .
T5903 10012-10067 sentence denotes At E13.5, 13 of 49 (27%) were mutant and two had died.
T5904 10013-10015 IN denotes At
T5905 10038-10042 VBD denotes were
T5906 10016-10021 NN denotes E13.5
T5907 10021-10023 , denotes ,
T5908 10023-10025 CD denotes 13
T5909 10029-10031 CD denotes 49
T5910 10026-10028 IN denotes of
T5911 10032-10033 -LRB- denotes (
T5912 10035-10036 NN denotes %
T5913 10033-10035 CD denotes 27
T5914 10036-10037 -RRB- denotes )
T5915 10043-10049 JJ denotes mutant
T5916 10050-10053 CC denotes and
T5917 10054-10057 CD denotes two
T5918 10062-10066 VBN denotes died
T5919 10058-10061 VBD denotes had
T5920 10066-10067 . denotes .
T5921 10067-10172 sentence denotes At E15.5, 22 out of 91 (24%) were mutant and the majority of mutant embryos (17 out of the 22) had died.
T5922 10068-10070 IN denotes At
T5923 10097-10101 VBD denotes were
T5924 10071-10076 NN denotes E15.5
T5925 10076-10078 , denotes ,
T5926 10078-10080 CD denotes 22
T5927 10088-10090 CD denotes 91
T5928 10081-10084 IN denotes out
T5929 10085-10087 IN denotes of
T5930 10091-10092 -LRB- denotes (
T5931 10094-10095 NN denotes %
T5932 10092-10094 CD denotes 24
T5933 10095-10096 -RRB- denotes )
T5934 10102-10108 JJ denotes mutant
T5935 10109-10112 CC denotes and
T5936 10113-10116 DT denotes the
T5937 10117-10125 NN denotes majority
T5938 10167-10171 VBN denotes died
T5939 10126-10128 IN denotes of
T5940 10129-10135 NN denotes mutant
T5941 10136-10143 NNS denotes embryos
T5942 10144-10145 -LRB- denotes (
T5943 10159-10161 CD denotes 22
T5944 10145-10147 CD denotes 17
T5945 10148-10151 IN denotes out
T5946 10152-10154 IN denotes of
T5947 10155-10158 DT denotes the
T5948 10161-10162 -RRB- denotes )
T5949 10163-10166 VBD denotes had
T5950 10171-10172 . denotes .
T5951 10172-10278 sentence denotes By E18.5, nine of 29 embryos (31%) were homozygous for the mutation, of which only one embryo was viable.
T5952 10173-10175 IN denotes By
T5953 10208-10212 VBD denotes were
T5954 10176-10181 NN denotes E18.5
T5955 10181-10183 , denotes ,
T5956 10183-10187 CD denotes nine
T5957 10191-10193 CD denotes 29
T5958 10188-10190 IN denotes of
T5959 10194-10201 NNS denotes embryos
T5960 10202-10203 -LRB- denotes (
T5961 10205-10206 NN denotes %
T5962 10203-10205 CD denotes 31
T5963 10206-10207 -RRB- denotes )
T5964 10213-10223 JJ denotes homozygous
T5965 10224-10227 IN denotes for
T5966 10228-10231 DT denotes the
T5967 10232-10240 NN denotes mutation
T5968 10240-10242 , denotes ,
T5969 10242-10244 IN denotes of
T5970 10267-10270 VBD denotes was
T5971 10245-10250 WDT denotes which
T5972 10251-10255 RB denotes only
T5973 10260-10266 NN denotes embryo
T5974 10256-10259 CD denotes one
T5975 10271-10277 JJ denotes viable
T5976 10277-10278 . denotes .
T5977 10278-10359 sentence denotes Diaphragmatic muscularization was abnormal in all mutant mice examined (n > 25).
T5978 10279-10292 JJ denotes Diaphragmatic
T5979 10293-10308 NN denotes muscularization
T5980 10309-10312 VBD denotes was
T5981 10313-10321 JJ denotes abnormal
T5982 10322-10324 IN denotes in
T5983 10325-10328 DT denotes all
T5984 10336-10340 NNS denotes mice
T5985 10329-10335 NN denotes mutant
T5986 10341-10349 VBN denotes examined
T5987 10350-10351 -LRB- denotes (
T5988 10355-10357 CD denotes 25
T5989 10351-10352 NN denotes n
T5990 10353-10354 SYM denotes >
T5991 10357-10358 -RRB- denotes )
T5992 10358-10359 . denotes .
T5993 10359-10475 sentence denotes Pulmonary hypoplasia was observed in 100% of mutants evaluated for that phenotype between E11.5 and birth (n > 50).
T5994 10360-10369 JJ denotes Pulmonary
T5995 10370-10380 NN denotes hypoplasia
T5996 10385-10393 VBN denotes observed
T5997 10381-10384 VBD denotes was
T5998 10394-10396 IN denotes in
T5999 10397-10400 CD denotes 100
T6000 10400-10401 NN denotes %
T6001 10402-10404 IN denotes of
T6002 10405-10412 NNS denotes mutants
T6003 10413-10422 VBN denotes evaluated
T6004 10423-10426 IN denotes for
T6005 10427-10431 DT denotes that
T6006 10432-10441 NN denotes phenotype
T6007 10442-10449 IN denotes between
T6008 10450-10455 NN denotes E11.5
T6009 10456-10459 CC denotes and
T6010 10460-10465 NN denotes birth
T6011 10466-10467 -LRB- denotes (
T6012 10471-10473 CD denotes 50
T6013 10467-10468 NN denotes n
T6014 10469-10470 SYM denotes >
T6015 10473-10474 -RRB- denotes )
T6016 10474-10475 . denotes .
T6017 10475-10733 sentence denotes Examination of cardiac morphology showed that hearts from E15.5 lil mutant mice had a variety of developmental defects, including enlarged and abnormally developed endocardial cushions, a double-outlet right ventricle, and a complete atrioventricular canal.
T6018 10476-10487 NN denotes Examination
T6019 10510-10516 VBD denotes showed
T6020 10488-10490 IN denotes of
T6021 10491-10498 JJ denotes cardiac
T6022 10499-10509 NN denotes morphology
T6023 10517-10521 IN denotes that
T6024 10556-10559 VBD denotes had
T6025 10522-10528 NNS denotes hearts
T6026 10529-10533 IN denotes from
T6027 10534-10539 NN denotes E15.5
T6028 10551-10555 NNS denotes mice
T6029 10540-10543 NN denotes lil
T6030 10544-10550 NN denotes mutant
T6031 10560-10561 DT denotes a
T6032 10562-10569 NN denotes variety
T6033 10570-10572 IN denotes of
T6034 10573-10586 JJ denotes developmental
T6035 10587-10594 NNS denotes defects
T6036 10594-10596 , denotes ,
T6037 10596-10605 VBG denotes including
T6038 10606-10614 VBN denotes enlarged
T6039 10652-10660 NNS denotes cushions
T6040 10615-10618 CC denotes and
T6041 10619-10629 RB denotes abnormally
T6042 10630-10639 VBN denotes developed
T6043 10640-10651 JJ denotes endocardial
T6044 10660-10662 , denotes ,
T6045 10662-10663 DT denotes a
T6046 10684-10693 NN denotes ventricle
T6047 10664-10670 JJ denotes double
T6048 10671-10677 NN denotes outlet
T6049 10670-10671 HYPH denotes -
T6050 10678-10683 JJ denotes right
T6051 10693-10695 , denotes ,
T6052 10695-10698 CC denotes and
T6053 10699-10700 DT denotes a
T6054 10727-10732 NN denotes canal
T6055 10701-10709 JJ denotes complete
T6056 10710-10726 JJ denotes atrioventricular
T6057 10732-10733 . denotes .
T6058 10733-10843 sentence denotes The myocardium was also poorly developed, with thinning of the outer compact layer and decreased vascularity.
T6059 10734-10737 DT denotes The
T6060 10738-10748 NN denotes myocardium
T6061 10749-10752 VBD denotes was
T6062 10753-10757 RB denotes also
T6063 10758-10764 RB denotes poorly
T6064 10765-10774 VBN denotes developed
T6065 10774-10776 , denotes ,
T6066 10776-10780 IN denotes with
T6067 10781-10789 NN denotes thinning
T6068 10790-10792 IN denotes of
T6069 10793-10796 DT denotes the
T6070 10811-10816 NN denotes layer
T6071 10797-10802 JJ denotes outer
T6072 10803-10810 JJ denotes compact
T6073 10817-10820 CC denotes and
T6074 10821-10830 VBN denotes decreased
T6075 10831-10842 NN denotes vascularity
T6076 10842-10843 . denotes .
T6077 10843-11063 sentence denotes The cohort of mutant mice that survived to birth also had cardiac malformations including atrioventricular-canal-type ventricular septal defects, ostium primum atrial septal defects, and enlarged atria (data not shown).
T6078 10844-10847 DT denotes The
T6079 10848-10854 NN denotes cohort
T6080 10898-10901 VBD denotes had
T6081 10855-10857 IN denotes of
T6082 10858-10864 NN denotes mutant
T6083 10865-10869 NNS denotes mice
T6084 10870-10874 WDT denotes that
T6085 10875-10883 VBD denotes survived
T6086 10884-10886 IN denotes to
T6087 10887-10892 NN denotes birth
T6088 10893-10897 RB denotes also
T6089 10902-10909 JJ denotes cardiac
T6090 10910-10923 NNS denotes malformations
T6091 10924-10933 VBG denotes including
T6092 10934-10950 JJ denotes atrioventricular
T6093 10951-10956 NN denotes canal
T6094 10950-10951 HYPH denotes -
T6095 10957-10961 NN denotes type
T6096 10956-10957 HYPH denotes -
T6097 10981-10988 NNS denotes defects
T6098 10962-10973 JJ denotes ventricular
T6099 10974-10980 JJ denotes septal
T6100 10988-10990 , denotes ,
T6101 10990-10996 NN denotes ostium
T6102 11018-11025 NNS denotes defects
T6103 10997-11003 NN denotes primum
T6104 11004-11010 JJ denotes atrial
T6105 11011-11017 JJ denotes septal
T6106 11025-11027 , denotes ,
T6107 11027-11030 CC denotes and
T6108 11031-11039 VBN denotes enlarged
T6109 11040-11045 NNS denotes atria
T6110 11046-11047 -LRB- denotes (
T6111 11056-11061 VBN denotes shown
T6112 11047-11051 NNS denotes data
T6113 11052-11055 RB denotes not
T6114 11061-11062 -RRB- denotes )
T6115 11062-11063 . denotes .
T6116 11063-11165 sentence denotes All mutants specifically evaluated for a cardiac phenotype (n = 10) had abnormal cardiac development.
T6117 11064-11067 DT denotes All
T6118 11068-11075 NNS denotes mutants
T6119 11132-11135 VBD denotes had
T6120 11076-11088 RB denotes specifically
T6121 11089-11098 VBN denotes evaluated
T6122 11099-11102 IN denotes for
T6123 11103-11104 DT denotes a
T6124 11113-11122 NN denotes phenotype
T6125 11105-11112 JJ denotes cardiac
T6126 11123-11124 -LRB- denotes (
T6127 11128-11130 CD denotes 10
T6128 11124-11125 NN denotes n
T6129 11126-11127 SYM denotes =
T6130 11130-11131 -RRB- denotes )
T6131 11136-11144 JJ denotes abnormal
T6132 11153-11164 NN denotes development
T6133 11145-11152 JJ denotes cardiac
T6134 11164-11165 . denotes .
T6135 11165-11320 sentence denotes Examination of the 3-Mb region between D15Mit85 and D15Mit5 in DNA sequence databases revealed three predicted genes and four known genes, including Fog2.
T6136 11166-11177 NN denotes Examination
T6137 11252-11260 VBD denotes revealed
T6138 11178-11180 IN denotes of
T6139 11181-11184 DT denotes the
T6140 11190-11196 NN denotes region
T6141 11185-11186 CD denotes 3
T6142 11187-11189 NN denotes Mb
T6143 11186-11187 HYPH denotes -
T6144 11197-11204 IN denotes between
T6145 11205-11213 NN denotes D15Mit85
T6146 11214-11217 CC denotes and
T6147 11218-11225 NN denotes D15Mit5
T6148 11226-11228 IN denotes in
T6149 11229-11232 NN denotes DNA
T6150 11233-11241 NN denotes sequence
T6151 11242-11251 NNS denotes databases
T6152 11261-11266 CD denotes three
T6153 11277-11282 NNS denotes genes
T6154 11267-11276 VBN denotes predicted
T6155 11283-11286 CC denotes and
T6156 11287-11291 CD denotes four
T6157 11298-11303 NNS denotes genes
T6158 11292-11297 JJ denotes known
T6159 11303-11305 , denotes ,
T6160 11305-11314 VBG denotes including
T6161 11315-11319 NN denotes Fog2
T6162 11319-11320 . denotes .
T6163 11320-11530 sentence denotes Targeted mutations of Fog2 have cardiac defects strikingly similar to those we identified in lil mutant mice, including atrioventricular canal defects, thinned myocardium, and absent coronary vasculature [16].
T6164 11321-11329 VBN denotes Targeted
T6165 11330-11339 NNS denotes mutations
T6166 11348-11352 VBP denotes have
T6167 11340-11342 IN denotes of
T6168 11343-11347 NN denotes Fog2
T6169 11353-11360 JJ denotes cardiac
T6170 11361-11368 NNS denotes defects
T6171 11369-11379 RB denotes strikingly
T6172 11380-11387 JJ denotes similar
T6173 11388-11390 IN denotes to
T6174 11391-11396 DT denotes those
T6175 11397-11399 PRP denotes we
T6176 11400-11410 VBD denotes identified
T6177 11411-11413 IN denotes in
T6178 11414-11417 NN denotes lil
T6179 11425-11429 NNS denotes mice
T6180 11418-11424 NN denotes mutant
T6181 11429-11431 , denotes ,
T6182 11431-11440 VBG denotes including
T6183 11441-11457 JJ denotes atrioventricular
T6184 11464-11471 NNS denotes defects
T6185 11458-11463 NN denotes canal
T6186 11471-11473 , denotes ,
T6187 11473-11480 VBN denotes thinned
T6188 11481-11491 NN denotes myocardium
T6189 11491-11493 , denotes ,
T6190 11493-11496 CC denotes and
T6191 11497-11503 JJ denotes absent
T6192 11513-11524 NN denotes vasculature
T6193 11504-11512 JJ denotes coronary
T6194 11525-11526 -LRB- denotes [
T6195 11526-11528 CD denotes 16
T6196 11528-11529 -RRB- denotes ]
T6197 11529-11530 . denotes .
T6198 11530-11672 sentence denotes RT-PCR amplification of the proximal portion of Fog2 revealed longer transcripts in the lil mutant than in the wild-type embryos (Figure 2A).
T6199 11531-11533 NN denotes RT
T6200 11534-11537 NN denotes PCR
T6201 11533-11534 HYPH denotes -
T6202 11538-11551 NN denotes amplification
T6203 11584-11592 VBD denotes revealed
T6204 11552-11554 IN denotes of
T6205 11555-11558 DT denotes the
T6206 11568-11575 NN denotes portion
T6207 11559-11567 JJ denotes proximal
T6208 11576-11578 IN denotes of
T6209 11579-11583 NN denotes Fog2
T6210 11593-11599 JJR denotes longer
T6211 11600-11611 NNS denotes transcripts
T6212 11612-11614 IN denotes in
T6213 11615-11618 DT denotes the
T6214 11623-11629 NN denotes mutant
T6215 11619-11622 NN denotes lil
T6216 11630-11634 IN denotes than
T6217 11635-11637 IN denotes in
T6218 11638-11641 DT denotes the
T6219 11647-11651 NN denotes type
T6220 11642-11646 JJ denotes wild
T6221 11646-11647 HYPH denotes -
T6222 11652-11659 NNS denotes embryos
T6223 11660-11661 -LRB- denotes (
T6224 11661-11667 NN denotes Figure
T6225 11668-11670 CD denotes 2A
T6226 11670-11671 -RRB- denotes )
T6227 11671-11672 . denotes .
T6228 11672-11850 sentence denotes Sequencing of the mutant transcript revealed a point mutation (from thymine to cytosine) 2 bp after position 301, which is in the splice donor site at the end of the third exon.
T6229 11673-11683 NN denotes Sequencing
T6230 11709-11717 VBD denotes revealed
T6231 11684-11686 IN denotes of
T6232 11687-11690 DT denotes the
T6233 11698-11708 NN denotes transcript
T6234 11691-11697 NN denotes mutant
T6235 11718-11719 DT denotes a
T6236 11726-11734 NN denotes mutation
T6237 11720-11725 NN denotes point
T6238 11735-11736 -LRB- denotes (
T6239 11736-11740 IN denotes from
T6240 11741-11748 NN denotes thymine
T6241 11749-11751 IN denotes to
T6242 11752-11760 NN denotes cytosine
T6243 11760-11761 -RRB- denotes )
T6244 11762-11763 CD denotes 2
T6245 11764-11766 NN denotes bp
T6246 11767-11772 IN denotes after
T6247 11773-11781 NN denotes position
T6248 11782-11785 CD denotes 301
T6249 11785-11787 , denotes ,
T6250 11787-11792 WDT denotes which
T6251 11793-11795 VBZ denotes is
T6252 11796-11798 IN denotes in
T6253 11799-11802 DT denotes the
T6254 11816-11820 NN denotes site
T6255 11803-11809 NN denotes splice
T6256 11810-11815 NN denotes donor
T6257 11821-11823 IN denotes at
T6258 11824-11827 DT denotes the
T6259 11828-11831 NN denotes end
T6260 11832-11834 IN denotes of
T6261 11835-11838 DT denotes the
T6262 11845-11849 NN denotes exon
T6263 11839-11844 JJ denotes third
T6264 11849-11850 . denotes .
T6265 11850-12070 sentence denotes This mutation causes a splicing defect that results in the insertion of 85 bp of intronic sequence into the mutant transcript, and introduces a stop codon that generates a severely truncated protein product (Figure 2B).
T6266 11851-11855 DT denotes This
T6267 11856-11864 NN denotes mutation
T6268 11865-11871 VBZ denotes causes
T6269 11872-11873 DT denotes a
T6270 11883-11889 NN denotes defect
T6271 11874-11882 NN denotes splicing
T6272 11890-11894 WDT denotes that
T6273 11895-11902 VBZ denotes results
T6274 11903-11905 IN denotes in
T6275 11906-11909 DT denotes the
T6276 11910-11919 NN denotes insertion
T6277 11920-11922 IN denotes of
T6278 11923-11925 CD denotes 85
T6279 11926-11928 NN denotes bp
T6280 11929-11931 IN denotes of
T6281 11932-11940 JJ denotes intronic
T6282 11941-11949 NN denotes sequence
T6283 11950-11954 IN denotes into
T6284 11955-11958 DT denotes the
T6285 11966-11976 NN denotes transcript
T6286 11959-11965 NN denotes mutant
T6287 11976-11978 , denotes ,
T6288 11978-11981 CC denotes and
T6289 11982-11992 VBZ denotes introduces
T6290 11993-11994 DT denotes a
T6291 12000-12005 NN denotes codon
T6292 11995-11999 NN denotes stop
T6293 12006-12010 WDT denotes that
T6294 12011-12020 VBZ denotes generates
T6295 12021-12022 DT denotes a
T6296 12050-12057 NN denotes product
T6297 12023-12031 RB denotes severely
T6298 12032-12041 VBN denotes truncated
T6299 12042-12049 NN denotes protein
T6300 12058-12059 -LRB- denotes (
T6301 12059-12065 NN denotes Figure
T6302 12066-12068 CD denotes 2B
T6303 12068-12069 -RRB- denotes )
T6304 12069-12070 . denotes .
T6305 12070-12183 sentence denotes Heterozygous lil mutant mice were crossed with a Fog2 +/− (null allele) mutant generated by gene targeting [16].
T6306 12071-12083 JJ denotes Heterozygous
T6307 12095-12099 NNS denotes mice
T6308 12084-12087 NN denotes lil
T6309 12088-12094 NN denotes mutant
T6310 12105-12112 VBN denotes crossed
T6311 12100-12104 VBD denotes were
T6312 12113-12117 IN denotes with
T6313 12118-12119 DT denotes a
T6314 12143-12149 NN denotes mutant
T6315 12120-12124 NN denotes Fog2
T6316 12125-12126 SYM denotes +
T6317 12126-12127 HYPH denotes /
T6318 12127-12128 SYM denotes −
T6319 12129-12130 -LRB- denotes (
T6320 12135-12141 NN denotes allele
T6321 12130-12134 JJ denotes null
T6322 12141-12142 -RRB- denotes )
T6323 12150-12159 VBN denotes generated
T6324 12160-12162 IN denotes by
T6325 12163-12167 NN denotes gene
T6326 12168-12177 NN denotes targeting
T6327 12178-12179 -LRB- denotes [
T6328 12179-12181 CD denotes 16
T6329 12181-12182 -RRB- denotes ]
T6330 12182-12183 . denotes .
T6331 12183-12309 sentence denotes Doubly heterozygous mice had an embryonic lethal phenotype; this failure to complement proves that lil is a mutation in Fog2.
T6332 12184-12190 RB denotes Doubly
T6333 12191-12203 JJ denotes heterozygous
T6334 12204-12208 NNS denotes mice
T6335 12209-12212 VBD denotes had
T6336 12271-12277 VBZ denotes proves
T6337 12213-12215 DT denotes an
T6338 12233-12242 NN denotes phenotype
T6339 12216-12225 JJ denotes embryonic
T6340 12226-12232 JJ denotes lethal
T6341 12242-12243 : denotes ;
T6342 12244-12248 DT denotes this
T6343 12249-12256 NN denotes failure
T6344 12257-12259 TO denotes to
T6345 12260-12270 VB denotes complement
T6346 12278-12282 IN denotes that
T6347 12287-12289 VBZ denotes is
T6348 12283-12286 NN denotes lil
T6349 12290-12291 DT denotes a
T6350 12292-12300 NN denotes mutation
T6351 12301-12303 IN denotes in
T6352 12304-12308 NN denotes Fog2
T6353 12308-12309 . denotes .
T6354 12309-12512 sentence denotes The variable phenotype of lil mice (relative to that found for the Fog2 null mutant) is likely due to the generation of a low level of normal transcript despite the presence of the splice site mutation.
T6355 12310-12313 DT denotes The
T6356 12323-12332 NN denotes phenotype
T6357 12314-12322 JJ denotes variable
T6358 12395-12397 VBZ denotes is
T6359 12333-12335 IN denotes of
T6360 12336-12339 NN denotes lil
T6361 12340-12344 NNS denotes mice
T6362 12345-12346 -LRB- denotes (
T6363 12346-12354 JJ denotes relative
T6364 12355-12357 IN denotes to
T6365 12358-12362 DT denotes that
T6366 12363-12368 VBN denotes found
T6367 12369-12372 IN denotes for
T6368 12373-12376 DT denotes the
T6369 12387-12393 NN denotes mutant
T6370 12377-12381 NN denotes Fog2
T6371 12382-12386 JJ denotes null
T6372 12393-12394 -RRB- denotes )
T6373 12398-12404 RB denotes likely
T6374 12405-12408 IN denotes due
T6375 12409-12411 IN denotes to
T6376 12412-12415 DT denotes the
T6377 12416-12426 NN denotes generation
T6378 12427-12429 IN denotes of
T6379 12430-12431 DT denotes a
T6380 12436-12441 NN denotes level
T6381 12432-12435 JJ denotes low
T6382 12442-12444 IN denotes of
T6383 12445-12451 JJ denotes normal
T6384 12452-12462 NN denotes transcript
T6385 12463-12470 IN denotes despite
T6386 12471-12474 DT denotes the
T6387 12475-12483 NN denotes presence
T6388 12484-12486 IN denotes of
T6389 12487-12490 DT denotes the
T6390 12503-12511 NN denotes mutation
T6391 12491-12497 NN denotes splice
T6392 12498-12502 NN denotes site
T6393 12511-12512 . denotes .
T8822 17580-17584 DT denotes this
T8121 12938-12942 NN denotes Lung
T8122 12957-12968 NN denotes Development
T8123 12943-12946 CC denotes and
T8124 12947-12956 NN denotes Diaphragm
T8125 12969-12971 IN denotes in
T8126 12972-12975 DT denotes the
T8127 12988-12993 NN denotes Mouse
T8128 12976-12980 NN denotes Fog2
T8129 12981-12987 NN denotes Mutant
T8130 12993-13093 sentence denotes Experiments were conducted to evaluate the role of Fog2 in pulmonary and diaphragmatic development.
T8131 12994-13005 NNS denotes Experiments
T8132 13011-13020 VBN denotes conducted
T8133 13006-13010 VBD denotes were
T8134 13021-13023 TO denotes to
T8135 13024-13032 VB denotes evaluate
T8136 13033-13036 DT denotes the
T8137 13037-13041 NN denotes role
T8138 13042-13044 IN denotes of
T8139 13045-13049 NN denotes Fog2
T8140 13050-13052 IN denotes in
T8141 13053-13062 JJ denotes pulmonary
T8142 13081-13092 NN denotes development
T8143 13063-13066 CC denotes and
T8144 13067-13080 JJ denotes diaphragmatic
T8145 13092-13093 . denotes .
T8146 13093-13236 sentence denotes The pulmonary phenotype is characterized by diffuse hypoplasia and specific loss of the accessory lobe and a portion of the right middle lobe.
T8147 13094-13097 DT denotes The
T8148 13108-13117 NN denotes phenotype
T8149 13098-13107 JJ denotes pulmonary
T8150 13121-13134 VBN denotes characterized
T8151 13118-13120 VBZ denotes is
T8152 13135-13137 IN denotes by
T8153 13138-13145 JJ denotes diffuse
T8154 13146-13156 NN denotes hypoplasia
T8155 13157-13160 CC denotes and
T8156 13161-13169 JJ denotes specific
T8157 13170-13174 NN denotes loss
T8158 13175-13177 IN denotes of
T8159 13178-13181 DT denotes the
T8160 13192-13196 NN denotes lobe
T8161 13182-13191 JJ denotes accessory
T8162 13197-13200 CC denotes and
T8163 13201-13202 DT denotes a
T8164 13203-13210 NN denotes portion
T8165 13211-13213 IN denotes of
T8166 13214-13217 DT denotes the
T8167 13231-13235 NN denotes lobe
T8168 13218-13223 JJ denotes right
T8169 13224-13230 JJ denotes middle
T8170 13235-13236 . denotes .
T8171 13236-13466 sentence denotes It is well established that abnormalities in either diaphragmatic development or fetal breathing can result in a secondary pulmonary hypoplasia, although loss of normal structure has never been documented in this context [17,18].
T8172 13237-13239 PRP denotes It
T8173 13240-13242 VBZ denotes is
T8174 13243-13247 RB denotes well
T8175 13248-13259 VBN denotes established
T8176 13260-13264 IN denotes that
T8177 13338-13344 VB denotes result
T8178 13265-13278 NNS denotes abnormalities
T8179 13279-13281 IN denotes in
T8180 13282-13288 CC denotes either
T8181 13303-13314 NN denotes development
T8182 13289-13302 JJ denotes diaphragmatic
T8183 13315-13317 CC denotes or
T8184 13318-13323 JJ denotes fetal
T8185 13324-13333 NN denotes breathing
T8186 13334-13337 MD denotes can
T8187 13345-13347 IN denotes in
T8188 13348-13349 DT denotes a
T8189 13370-13380 NN denotes hypoplasia
T8190 13350-13359 JJ denotes secondary
T8191 13360-13369 JJ denotes pulmonary
T8192 13380-13382 , denotes ,
T8193 13382-13390 IN denotes although
T8194 13431-13441 VBN denotes documented
T8195 13391-13395 NN denotes loss
T8196 13396-13398 IN denotes of
T8197 13399-13405 JJ denotes normal
T8198 13406-13415 NN denotes structure
T8199 13416-13419 VBZ denotes has
T8200 13420-13425 RB denotes never
T8201 13426-13430 VBN denotes been
T8202 13442-13444 IN denotes in
T8203 13445-13449 DT denotes this
T8204 13450-13457 NN denotes context
T8205 13458-13459 -LRB- denotes [
T8206 13462-13464 CD denotes 18
T8207 13459-13461 CD denotes 17
T8208 13461-13462 , denotes ,
T8209 13464-13465 -RRB- denotes ]
T8210 13465-13466 . denotes .
T8211 13466-13672 sentence denotes Fog2 is expressed diffusely in the pulmonary mesenchyme during the period of branching morphogenesis, while later expression is restricted to the smooth muscles of airways and pulmonary vessels (Figure 3).
T8212 13467-13471 NN denotes Fog2
T8213 13475-13484 VBN denotes expressed
T8214 13472-13474 VBZ denotes is
T8215 13485-13494 RB denotes diffusely
T8216 13495-13497 IN denotes in
T8217 13498-13501 DT denotes the
T8218 13512-13522 NN denotes mesenchyme
T8219 13502-13511 JJ denotes pulmonary
T8220 13523-13529 IN denotes during
T8221 13530-13533 DT denotes the
T8222 13534-13540 NN denotes period
T8223 13541-13543 IN denotes of
T8224 13544-13553 NN denotes branching
T8225 13554-13567 NN denotes morphogenesis
T8226 13567-13569 , denotes ,
T8227 13569-13574 IN denotes while
T8228 13595-13605 VBN denotes restricted
T8229 13575-13580 JJ denotes later
T8230 13581-13591 NN denotes expression
T8231 13592-13594 VBZ denotes is
T8232 13606-13608 IN denotes to
T8233 13609-13612 DT denotes the
T8234 13620-13627 NNS denotes muscles
T8235 13613-13619 JJ denotes smooth
T8236 13628-13630 IN denotes of
T8237 13631-13638 NNS denotes airways
T8238 13639-13642 CC denotes and
T8239 13643-13652 JJ denotes pulmonary
T8240 13653-13660 NNS denotes vessels
T8241 13661-13662 -LRB- denotes (
T8242 13662-13668 NN denotes Figure
T8243 13669-13670 CD denotes 3
T8244 13670-13671 -RRB- denotes )
T8245 13671-13672 . denotes .
T8246 13672-13898 sentence denotes This, and the observation that lungs appeared small on transverse sections evaluated prior to diaphragmatic muscularization or function, suggests that the pulmonary hypoplasia occurs independently of the diaphragmatic defect.
T8247 13673-13677 DT denotes This
T8248 13810-13818 VBZ denotes suggests
T8249 13677-13679 , denotes ,
T8250 13679-13682 CC denotes and
T8251 13683-13686 DT denotes the
T8252 13687-13698 NN denotes observation
T8253 13699-13703 IN denotes that
T8254 13710-13718 VBD denotes appeared
T8255 13704-13709 NNS denotes lungs
T8256 13719-13724 JJ denotes small
T8257 13725-13727 IN denotes on
T8258 13728-13738 JJ denotes transverse
T8259 13739-13747 NNS denotes sections
T8260 13748-13757 VBN denotes evaluated
T8261 13758-13763 JJ denotes prior
T8262 13764-13766 IN denotes to
T8263 13767-13780 JJ denotes diaphragmatic
T8264 13781-13796 NN denotes muscularization
T8265 13797-13799 CC denotes or
T8266 13800-13808 NN denotes function
T8267 13808-13810 , denotes ,
T8268 13819-13823 IN denotes that
T8269 13849-13855 VBZ denotes occurs
T8270 13824-13827 DT denotes the
T8271 13838-13848 NN denotes hypoplasia
T8272 13828-13837 JJ denotes pulmonary
T8273 13856-13869 RB denotes independently
T8274 13870-13872 IN denotes of
T8275 13873-13876 DT denotes the
T8276 13891-13897 NN denotes defect
T8277 13877-13890 JJ denotes diaphragmatic
T8278 13897-13898 . denotes .
T8279 13898-14035 sentence denotes To test this hypothesis, lungs were dissected from Fog2 −/− mice and littermate controls before the onset of fetal diaphragmatic motion.
T8280 13899-13901 TO denotes To
T8281 13902-13906 VB denotes test
T8282 13935-13944 VBN denotes dissected
T8283 13907-13911 DT denotes this
T8284 13912-13922 NN denotes hypothesis
T8285 13922-13924 , denotes ,
T8286 13924-13929 NNS denotes lungs
T8287 13930-13934 VBD denotes were
T8288 13945-13949 IN denotes from
T8289 13950-13954 NN denotes Fog2
T8290 13959-13963 NNS denotes mice
T8291 13955-13956 SYM denotes −
T8292 13956-13957 HYPH denotes /
T8293 13957-13958 SYM denotes −
T8294 13964-13967 CC denotes and
T8295 13968-13978 NN denotes littermate
T8296 13979-13987 NNS denotes controls
T8297 13988-13994 IN denotes before
T8298 13995-13998 DT denotes the
T8299 13999-14004 NN denotes onset
T8300 14005-14007 IN denotes of
T8301 14008-14013 JJ denotes fetal
T8302 14028-14034 NN denotes motion
T8303 14014-14027 JJ denotes diaphragmatic
T8304 14034-14035 . denotes .
T8305 14035-14167 sentence denotes Fog2 −/− mice were used for this experiment, as we wanted to avoid potential phenotypic variance from the lil hypomorphic mutation.
T8306 14036-14040 NN denotes Fog2
T8307 14045-14049 NNS denotes mice
T8308 14041-14042 SYM denotes −
T8309 14042-14043 HYPH denotes /
T8310 14043-14044 SYM denotes −
T8311 14055-14059 VBN denotes used
T8312 14050-14054 VBD denotes were
T8313 14060-14063 IN denotes for
T8314 14064-14068 DT denotes this
T8315 14069-14079 NN denotes experiment
T8316 14079-14081 , denotes ,
T8317 14081-14083 IN denotes as
T8318 14087-14093 VBD denotes wanted
T8319 14084-14086 PRP denotes we
T8320 14094-14096 TO denotes to
T8321 14097-14102 VB denotes avoid
T8322 14103-14112 JJ denotes potential
T8323 14124-14132 NN denotes variance
T8324 14113-14123 JJ denotes phenotypic
T8325 14133-14137 IN denotes from
T8326 14138-14141 DT denotes the
T8327 14158-14166 NN denotes mutation
T8328 14142-14145 NN denotes lil
T8329 14146-14157 JJ denotes hypomorphic
T8330 14166-14167 . denotes .
T8331 14167-14282 sentence denotes Lungs dissected at E12 from Fog2 −/− embryos were smaller in size and lacked the development of an accessory lobe.
T8332 14168-14173 NNS denotes Lungs
T8333 14213-14217 VBD denotes were
T8334 14174-14183 VBN denotes dissected
T8335 14184-14186 IN denotes at
T8336 14187-14190 NN denotes E12
T8337 14191-14195 IN denotes from
T8338 14196-14200 NN denotes Fog2
T8339 14205-14212 NNS denotes embryos
T8340 14201-14202 SYM denotes −
T8341 14202-14203 HYPH denotes /
T8342 14203-14204 SYM denotes −
T8343 14218-14225 JJR denotes smaller
T8344 14226-14228 IN denotes in
T8345 14229-14233 NN denotes size
T8346 14234-14237 CC denotes and
T8347 14238-14244 VBD denotes lacked
T8348 14245-14248 DT denotes the
T8349 14249-14260 NN denotes development
T8350 14261-14263 IN denotes of
T8351 14264-14266 DT denotes an
T8352 14277-14281 NN denotes lobe
T8353 14267-14276 JJ denotes accessory
T8354 14281-14282 . denotes .
T8355 14282-14497 sentence denotes In 11 viable Fog2− /− lung culture explants, there was never development of an accessory lobe, and the weights of mutant lungs cultured for 5 d were significantly lower than those of littermate controls (Figure 4).
T8356 14283-14285 IN denotes In
T8357 14334-14337 VBD denotes was
T8358 14286-14288 CD denotes 11
T8359 14318-14326 NNS denotes explants
T8360 14289-14295 JJ denotes viable
T8361 14296-14300 NN denotes Fog2
T8362 14300-14301 SYM denotes −
T8363 14302-14303 HYPH denotes /
T8364 14303-14304 SYM denotes −
T8365 14305-14309 NN denotes lung
T8366 14310-14317 NN denotes culture
T8367 14326-14328 , denotes ,
T8368 14328-14333 EX denotes there
T8369 14338-14343 RB denotes never
T8370 14344-14355 NN denotes development
T8371 14356-14358 IN denotes of
T8372 14359-14361 DT denotes an
T8373 14372-14376 NN denotes lobe
T8374 14362-14371 JJ denotes accessory
T8375 14376-14378 , denotes ,
T8376 14378-14381 CC denotes and
T8377 14382-14385 DT denotes the
T8378 14386-14393 NNS denotes weights
T8379 14427-14431 VBD denotes were
T8380 14394-14396 IN denotes of
T8381 14397-14403 NN denotes mutant
T8382 14404-14409 NNS denotes lungs
T8383 14410-14418 VBN denotes cultured
T8384 14419-14422 IN denotes for
T8385 14423-14424 CD denotes 5
T8386 14425-14426 NN denotes d
T8387 14432-14445 RB denotes significantly
T8388 14446-14451 JJR denotes lower
T8389 14452-14456 IN denotes than
T8390 14457-14462 DT denotes those
T8391 14463-14465 IN denotes of
T8392 14466-14476 NN denotes littermate
T8393 14477-14485 NNS denotes controls
T8394 14486-14487 -LRB- denotes (
T8395 14487-14493 NN denotes Figure
T8396 14494-14495 CD denotes 4
T8397 14495-14496 -RRB- denotes )
T8398 14496-14497 . denotes .
T8399 14497-14591 sentence denotes These data demonstrate that the pulmonary hypoplasia in Fog2 mutant mice is a primary defect.
T8400 14498-14503 DT denotes These
T8401 14504-14508 NNS denotes data
T8402 14509-14520 VBP denotes demonstrate
T8403 14521-14525 IN denotes that
T8404 14571-14573 VBZ denotes is
T8405 14526-14529 DT denotes the
T8406 14540-14550 NN denotes hypoplasia
T8407 14530-14539 JJ denotes pulmonary
T8408 14551-14553 IN denotes in
T8409 14554-14558 NN denotes Fog2
T8410 14566-14570 NNS denotes mice
T8411 14559-14565 NN denotes mutant
T8412 14574-14575 DT denotes a
T8413 14584-14590 NN denotes defect
T8414 14576-14583 JJ denotes primary
T8415 14590-14591 . denotes .
T8416 14591-15375 sentence denotes Figure 3 Fog2 Is Expressed in the Developing Lung and Diaphragm Fog2 is expressed in the diffuse pulmonary mesenchyme at E13.5 (A) (arrow shows mesenchyme) and is restricted to the bronchial and vascular smooth muscle (sm) at E16.5 (B). Fog2 is expressed diffusely in the developing diaphragm (Dia) both prior to (E11.5) (C) and after muscularization (E13.5) (D). Figure 4 Fog2 Is Necessary for Primary Lung Development Fog2 null lungs removed prior to diaphragmatic muscularization and grown in vitro show no accessory lobe development. Accessory lobe is labeled with black arrow in control littermate lungs. Branching in the unaffected lobes appeared to be delayed by 6–12 h, but all mutants developed an intricate branching pattern in the unaffected lobes after culture for 5 d.
T8417 15204-15213 NN denotes Branching
T8418 15238-15246 VBD denotes appeared
T8419 15214-15216 IN denotes in
T8420 15217-15220 DT denotes the
T8421 15232-15237 NNS denotes lobes
T8422 15221-15231 JJ denotes unaffected
T8423 15247-15249 TO denotes to
T8424 15253-15260 VBN denotes delayed
T8425 15250-15252 VB denotes be
T8426 15261-15263 IN denotes by
T8427 15264-15265 CD denotes 6
T8428 15266-15268 CD denotes 12
T8429 15265-15266 SYM denotes –
T8430 15269-15270 NN denotes h
T8431 15270-15272 , denotes ,
T8432 15272-15275 CC denotes but
T8433 15276-15279 DT denotes all
T8434 15280-15287 NNS denotes mutants
T8435 15288-15297 VBD denotes developed
T8436 15298-15300 DT denotes an
T8437 15321-15328 NN denotes pattern
T8438 15301-15310 JJ denotes intricate
T8439 15311-15320 NN denotes branching
T8440 15329-15331 IN denotes in
T8441 15332-15335 DT denotes the
T8442 15347-15352 NNS denotes lobes
T8443 15336-15346 JJ denotes unaffected
T8444 15353-15358 IN denotes after
T8445 15359-15366 NN denotes culture
T8446 15367-15370 IN denotes for
T8447 15371-15372 CD denotes 5
T8448 15373-15374 NN denotes d
T8449 15374-15375 . denotes .
T8450 15375-15641 sentence denotes Because the Fog2 phenotype is striking for specific lobar loss, the spatial pattern of Fog2 expression was evaluated in normal embryos during the period of early lobar establishment to determine whether Fog2 expression is specifically different at these lobar buds.
T8451 15376-15383 IN denotes Because
T8452 15403-15405 VBZ denotes is
T8453 15384-15387 DT denotes the
T8454 15393-15402 NN denotes phenotype
T8455 15388-15392 NN denotes Fog2
T8456 15483-15492 VBN denotes evaluated
T8457 15406-15414 JJ denotes striking
T8458 15415-15418 IN denotes for
T8459 15419-15427 JJ denotes specific
T8460 15434-15438 NN denotes loss
T8461 15428-15433 NN denotes lobar
T8462 15438-15440 , denotes ,
T8463 15440-15443 DT denotes the
T8464 15452-15459 NN denotes pattern
T8465 15444-15451 JJ denotes spatial
T8466 15460-15462 IN denotes of
T8467 15463-15467 NN denotes Fog2
T8468 15468-15478 NN denotes expression
T8469 15479-15482 VBD denotes was
T8470 15493-15495 IN denotes in
T8471 15496-15502 JJ denotes normal
T8472 15503-15510 NNS denotes embryos
T8473 15511-15517 IN denotes during
T8474 15518-15521 DT denotes the
T8475 15522-15528 NN denotes period
T8476 15529-15531 IN denotes of
T8477 15532-15537 JJ denotes early
T8478 15544-15557 NN denotes establishment
T8479 15538-15543 NN denotes lobar
T8480 15558-15560 TO denotes to
T8481 15561-15570 VB denotes determine
T8482 15571-15578 IN denotes whether
T8483 15595-15597 VBZ denotes is
T8484 15579-15583 NN denotes Fog2
T8485 15584-15594 NN denotes expression
T8486 15598-15610 RB denotes specifically
T8487 15611-15620 JJ denotes different
T8488 15621-15623 IN denotes at
T8489 15624-15629 DT denotes these
T8490 15636-15640 NNS denotes buds
T8491 15630-15635 NN denotes lobar
T8492 15640-15641 . denotes .
T8493 15641-15761 sentence denotes Expression was evaluated in mice carrying a lacZ gene incorporated into the Fog2 locus (S. Tevosian, unpublished data).
T8494 15642-15652 NN denotes Expression
T8495 15657-15666 VBN denotes evaluated
T8496 15653-15656 VBD denotes was
T8497 15667-15669 IN denotes in
T8498 15670-15674 NNS denotes mice
T8499 15675-15683 VBG denotes carrying
T8500 15684-15685 DT denotes a
T8501 15691-15695 NN denotes gene
T8502 15686-15690 NN denotes lacZ
T8503 15696-15708 VBN denotes incorporated
T8504 15709-15713 IN denotes into
T8505 15714-15717 DT denotes the
T8506 15723-15728 NN denotes locus
T8507 15718-15722 NN denotes Fog2
T8508 15729-15730 -LRB- denotes (
T8509 15730-15732 NNP denotes S.
T8510 15733-15741 NNP denotes Tevosian
T8511 15741-15743 , denotes ,
T8512 15743-15754 JJ denotes unpublished
T8513 15755-15759 NNS denotes data
T8514 15759-15760 -RRB- denotes )
T8515 15760-15761 . denotes .
T8516 15761-16012 sentence denotes In nine mice examined at E11.5, all lungs showed a specific enhancement of Fog2 expression in the mesenchyme surrounding the accessory bud and the right middle lobe bud, which are the lobes that do not develop normally in Fog2 mutant mice (Figure 5).
T8517 15762-15764 IN denotes In
T8518 15804-15810 VBD denotes showed
T8519 15765-15769 CD denotes nine
T8520 15770-15774 NNS denotes mice
T8521 15775-15783 VBN denotes examined
T8522 15784-15786 IN denotes at
T8523 15787-15792 NN denotes E11.5
T8524 15792-15794 , denotes ,
T8525 15794-15797 DT denotes all
T8526 15798-15803 NNS denotes lungs
T8527 15811-15812 DT denotes a
T8528 15822-15833 NN denotes enhancement
T8529 15813-15821 JJ denotes specific
T8530 15834-15836 IN denotes of
T8531 15837-15841 NN denotes Fog2
T8532 15842-15852 NN denotes expression
T8533 15853-15855 IN denotes in
T8534 15856-15859 DT denotes the
T8535 15860-15870 NN denotes mesenchyme
T8536 15871-15882 VBG denotes surrounding
T8537 15883-15886 DT denotes the
T8538 15897-15900 NN denotes bud
T8539 15887-15896 JJ denotes accessory
T8540 15901-15904 CC denotes and
T8541 15905-15908 DT denotes the
T8542 15927-15930 NN denotes bud
T8543 15909-15914 JJ denotes right
T8544 15915-15921 JJ denotes middle
T8545 15922-15926 NN denotes lobe
T8546 15930-15932 , denotes ,
T8547 15932-15937 WDT denotes which
T8548 15938-15941 VBP denotes are
T8549 15942-15945 DT denotes the
T8550 15946-15951 NNS denotes lobes
T8551 15952-15956 WDT denotes that
T8552 15964-15971 VB denotes develop
T8553 15957-15959 VBP denotes do
T8554 15960-15963 RB denotes not
T8555 15972-15980 RB denotes normally
T8556 15981-15983 IN denotes in
T8557 15984-15988 NN denotes Fog2
T8558 15996-16000 NNS denotes mice
T8559 15989-15995 NN denotes mutant
T8560 16001-16002 -LRB- denotes (
T8561 16002-16008 NN denotes Figure
T8562 16009-16010 CD denotes 5
T8563 16010-16011 -RRB- denotes )
T8564 16011-16012 . denotes .
T8565 16012-16144 sentence denotes By E12.5, expression was diffuse in the pulmonary mesenchyme, as was seen previously with in situ hybridization on tissue sections.
T8566 16013-16015 IN denotes By
T8567 16034-16037 VBD denotes was
T8568 16016-16021 NN denotes E12.5
T8569 16021-16023 , denotes ,
T8570 16023-16033 NN denotes expression
T8571 16038-16045 JJ denotes diffuse
T8572 16046-16048 IN denotes in
T8573 16049-16052 DT denotes the
T8574 16063-16073 NN denotes mesenchyme
T8575 16053-16062 JJ denotes pulmonary
T8576 16073-16075 , denotes ,
T8577 16075-16077 IN denotes as
T8578 16082-16086 VBN denotes seen
T8579 16078-16081 VBD denotes was
T8580 16087-16097 RB denotes previously
T8581 16098-16102 IN denotes with
T8582 16103-16105 FW denotes in
T8583 16106-16110 FW denotes situ
T8584 16111-16124 NN denotes hybridization
T8585 16125-16127 IN denotes on
T8586 16128-16134 NN denotes tissue
T8587 16135-16143 NNS denotes sections
T8588 16143-16144 . denotes .
T8589 16144-16526 sentence denotes Figure 5 Fog2 Expression in Embryonic Non-Mutant Lungs In embryonic non-mutant lungs, Fog2 is most highly expressed at the tips of the accessory (single arrows) and right middle lobes (double arrows) at E11.25 (A) and E11.75 (B), while expression is diffuse by E12.75 (C). Diaphragms from Fog2 lil mice show an intact membrane with a defect in muscular patterning (see Figure 1B).
T8590 16419-16429 NNS denotes Diaphragms
T8591 16449-16453 VBP denotes show
T8592 16430-16434 IN denotes from
T8593 16435-16439 NN denotes Fog2
T8594 16444-16448 NNS denotes mice
T8595 16440-16443 NN denotes lil
T8596 16454-16456 DT denotes an
T8597 16464-16472 NN denotes membrane
T8598 16457-16463 JJ denotes intact
T8599 16473-16477 IN denotes with
T8600 16478-16479 DT denotes a
T8601 16480-16486 NN denotes defect
T8602 16487-16489 IN denotes in
T8603 16490-16498 JJ denotes muscular
T8604 16499-16509 NN denotes patterning
T8605 16510-16511 -LRB- denotes (
T8606 16511-16514 VB denotes see
T8607 16515-16521 NN denotes Figure
T8608 16522-16524 CD denotes 1B
T8609 16524-16525 -RRB- denotes )
T8610 16525-16526 . denotes .
T8611 16526-16661 sentence denotes The membranous portion of the diaphragm is populated by a migratory population of muscle precursor cells, much like the limbs [19,20].
T8612 16527-16530 DT denotes The
T8613 16542-16549 NN denotes portion
T8614 16531-16541 JJ denotes membranous
T8615 16570-16579 VBN denotes populated
T8616 16550-16552 IN denotes of
T8617 16553-16556 DT denotes the
T8618 16557-16566 NN denotes diaphragm
T8619 16567-16569 VBZ denotes is
T8620 16580-16582 IN denotes by
T8621 16583-16584 DT denotes a
T8622 16595-16605 NN denotes population
T8623 16585-16594 JJ denotes migratory
T8624 16606-16608 IN denotes of
T8625 16609-16615 NN denotes muscle
T8626 16626-16631 NNS denotes cells
T8627 16616-16625 NN denotes precursor
T8628 16631-16633 , denotes ,
T8629 16633-16637 RB denotes much
T8630 16638-16642 IN denotes like
T8631 16643-16646 DT denotes the
T8632 16647-16652 NNS denotes limbs
T8633 16653-16654 -LRB- denotes [
T8634 16657-16659 CD denotes 20
T8635 16654-16656 CD denotes 19
T8636 16656-16657 , denotes ,
T8637 16659-16660 -RRB- denotes ]
T8638 16660-16661 . denotes .
T8639 16661-16791 sentence denotes Mice with defects in genes known to be important for the control of this process have intact but amuscular diaphragms [17,21,22].
T8640 16662-16666 NNS denotes Mice
T8641 16743-16747 VBP denotes have
T8642 16667-16671 IN denotes with
T8643 16672-16679 NNS denotes defects
T8644 16680-16682 IN denotes in
T8645 16683-16688 NNS denotes genes
T8646 16689-16694 VBN denotes known
T8647 16695-16697 TO denotes to
T8648 16698-16700 VB denotes be
T8649 16701-16710 JJ denotes important
T8650 16711-16714 IN denotes for
T8651 16715-16718 DT denotes the
T8652 16719-16726 NN denotes control
T8653 16727-16729 IN denotes of
T8654 16730-16734 DT denotes this
T8655 16735-16742 NN denotes process
T8656 16748-16754 JJ denotes intact
T8657 16769-16779 NNS denotes diaphragms
T8658 16755-16758 CC denotes but
T8659 16759-16768 JJ denotes amuscular
T8660 16780-16781 -LRB- denotes [
T8661 16787-16789 CD denotes 22
T8662 16781-16783 CD denotes 17
T8663 16783-16784 , denotes ,
T8664 16784-16786 CD denotes 21
T8665 16786-16787 , denotes ,
T8666 16789-16790 -RRB- denotes ]
T8667 16790-16791 . denotes .
T8668 16791-16943 sentence denotes Hepatocyte growth factor/Scatter factor (HGF) is one potential candidate responsible for the guidance of muscle precursors to the membranous diaphragm.
T8669 16792-16802 NN denotes Hepatocyte
T8670 16810-16816 NN denotes factor
T8671 16803-16809 NN denotes growth
T8672 16838-16840 VBZ denotes is
T8673 16816-16817 HYPH denotes /
T8674 16817-16824 NN denotes Scatter
T8675 16825-16831 NN denotes factor
T8676 16832-16833 -LRB- denotes (
T8677 16833-16836 NN denotes HGF
T8678 16836-16837 -RRB- denotes )
T8679 16841-16844 CD denotes one
T8680 16855-16864 NN denotes candidate
T8681 16845-16854 JJ denotes potential
T8682 16865-16876 JJ denotes responsible
T8683 16877-16880 IN denotes for
T8684 16881-16884 DT denotes the
T8685 16885-16893 NN denotes guidance
T8686 16894-16896 IN denotes of
T8687 16897-16903 NN denotes muscle
T8688 16904-16914 NNS denotes precursors
T8689 16915-16917 IN denotes to
T8690 16918-16921 DT denotes the
T8691 16933-16942 NN denotes diaphragm
T8692 16922-16932 JJ denotes membranous
T8693 16942-16943 . denotes .
T8694 16943-17166 sentence denotes It has been shown that HGF is expressed along this anatomic pathway [23], and mice with absence of the HGF receptor c-Met fail to form muscularized pleuroperitoneal folds (PPFs), and thus have amuscular diaphragms [24,25].
T8695 16944-16946 PRP denotes It
T8696 16956-16961 VBN denotes shown
T8697 16947-16950 VBZ denotes has
T8698 16951-16955 VBN denotes been
T8699 16962-16966 IN denotes that
T8700 16974-16983 VBN denotes expressed
T8701 16967-16970 NN denotes HGF
T8702 16971-16973 VBZ denotes is
T8703 16984-16989 IN denotes along
T8704 16990-16994 DT denotes this
T8705 17004-17011 NN denotes pathway
T8706 16995-17003 JJ denotes anatomic
T8707 17012-17013 -LRB- denotes [
T8708 17013-17015 CD denotes 23
T8709 17015-17016 -RRB- denotes ]
T8710 17016-17018 , denotes ,
T8711 17018-17021 CC denotes and
T8712 17022-17026 NNS denotes mice
T8713 17066-17070 VBP denotes fail
T8714 17027-17031 IN denotes with
T8715 17032-17039 NN denotes absence
T8716 17040-17042 IN denotes of
T8717 17043-17046 DT denotes the
T8718 17051-17059 NN denotes receptor
T8719 17047-17050 NN denotes HGF
T8720 17060-17061 NN denotes c
T8721 17062-17065 NN denotes Met
T8722 17061-17062 HYPH denotes -
T8723 17071-17073 TO denotes to
T8724 17074-17078 VB denotes form
T8725 17079-17091 VBN denotes muscularized
T8726 17109-17114 NNS denotes folds
T8727 17092-17108 JJ denotes pleuroperitoneal
T8728 17115-17116 -LRB- denotes (
T8729 17116-17120 NNS denotes PPFs
T8730 17120-17121 -RRB- denotes )
T8731 17121-17123 , denotes ,
T8732 17123-17126 CC denotes and
T8733 17127-17131 RB denotes thus
T8734 17132-17136 VBP denotes have
T8735 17137-17146 JJ denotes amuscular
T8736 17147-17157 NNS denotes diaphragms
T8737 17158-17159 -LRB- denotes [
T8738 17162-17164 CD denotes 25
T8739 17159-17161 CD denotes 24
T8740 17161-17162 , denotes ,
T8741 17164-17165 -RRB- denotes ]
T8742 17165-17166 . denotes .
T8743 17166-17307 sentence denotes Fog2 is expressed diffusely in the early amuscular diaphragm at E11.5 as well as in the later muscularized diaphragm (see Figure 3C and 3D).
T8744 17167-17171 NN denotes Fog2
T8745 17175-17184 VBN denotes expressed
T8746 17172-17174 VBZ denotes is
T8747 17185-17194 RB denotes diffusely
T8748 17195-17197 IN denotes in
T8749 17198-17201 DT denotes the
T8750 17218-17227 NN denotes diaphragm
T8751 17202-17207 JJ denotes early
T8752 17208-17217 JJ denotes amuscular
T8753 17228-17230 IN denotes at
T8754 17231-17236 NN denotes E11.5
T8755 17237-17239 RB denotes as
T8756 17245-17247 IN denotes as
T8757 17240-17244 RB denotes well
T8758 17248-17250 IN denotes in
T8759 17251-17254 DT denotes the
T8760 17274-17283 NN denotes diaphragm
T8761 17255-17260 JJ denotes later
T8762 17261-17273 VBN denotes muscularized
T8763 17284-17285 -LRB- denotes (
T8764 17285-17288 VB denotes see
T8765 17289-17295 NN denotes Figure
T8766 17296-17298 CD denotes 3C
T8767 17299-17302 CC denotes and
T8768 17303-17305 CD denotes 3D
T8769 17305-17306 -RRB- denotes )
T8770 17306-17307 . denotes .
T8771 17307-17482 sentence denotes Pax3 and MyoD, transcription factors required for appropriate migration and determination of myogenic precursors, were detected in the PPFs of Fog2 lil mice (data not shown).
T8772 17308-17312 NN denotes Pax3
T8773 17427-17435 VBN denotes detected
T8774 17313-17316 CC denotes and
T8775 17317-17321 NN denotes MyoD
T8776 17321-17323 , denotes ,
T8777 17323-17336 NN denotes transcription
T8778 17337-17344 NNS denotes factors
T8779 17345-17353 VBN denotes required
T8780 17354-17357 IN denotes for
T8781 17358-17369 JJ denotes appropriate
T8782 17370-17379 NN denotes migration
T8783 17380-17383 CC denotes and
T8784 17384-17397 NN denotes determination
T8785 17398-17400 IN denotes of
T8786 17401-17409 JJ denotes myogenic
T8787 17410-17420 NNS denotes precursors
T8788 17420-17422 , denotes ,
T8789 17422-17426 VBD denotes were
T8790 17436-17438 IN denotes in
T8791 17439-17442 DT denotes the
T8792 17443-17447 NNS denotes PPFs
T8793 17448-17450 IN denotes of
T8794 17451-17455 NN denotes Fog2
T8795 17460-17464 NNS denotes mice
T8796 17456-17459 NN denotes lil
T8797 17465-17466 -LRB- denotes (
T8798 17475-17480 VBN denotes shown
T8799 17466-17470 NNS denotes data
T8800 17471-17474 RB denotes not
T8801 17480-17481 -RRB- denotes )
T8802 17481-17482 . denotes .
T8803 17482-17678 sentence denotes However, in situ expression analysis demonstrated that the expression of HGF in the region where this structure meets the membranous diaphragm was markedly reduced in Fog2 mutant mice (Figure 6).
T8804 17483-17490 RB denotes However
T8805 17520-17532 VBD denotes demonstrated
T8806 17490-17492 , denotes ,
T8807 17492-17494 FW denotes in
T8808 17495-17499 FW denotes situ
T8809 17511-17519 NN denotes analysis
T8810 17500-17510 NN denotes expression
T8811 17533-17537 IN denotes that
T8812 17639-17646 VBN denotes reduced
T8813 17538-17541 DT denotes the
T8814 17542-17552 NN denotes expression
T8815 17553-17555 IN denotes of
T8816 17556-17559 NN denotes HGF
T8817 17560-17562 IN denotes in
T8818 17563-17566 DT denotes the
T8819 17567-17573 NN denotes region
T8820 17574-17579 WRB denotes where
T8821 17595-17600 VBZ denotes meets
T8823 17585-17594 NN denotes structure
T8824 17601-17604 DT denotes the
T8825 17616-17625 NN denotes diaphragm
T8826 17605-17615 JJ denotes membranous
T8827 17626-17629 VBD denotes was
T8828 17630-17638 RB denotes markedly
T8829 17647-17649 IN denotes in
T8830 17650-17654 NN denotes Fog2
T8831 17662-17666 NNS denotes mice
T8832 17655-17661 NN denotes mutant
T8833 17667-17668 -LRB- denotes (
T8834 17668-17674 NN denotes Figure
T8835 17675-17676 CD denotes 6
T8836 17676-17677 -RRB- denotes )
T8837 17677-17678 . denotes .
T8838 17678-17972 sentence denotes We hypothesize that Fog2 is required (either directly or indirectly) for the induction of HGF in the developing diaphragm, and dysregulation of HGF patterning along the path of muscle precursor cell migration between the PPF and the diaphragm accounts for the abnormal phenotype in these mice.
T8839 17679-17681 PRP denotes We
T8840 17682-17693 VBP denotes hypothesize
T8841 17694-17698 IN denotes that
T8842 17707-17715 VBN denotes required
T8843 17699-17703 NN denotes Fog2
T8844 17704-17706 VBZ denotes is
T8845 17716-17717 -LRB- denotes (
T8846 17717-17723 CC denotes either
T8847 17724-17732 RB denotes directly
T8848 17733-17735 CC denotes or
T8849 17736-17746 RB denotes indirectly
T8850 17746-17747 -RRB- denotes )
T8851 17748-17751 IN denotes for
T8852 17752-17755 DT denotes the
T8853 17756-17765 NN denotes induction
T8854 17766-17768 IN denotes of
T8855 17769-17772 NN denotes HGF
T8856 17773-17775 IN denotes in
T8857 17776-17779 DT denotes the
T8858 17791-17800 NN denotes diaphragm
T8859 17780-17790 VBG denotes developing
T8860 17800-17802 , denotes ,
T8861 17802-17805 CC denotes and
T8862 17806-17819 NN denotes dysregulation
T8863 17922-17930 VBZ denotes accounts
T8864 17820-17822 IN denotes of
T8865 17823-17826 NN denotes HGF
T8866 17827-17837 NN denotes patterning
T8867 17838-17843 IN denotes along
T8868 17844-17847 DT denotes the
T8869 17848-17852 NN denotes path
T8870 17853-17855 IN denotes of
T8871 17856-17862 NN denotes muscle
T8872 17873-17877 NN denotes cell
T8873 17863-17872 NN denotes precursor
T8874 17878-17887 NN denotes migration
T8875 17888-17895 IN denotes between
T8876 17896-17899 DT denotes the
T8877 17900-17903 NN denotes PPF
T8878 17904-17907 CC denotes and
T8879 17908-17911 DT denotes the
T8880 17912-17921 NN denotes diaphragm
T8881 17931-17934 IN denotes for
T8882 17935-17938 DT denotes the
T8883 17948-17957 NN denotes phenotype
T8884 17939-17947 JJ denotes abnormal
T8885 17958-17960 IN denotes in
T8886 17961-17966 DT denotes these
T8887 17967-17971 NNS denotes mice
T8888 17971-17972 . denotes .
T9907 18221-18225 NN denotes FOG2
T9908 18226-18234 NN denotes Mutation
T9909 18235-18237 IN denotes in
T9910 18238-18239 DT denotes a
T9911 18240-18247 NN denotes Patient
T9912 18248-18252 IN denotes with
T9913 18253-18262 NN denotes Diaphragm
T9914 18272-18285 NNS denotes Abnormalities
T9915 18263-18266 CC denotes and
T9916 18267-18271 NN denotes Lung
T9917 18285-18509 sentence denotes FOG2 sequence analysis was performed on autopsy tissue from 30 of 32 deceased children with an anatomic diagnosis of diaphragmatic defect evaluated at the Children's Hospital in Boston, Massachusetts, between 1993 and 2003.
T9918 18286-18290 NN denotes FOG2
T9919 18300-18308 NN denotes analysis
T9920 18291-18299 NN denotes sequence
T9921 18313-18322 VBN denotes performed
T9922 18309-18312 VBD denotes was
T9923 18323-18325 IN denotes on
T9924 18326-18333 NN denotes autopsy
T9925 18334-18340 NN denotes tissue
T9926 18341-18345 IN denotes from
T9927 18346-18348 CD denotes 30
T9928 18352-18354 CD denotes 32
T9929 18349-18351 IN denotes of
T9930 18364-18372 NNS denotes children
T9931 18355-18363 VBN denotes deceased
T9932 18373-18377 IN denotes with
T9933 18378-18380 DT denotes an
T9934 18390-18399 NN denotes diagnosis
T9935 18381-18389 JJ denotes anatomic
T9936 18400-18402 IN denotes of
T9937 18403-18416 JJ denotes diaphragmatic
T9938 18417-18423 NN denotes defect
T9939 18424-18433 VBN denotes evaluated
T9940 18434-18436 IN denotes at
T9941 18437-18440 DT denotes the
T9942 18452-18460 NNP denotes Hospital
T9943 18441-18449 NNPS denotes Children
T9944 18449-18451 POS denotes 's
T9945 18461-18463 IN denotes in
T9946 18464-18470 NNP denotes Boston
T9947 18470-18472 , denotes ,
T9948 18472-18485 NNP denotes Massachusetts
T9949 18485-18487 , denotes ,
T9950 18487-18494 IN denotes between
T9951 18495-18499 CD denotes 1993
T9952 18500-18503 CC denotes and
T9953 18504-18508 CD denotes 2003
T9954 18508-18509 . denotes .
T9955 18509-18576 sentence denotes Autopsy reports were reviewed to determine the specific diagnoses.
T9956 18510-18517 NN denotes Autopsy
T9957 18518-18525 NNS denotes reports
T9958 18531-18539 VBN denotes reviewed
T9959 18526-18530 VBD denotes were
T9960 18540-18542 TO denotes to
T9961 18543-18552 VB denotes determine
T9962 18553-18556 DT denotes the
T9963 18566-18575 NNS denotes diagnoses
T9964 18557-18565 JJ denotes specific
T9965 18575-18576 . denotes .
T9966 18576-18838 sentence denotes Of these 30 cases, 17 (57%) had Bochdalek CDH, two (7%) had diaphragmatic agenesis, seven (23%) had diaphragmatic eventration/muscularization defects (without Bochdalek CDH), and four (13%) had Bochdalek hernia of one hemidiaphragm and eventration of the other.
T9967 18577-18579 IN denotes Of
T9968 18605-18608 VBD denotes had
T9969 18580-18585 DT denotes these
T9970 18589-18594 NNS denotes cases
T9971 18586-18588 CD denotes 30
T9972 18594-18596 , denotes ,
T9973 18596-18598 CD denotes 17
T9974 18599-18600 -LRB- denotes (
T9975 18602-18603 NN denotes %
T9976 18600-18602 CD denotes 57
T9977 18603-18604 -RRB- denotes )
T9978 18609-18618 NNP denotes Bochdalek
T9979 18619-18622 NN denotes CDH
T9980 18622-18624 , denotes ,
T9981 18624-18627 CD denotes two
T9982 18633-18636 VBD denotes had
T9983 18628-18629 -LRB- denotes (
T9984 18630-18631 NN denotes %
T9985 18629-18630 CD denotes 7
T9986 18631-18632 -RRB- denotes )
T9987 18637-18650 JJ denotes diaphragmatic
T9988 18651-18659 NN denotes agenesis
T9989 18659-18661 , denotes ,
T9990 18661-18666 CD denotes seven
T9991 18673-18676 VBD denotes had
T9992 18667-18668 -LRB- denotes (
T9993 18670-18671 NN denotes %
T9994 18668-18670 CD denotes 23
T9995 18671-18672 -RRB- denotes )
T9996 18677-18690 JJ denotes diaphragmatic
T9997 18691-18702 NN denotes eventration
T9998 18702-18703 HYPH denotes /
T9999 18703-18718 NN denotes muscularization
T10000 18719-18726 NNS denotes defects
T10001 18727-18728 -LRB- denotes (
T10002 18728-18735 IN denotes without
T10003 18736-18745 NNP denotes Bochdalek
T10004 18746-18749 NN denotes CDH
T10005 18749-18750 -RRB- denotes )
T10006 18750-18752 , denotes ,
T10007 18752-18755 CC denotes and
T10008 18756-18760 CD denotes four
T10009 18767-18770 VBD denotes had
T10010 18761-18762 -LRB- denotes (
T10011 18764-18765 NN denotes %
T10012 18762-18764 CD denotes 13
T10013 18765-18766 -RRB- denotes )
T10014 18771-18780 NNP denotes Bochdalek
T10015 18781-18787 NN denotes hernia
T10016 18788-18790 IN denotes of
T10017 18791-18794 CD denotes one
T10018 18795-18808 NN denotes hemidiaphragm
T10019 18809-18812 CC denotes and
T10020 18813-18824 NN denotes eventration
T10021 18825-18827 IN denotes of
T10022 18828-18831 DT denotes the
T10023 18832-18837 NN denotes other
T10024 18837-18838 . denotes .
T10025 18838-18934 sentence denotes Pulmonary hypoplasia was assessed using lung/body weight ratio and radial alveolar counts [26].
T10026 18839-18848 JJ denotes Pulmonary
T10027 18849-18859 NN denotes hypoplasia
T10028 18864-18872 VBN denotes assessed
T10029 18860-18863 VBD denotes was
T10030 18873-18878 VBG denotes using
T10031 18879-18883 NN denotes lung
T10032 18884-18888 NN denotes body
T10033 18883-18884 HYPH denotes /
T10034 18896-18901 NN denotes ratio
T10035 18889-18895 NN denotes weight
T10036 18902-18905 CC denotes and
T10037 18906-18912 JJ denotes radial
T10038 18922-18928 NNS denotes counts
T10039 18913-18921 JJ denotes alveolar
T10040 18929-18930 -LRB- denotes [
T10041 18930-18932 CD denotes 26
T10042 18932-18933 -RRB- denotes ]
T10043 18933-18934 . denotes .
T10044 18934-19072 sentence denotes The material available for review included written reports and histologic slides in all cases and gross kodachromes in a subset of cases.
T10045 18935-18938 DT denotes The
T10046 18939-18947 NN denotes material
T10047 18969-18977 VBN denotes included
T10048 18948-18957 JJ denotes available
T10049 18958-18961 IN denotes for
T10050 18962-18968 NN denotes review
T10051 18978-18985 VBN denotes written
T10052 18986-18993 NNS denotes reports
T10053 18994-18997 CC denotes and
T10054 18998-19008 JJ denotes histologic
T10055 19009-19015 NNS denotes slides
T10056 19016-19018 IN denotes in
T10057 19019-19022 DT denotes all
T10058 19023-19028 NNS denotes cases
T10059 19029-19032 CC denotes and
T10060 19033-19038 JJ denotes gross
T10061 19039-19050 NNS denotes kodachromes
T10062 19051-19053 IN denotes in
T10063 19054-19055 DT denotes a
T10064 19056-19062 NN denotes subset
T10065 19063-19065 IN denotes of
T10066 19066-19071 NNS denotes cases
T10067 19071-19072 . denotes .
T10068 19072-19133 sentence denotes One child carried a highly significant FOG2 sequence change.
T10069 19073-19076 CD denotes One
T10070 19077-19082 NN denotes child
T10071 19083-19090 VBD denotes carried
T10072 19091-19092 DT denotes a
T10073 19126-19132 NN denotes change
T10074 19093-19099 RB denotes highly
T10075 19100-19111 JJ denotes significant
T10076 19112-19116 NN denotes FOG2
T10077 19117-19125 NN denotes sequence
T10078 19132-19133 . denotes .
T10079 19133-19266 sentence denotes The patient was a full-term 3,500-g baby girl who developed severe respiratory failure at birth and died after 5 h of resuscitation.
T10080 19134-19137 DT denotes The
T10081 19138-19145 NN denotes patient
T10082 19146-19149 VBD denotes was
T10083 19150-19151 DT denotes a
T10084 19175-19179 NN denotes girl
T10085 19152-19156 JJ denotes full
T10086 19157-19161 NN denotes term
T10087 19156-19157 HYPH denotes -
T10088 19162-19167 CD denotes 3,500
T10089 19168-19169 NN denotes g
T10090 19167-19168 HYPH denotes -
T10091 19170-19174 NN denotes baby
T10092 19180-19183 WP denotes who
T10093 19184-19193 VBD denotes developed
T10094 19194-19200 JJ denotes severe
T10095 19213-19220 NN denotes failure
T10096 19201-19212 JJ denotes respiratory
T10097 19221-19223 IN denotes at
T10098 19224-19229 NN denotes birth
T10099 19230-19233 CC denotes and
T10100 19234-19238 VBD denotes died
T10101 19239-19244 IN denotes after
T10102 19245-19246 CD denotes 5
T10103 19247-19248 NN denotes h
T10104 19249-19251 IN denotes of
T10105 19252-19265 NN denotes resuscitation
T10106 19265-19266 . denotes .
T10107 19266-19351 sentence denotes Antemortem radiographs showed opacified lung fields and possible bowel in the chest.
T10108 19267-19277 NN denotes Antemortem
T10109 19278-19289 NNS denotes radiographs
T10110 19290-19296 VBD denotes showed
T10111 19297-19306 VBN denotes opacified
T10112 19312-19318 NNS denotes fields
T10113 19307-19311 NN denotes lung
T10114 19319-19322 CC denotes and
T10115 19323-19331 JJ denotes possible
T10116 19332-19337 NN denotes bowel
T10117 19338-19340 IN denotes in
T10118 19341-19344 DT denotes the
T10119 19345-19350 NN denotes chest
T10120 19350-19351 . denotes .
T10121 19351-19393 sentence denotes The patient's clinical diagnosis was CDH.
T10122 19352-19355 DT denotes The
T10123 19356-19363 NN denotes patient
T10124 19375-19384 NN denotes diagnosis
T10125 19363-19365 POS denotes 's
T10126 19366-19374 JJ denotes clinical
T10127 19385-19388 VBD denotes was
T10128 19389-19392 NN denotes CDH
T10129 19392-19393 . denotes .
T10130 19393-19592 sentence denotes Review of autopsy material revealed severe bilateral pulmonary hypoplasia (combined lung weight, 11.1 g; expected for body length/weight, 46.8 ± 26.2 g; [27]), most markedly involving the left lung.
T10131 19394-19400 NN denotes Review
T10132 19421-19429 VBD denotes revealed
T10133 19401-19403 IN denotes of
T10134 19404-19411 NN denotes autopsy
T10135 19412-19420 NN denotes material
T10136 19430-19436 JJ denotes severe
T10137 19457-19467 NN denotes hypoplasia
T10138 19437-19446 JJ denotes bilateral
T10139 19447-19456 JJ denotes pulmonary
T10140 19468-19469 -LRB- denotes (
T10141 19548-19550 CD denotes 27
T10142 19469-19477 VBN denotes combined
T10143 19483-19489 NN denotes weight
T10144 19478-19482 NN denotes lung
T10145 19496-19497 NN denotes g
T10146 19489-19491 , denotes ,
T10147 19491-19495 CD denotes 11.1
T10148 19497-19498 : denotes ;
T10149 19499-19507 VBN denotes expected
T10150 19508-19511 IN denotes for
T10151 19512-19516 NN denotes body
T10152 19524-19530 NN denotes weight
T10153 19517-19523 NN denotes length
T10154 19523-19524 HYPH denotes /
T10155 19530-19532 , denotes ,
T10156 19532-19536 CD denotes 46.8
T10157 19539-19543 CD denotes 26.2
T10158 19537-19538 SYM denotes ±
T10159 19544-19545 NN denotes g
T10160 19545-19546 : denotes ;
T10161 19547-19548 -LRB- denotes [
T10162 19550-19551 -RRB- denotes ]
T10163 19551-19552 -RRB- denotes )
T10164 19552-19554 , denotes ,
T10165 19554-19558 RBS denotes most
T10166 19559-19567 RB denotes markedly
T10167 19568-19577 VBG denotes involving
T10168 19578-19581 DT denotes the
T10169 19587-19591 NN denotes lung
T10170 19582-19586 JJ denotes left
T10171 19591-19592 . denotes .
T10172 19592-19655 sentence denotes The lung/body weight ratio was 0.0037 (expected > 0.010) [28].
T10173 19593-19596 DT denotes The
T10174 19614-19619 NN denotes ratio
T10175 19597-19601 NN denotes lung
T10176 19601-19602 SYM denotes /
T10177 19602-19606 NN denotes body
T10178 19607-19613 NN denotes weight
T10179 19620-19623 VBD denotes was
T10180 19624-19630 CD denotes 0.0037
T10181 19631-19632 -LRB- denotes (
T10182 19643-19648 CD denotes 0.010
T10183 19632-19640 VBN denotes expected
T10184 19641-19642 SYM denotes >
T10185 19648-19649 -RRB- denotes )
T10186 19650-19651 -LRB- denotes [
T10187 19651-19653 CD denotes 28
T10188 19653-19654 -RRB- denotes ]
T10189 19654-19655 . denotes .
T10190 19655-19768 sentence denotes There were a reduced number of bronchial generations, and the radial alveolar count was 2–3 (expected = 5) [29].
T10191 19656-19661 EX denotes There
T10192 19662-19666 VBD denotes were
T10193 19667-19668 DT denotes a
T10194 19677-19683 NN denotes number
T10195 19669-19676 VBN denotes reduced
T10196 19684-19686 IN denotes of
T10197 19687-19696 JJ denotes bronchial
T10198 19697-19708 NNS denotes generations
T10199 19708-19710 , denotes ,
T10200 19710-19713 CC denotes and
T10201 19714-19717 DT denotes the
T10202 19734-19739 NN denotes count
T10203 19718-19724 JJ denotes radial
T10204 19725-19733 JJ denotes alveolar
T10205 19740-19743 VBD denotes was
T10206 19744-19745 CD denotes 2
T10207 19746-19747 CD denotes 3
T10208 19745-19746 SYM denotes –
T10209 19748-19749 -LRB- denotes (
T10210 19760-19761 CD denotes 5
T10211 19749-19757 VBN denotes expected
T10212 19758-19759 SYM denotes =
T10213 19761-19762 -RRB- denotes )
T10214 19763-19764 -LRB- denotes [
T10215 19764-19766 CD denotes 29
T10216 19766-19767 -RRB- denotes ]
T10217 19767-19768 . denotes .
T10218 19768-19817 sentence denotes There were incomplete lung fissures bilaterally.
T10219 19769-19774 EX denotes There
T10220 19775-19779 VBD denotes were
T10221 19780-19790 JJ denotes incomplete
T10222 19796-19804 NNS denotes fissures
T10223 19791-19795 NN denotes lung
T10224 19805-19816 RB denotes bilaterally
T10225 19816-19817 . denotes .
T10226 19817-19890 sentence denotes A deep posterior diaphragmatic eventration was present on the left side.
T10227 19818-19819 DT denotes A
T10228 19849-19860 NN denotes eventration
T10229 19820-19824 JJ denotes deep
T10230 19825-19834 JJ denotes posterior
T10231 19835-19848 JJ denotes diaphragmatic
T10232 19861-19864 VBD denotes was
T10233 19865-19872 JJ denotes present
T10234 19873-19875 IN denotes on
T10235 19876-19879 DT denotes the
T10236 19885-19889 NN denotes side
T10237 19880-19884 JJ denotes left
T10238 19889-19890 . denotes .
T10239 19890-20056 sentence denotes Additionally, two muscularized ligamentous bands resembling diaphragmatic remnants encircled the left lobe of the liver, creating an abnormal fissured liver contour.
T10240 19891-19903 RB denotes Additionally
T10241 19974-19983 VBD denotes encircled
T10242 19903-19905 , denotes ,
T10243 19905-19908 CD denotes two
T10244 19934-19939 NNS denotes bands
T10245 19909-19921 VBN denotes muscularized
T10246 19922-19933 JJ denotes ligamentous
T10247 19940-19950 VBG denotes resembling
T10248 19951-19964 JJ denotes diaphragmatic
T10249 19965-19973 NNS denotes remnants
T10250 19984-19987 DT denotes the
T10251 19993-19997 NN denotes lobe
T10252 19988-19992 JJ denotes left
T10253 19998-20000 IN denotes of
T10254 20001-20004 DT denotes the
T10255 20005-20010 NN denotes liver
T10256 20010-20012 , denotes ,
T10257 20012-20020 VBG denotes creating
T10258 20021-20023 DT denotes an
T10259 20048-20055 NN denotes contour
T10260 20024-20032 JJ denotes abnormal
T10261 20033-20041 VBN denotes fissured
T10262 20042-20047 NN denotes liver
T10263 20055-20056 . denotes .
T10264 20056-20156 sentence denotes Away from the eventration, the diaphragm appeared well muscularized, measuring 0.3 cm in thickness.
T10265 20057-20061 RB denotes Away
T10266 20098-20106 VBD denotes appeared
T10267 20062-20066 IN denotes from
T10268 20067-20070 DT denotes the
T10269 20071-20082 NN denotes eventration
T10270 20082-20084 , denotes ,
T10271 20084-20087 DT denotes the
T10272 20088-20097 NN denotes diaphragm
T10273 20107-20111 RB denotes well
T10274 20112-20124 VBN denotes muscularized
T10275 20124-20126 , denotes ,
T10276 20126-20135 VBG denotes measuring
T10277 20136-20139 CD denotes 0.3
T10278 20140-20142 NN denotes cm
T10279 20143-20145 IN denotes in
T10280 20146-20155 NN denotes thickness
T10281 20155-20156 . denotes .
T10282 20156-20289 sentence denotes A complete autopsy revealed no other malformations; the heart was determined to be grossly normal and was donated for valve harvest.
T10283 20157-20158 DT denotes A
T10284 20168-20175 NN denotes autopsy
T10285 20159-20167 JJ denotes complete
T10286 20176-20184 VBD denotes revealed
T10287 20223-20233 VBN denotes determined
T10288 20185-20187 DT denotes no
T10289 20194-20207 NNS denotes malformations
T10290 20188-20193 JJ denotes other
T10291 20207-20208 : denotes ;
T10292 20209-20212 DT denotes the
T10293 20213-20218 NN denotes heart
T10294 20219-20222 VBD denotes was
T10295 20234-20236 TO denotes to
T10296 20237-20239 VB denotes be
T10297 20240-20247 RB denotes grossly
T10298 20248-20254 JJ denotes normal
T10299 20255-20258 CC denotes and
T10300 20259-20262 VBD denotes was
T10301 20263-20270 VBN denotes donated
T10302 20271-20274 IN denotes for
T10303 20275-20280 NN denotes valve
T10304 20281-20288 NN denotes harvest
T10305 20288-20289 . denotes .
T10306 20289-20433 sentence denotes Sequence analysis revealed a cytosine to thymine heterozygous change in exon 4 that changes the 112th amino acid from arginine to a stop codon.
T10307 20290-20298 NN denotes Sequence
T10308 20299-20307 NN denotes analysis
T10309 20308-20316 VBD denotes revealed
T10310 20317-20318 DT denotes a
T10311 20352-20358 NN denotes change
T10312 20319-20327 NN denotes cytosine
T10313 20328-20330 IN denotes to
T10314 20331-20338 NN denotes thymine
T10315 20339-20351 JJ denotes heterozygous
T10316 20359-20361 IN denotes in
T10317 20362-20366 NN denotes exon
T10318 20367-20368 CD denotes 4
T10319 20369-20373 WDT denotes that
T10320 20374-20381 VBZ denotes changes
T10321 20382-20385 DT denotes the
T10322 20398-20402 NN denotes acid
T10323 20386-20391 JJ denotes 112th
T10324 20392-20397 NN denotes amino
T10325 20403-20407 IN denotes from
T10326 20408-20416 NN denotes arginine
T10327 20417-20419 IN denotes to
T10328 20420-20421 DT denotes a
T10329 20427-20432 NN denotes codon
T10330 20422-20426 NN denotes stop
T10331 20432-20433 . denotes .
T10332 20433-20539 sentence denotes This mutation produces a severely truncated peptide that does not contain zinc finger domains (Figure 7).
T10333 20434-20438 DT denotes This
T10334 20439-20447 NN denotes mutation
T10335 20448-20456 VBZ denotes produces
T10336 20457-20458 DT denotes a
T10337 20478-20485 NN denotes peptide
T10338 20459-20467 RB denotes severely
T10339 20468-20477 VBN denotes truncated
T10340 20486-20490 WDT denotes that
T10341 20500-20507 VB denotes contain
T10342 20491-20495 VBZ denotes does
T10343 20496-20499 RB denotes not
T10344 20508-20512 NN denotes zinc
T10345 20513-20519 NN denotes finger
T10346 20520-20527 NNS denotes domains
T10347 20528-20529 -LRB- denotes (
T10348 20529-20535 NN denotes Figure
T10349 20536-20537 CD denotes 7
T10350 20537-20538 -RRB- denotes )
T10351 20538-20539 . denotes .
T10352 20539-20619 sentence denotes This base change was not present in the analysis of DNA from 400 normal adults.
T10353 20540-20544 DT denotes This
T10354 20550-20556 NN denotes change
T10355 20545-20549 NN denotes base
T10356 20557-20560 VBD denotes was
T10357 20561-20564 RB denotes not
T10358 20565-20572 JJ denotes present
T10359 20573-20575 IN denotes in
T10360 20576-20579 DT denotes the
T10361 20580-20588 NN denotes analysis
T10362 20589-20591 IN denotes of
T10363 20592-20595 NN denotes DNA
T10364 20596-20600 IN denotes from
T10365 20601-20604 CD denotes 400
T10366 20612-20618 NNS denotes adults
T10367 20605-20611 JJ denotes normal
T10368 20618-20619 . denotes .
T10369 20619-20732 sentence denotes To assess the likelihood that the mutation was causal for the developmental phenotype, we examined both parents.
T10370 20620-20622 TO denotes To
T10371 20623-20629 VB denotes assess
T10372 20710-20718 VBD denotes examined
T10373 20630-20633 DT denotes the
T10374 20634-20644 NN denotes likelihood
T10375 20645-20649 IN denotes that
T10376 20663-20666 VBD denotes was
T10377 20650-20653 DT denotes the
T10378 20654-20662 NN denotes mutation
T10379 20667-20673 JJ denotes causal
T10380 20674-20677 IN denotes for
T10381 20678-20681 DT denotes the
T10382 20696-20705 NN denotes phenotype
T10383 20682-20695 JJ denotes developmental
T10384 20705-20707 , denotes ,
T10385 20707-20709 PRP denotes we
T10386 20719-20723 DT denotes both
T10387 20724-20731 NNS denotes parents
T10388 20731-20732 . denotes .
T10389 20732-20903 sentence denotes Paternity was confirmed, and sequence analysis revealed that the neither parent carried this mutation, proving that the patient had a de novo mutation in FOG2 (Figure 7).
T10390 20733-20742 NN denotes Paternity
T10391 20747-20756 VBN denotes confirmed
T10392 20743-20746 VBD denotes was
T10393 20756-20758 , denotes ,
T10394 20758-20761 CC denotes and
T10395 20762-20770 NN denotes sequence
T10396 20771-20779 NN denotes analysis
T10397 20780-20788 VBD denotes revealed
T10398 20789-20793 IN denotes that
T10399 20813-20820 VBD denotes carried
T10400 20794-20797 DT denotes the
T10401 20806-20812 NN denotes parent
T10402 20798-20805 CC denotes neither
T10403 20821-20825 DT denotes this
T10404 20826-20834 NN denotes mutation
T10405 20834-20836 , denotes ,
T10406 20836-20843 VBG denotes proving
T10407 20844-20848 IN denotes that
T10408 20861-20864 VBD denotes had
T10409 20849-20852 DT denotes the
T10410 20853-20860 NN denotes patient
T10411 20865-20866 DT denotes a
T10412 20875-20883 NN denotes mutation
T10413 20867-20869 FW denotes de
T10414 20870-20874 FW denotes novo
T10415 20884-20886 IN denotes in
T10416 20887-20891 NN denotes FOG2
T10417 20892-20893 -LRB- denotes (
T10418 20893-20899 NN denotes Figure
T10419 20900-20901 CD denotes 7
T10420 20901-20902 -RRB- denotes )
T10421 20902-20903 . denotes .
T13037 21278-21288 JJ denotes Congenital
T13038 21303-21310 NNS denotes defects
T13039 21289-21302 JJ denotes diaphragmatic
T13040 21311-21314 VBP denotes are
T13041 21315-21316 DT denotes a
T13042 21331-21336 NN denotes group
T13043 21317-21330 JJ denotes heterogeneous
T13044 21337-21339 IN denotes of
T13045 21340-21349 NNS denotes disorders
T13046 21350-21352 IN denotes of
T13047 21353-21360 JJ denotes unknown
T13048 21361-21369 NN denotes etiology
T13049 21369-21370 . denotes .
T13050 21370-21540 sentence denotes The defects that present in the pre- or perinatal period include Bochdalek hernia, diaphragmatic aplasia, and various degrees of muscularization defects or eventrations.
T13051 21371-21374 DT denotes The
T13052 21375-21382 NNS denotes defects
T13053 21428-21435 VBP denotes include
T13054 21383-21387 WDT denotes that
T13055 21388-21395 VBP denotes present
T13056 21396-21398 IN denotes in
T13057 21399-21402 DT denotes the
T13058 21421-21427 NN denotes period
T13059 21403-21406 AFX denotes pre
T13060 21411-21420 JJ denotes perinatal
T13061 21406-21407 HYPH denotes -
T13062 21408-21410 CC denotes or
T13063 21436-21445 NNP denotes Bochdalek
T13064 21446-21452 NN denotes hernia
T13065 21452-21454 , denotes ,
T13066 21454-21467 JJ denotes diaphragmatic
T13067 21468-21475 NN denotes aplasia
T13068 21475-21477 , denotes ,
T13069 21477-21480 CC denotes and
T13070 21481-21488 JJ denotes various
T13071 21489-21496 NNS denotes degrees
T13072 21497-21499 IN denotes of
T13073 21500-21515 NN denotes muscularization
T13074 21516-21523 NNS denotes defects
T13075 21524-21526 CC denotes or
T13076 21527-21539 NNS denotes eventrations
T13077 21539-21540 . denotes .
T13078 21540-21702 sentence denotes Different types of defects occur in the same patients or in siblings, suggesting these represent variable expression of the same underlying pathogenesis [30,31].
T13079 21541-21550 JJ denotes Different
T13080 21551-21556 NNS denotes types
T13081 21568-21573 VBP denotes occur
T13082 21557-21559 IN denotes of
T13083 21560-21567 NNS denotes defects
T13084 21574-21576 IN denotes in
T13085 21577-21580 DT denotes the
T13086 21586-21594 NNS denotes patients
T13087 21581-21585 JJ denotes same
T13088 21595-21597 CC denotes or
T13089 21598-21600 IN denotes in
T13090 21601-21609 NNS denotes siblings
T13091 21609-21611 , denotes ,
T13092 21611-21621 VBG denotes suggesting
T13093 21622-21627 DT denotes these
T13094 21628-21637 VBP denotes represent
T13095 21638-21646 JJ denotes variable
T13096 21647-21657 NN denotes expression
T13097 21658-21660 IN denotes of
T13098 21661-21664 DT denotes the
T13099 21681-21693 NN denotes pathogenesis
T13100 21665-21669 JJ denotes same
T13101 21670-21680 VBG denotes underlying
T13102 21694-21695 -LRB- denotes [
T13103 21698-21700 CD denotes 31
T13104 21695-21697 CD denotes 30
T13105 21697-21698 , denotes ,
T13106 21700-21701 -RRB- denotes ]
T13107 21701-21702 . denotes .
T13108 21702-21935 sentence denotes Clinical differentiation between these defects may be very difficult, as the residual membranous diaphragm of a muscularization defect is thin and may not be easily visible on prenatal ultrasound or postnatal chest radiographs [32].
T13109 21703-21711 JJ denotes Clinical
T13110 21712-21727 NN denotes differentiation
T13111 21754-21756 VB denotes be
T13112 21728-21735 IN denotes between
T13113 21736-21741 DT denotes these
T13114 21742-21749 NNS denotes defects
T13115 21750-21753 MD denotes may
T13116 21757-21761 RB denotes very
T13117 21762-21771 JJ denotes difficult
T13118 21771-21773 , denotes ,
T13119 21773-21775 IN denotes as
T13120 21838-21840 VBZ denotes is
T13121 21776-21779 DT denotes the
T13122 21800-21809 NN denotes diaphragm
T13123 21780-21788 JJ denotes residual
T13124 21789-21799 JJ denotes membranous
T13125 21810-21812 IN denotes of
T13126 21813-21814 DT denotes a
T13127 21831-21837 NN denotes defect
T13128 21815-21830 NN denotes muscularization
T13129 21841-21845 JJ denotes thin
T13130 21846-21849 CC denotes and
T13131 21850-21853 MD denotes may
T13132 21858-21860 VB denotes be
T13133 21854-21857 RB denotes not
T13134 21861-21867 RB denotes easily
T13135 21868-21875 JJ denotes visible
T13136 21876-21878 IN denotes on
T13137 21879-21887 JJ denotes prenatal
T13138 21888-21898 JJ denotes ultrasound
T13139 21899-21901 CC denotes or
T13140 21902-21911 JJ denotes postnatal
T13141 21918-21929 NNS denotes radiographs
T13142 21912-21917 NN denotes chest
T13143 21930-21931 -LRB- denotes [
T13144 21931-21933 CD denotes 32
T13145 21933-21934 -RRB- denotes ]
T13146 21934-21935 . denotes .
T13147 21935-22194 sentence denotes Although diaphragmatic muscularization defects were historically considered to be predictive of a good outcome, there have been inadequate population-based studies that include fetal or neonatal cases and autopsy diagnoses to make this conclusion definitive.
T13148 21936-21944 IN denotes Although
T13149 22001-22011 VBN denotes considered
T13150 21945-21958 JJ denotes diaphragmatic
T13151 21975-21982 NNS denotes defects
T13152 21959-21974 NN denotes muscularization
T13153 21983-21987 VBD denotes were
T13154 21988-22000 RB denotes historically
T13155 22059-22063 VBN denotes been
T13156 22012-22014 TO denotes to
T13157 22015-22017 VB denotes be
T13158 22018-22028 JJ denotes predictive
T13159 22029-22031 IN denotes of
T13160 22032-22033 DT denotes a
T13161 22039-22046 NN denotes outcome
T13162 22034-22038 JJ denotes good
T13163 22046-22048 , denotes ,
T13164 22048-22053 EX denotes there
T13165 22054-22058 VBP denotes have
T13166 22064-22074 JJ denotes inadequate
T13167 22092-22099 NNS denotes studies
T13168 22075-22085 NN denotes population
T13169 22086-22091 VBN denotes based
T13170 22085-22086 HYPH denotes -
T13171 22100-22104 WDT denotes that
T13172 22105-22112 VBP denotes include
T13173 22113-22118 JJ denotes fetal
T13174 22131-22136 NNS denotes cases
T13175 22119-22121 CC denotes or
T13176 22122-22130 JJ denotes neonatal
T13177 22137-22140 CC denotes and
T13178 22141-22148 NN denotes autopsy
T13179 22149-22158 NNS denotes diagnoses
T13180 22159-22161 TO denotes to
T13181 22162-22166 VB denotes make
T13182 22167-22171 DT denotes this
T13183 22172-22182 NN denotes conclusion
T13184 22183-22193 JJ denotes definitive
T13185 22193-22194 . denotes .
T13186 22194-22445 sentence denotes In fact, the series of patients we report here and the published literature indicate that an eventration defect may be associated with displacement of abdominal contents and also with severe pulmonary hypoplasia and respiratory insufficiency [33,34].
T13187 22195-22197 IN denotes In
T13188 22271-22279 VBP denotes indicate
T13189 22198-22202 NN denotes fact
T13190 22202-22204 , denotes ,
T13191 22204-22207 DT denotes the
T13192 22208-22214 NN denotes series
T13193 22215-22217 IN denotes of
T13194 22218-22226 NNS denotes patients
T13195 22227-22229 PRP denotes we
T13196 22230-22236 VBP denotes report
T13197 22237-22241 RB denotes here
T13198 22242-22245 CC denotes and
T13199 22246-22249 DT denotes the
T13200 22260-22270 NN denotes literature
T13201 22250-22259 VBN denotes published
T13202 22280-22284 IN denotes that
T13203 22314-22324 VBN denotes associated
T13204 22285-22287 DT denotes an
T13205 22300-22306 NN denotes defect
T13206 22288-22299 NN denotes eventration
T13207 22307-22310 MD denotes may
T13208 22311-22313 VB denotes be
T13209 22325-22329 IN denotes with
T13210 22330-22342 NN denotes displacement
T13211 22343-22345 IN denotes of
T13212 22346-22355 JJ denotes abdominal
T13213 22356-22364 NNS denotes contents
T13214 22365-22368 CC denotes and
T13215 22369-22373 RB denotes also
T13216 22374-22378 IN denotes with
T13217 22379-22385 JJ denotes severe
T13218 22396-22406 NN denotes hypoplasia
T13219 22386-22395 JJ denotes pulmonary
T13220 22407-22410 CC denotes and
T13221 22411-22422 JJ denotes respiratory
T13222 22423-22436 NN denotes insufficiency
T13223 22437-22438 -LRB- denotes [
T13224 22441-22443 CD denotes 34
T13225 22438-22440 CD denotes 33
T13226 22440-22441 , denotes ,
T13227 22443-22444 -RRB- denotes ]
T13228 22444-22445 . denotes .
T13229 22445-22559 sentence denotes Numerous chromosome abnormalities have been found in association with congenital diaphragm abnormalities [12,35].
T13230 22446-22454 JJ denotes Numerous
T13231 22466-22479 NNS denotes abnormalities
T13232 22455-22465 NN denotes chromosome
T13233 22490-22495 VBN denotes found
T13234 22480-22484 VBP denotes have
T13235 22485-22489 VBN denotes been
T13236 22496-22498 IN denotes in
T13237 22499-22510 NN denotes association
T13238 22511-22515 IN denotes with
T13239 22516-22526 JJ denotes congenital
T13240 22537-22550 NNS denotes abnormalities
T13241 22527-22536 NN denotes diaphragm
T13242 22551-22552 -LRB- denotes [
T13243 22555-22557 CD denotes 35
T13244 22552-22554 CD denotes 12
T13245 22554-22555 , denotes ,
T13246 22557-22558 -RRB- denotes ]
T13247 22558-22559 . denotes .
T13248 22559-22715 sentence denotes Human FOG2 maps to Chromosome 8q23.1, and, importantly, several patients with diaphragm defects and rearrangements involving this locus have been reported.
T13249 22560-22565 JJ denotes Human
T13250 22566-22570 NN denotes FOG2
T13251 22571-22575 VBZ denotes maps
T13252 22576-22578 IN denotes to
T13253 22579-22589 NN denotes Chromosome
T13254 22590-22596 CD denotes 8q23.1
T13255 22596-22598 , denotes ,
T13256 22598-22601 CC denotes and
T13257 22601-22603 , denotes ,
T13258 22603-22614 RB denotes importantly
T13259 22706-22714 VBN denotes reported
T13260 22614-22616 , denotes ,
T13261 22616-22623 JJ denotes several
T13262 22624-22632 NNS denotes patients
T13263 22633-22637 IN denotes with
T13264 22638-22647 NN denotes diaphragm
T13265 22648-22655 NNS denotes defects
T13266 22656-22659 CC denotes and
T13267 22660-22674 NNS denotes rearrangements
T13268 22675-22684 VBG denotes involving
T13269 22685-22689 DT denotes this
T13270 22690-22695 NN denotes locus
T13271 22696-22700 VBP denotes have
T13272 22701-22705 VBN denotes been
T13273 22714-22715 . denotes .
T13274 22715-22848 sentence denotes Specifically, there are three unrelated CDH patients with cytogenetically balanced translocations at or near the FOG2 locus [36,37].
T13275 22716-22728 RB denotes Specifically
T13276 22736-22739 VBP denotes are
T13277 22728-22730 , denotes ,
T13278 22730-22735 EX denotes there
T13279 22740-22745 CD denotes three
T13280 22760-22768 NNS denotes patients
T13281 22746-22755 JJ denotes unrelated
T13282 22756-22759 NN denotes CDH
T13283 22769-22773 IN denotes with
T13284 22774-22789 RB denotes cytogenetically
T13285 22790-22798 VBN denotes balanced
T13286 22799-22813 NNS denotes translocations
T13287 22814-22816 IN denotes at
T13288 22817-22819 CC denotes or
T13289 22820-22824 IN denotes near
T13290 22825-22828 DT denotes the
T13291 22834-22839 NN denotes locus
T13292 22829-22833 NN denotes FOG2
T13293 22840-22841 -LRB- denotes [
T13294 22844-22846 CD denotes 37
T13295 22841-22843 CD denotes 36
T13296 22843-22844 , denotes ,
T13297 22846-22847 -RRB- denotes ]
T13298 22847-22848 . denotes .
T13299 22848-22997 sentence denotes Additionally, two patients with deletions apparently encompassing the FOG2 locus have died from multiple congenital anomalies including CDH [38–40].
T13300 22849-22861 RB denotes Additionally
T13301 22935-22939 VBN denotes died
T13302 22861-22863 , denotes ,
T13303 22863-22866 CD denotes two
T13304 22867-22875 NNS denotes patients
T13305 22876-22880 IN denotes with
T13306 22881-22890 NNS denotes deletions
T13307 22891-22901 RB denotes apparently
T13308 22902-22914 VBG denotes encompassing
T13309 22915-22918 DT denotes the
T13310 22924-22929 NN denotes locus
T13311 22919-22923 NN denotes FOG2
T13312 22930-22934 VBP denotes have
T13313 22940-22944 IN denotes from
T13314 22945-22953 JJ denotes multiple
T13315 22965-22974 NNS denotes anomalies
T13316 22954-22964 JJ denotes congenital
T13317 22975-22984 VBG denotes including
T13318 22985-22988 NN denotes CDH
T13319 22989-22990 -LRB- denotes [
T13320 22990-22992 CD denotes 38
T13321 22992-22993 SYM denotes –
T13322 22993-22995 CD denotes 40
T13323 22995-22996 -RRB- denotes ]
T13324 22996-22997 . denotes .
T13325 22997-23161 sentence denotes Inactivation of this gene due to chromosomal rearrangement or deletion would result in a heterozygous null mutation similar to that found in the patient we report.
T13326 22998-23010 NN denotes Inactivation
T13327 23075-23081 VB denotes result
T13328 23011-23013 IN denotes of
T13329 23014-23018 DT denotes this
T13330 23019-23023 NN denotes gene
T13331 23024-23027 IN denotes due
T13332 23028-23030 IN denotes to
T13333 23031-23042 JJ denotes chromosomal
T13334 23043-23056 NN denotes rearrangement
T13335 23057-23059 CC denotes or
T13336 23060-23068 NN denotes deletion
T13337 23069-23074 MD denotes would
T13338 23082-23084 IN denotes in
T13339 23085-23086 DT denotes a
T13340 23105-23113 NN denotes mutation
T13341 23087-23099 JJ denotes heterozygous
T13342 23100-23104 JJ denotes null
T13343 23114-23121 JJ denotes similar
T13344 23122-23124 IN denotes to
T13345 23125-23129 DT denotes that
T13346 23130-23135 VBN denotes found
T13347 23136-23138 IN denotes in
T13348 23139-23142 DT denotes the
T13349 23143-23150 NN denotes patient
T13350 23151-23153 PRP denotes we
T13351 23154-23160 VBP denotes report
T13352 23160-23161 . denotes .
T13353 23161-23434 sentence denotes Because the FOG2 mutation we report is de novo and the phenotypes of the pulmonary and diaphragmatic defects are similar between mouse and human, we suggest that this mutation in FOG2 is the first reported cause of a human developmental diaphragmatic and pulmonary defect.
T13354 23162-23169 IN denotes Because
T13355 23198-23200 VBZ denotes is
T13356 23170-23173 DT denotes the
T13357 23179-23187 NN denotes mutation
T13358 23174-23178 NN denotes FOG2
T13359 23188-23190 PRP denotes we
T13360 23191-23197 VBP denotes report
T13361 23311-23318 VBP denotes suggest
T13362 23201-23203 FW denotes de
T13363 23204-23208 FW denotes novo
T13364 23209-23212 CC denotes and
T13365 23213-23216 DT denotes the
T13366 23217-23227 NNS denotes phenotypes
T13367 23271-23274 VBP denotes are
T13368 23228-23230 IN denotes of
T13369 23231-23234 DT denotes the
T13370 23263-23270 NNS denotes defects
T13371 23235-23244 JJ denotes pulmonary
T13372 23245-23248 CC denotes and
T13373 23249-23262 JJ denotes diaphragmatic
T13374 23275-23282 JJ denotes similar
T13375 23283-23290 IN denotes between
T13376 23291-23296 NN denotes mouse
T13377 23297-23300 CC denotes and
T13378 23301-23306 JJ denotes human
T13379 23306-23308 , denotes ,
T13380 23308-23310 PRP denotes we
T13381 23319-23323 IN denotes that
T13382 23346-23348 VBZ denotes is
T13383 23324-23328 DT denotes this
T13384 23329-23337 NN denotes mutation
T13385 23338-23340 IN denotes in
T13386 23341-23345 NN denotes FOG2
T13387 23349-23352 DT denotes the
T13388 23368-23373 NN denotes cause
T13389 23353-23358 JJ denotes first
T13390 23359-23367 VBN denotes reported
T13391 23374-23376 IN denotes of
T13392 23377-23378 DT denotes a
T13393 23427-23433 NN denotes defect
T13394 23379-23384 JJ denotes human
T13395 23385-23398 JJ denotes developmental
T13396 23399-23412 JJ denotes diaphragmatic
T13397 23413-23416 CC denotes and
T13398 23417-23426 JJ denotes pulmonary
T13399 23433-23434 . denotes .
T13400 23434-23530 sentence denotes In contrast to the affected child, mice heterozygous for a null mutation of Fog2 appear normal.
T13401 23435-23437 IN denotes In
T13402 23516-23522 VBP denotes appear
T13403 23438-23446 NN denotes contrast
T13404 23447-23449 IN denotes to
T13405 23450-23453 DT denotes the
T13406 23463-23468 NN denotes child
T13407 23454-23462 VBN denotes affected
T13408 23468-23470 , denotes ,
T13409 23470-23474 NNS denotes mice
T13410 23475-23487 JJ denotes heterozygous
T13411 23488-23491 IN denotes for
T13412 23492-23493 DT denotes a
T13413 23499-23507 NN denotes mutation
T13414 23494-23498 JJ denotes null
T13415 23508-23510 IN denotes of
T13416 23511-23515 NN denotes Fog2
T13417 23523-23529 JJ denotes normal
T13418 23529-23530 . denotes .
T13419 23530-23701 sentence denotes However, there is ample precedent for the observation that haploinsufficiency of a gene with developmental functions is much less well tolerated in humans than mice [41].
T13420 23531-23538 RB denotes However
T13421 23546-23548 VBZ denotes is
T13422 23538-23540 , denotes ,
T13423 23540-23545 EX denotes there
T13424 23549-23554 JJ denotes ample
T13425 23555-23564 NN denotes precedent
T13426 23565-23568 IN denotes for
T13427 23569-23572 DT denotes the
T13428 23573-23584 NN denotes observation
T13429 23585-23589 IN denotes that
T13430 23648-23650 VBZ denotes is
T13431 23590-23608 NN denotes haploinsufficiency
T13432 23609-23611 IN denotes of
T13433 23612-23613 DT denotes a
T13434 23614-23618 NN denotes gene
T13435 23619-23623 IN denotes with
T13436 23624-23637 JJ denotes developmental
T13437 23638-23647 NNS denotes functions
T13438 23651-23655 RB denotes much
T13439 23656-23660 RBR denotes less
T13440 23661-23665 RB denotes well
T13441 23666-23675 VBN denotes tolerated
T13442 23676-23678 IN denotes in
T13443 23679-23685 NNS denotes humans
T13444 23686-23690 IN denotes than
T13445 23691-23695 NNS denotes mice
T13446 23696-23697 -LRB- denotes [
T13447 23697-23699 CD denotes 41
T13448 23699-23700 -RRB- denotes ]
T13449 23700-23701 . denotes .
T13450 23701-23850 sentence denotes It is unclear how the Fog2 diaphragmatic defect relates to the more common Bochdalek CDH, as the pathogenic mechanisms for both are largely unknown.
T13451 23702-23704 PRP denotes It
T13452 23705-23707 VBZ denotes is
T13453 23708-23715 JJ denotes unclear
T13454 23716-23719 WRB denotes how
T13455 23750-23757 VBZ denotes relates
T13456 23720-23723 DT denotes the
T13457 23743-23749 NN denotes defect
T13458 23724-23728 NN denotes Fog2
T13459 23729-23742 JJ denotes diaphragmatic
T13460 23758-23760 IN denotes to
T13461 23761-23764 DT denotes the
T13462 23787-23790 NN denotes CDH
T13463 23765-23769 RBR denotes more
T13464 23770-23776 JJ denotes common
T13465 23777-23786 NNP denotes Bochdalek
T13466 23790-23792 , denotes ,
T13467 23792-23794 IN denotes as
T13468 23830-23833 VBP denotes are
T13469 23795-23798 DT denotes the
T13470 23810-23820 NNS denotes mechanisms
T13471 23799-23809 JJ denotes pathogenic
T13472 23821-23824 IN denotes for
T13473 23825-23829 DT denotes both
T13474 23834-23841 RB denotes largely
T13475 23842-23849 JJ denotes unknown
T13476 23849-23850 . denotes .
T13477 23850-23962 sentence denotes Muscle precursors destined to populate the diaphragm migrate from the lateral dermomyotome of cervical somites.
T13478 23851-23857 NN denotes Muscle
T13479 23858-23868 NNS denotes precursors
T13480 23904-23911 VBP denotes migrate
T13481 23869-23877 VBN denotes destined
T13482 23878-23880 TO denotes to
T13483 23881-23889 VB denotes populate
T13484 23890-23893 DT denotes the
T13485 23894-23903 NN denotes diaphragm
T13486 23912-23916 IN denotes from
T13487 23917-23920 DT denotes the
T13488 23929-23941 NN denotes dermomyotome
T13489 23921-23928 JJ denotes lateral
T13490 23942-23944 IN denotes of
T13491 23945-23953 JJ denotes cervical
T13492 23954-23961 NNS denotes somites
T13493 23961-23962 . denotes .
T13494 23962-24176 sentence denotes Prior to migration onto the diaphragm, they populate the PPF, a wedge-shaped tissue that tapers medially from the lateral body wall to the esophageal mesentery and fuses ventrally with the septum transversum [42].
T13495 23963-23968 RB denotes Prior
T13496 23969-23971 IN denotes to
T13497 24007-24015 VBP denotes populate
T13498 23972-23981 NN denotes migration
T13499 23982-23986 IN denotes onto
T13500 23987-23990 DT denotes the
T13501 23991-24000 NN denotes diaphragm
T13502 24000-24002 , denotes ,
T13503 24002-24006 PRP denotes they
T13504 24016-24019 DT denotes the
T13505 24020-24023 NN denotes PPF
T13506 24023-24025 , denotes ,
T13507 24025-24026 DT denotes a
T13508 24040-24046 NN denotes tissue
T13509 24027-24032 NN denotes wedge
T13510 24033-24039 VBN denotes shaped
T13511 24032-24033 HYPH denotes -
T13512 24047-24051 WDT denotes that
T13513 24052-24058 VBZ denotes tapers
T13514 24059-24067 RB denotes medially
T13515 24068-24072 IN denotes from
T13516 24073-24076 DT denotes the
T13517 24090-24094 NN denotes wall
T13518 24077-24084 JJ denotes lateral
T13519 24085-24089 NN denotes body
T13520 24095-24097 IN denotes to
T13521 24098-24101 DT denotes the
T13522 24113-24122 NN denotes mesentery
T13523 24102-24112 JJ denotes esophageal
T13524 24123-24126 CC denotes and
T13525 24127-24132 VBZ denotes fuses
T13526 24133-24142 RB denotes ventrally
T13527 24143-24147 IN denotes with
T13528 24148-24151 DT denotes the
T13529 24159-24170 NN denotes transversum
T13530 24152-24158 NN denotes septum
T13531 24171-24172 -LRB- denotes [
T13532 24172-24174 CD denotes 42
T13533 24174-24175 -RRB- denotes ]
T13534 24175-24176 . denotes .
T13535 24176-24368 sentence denotes Muscle precursors reach the PPF by E11, where they proliferate, differentiate, and then migrate toward the dorsolateral costal, sternal costal, and crural regions of the developing diaphragm.
T13536 24177-24183 NN denotes Muscle
T13537 24184-24194 NNS denotes precursors
T13538 24195-24200 VBP denotes reach
T13539 24201-24204 DT denotes the
T13540 24205-24208 NN denotes PPF
T13541 24209-24211 IN denotes by
T13542 24212-24215 NN denotes E11
T13543 24215-24217 , denotes ,
T13544 24217-24222 WRB denotes where
T13545 24228-24239 VBP denotes proliferate
T13546 24223-24227 PRP denotes they
T13547 24239-24241 , denotes ,
T13548 24241-24254 VBP denotes differentiate
T13549 24254-24256 , denotes ,
T13550 24256-24259 CC denotes and
T13551 24260-24264 RB denotes then
T13552 24265-24272 VBP denotes migrate
T13553 24273-24279 IN denotes toward
T13554 24280-24283 DT denotes the
T13555 24332-24339 NNS denotes regions
T13556 24284-24296 JJ denotes dorsolateral
T13557 24297-24303 JJ denotes costal
T13558 24303-24305 , denotes ,
T13559 24305-24312 JJ denotes sternal
T13560 24313-24319 JJ denotes costal
T13561 24319-24321 , denotes ,
T13562 24321-24324 CC denotes and
T13563 24325-24331 JJ denotes crural
T13564 24340-24342 IN denotes of
T13565 24343-24346 DT denotes the
T13566 24358-24367 NN denotes diaphragm
T13567 24347-24357 VBG denotes developing
T13568 24367-24368 . denotes .
T13569 24368-24470 sentence denotes Thus, a defect in PPF formation subsequently results in the abnormal formation of the diaphragm [43].
T13570 24369-24373 RB denotes Thus
T13571 24414-24421 VBZ denotes results
T13572 24373-24375 , denotes ,
T13573 24375-24376 DT denotes a
T13574 24377-24383 NN denotes defect
T13575 24384-24386 IN denotes in
T13576 24387-24390 NN denotes PPF
T13577 24391-24400 NN denotes formation
T13578 24401-24413 RB denotes subsequently
T13579 24422-24424 IN denotes in
T13580 24425-24428 DT denotes the
T13581 24438-24447 NN denotes formation
T13582 24429-24437 JJ denotes abnormal
T13583 24448-24450 IN denotes of
T13584 24451-24454 DT denotes the
T13585 24455-24464 NN denotes diaphragm
T13586 24465-24466 -LRB- denotes [
T13587 24466-24468 CD denotes 43
T13588 24468-24469 -RRB- denotes ]
T13589 24469-24470 . denotes .
T13590 24470-24643 sentence denotes We have shown that the Fog2 mutant does have an abnormal pattern of HGF expression in the region through which muscle precursor cells migrate onto the developing diaphragm.
T13591 24471-24473 PRP denotes We
T13592 24479-24484 VBN denotes shown
T13593 24474-24478 VBP denotes have
T13594 24485-24489 IN denotes that
T13595 24511-24515 VB denotes have
T13596 24490-24493 DT denotes the
T13597 24499-24505 NN denotes mutant
T13598 24494-24498 NN denotes Fog2
T13599 24506-24510 VBZ denotes does
T13600 24516-24518 DT denotes an
T13601 24528-24535 NN denotes pattern
T13602 24519-24527 JJ denotes abnormal
T13603 24536-24538 IN denotes of
T13604 24539-24542 NN denotes HGF
T13605 24543-24553 NN denotes expression
T13606 24554-24556 IN denotes in
T13607 24557-24560 DT denotes the
T13608 24561-24567 NN denotes region
T13609 24568-24575 IN denotes through
T13610 24605-24612 VBP denotes migrate
T13611 24576-24581 WDT denotes which
T13612 24582-24588 NN denotes muscle
T13613 24599-24604 NNS denotes cells
T13614 24589-24598 NN denotes precursor
T13615 24613-24617 IN denotes onto
T13616 24618-24621 DT denotes the
T13617 24633-24642 NN denotes diaphragm
T13618 24622-24632 VBG denotes developing
T13619 24642-24643 . denotes .
T13620 24643-24748 sentence denotes This finding may account for the abnormally patterned muscle that develops in the Fog2 mutant diaphragm.
T13621 24644-24648 DT denotes This
T13622 24649-24656 NN denotes finding
T13623 24661-24668 VB denotes account
T13624 24657-24660 MD denotes may
T13625 24669-24672 IN denotes for
T13626 24673-24676 DT denotes the
T13627 24698-24704 NN denotes muscle
T13628 24677-24687 RB denotes abnormally
T13629 24688-24697 VBN denotes patterned
T13630 24705-24709 WDT denotes that
T13631 24710-24718 VBZ denotes develops
T13632 24719-24721 IN denotes in
T13633 24722-24725 DT denotes the
T13634 24738-24747 NN denotes diaphragm
T13635 24726-24730 NN denotes Fog2
T13636 24731-24737 NN denotes mutant
T13637 24747-24748 . denotes .
T13638 24748-25064 sentence denotes Although Pax3 and MyoD expression is detected in the PPF, a detailed analysis of transcription factors responsible for muscle precursor cell migration and differentiation will need to be completed both in the PPF and along the pathway of muscle precursor cell migration between the PPF and the membranous diaphragm.
T13639 24749-24757 IN denotes Although
T13640 24786-24794 VBN denotes detected
T13641 24758-24762 NN denotes Pax3
T13642 24772-24782 NN denotes expression
T13643 24763-24766 CC denotes and
T13644 24767-24771 NN denotes MyoD
T13645 24783-24785 VBZ denotes is
T13646 24925-24929 VB denotes need
T13647 24795-24797 IN denotes in
T13648 24798-24801 DT denotes the
T13649 24802-24805 NN denotes PPF
T13650 24805-24807 , denotes ,
T13651 24807-24808 DT denotes a
T13652 24818-24826 NN denotes analysis
T13653 24809-24817 JJ denotes detailed
T13654 24827-24829 IN denotes of
T13655 24830-24843 NN denotes transcription
T13656 24844-24851 NNS denotes factors
T13657 24852-24863 JJ denotes responsible
T13658 24864-24867 IN denotes for
T13659 24868-24874 NN denotes muscle
T13660 24885-24889 NN denotes cell
T13661 24875-24884 NN denotes precursor
T13662 24890-24899 NN denotes migration
T13663 24900-24903 CC denotes and
T13664 24904-24919 NN denotes differentiation
T13665 24920-24924 MD denotes will
T13666 24930-24932 TO denotes to
T13667 24936-24945 VBN denotes completed
T13668 24933-24935 VB denotes be
T13669 24946-24950 CC denotes both
T13670 24951-24953 IN denotes in
T13671 24954-24957 DT denotes the
T13672 24958-24961 NN denotes PPF
T13673 24962-24965 CC denotes and
T13674 24966-24971 IN denotes along
T13675 24972-24975 DT denotes the
T13676 24976-24983 NN denotes pathway
T13677 24984-24986 IN denotes of
T13678 24987-24993 NN denotes muscle
T13679 25004-25008 NN denotes cell
T13680 24994-25003 NN denotes precursor
T13681 25009-25018 NN denotes migration
T13682 25019-25026 IN denotes between
T13683 25027-25030 DT denotes the
T13684 25031-25034 NN denotes PPF
T13685 25035-25038 CC denotes and
T13686 25039-25042 DT denotes the
T13687 25054-25063 NN denotes diaphragm
T13688 25043-25053 JJ denotes membranous
T13689 25063-25064 . denotes .
T13690 25064-25188 sentence denotes Fog2 can interact with any of the Gata factors, Gatas 1–6, as well as other transcription factors such as CoupTFII [44,45].
T13691 25065-25069 NN denotes Fog2
T13692 25074-25082 VB denotes interact
T13693 25070-25073 MD denotes can
T13694 25083-25087 IN denotes with
T13695 25088-25091 DT denotes any
T13696 25092-25094 IN denotes of
T13697 25095-25098 DT denotes the
T13698 25104-25111 NNS denotes factors
T13699 25099-25103 NN denotes Gata
T13700 25111-25113 , denotes ,
T13701 25113-25118 NNS denotes Gatas
T13702 25119-25120 CD denotes 1
T13703 25120-25121 SYM denotes –
T13704 25121-25122 CD denotes 6
T13705 25122-25124 , denotes ,
T13706 25124-25126 RB denotes as
T13707 25132-25134 IN denotes as
T13708 25127-25131 RB denotes well
T13709 25135-25140 JJ denotes other
T13710 25155-25162 NNS denotes factors
T13711 25141-25154 NN denotes transcription
T13712 25163-25167 JJ denotes such
T13713 25168-25170 IN denotes as
T13714 25171-25179 NN denotes CoupTFII
T13715 25180-25181 -LRB- denotes [
T13716 25184-25186 CD denotes 45
T13717 25181-25183 CD denotes 44
T13718 25183-25184 , denotes ,
T13719 25186-25187 -RRB- denotes ]
T13720 25187-25188 . denotes .
T13721 25188-25366 sentence denotes It is known that a Fog2–Gata4 interaction is critical for normal cardiac and gonadal development, but interacting factors in the lung and diaphragm have not yet been determined.
T13722 25189-25191 PRP denotes It
T13723 25195-25200 VBN denotes known
T13724 25192-25194 VBZ denotes is
T13725 25201-25205 IN denotes that
T13726 25231-25233 VBZ denotes is
T13727 25206-25207 DT denotes a
T13728 25219-25230 NN denotes interaction
T13729 25208-25212 NN denotes Fog2
T13730 25213-25218 NN denotes Gata4
T13731 25212-25213 HYPH denotes –
T13732 25234-25242 JJ denotes critical
T13733 25243-25246 IN denotes for
T13734 25247-25253 JJ denotes normal
T13735 25274-25285 NN denotes development
T13736 25254-25261 JJ denotes cardiac
T13737 25262-25265 CC denotes and
T13738 25266-25273 JJ denotes gonadal
T13739 25285-25287 , denotes ,
T13740 25287-25290 CC denotes but
T13741 25291-25302 VBG denotes interacting
T13742 25303-25310 NNS denotes factors
T13743 25355-25365 VBN denotes determined
T13744 25311-25313 IN denotes in
T13745 25314-25317 DT denotes the
T13746 25318-25322 NN denotes lung
T13747 25323-25326 CC denotes and
T13748 25327-25336 NN denotes diaphragm
T13749 25337-25341 VBP denotes have
T13750 25342-25345 RB denotes not
T13751 25346-25349 RB denotes yet
T13752 25350-25354 VBN denotes been
T13753 25365-25366 . denotes .
T13754 25366-25483 sentence denotes The severity of pulmonary hypoplasia in the patient we report was out of proportion to that of the diaphragm defect.
T13755 25367-25370 DT denotes The
T13756 25371-25379 NN denotes severity
T13757 25429-25432 VBD denotes was
T13758 25380-25382 IN denotes of
T13759 25383-25392 JJ denotes pulmonary
T13760 25393-25403 NN denotes hypoplasia
T13761 25404-25406 IN denotes in
T13762 25407-25410 DT denotes the
T13763 25411-25418 NN denotes patient
T13764 25419-25421 PRP denotes we
T13765 25422-25428 VBP denotes report
T13766 25433-25436 IN denotes out
T13767 25437-25439 IN denotes of
T13768 25440-25450 NN denotes proportion
T13769 25451-25453 IN denotes to
T13770 25454-25458 DT denotes that
T13771 25459-25461 IN denotes of
T13772 25462-25465 DT denotes the
T13773 25476-25482 NN denotes defect
T13774 25466-25475 NN denotes diaphragm
T13775 25482-25483 . denotes .
T13776 25483-25737 sentence denotes Pulmonary hypoplasia is associated with abnormal diaphragmatic anatomy or function, and is known to occur as a secondary developmental defect in models of diaphragmatic dysfunction such as complete amuscularization [17] or phrenic nerve disruption [46].
T13777 25484-25493 JJ denotes Pulmonary
T13778 25494-25504 NN denotes hypoplasia
T13779 25505-25507 VBZ denotes is
T13780 25508-25518 JJ denotes associated
T13781 25519-25523 IN denotes with
T13782 25524-25532 JJ denotes abnormal
T13783 25547-25554 NN denotes anatomy
T13784 25533-25546 JJ denotes diaphragmatic
T13785 25555-25557 CC denotes or
T13786 25558-25566 NN denotes function
T13787 25566-25568 , denotes ,
T13788 25568-25571 CC denotes and
T13789 25572-25574 VBZ denotes is
T13790 25575-25580 VBN denotes known
T13791 25581-25583 TO denotes to
T13792 25584-25589 VB denotes occur
T13793 25590-25592 IN denotes as
T13794 25593-25594 DT denotes a
T13795 25619-25625 NN denotes defect
T13796 25595-25604 JJ denotes secondary
T13797 25605-25618 JJ denotes developmental
T13798 25626-25628 IN denotes in
T13799 25629-25635 NNS denotes models
T13800 25636-25638 IN denotes of
T13801 25639-25652 JJ denotes diaphragmatic
T13802 25653-25664 NN denotes dysfunction
T13803 25665-25669 JJ denotes such
T13804 25670-25672 IN denotes as
T13805 25673-25681 JJ denotes complete
T13806 25682-25698 NN denotes amuscularization
T13807 25699-25700 -LRB- denotes [
T13808 25700-25702 CD denotes 17
T13809 25702-25703 -RRB- denotes ]
T13810 25704-25706 CC denotes or
T13811 25707-25714 JJ denotes phrenic
T13812 25715-25720 NN denotes nerve
T13813 25721-25731 NN denotes disruption
T13814 25732-25733 -LRB- denotes [
T13815 25733-25735 CD denotes 46
T13816 25735-25736 -RRB- denotes ]
T13817 25736-25737 . denotes .
T13818 25737-25843 sentence denotes It occurs in a surgical model of CDH in which a hernia is physically created in an in utero lamb [47,48].
T13819 25738-25740 PRP denotes It
T13820 25741-25747 VBZ denotes occurs
T13821 25748-25750 IN denotes in
T13822 25751-25752 DT denotes a
T13823 25762-25767 NN denotes model
T13824 25753-25761 JJ denotes surgical
T13825 25768-25770 IN denotes of
T13826 25771-25774 NN denotes CDH
T13827 25775-25777 IN denotes in
T13828 25807-25814 VBN denotes created
T13829 25778-25783 WDT denotes which
T13830 25784-25785 DT denotes a
T13831 25786-25792 NN denotes hernia
T13832 25793-25795 VBZ denotes is
T13833 25796-25806 RB denotes physically
T13834 25815-25817 IN denotes in
T13835 25818-25820 DT denotes an
T13836 25830-25834 NN denotes lamb
T13837 25821-25823 FW denotes in
T13838 25824-25829 FW denotes utero
T13839 25835-25836 -LRB- denotes [
T13840 25839-25841 CD denotes 48
T13841 25836-25838 CD denotes 47
T13842 25838-25839 , denotes ,
T13843 25841-25842 -RRB- denotes ]
T13844 25842-25843 . denotes .
T13845 25843-26123 sentence denotes However, the possibility that primary pulmonary developmental abnormalities occur with, rather than secondary to, diaphragmatic defects has been suggested by others based on a teratogenic model of CDH [49–51] and has long been suspected by clinicians who care for these patients.
T13846 25844-25851 RB denotes However
T13847 25989-25998 VBN denotes suggested
T13848 25851-25853 , denotes ,
T13849 25853-25856 DT denotes the
T13850 25857-25868 NN denotes possibility
T13851 25869-25873 IN denotes that
T13852 25920-25925 VBP denotes occur
T13853 25874-25881 JJ denotes primary
T13854 25906-25919 NNS denotes abnormalities
T13855 25882-25891 JJ denotes pulmonary
T13856 25892-25905 JJ denotes developmental
T13857 25926-25930 IN denotes with
T13858 25930-25932 , denotes ,
T13859 25932-25938 RB denotes rather
T13860 25939-25943 IN denotes than
T13861 25944-25953 RB denotes secondary
T13862 25954-25956 IN denotes to
T13863 25956-25958 , denotes ,
T13864 25958-25971 JJ denotes diaphragmatic
T13865 25972-25979 NNS denotes defects
T13866 25980-25983 VBZ denotes has
T13867 25984-25988 VBN denotes been
T13868 25999-26001 IN denotes by
T13869 26002-26008 NNS denotes others
T13870 26009-26014 VBN denotes based
T13871 26015-26017 IN denotes on
T13872 26018-26019 DT denotes a
T13873 26032-26037 NN denotes model
T13874 26020-26031 JJ denotes teratogenic
T13875 26038-26040 IN denotes of
T13876 26041-26044 NN denotes CDH
T13877 26045-26046 -LRB- denotes [
T13878 26046-26048 CD denotes 49
T13879 26048-26049 SYM denotes –
T13880 26049-26051 CD denotes 51
T13881 26051-26052 -RRB- denotes ]
T13882 26053-26056 CC denotes and
T13883 26057-26060 VBZ denotes has
T13884 26071-26080 VBN denotes suspected
T13885 26061-26065 RB denotes long
T13886 26066-26070 VBN denotes been
T13887 26081-26083 IN denotes by
T13888 26084-26094 NNS denotes clinicians
T13889 26095-26098 WP denotes who
T13890 26099-26103 VBP denotes care
T13891 26104-26107 IN denotes for
T13892 26108-26113 DT denotes these
T13893 26114-26122 NNS denotes patients
T13894 26122-26123 . denotes .
T13895 26123-26317 sentence denotes In addition, the high incidence of lobar abnormalities associated with CDH [52] supports the possibility that this disorder can be associated with a primary developmental pulmonary abnormality.
T13896 26124-26126 IN denotes In
T13897 26204-26212 VBZ denotes supports
T13898 26127-26135 NN denotes addition
T13899 26135-26137 , denotes ,
T13900 26137-26140 DT denotes the
T13901 26146-26155 NN denotes incidence
T13902 26141-26145 JJ denotes high
T13903 26156-26158 IN denotes of
T13904 26159-26164 NN denotes lobar
T13905 26165-26178 NNS denotes abnormalities
T13906 26179-26189 JJ denotes associated
T13907 26190-26194 IN denotes with
T13908 26195-26198 NN denotes CDH
T13909 26199-26200 -LRB- denotes [
T13910 26200-26202 CD denotes 52
T13911 26202-26203 -RRB- denotes ]
T13912 26213-26216 DT denotes the
T13913 26217-26228 NN denotes possibility
T13914 26229-26233 IN denotes that
T13915 26255-26265 VBN denotes associated
T13916 26234-26238 DT denotes this
T13917 26239-26247 NN denotes disorder
T13918 26248-26251 MD denotes can
T13919 26252-26254 VB denotes be
T13920 26266-26270 IN denotes with
T13921 26271-26272 DT denotes a
T13922 26305-26316 NN denotes abnormality
T13923 26273-26280 JJ denotes primary
T13924 26281-26294 JJ denotes developmental
T13925 26295-26304 JJ denotes pulmonary
T13926 26316-26317 . denotes .
T13927 26317-26518 sentence denotes Our analysis of mice carrying mutations of Fog2 proves that there is a primary defect in lung development that results in specific loss of the accessory lobe and partial loss of the right middle lobe.
T13928 26318-26321 PRP$ denotes Our
T13929 26322-26330 NN denotes analysis
T13930 26366-26372 VBZ denotes proves
T13931 26331-26333 IN denotes of
T13932 26334-26338 NNS denotes mice
T13933 26339-26347 VBG denotes carrying
T13934 26348-26357 NNS denotes mutations
T13935 26358-26360 IN denotes of
T13936 26361-26365 NN denotes Fog2
T13937 26373-26377 IN denotes that
T13938 26384-26386 VBZ denotes is
T13939 26378-26383 EX denotes there
T13940 26387-26388 DT denotes a
T13941 26397-26403 NN denotes defect
T13942 26389-26396 JJ denotes primary
T13943 26404-26406 IN denotes in
T13944 26407-26411 NN denotes lung
T13945 26412-26423 NN denotes development
T13946 26424-26428 WDT denotes that
T13947 26429-26436 VBZ denotes results
T13948 26437-26439 IN denotes in
T13949 26440-26448 JJ denotes specific
T13950 26449-26453 NN denotes loss
T13951 26454-26456 IN denotes of
T13952 26457-26460 DT denotes the
T13953 26471-26475 NN denotes lobe
T13954 26461-26470 JJ denotes accessory
T13955 26476-26479 CC denotes and
T13956 26480-26487 JJ denotes partial
T13957 26488-26492 NN denotes loss
T13958 26493-26495 IN denotes of
T13959 26496-26499 DT denotes the
T13960 26513-26517 NN denotes lobe
T13961 26500-26505 JJ denotes right
T13962 26506-26512 JJ denotes middle
T13963 26517-26518 . denotes .
T13964 26518-26621 sentence denotes The specific lobar defects prompted us to evaluate Fog2 expression at the time of early lobar budding.
T13965 26519-26522 DT denotes The
T13966 26538-26545 NNS denotes defects
T13967 26523-26531 JJ denotes specific
T13968 26532-26537 NN denotes lobar
T13969 26546-26554 VBD denotes prompted
T13970 26555-26557 PRP denotes us
T13971 26558-26560 TO denotes to
T13972 26561-26569 VB denotes evaluate
T13973 26570-26574 NN denotes Fog2
T13974 26575-26585 NN denotes expression
T13975 26586-26588 IN denotes at
T13976 26589-26592 DT denotes the
T13977 26593-26597 NN denotes time
T13978 26598-26600 IN denotes of
T13979 26601-26606 JJ denotes early
T13980 26613-26620 NN denotes budding
T13981 26607-26612 NN denotes lobar
T13982 26620-26621 . denotes .
T13983 26621-26854 sentence denotes While Fog2 expression is diffuse in the pulmonary mesenchyme after lobar structure is well established (E12.5), it is more focally expressed in the mesenchyme surrounding the right middle lobe and accessory buds as these lobes form.
T13984 26622-26627 IN denotes While
T13985 26644-26646 VBZ denotes is
T13986 26628-26632 NN denotes Fog2
T13987 26633-26643 NN denotes expression
T13988 26753-26762 VBN denotes expressed
T13989 26647-26654 JJ denotes diffuse
T13990 26655-26657 IN denotes in
T13991 26658-26661 DT denotes the
T13992 26672-26682 NN denotes mesenchyme
T13993 26662-26671 JJ denotes pulmonary
T13994 26683-26688 IN denotes after
T13995 26705-26707 VBZ denotes is
T13996 26689-26694 NN denotes lobar
T13997 26695-26704 NN denotes structure
T13998 26708-26712 RB denotes well
T13999 26713-26724 VBN denotes established
T14000 26725-26726 -LRB- denotes (
T14001 26726-26731 NN denotes E12.5
T14002 26731-26732 -RRB- denotes )
T14003 26732-26734 , denotes ,
T14004 26734-26736 PRP denotes it
T14005 26737-26739 VBZ denotes is
T14006 26740-26744 RBR denotes more
T14007 26745-26752 RB denotes focally
T14008 26763-26765 IN denotes in
T14009 26766-26769 DT denotes the
T14010 26770-26780 NN denotes mesenchyme
T14011 26781-26792 VBG denotes surrounding
T14012 26793-26796 DT denotes the
T14013 26810-26814 NN denotes lobe
T14014 26797-26802 JJ denotes right
T14015 26803-26809 JJ denotes middle
T14016 26815-26818 CC denotes and
T14017 26819-26828 JJ denotes accessory
T14018 26829-26833 NNS denotes buds
T14019 26834-26836 IN denotes as
T14020 26849-26853 VBP denotes form
T14021 26837-26842 DT denotes these
T14022 26843-26848 NNS denotes lobes
T14023 26853-26854 . denotes .
T14024 26854-27014 sentence denotes This matches the phenotype of right middle lobe and accessory lobe loss, and suggests that Fog2 has a specific patterning role in establishment of these lobes.
T14025 26855-26859 DT denotes This
T14026 26860-26867 VBZ denotes matches
T14027 26868-26871 DT denotes the
T14028 26872-26881 NN denotes phenotype
T14029 26882-26884 IN denotes of
T14030 26885-26890 JJ denotes right
T14031 26898-26902 NN denotes lobe
T14032 26891-26897 JJ denotes middle
T14033 26922-26926 NN denotes loss
T14034 26903-26906 CC denotes and
T14035 26907-26916 JJ denotes accessory
T14036 26917-26921 NN denotes lobe
T14037 26926-26928 , denotes ,
T14038 26928-26931 CC denotes and
T14039 26932-26940 VBZ denotes suggests
T14040 26941-26945 IN denotes that
T14041 26951-26954 VBZ denotes has
T14042 26946-26950 NN denotes Fog2
T14043 26955-26956 DT denotes a
T14044 26977-26981 NN denotes role
T14045 26957-26965 JJ denotes specific
T14046 26966-26976 NN denotes patterning
T14047 26982-26984 IN denotes in
T14048 26985-26998 NN denotes establishment
T14049 26999-27001 IN denotes of
T14050 27002-27007 DT denotes these
T14051 27008-27013 NNS denotes lobes
T14052 27013-27014 . denotes .
T14053 27014-27186 sentence denotes It is less clear whether loss of Fog2 results in a global branching defect, as Fog2 lungs appear to have a slight developmental delay, which could result from many causes.
T14054 27015-27017 PRP denotes It
T14055 27018-27020 VBZ denotes is
T14056 27021-27025 RBR denotes less
T14057 27026-27031 JJ denotes clear
T14058 27032-27039 IN denotes whether
T14059 27053-27060 VBZ denotes results
T14060 27040-27044 NN denotes loss
T14061 27045-27047 IN denotes of
T14062 27048-27052 NN denotes Fog2
T14063 27061-27063 IN denotes in
T14064 27064-27065 DT denotes a
T14065 27083-27089 NN denotes defect
T14066 27066-27072 JJ denotes global
T14067 27073-27082 NN denotes branching
T14068 27089-27091 , denotes ,
T14069 27091-27093 IN denotes as
T14070 27105-27111 VBP denotes appear
T14071 27094-27098 NN denotes Fog2
T14072 27099-27104 NNS denotes lungs
T14073 27112-27114 TO denotes to
T14074 27115-27119 VB denotes have
T14075 27120-27121 DT denotes a
T14076 27143-27148 NN denotes delay
T14077 27122-27128 JJ denotes slight
T14078 27129-27142 JJ denotes developmental
T14079 27148-27150 , denotes ,
T14080 27150-27155 WDT denotes which
T14081 27162-27168 VB denotes result
T14082 27156-27161 MD denotes could
T14083 27169-27173 IN denotes from
T14084 27174-27178 JJ denotes many
T14085 27179-27185 NNS denotes causes
T14086 27185-27186 . denotes .
T14087 27186-27349 sentence denotes Cultured Fog2 lungs do develop an intricate branching pattern in the unaffected lobes that appears similar in the pattern to wild-type lungs after 5 d in culture.
T14088 27187-27195 VBN denotes Cultured
T14089 27201-27206 NNS denotes lungs
T14090 27196-27200 NN denotes Fog2
T14091 27210-27217 VB denotes develop
T14092 27207-27209 VBP denotes do
T14093 27218-27220 DT denotes an
T14094 27241-27248 NN denotes pattern
T14095 27221-27230 JJ denotes intricate
T14096 27231-27240 NN denotes branching
T14097 27249-27251 IN denotes in
T14098 27252-27255 DT denotes the
T14099 27267-27272 NNS denotes lobes
T14100 27256-27266 JJ denotes unaffected
T14101 27273-27277 WDT denotes that
T14102 27278-27285 VBZ denotes appears
T14103 27286-27293 JJ denotes similar
T14104 27294-27296 IN denotes in
T14105 27297-27300 DT denotes the
T14106 27301-27308 NN denotes pattern
T14107 27309-27311 IN denotes to
T14108 27312-27316 JJ denotes wild
T14109 27317-27321 NN denotes type
T14110 27316-27317 HYPH denotes -
T14111 27322-27327 NNS denotes lungs
T14112 27328-27333 IN denotes after
T14113 27334-27335 CD denotes 5
T14114 27336-27337 NN denotes d
T14115 27338-27340 IN denotes in
T14116 27341-27348 NN denotes culture
T14117 27348-27349 . denotes .
T14118 27349-27507 sentence denotes In this report, we show that a mutation of Fog2 in the mouse causes the phenotype of abnormal diaphragmatic muscularization and primary pulmonary hypoplasia.
T14119 27350-27352 IN denotes In
T14120 27369-27373 VBP denotes show
T14121 27353-27357 DT denotes this
T14122 27358-27364 NN denotes report
T14123 27364-27366 , denotes ,
T14124 27366-27368 PRP denotes we
T14125 27374-27378 IN denotes that
T14126 27411-27417 VBZ denotes causes
T14127 27379-27380 DT denotes a
T14128 27381-27389 NN denotes mutation
T14129 27390-27392 IN denotes of
T14130 27393-27397 NN denotes Fog2
T14131 27398-27400 IN denotes in
T14132 27401-27404 DT denotes the
T14133 27405-27410 NN denotes mouse
T14134 27418-27421 DT denotes the
T14135 27422-27431 NN denotes phenotype
T14136 27432-27434 IN denotes of
T14137 27435-27443 JJ denotes abnormal
T14138 27458-27473 NN denotes muscularization
T14139 27444-27457 JJ denotes diaphragmatic
T14140 27474-27477 CC denotes and
T14141 27478-27485 JJ denotes primary
T14142 27496-27506 NN denotes hypoplasia
T14143 27486-27495 JJ denotes pulmonary
T14144 27506-27507 . denotes .
T14145 27507-27644 sentence denotes We furthermore demonstrate that a mutation in this gene is associated with a lethal defect in lung and diaphragm development in a child.
T14146 27508-27510 PRP denotes We
T14147 27523-27534 VBP denotes demonstrate
T14148 27511-27522 RB denotes furthermore
T14149 27535-27539 IN denotes that
T14150 27564-27566 VBZ denotes is
T14151 27540-27541 DT denotes a
T14152 27542-27550 NN denotes mutation
T14153 27551-27553 IN denotes in
T14154 27554-27558 DT denotes this
T14155 27559-27563 NN denotes gene
T14156 27567-27577 JJ denotes associated
T14157 27578-27582 IN denotes with
T14158 27583-27584 DT denotes a
T14159 27592-27598 NN denotes defect
T14160 27585-27591 JJ denotes lethal
T14161 27599-27601 IN denotes in
T14162 27602-27606 NN denotes lung
T14163 27621-27632 NN denotes development
T14164 27607-27610 CC denotes and
T14165 27611-27620 NN denotes diaphragm
T14166 27633-27635 IN denotes in
T14167 27636-27637 DT denotes a
T14168 27638-27643 NN denotes child
T14169 27643-27644 . denotes .
T14170 27644-27827 sentence denotes It is notable that, despite extensive analysis of Fog2 biology and the generation of a Fog2 knock-out mouse, its role in diaphragm and lung development was previously not recognized.
T14171 27645-27647 PRP denotes It
T14172 27648-27650 VBZ denotes is
T14173 27651-27658 JJ denotes notable
T14174 27659-27663 IN denotes that
T14175 27816-27826 VBN denotes recognized
T14176 27663-27665 , denotes ,
T14177 27665-27672 IN denotes despite
T14178 27673-27682 JJ denotes extensive
T14179 27683-27691 NN denotes analysis
T14180 27692-27694 IN denotes of
T14181 27695-27699 NN denotes Fog2
T14182 27700-27707 NN denotes biology
T14183 27708-27711 CC denotes and
T14184 27712-27715 DT denotes the
T14185 27716-27726 NN denotes generation
T14186 27727-27729 IN denotes of
T14187 27730-27731 DT denotes a
T14188 27747-27752 NN denotes mouse
T14189 27732-27736 NN denotes Fog2
T14190 27737-27742 VB denotes knock
T14191 27742-27743 HYPH denotes -
T14192 27743-27746 RP denotes out
T14193 27752-27754 , denotes ,
T14194 27754-27757 PRP$ denotes its
T14195 27758-27762 NN denotes role
T14196 27763-27765 IN denotes in
T14197 27766-27775 NN denotes diaphragm
T14198 27785-27796 NN denotes development
T14199 27776-27779 CC denotes and
T14200 27780-27784 NN denotes lung
T14201 27797-27800 VBD denotes was
T14202 27801-27811 RB denotes previously
T14203 27812-27815 RB denotes not
T14204 27826-27827 . denotes .
T14205 27827-28030 sentence denotes It is only as a consequence of phenotype-driven analyses such as those we are pursuing that one has the opportunity to assay all of the potential molecular derangements that may result in human disease.
T14206 27828-27830 PRP denotes It
T14207 27831-27833 VBZ denotes is
T14208 27834-27838 RB denotes only
T14209 27839-27841 IN denotes as
T14210 27842-27843 DT denotes a
T14211 27844-27855 NN denotes consequence
T14212 27856-27858 IN denotes of
T14213 27859-27868 NN denotes phenotype
T14214 27869-27875 VBN denotes driven
T14215 27868-27869 HYPH denotes -
T14216 27876-27884 NNS denotes analyses
T14217 27885-27889 JJ denotes such
T14218 27890-27892 IN denotes as
T14219 27893-27898 DT denotes those
T14220 27899-27901 PRP denotes we
T14221 27906-27914 VBG denotes pursuing
T14222 27902-27905 VBP denotes are
T14223 27915-27919 IN denotes that
T14224 27924-27927 VBZ denotes has
T14225 27920-27923 PRP denotes one
T14226 27928-27931 DT denotes the
T14227 27932-27943 NN denotes opportunity
T14228 27944-27946 TO denotes to
T14229 27947-27952 VB denotes assay
T14230 27953-27956 DT denotes all
T14231 27957-27959 IN denotes of
T14232 27960-27963 DT denotes the
T14233 27984-27996 NNS denotes derangements
T14234 27964-27973 JJ denotes potential
T14235 27974-27983 JJ denotes molecular
T14236 27997-28001 WDT denotes that
T14237 28006-28012 VB denotes result
T14238 28002-28005 MD denotes may
T14239 28013-28015 IN denotes in
T14240 28016-28021 JJ denotes human
T14241 28022-28029 NN denotes disease
T14242 28029-28030 . denotes .
T14396 28325-28332 JJ denotes Genetic
T14397 28333-28340 NN denotes mapping
T14398 28341-28343 IN denotes of
T14399 28344-28347 DT denotes the
T14400 28354-28362 NN denotes mutation
T14401 28348-28353 NN denotes mouse
T14402 28363-28366 NN denotes lil
T14403 28366-28367 . denotes .
T14404 28367-28424 sentence denotes The lil mutation was identified as described in results.
T14405 28368-28371 DT denotes The
T14406 28376-28384 NN denotes mutation
T14407 28372-28375 NN denotes lil
T14408 28389-28399 VBN denotes identified
T14409 28385-28388 VBD denotes was
T14410 28400-28402 IN denotes as
T14411 28403-28412 VBN denotes described
T14412 28413-28415 IN denotes in
T14413 28416-28423 NNS denotes results
T14414 28423-28424 . denotes .
T14415 28424-28561 sentence denotes Wild-type FVB/N and C57BL/6J mice used for genetic crosses were obtained from the Jackson Laboratory (Bar Harbor, Maine, United States).
T14416 28425-28429 JJ denotes Wild
T14417 28430-28434 NN denotes type
T14418 28429-28430 HYPH denotes -
T14419 28454-28458 NNS denotes mice
T14420 28435-28438 NN denotes FVB
T14421 28439-28440 NN denotes N
T14422 28438-28439 HYPH denotes /
T14423 28441-28444 CC denotes and
T14424 28445-28450 NN denotes C57BL
T14425 28451-28453 NN denotes 6J
T14426 28450-28451 HYPH denotes /
T14427 28489-28497 VBN denotes obtained
T14428 28459-28463 VBN denotes used
T14429 28464-28467 IN denotes for
T14430 28468-28475 JJ denotes genetic
T14431 28476-28483 NNS denotes crosses
T14432 28484-28488 VBD denotes were
T14433 28498-28502 IN denotes from
T14434 28503-28506 DT denotes the
T14435 28515-28525 NNP denotes Laboratory
T14436 28507-28514 NNP denotes Jackson
T14437 28526-28527 -LRB- denotes (
T14438 28531-28537 NNP denotes Harbor
T14439 28527-28530 NNP denotes Bar
T14440 28537-28539 , denotes ,
T14441 28539-28544 NNP denotes Maine
T14442 28544-28546 , denotes ,
T14443 28546-28552 NNP denotes United
T14444 28553-28559 NNP denotes States
T14445 28559-28560 -RRB- denotes )
T14446 28560-28561 . denotes .
T14447 28561-28676 sentence denotes Mice carrying a null mutation of Fog2 generated by gene targeting [16] were the generous gift of Dr. Stuart Orkin.
T14448 28562-28566 NNS denotes Mice
T14449 28633-28637 VBD denotes were
T14450 28567-28575 VBG denotes carrying
T14451 28576-28577 DT denotes a
T14452 28583-28591 NN denotes mutation
T14453 28578-28582 JJ denotes null
T14454 28592-28594 IN denotes of
T14455 28595-28599 NN denotes Fog2
T14456 28600-28609 VBN denotes generated
T14457 28610-28612 IN denotes by
T14458 28613-28617 NN denotes gene
T14459 28618-28627 NN denotes targeting
T14460 28628-28629 -LRB- denotes [
T14461 28629-28631 CD denotes 16
T14462 28631-28632 -RRB- denotes ]
T14463 28638-28641 DT denotes the
T14464 28651-28655 NN denotes gift
T14465 28642-28650 JJ denotes generous
T14466 28656-28658 IN denotes of
T14467 28659-28662 NNP denotes Dr.
T14468 28670-28675 NNP denotes Orkin
T14469 28663-28669 NNP denotes Stuart
T14470 28675-28676 . denotes .
T15313 28678-28691 JJ denotes Developmental
T15314 28692-28700 NN denotes analysis
T15315 28701-28703 IN denotes of
T15316 28704-28708 NNS denotes mice
T15317 28708-28709 . denotes .
T15318 28709-28778 sentence denotes Timed pregnancies were set up for collection of E11.5–E17.5 embryos.
T15319 28710-28715 JJ denotes Timed
T15320 28716-28727 NNS denotes pregnancies
T15321 28733-28736 VBN denotes set
T15322 28728-28732 VBD denotes were
T15323 28737-28739 RP denotes up
T15324 28740-28743 IN denotes for
T15325 28744-28754 NN denotes collection
T15326 28755-28757 IN denotes of
T15327 28758-28763 NN denotes E11.5
T15328 28770-28777 NNS denotes embryos
T15329 28763-28764 SYM denotes –
T15330 28764-28769 NN denotes E17.5
T15331 28777-28778 . denotes .
T15332 28778-28856 sentence denotes Embryos were fixed, dehydrated, and embedded in paraffin prior to sectioning.
T15333 28779-28786 NNS denotes Embryos
T15334 28792-28797 VBN denotes fixed
T15335 28787-28791 VBD denotes were
T15336 28797-28799 , denotes ,
T15337 28799-28809 VBN denotes dehydrated
T15338 28809-28811 , denotes ,
T15339 28811-28814 CC denotes and
T15340 28815-28823 VBN denotes embedded
T15341 28824-28826 IN denotes in
T15342 28827-28835 NN denotes paraffin
T15343 28836-28841 JJ denotes prior
T15344 28842-28844 IN denotes to
T15345 28845-28855 NN denotes sectioning
T15346 28855-28856 . denotes .
T15347 28856-28983 sentence denotes In older embryos, a median sternotomy was performed under microscopic guidance, and diaphragm, lungs, and heart were examined.
T15348 28857-28859 IN denotes In
T15349 28899-28908 VBN denotes performed
T15350 28860-28865 JJR denotes older
T15351 28866-28873 NNS denotes embryos
T15352 28873-28875 , denotes ,
T15353 28875-28876 DT denotes a
T15354 28884-28894 NN denotes sternotomy
T15355 28877-28883 JJ denotes median
T15356 28895-28898 VBD denotes was
T15357 28909-28914 IN denotes under
T15358 28915-28926 JJ denotes microscopic
T15359 28927-28935 NN denotes guidance
T15360 28935-28937 , denotes ,
T15361 28937-28940 CC denotes and
T15362 28941-28950 NN denotes diaphragm
T15363 28974-28982 VBN denotes examined
T15364 28950-28952 , denotes ,
T15365 28952-28957 NNS denotes lungs
T15366 28957-28959 , denotes ,
T15367 28959-28962 CC denotes and
T15368 28963-28968 NN denotes heart
T15369 28969-28973 VBD denotes were
T15370 28982-28983 . denotes .
T15371 28983-29045 sentence denotes The lungs and tracheobronchial tree were removed and weighed.
T15372 28984-28987 DT denotes The
T15373 28988-28993 NNS denotes lungs
T15374 29025-29032 VBN denotes removed
T15375 28994-28997 CC denotes and
T15376 28998-29014 JJ denotes tracheobronchial
T15377 29015-29019 NN denotes tree
T15378 29020-29024 VBD denotes were
T15379 29033-29036 CC denotes and
T15380 29037-29044 VBN denotes weighed
T15381 29044-29045 . denotes .
T15382 29045-29133 sentence denotes Whole diaphragms were isolated from fixed thoracic tissue from E15.5 and E17.5 embryos.
T15383 29046-29051 JJ denotes Whole
T15384 29052-29062 NNS denotes diaphragms
T15385 29068-29076 VBN denotes isolated
T15386 29063-29067 VBD denotes were
T15387 29077-29081 IN denotes from
T15388 29082-29087 VBN denotes fixed
T15389 29097-29103 NN denotes tissue
T15390 29088-29096 JJ denotes thoracic
T15391 29104-29108 IN denotes from
T15392 29109-29114 NN denotes E15.5
T15393 29125-29132 NNS denotes embryos
T15394 29115-29118 CC denotes and
T15395 29119-29124 NN denotes E17.5
T15396 29132-29133 . denotes .
T15397 29133-29572 sentence denotes For lung explant culture, lungs were dissected from fresh embryos at E11.5 and E12.5 and placed on porous 24-mm (0.4-μ) polyester membranes floated in wells containing 2 ml of Dulbecco's modified Eagle's medium, nutrient mixture F-12 (11039–021, Gibco, San Diego, California, United States), supplemented with 10% fetal bovine serum, 0.3 mg/ml L-glutamine, 100 units/ml penicillin, 100 mcg/ml streptomycin, and 0.25 mcg/ml amphotericin B.
T15398 29134-29137 IN denotes For
T15399 29171-29180 VBN denotes dissected
T15400 29138-29142 NN denotes lung
T15401 29151-29158 NN denotes culture
T15402 29143-29150 NN denotes explant
T15403 29158-29160 , denotes ,
T15404 29160-29165 NNS denotes lungs
T15405 29166-29170 VBD denotes were
T15406 29181-29185 IN denotes from
T15407 29186-29191 JJ denotes fresh
T15408 29192-29199 NNS denotes embryos
T15409 29200-29202 IN denotes at
T15410 29203-29208 NN denotes E11.5
T15411 29209-29212 CC denotes and
T15412 29213-29218 NN denotes E12.5
T15413 29219-29222 CC denotes and
T15414 29223-29229 VBN denotes placed
T15415 29230-29232 IN denotes on
T15416 29233-29239 JJ denotes porous
T15417 29264-29273 NNS denotes membranes
T15418 29240-29242 CD denotes 24
T15419 29243-29245 NN denotes mm
T15420 29242-29243 HYPH denotes -
T15421 29246-29247 -LRB- denotes (
T15422 29251-29252 NN denotes μ
T15423 29247-29250 CD denotes 0.4
T15424 29250-29251 HYPH denotes -
T15425 29252-29253 -RRB- denotes )
T15426 29254-29263 NN denotes polyester
T15427 29274-29281 VBN denotes floated
T15428 29282-29284 IN denotes in
T15429 29285-29290 NNS denotes wells
T15430 29291-29301 VBG denotes containing
T15431 29302-29303 CD denotes 2
T15432 29304-29306 NN denotes ml
T15433 29307-29309 IN denotes of
T15434 29310-29318 NNP denotes Dulbecco
T15435 29338-29344 NN denotes medium
T15436 29318-29320 POS denotes 's
T15437 29321-29329 VBN denotes modified
T15438 29330-29335 NNP denotes Eagle
T15439 29335-29337 POS denotes 's
T15440 29344-29346 , denotes ,
T15441 29346-29354 NN denotes nutrient
T15442 29355-29362 NN denotes mixture
T15443 29363-29364 NN denotes F
T15444 29364-29365 HYPH denotes -
T15445 29365-29367 CD denotes 12
T15446 29368-29369 -LRB- denotes (
T15447 29380-29385 NNP denotes Gibco
T15448 29369-29374 CD denotes 11039
T15449 29375-29378 CD denotes 021
T15450 29374-29375 HYPH denotes –
T15451 29378-29380 , denotes ,
T15452 29385-29387 , denotes ,
T15453 29387-29390 NNP denotes San
T15454 29391-29396 NNP denotes Diego
T15455 29396-29398 , denotes ,
T15456 29398-29408 NNP denotes California
T15457 29408-29410 , denotes ,
T15458 29410-29416 NNP denotes United
T15459 29417-29423 NNP denotes States
T15460 29423-29424 -RRB- denotes )
T15461 29424-29426 , denotes ,
T15462 29426-29438 VBN denotes supplemented
T15463 29439-29443 IN denotes with
T15464 29444-29446 CD denotes 10
T15465 29446-29447 NN denotes %
T15466 29461-29466 NN denotes serum
T15467 29448-29453 JJ denotes fetal
T15468 29454-29460 JJ denotes bovine
T15469 29466-29468 , denotes ,
T15470 29468-29471 CD denotes 0.3
T15471 29472-29474 NN denotes mg
T15472 29480-29489 NN denotes glutamine
T15473 29474-29475 SYM denotes /
T15474 29475-29477 NN denotes ml
T15475 29478-29479 NN denotes L
T15476 29479-29480 HYPH denotes -
T15477 29489-29491 , denotes ,
T15478 29491-29494 CD denotes 100
T15479 29495-29500 NNS denotes units
T15480 29504-29514 NN denotes penicillin
T15481 29500-29501 SYM denotes /
T15482 29501-29503 NN denotes ml
T15483 29514-29516 , denotes ,
T15484 29516-29519 CD denotes 100
T15485 29520-29523 NN denotes mcg
T15486 29527-29539 NN denotes streptomycin
T15487 29523-29524 SYM denotes /
T15488 29524-29526 NN denotes ml
T15489 29539-29541 , denotes ,
T15490 29541-29544 CC denotes and
T15491 29545-29549 CD denotes 0.25
T15492 29550-29553 NN denotes mcg
T15493 29570-29571 NN denotes B
T15494 29553-29554 SYM denotes /
T15495 29554-29556 NN denotes ml
T15496 29557-29569 NN denotes amphotericin
T15497 29571-29572 . denotes .
T15498 29572-29642 sentence denotes Lung explants were cultured at 37 °C in 95% air/5% CO2 for up to 5 d.
T15499 29573-29577 NN denotes Lung
T15500 29578-29586 NNS denotes explants
T15501 29592-29600 VBN denotes cultured
T15502 29587-29591 VBD denotes were
T15503 29601-29603 IN denotes at
T15504 29604-29606 CD denotes 37
T15505 29607-29609 NN denotes °C
T15506 29610-29612 IN denotes in
T15507 29613-29615 CD denotes 95
T15508 29615-29616 NN denotes %
T15509 29617-29620 NN denotes air
T15510 29620-29621 HYPH denotes /
T15511 29621-29622 CD denotes 5
T15512 29622-29623 NN denotes %
T15513 29624-29627 NN denotes CO2
T15514 29628-29631 IN denotes for
T15515 29632-29634 RB denotes up
T15516 29638-29639 CD denotes 5
T15517 29635-29637 IN denotes to
T15518 29640-29641 NN denotes d
T15519 29641-29642 . denotes .
T15520 29642-29778 sentence denotes They were photographed daily with a dissecting microscope (MZ12.5, Leica, Wetzlar, Germany) equipped with a Leica DC500 digital camera.
T15521 29643-29647 PRP denotes They
T15522 29653-29665 VBN denotes photographed
T15523 29648-29652 VBD denotes were
T15524 29666-29671 RB denotes daily
T15525 29672-29676 IN denotes with
T15526 29677-29678 DT denotes a
T15527 29690-29700 NN denotes microscope
T15528 29679-29689 VBG denotes dissecting
T15529 29701-29702 -LRB- denotes (
T15530 29702-29708 NN denotes MZ12.5
T15531 29708-29710 , denotes ,
T15532 29710-29715 NNP denotes Leica
T15533 29715-29717 , denotes ,
T15534 29717-29724 NNP denotes Wetzlar
T15535 29724-29726 , denotes ,
T15536 29726-29733 NNP denotes Germany
T15537 29733-29734 -RRB- denotes )
T15538 29735-29743 VBN denotes equipped
T15539 29744-29748 IN denotes with
T15540 29749-29750 DT denotes a
T15541 29771-29777 NN denotes camera
T15542 29751-29756 NNP denotes Leica
T15543 29757-29762 NN denotes DC500
T15544 29763-29770 JJ denotes digital
T15545 29777-29778 . denotes .
T15546 29778-29881 sentence denotes Transgenic mice carrying the lacZ gene driven by the Fog2 promoter have been developed by S. Tevosian.
T15547 29779-29789 JJ denotes Transgenic
T15548 29790-29794 NNS denotes mice
T15549 29856-29865 VBN denotes developed
T15550 29795-29803 VBG denotes carrying
T15551 29804-29807 DT denotes the
T15552 29813-29817 NN denotes gene
T15553 29808-29812 NN denotes lacZ
T15554 29818-29824 VBN denotes driven
T15555 29825-29827 IN denotes by
T15556 29828-29831 DT denotes the
T15557 29837-29845 NN denotes promoter
T15558 29832-29836 NN denotes Fog2
T15559 29846-29850 VBP denotes have
T15560 29851-29855 VBN denotes been
T15561 29866-29868 IN denotes by
T15562 29869-29871 NNP denotes S.
T15563 29872-29880 NNP denotes Tevosian
T15564 29880-29881 . denotes .
T15565 29881-30081 sentence denotes In these animals, the lacZ gene is incorporated (“knocked-in”) into the Fog2 locus to allow β-galactosidase expression as a fusion protein in frame with the first 235 amino acids of the FOG2 protein.
T15566 29882-29884 IN denotes In
T15567 29917-29929 VBN denotes incorporated
T15568 29885-29890 DT denotes these
T15569 29891-29898 NNS denotes animals
T15570 29898-29900 , denotes ,
T15571 29900-29903 DT denotes the
T15572 29909-29913 NN denotes gene
T15573 29904-29908 NN denotes lacZ
T15574 29914-29916 VBZ denotes is
T15575 29930-29931 -LRB- denotes (
T15576 29932-29939 VBN denotes knocked
T15577 29931-29932 `` denotes “
T15578 29939-29940 HYPH denotes -
T15579 29940-29942 RP denotes in
T15580 29942-29943 '' denotes ”
T15581 29943-29944 -RRB- denotes )
T15582 29945-29949 IN denotes into
T15583 29950-29953 DT denotes the
T15584 29959-29964 NN denotes locus
T15585 29954-29958 NN denotes Fog2
T15586 29965-29967 TO denotes to
T15587 29968-29973 VB denotes allow
T15588 29974-29975 NN denotes β
T15589 29976-29989 NN denotes galactosidase
T15590 29975-29976 HYPH denotes -
T15591 29990-30000 NN denotes expression
T15592 30001-30003 IN denotes as
T15593 30004-30005 DT denotes a
T15594 30013-30020 NN denotes protein
T15595 30006-30012 NN denotes fusion
T15596 30021-30023 IN denotes in
T15597 30024-30029 NN denotes frame
T15598 30030-30034 IN denotes with
T15599 30035-30038 DT denotes the
T15600 30055-30060 NNS denotes acids
T15601 30039-30044 JJ denotes first
T15602 30045-30048 CD denotes 235
T15603 30049-30054 NN denotes amino
T15604 30061-30063 IN denotes of
T15605 30064-30067 DT denotes the
T15606 30073-30080 NN denotes protein
T15607 30068-30072 NN denotes FOG2
T15608 30080-30081 . denotes .
T15609 30081-30140 sentence denotes The Fog2-lacZ module is followed by an ires-eGFP cassette.
T15610 30082-30085 DT denotes The
T15611 30096-30102 NN denotes module
T15612 30086-30090 NN denotes Fog2
T15613 30091-30095 NN denotes lacZ
T15614 30090-30091 HYPH denotes -
T15615 30106-30114 VBN denotes followed
T15616 30103-30105 VBZ denotes is
T15617 30115-30117 IN denotes by
T15618 30118-30120 DT denotes an
T15619 30131-30139 NN denotes cassette
T15620 30121-30125 NN denotes ires
T15621 30126-30130 NN denotes eGFP
T15622 30125-30126 HYPH denotes -
T15623 30139-30140 . denotes .
T15624 30140-30181 sentence denotes This creates a null allele of Fog2 gene.
T15625 30141-30145 DT denotes This
T15626 30146-30153 VBZ denotes creates
T15627 30154-30155 DT denotes a
T15628 30161-30167 NN denotes allele
T15629 30156-30160 JJ denotes null
T15630 30168-30170 IN denotes of
T15631 30171-30175 NN denotes Fog2
T15632 30176-30180 NN denotes gene
T15633 30180-30181 . denotes .
T15634 30181-30277 sentence denotes The Fog2-LacZ-eGFP construct was linearized with KspI and electroporated into the CJ7 ES cells.
T15635 30182-30185 DT denotes The
T15636 30201-30210 NN denotes construct
T15637 30186-30190 NN denotes Fog2
T15638 30196-30200 NN denotes eGFP
T15639 30190-30191 HYPH denotes -
T15640 30191-30195 NN denotes LacZ
T15641 30195-30196 HYPH denotes -
T15642 30215-30225 VBN denotes linearized
T15643 30211-30214 VBD denotes was
T15644 30226-30230 IN denotes with
T15645 30231-30235 NN denotes KspI
T15646 30236-30239 CC denotes and
T15647 30240-30254 VBN denotes electroporated
T15648 30255-30259 IN denotes into
T15649 30260-30263 DT denotes the
T15650 30271-30276 NNS denotes cells
T15651 30264-30267 NN denotes CJ7
T15652 30268-30270 NN denotes ES
T15653 30276-30277 . denotes .
T15654 30277-30389 sentence denotes The correctly targeted clone was selected by the Southern blot analysis and injected into C57BL/6J blastocysts.
T15655 30278-30281 DT denotes The
T15656 30301-30306 NN denotes clone
T15657 30282-30291 RB denotes correctly
T15658 30292-30300 VBN denotes targeted
T15659 30311-30319 VBN denotes selected
T15660 30307-30310 VBD denotes was
T15661 30320-30322 IN denotes by
T15662 30323-30326 DT denotes the
T15663 30341-30349 NN denotes analysis
T15664 30327-30335 NNP denotes Southern
T15665 30336-30340 NN denotes blot
T15666 30350-30353 CC denotes and
T15667 30354-30362 VBN denotes injected
T15668 30363-30367 IN denotes into
T15669 30368-30373 NN denotes C57BL
T15670 30374-30376 NN denotes 6J
T15671 30373-30374 HYPH denotes /
T15672 30377-30388 NNS denotes blastocysts
T15673 30388-30389 . denotes .
T15674 30389-30466 sentence denotes Fog2-lacZ-eGFP animals were maintained on the mixed C57BL/6J/129 background.
T15675 30390-30394 NN denotes Fog2
T15676 30400-30404 NN denotes eGFP
T15677 30394-30395 HYPH denotes -
T15678 30395-30399 NN denotes lacZ
T15679 30399-30400 HYPH denotes -
T15680 30405-30412 NNS denotes animals
T15681 30418-30428 VBN denotes maintained
T15682 30413-30417 VBD denotes were
T15683 30429-30431 IN denotes on
T15684 30432-30435 DT denotes the
T15685 30455-30465 NN denotes background
T15686 30436-30441 JJ denotes mixed
T15687 30442-30447 NN denotes C57BL
T15688 30448-30450 NN denotes 6J
T15689 30447-30448 HYPH denotes /
T15690 30450-30451 HYPH denotes /
T15691 30451-30454 CD denotes 129
T15692 30465-30466 . denotes .
T15693 30466-30609 sentence denotes lacZ Expression in whole dissected embryonic lungs was analyzed by staining for β-galactosidase activity with X-gal after fixation for 30 min.
T15694 30467-30471 NN denotes lacZ
T15695 30472-30482 NN denotes Expression
T15696 30522-30530 VBN denotes analyzed
T15697 30483-30485 IN denotes in
T15698 30486-30491 JJ denotes whole
T15699 30512-30517 NNS denotes lungs
T15700 30492-30501 VBN denotes dissected
T15701 30502-30511 JJ denotes embryonic
T15702 30518-30521 VBD denotes was
T15703 30531-30533 IN denotes by
T15704 30534-30542 VBG denotes staining
T15705 30543-30546 IN denotes for
T15706 30547-30548 NN denotes β
T15707 30549-30562 NN denotes galactosidase
T15708 30548-30549 HYPH denotes -
T15709 30563-30571 NN denotes activity
T15710 30572-30576 IN denotes with
T15711 30577-30578 NN denotes X
T15712 30579-30582 NN denotes gal
T15713 30578-30579 HYPH denotes -
T15714 30583-30588 IN denotes after
T15715 30589-30597 NN denotes fixation
T15716 30598-30601 IN denotes for
T15717 30602-30604 CD denotes 30
T15718 30605-30608 NN denotes min
T15719 30608-30609 . denotes .
T16000 30611-30613 NN denotes RT
T16001 30614-30617 NN denotes PCR
T16002 30613-30614 HYPH denotes -
T16003 30618-30621 CC denotes and
T16004 30622-30630 NN denotes sequence
T16005 30631-30639 NN denotes analysis
T16006 30640-30642 IN denotes in
T16007 30643-30646 DT denotes the
T16008 30647-30652 NN denotes mouse
T16009 30652-30653 . denotes .
T16010 30653-30726 sentence denotes RNA was extracted by standard techniques from thoracic embryonic tissue.
T16011 30654-30657 NN denotes RNA
T16012 30662-30671 VBN denotes extracted
T16013 30658-30661 VBD denotes was
T16014 30672-30674 IN denotes by
T16015 30675-30683 JJ denotes standard
T16016 30684-30694 NNS denotes techniques
T16017 30695-30699 IN denotes from
T16018 30700-30708 JJ denotes thoracic
T16019 30719-30725 NN denotes tissue
T16020 30709-30718 JJ denotes embryonic
T16021 30725-30726 . denotes .
T16022 30726-30802 sentence denotes RT-PCR was performed using six primer sets designed to cover the Fog2 gene.
T16023 30727-30729 NN denotes RT
T16024 30730-30733 NN denotes PCR
T16025 30729-30730 HYPH denotes -
T16026 30738-30747 VBN denotes performed
T16027 30734-30737 VBD denotes was
T16028 30748-30753 VBG denotes using
T16029 30754-30757 CD denotes six
T16030 30765-30769 NNS denotes sets
T16031 30758-30764 NN denotes primer
T16032 30770-30778 VBN denotes designed
T16033 30779-30781 TO denotes to
T16034 30782-30787 VB denotes cover
T16035 30788-30791 DT denotes the
T16036 30797-30801 NN denotes gene
T16037 30792-30796 NN denotes Fog2
T16038 30801-30802 . denotes .
T16039 30802-31001 sentence denotes RT-PCR was repeated with radiolabeled primers to amplify an abnormally spliced region of the gene (Table S1), and the product was run on a denaturing sequencing gel according to standard techniques.
T16040 30803-30805 NN denotes RT
T16041 30806-30809 NN denotes PCR
T16042 30805-30806 HYPH denotes -
T16043 30814-30822 VBN denotes repeated
T16044 30810-30813 VBD denotes was
T16045 30823-30827 IN denotes with
T16046 30828-30840 VBN denotes radiolabeled
T16047 30841-30848 NNS denotes primers
T16048 30849-30851 TO denotes to
T16049 30852-30859 VB denotes amplify
T16050 30860-30862 DT denotes an
T16051 30882-30888 NN denotes region
T16052 30863-30873 RB denotes abnormally
T16053 30874-30881 VBN denotes spliced
T16054 30889-30891 IN denotes of
T16055 30892-30895 DT denotes the
T16056 30896-30900 NN denotes gene
T16057 30901-30902 -LRB- denotes (
T16058 30908-30910 NN denotes S1
T16059 30902-30907 NN denotes Table
T16060 30910-30911 -RRB- denotes )
T16061 30911-30913 , denotes ,
T16062 30913-30916 CC denotes and
T16063 30917-30920 DT denotes the
T16064 30921-30928 NN denotes product
T16065 30933-30936 VBN denotes run
T16066 30929-30932 VBD denotes was
T16067 30937-30939 IN denotes on
T16068 30940-30941 DT denotes a
T16069 30964-30967 NN denotes gel
T16070 30942-30952 VBG denotes denaturing
T16071 30953-30963 NN denotes sequencing
T16072 30968-30977 VBG denotes according
T16073 30978-30980 IN denotes to
T16074 30981-30989 JJ denotes standard
T16075 30990-31000 NNS denotes techniques
T16076 31000-31001 . denotes .
T16077 31001-31169 sentence denotes The RT-PCR product was cloned into pCR2.1 vector using TOPO TA Cloning Kit (Invitrogen, Carlsbad, California, United States) and sequenced using gene-specific primers.
T16078 31002-31005 DT denotes The
T16079 31013-31020 NN denotes product
T16080 31006-31008 NN denotes RT
T16081 31009-31012 NN denotes PCR
T16082 31008-31009 HYPH denotes -
T16083 31025-31031 VBN denotes cloned
T16084 31021-31024 VBD denotes was
T16085 31032-31036 IN denotes into
T16086 31037-31043 NN denotes pCR2.1
T16087 31044-31050 NN denotes vector
T16088 31051-31056 VBG denotes using
T16089 31057-31061 NN denotes TOPO
T16090 31073-31076 NNP denotes Kit
T16091 31062-31064 NN denotes TA
T16092 31065-31072 NNP denotes Cloning
T16093 31077-31078 -LRB- denotes (
T16094 31078-31088 NNP denotes Invitrogen
T16095 31088-31090 , denotes ,
T16096 31090-31098 NNP denotes Carlsbad
T16097 31098-31100 , denotes ,
T16098 31100-31110 NNP denotes California
T16099 31110-31112 , denotes ,
T16100 31112-31118 NNP denotes United
T16101 31119-31125 NNP denotes States
T16102 31125-31126 -RRB- denotes )
T16103 31127-31130 CC denotes and
T16104 31131-31140 VBN denotes sequenced
T16105 31141-31146 VBG denotes using
T16106 31147-31151 NN denotes gene
T16107 31152-31160 JJ denotes specific
T16108 31151-31152 HYPH denotes -
T16109 31161-31168 NNS denotes primers
T16110 31168-31169 . denotes .
T16111 31169-31267 sentence denotes Sequence analysis was done using Sequencher 4.1 (Gene Codes, Ann Arbor, Michigan, United States).
T16112 31170-31178 NN denotes Sequence
T16113 31179-31187 NN denotes analysis
T16114 31192-31196 VBN denotes done
T16115 31188-31191 VBD denotes was
T16116 31197-31202 VBG denotes using
T16117 31203-31213 NNP denotes Sequencher
T16118 31214-31217 CD denotes 4.1
T16119 31218-31219 -LRB- denotes (
T16120 31224-31229 NNPS denotes Codes
T16121 31219-31223 NNP denotes Gene
T16122 31229-31231 , denotes ,
T16123 31231-31234 NNP denotes Ann
T16124 31235-31240 NNP denotes Arbor
T16125 31240-31242 , denotes ,
T16126 31242-31250 NNP denotes Michigan
T16127 31250-31252 , denotes ,
T16128 31252-31258 NNP denotes United
T16129 31259-31265 NNP denotes States
T16130 31265-31266 -RRB- denotes )
T16131 31266-31267 . denotes .
T16289 31269-31271 FW denotes In
T16290 31272-31276 FW denotes situ
T16291 31277-31290 NN denotes hybridization
T16292 31290-31291 . denotes .
T16293 31291-31425 sentence denotes After dehydration and embedding in paraffin wax, 10-μ sections were subjected to radioactive in situ hybridization as described [53].
T16294 31292-31297 IN denotes After
T16295 31360-31369 VBN denotes subjected
T16296 31298-31309 NN denotes dehydration
T16297 31310-31313 CC denotes and
T16298 31314-31323 NN denotes embedding
T16299 31324-31326 IN denotes in
T16300 31327-31335 NN denotes paraffin
T16301 31336-31339 NN denotes wax
T16302 31339-31341 , denotes ,
T16303 31341-31343 CD denotes 10
T16304 31344-31345 NN denotes μ
T16305 31343-31344 HYPH denotes -
T16306 31346-31354 NNS denotes sections
T16307 31355-31359 VBD denotes were
T16308 31370-31372 IN denotes to
T16309 31373-31384 JJ denotes radioactive
T16310 31393-31406 NN denotes hybridization
T16311 31385-31387 FW denotes in
T16312 31388-31392 FW denotes situ
T16313 31407-31409 IN denotes as
T16314 31410-31419 VBN denotes described
T16315 31420-31421 -LRB- denotes [
T16316 31421-31423 CD denotes 53
T16317 31423-31424 -RRB- denotes ]
T16318 31424-31425 . denotes .
T16319 31425-31555 sentence denotes Probes labeled with 35S were prepared by run-off transcription of linearized plasmid templates and hybridized to tissue sections.
T16320 31426-31432 NNS denotes Probes
T16321 31455-31463 VBN denotes prepared
T16322 31433-31440 VBN denotes labeled
T16323 31441-31445 IN denotes with
T16324 31446-31449 NN denotes 35S
T16325 31450-31454 VBD denotes were
T16326 31464-31466 IN denotes by
T16327 31467-31470 VB denotes run
T16328 31475-31488 NN denotes transcription
T16329 31470-31471 HYPH denotes -
T16330 31471-31474 RP denotes off
T16331 31489-31491 IN denotes of
T16332 31492-31502 VBN denotes linearized
T16333 31511-31520 NNS denotes templates
T16334 31503-31510 NN denotes plasmid
T16335 31521-31524 CC denotes and
T16336 31525-31535 VBN denotes hybridized
T16337 31536-31538 IN denotes to
T16338 31539-31545 NN denotes tissue
T16339 31546-31554 NNS denotes sections
T16340 31554-31555 . denotes .
T16341 31555-31668 sentence denotes Nuclei were counterstained with Hoescht 33258, and signal was imaged using fluorescent and darkfield microscopy.
T16342 31556-31562 NNS denotes Nuclei
T16343 31568-31582 VBN denotes counterstained
T16344 31563-31567 VBD denotes were
T16345 31583-31587 IN denotes with
T16346 31588-31595 NNP denotes Hoescht
T16347 31596-31601 CD denotes 33258
T16348 31601-31603 , denotes ,
T16349 31603-31606 CC denotes and
T16350 31607-31613 NN denotes signal
T16351 31618-31624 VBN denotes imaged
T16352 31614-31617 VBD denotes was
T16353 31625-31630 VBG denotes using
T16354 31631-31642 JJ denotes fluorescent
T16355 31657-31667 NN denotes microscopy
T16356 31643-31646 CC denotes and
T16357 31647-31656 NN denotes darkfield
T16358 31667-31668 . denotes .
T16688 31670-31675 JJ denotes Human
T16689 31680-31690 NN denotes extraction
T16690 31676-31679 NN denotes DNA
T16691 31691-31694 CC denotes and
T16692 31695-31703 NN denotes sequence
T16693 31704-31712 NN denotes analysis
T16694 31712-31713 . denotes .
T16695 31713-31840 sentence denotes DNA was isolated from paraffin blocks by phenol-chloroform extraction [54,55], and from frozen tissues by standard techniques.
T16696 31714-31717 NN denotes DNA
T16697 31722-31730 VBN denotes isolated
T16698 31718-31721 VBD denotes was
T16699 31731-31735 IN denotes from
T16700 31736-31744 NN denotes paraffin
T16701 31745-31751 NNS denotes blocks
T16702 31752-31754 IN denotes by
T16703 31755-31761 NN denotes phenol
T16704 31762-31772 NN denotes chloroform
T16705 31761-31762 HYPH denotes -
T16706 31773-31783 NN denotes extraction
T16707 31784-31785 -LRB- denotes [
T16708 31788-31790 CD denotes 55
T16709 31785-31787 CD denotes 54
T16710 31787-31788 , denotes ,
T16711 31790-31791 -RRB- denotes ]
T16712 31791-31793 , denotes ,
T16713 31793-31796 CC denotes and
T16714 31797-31801 IN denotes from
T16715 31802-31808 VBN denotes frozen
T16716 31809-31816 NNS denotes tissues
T16717 31817-31819 IN denotes by
T16718 31820-31828 JJ denotes standard
T16719 31829-31839 NNS denotes techniques
T16720 31839-31840 . denotes .
T16721 31840-31948 sentence denotes Primers were designed to amplify FOG2 coding exons plus 50 bp of flanking upstream and downstream sequence.
T16722 31841-31848 NNS denotes Primers
T16723 31854-31862 VBN denotes designed
T16724 31849-31853 VBD denotes were
T16725 31863-31865 TO denotes to
T16726 31866-31873 VB denotes amplify
T16727 31874-31878 NN denotes FOG2
T16728 31886-31891 NNS denotes exons
T16729 31879-31885 NN denotes coding
T16730 31892-31896 CC denotes plus
T16731 31897-31899 CD denotes 50
T16732 31900-31902 NN denotes bp
T16733 31903-31905 IN denotes of
T16734 31906-31914 VBG denotes flanking
T16735 31939-31947 NN denotes sequence
T16736 31915-31923 JJ denotes upstream
T16737 31924-31927 CC denotes and
T16738 31928-31938 JJ denotes downstream
T16739 31947-31948 . denotes .
T16740 31948-32017 sentence denotes PCR amplification and sequencing were performed by standard methods.
T16741 31949-31952 NN denotes PCR
T16742 31953-31966 NN denotes amplification
T16743 31987-31996 VBN denotes performed
T16744 31967-31970 CC denotes and
T16745 31971-31981 NN denotes sequencing
T16746 31982-31986 VBD denotes were
T16747 31997-31999 IN denotes by
T16748 32000-32008 JJ denotes standard
T16749 32009-32016 NNS denotes methods
T16750 32016-32017 . denotes .
T16751 32017-32063 sentence denotes Primer sequences used are listed in Table S2.
T16752 32018-32024 NN denotes Primer
T16753 32025-32034 NNS denotes sequences
T16754 32044-32050 VBN denotes listed
T16755 32035-32039 VBN denotes used
T16756 32040-32043 VBP denotes are
T16757 32051-32053 IN denotes in
T16758 32054-32059 NN denotes Table
T16759 32060-32062 NN denotes S2
T16760 32062-32063 . denotes .
T16761 32063-32124 sentence denotes Sequence analysis was done with Sequencher 4.1 (Gene Codes).
T16762 32064-32072 NN denotes Sequence
T16763 32073-32081 NN denotes analysis
T16764 32086-32090 VBN denotes done
T16765 32082-32085 VBD denotes was
T16766 32091-32095 IN denotes with
T16767 32096-32106 NNP denotes Sequencher
T16768 32107-32110 CD denotes 4.1
T16769 32111-32112 -LRB- denotes (
T16770 32117-32122 NNPS denotes Codes
T16771 32112-32116 NNP denotes Gene
T16772 32122-32123 -RRB- denotes )
T16773 32123-32124 . denotes .
T16774 32124-32208 sentence denotes DNA from the parents of one autopsy patient was extracted from fresh blood samples.
T16775 32125-32128 NN denotes DNA
T16776 32173-32182 VBN denotes extracted
T16777 32129-32133 IN denotes from
T16778 32134-32137 DT denotes the
T16779 32138-32145 NNS denotes parents
T16780 32146-32148 IN denotes of
T16781 32149-32152 CD denotes one
T16782 32161-32168 NN denotes patient
T16783 32153-32160 NN denotes autopsy
T16784 32169-32172 VBD denotes was
T16785 32183-32187 IN denotes from
T16786 32188-32193 JJ denotes fresh
T16787 32200-32207 NNS denotes samples
T16788 32194-32199 NN denotes blood
T16789 32207-32208 . denotes .
T16790 32208-32338 sentence denotes A second set of blood samples was sent to an outside CLIA-certified laboratory for DNA extraction, PCR, sequencing, and analysis.
T16791 32209-32210 DT denotes A
T16792 32218-32221 NN denotes set
T16793 32211-32217 JJ denotes second
T16794 32243-32247 VBN denotes sent
T16795 32222-32224 IN denotes of
T16796 32225-32230 NN denotes blood
T16797 32231-32238 NNS denotes samples
T16798 32239-32242 VBD denotes was
T16799 32248-32250 IN denotes to
T16800 32251-32253 DT denotes an
T16801 32277-32287 NN denotes laboratory
T16802 32254-32261 JJ denotes outside
T16803 32262-32266 NN denotes CLIA
T16804 32267-32276 VBN denotes certified
T16805 32266-32267 HYPH denotes -
T16806 32288-32291 IN denotes for
T16807 32292-32295 NN denotes DNA
T16808 32296-32306 NN denotes extraction
T16809 32306-32308 , denotes ,
T16810 32308-32311 NN denotes PCR
T16811 32311-32313 , denotes ,
T16812 32313-32323 NN denotes sequencing
T16813 32323-32325 , denotes ,
T16814 32325-32328 CC denotes and
T16815 32329-32337 NN denotes analysis
T16816 32337-32338 . denotes .
T16817 32338-32431 sentence denotes Paternity testing was performed by the outside laboratory using a standard panel of markers.
T16818 32339-32348 NN denotes Paternity
T16819 32349-32356 NN denotes testing
T16820 32361-32370 VBN denotes performed
T16821 32357-32360 VBD denotes was
T16822 32371-32373 IN denotes by
T16823 32374-32377 DT denotes the
T16824 32386-32396 NN denotes laboratory
T16825 32378-32385 JJ denotes outside
T16826 32397-32402 VBG denotes using
T16827 32403-32404 DT denotes a
T16828 32414-32419 NN denotes panel
T16829 32405-32413 JJ denotes standard
T16830 32420-32422 IN denotes of
T16831 32423-32430 NNS denotes markers
T16832 32430-32431 . denotes .
T16833 32431-32579 sentence denotes SNP genotyping was done using Harvard Partners Center for Genetics and Genomics genotyping core facility (Cambridge, Massachusetts, United States).
T16834 32432-32435 NN denotes SNP
T16835 32436-32446 NN denotes genotyping
T16836 32451-32455 VBN denotes done
T16837 32447-32450 VBD denotes was
T16838 32456-32461 VBG denotes using
T16839 32462-32469 NNP denotes Harvard
T16840 32479-32485 NNP denotes Center
T16841 32470-32478 NNPS denotes Partners
T16842 32528-32536 NN denotes facility
T16843 32486-32489 IN denotes for
T16844 32490-32498 NNP denotes Genetics
T16845 32499-32502 CC denotes and
T16846 32503-32511 NNP denotes Genomics
T16847 32512-32522 NN denotes genotyping
T16848 32523-32527 NN denotes core
T16849 32537-32538 -LRB- denotes (
T16850 32538-32547 NNP denotes Cambridge
T16851 32547-32549 , denotes ,
T16852 32549-32562 NNP denotes Massachusetts
T16853 32562-32564 , denotes ,
T16854 32564-32570 NNP denotes United
T16855 32571-32577 NNP denotes States
T16856 32577-32578 -RRB- denotes )
T16857 32578-32579 . denotes .
T1018 212-215 VBP denotes are
R3 T1001 T1000 auxpass Is,Required
R4 T1002 T1000 prep for,Required
R5 T1003 T1004 amod Normal,Development
R6 T1004 T1002 pobj Development,for
R7 T1005 T1004 nmod Diaphragm,Development
R8 T1006 T1005 cc and,Diaphragm
R9 T1007 T1005 conj Lung,Diaphragm
R10 T1008 T1000 prep in,Required
R11 T1009 T1008 pobj Mice,in
R12 T1010 T1009 cc and,Mice
R13 T1011 T1009 conj Humans,Mice
R14 T1015 T1016 amod Congenital,hernia
R16 T1017 T1016 amod diaphragmatic,hernia
R17 T1019 T1016 cc and,hernia
R18 T1020 T1021 amod other,defects
R19 T1021 T1016 conj defects,hernia
R20 T1022 T1021 amod congenital,defects
R21 T1023 T1021 amod diaphragmatic,defects
R34 T1037 T1024 nsubj basis,is
R35 T1038 T1037 amod molecular,basis
R38 T1041 T1039 pobj anomalies,of
R39 T1042 T1041 amod developmental,anomalies
R54 T1059 T1057 pobj ethyl,with
R55 T1060 T1059 punct -,ethyl
R58 T1063 T1059 appos nitrosourea,ethyl
R59 T1064 T1063 punct -,nitrosourea
R70 T1075 T1072 conj development,hypoplasia
R71 T1076 T1075 amod diaphragmatic,development
R79 T1086 T1084 pobj interval,within
R80 T1087 T1086 amod recombinant,interval
R83 T1090 T1088 dobj mutation,carrying
R84 T1091 T1092 compound N,ethyl
R86 T1093 T1092 punct -,ethyl
R87 T1094 T1090 amod induced,mutation
R88 T1095 T1092 punct -,ethyl
R89 T1096 T1097 compound N,nitrosourea
R90 T1097 T1092 appos nitrosourea,ethyl
R91 T1098 T1097 punct -,nitrosourea
R92 T1099 T1094 punct -,induced
R97 T1104 T1080 conj identified,maps
R98 T1105 T1103 prep of,sequencing
R99 T1106 T1105 pobj Fog2,of
R104 T1111 T1109 pobj site,in
R105 T1112 T1111 compound splice,site
R106 T1113 T1111 compound donor,site
R110 T1117 T1115 dobj transcript,generates
R111 T1118 T1117 amod abnormal,transcript
R114 T1121 T1119 dobj protein,encoding
R115 T1122 T1121 amod truncated,protein
R118 T1126 T1128 nsubjpass cases,evaluated
R119 T1127 T1126 compound autopsy,cases
R135 T1146 T1144 dobj mutation,revealed
R136 T1147 T1148 advmod de,novo
R137 T1148 T1146 amod novo,mutation
R141 T1152 T1150 pobj codon,in
R142 T1153 T1152 amod premature,codon
R143 T1154 T1152 compound stop,codon
R151 T1162 T1160 pobj day,on
R152 T1163 T1162 amod first,day
R158 T1169 T1167 pobj hypoplasia,to
R159 T1170 T1169 amod bilateral,hypoplasia
R160 T1171 T1169 amod pulmonary,hypoplasia
R163 T1174 T1169 conj diaphragm,hypoplasia
R164 T1175 T1176 advmod abnormally,muscularized
R165 T1176 T1174 amod muscularized,diaphragm
R169 T1182 T1179 dobj approach,Using
R170 T1183 T1184 npadvmod phenotype,driven
R172 T1185 T1184 punct -,driven
R177 T1190 T1180 ccomp required,established
R178 T1191 T1190 nsubjpass Fog2,required
R179 T1192 T1190 auxpass is,required
R182 T1195 T1193 pobj development,for
R183 T1196 T1195 nmod diaphragm,development
R184 T1197 T1196 cc and,diaphragm
R185 T1198 T1196 conj lung,diaphragm
R190 T1203 T1201 relcl appreciated,role
R191 T1204 T1203 aux has,appreciated
R192 T1205 T1203 neg not,appreciated
R193 T1206 T1203 auxpass been,appreciated
R194 T1207 T1203 advmod previously,appreciated
R198 T1213 T1211 attr gene,is
R199 T1214 T1213 amod first,gene
R206 T1221 T1219 pobj defects,of
R207 T1222 T1221 amod human,defects
R208 T1223 T1221 amod congenital,defects
R209 T1224 T1221 amod diaphragmatic,defects
R214 T1229 T1211 conj validates,is
R215 T1230 T1228 prep for,necessity
R216 T1231 T1232 amod pulmonary,development
R217 T1232 T1230 pobj development,for
R221 T1236 T1234 acl have,hypothesis
R222 T1237 T1236 nsubj neonates,have
R223 T1238 T1237 prep with,neonates
R224 T1239 T1240 amod congenital,hernia
R226 T1241 T1240 amod diaphragmatic,hernia
R227 T1242 T1236 aux may,have
R228 T1243 T1236 advmod also,have
R230 T1245 T1236 dobj abnormalities,have
R231 T1246 T1245 amod pulmonary,abnormalities
R232 T1247 T1245 amod developmental,abnormalities
R234 T1018 T1024 ccomp are,is
R237 T2580 T2581 amod Congenital,defects
R238 T2581 T2583 nsubj defects,are
R239 T2582 T2581 amod diaphragmatic,defects
R240 T2584 T2585 det a,spectrum
R241 T2585 T2583 attr spectrum,are
R242 T2586 T2585 prep of,spectrum
R243 T2587 T2588 advmod relatively,common
R244 T2588 T2589 amod common,defects
R245 T2589 T2586 pobj defects,of
R246 T2590 T2589 compound birth,defects
R247 T2591 T2583 punct .,are
R248 T2593 T2594 det The,Bochdalek
R249 T2594 T2595 nsubj Bochdalek,occur
R250 T2596 T2594 cc or,Bochdalek
R251 T2597 T2598 amod posterolateral,hernias
R252 T2598 T2594 conj hernias,Bochdalek
R253 T2599 T2594 punct (,Bochdalek
R254 T2600 T2601 advmod often,referred
R255 T2601 T2594 acl referred,Bochdalek
R256 T2602 T2601 prep to,referred
R257 T2603 T2601 prep as,referred
R258 T2604 T2605 amod congenital,hernia
R259 T2605 T2603 pobj hernia,as
R260 T2606 T2605 amod diaphragmatic,hernia
R261 T2607 T2605 punct [,hernia
R262 T2608 T2605 appos CDH,hernia
R263 T2609 T2594 punct ],Bochdalek
R264 T2610 T2594 punct ),Bochdalek
R265 T2611 T2595 prep in,occur
R266 T2612 T2613 quantmod 1,"3,000"
R267 T2613 T2615 nummod "3,000",births
R268 T2614 T2613 punct /,"3,000"
R269 T2615 T2611 pobj births,in
R270 T2616 T2615 amod live,births
R271 T2617 T2618 punct [,1
R272 T2618 T2595 parataxis 1,occur
R273 T2619 T2618 punct ],1
R274 T2620 T2595 punct ", ",occur
R275 T2621 T2595 cc and,occur
R276 T2622 T2623 mark although,are
R277 T2623 T2625 advcl are,have
R278 T2624 T2623 nsubj these,are
R279 T2625 T2595 conj have,occur
R280 T2626 T2627 det the,type
R281 T2627 T2623 attr type,are
R282 T2628 T2629 advmod most,common
R283 T2629 T2627 amod common,type
R284 T2630 T2627 prep of,type
R285 T2631 T2632 amod diaphragmatic,defect
R286 T2632 T2630 pobj defect,of
R287 T2633 T2627 acl presenting,type
R288 T2634 T2633 prep at,presenting
R289 T2635 T2634 pobj birth,at
R290 T2636 T2625 punct ", ",have
R291 T2637 T2638 amod diaphragmatic,aplasia
R292 T2638 T2625 nsubj aplasia,have
R293 T2639 T2638 cc and,aplasia
R294 T2640 T2641 amod diaphragmatic,defects
R295 T2641 T2638 conj defects,aplasia
R296 T2642 T2641 compound muscularization,defects
R297 T2643 T2644 punct (,eventrations
R298 T2644 T2641 parataxis eventrations,defects
R299 T2645 T2644 punct ),eventrations
R300 T2646 T2625 aux may,have
R301 T2647 T2648 det a,presentation
R302 T2648 T2625 dobj presentation,have
R303 T2649 T2648 amod similar,presentation
R304 T2650 T2648 amod clinical,presentation
R305 T2651 T2625 punct .,have
R306 T2653 T2654 csubj Making,be
R307 T2655 T2656 amod specific,distinctions
R308 T2656 T2653 dobj distinctions,Making
R309 T2657 T2656 amod anatomic,distinctions
R310 T2658 T2653 prep among,Making
R311 T2659 T2660 det these,types
R312 T2660 T2658 pobj types,among
R313 T2661 T2660 prep of,types
R314 T2662 T2661 pobj defects,of
R315 T2663 T2654 aux can,be
R316 T2664 T2654 acomp difficult,be
R317 T2665 T2654 prep without,be
R318 T2666 T2667 amod direct,examination
R319 T2667 T2665 pobj examination,without
R320 T2668 T2667 amod gross,examination
R321 T2669 T2667 punct (,examination
R322 T2670 T2667 amod intraoperative,examination
R323 T2671 T2670 cc or,intraoperative
R324 T2672 T2670 conj postmortem,intraoperative
R325 T2673 T2667 punct ),examination
R326 T2674 T2654 punct .,be
R327 T2676 T2677 amod Pulmonary,hypoplasia
R328 T2677 T2678 nsubj hypoplasia,causes
R329 T2679 T2677 amod associated,hypoplasia
R330 T2680 T2679 prep with,associated
R331 T2681 T2682 det these,defects
R332 T2682 T2680 pobj defects,with
R333 T2683 T2682 amod diaphragmatic,defects
R334 T2684 T2685 amod severe,mortality
R335 T2685 T2678 dobj mortality,causes
R336 T2686 T2685 cc and,mortality
R337 T2687 T2685 conj morbidity,mortality
R338 T2688 T2678 punct .,causes
R339 T2690 T2691 det The,pathogenesis
R340 T2691 T2692 nsubjpass pathogenesis,understood
R341 T2693 T2691 cc and,pathogenesis
R342 T2694 T2695 amod developmental,relationship
R343 T2695 T2691 conj relationship,pathogenesis
R344 T2696 T2695 prep between,relationship
R345 T2697 T2698 amod diaphragmatic,defects
R346 T2698 T2696 pobj defects,between
R347 T2699 T2698 cc and,defects
R348 T2700 T2701 amod pulmonary,hypoplasia
R349 T2701 T2698 conj hypoplasia,defects
R350 T2702 T2692 auxpass is,understood
R351 T2703 T2692 neg not,understood
R352 T2704 T2692 punct .,understood
R353 T2706 T2707 mark Although,decreased
R354 T2707 T2718 advcl decreased,reported
R355 T2708 T2707 nsubj advances,decreased
R356 T2709 T2708 prep in,advances
R357 T2710 T2711 det the,management
R358 T2711 T2709 pobj management,in
R359 T2712 T2711 amod medical,management
R360 T2713 T2711 prep of,management
R361 T2714 T2715 amod pulmonary,hypoplasia
R362 T2715 T2713 pobj hypoplasia,of
R363 T2716 T2707 aux may,decreased
R364 T2717 T2707 aux have,decreased
R365 T2719 T2720 det the,mortality
R366 T2720 T2707 dobj mortality,decreased
R367 T2721 T2720 amod associated,mortality
R368 T2722 T2721 prep with,associated
R369 T2723 T2724 compound CDH,patients
R370 T2724 T2722 pobj patients,with
R371 T2725 T2726 dep who,survive
R372 T2726 T2724 relcl survive,patients
R373 T2727 T2728 aux to,receive
R374 T2728 T2726 advcl receive,survive
R375 T2729 T2728 dobj care,receive
R376 T2730 T2728 prep at,receive
R377 T2731 T2732 amod high,volume
R378 T2732 T2734 compound volume,centers
R379 T2733 T2732 punct -,volume
R380 T2734 T2730 pobj centers,at
R381 T2735 T2736 punct [,3
R382 T2736 T2707 parataxis 3,decreased
R383 T2737 T2736 nummod 2,3
R384 T2738 T2736 punct ",",3
R385 T2739 T2736 punct ],3
R386 T2740 T2718 punct ", ",reported
R387 T2741 T2742 det the,mortality
R388 T2742 T2718 nsubjpass mortality,reported
R389 T2743 T2744 npadvmod population,based
R390 T2744 T2742 amod based,mortality
R391 T2745 T2744 punct -,based
R392 T2746 T2718 aux has,reported
R393 T2747 T2718 auxpass been,reported
R394 T2748 T2749 aux to,be
R395 T2749 T2718 xcomp be,reported
R396 T2750 T2751 advmod as,62
R397 T2751 T2754 nummod 62,%
R398 T2752 T2751 amod great,62
R399 T2753 T2751 quantmod as,62
R400 T2754 T2749 attr %,be
R401 T2755 T2718 punct ", ",reported
R402 T2756 T2718 cc and,reported
R403 T2757 T2758 expl there,are
R404 T2758 T2718 conj are,reported
R405 T2759 T2760 det a,number
R406 T2760 T2758 attr number,are
R407 T2761 T2760 amod large,number
R408 T2762 T2760 prep of,number
R409 T2763 T2762 pobj deaths,of
R410 T2764 T2765 amod prior,to
R411 T2765 T2758 prep to,are
R412 T2766 T2765 pobj birth,to
R413 T2767 T2765 cc or,to
R414 T2768 T2765 conj to,to
R415 T2769 T2768 pobj transfer,to
R416 T2770 T2769 prep to,transfer
R417 T2771 T2772 det a,facility
R418 T2772 T2770 pobj facility,to
R419 T2773 T2774 amod tertiary,care
R420 T2774 T2772 compound care,facility
R421 T2775 T2776 punct [,4
R422 T2776 T2758 parataxis 4,are
R423 T2777 T2776 punct ],4
R424 T2778 T2718 punct .,reported
R425 T2780 T2781 mark As,present
R426 T2781 T2785 advcl present,centered
R427 T2782 T2783 det these,patients
R428 T2783 T2781 nsubj patients,present
R429 T2784 T2781 advmod commonly,present
R430 T2786 T2781 prep with,present
R431 T2787 T2788 amod severe,failure
R432 T2788 T2786 pobj failure,with
R433 T2789 T2788 amod respiratory,failure
R434 T2790 T2781 prep at,present
R435 T2791 T2790 pobj birth,at
R436 T2792 T2785 punct ", ",centered
R437 T2793 T2785 nsubjpass therapy,centered
R438 T2794 T2785 aux has,centered
R439 T2795 T2785 auxpass been,centered
R440 T2796 T2785 prep around,centered
R441 T2797 T2796 pcomp developing,around
R442 T2798 T2799 amod better,methods
R443 T2799 T2797 dobj methods,developing
R444 T2800 T2801 aux to,provide
R445 T2801 T2799 advcl provide,methods
R446 T2802 T2803 amod ventilatory,support
R447 T2803 T2801 dobj support,provide
R448 T2804 T2805 mark while,producing
R449 T2805 T2801 advcl producing,provide
R450 T2806 T2805 neg not,producing
R451 T2807 T2808 amod further,injury
R452 T2808 T2805 dobj injury,producing
R453 T2809 T2808 compound lung,injury
R454 T2810 T2785 punct .,centered
R455 T2812 T2813 amod Extracorporeal,oxygenation
R456 T2813 T2815 nsubjpass oxygenation,used
R457 T2814 T2813 compound membrane,oxygenation
R458 T2816 T2813 punct (,oxygenation
R459 T2817 T2813 appos ECMO,oxygenation
R460 T2818 T2813 punct ),oxygenation
R461 T2819 T2815 auxpass is,used
R462 T2820 T2815 prep in,used
R463 T2821 T2822 det some,centers
R464 T2822 T2820 pobj centers,in
R465 T2823 T2824 aux to,provide
R466 T2824 T2815 advcl provide,used
R467 T2825 T2826 det an,period
R468 T2826 T2824 dobj period,provide
R469 T2827 T2826 amod extended,period
R470 T2828 T2826 prep of,period
R471 T2829 T2830 amod cardiopulmonary,bypass
R472 T2830 T2828 pobj bypass,of
R473 T2831 T2832 punct [,6
R474 T2832 T2815 parataxis 6,used
R475 T2833 T2832 nummod 5,6
R476 T2834 T2832 punct ",",6
R477 T2835 T2832 punct ],6
R478 T2836 T2815 punct ", ",used
R479 T2837 T2838 mark while,have
R480 T2838 T2815 advcl have,used
R481 T2839 T2840 amod other,centers
R482 T2840 T2838 nsubj centers,have
R483 T2841 T2838 dobj success,have
R484 T2842 T2838 advcl using,have
R485 T2843 T2844 amod other,techniques
R486 T2844 T2842 dobj techniques,using
R487 T2845 T2846 amod ventilatory,support
R488 T2846 T2844 compound support,techniques
R489 T2847 T2848 punct [,7
R490 T2848 T2838 parataxis 7,have
R491 T2849 T2848 punct ],7
R492 T2850 T2815 punct .,used
R493 T2852 T2853 det The,morbidity
R494 T2853 T2854 nsubj morbidity,is
R495 T2855 T2853 prep in,morbidity
R496 T2856 T2855 pobj those,in
R497 T2857 T2858 dep who,survive
R498 T2858 T2856 relcl survive,those
R499 T2859 T2854 acomp high,is
R500 T2860 T2854 punct ", ",is
R501 T2861 T2854 cc and,is
R502 T2862 T2863 amod many,patients
R503 T2863 T2864 nsubj patients,survive
R504 T2864 T2854 conj survive,is
R505 T2865 T2864 prep with,survive
R506 T2866 T2867 amod chronic,insufficiency
R507 T2867 T2865 pobj insufficiency,with
R508 T2868 T2867 amod respiratory,insufficiency
R509 T2869 T2867 punct ", ",insufficiency
R510 T2870 T2871 amod cognitive,deficits
R511 T2871 T2867 conj deficits,insufficiency
R512 T2872 T2870 cc and,cognitive
R513 T2873 T2870 conj neuromotor,cognitive
R514 T2874 T2871 punct ", ",deficits
R515 T2875 T2871 cc and,deficits
R516 T2876 T2877 compound hearing,loss
R517 T2877 T2871 conj loss,deficits
R518 T2878 T2864 prep as,survive
R519 T2879 T2880 det a,result
R520 T2880 T2878 pobj result,as
R521 T2881 T2880 prep of,result
R522 T2882 T2883 amod necessary,interventions
R523 T2883 T2881 pobj interventions,of
R524 T2884 T2883 amod intensive,interventions
R525 T2885 T2883 cc and,interventions
R526 T2886 T2887 amod associated,abnormalities
R527 T2887 T2883 conj abnormalities,interventions
R528 T2888 T2887 amod structural,abnormalities
R529 T2889 T2888 cc and,structural
R530 T2890 T2888 conj irreversible,structural
R531 T2891 T2887 amod developmental,abnormalities
R532 T2892 T2893 punct [,8
R533 T2893 T2864 parataxis 8,survive
R534 T2894 T2895 punct –,11
R535 T2895 T2893 prep 11,8
R536 T2896 T2893 punct ],8
R537 T2897 T2864 punct .,survive
R538 T2899 T2900 prep To,been
R539 T2901 T2899 pobj date,To
R540 T2902 T2900 punct ", ",been
R541 T2903 T2900 expl there,been
R542 T2904 T2900 aux have,been
R543 T2905 T2906 det no,mutations
R544 T2906 T2900 attr mutations,been
R545 T2907 T2906 amod specific,mutations
R546 T2908 T2906 acl found,mutations
R547 T3015 T2998 xcomp develop,is
R548 T3016 T3017 compound animal,models
R549 T3017 T3015 dobj models,develop
R550 T3018 T3017 prep of,models
R551 T3019 T3020 amod human,defects
R552 T3020 T3018 pobj defects,of
R553 T3021 T3020 compound birth,defects
R554 T3022 T3015 punct ", ",develop
R555 T3023 T3024 mark as,investigated
R556 T3024 T3015 advcl investigated,develop
R557 T3025 T3026 det the,abnormalities
R558 T3026 T3024 nsubjpass abnormalities,investigated
R559 T2909 T2910 aux to,be
R560 T3027 T3026 amod specific,abnormalities
R561 T2910 T2908 xcomp be,found
R562 T3028 T3026 amod genetic,abnormalities
R563 T2911 T2910 acomp associated,be
R564 T2912 T2911 prep with,associated
R565 T3029 T3026 acl found,abnormalities
R566 T2913 T2914 amod nonsyndromic,defects
R567 T2914 T2912 pobj defects,with
R568 T2915 T2914 amod diaphragmatic,defects
R569 T3030 T3029 prep in,found
R570 T2916 T2914 cc and,defects
R571 T2917 T2918 amod pulmonary,hypoplasia
R572 T3031 T3032 compound animal,models
R573 T2918 T2914 conj hypoplasia,defects
R574 T2919 T2910 prep in,be
R575 T2920 T2919 pobj humans,in
R576 T3032 T3030 pobj models,in
R577 T2921 T2900 punct .,been
R578 T3033 T3024 aux can,investigated
R579 T2923 T2924 det The,heritability
R580 T2924 T2925 nsubj heritability,is
R581 T3034 T3024 advmod then,investigated
R582 T2926 T2924 prep of,heritability
R583 T2927 T2928 det these,defects
R584 T3035 T3024 auxpass be,investigated
R585 T2928 T2926 pobj defects,of
R586 T2929 T2925 acomp unclear,is
R587 T3036 T3024 prep in,investigated
R588 T3037 T3038 amod human,populations
R589 T2930 T2925 punct ", ",is
R590 T2931 T2932 mark as,limit
R591 T3038 T3036 pobj populations,in
R592 T2932 T2925 advcl limit,is
R593 T2933 T2934 det the,morbidity
R594 T3039 T2998 punct .,is
R595 T2934 T2932 nsubj morbidity,limit
R596 T2935 T2934 amod high,morbidity
R597 T2936 T2934 cc and,morbidity
R598 T3041 T3042 nsubj We,screened
R599 T2937 T2934 conj mortality,morbidity
R600 T2938 T2939 det the,collection
R601 T2939 T2932 dobj collection,limit
R602 T2940 T2939 prep of,collection
R603 T3043 T3042 dobj mice,screened
R604 T2941 T2942 amod multigenerational,families
R605 T2942 T2940 pobj families,of
R606 T2943 T2939 prep for,collection
R607 T2944 T2943 pobj analysis,for
R608 T2945 T2925 punct .,is
R609 T3044 T3043 acl treated,mice
R610 T2947 T2948 det The,etiologies
R611 T2948 T2950 nsubj etiologies,are
R612 T2949 T2948 amod genetic,etiologies
R613 T3045 T3044 prep with,treated
R614 T2951 T2950 acomp likely,are
R615 T2952 T2953 aux to,be
R616 T3046 T3047 det the,mutagen
R617 T2953 T2951 xcomp be,likely
R618 T2954 T2953 acomp complex,be
R619 T3047 T3045 pobj mutagen,with
R620 T2955 T2950 cc and,are
R621 T2956 T2957 advmod probably,arise
R622 T2957 T2950 conj arise,are
R623 T3048 T3047 amod chemical,mutagen
R624 T2958 T2957 prep from,arise
R625 T2959 T2960 amod different,mutations
R626 T2960 T2958 pobj mutations,from
R627 T3049 T3050 compound N,ethyl
R628 T2961 T2957 prep in,arise
R629 T2962 T2963 amod various,parts
R630 T2963 T2961 pobj parts,in
R631 T2964 T2963 prep of,parts
R632 T3050 T3047 appos ethyl,mutagen
R633 T2965 T2966 det the,pathways
R634 T2966 T2964 pobj pathways,of
R635 T3051 T3050 punct -,ethyl
R636 T2967 T2966 amod molecular,pathways
R637 T2968 T2966 amod developmental,pathways
R638 T2969 T2966 acl required,pathways
R639 T3052 T3050 punct -,ethyl
R640 T2970 T2969 prep for,required
R641 T2971 T2972 amod diaphragmatic,development
R642 T2972 T2970 pobj development,for
R643 T3053 T3054 compound N,nitrosourea
R644 T2973 T2950 punct .,are
R645 T3054 T3050 appos nitrosourea,ethyl
R646 T2975 T2976 advmod Indeed,are
R647 T3055 T3054 punct -,nitrosourea
R648 T2977 T2976 punct ", ",are
R649 T2978 T2976 expl there,are
R650 T2979 T2980 amod numerous,reports
R651 T3056 T3050 punct (,ethyl
R652 T2980 T2976 attr reports,are
R653 T2981 T2980 acl implicating,reports
R654 T2982 T2983 amod different,abnormalities
R655 T2983 T2981 dobj abnormalities,implicating
R656 T3057 T3050 appos ENU,ethyl
R657 T2984 T2983 amod chromosomal,abnormalities
R658 T2985 T2981 prep in,implicating
R659 T2986 T2987 det the,pathogenesis
R660 T2987 T2985 pobj pathogenesis,in
R661 T2988 T2987 prep of,pathogenesis
R662 T3058 T3042 punct ),screened
R663 T2989 T2988 pobj CDH,of
R664 T2990 T2991 punct [,13
R665 T2991 T2976 parataxis 13,are
R666 T3059 T3042 prep for,screened
R667 T2992 T2991 nummod 12,13
R668 T2993 T2991 punct ",",13
R669 T2994 T2991 punct ],13
R670 T3060 T3059 pobj lines,for
R671 T2995 T2976 punct .,are
R672 T3061 T3060 prep with,lines
R673 T2997 T2998 prep Given,is
R674 T2999 T3000 det the,difficulty
R675 T3062 T3063 amod developmental,defects
R676 T3000 T2997 pobj difficulty,Given
R677 T3001 T3000 prep of,difficulty
R678 T3002 T3001 pcomp studying,of
R679 T3063 T3061 pobj defects,with
R680 T3003 T3004 amod lethal,abnormalities
R681 T3004 T3002 dobj abnormalities,studying
R682 T3064 T3065 dep that,present
R683 T3005 T3004 amod developmental,abnormalities
R684 T3006 T3002 prep in,studying
R685 T3007 T3006 pobj humans,in
R686 T3065 T3063 relcl present,defects
R687 T3008 T2998 punct ", ",is
R688 T3009 T2998 nsubj it,is
R689 T3010 T2998 prep of,is
R690 T3066 T3065 prep in,present
R691 T3011 T3012 amod great,utility
R692 T3012 T3010 pobj utility,of
R693 T3067 T3068 det the,period
R694 T3013 T3012 amod potential,utility
R695 T3014 T3015 aux to,develop
R696 T3068 T3066 pobj period,in
R697 T3069 T3068 amod perinatal,period
R698 T3070 T3071 punct [,14
R699 T3071 T3042 parataxis 14,screened
R700 T3072 T3071 punct ],14
R701 T3073 T3042 punct .,screened
R702 T3075 T3076 prep From,identified
R703 T3121 T3119 dobj mutation,revealed
R704 T3122 T3119 prep in,revealed
R705 T3123 T3124 det a,site
R706 T3124 T3122 pobj site,in
R707 T3125 T3124 compound splice,site
R708 T3126 T3124 compound donor,site
R709 T3077 T3078 det this,screen
R710 T3127 T3128 dep that,generates
R711 T3128 T3124 relcl generates,site
R712 T3129 T3130 det an,transcript
R713 T3130 T3128 dobj transcript,generates
R714 T3131 T3130 amod abnormal,transcript
R715 T3078 T3075 pobj screen,From
R716 T3132 T3130 acl encoding,transcript
R717 T3133 T3134 det a,protein
R718 T3134 T3132 dobj protein,encoding
R719 T3079 T3076 punct ", ",identified
R720 T3135 T3134 amod truncated,protein
R721 T3136 T3119 punct .,revealed
R722 T3080 T3076 nsubj we,identified
R723 T3138 T3139 det This,result
R724 T3139 T3140 nsubj result,suggested
R725 T3081 T3082 det a,line
R726 T3141 T3142 mark that,examine
R727 T3142 T3140 ccomp examine,suggested
R728 T3082 T3076 dobj line,identified
R729 T3143 T3142 nsubj we,examine
R730 T3144 T3145 det the,gene
R731 T3083 T3082 prep of,line
R732 T3145 T3142 dobj gene,examine
R733 T3146 T3145 amod orthologous,gene
R734 T3147 T3142 prep in,examine
R735 T3084 T3083 pobj mice,of
R736 T3148 T3147 pobj humans,in
R737 T3149 T3148 prep with,humans
R738 T3150 T3151 amod similar,defects
R739 T3085 T3084 acl carrying,mice
R740 T3151 T3149 pobj defects,with
R741 T3152 T3151 amod developmental,defects
R742 T3086 T3087 det a,mutation
R743 T3153 T3140 punct ", ",suggested
R744 T3154 T3140 cc and,suggested
R745 T3155 T3156 nsubj we,report
R746 T3087 T3085 dobj mutation,carrying
R747 T3156 T3140 conj report,suggested
R748 T3157 T3158 det the,finding
R749 T3088 T3087 amod recessive,mutation
R750 T3158 T3156 dobj finding,report
R751 T3159 T3158 prep of,finding
R752 T3160 T3161 det a,mutation
R753 T3089 T3090 dep that,results
R754 T3161 T3159 pobj mutation,of
R755 T3162 T3163 advmod de,novo
R756 T3163 T3161 amod novo,mutation
R757 T3164 T3161 compound nonsense,mutation
R758 T3165 T3158 prep in,finding
R759 T3166 T3165 pobj FOG2,in
R760 T3090 T3087 relcl results,mutation
R761 T3167 T3158 prep in,finding
R762 T3168 T3169 det a,patient
R763 T3091 T3090 prep in,results
R764 T3169 T3167 pobj patient,in
R765 T3170 T3171 dep who,died
R766 T3171 T3169 relcl died,patient
R767 T3172 T3171 prep at,died
R768 T3092 T3093 amod primary,hypoplasia
R769 T3173 T3172 pobj birth,at
R770 T3174 T3171 prep with,died
R771 T3093 T3091 pobj hypoplasia,in
R772 T3175 T3176 det a,defect
R773 T3176 T3174 pobj defect,with
R774 T3177 T3176 amod diaphragmatic,defect
R775 T3178 T3176 cc and,defect
R776 T3094 T3093 amod pulmonary,hypoplasia
R777 T3179 T3180 amod severe,hypoplasia
R778 T3180 T3176 conj hypoplasia,defect
R779 T3181 T3180 amod pulmonary,hypoplasia
R780 T3095 T3093 cc and,hypoplasia
R781 T3182 T3156 punct .,report
R782 T3096 T3097 amod abnormal,development
R783 T3184 T3185 nsubj This,is
R784 T3186 T3187 det the,mutation
R785 T3097 T3093 conj development,hypoplasia
R786 T3098 T3097 amod diaphragmatic,development
R787 T3099 T3098 cc and,diaphragmatic
R788 T3187 T3185 attr mutation,is
R789 T3100 T3098 conj cardiac,diaphragmatic
R790 T3188 T3187 amod first,mutation
R791 T3189 T3187 amod reported,mutation
R792 T3190 T3187 amod associated,mutation
R793 T3101 T3076 punct .,identified
R794 T3191 T3190 prep with,associated
R795 T3192 T3193 det these,abnormalities
R796 T3193 T3191 pobj abnormalities,with
R797 T3103 T3104 amod Positional,analysis
R798 T3194 T3185 prep in,is
R799 T3195 T3196 det a,human
R800 T3196 T3194 pobj human,in
R801 T3197 T3185 punct .,is
R802 T3104 T3106 nsubj analysis,identified
R803 T3199 T3200 nsubj We,present
R804 T3105 T3104 compound cloning,analysis
R805 T3201 T3202 amod additional,data
R806 T3202 T3200 dobj data,present
R807 T3107 T3106 dobj Fog2,identified
R808 T3203 T3204 dep that,provide
R809 T3204 T3202 relcl provide,data
R810 T3205 T3206 amod direct,evidence
R811 T3206 T3204 dobj evidence,provide
R812 T3207 T3208 mark that,be
R813 T3208 T3206 acl be,evidence
R814 T3108 T3109 punct (,Zfpm2
R815 T3209 T3210 amod pulmonary,hypoplasia
R816 T3210 T3208 nsubj hypoplasia,be
R817 T3109 T3107 parataxis Zfpm2,Fog2
R818 T3211 T3208 aux may,be
R819 T3212 T3213 det a,component
R820 T3213 T3208 attr component,be
R821 T3110 T3109 punct ),Zfpm2
R822 T3214 T3213 amod primary,component
R823 T3215 T3213 prep of,component
R824 T3216 T3217 det this,spectrum
R825 T3111 T3106 prep as,identified
R826 T3217 T3215 pobj spectrum,of
R827 T3218 T3217 prep of,spectrum
R828 T3219 T3218 pobj disorders,of
R829 T3112 T3113 det a,candidate
R830 T3220 T3200 punct .,present
R831 T3113 T3111 pobj candidate,as
R832 T3114 T3113 amod likely,candidate
R833 T3115 T3106 punct ", ",identified
R834 T3116 T3106 cc and,identified
R835 T3117 T3118 compound DNA,sequencing
R836 T3118 T3119 nsubj sequencing,revealed
R837 T3119 T3106 conj revealed,identified
R838 T3120 T3121 det a,mutation
R839 T5357 T5356 prep of,Identification
R840 T5358 T5359 det the,Mutation
R841 T5359 T5357 pobj Mutation,of
R842 T5360 T5361 amod little,lung
R843 T5361 T5359 compound lung,Mutation
R844 T5362 T5356 prep in,Identification
R845 T5363 T5362 pobj Fog2,in
R846 T5365 T5366 nsubj We,screened
R847 T5367 T5368 amod third,generation
R848 T5368 T5370 compound generation,progeny
R849 T5369 T5368 punct -,generation
R850 T5370 T5366 dobj progeny,screened
R851 T5371 T5370 prep of,progeny
R852 T5372 T5373 npadvmod ENU,mutagenized
R853 T5373 T5375 amod mutagenized,mice
R854 T5374 T5373 punct -,mutagenized
R855 T5375 T5371 pobj mice,of
R856 T5376 T5366 prep at,screened
R857 T5377 T5378 amod embryonic,day
R858 T5378 T5376 pobj day,at
R859 T5379 T5378 nummod 18.5,day
R860 T5380 T5378 punct (,day
R861 T5381 T5378 appos E18.5,day
R862 T5382 T5366 punct ),screened
R863 T5383 T5366 prep for,screened
R864 T5384 T5385 amod abnormal,phenotypes
R865 T5385 T5383 pobj phenotypes,for
R866 T5386 T5385 amod developmental,phenotypes
R867 T5387 T5388 punct [,14
R868 T5388 T5366 parataxis 14,screened
R869 T5389 T5388 punct ],14
R870 T5390 T5366 punct .,screened
R871 T5392 T5393 nummod One,line
R872 T5393 T5394 nsubjpass line,found
R873 T5395 T5393 prep of,line
R874 T5396 T5395 pobj mice,of
R875 T5397 T5394 auxpass was,found
R876 T5398 T5399 aux to,have
R877 T5399 T5394 xcomp have,found
R878 T5400 T5401 amod multiple,embryos
R879 T5401 T5399 dobj embryos,have
R880 T5402 T5401 prep in,embryos
R881 T5403 T5404 amod independent,litters
R882 T5404 T5402 pobj litters,in
R883 T5405 T5406 dep that,displayed
R884 T5406 T5401 relcl displayed,embryos
R885 T5407 T5408 amod pulmonary,hypoplasia
R886 T5408 T5406 dobj hypoplasia,displayed
R887 T5409 T5408 cc and,hypoplasia
R888 T5410 T5411 det a,diaphragm
R889 T5411 T5408 conj diaphragm,hypoplasia
R890 T5412 T5411 amod thin,diaphragm
R891 T5413 T5394 punct .,found
R892 T5415 T5416 det The,mutation
R893 T5416 T5417 nsubjpass mutation,mapped
R894 T5418 T5416 punct ", ",mutation
R895 T5419 T5420 dep which,called
R896 T5420 T5416 relcl called,mutation
R897 T5421 T5420 nsubj we,called
R898 T5422 T5423 amod little,lung
R899 T5423 T5420 oprd lung,called
R900 T5424 T5423 punct (,lung
R901 T5425 T5423 appos lil,lung
R902 T5426 T5423 punct ),lung
R903 T5427 T5417 punct ", ",mapped
R904 T5428 T5417 auxpass was,mapped
R905 T5429 T5417 prep to,mapped
R906 T5430 T5429 pobj Chromosome,to
R907 T5431 T5430 nummod 15,Chromosome
R908 T5432 T5417 prep by,mapped
R909 T5433 T5432 pcomp utilizing,by
R910 T5434 T5435 det a,strategy
R911 T5435 T5433 dobj strategy,utilizing
R912 T5442 T5441 nsubj data,shown
R913 T5436 T5435 prep of,strategy
R914 T5443 T5441 neg not,shown
R915 T5444 T5441 punct ),shown
R916 T5437 T5438 amod interval,analysis
R917 T5445 T5446 punct [,15
R918 T5446 T5417 parataxis 15,mapped
R919 T5438 T5436 pobj analysis,of
R920 T5447 T5446 punct ],15
R921 T5448 T5417 punct .,mapped
R922 T5439 T5438 compound haplotype,analysis
R923 T5450 T5451 prep For,analyzed
R924 T5440 T5441 punct (,shown
R925 T5452 T5453 amod high,resolution
R926 T5441 T5417 parataxis shown,mapped
R927 T5453 T5455 compound resolution,mapping
R928 T5454 T5453 punct -,resolution
R929 T5455 T5450 pobj mapping,For
R930 T5548 T5549 compound flanking,markers
R931 T5456 T5451 punct ", ",analyzed
R932 T5457 T5458 compound F2,progeny
R933 T5458 T5451 nsubjpass progeny,analyzed
R934 T5549 T5544 dobj markers,D15Mit5
R935 T5459 T5458 prep from,progeny
R936 T5460 T5461 nummod two,crosses
R937 T5461 T5459 pobj crosses,from
R938 T5550 T5535 punct .,established
R939 T5462 T5451 auxpass were,analyzed
R940 T5463 T5451 punct .,analyzed
R941 T5465 T5466 prep In,defined
R942 T5552 T5553 det The,phenotype
R943 T5467 T5468 nummod 450,progeny
R944 T5468 T5465 pobj progeny,In
R945 T5469 T5468 prep of,progeny
R946 T5470 T5471 det an,intercross
R947 T5553 T5555 nsubjpass phenotype,identified
R948 T5471 T5469 pobj intercross,of
R949 T5472 T5471 prep of,intercross
R950 T5473 T5474 nmod F1,mice
R951 T5554 T5553 compound lil,phenotype
R952 T5474 T5472 pobj mice,of
R953 T5475 T5476 punct (,J
R954 T5556 T5555 auxpass was,identified
R955 T5476 T5474 nmod J,mice
R956 T5477 T5476 nmod A,J
R957 T5478 T5476 punct /,J
R958 T5479 T5476 punct ×,J
R959 T5480 T5481 compound FVB,N
R960 T5481 T5476 appos N,J
R961 T5557 T5555 prep at,identified
R962 T5482 T5481 punct /,N
R963 T5483 T5476 punct ),J
R964 T5484 T5474 nmod lil,mice
R965 T5485 T5484 punct /,lil
R966 T5558 T5557 pobj E18.5,at
R967 T5486 T5484 punct +,lil
R968 T5487 T5466 punct ", ",defined
R969 T5488 T5489 det the,interval
R970 T5559 T5560 aux to,have
R971 T5489 T5466 nsubjpass interval,defined
R972 T5490 T5489 acl containing,interval
R973 T5491 T5492 det the,mutation
R974 T5560 T5555 xcomp have,identified
R975 T5492 T5490 dobj mutation,containing
R976 T5493 T5466 auxpass was,defined
R977 T5494 T5466 prep by,defined
R978 T5561 T5562 amod bilateral,hypoplasia
R979 T5495 T5496 nummod 19,recombinants
R980 T5496 T5494 pobj recombinants,by
R981 T5497 T5496 prep between,recombinants
R982 T5562 T5560 dobj hypoplasia,have
R983 T5498 T5497 pobj D15Mit220,between
R984 T5499 T5498 cc and,D15Mit220
R985 T5500 T5498 conj D15Mit154,D15Mit220
R986 T5563 T5562 amod pulmonary,hypoplasia
R987 T5501 T5466 punct .,defined
R988 T5564 T5562 cc and,hypoplasia
R989 T5503 T5504 prep Because,tested
R990 T5505 T5503 pcomp of,Because
R991 T5506 T5507 det the,lack
R992 T5565 T5566 det an,diaphragm
R993 T5507 T5503 pobj lack,Because
R994 T5508 T5507 prep of,lack
R995 T5509 T5510 amod informative,markers
R996 T5510 T5508 pobj markers,of
R997 T5566 T5562 conj diaphragm,hypoplasia
R998 T5567 T5566 amod abnormal,diaphragm
R999 T5511 T5507 prep within,lack
R1000 T5568 T5555 punct .,identified
R1001 T5512 T5513 det this,interval
R1002 T5570 T5571 amod Pulmonary,hypoplasia
R1003 T5513 T5511 pobj interval,within
R1004 T5514 T5504 punct ", ",tested
R1005 T5515 T5516 quantmod an,39
R1006 T5516 T5518 nummod 39,progeny
R1007 T5571 T5572 nsubj hypoplasia,was
R1008 T5517 T5516 amod additional,39
R1009 T5518 T5504 nsubjpass progeny,tested
R1010 T5573 T5572 acomp apparent,was
R1011 T5519 T5518 compound F2,progeny
R1012 T5520 T5518 prep from,progeny
R1013 T5521 T5522 det an,cross
R1014 T5574 T5572 prep in,was
R1015 T5522 T5520 pobj cross,from
R1016 T5523 T5524 nmod A,J
R1017 T5524 T5522 nmod J,cross
R1018 T5575 T5576 det all,mice
R1019 T5525 T5524 punct /,J
R1020 T5526 T5524 punct ×,J
R1021 T5576 T5574 pobj mice,in
R1022 T5527 T5528 compound C57BL,6J
R1023 T5528 T5524 appos 6J,J
R1024 T5529 T5528 punct /,6J
R1025 T5530 T5504 auxpass were,tested
R1026 T5577 T5576 compound mutant,mice
R1027 T5531 T5504 punct .,tested
R1028 T5578 T5579 dep that,survived
R1029 T5533 T5534 det The,identification
R1030 T5534 T5535 nsubj identification,established
R1031 T5579 T5576 relcl survived,mice
R1032 T5536 T5534 prep of,identification
R1033 T5537 T5538 nummod two,recombinants
R1034 T5538 T5536 pobj recombinants,of
R1035 T5539 T5535 dobj D15Mit85,established
R1036 T5580 T5579 prep to,survived
R1037 T5540 T5535 prep as,established
R1038 T5541 T5542 det the,proximal
R1039 T5542 T5540 pobj proximal,as
R1040 T5581 T5580 pobj birth,to
R1041 T5543 T5535 cc and,established
R1042 T5544 T5535 conj D15Mit5,established
R1043 T5582 T5572 punct .,was
R1044 T5545 T5544 prep as,D15Mit5
R1045 T5546 T5547 det the,distal
R1046 T5547 T5545 pobj distal,as
R1047 T5584 T5585 prep In,were
R1048 T5586 T5587 det a,comparison
R1049 T5587 T5584 pobj comparison,In
R1050 T5655 T5653 prep from,lungs
R1051 T5656 T5657 compound mutant,mice
R1052 T5588 T5587 prep between,comparison
R1053 T5657 T5655 pobj mice,from
R1054 T5658 T5654 aux were,lacking
R1055 T5659 T5660 det an,lobe
R1056 T5589 T5590 amod wild,type
R1057 T5660 T5654 dobj lobe,lacking
R1058 T5661 T5660 amod accessory,lobe
R1059 T5590 T5592 nmod type,mice
R1060 T5662 T5654 prep on,lacking
R1061 T5663 T5664 det the,side
R1062 T5664 T5662 pobj side,on
R1063 T5591 T5590 punct -,type
R1064 T5665 T5664 amod right,side
R1065 T5592 T5588 pobj mice,between
R1066 T5666 T5654 cc and,lacking
R1067 T5667 T5654 conj had,lacking
R1068 T5668 T5667 dobj underdevelopment,had
R1069 T5669 T5668 prep of,underdevelopment
R1070 T5593 T5590 cc and,type
R1071 T5670 T5671 det the,lobe
R1072 T5671 T5669 pobj lobe,of
R1073 T5672 T5671 amod anterior,lobe
R1074 T5594 T5590 conj mutant,type
R1075 T5673 T5671 amod right,lobe
R1076 T5674 T5671 amod middle,lobe
R1077 T5595 T5592 acl found,mice
R1078 T5675 T5676 punct (,Figure
R1079 T5676 T5667 parataxis Figure,had
R1080 T5677 T5676 nummod 1A,Figure
R1081 T5596 T5595 oprd dead,found
R1082 T5678 T5676 punct ),Figure
R1083 T5679 T5654 punct .,lacking
R1084 T5597 T5595 prep on,found
R1085 T5681 T5682 nsubj Diaphragms,were
R1086 T5683 T5681 prep from,Diaphragms
R1087 T5598 T5597 pobj day,on
R1088 T5684 T5685 compound mutant,mice
R1089 T5685 T5683 pobj mice,from
R1090 T5686 T5685 compound lil,mice
R1091 T5599 T5598 nummod one,day
R1092 T5600 T5598 prep of,day
R1093 T5687 T5682 acomp intact,were
R1094 T5688 T5682 punct ", ",were
R1095 T5689 T5682 cc but,were
R1096 T5601 T5600 pobj life,of
R1097 T5690 T5691 nsubj muscularization,was
R1098 T5691 T5682 conj was,were
R1099 T5692 T5691 acomp absent,was
R1100 T5693 T5691 prep in,was
R1101 T5694 T5695 det the,regions
R1102 T5695 T5693 pobj regions,in
R1103 T5602 T5585 punct ", ",were
R1104 T5696 T5695 amod dorsal,regions
R1105 T5697 T5691 punct .,was
R1106 T5603 T5604 compound body,weights
R1107 T5699 T5700 nsubj Myotubules,were
R1108 T5701 T5700 acomp present,were
R1109 T5604 T5605 nsubj weights,were
R1110 T5702 T5700 prep in,were
R1111 T5703 T5704 det a,distribution
R1112 T5704 T5702 pobj distribution,in
R1113 T5705 T5704 amod limited,distribution
R1114 T5605 T5585 ccomp were,were
R1115 T5706 T5705 cc and,limited
R1116 T5707 T5705 conj abnormal,limited
R1117 T5708 T5700 punct .,were
R1118 T5606 T5605 neg not,were
R1119 T5710 T5711 advmod More,specifically
R1120 T5607 T5605 acomp different,were
R1121 T5711 T5712 advmod specifically,radiate
R1122 T5713 T5712 punct ", ",radiate
R1123 T5608 T5585 punct ;,were
R1124 T5714 T5712 nsubj myotubules,radiate
R1125 T5715 T5712 advmod normally,radiate
R1126 T5716 T5712 prep in,radiate
R1127 T5717 T5718 det a,fashion
R1128 T5609 T5585 advmod however,were
R1129 T5718 T5716 pobj fashion,in
R1130 T5719 T5718 amod mediolateral,fashion
R1131 T5610 T5585 punct ", ",were
R1132 T5720 T5721 aux to,meet
R1133 T5721 T5712 advcl meet,radiate
R1134 T5722 T5723 det the,walls
R1135 T5611 T5612 det the,weights
R1136 T5723 T5721 dobj walls,meet
R1137 T5724 T5723 amod lateral,walls
R1138 T5725 T5723 compound body,walls
R1139 T5726 T5712 punct ", ",radiate
R1140 T5612 T5585 nsubj weights,were
R1141 T5727 T5712 prep with,radiate
R1142 T5728 T5729 det a,paucity
R1143 T5613 T5612 compound lung,weights
R1144 T5729 T5727 pobj paucity,with
R1145 T5730 T5729 amod normal,paucity
R1146 T5731 T5729 prep of,paucity
R1147 T5614 T5615 advmod significantly,lower
R1148 T5732 T5733 compound muscle,fibers
R1149 T5733 T5731 pobj fibers,of
R1150 T5734 T5729 prep in,paucity
R1151 T5735 T5736 det the,region
R1152 T5736 T5734 pobj region,in
R1153 T5737 T5736 amod central,region
R1154 T5738 T5736 amod tendonous,region
R1155 T5615 T5585 acomp lower,were
R1156 T5739 T5712 punct .,radiate
R1157 T5616 T5585 prep in,were
R1158 T5741 T5742 prep In,radiated
R1159 T5617 T5618 det the,mice
R1160 T5743 T5744 det the,diaphragm
R1161 T5744 T5741 pobj diaphragm,In
R1162 T5745 T5744 compound mutant,diaphragm
R1163 T5746 T5742 punct ", ",radiated
R1164 T5618 T5616 pobj mice,in
R1165 T5747 T5742 nsubj myotubules,radiated
R1166 T5748 T5742 prep in,radiated
R1167 T5749 T5750 det a,orientation
R1168 T5619 T5618 compound mutant,mice
R1169 T5750 T5748 pobj orientation,in
R1170 T5751 T5752 amod dorsal,ventral
R1171 T5620 T5585 punct .,were
R1172 T5752 T5750 amod ventral,orientation
R1173 T5753 T5752 punct –,ventral
R1174 T5754 T5742 punct ", ",radiated
R1175 T5622 T5623 det The,weight
R1176 T5755 T5742 cc and,radiated
R1177 T5756 T5757 compound muscle,tissue
R1178 T5757 T5758 nsubj tissue,meet
R1179 T5758 T5742 conj meet,radiated
R1180 T5623 T5627 nsubj weight,was
R1181 T5759 T5758 aux did,meet
R1182 T5624 T5623 amod average,weight
R1183 T5625 T5626 compound mutant,lung
R1184 T5626 T5623 compound lung,weight
R1185 T5760 T5758 neg not,meet
R1186 T5761 T5762 det the,surface
R1187 T5628 T5629 quantmod 9.6,2.5
R1188 T5762 T5758 dobj surface,meet
R1189 T5763 T5762 amod entire,surface
R1190 T5764 T5762 prep of,surface
R1191 T5765 T5766 det the,walls
R1192 T5629 T5631 nummod 2.5,mg
R1193 T5766 T5764 pobj walls,of
R1194 T5767 T5766 compound body,walls
R1195 T5768 T5769 punct (,Figure
R1196 T5630 T5629 punct ±,2.5
R1197 T5769 T5758 parataxis Figure,meet
R1198 T5770 T5769 nummod 1B,Figure
R1199 T5771 T5769 punct ),Figure
R1200 T5631 T5627 attr mg,was
R1201 T5772 T5758 punct .,meet
R1202 T5774 T5775 det The,number
R1203 T5632 T5633 mark while,was
R1204 T5775 T5776 nsubj number,was
R1205 T5633 T5627 advcl was,was
R1206 T5777 T5775 prep of,number
R1207 T5778 T5779 compound lil,mice
R1208 T5634 T5635 det the,weight
R1209 T5779 T5777 pobj mice,of
R1210 T5780 T5779 compound mutant,mice
R1211 T5781 T5782 dep that,survived
R1212 T5635 T5633 nsubj weight,was
R1213 T5782 T5779 relcl survived,mice
R1214 T5783 T5782 prep to,survived
R1215 T5784 T5783 pobj birth,to
R1216 T5636 T5635 amod average,weight
R1217 T5785 T5786 amod less,5
R1218 T5786 T5788 nummod 5,%
R1219 T5787 T5786 quantmod than,5
R1220 T5637 T5638 amod wild,type
R1221 T5788 T5776 attr %,was
R1222 T5789 T5788 prep of,%
R1223 T5638 T5640 compound type,lung
R1224 T5790 T5791 amod total,progeny
R1225 T5791 T5789 pobj progeny,of
R1226 T5792 T5776 punct ", ",was
R1227 T5793 T5794 advmod rather,than
R1228 T5639 T5638 punct -,type
R1229 T5794 T5776 prep than,was
R1230 T5795 T5796 det the,%
R1231 T5640 T5635 compound lung,weight
R1232 T5796 T5794 pobj %,than
R1233 T5797 T5796 nummod 25,%
R1234 T5641 T5642 quantmod 26.4,4.6
R1235 T5642 T5644 nummod 4.6,mg
R1236 T5798 T5796 acl expected,%
R1237 T5799 T5798 prep for,expected
R1238 T5643 T5642 punct ±,4.6
R1239 T5800 T5801 det a,mutation
R1240 T5801 T5799 pobj mutation,for
R1241 T5802 T5801 amod recessive,mutation
R1242 T5644 T5633 attr mg,was
R1243 T5803 T5776 punct .,was
R1244 T5645 T5646 punct (,0.001
R1245 T5805 T5806 nsubj We,evaluated
R1246 T5807 T5806 dobj litters,evaluated
R1247 T5646 T5627 parataxis 0.001,was
R1248 T5808 T5806 prep at,evaluated
R1249 T5809 T5810 amod different,points
R1250 T5810 T5808 pobj points,at
R1251 T5647 T5646 nsubj p,0.001
R1252 T5811 T5810 amod embryonic,points
R1253 T5812 T5810 compound time,points
R1254 T5813 T5814 aux to,determine
R1255 T5814 T5806 advcl determine,evaluated
R1256 T5815 T5816 mark whether,was
R1257 T5816 T5814 ccomp was,determine
R1258 T5648 T5646 punct <,0.001
R1259 T5817 T5818 det the,number
R1260 T5818 T5816 nsubj number,was
R1261 T5819 T5818 amod reduced,number
R1262 T5820 T5816 prep due,was
R1263 T5649 T5646 punct ),0.001
R1264 T5821 T5820 pcomp to,due
R1265 T5822 T5823 amod intra-uterine,demise
R1266 T5650 T5627 punct .,was
R1267 T5823 T5820 pobj demise,due
R1268 T5824 T5806 punct .,evaluated
R1269 T5826 T5827 nsubjpass Litters,collected
R1270 T5652 T5653 det All,lungs
R1271 T5828 T5827 auxpass were,collected
R1272 T5829 T5827 prep at,collected
R1273 T5830 T5829 pobj E12.5,at
R1274 T5653 T5654 nsubj lungs,lacking
R1275 T5831 T5830 punct ", ",E12.5
R1276 T5832 T5830 nummod 13.5,E12.5
R1277 T5833 T5830 punct ", ",E12.5
R1278 T5867 T5868 det a,rate
R1279 T5834 T5830 nummod 15.5,E12.5
R1280 T5835 T5830 punct ", ",E12.5
R1281 T5836 T5830 nummod 17.5,E12.5
R1282 T5837 T5830 punct ", ",E12.5
R1283 T5838 T5830 cc and,E12.5
R1284 T5839 T5830 conj 18.5,E12.5
R1285 T5840 T5827 punct ", ",collected
R1286 T5841 T5827 cc and,collected
R1287 T5842 T5843 nsubjpass embryos,genotyped
R1288 T5868 T5866 dobj rate,had
R1289 T5843 T5827 conj genotyped,collected
R1290 T5844 T5843 auxpass were,genotyped
R1291 T5845 T5843 cc and,genotyped
R1292 T5869 T5870 advmod progressively,higher
R1293 T5846 T5843 conj evaluated,genotyped
R1294 T5847 T5846 prep for,evaluated
R1295 T5848 T5847 pobj evidence,for
R1296 T5870 T5868 amod higher,rate
R1297 T5849 T5848 prep of,evidence
R1298 T5850 T5851 amod intra-uterine,demise
R1299 T5871 T5868 prep of,rate
R1300 T5851 T5849 pobj demise,of
R1301 T5852 T5848 punct ", ",evidence
R1302 T5853 T5848 prep including,evidence
R1303 T5872 T5871 pobj demise,of
R1304 T5854 T5855 compound growth,retardation
R1305 T5855 T5853 pobj retardation,including
R1306 T5856 T5855 punct ", ",retardation
R1307 T5857 T5855 conj pallor,retardation
R1308 T5858 T5857 punct ", ",pallor
R1309 T5873 T5866 prep between,had
R1310 T5859 T5857 cc and,pallor
R1311 T5860 T5861 compound tissue,friability
R1312 T5874 T5873 pobj E13.5,between
R1313 T5861 T5857 conj friability,pallor
R1314 T5875 T5874 cc and,E13.5
R1315 T5862 T5843 punct .,genotyped
R1316 T5876 T5874 conj E15.5,E13.5
R1317 T5864 T5865 compound lil,embryos
R1318 T5865 T5866 nsubj embryos,had
R1319 T5877 T5866 punct .,had
R1320 T5879 T5880 prep At,were
R1321 T5881 T5879 pobj E12.5,At
R1322 T5972 T5973 advmod only,embryo
R1323 T5973 T5970 nsubj embryo,was
R1324 T5882 T5880 punct ", ",were
R1325 T5974 T5973 nummod one,embryo
R1326 T5975 T5970 acomp viable,was
R1327 T5976 T5953 punct .,were
R1328 T5883 T5884 quantmod 20,87
R1329 T5978 T5979 amod Diaphragmatic,muscularization
R1330 T5979 T5980 nsubj muscularization,was
R1331 T5884 T5880 nsubj 87,were
R1332 T5981 T5980 acomp abnormal,was
R1333 T5982 T5980 prep in,was
R1334 T5885 T5884 quantmod out,87
R1335 T5983 T5984 det all,mice
R1336 T5886 T5884 quantmod of,87
R1337 T5984 T5982 pobj mice,in
R1338 T5887 T5888 punct (,%
R1339 T5985 T5984 compound mutant,mice
R1340 T5986 T5984 acl examined,mice
R1341 T5987 T5988 punct (,25
R1342 T5988 T5980 parataxis 25,was
R1343 T5888 T5884 parataxis %,87
R1344 T5989 T5988 nsubj n,25
R1345 T5990 T5988 punct >,25
R1346 T5991 T5988 punct ),25
R1347 T5889 T5888 nummod 23,%
R1348 T5992 T5980 punct .,was
R1349 T5890 T5888 punct ),%
R1350 T5994 T5995 amod Pulmonary,hypoplasia
R1351 T5995 T5996 nsubjpass hypoplasia,observed
R1352 T5891 T5880 acomp homozygous,were
R1353 T5997 T5996 auxpass was,observed
R1354 T5998 T5996 prep in,observed
R1355 T5999 T6000 nummod 100,%
R1356 T5892 T5891 prep for,homozygous
R1357 T6000 T5998 pobj %,in
R1358 T6001 T6000 prep of,%
R1359 T6002 T6001 pobj mutants,of
R1360 T6003 T6002 acl evaluated,mutants
R1361 T6004 T6003 prep for,evaluated
R1362 T6005 T6006 det that,phenotype
R1363 T5893 T5894 det the,mutation
R1364 T6006 T6004 pobj phenotype,for
R1365 T6007 T6003 prep between,evaluated
R1366 T6008 T6007 pobj E11.5,between
R1367 T5894 T5892 pobj mutation,for
R1368 T6009 T6008 cc and,E11.5
R1369 T6010 T6008 conj birth,E11.5
R1370 T6011 T6012 punct (,50
R1371 T5895 T5880 punct ", ",were
R1372 T6012 T5996 parataxis 50,observed
R1373 T6013 T6012 nsubj n,50
R1374 T6014 T6012 punct >,50
R1375 T6015 T6012 punct ),50
R1376 T5896 T5880 cc and,were
R1377 T6016 T5996 punct .,observed
R1378 T5897 T5898 nsubj all,appeared
R1379 T6018 T6019 nsubj Examination,showed
R1380 T6020 T6018 prep of,Examination
R1381 T5898 T5880 conj appeared,were
R1382 T5899 T5897 prep of,all
R1383 T6021 T6022 amod cardiac,morphology
R1384 T5900 T5899 pobj these,of
R1385 T6022 T6020 pobj morphology,of
R1386 T6023 T6024 mark that,had
R1387 T6024 T6019 ccomp had,showed
R1388 T5901 T5898 oprd viable,appeared
R1389 T6025 T6024 nsubj hearts,had
R1390 T6026 T6025 prep from,hearts
R1391 T5902 T5880 punct .,were
R1392 T6027 T6028 compound E15.5,mice
R1393 T5904 T5905 prep At,were
R1394 T6028 T6026 pobj mice,from
R1395 T6029 T6030 compound lil,mutant
R1396 T6030 T6028 compound mutant,mice
R1397 T6031 T6032 det a,variety
R1398 T6032 T6024 dobj variety,had
R1399 T5906 T5904 pobj E13.5,At
R1400 T6033 T6032 prep of,variety
R1401 T6034 T6035 amod developmental,defects
R1402 T6035 T6033 pobj defects,of
R1403 T6036 T6032 punct ", ",variety
R1404 T5907 T5905 punct ", ",were
R1405 T6037 T6032 prep including,variety
R1406 T6038 T6039 amod enlarged,cushions
R1407 T5908 T5909 quantmod 13,49
R1408 T5909 T5905 nsubj 49,were
R1409 T6039 T6037 pobj cushions,including
R1410 T6040 T6038 cc and,enlarged
R1411 T6041 T6042 advmod abnormally,developed
R1412 T6042 T6038 conj developed,enlarged
R1413 T6043 T6039 amod endocardial,cushions
R1414 T6044 T6039 punct ", ",cushions
R1415 T5910 T5909 quantmod of,49
R1416 T6045 T6046 det a,ventricle
R1417 T6046 T6039 conj ventricle,cushions
R1418 T6047 T6048 amod double,outlet
R1419 T5911 T5912 punct (,%
R1420 T6048 T6046 nmod outlet,ventricle
R1421 T6049 T6048 punct -,outlet
R1422 T6050 T6046 amod right,ventricle
R1423 T5912 T5909 parataxis %,49
R1424 T6051 T6046 punct ", ",ventricle
R1425 T6052 T6046 cc and,ventricle
R1426 T6053 T6054 det a,canal
R1427 T5913 T5912 nummod 27,%
R1428 T6054 T6046 conj canal,ventricle
R1429 T6055 T6054 amod complete,canal
R1430 T6056 T6054 amod atrioventricular,canal
R1431 T5914 T5912 punct ),%
R1432 T6057 T6019 punct .,showed
R1433 T5915 T5905 acomp mutant,were
R1434 T6059 T6060 det The,myocardium
R1435 T6060 T6061 nsubj myocardium,was
R1436 T5916 T5905 cc and,were
R1437 T6062 T6061 advmod also,was
R1438 T6063 T6064 advmod poorly,developed
R1439 T5917 T5918 nsubj two,died
R1440 T6064 T6061 acomp developed,was
R1441 T6065 T6061 punct ", ",was
R1442 T6066 T6061 prep with,was
R1443 T6067 T6066 pobj thinning,with
R1444 T5918 T5905 conj died,were
R1445 T6068 T6067 prep of,thinning
R1446 T6069 T6070 det the,layer
R1447 T5919 T5918 aux had,died
R1448 T6070 T6068 pobj layer,of
R1449 T6071 T6070 amod outer,layer
R1450 T6072 T6070 amod compact,layer
R1451 T5920 T5905 punct .,were
R1452 T6073 T6067 cc and,thinning
R1453 T6074 T6075 amod decreased,vascularity
R1454 T5922 T5923 prep At,were
R1455 T6075 T6067 conj vascularity,thinning
R1456 T6076 T6061 punct .,was
R1457 T5924 T5922 pobj E15.5,At
R1458 T5925 T5923 punct ", ",were
R1459 T6078 T6079 det The,cohort
R1460 T5926 T5927 quantmod 22,91
R1461 T6079 T6080 nsubj cohort,had
R1462 T6081 T6079 prep of,cohort
R1463 T6082 T6083 compound mutant,mice
R1464 T6083 T6081 pobj mice,of
R1465 T6084 T6085 dep that,survived
R1466 T6085 T6083 relcl survived,mice
R1467 T5927 T5923 nsubj 91,were
R1468 T6086 T6085 prep to,survived
R1469 T6087 T6086 pobj birth,to
R1470 T6088 T6080 advmod also,had
R1471 T5928 T5927 quantmod out,91
R1472 T6089 T6090 amod cardiac,malformations
R1473 T6090 T6080 dobj malformations,had
R1474 T6091 T6090 prep including,malformations
R1475 T5929 T5927 quantmod of,91
R1476 T6092 T6093 amod atrioventricular,canal
R1477 T6093 T6095 nmod canal,type
R1478 T6094 T6093 punct -,canal
R1479 T5930 T5931 punct (,%
R1480 T6095 T6097 nmod type,defects
R1481 T6096 T6095 punct -,type
R1482 T5931 T5927 parataxis %,91
R1483 T6097 T6091 pobj defects,including
R1484 T6098 T6097 amod ventricular,defects
R1485 T6099 T6097 amod septal,defects
R1486 T5932 T5931 nummod 24,%
R1487 T6100 T6097 punct ", ",defects
R1488 T6101 T6102 nmod ostium,defects
R1489 T6102 T6097 conj defects,defects
R1490 T5933 T5931 punct ),%
R1491 T6103 T6102 nmod primum,defects
R1492 T6104 T6102 amod atrial,defects
R1493 T5934 T5923 acomp mutant,were
R1494 T6105 T6102 amod septal,defects
R1495 T6106 T6102 punct ", ",defects
R1496 T6107 T6102 cc and,defects
R1497 T5935 T5923 cc and,were
R1498 T6108 T6109 amod enlarged,atria
R1499 T6109 T6102 conj atria,defects
R1500 T6110 T6111 punct (,shown
R1501 T5936 T5937 det the,majority
R1502 T6111 T6080 parataxis shown,had
R1503 T6112 T6111 nsubj data,shown
R1504 T5937 T5938 nsubj majority,died
R1505 T6113 T6111 neg not,shown
R1506 T6114 T6111 punct ),shown
R1507 T6115 T6080 punct .,had
R1508 T5938 T5923 conj died,were
R1509 T6117 T6118 det All,mutants
R1510 T6118 T6119 nsubj mutants,had
R1511 T5939 T5937 prep of,majority
R1512 T6120 T6121 advmod specifically,evaluated
R1513 T6121 T6118 acl evaluated,mutants
R1514 T6122 T6121 prep for,evaluated
R1515 T6123 T6124 det a,phenotype
R1516 T6124 T6122 pobj phenotype,for
R1517 T5940 T5941 compound mutant,embryos
R1518 T6125 T6124 amod cardiac,phenotype
R1519 T5941 T5939 pobj embryos,of
R1520 T6126 T6127 punct (,10
R1521 T6127 T6118 parataxis 10,mutants
R1522 T6128 T6127 nsubj n,10
R1523 T5942 T5943 punct (,22
R1524 T6129 T6127 punct =,10
R1525 T6130 T6127 punct ),10
R1526 T5943 T5937 parataxis 22,majority
R1527 T6131 T6132 amod abnormal,development
R1528 T6132 T6119 dobj development,had
R1529 T6133 T6132 amod cardiac,development
R1530 T6134 T6119 punct .,had
R1531 T5944 T5943 quantmod 17,22
R1532 T6136 T6137 nsubj Examination,revealed
R1533 T5945 T5943 quantmod out,22
R1534 T6138 T6136 prep of,Examination
R1535 T5946 T5943 quantmod of,22
R1536 T6139 T6140 det the,region
R1537 T6140 T6138 pobj region,of
R1538 T6141 T6142 nummod 3,Mb
R1539 T6142 T6140 compound Mb,region
R1540 T5947 T5943 quantmod the,22
R1541 T6143 T6142 punct -,Mb
R1542 T6144 T6140 prep between,region
R1543 T5948 T5943 punct ),22
R1544 T6145 T6144 pobj D15Mit85,between
R1545 T6146 T6145 cc and,D15Mit85
R1546 T6147 T6145 conj D15Mit5,D15Mit85
R1547 T5949 T5938 aux had,died
R1548 T6148 T6140 prep in,region
R1549 T6149 T6150 compound DNA,sequence
R1550 T6150 T6151 compound sequence,databases
R1551 T5950 T5938 punct .,died
R1552 T6151 T6148 pobj databases,in
R1553 T6152 T6153 nummod three,genes
R1554 T6153 T6137 dobj genes,revealed
R1555 T5952 T5953 prep By,were
R1556 T6154 T6153 amod predicted,genes
R1557 T6155 T6153 cc and,genes
R1558 T6156 T6157 nummod four,genes
R1559 T6157 T6153 conj genes,genes
R1560 T6158 T6157 amod known,genes
R1561 T5954 T5952 pobj E18.5,By
R1562 T6159 T6157 punct ", ",genes
R1563 T6160 T6157 prep including,genes
R1564 T6161 T6160 pobj Fog2,including
R1565 T6162 T6137 punct .,revealed
R1566 T6164 T6165 amod Targeted,mutations
R1567 T5955 T5953 punct ", ",were
R1568 T6165 T6166 nsubj mutations,have
R1569 T6167 T6165 prep of,mutations
R1570 T5956 T5957 quantmod nine,29
R1571 T6168 T6167 pobj Fog2,of
R1572 T6169 T6170 amod cardiac,defects
R1573 T6170 T6166 dobj defects,have
R1574 T6171 T6172 advmod strikingly,similar
R1575 T5957 T5959 nummod 29,embryos
R1576 T6172 T6170 amod similar,defects
R1577 T6173 T6172 prep to,similar
R1578 T6174 T6173 pobj those,to
R1579 T5958 T5957 quantmod of,29
R1580 T6175 T6176 nsubj we,identified
R1581 T6176 T6174 advcl identified,those
R1582 T5959 T5953 nsubj embryos,were
R1583 T6177 T6176 prep in,identified
R1584 T5960 T5961 punct (,%
R1585 T6178 T6179 compound lil,mice
R1586 T6179 T6177 pobj mice,in
R1587 T6180 T6179 compound mutant,mice
R1588 T6181 T6170 punct ", ",defects
R1589 T5961 T5959 parataxis %,embryos
R1590 T6182 T6170 prep including,defects
R1591 T6183 T6184 amod atrioventricular,defects
R1592 T5962 T5961 nummod 31,%
R1593 T5963 T5961 punct ),%
R1594 T5964 T5953 acomp homozygous,were
R1595 T6184 T6182 pobj defects,including
R1596 T5965 T5964 prep for,homozygous
R1597 T6185 T6184 compound canal,defects
R1598 T6186 T6184 punct ", ",defects
R1599 T6187 T6188 amod thinned,myocardium
R1600 T5966 T5967 det the,mutation
R1601 T6188 T6184 conj myocardium,defects
R1602 T6189 T6188 punct ", ",myocardium
R1603 T6190 T6188 cc and,myocardium
R1604 T5967 T5965 pobj mutation,for
R1605 T6191 T6192 amod absent,vasculature
R1606 T6192 T6188 conj vasculature,myocardium
R1607 T6193 T6192 amod coronary,vasculature
R1608 T5968 T5953 punct ", ",were
R1609 T5969 T5970 prep of,was
R1610 T6194 T6195 punct [,16
R1611 T5970 T5953 ccomp was,were
R1612 T6195 T6166 parataxis 16,have
R1613 T5971 T5969 pobj which,of
R1614 T6196 T6195 punct ],16
R1615 T6197 T6166 punct .,have
R1616 T6290 T6291 det a,codon
R1617 T6199 T6200 compound RT,PCR
R1618 T6200 T6202 compound PCR,amplification
R1619 T6201 T6200 punct -,PCR
R1620 T6202 T6203 nsubj amplification,revealed
R1621 T6204 T6202 prep of,amplification
R1622 T6205 T6206 det the,portion
R1623 T6206 T6204 pobj portion,of
R1624 T6207 T6206 amod proximal,portion
R1625 T6208 T6206 prep of,portion
R1626 T6209 T6208 pobj Fog2,of
R1627 T6210 T6211 amod longer,transcripts
R1628 T6211 T6203 dobj transcripts,revealed
R1629 T6291 T6289 dobj codon,introduces
R1630 T6212 T6211 prep in,transcripts
R1631 T6213 T6214 det the,mutant
R1632 T6292 T6291 compound stop,codon
R1633 T6214 T6212 pobj mutant,in
R1634 T6215 T6214 compound lil,mutant
R1635 T6216 T6211 prep than,transcripts
R1636 T6293 T6294 dep that,generates
R1637 T6217 T6216 prep in,than
R1638 T6218 T6219 det the,type
R1639 T6219 T6217 pobj type,in
R1640 T6294 T6291 relcl generates,codon
R1641 T6220 T6219 amod wild,type
R1642 T6221 T6219 punct -,type
R1643 T6295 T6296 det a,product
R1644 T6222 T6211 appos embryos,transcripts
R1645 T6223 T6224 punct (,Figure
R1646 T6224 T6203 parataxis Figure,revealed
R1647 T6296 T6294 dobj product,generates
R1648 T6225 T6224 nummod 2A,Figure
R1649 T6226 T6224 punct ),Figure
R1650 T6227 T6203 punct .,revealed
R1651 T6229 T6230 nsubj Sequencing,revealed
R1652 T6297 T6298 advmod severely,truncated
R1653 T6231 T6229 prep of,Sequencing
R1654 T6232 T6233 det the,transcript
R1655 T6298 T6296 amod truncated,product
R1656 T6233 T6231 pobj transcript,of
R1657 T6234 T6233 compound mutant,transcript
R1658 T6235 T6236 det a,mutation
R1659 T6299 T6296 compound protein,product
R1660 T6236 T6230 dobj mutation,revealed
R1661 T6237 T6236 compound point,mutation
R1662 T6238 T6236 punct (,mutation
R1663 T6300 T6301 punct (,Figure
R1664 T6239 T6236 prep from,mutation
R1665 T6240 T6239 pobj thymine,from
R1666 T6301 T6289 parataxis Figure,introduces
R1667 T6241 T6239 prep to,from
R1668 T6242 T6241 pobj cytosine,to
R1669 T6243 T6236 punct ),mutation
R1670 T6244 T6245 nummod 2,bp
R1671 T6245 T6246 npadvmod bp,after
R1672 T6246 T6230 prep after,revealed
R1673 T6302 T6301 nummod 2B,Figure
R1674 T6247 T6246 pobj position,after
R1675 T6248 T6247 nummod 301,position
R1676 T6303 T6301 punct ),Figure
R1677 T6249 T6247 punct ", ",position
R1678 T6250 T6251 dep which,is
R1679 T6251 T6247 relcl is,position
R1680 T6304 T6268 punct .,causes
R1681 T6252 T6251 prep in,is
R1682 T6253 T6254 det the,site
R1683 T6254 T6252 pobj site,in
R1684 T6306 T6307 amod Heterozygous,mice
R1685 T6255 T6254 compound splice,site
R1686 T6256 T6254 compound donor,site
R1687 T6257 T6254 prep at,site
R1688 T6258 T6259 det the,end
R1689 T6259 T6257 pobj end,at
R1690 T6307 T6310 nsubjpass mice,crossed
R1691 T6260 T6259 prep of,end
R1692 T6261 T6262 det the,exon
R1693 T6262 T6260 pobj exon,of
R1694 T6308 T6309 compound lil,mutant
R1695 T6263 T6262 amod third,exon
R1696 T6264 T6230 punct .,revealed
R1697 T6309 T6307 compound mutant,mice
R1698 T6266 T6267 det This,mutation
R1699 T6267 T6268 nsubj mutation,causes
R1700 T6311 T6310 auxpass were,crossed
R1701 T6269 T6270 det a,defect
R1702 T6270 T6268 dobj defect,causes
R1703 T6271 T6270 compound splicing,defect
R1704 T6272 T6273 dep that,results
R1705 T6312 T6310 prep with,crossed
R1706 T6273 T6270 relcl results,defect
R1707 T6274 T6273 prep in,results
R1708 T6313 T6314 det a,mutant
R1709 T6275 T6276 det the,insertion
R1710 T6276 T6274 pobj insertion,in
R1711 T6277 T6276 prep of,insertion
R1712 T6314 T6312 pobj mutant,with
R1713 T6278 T6279 nummod 85,bp
R1714 T6279 T6277 pobj bp,of
R1715 T6315 T6314 nmod Fog2,mutant
R1716 T6280 T6279 prep of,bp
R1717 T6281 T6282 amod intronic,sequence
R1718 T6316 T6315 punct +,Fog2
R1719 T6282 T6280 pobj sequence,of
R1720 T6283 T6276 prep into,insertion
R1721 T6284 T6285 det the,transcript
R1722 T6285 T6283 pobj transcript,into
R1723 T6286 T6285 compound mutant,transcript
R1724 T6317 T6315 punct /,Fog2
R1725 T6287 T6268 punct ", ",causes
R1726 T6288 T6268 cc and,causes
R1727 T6289 T6268 conj introduces,causes
R1728 T6318 T6315 punct −,Fog2
R1729 T6319 T6320 punct (,allele
R1730 T6320 T6314 parataxis allele,mutant
R1731 T6321 T6320 amod null,allele
R1732 T6322 T6320 punct ),allele
R1733 T6323 T6314 acl generated,mutant
R1734 T6324 T6323 prep by,generated
R1735 T6325 T6326 compound gene,targeting
R1736 T6326 T6324 pobj targeting,by
R1737 T6327 T6328 punct [,16
R1738 T6328 T6310 parataxis 16,crossed
R1739 T6329 T6328 punct ],16
R1740 T6330 T6310 punct .,crossed
R1741 T6332 T6333 advmod Doubly,heterozygous
R1742 T6333 T6334 amod heterozygous,mice
R1743 T6334 T6335 nsubj mice,had
R1744 T6335 T6336 ccomp had,proves
R1745 T6337 T6338 det an,phenotype
R1746 T6338 T6335 dobj phenotype,had
R1747 T6339 T6338 amod embryonic,phenotype
R1748 T6340 T6338 amod lethal,phenotype
R1749 T6341 T6336 punct ;,proves
R1750 T6342 T6343 det this,failure
R1751 T6343 T6336 nsubj failure,proves
R1752 T6344 T6345 aux to,complement
R1753 T6345 T6343 acl complement,failure
R1754 T6346 T6347 mark that,is
R1755 T6347 T6336 ccomp is,proves
R1756 T6348 T6347 nsubj lil,is
R1757 T6349 T6350 det a,mutation
R1758 T6350 T6347 attr mutation,is
R1759 T6351 T6350 prep in,mutation
R1760 T6352 T6351 pobj Fog2,in
R1761 T6353 T6336 punct .,proves
R1762 T6355 T6356 det The,phenotype
R1763 T6356 T6358 nsubj phenotype,is
R1764 T6357 T6356 amod variable,phenotype
R1765 T6359 T6356 prep of,phenotype
R1766 T6360 T6361 compound lil,mice
R1767 T6361 T6359 pobj mice,of
R1768 T6362 T6356 punct (,phenotype
R1769 T6363 T6356 amod relative,phenotype
R1770 T6364 T6363 prep to,relative
R1771 T6365 T6364 pobj that,to
R1772 T6366 T6365 acl found,that
R1773 T6367 T6366 prep for,found
R1774 T6368 T6369 det the,mutant
R1775 T6369 T6367 pobj mutant,for
R1776 T6370 T6369 nmod Fog2,mutant
R1777 T6371 T6370 amod null,Fog2
R1778 T6372 T6358 punct ),is
R1779 T6373 T6358 advmod likely,is
R1780 T6374 T6358 prep due,is
R1781 T6375 T6374 pcomp to,due
R1782 T6376 T6377 det the,generation
R1783 T6377 T6374 pobj generation,due
R1784 T6378 T6377 prep of,generation
R1785 T6379 T6380 det a,level
R1786 T6380 T6378 pobj level,of
R1787 T6381 T6380 amod low,level
R1788 T6382 T6380 prep of,level
R1789 T6383 T6384 amod normal,transcript
R1790 T6384 T6382 pobj transcript,of
R1791 T6385 T6377 prep despite,generation
R1792 T6386 T6387 det the,presence
R1793 T6387 T6385 pobj presence,despite
R1794 T6388 T6387 prep of,presence
R1795 T6389 T6390 det the,mutation
R1796 T6390 T6388 pobj mutation,of
R1797 T6391 T6392 compound splice,site
R1798 T6392 T6390 compound site,mutation
R1799 T6393 T6358 punct .,is
R1805 T8121 T8122 nmod Lung,Development
R1806 T8123 T8121 cc and,Lung
R1807 T8124 T8121 conj Diaphragm,Lung
R1808 T8125 T8122 prep in,Development
R1809 T8126 T8127 det the,Mouse
R1810 T8127 T8125 pobj Mouse,in
R1811 T8128 T8129 compound Fog2,Mutant
R1812 T8129 T8127 compound Mutant,Mouse
R1813 T8131 T8132 nsubjpass Experiments,conducted
R1814 T8133 T8132 auxpass were,conducted
R1815 T8134 T8135 aux to,evaluate
R1816 T8135 T8132 advcl evaluate,conducted
R1817 T8136 T8137 det the,role
R1818 T8137 T8135 dobj role,evaluate
R1819 T8138 T8137 prep of,role
R1820 T8139 T8138 pobj Fog2,of
R1821 T8140 T8137 prep in,role
R1822 T8141 T8142 amod pulmonary,development
R1823 T8142 T8140 pobj development,in
R1824 T8143 T8141 cc and,pulmonary
R1825 T8144 T8141 conj diaphragmatic,pulmonary
R1826 T8145 T8132 punct .,conducted
R1827 T8147 T8148 det The,phenotype
R1828 T8148 T8150 nsubjpass phenotype,characterized
R1829 T8149 T8148 amod pulmonary,phenotype
R1830 T8151 T8150 auxpass is,characterized
R1831 T8152 T8150 agent by,characterized
R1832 T8153 T8154 amod diffuse,hypoplasia
R1833 T8154 T8152 pobj hypoplasia,by
R1834 T8155 T8154 cc and,hypoplasia
R1835 T8156 T8157 amod specific,loss
R1836 T8157 T8154 conj loss,hypoplasia
R1837 T8158 T8157 prep of,loss
R1838 T8159 T8160 det the,lobe
R1839 T8160 T8158 pobj lobe,of
R1840 T8161 T8160 amod accessory,lobe
R1841 T8162 T8160 cc and,lobe
R1842 T8163 T8164 det a,portion
R1843 T8164 T8160 conj portion,lobe
R1844 T8165 T8164 prep of,portion
R1845 T8166 T8167 det the,lobe
R1846 T8167 T8165 pobj lobe,of
R1847 T8168 T8167 amod right,lobe
R1848 T8169 T8167 amod middle,lobe
R1849 T8170 T8150 punct .,characterized
R1850 T8172 T8173 nsubj It,is
R1851 T8174 T8175 advmod well,established
R1852 T8175 T8173 acomp established,is
R1853 T8176 T8177 mark that,result
R1854 T8177 T8173 ccomp result,is
R1855 T8178 T8177 nsubj abnormalities,result
R1856 T8179 T8178 prep in,abnormalities
R1857 T8180 T8181 preconj either,development
R1858 T8181 T8179 pobj development,in
R1859 T8182 T8181 amod diaphragmatic,development
R1860 T8183 T8181 cc or,development
R1861 T8184 T8185 amod fetal,breathing
R1862 T8185 T8181 conj breathing,development
R1863 T8186 T8177 aux can,result
R1864 T8187 T8177 prep in,result
R1865 T8188 T8189 det a,hypoplasia
R1866 T8189 T8187 pobj hypoplasia,in
R1867 T8190 T8189 amod secondary,hypoplasia
R1868 T8191 T8189 amod pulmonary,hypoplasia
R1869 T8192 T8177 punct ", ",result
R1870 T8193 T8194 mark although,documented
R1871 T8194 T8177 advcl documented,result
R1872 T8195 T8194 nsubjpass loss,documented
R1873 T8196 T8195 prep of,loss
R1874 T8197 T8198 amod normal,structure
R1875 T8198 T8196 pobj structure,of
R1876 T8199 T8194 aux has,documented
R1877 T8200 T8194 neg never,documented
R1878 T8201 T8194 auxpass been,documented
R1879 T8202 T8194 prep in,documented
R1880 T8203 T8204 det this,context
R1881 T8204 T8202 pobj context,in
R1882 T8205 T8206 punct [,18
R1883 T8206 T8173 parataxis 18,is
R1884 T8207 T8206 nummod 17,18
R1885 T8208 T8206 punct ",",18
R1886 T8209 T8206 punct ],18
R1887 T8210 T8173 punct .,is
R1888 T8212 T8213 nsubjpass Fog2,expressed
R1889 T8214 T8213 auxpass is,expressed
R1890 T8215 T8213 advmod diffusely,expressed
R1891 T8216 T8213 prep in,expressed
R1892 T8217 T8218 det the,mesenchyme
R1893 T8218 T8216 pobj mesenchyme,in
R1894 T8219 T8218 amod pulmonary,mesenchyme
R1895 T8220 T8213 prep during,expressed
R1896 T8221 T8222 det the,period
R1897 T8222 T8220 pobj period,during
R1898 T8223 T8222 prep of,period
R1899 T8224 T8225 compound branching,morphogenesis
R1900 T8225 T8223 pobj morphogenesis,of
R1901 T8226 T8213 punct ", ",expressed
R1902 T8227 T8228 mark while,restricted
R1903 T8228 T8213 advcl restricted,expressed
R1904 T8229 T8230 amod later,expression
R1905 T8230 T8228 nsubjpass expression,restricted
R1906 T8231 T8228 auxpass is,restricted
R1907 T8232 T8228 prep to,restricted
R1908 T8233 T8234 det the,muscles
R1909 T8234 T8232 pobj muscles,to
R1910 T8235 T8234 amod smooth,muscles
R1911 T8236 T8234 prep of,muscles
R1912 T8237 T8236 pobj airways,of
R1913 T8238 T8237 cc and,airways
R1914 T8239 T8240 amod pulmonary,vessels
R1915 T8240 T8237 conj vessels,airways
R1916 T8241 T8242 punct (,Figure
R1917 T8242 T8213 parataxis Figure,expressed
R1918 T8243 T8242 nummod 3,Figure
R1919 T8244 T8242 punct ),Figure
R1920 T8245 T8213 punct .,expressed
R1921 T8247 T8248 nsubj This,suggests
R1922 T8249 T8247 punct ", ",This
R1923 T8250 T8247 cc and,This
R1924 T8251 T8252 det the,observation
R1925 T8252 T8247 conj observation,This
R1926 T8253 T8254 mark that,appeared
R1927 T8254 T8252 acl appeared,observation
R1928 T8255 T8254 nsubj lungs,appeared
R1929 T8256 T8254 oprd small,appeared
R1930 T8257 T8254 prep on,appeared
R1931 T8258 T8259 amod transverse,sections
R1932 T8259 T8257 pobj sections,on
R1933 T8260 T8259 acl evaluated,sections
R1934 T8261 T8262 amod prior,to
R1935 T8262 T8260 prep to,evaluated
R1936 T8263 T8264 amod diaphragmatic,muscularization
R1937 T8264 T8262 pobj muscularization,to
R1938 T8265 T8264 cc or,muscularization
R1939 T8266 T8264 conj function,muscularization
R1940 T8267 T8248 punct ", ",suggests
R1941 T8268 T8269 mark that,occurs
R1942 T8269 T8248 ccomp occurs,suggests
R1943 T8270 T8271 det the,hypoplasia
R1944 T8271 T8269 nsubj hypoplasia,occurs
R1945 T8272 T8271 amod pulmonary,hypoplasia
R1946 T8273 T8269 advmod independently,occurs
R1947 T8274 T8273 prep of,independently
R1948 T8275 T8276 det the,defect
R1949 T8276 T8274 pobj defect,of
R1950 T8277 T8276 amod diaphragmatic,defect
R1951 T8278 T8248 punct .,suggests
R1952 T8280 T8281 aux To,test
R1953 T8281 T8282 advcl test,dissected
R1954 T8283 T8284 det this,hypothesis
R1955 T8284 T8281 dobj hypothesis,test
R1956 T8285 T8282 punct ", ",dissected
R1957 T8286 T8282 nsubjpass lungs,dissected
R1958 T8287 T8282 auxpass were,dissected
R1959 T8288 T8282 prep from,dissected
R1960 T8289 T8290 nmod Fog2,mice
R1961 T8290 T8288 pobj mice,from
R1962 T8291 T8289 punct −,Fog2
R1963 T8292 T8289 punct /,Fog2
R1964 T8293 T8289 punct −,Fog2
R1965 T8294 T8290 cc and,mice
R1966 T8295 T8296 compound littermate,controls
R1967 T8296 T8290 conj controls,mice
R1968 T8297 T8282 prep before,dissected
R1969 T8298 T8299 det the,onset
R1970 T8299 T8297 pobj onset,before
R1971 T8300 T8299 prep of,onset
R1972 T8301 T8302 amod fetal,motion
R1973 T8302 T8300 pobj motion,of
R1974 T8303 T8302 amod diaphragmatic,motion
R1975 T8304 T8282 punct .,dissected
R1976 T8306 T8307 nmod Fog2,mice
R1977 T8307 T8311 nsubjpass mice,used
R1978 T8308 T8306 punct −,Fog2
R1979 T8309 T8306 punct /,Fog2
R1980 T8310 T8306 punct −,Fog2
R1981 T8312 T8311 auxpass were,used
R1982 T8313 T8311 prep for,used
R1983 T8314 T8315 det this,experiment
R1984 T8315 T8313 pobj experiment,for
R1985 T8316 T8311 punct ", ",used
R1986 T8317 T8318 mark as,wanted
R1987 T8318 T8311 advcl wanted,used
R1988 T8319 T8318 nsubj we,wanted
R1989 T8320 T8321 aux to,avoid
R1990 T8321 T8318 xcomp avoid,wanted
R1991 T8322 T8323 amod potential,variance
R1992 T8323 T8321 dobj variance,avoid
R1993 T8324 T8323 amod phenotypic,variance
R1994 T8325 T8323 prep from,variance
R1995 T8326 T8327 det the,mutation
R1996 T8327 T8325 pobj mutation,from
R1997 T8328 T8327 nmod lil,mutation
R1998 T8329 T8327 amod hypomorphic,mutation
R1999 T8330 T8311 punct .,used
R2000 T8332 T8333 nsubj Lungs,were
R2001 T8334 T8332 acl dissected,Lungs
R2002 T8335 T8334 prep at,dissected
R2003 T8336 T8335 pobj E12,at
R2004 T8337 T8332 prep from,Lungs
R2005 T8338 T8339 nmod Fog2,embryos
R2006 T8339 T8337 pobj embryos,from
R2007 T8340 T8338 punct −,Fog2
R2008 T8341 T8338 punct /,Fog2
R2009 T8342 T8338 punct −,Fog2
R2010 T8343 T8333 acomp smaller,were
R2011 T8344 T8343 prep in,smaller
R2012 T8345 T8344 pobj size,in
R2013 T8346 T8333 cc and,were
R2014 T8347 T8333 conj lacked,were
R2015 T8348 T8349 det the,development
R2016 T8349 T8347 dobj development,lacked
R2017 T8350 T8349 prep of,development
R2018 T8351 T8352 det an,lobe
R2019 T8352 T8350 pobj lobe,of
R2020 T8353 T8352 amod accessory,lobe
R2021 T8354 T8333 punct .,were
R2022 T8356 T8357 prep In,was
R2023 T8358 T8359 nummod 11,explants
R2024 T8359 T8356 pobj explants,In
R2025 T8360 T8359 amod viable,explants
R2026 T8361 T8359 nmod Fog2,explants
R2027 T8362 T8361 punct −,Fog2
R2028 T8363 T8361 punct /,Fog2
R2029 T8364 T8361 punct −,Fog2
R2030 T8365 T8366 compound lung,culture
R2031 T8366 T8359 compound culture,explants
R2032 T8367 T8357 punct ", ",was
R2033 T8368 T8357 expl there,was
R2034 T8369 T8357 neg never,was
R2035 T8370 T8357 attr development,was
R2036 T8371 T8370 prep of,development
R2037 T8372 T8373 det an,lobe
R2038 T8373 T8371 pobj lobe,of
R2039 T8374 T8373 amod accessory,lobe
R2040 T8375 T8357 punct ", ",was
R2041 T8376 T8357 cc and,was
R2042 T8377 T8378 det the,weights
R2043 T8378 T8379 nsubj weights,were
R2044 T8379 T8357 conj were,was
R2045 T8380 T8378 prep of,weights
R2046 T8381 T8382 compound mutant,lungs
R2047 T8382 T8380 pobj lungs,of
R2048 T8383 T8382 acl cultured,lungs
R2049 T8384 T8383 prep for,cultured
R2050 T8385 T8386 nummod 5,d
R2051 T8386 T8384 pobj d,for
R2052 T8387 T8388 advmod significantly,lower
R2053 T8388 T8379 acomp lower,were
R2054 T8389 T8388 prep than,lower
R2055 T8390 T8389 pobj those,than
R2056 T8391 T8390 prep of,those
R2057 T8392 T8393 compound littermate,controls
R2058 T8393 T8391 pobj controls,of
R2059 T8394 T8395 punct (,Figure
R2060 T8395 T8379 parataxis Figure,were
R2061 T8396 T8395 nummod 4,Figure
R2062 T8397 T8395 punct ),Figure
R2063 T8398 T8357 punct .,was
R2064 T8400 T8401 det These,data
R2065 T8401 T8402 nsubj data,demonstrate
R2066 T8403 T8404 mark that,is
R2067 T8404 T8402 ccomp is,demonstrate
R2068 T8405 T8406 det the,hypoplasia
R2069 T8406 T8404 nsubj hypoplasia,is
R2070 T8407 T8406 amod pulmonary,hypoplasia
R2071 T8408 T8406 prep in,hypoplasia
R2072 T8409 T8410 compound Fog2,mice
R2073 T8410 T8408 pobj mice,in
R2074 T8411 T8410 compound mutant,mice
R2075 T8412 T8413 det a,defect
R2076 T8413 T8404 attr defect,is
R2077 T8414 T8413 amod primary,defect
R2078 T8415 T8402 punct .,demonstrate
R2079 T8417 T8418 nsubj Branching,appeared
R2080 T8419 T8417 prep in,Branching
R2081 T8420 T8421 det the,lobes
R2082 T8421 T8419 pobj lobes,in
R2083 T8422 T8421 amod unaffected,lobes
R2084 T8423 T8424 aux to,delayed
R2085 T8424 T8418 xcomp delayed,appeared
R2086 T8425 T8424 auxpass be,delayed
R2087 T8426 T8424 prep by,delayed
R2088 T8427 T8428 quantmod 6,12
R2089 T8428 T8430 nummod 12,h
R2090 T8429 T8428 punct –,12
R2091 T8430 T8426 pobj h,by
R2092 T8431 T8418 punct ", ",appeared
R2093 T8432 T8418 cc but,appeared
R2094 T8433 T8434 det all,mutants
R2095 T8434 T8435 nsubj mutants,developed
R2096 T8435 T8418 conj developed,appeared
R2097 T8436 T8437 det an,pattern
R2098 T8437 T8435 dobj pattern,developed
R2099 T8438 T8437 amod intricate,pattern
R2100 T8439 T8437 compound branching,pattern
R2101 T8440 T8435 prep in,developed
R2102 T8441 T8442 det the,lobes
R2103 T8442 T8440 pobj lobes,in
R2104 T8443 T8442 amod unaffected,lobes
R2105 T8444 T8435 prep after,developed
R2106 T8445 T8444 pobj culture,after
R2107 T8446 T8445 prep for,culture
R2108 T8447 T8448 nummod 5,d
R2109 T8448 T8446 pobj d,for
R2110 T8449 T8435 punct .,developed
R2111 T8451 T8452 mark Because,is
R2112 T8452 T8456 advcl is,evaluated
R2113 T8453 T8454 det the,phenotype
R2114 T8454 T8452 nsubj phenotype,is
R2115 T8455 T8454 compound Fog2,phenotype
R2116 T8457 T8452 acomp striking,is
R2117 T8458 T8457 prep for,striking
R2118 T8459 T8460 amod specific,loss
R2119 T8460 T8458 pobj loss,for
R2120 T8461 T8460 compound lobar,loss
R2121 T8462 T8456 punct ", ",evaluated
R2122 T8463 T8464 det the,pattern
R2123 T8464 T8456 nsubjpass pattern,evaluated
R2124 T8465 T8464 amod spatial,pattern
R2125 T8466 T8464 prep of,pattern
R2126 T8467 T8468 compound Fog2,expression
R2127 T8468 T8466 pobj expression,of
R2128 T8469 T8456 auxpass was,evaluated
R2129 T8470 T8456 prep in,evaluated
R2130 T8471 T8472 amod normal,embryos
R2131 T8472 T8470 pobj embryos,in
R2132 T8473 T8456 prep during,evaluated
R2133 T8474 T8475 det the,period
R2134 T8475 T8473 pobj period,during
R2135 T8476 T8475 prep of,period
R2136 T8477 T8478 amod early,establishment
R2137 T8478 T8476 pobj establishment,of
R2138 T8479 T8478 compound lobar,establishment
R2139 T8480 T8481 aux to,determine
R2140 T8481 T8456 advcl determine,evaluated
R2141 T8482 T8483 mark whether,is
R2142 T8483 T8481 ccomp is,determine
R2143 T8484 T8485 compound Fog2,expression
R2144 T8485 T8483 nsubj expression,is
R2145 T8486 T8487 advmod specifically,different
R2146 T8487 T8483 acomp different,is
R2147 T8488 T8483 prep at,is
R2148 T8489 T8490 det these,buds
R2149 T8490 T8488 pobj buds,at
R2150 T8491 T8490 compound lobar,buds
R2151 T8492 T8456 punct .,evaluated
R2152 T8494 T8495 nsubjpass Expression,evaluated
R2153 T8496 T8495 auxpass was,evaluated
R2154 T8497 T8495 prep in,evaluated
R2155 T8498 T8497 pobj mice,in
R2156 T8499 T8498 acl carrying,mice
R2157 T8500 T8501 det a,gene
R2158 T8501 T8499 dobj gene,carrying
R2159 T8502 T8501 compound lacZ,gene
R2160 T8503 T8501 acl incorporated,gene
R2161 T8504 T8503 prep into,incorporated
R2162 T8505 T8506 det the,locus
R2163 T8506 T8504 pobj locus,into
R2164 T8507 T8506 compound Fog2,locus
R2165 T8508 T8509 punct (,S.
R2166 T8509 T8495 meta S.,evaluated
R2167 T8510 T8509 nmod Tevosian,S.
R2168 T8511 T8509 punct ", ",S.
R2169 T8512 T8509 amod unpublished,S.
R2170 T8513 T8509 nmod data,S.
R2171 T8514 T8509 punct ),S.
R2172 T8515 T8495 punct .,evaluated
R2173 T8517 T8518 prep In,showed
R2174 T8519 T8520 nummod nine,mice
R2175 T8520 T8517 pobj mice,In
R2176 T8521 T8520 acl examined,mice
R2177 T8522 T8521 prep at,examined
R2178 T8523 T8522 pobj E11.5,at
R2179 T8524 T8518 punct ", ",showed
R2180 T8525 T8526 det all,lungs
R2181 T8526 T8518 nsubj lungs,showed
R2182 T8527 T8528 det a,enhancement
R2183 T8528 T8518 dobj enhancement,showed
R2184 T8529 T8528 amod specific,enhancement
R2185 T8530 T8528 prep of,enhancement
R2186 T8531 T8532 compound Fog2,expression
R2187 T8532 T8530 pobj expression,of
R2188 T8533 T8518 prep in,showed
R2189 T8534 T8535 det the,mesenchyme
R2190 T8535 T8533 pobj mesenchyme,in
R2191 T8536 T8535 acl surrounding,mesenchyme
R2192 T8537 T8538 det the,bud
R2193 T8538 T8536 dobj bud,surrounding
R2194 T8539 T8538 amod accessory,bud
R2195 T8540 T8538 cc and,bud
R2196 T8541 T8542 det the,bud
R2197 T8542 T8538 conj bud,bud
R2198 T8543 T8542 amod right,bud
R2199 T8544 T8542 amod middle,bud
R2200 T8545 T8542 compound lobe,bud
R2201 T8546 T8538 punct ", ",bud
R2202 T8547 T8548 dep which,are
R2203 T8548 T8538 relcl are,bud
R2204 T8549 T8550 det the,lobes
R2205 T8550 T8548 attr lobes,are
R2206 T8551 T8552 dep that,develop
R2207 T8552 T8550 relcl develop,lobes
R2208 T8553 T8552 aux do,develop
R2209 T8554 T8552 neg not,develop
R2210 T8555 T8552 advmod normally,develop
R2211 T8556 T8552 prep in,develop
R2212 T8557 T8558 compound Fog2,mice
R2213 T8558 T8556 pobj mice,in
R2214 T8559 T8558 compound mutant,mice
R2215 T8560 T8561 punct (,Figure
R2216 T8561 T8518 parataxis Figure,showed
R2217 T8562 T8561 nummod 5,Figure
R2218 T8563 T8561 punct ),Figure
R2219 T8564 T8518 punct .,showed
R2220 T8566 T8567 prep By,was
R2221 T8568 T8566 pobj E12.5,By
R2222 T8569 T8567 punct ", ",was
R2223 T8570 T8567 nsubj expression,was
R2224 T8571 T8567 acomp diffuse,was
R2225 T8572 T8567 prep in,was
R2226 T8573 T8574 det the,mesenchyme
R2227 T8574 T8572 pobj mesenchyme,in
R2228 T8575 T8574 amod pulmonary,mesenchyme
R2229 T8576 T8567 punct ", ",was
R2230 T8577 T8578 mark as,seen
R2231 T8578 T8567 advcl seen,was
R2232 T8579 T8578 auxpass was,seen
R2233 T8580 T8578 advmod previously,seen
R2234 T8581 T8578 prep with,seen
R2235 T8582 T8583 advmod in,situ
R2236 T8583 T8584 amod situ,hybridization
R2237 T8584 T8581 pobj hybridization,with
R2238 T8585 T8584 prep on,hybridization
R2239 T8586 T8587 compound tissue,sections
R2240 T8587 T8585 pobj sections,on
R2241 T8588 T8567 punct .,was
R2242 T8590 T8591 nsubj Diaphragms,show
R2243 T8592 T8590 prep from,Diaphragms
R2244 T8593 T8594 compound Fog2,mice
R2245 T8594 T8592 pobj mice,from
R2246 T8595 T8594 compound lil,mice
R2247 T8596 T8597 det an,membrane
R2248 T8597 T8591 dobj membrane,show
R2249 T8598 T8597 amod intact,membrane
R2250 T8599 T8597 prep with,membrane
R2251 T8600 T8601 det a,defect
R2252 T8601 T8599 pobj defect,with
R2253 T8602 T8601 prep in,defect
R2254 T8603 T8604 amod muscular,patterning
R2255 T8604 T8602 pobj patterning,in
R2256 T8605 T8606 punct (,see
R2257 T8606 T8591 parataxis see,show
R2258 T8607 T8606 dobj Figure,see
R2259 T8608 T8607 nummod 1B,Figure
R2260 T8609 T8606 punct ),see
R2261 T8610 T8591 punct .,show
R2262 T8612 T8613 det The,portion
R2263 T8613 T8615 nsubjpass portion,populated
R2264 T8614 T8613 amod membranous,portion
R2265 T8658 T8656 cc but,intact
R2266 T8659 T8656 conj amuscular,intact
R2267 T8616 T8613 prep of,portion
R2268 T8660 T8661 punct [,22
R2269 T8661 T8641 parataxis 22,have
R2270 T8662 T8661 nummod 17,22
R2271 T8617 T8618 det the,diaphragm
R2272 T8663 T8661 punct ",",22
R2273 T8664 T8661 nummod 21,22
R2274 T8665 T8661 punct ",",22
R2275 T8618 T8616 pobj diaphragm,of
R2276 T8666 T8661 punct ],22
R2277 T8667 T8641 punct .,have
R2278 T8619 T8615 auxpass is,populated
R2279 T8669 T8670 compound Hepatocyte,factor
R2280 T8670 T8672 nsubj factor,is
R2281 T8620 T8615 agent by,populated
R2282 T8671 T8670 compound growth,factor
R2283 T8673 T8670 punct /,factor
R2284 T8621 T8622 det a,population
R2285 T8674 T8675 compound Scatter,factor
R2286 T8675 T8670 appos factor,factor
R2287 T8676 T8670 punct (,factor
R2288 T8622 T8620 pobj population,by
R2289 T8677 T8670 appos HGF,factor
R2290 T8678 T8672 punct ),is
R2291 T8679 T8680 nummod one,candidate
R2292 T8623 T8622 amod migratory,population
R2293 T8680 T8672 attr candidate,is
R2294 T8681 T8680 amod potential,candidate
R2295 T8624 T8622 prep of,population
R2296 T8682 T8680 amod responsible,candidate
R2297 T8683 T8682 prep for,responsible
R2298 T8684 T8685 det the,guidance
R2299 T8625 T8626 compound muscle,cells
R2300 T8685 T8683 pobj guidance,for
R2301 T8686 T8685 prep of,guidance
R2302 T8687 T8688 compound muscle,precursors
R2303 T8626 T8624 pobj cells,of
R2304 T8688 T8686 pobj precursors,of
R2305 T8689 T8688 prep to,precursors
R2306 T8627 T8626 compound precursor,cells
R2307 T8690 T8691 det the,diaphragm
R2308 T8691 T8689 pobj diaphragm,to
R2309 T8692 T8691 amod membranous,diaphragm
R2310 T8628 T8615 punct ", ",populated
R2311 T8693 T8672 punct .,is
R2312 T8629 T8630 advmod much,like
R2313 T8695 T8696 nsubjpass It,shown
R2314 T8697 T8696 aux has,shown
R2315 T8630 T8615 prep like,populated
R2316 T8698 T8696 auxpass been,shown
R2317 T8631 T8632 det the,limbs
R2318 T8699 T8700 mark that,expressed
R2319 T8700 T8696 ccomp expressed,shown
R2320 T8701 T8700 nsubjpass HGF,expressed
R2321 T8702 T8700 auxpass is,expressed
R2322 T8632 T8630 pobj limbs,like
R2323 T8703 T8700 prep along,expressed
R2324 T8704 T8705 det this,pathway
R2325 T8633 T8634 punct [,20
R2326 T8705 T8703 pobj pathway,along
R2327 T8706 T8705 amod anatomic,pathway
R2328 T8707 T8708 punct [,23
R2329 T8634 T8615 parataxis 20,populated
R2330 T8708 T8696 parataxis 23,shown
R2331 T8709 T8708 punct ],23
R2332 T8635 T8634 nummod 19,20
R2333 T8710 T8696 punct ", ",shown
R2334 T8711 T8696 cc and,shown
R2335 T8712 T8713 nsubj mice,fail
R2336 T8636 T8634 punct ",",20
R2337 T8713 T8696 conj fail,shown
R2338 T8714 T8712 prep with,mice
R2339 T8637 T8634 punct ],20
R2340 T8715 T8714 pobj absence,with
R2341 T8716 T8715 prep of,absence
R2342 T8717 T8718 det the,receptor
R2343 T8638 T8615 punct .,populated
R2344 T8718 T8716 pobj receptor,of
R2345 T8719 T8718 compound HGF,receptor
R2346 T8720 T8721 compound c,Met
R2347 T8640 T8641 nsubj Mice,have
R2348 T8721 T8718 appos Met,receptor
R2349 T8722 T8721 punct -,Met
R2350 T8723 T8724 aux to,form
R2351 T8724 T8713 xcomp form,fail
R2352 T8725 T8726 amod muscularized,folds
R2353 T8642 T8640 prep with,Mice
R2354 T8726 T8724 dobj folds,form
R2355 T8727 T8726 amod pleuroperitoneal,folds
R2356 T8728 T8726 punct (,folds
R2357 T8729 T8726 appos PPFs,folds
R2358 T8643 T8642 pobj defects,with
R2359 T8730 T8713 punct ),fail
R2360 T8644 T8643 prep in,defects
R2361 T8731 T8713 punct ", ",fail
R2362 T8732 T8713 cc and,fail
R2363 T8733 T8734 advmod thus,have
R2364 T8645 T8644 pobj genes,in
R2365 T8734 T8713 conj have,fail
R2366 T8735 T8736 amod amuscular,diaphragms
R2367 T8736 T8734 dobj diaphragms,have
R2368 T8646 T8645 acl known,genes
R2369 T8737 T8738 punct [,25
R2370 T8738 T8734 parataxis 25,have
R2371 T8739 T8738 nummod 24,25
R2372 T8740 T8738 punct ",",25
R2373 T8741 T8738 punct ],25
R2374 T8742 T8713 punct .,fail
R2375 T8647 T8648 aux to,be
R2376 T8744 T8745 nsubjpass Fog2,expressed
R2377 T8746 T8745 auxpass is,expressed
R2378 T8648 T8646 xcomp be,known
R2379 T8747 T8745 advmod diffusely,expressed
R2380 T8748 T8745 prep in,expressed
R2381 T8649 T8648 acomp important,be
R2382 T8650 T8649 prep for,important
R2383 T8749 T8750 det the,diaphragm
R2384 T8651 T8652 det the,control
R2385 T8750 T8748 pobj diaphragm,in
R2386 T8751 T8750 amod early,diaphragm
R2387 T8652 T8650 pobj control,for
R2388 T8752 T8750 amod amuscular,diaphragm
R2389 T8753 T8750 prep at,diaphragm
R2390 T8653 T8652 prep of,control
R2391 T8754 T8753 pobj E11.5,at
R2392 T8755 T8756 advmod as,as
R2393 T8756 T8748 cc as,in
R2394 T8654 T8655 det this,process
R2395 T8757 T8756 advmod well,as
R2396 T8758 T8748 conj in,in
R2397 T8759 T8760 det the,diaphragm
R2398 T8655 T8653 pobj process,of
R2399 T8760 T8758 pobj diaphragm,in
R2400 T8761 T8760 amod later,diaphragm
R2401 T8762 T8760 amod muscularized,diaphragm
R2402 T8656 T8657 amod intact,diaphragms
R2403 T8657 T8641 dobj diaphragms,have
R2404 T8869 T8867 pobj path,along
R2405 T8763 T8764 punct (,see
R2406 T8870 T8869 prep of,path
R2407 T8764 T8745 parataxis see,expressed
R2408 T8765 T8766 nmod Figure,3C
R2409 T8871 T8872 compound muscle,cell
R2410 T8766 T8764 dobj 3C,see
R2411 T8767 T8766 cc and,3C
R2412 T8768 T8766 conj 3D,3C
R2413 T8872 T8874 compound cell,migration
R2414 T8769 T8764 punct ),see
R2415 T8770 T8745 punct .,expressed
R2416 T8873 T8872 compound precursor,cell
R2417 T8772 T8773 nsubjpass Pax3,detected
R2418 T8874 T8870 pobj migration,of
R2419 T8774 T8772 cc and,Pax3
R2420 T8775 T8772 conj MyoD,Pax3
R2421 T8776 T8772 punct ", ",Pax3
R2422 T8777 T8778 compound transcription,factors
R2423 T8778 T8772 appos factors,Pax3
R2424 T8779 T8778 acl required,factors
R2425 T8875 T8869 prep between,path
R2426 T8780 T8779 prep for,required
R2427 T8781 T8782 amod appropriate,migration
R2428 T8782 T8780 pobj migration,for
R2429 T8783 T8782 cc and,migration
R2430 T8876 T8877 det the,PPF
R2431 T8877 T8875 pobj PPF,between
R2432 T8784 T8782 conj determination,migration
R2433 T8878 T8877 cc and,PPF
R2434 T8785 T8782 prep of,migration
R2435 T8786 T8787 amod myogenic,precursors
R2436 T8787 T8785 pobj precursors,of
R2437 T8879 T8880 det the,diaphragm
R2438 T8788 T8773 punct ", ",detected
R2439 T8789 T8773 auxpass were,detected
R2440 T8790 T8773 prep in,detected
R2441 T8880 T8877 conj diaphragm,PPF
R2442 T8791 T8792 det the,PPFs
R2443 T8792 T8790 pobj PPFs,in
R2444 T8881 T8863 prep for,accounts
R2445 T8793 T8792 prep of,PPFs
R2446 T8794 T8795 compound Fog2,mice
R2447 T8795 T8793 pobj mice,of
R2448 T8796 T8795 compound lil,mice
R2449 T8882 T8883 det the,phenotype
R2450 T8797 T8798 punct (,shown
R2451 T8798 T8773 parataxis shown,detected
R2452 T8799 T8798 nsubj data,shown
R2453 T8883 T8881 pobj phenotype,for
R2454 T8800 T8798 neg not,shown
R2455 T8801 T8798 punct ),shown
R2456 T8884 T8883 amod abnormal,phenotype
R2457 T8802 T8773 punct .,detected
R2458 T8804 T8805 advmod However,demonstrated
R2459 T8885 T8863 prep in,accounts
R2460 T8806 T8805 punct ", ",demonstrated
R2461 T8807 T8808 advmod in,situ
R2462 T8886 T8887 det these,mice
R2463 T8808 T8809 amod situ,analysis
R2464 T8809 T8805 nsubj analysis,demonstrated
R2465 T8810 T8809 compound expression,analysis
R2466 T8887 T8885 pobj mice,in
R2467 T8811 T8812 mark that,reduced
R2468 T8812 T8805 ccomp reduced,demonstrated
R2469 T8813 T8814 det the,expression
R2470 T8888 T8863 punct .,accounts
R2471 T8814 T8812 nsubjpass expression,reduced
R2472 T8815 T8814 prep of,expression
R2473 T8816 T8815 pobj HGF,of
R2474 T8817 T8814 prep in,expression
R2475 T8818 T8819 det the,region
R2476 T8819 T8817 pobj region,in
R2477 T8820 T8821 advmod where,meets
R2478 T8821 T8819 relcl meets,region
R2479 T8822 T8823 det this,structure
R2480 T8823 T8821 nsubj structure,meets
R2481 T8824 T8825 det the,diaphragm
R2482 T8825 T8821 dobj diaphragm,meets
R2483 T8826 T8825 amod membranous,diaphragm
R2484 T8827 T8812 auxpass was,reduced
R2485 T8828 T8812 advmod markedly,reduced
R2486 T8829 T8812 prep in,reduced
R2487 T8830 T8831 compound Fog2,mice
R2488 T8831 T8829 pobj mice,in
R2489 T8832 T8831 compound mutant,mice
R2490 T8833 T8834 punct (,Figure
R2491 T8834 T8805 parataxis Figure,demonstrated
R2492 T8835 T8834 nummod 6,Figure
R2493 T8836 T8834 punct ),Figure
R2494 T8837 T8805 punct .,demonstrated
R2495 T8839 T8840 nsubj We,hypothesize
R2496 T8841 T8842 mark that,required
R2497 T8842 T8840 ccomp required,hypothesize
R2498 T8843 T8842 nsubjpass Fog2,required
R2499 T8844 T8842 auxpass is,required
R2500 T8845 T8842 punct (,required
R2501 T8846 T8847 preconj either,directly
R2502 T8847 T8842 advmod directly,required
R2503 T8848 T8847 cc or,directly
R2504 T8849 T8847 conj indirectly,directly
R2505 T8850 T8842 punct ),required
R2506 T8851 T8842 prep for,required
R2507 T8852 T8853 det the,induction
R2508 T8853 T8851 pobj induction,for
R2509 T8854 T8853 prep of,induction
R2510 T8855 T8854 pobj HGF,of
R2511 T8856 T8853 prep in,induction
R2512 T8857 T8858 det the,diaphragm
R2513 T8858 T8856 pobj diaphragm,in
R2514 T8859 T8858 amod developing,diaphragm
R2515 T8860 T8840 punct ", ",hypothesize
R2516 T8861 T8840 cc and,hypothesize
R2517 T8862 T8863 nsubj dysregulation,accounts
R2518 T8863 T8840 conj accounts,hypothesize
R2519 T8864 T8862 prep of,dysregulation
R2520 T8865 T8866 compound HGF,patterning
R2521 T8866 T8864 pobj patterning,of
R2522 T8867 T8866 prep along,patterning
R2523 T8868 T8869 det the,path
R2526 T9907 T9908 compound FOG2,Mutation
R2527 T9909 T9908 prep in,Mutation
R2528 T9910 T9911 det a,Patient
R2529 T9911 T9909 pobj Patient,in
R2530 T9912 T9911 prep with,Patient
R2531 T9913 T9914 nmod Diaphragm,Abnormalities
R2532 T9914 T9912 pobj Abnormalities,with
R2533 T9915 T9913 cc and,Diaphragm
R2534 T9916 T9913 conj Lung,Diaphragm
R2535 T9918 T9919 compound FOG2,analysis
R2536 T9919 T9921 nsubjpass analysis,performed
R2537 T9920 T9919 compound sequence,analysis
R2538 T9922 T9921 auxpass was,performed
R2539 T9923 T9921 prep on,performed
R2540 T9924 T9925 compound autopsy,tissue
R2541 T9925 T9923 pobj tissue,on
R2542 T9926 T9925 prep from,tissue
R2543 T9927 T9928 quantmod 30,32
R2544 T9928 T9930 nummod 32,children
R2545 T9929 T9928 quantmod of,32
R2546 T9930 T9926 pobj children,from
R2547 T9931 T9930 amod deceased,children
R2548 T9932 T9930 prep with,children
R2549 T9933 T9934 det an,diagnosis
R2550 T9934 T9932 pobj diagnosis,with
R2551 T9935 T9934 amod anatomic,diagnosis
R2552 T9936 T9934 prep of,diagnosis
R2553 T9937 T9938 amod diaphragmatic,defect
R2554 T9938 T9936 pobj defect,of
R2555 T9939 T9925 acl evaluated,tissue
R2556 T9940 T9939 prep at,evaluated
R2557 T9941 T9942 det the,Hospital
R2558 T9942 T9940 pobj Hospital,at
R2559 T9943 T9942 poss Children,Hospital
R2560 T9944 T9943 case 's,Children
R2561 T9945 T9942 prep in,Hospital
R2562 T9946 T9945 pobj Boston,in
R2563 T9947 T9946 punct ", ",Boston
R2564 T9948 T9946 npadvmod Massachusetts,Boston
R2565 T9949 T9939 punct ", ",evaluated
R2566 T9950 T9939 prep between,evaluated
R2567 T9951 T9950 pobj 1993,between
R2568 T9952 T9951 cc and,1993
R2569 T9953 T9951 conj 2003,1993
R2570 T9954 T9921 punct .,performed
R2571 T9956 T9957 compound Autopsy,reports
R2572 T9957 T9958 nsubjpass reports,reviewed
R2573 T9959 T9958 auxpass were,reviewed
R2574 T9960 T9961 aux to,determine
R2575 T9961 T9958 advcl determine,reviewed
R2576 T9962 T9963 det the,diagnoses
R2577 T9963 T9961 dobj diagnoses,determine
R2578 T9964 T9963 amod specific,diagnoses
R2579 T9965 T9958 punct .,reviewed
R2580 T9967 T9968 prep Of,had
R2581 T9969 T9970 det these,cases
R2582 T9970 T9967 pobj cases,Of
R2583 T9971 T9970 nummod 30,cases
R2584 T9972 T9968 punct ", ",had
R2585 T9973 T9968 nsubj 17,had
R2586 T9974 T9975 punct (,%
R2587 T9975 T9973 parataxis %,17
R2588 T9976 T9975 nummod 57,%
R2589 T9977 T9975 punct ),%
R2590 T9978 T9979 compound Bochdalek,CDH
R2591 T9979 T9968 dobj CDH,had
R2592 T9980 T9968 punct ", ",had
R2593 T9981 T9982 nsubj two,had
R2594 T9982 T9968 conj had,had
R2595 T9983 T9984 punct (,%
R2596 T9984 T9981 parataxis %,two
R2597 T9985 T9984 nummod 7,%
R2598 T9986 T9984 punct ),%
R2599 T9987 T9988 amod diaphragmatic,agenesis
R2600 T9988 T9982 dobj agenesis,had
R2601 T9989 T9982 punct ", ",had
R2602 T9990 T9991 nsubj seven,had
R2603 T9991 T9982 conj had,had
R2604 T9992 T9993 punct (,%
R2605 T9993 T9990 parataxis %,seven
R2606 T9994 T9993 nummod 23,%
R2607 T9995 T9993 punct ),%
R2608 T9996 T9997 amod diaphragmatic,eventration
R2609 T9997 T9991 dobj eventration,had
R2610 T9998 T9997 punct /,eventration
R2611 T9999 T10000 compound muscularization,defects
R2612 T10000 T9997 appos defects,eventration
R2613 T10001 T9997 punct (,eventration
R2614 T10002 T9997 prep without,eventration
R2615 T10003 T10004 compound Bochdalek,CDH
R2616 T10004 T10002 pobj CDH,without
R2617 T10005 T9991 punct ),had
R2618 T10006 T9991 punct ", ",had
R2619 T10007 T9991 cc and,had
R2620 T10008 T10009 nsubj four,had
R2621 T10009 T9991 conj had,had
R2622 T10010 T10011 punct (,%
R2623 T10011 T10008 parataxis %,four
R2624 T10012 T10011 nummod 13,%
R2625 T10013 T10011 punct ),%
R2626 T10014 T10015 compound Bochdalek,hernia
R2627 T10015 T10009 dobj hernia,had
R2628 T10016 T10015 prep of,hernia
R2629 T10017 T10018 nummod one,hemidiaphragm
R2630 T10018 T10016 pobj hemidiaphragm,of
R2631 T10019 T10015 cc and,hernia
R2632 T10020 T10015 conj eventration,hernia
R2633 T10021 T10020 prep of,eventration
R2634 T10022 T10023 det the,other
R2635 T10023 T10021 pobj other,of
R2636 T10024 T10009 punct .,had
R2637 T10026 T10027 amod Pulmonary,hypoplasia
R2638 T10027 T10028 nsubjpass hypoplasia,assessed
R2639 T10029 T10028 auxpass was,assessed
R2640 T10030 T10028 advcl using,assessed
R2641 T10031 T10032 compound lung,body
R2642 T10032 T10034 compound body,ratio
R2643 T10033 T10032 punct /,body
R2644 T10034 T10030 dobj ratio,using
R2645 T10035 T10034 compound weight,ratio
R2646 T10036 T10034 cc and,ratio
R2647 T10037 T10038 amod radial,counts
R2648 T10038 T10034 conj counts,ratio
R2649 T10039 T10038 amod alveolar,counts
R2650 T10040 T10041 punct [,26
R2651 T10041 T10028 parataxis 26,assessed
R2652 T10042 T10041 punct ],26
R2653 T10043 T10028 punct .,assessed
R2654 T10045 T10046 det The,material
R2655 T10046 T10047 nsubj material,included
R2656 T10048 T10046 amod available,material
R2657 T10049 T10048 prep for,available
R2658 T10050 T10049 pobj review,for
R2659 T10051 T10052 amod written,reports
R2660 T10052 T10047 dobj reports,included
R2661 T10053 T10052 cc and,reports
R2662 T10054 T10055 amod histologic,slides
R2663 T10055 T10052 conj slides,reports
R2664 T10056 T10047 prep in,included
R2665 T10057 T10058 det all,cases
R2666 T10058 T10056 pobj cases,in
R2667 T10059 T10047 cc and,included
R2668 T10060 T10061 amod gross,kodachromes
R2669 T10061 T10047 conj kodachromes,included
R2670 T10062 T10061 prep in,kodachromes
R2671 T10063 T10064 det a,subset
R2672 T10064 T10062 pobj subset,in
R2673 T10065 T10064 prep of,subset
R2674 T10066 T10065 pobj cases,of
R2675 T10067 T10047 punct .,included
R2676 T10069 T10070 nummod One,child
R2677 T10070 T10071 nsubj child,carried
R2678 T10072 T10073 det a,change
R2679 T10073 T10071 dobj change,carried
R2680 T10074 T10075 advmod highly,significant
R2681 T10075 T10073 amod significant,change
R2682 T10076 T10073 compound FOG2,change
R2683 T10077 T10073 compound sequence,change
R2684 T10078 T10071 punct .,carried
R2685 T10080 T10081 det The,patient
R2686 T10081 T10082 nsubj patient,was
R2687 T10083 T10084 det a,girl
R2688 T10084 T10082 attr girl,was
R2689 T10085 T10086 amod full,term
R2690 T10086 T10084 nmod term,girl
R2691 T10087 T10086 punct -,term
R2692 T10088 T10089 nummod "3,500",g
R2693 T10089 T10084 compound g,girl
R2694 T10090 T10089 punct -,g
R2695 T10091 T10084 compound baby,girl
R2696 T10092 T10093 dep who,developed
R2697 T10093 T10084 relcl developed,girl
R2698 T10094 T10095 amod severe,failure
R2699 T10095 T10093 dobj failure,developed
R2700 T10096 T10095 amod respiratory,failure
R2701 T10097 T10093 prep at,developed
R2702 T10098 T10097 pobj birth,at
R2703 T10099 T10093 cc and,developed
R2704 T10100 T10093 conj died,developed
R2705 T10101 T10100 prep after,died
R2706 T10102 T10103 nummod 5,h
R2707 T10103 T10101 pobj h,after
R2708 T10104 T10103 prep of,h
R2709 T10105 T10104 pobj resuscitation,of
R2710 T10106 T10082 punct .,was
R2711 T10108 T10109 compound Antemortem,radiographs
R2712 T10109 T10110 nsubj radiographs,showed
R2713 T10111 T10112 amod opacified,fields
R2714 T10112 T10110 dobj fields,showed
R2715 T10113 T10112 compound lung,fields
R2716 T10114 T10112 cc and,fields
R2717 T10115 T10116 amod possible,bowel
R2718 T10116 T10112 conj bowel,fields
R2719 T10117 T10116 prep in,bowel
R2720 T10118 T10119 det the,chest
R2721 T10119 T10117 pobj chest,in
R2722 T10120 T10110 punct .,showed
R2723 T10122 T10123 det The,patient
R2724 T10123 T10124 poss patient,diagnosis
R2725 T10124 T10127 nsubj diagnosis,was
R2726 T10125 T10123 case 's,patient
R2727 T10126 T10124 amod clinical,diagnosis
R2728 T10128 T10127 attr CDH,was
R2729 T10129 T10127 punct .,was
R2730 T10131 T10132 nsubj Review,revealed
R2731 T10133 T10131 prep of,Review
R2732 T10134 T10135 compound autopsy,material
R2733 T10135 T10133 pobj material,of
R2734 T10136 T10137 amod severe,hypoplasia
R2735 T10137 T10132 dobj hypoplasia,revealed
R2736 T10138 T10137 amod bilateral,hypoplasia
R2737 T10139 T10137 amod pulmonary,hypoplasia
R2738 T10140 T10141 punct (,27
R2739 T10141 T10137 parataxis 27,hypoplasia
R2740 T10142 T10143 amod combined,weight
R2741 T10143 T10145 dep weight,g
R2742 T10144 T10143 compound lung,weight
R2743 T10145 T10141 dep g,27
R2744 T10146 T10145 punct ", ",g
R2745 T10147 T10145 nummod 11.1,g
R2746 T10148 T10141 punct ;,27
R2747 T10149 T10141 dep expected,27
R2748 T10150 T10149 prep for,expected
R2749 T10151 T10152 compound body,weight
R2750 T10152 T10150 pobj weight,for
R2751 T10153 T10152 compound length,weight
R2752 T10154 T10152 punct /,weight
R2753 T10155 T10149 punct ", ",expected
R2754 T10156 T10157 quantmod 46.8,26.2
R2755 T10157 T10159 nummod 26.2,g
R2756 T10158 T10157 punct ±,26.2
R2757 T10159 T10149 dep g,expected
R2758 T10160 T10141 punct ;,27
R2759 T10161 T10141 punct [,27
R2760 T10162 T10141 punct ],27
R2761 T10163 T10141 punct ),27
R2762 T10164 T10137 punct ", ",hypoplasia
R2763 T10165 T10166 advmod most,markedly
R2764 T10166 T10167 advmod markedly,involving
R2765 T10167 T10137 acl involving,hypoplasia
R2766 T10168 T10169 det the,lung
R2767 T10169 T10167 dobj lung,involving
R2768 T10170 T10169 amod left,lung
R2769 T10171 T10132 punct .,revealed
R2770 T10173 T10174 det The,ratio
R2771 T10174 T10179 nsubj ratio,was
R2772 T10175 T10174 nmod lung,ratio
R2773 T10176 T10177 punct /,body
R2774 T10177 T10175 prep body,lung
R2775 T10178 T10174 compound weight,ratio
R2776 T10180 T10179 attr 0.0037,was
R2777 T10181 T10182 punct (,0.010
R2778 T10182 T10179 parataxis 0.010,was
R2779 T10183 T10182 nsubj expected,0.010
R2780 T10184 T10182 punct >,0.010
R2781 T10185 T10182 punct ),0.010
R2782 T10186 T10187 punct [,28
R2783 T10187 T10179 parataxis 28,was
R2784 T10188 T10187 punct ],28
R2785 T10189 T10179 punct .,was
R2786 T10191 T10192 expl There,were
R2787 T10193 T10194 det a,number
R2788 T10194 T10192 attr number,were
R2789 T10195 T10194 amod reduced,number
R2790 T10196 T10194 prep of,number
R2791 T10197 T10198 amod bronchial,generations
R2792 T10198 T10196 pobj generations,of
R2793 T10199 T10192 punct ", ",were
R2794 T10200 T10192 cc and,were
R2795 T10201 T10202 det the,count
R2796 T10202 T10205 nsubj count,was
R2797 T10203 T10202 amod radial,count
R2798 T10204 T10202 amod alveolar,count
R2799 T10205 T10192 conj was,were
R2800 T10206 T10207 quantmod 2,3
R2801 T10207 T10205 attr 3,was
R2802 T10208 T10207 punct –,3
R2803 T10209 T10210 punct (,5
R2804 T10210 T10205 parataxis 5,was
R2805 T10211 T10210 nsubj expected,5
R2806 T10212 T10210 punct =,5
R2807 T10213 T10210 punct ),5
R2808 T10214 T10215 punct [,29
R2809 T10215 T10205 parataxis 29,was
R2810 T10216 T10215 punct ],29
R2811 T10217 T10205 punct .,was
R2812 T10219 T10220 expl There,were
R2813 T10221 T10222 amod incomplete,fissures
R2814 T10222 T10220 attr fissures,were
R2815 T10223 T10222 compound lung,fissures
R2816 T10224 T10220 advmod bilaterally,were
R2817 T10225 T10220 punct .,were
R2818 T10227 T10228 det A,eventration
R2819 T10228 T10232 nsubj eventration,was
R2820 T10229 T10228 amod deep,eventration
R2821 T10230 T10228 amod posterior,eventration
R2822 T10231 T10228 amod diaphragmatic,eventration
R2823 T10233 T10232 acomp present,was
R2824 T10234 T10232 prep on,was
R2825 T10235 T10236 det the,side
R2826 T10236 T10234 pobj side,on
R2827 T10237 T10236 amod left,side
R2828 T10238 T10232 punct .,was
R2829 T10240 T10241 advmod Additionally,encircled
R2830 T10242 T10241 punct ", ",encircled
R2831 T10243 T10244 nummod two,bands
R2832 T10244 T10241 nsubj bands,encircled
R2833 T10245 T10244 amod muscularized,bands
R2834 T10246 T10244 amod ligamentous,bands
R2835 T10247 T10244 acl resembling,bands
R2836 T10248 T10249 amod diaphragmatic,remnants
R2837 T10249 T10247 dobj remnants,resembling
R2838 T10250 T10251 det the,lobe
R2839 T10251 T10241 dobj lobe,encircled
R2840 T10252 T10251 amod left,lobe
R2841 T10253 T10251 prep of,lobe
R2842 T10254 T10255 det the,liver
R2843 T10255 T10253 pobj liver,of
R2844 T10256 T10241 punct ", ",encircled
R2845 T10257 T10241 advcl creating,encircled
R2846 T10258 T10259 det an,contour
R2847 T10259 T10257 dobj contour,creating
R2848 T10260 T10259 amod abnormal,contour
R2849 T10261 T10259 amod fissured,contour
R2850 T10262 T10259 compound liver,contour
R2851 T10263 T10241 punct .,encircled
R2852 T10265 T10266 advmod Away,appeared
R2853 T10267 T10265 prep from,Away
R2854 T10268 T10269 det the,eventration
R2855 T10269 T10267 pobj eventration,from
R2856 T10270 T10266 punct ", ",appeared
R2857 T10271 T10272 det the,diaphragm
R2858 T10272 T10266 nsubj diaphragm,appeared
R2859 T10273 T10274 advmod well,muscularized
R2860 T10274 T10266 oprd muscularized,appeared
R2861 T10275 T10266 punct ", ",appeared
R2862 T10276 T10266 advcl measuring,appeared
R2863 T10277 T10278 nummod 0.3,cm
R2864 T10278 T10276 dobj cm,measuring
R2865 T10279 T10278 prep in,cm
R2866 T10280 T10279 pobj thickness,in
R2867 T10281 T10266 punct .,appeared
R2868 T10283 T10284 det A,autopsy
R2869 T10284 T10286 nsubj autopsy,revealed
R2870 T10285 T10284 amod complete,autopsy
R2871 T10286 T10287 ccomp revealed,determined
R2872 T10288 T10289 det no,malformations
R2873 T10289 T10286 dobj malformations,revealed
R2874 T10290 T10289 amod other,malformations
R2875 T10291 T10287 punct ;,determined
R2876 T10292 T10293 det the,heart
R2877 T10293 T10287 nsubjpass heart,determined
R2878 T10294 T10287 auxpass was,determined
R2879 T10295 T10296 aux to,be
R2880 T10296 T10287 xcomp be,determined
R2881 T10297 T10298 advmod grossly,normal
R2882 T10298 T10296 acomp normal,be
R2883 T10299 T10287 cc and,determined
R2884 T10300 T10301 auxpass was,donated
R2885 T10301 T10287 conj donated,determined
R2886 T10302 T10301 prep for,donated
R2887 T10303 T10304 compound valve,harvest
R2888 T10304 T10302 pobj harvest,for
R2889 T10305 T10287 punct .,determined
R2890 T10307 T10308 compound Sequence,analysis
R2891 T10308 T10309 nsubj analysis,revealed
R2892 T10310 T10311 det a,change
R2893 T10311 T10309 dobj change,revealed
R2894 T10312 T10311 nmod cytosine,change
R2895 T10313 T10312 prep to,cytosine
R2896 T10314 T10313 pobj thymine,to
R2897 T10315 T10311 amod heterozygous,change
R2898 T10316 T10311 prep in,change
R2899 T10317 T10316 pobj exon,in
R2900 T10318 T10317 nummod 4,exon
R2901 T10319 T10320 dep that,changes
R2902 T10320 T10311 relcl changes,change
R2903 T10321 T10322 det the,acid
R2904 T10322 T10320 dobj acid,changes
R2905 T10323 T10322 amod 112th,acid
R2906 T10324 T10322 compound amino,acid
R2907 T10325 T10320 prep from,changes
R2908 T10326 T10325 pobj arginine,from
R2909 T10327 T10320 prep to,changes
R2910 T10328 T10329 det a,codon
R2911 T10329 T10327 pobj codon,to
R2912 T10330 T10329 compound stop,codon
R2913 T10331 T10309 punct .,revealed
R2914 T10333 T10334 det This,mutation
R2915 T10334 T10335 nsubj mutation,produces
R2916 T10336 T10337 det a,peptide
R2917 T10337 T10335 dobj peptide,produces
R2918 T10338 T10339 advmod severely,truncated
R2919 T10339 T10337 amod truncated,peptide
R2920 T10340 T10341 dep that,contain
R2921 T10341 T10337 relcl contain,peptide
R2922 T10342 T10341 aux does,contain
R2923 T10343 T10341 neg not,contain
R2924 T10344 T10345 compound zinc,finger
R2925 T10345 T10346 compound finger,domains
R2926 T10346 T10341 dobj domains,contain
R2927 T10347 T10348 punct (,Figure
R2928 T10348 T10335 parataxis Figure,produces
R2929 T10349 T10348 nummod 7,Figure
R2930 T10350 T10348 punct ),Figure
R2931 T10351 T10335 punct .,produces
R2932 T10353 T10354 det This,change
R2933 T10354 T10356 nsubj change,was
R2934 T10355 T10354 compound base,change
R2935 T10357 T10356 neg not,was
R2936 T10358 T10356 acomp present,was
R2937 T10359 T10356 prep in,was
R2938 T10360 T10361 det the,analysis
R2939 T10361 T10359 pobj analysis,in
R2940 T10362 T10361 prep of,analysis
R2941 T10363 T10362 pobj DNA,of
R2942 T10364 T10363 prep from,DNA
R2943 T10365 T10366 nummod 400,adults
R2944 T10366 T10364 pobj adults,from
R2945 T10367 T10366 amod normal,adults
R2946 T10368 T10356 punct .,was
R2947 T10370 T10371 aux To,assess
R2948 T10371 T10372 advcl assess,examined
R2949 T10373 T10374 det the,likelihood
R2950 T10374 T10371 dobj likelihood,assess
R2951 T10375 T10376 mark that,was
R2952 T10376 T10374 acl was,likelihood
R2953 T10377 T10378 det the,mutation
R2954 T10378 T10376 nsubj mutation,was
R2955 T10379 T10376 acomp causal,was
R2956 T10380 T10379 prep for,causal
R2957 T10381 T10382 det the,phenotype
R2958 T10382 T10380 pobj phenotype,for
R2959 T10383 T10382 amod developmental,phenotype
R2960 T10384 T10372 punct ", ",examined
R2961 T10385 T10372 nsubj we,examined
R2962 T10386 T10387 det both,parents
R2963 T10387 T10372 dobj parents,examined
R2964 T10388 T10372 punct .,examined
R2965 T10390 T10391 nsubjpass Paternity,confirmed
R2966 T10392 T10391 auxpass was,confirmed
R2967 T10393 T10391 punct ", ",confirmed
R2968 T10394 T10391 cc and,confirmed
R2969 T10395 T10396 compound sequence,analysis
R2970 T10396 T10397 nsubj analysis,revealed
R2971 T10397 T10391 conj revealed,confirmed
R2972 T10398 T10399 mark that,carried
R2973 T10399 T10397 ccomp carried,revealed
R2974 T10400 T10401 det the,parent
R2975 T10401 T10399 nsubj parent,carried
R2976 T10402 T10401 preconj neither,parent
R2977 T10403 T10404 det this,mutation
R2978 T10404 T10399 dobj mutation,carried
R2979 T10405 T10397 punct ", ",revealed
R2980 T10406 T10397 advcl proving,revealed
R2981 T10407 T10408 mark that,had
R2982 T10408 T10406 ccomp had,proving
R2983 T10409 T10410 det the,patient
R2984 T10410 T10408 nsubj patient,had
R2985 T10411 T10412 det a,mutation
R2986 T10412 T10408 dobj mutation,had
R2987 T10413 T10414 advmod de,novo
R2988 T10414 T10412 amod novo,mutation
R2989 T10415 T10408 prep in,had
R2990 T10416 T10415 pobj FOG2,in
R2991 T10417 T10418 punct (,Figure
R2992 T10418 T10397 parataxis Figure,revealed
R2993 T10419 T10418 nummod 7,Figure
R2994 T10420 T10418 punct ),Figure
R2995 T10421 T10397 punct .,revealed
R3008 T13037 T13038 amod Congenital,defects
R3009 T13038 T13040 nsubj defects,are
R3010 T13039 T13038 amod diaphragmatic,defects
R3011 T13041 T13042 det a,group
R3012 T13042 T13040 attr group,are
R3013 T13043 T13042 amod heterogeneous,group
R3014 T13044 T13042 prep of,group
R3015 T13045 T13044 pobj disorders,of
R3016 T13046 T13045 prep of,disorders
R3017 T13047 T13048 amod unknown,etiology
R3018 T13048 T13046 pobj etiology,of
R3019 T13049 T13040 punct .,are
R3020 T13051 T13052 det The,defects
R3021 T13052 T13053 nsubj defects,include
R3022 T13054 T13055 dep that,present
R3023 T13055 T13052 relcl present,defects
R3024 T13056 T13055 prep in,present
R3025 T13057 T13058 det the,period
R3026 T13058 T13056 pobj period,in
R3027 T13059 T13060 advmod pre,perinatal
R3028 T13060 T13058 amod perinatal,period
R3029 T13061 T13060 punct -,perinatal
R3030 T13062 T13060 cc or,perinatal
R3031 T13063 T13064 compound Bochdalek,hernia
R3032 T13064 T13053 dobj hernia,include
R3033 T13065 T13064 punct ", ",hernia
R3034 T13066 T13067 amod diaphragmatic,aplasia
R3035 T13067 T13064 conj aplasia,hernia
R3036 T13068 T13067 punct ", ",aplasia
R3037 T13069 T13067 cc and,aplasia
R3038 T13070 T13071 amod various,degrees
R3039 T13071 T13067 conj degrees,aplasia
R3040 T13072 T13071 prep of,degrees
R3041 T13073 T13074 compound muscularization,defects
R3042 T13074 T13072 pobj defects,of
R3043 T13075 T13074 cc or,defects
R3044 T13076 T13074 conj eventrations,defects
R3045 T13077 T13053 punct .,include
R3046 T13079 T13080 amod Different,types
R3047 T13080 T13081 nsubj types,occur
R3048 T13082 T13080 prep of,types
R3049 T13083 T13082 pobj defects,of
R3050 T13084 T13081 prep in,occur
R3051 T13085 T13086 det the,patients
R3052 T13086 T13084 pobj patients,in
R3053 T13087 T13086 amod same,patients
R3054 T13088 T13084 cc or,in
R3055 T13089 T13084 conj in,in
R3056 T13090 T13089 pobj siblings,in
R3057 T13091 T13081 punct ", ",occur
R3058 T13092 T13081 advcl suggesting,occur
R3059 T13093 T13094 nsubj these,represent
R3060 T13094 T13092 advcl represent,suggesting
R3061 T13095 T13096 amod variable,expression
R3062 T13096 T13094 dobj expression,represent
R3063 T13097 T13096 prep of,expression
R3064 T13098 T13099 det the,pathogenesis
R3065 T13099 T13097 pobj pathogenesis,of
R3066 T13100 T13099 amod same,pathogenesis
R3067 T13101 T13099 amod underlying,pathogenesis
R3068 T13102 T13103 punct [,31
R3069 T13103 T13081 parataxis 31,occur
R3070 T13104 T13103 nummod 30,31
R3071 T13105 T13103 punct ",",31
R3072 T13106 T13103 punct ],31
R3073 T13107 T13081 punct .,occur
R3074 T13109 T13110 amod Clinical,differentiation
R3075 T13110 T13111 nsubj differentiation,be
R3076 T13112 T13110 prep between,differentiation
R3077 T13113 T13114 det these,defects
R3078 T13114 T13112 pobj defects,between
R3079 T13115 T13111 aux may,be
R3080 T13116 T13117 advmod very,difficult
R3081 T13117 T13111 acomp difficult,be
R3082 T13118 T13111 punct ", ",be
R3083 T13119 T13120 mark as,is
R3084 T13120 T13111 advcl is,be
R3085 T13121 T13122 det the,diaphragm
R3086 T13122 T13120 nsubj diaphragm,is
R3087 T13123 T13122 amod residual,diaphragm
R3088 T13124 T13122 amod membranous,diaphragm
R3089 T13125 T13122 prep of,diaphragm
R3090 T13126 T13127 det a,defect
R3091 T13127 T13125 pobj defect,of
R3092 T13128 T13127 compound muscularization,defect
R3093 T13129 T13120 acomp thin,is
R3094 T13130 T13120 cc and,is
R3095 T13131 T13132 aux may,be
R3096 T13132 T13120 conj be,is
R3097 T13133 T13132 neg not,be
R3098 T13134 T13135 advmod easily,visible
R3099 T13135 T13132 acomp visible,be
R3100 T13136 T13132 prep on,be
R3101 T13137 T13138 amod prenatal,ultrasound
R3102 T13138 T13136 pobj ultrasound,on
R3103 T13139 T13138 cc or,ultrasound
R3104 T13140 T13141 amod postnatal,radiographs
R3105 T13141 T13138 conj radiographs,ultrasound
R3106 T13142 T13141 compound chest,radiographs
R3107 T13143 T13144 punct [,32
R3108 T13144 T13111 parataxis 32,be
R3109 T13145 T13144 punct ],32
R3110 T13146 T13111 punct .,be
R3111 T13148 T13149 mark Although,considered
R3112 T13149 T13155 advcl considered,been
R3113 T13150 T13151 amod diaphragmatic,defects
R3114 T13151 T13149 nsubjpass defects,considered
R3115 T13152 T13151 compound muscularization,defects
R3116 T13153 T13149 auxpass were,considered
R3117 T13154 T13149 advmod historically,considered
R3118 T13156 T13157 aux to,be
R3119 T13157 T13149 xcomp be,considered
R3120 T13158 T13157 acomp predictive,be
R3121 T13159 T13158 prep of,predictive
R3122 T13160 T13161 det a,outcome
R3123 T13161 T13159 pobj outcome,of
R3124 T13162 T13161 amod good,outcome
R3125 T13163 T13155 punct ", ",been
R3126 T13164 T13155 expl there,been
R3127 T13165 T13155 aux have,been
R3128 T13166 T13167 amod inadequate,studies
R3129 T13167 T13155 attr studies,been
R3130 T13168 T13169 npadvmod population,based
R3131 T13169 T13167 amod based,studies
R3132 T13170 T13169 punct -,based
R3133 T13171 T13172 dep that,include
R3134 T13172 T13167 relcl include,studies
R3135 T13173 T13174 amod fetal,cases
R3136 T13174 T13172 dobj cases,include
R3137 T13175 T13173 cc or,fetal
R3138 T13176 T13173 conj neonatal,fetal
R3139 T13177 T13174 cc and,cases
R3140 T13178 T13179 compound autopsy,diagnoses
R3141 T13179 T13174 conj diagnoses,cases
R3142 T13180 T13181 aux to,make
R3143 T13181 T13172 advcl make,include
R3144 T13182 T13183 det this,conclusion
R3145 T13183 T13184 nsubj conclusion,definitive
R3146 T13184 T13181 ccomp definitive,make
R3147 T13185 T13155 punct .,been
R3148 T13187 T13188 prep In,indicate
R3149 T13189 T13187 pobj fact,In
R3150 T13190 T13188 punct ", ",indicate
R3151 T13191 T13192 det the,series
R3152 T13192 T13188 nsubj series,indicate
R3153 T13193 T13192 prep of,series
R3154 T13194 T13193 pobj patients,of
R3155 T13195 T13196 nsubj we,report
R3156 T13196 T13194 advcl report,patients
R3157 T13197 T13196 advmod here,report
R3158 T13198 T13192 cc and,series
R3159 T13199 T13200 det the,literature
R3160 T13200 T13192 conj literature,series
R3161 T13201 T13200 amod published,literature
R3162 T13202 T13203 mark that,associated
R3163 T13203 T13188 ccomp associated,indicate
R3164 T13204 T13205 det an,defect
R3165 T13205 T13203 nsubjpass defect,associated
R3166 T13206 T13205 compound eventration,defect
R3167 T13207 T13203 aux may,associated
R3168 T13208 T13203 auxpass be,associated
R3169 T13209 T13203 prep with,associated
R3170 T13210 T13209 pobj displacement,with
R3171 T13211 T13210 prep of,displacement
R3172 T13212 T13213 amod abdominal,contents
R3173 T13213 T13211 pobj contents,of
R3174 T13214 T13209 cc and,with
R3175 T13215 T13214 advmod also,and
R3176 T13216 T13209 conj with,with
R3177 T13217 T13218 amod severe,hypoplasia
R3178 T13218 T13216 pobj hypoplasia,with
R3179 T13219 T13218 amod pulmonary,hypoplasia
R3180 T13220 T13218 cc and,hypoplasia
R3181 T13221 T13222 amod respiratory,insufficiency
R3182 T13222 T13218 conj insufficiency,hypoplasia
R3183 T13223 T13224 punct [,34
R3184 T13224 T13188 parataxis 34,indicate
R3185 T13225 T13224 nummod 33,34
R3186 T13226 T13224 punct ",",34
R3187 T13227 T13224 punct ],34
R3188 T13228 T13188 punct .,indicate
R3189 T13230 T13231 amod Numerous,abnormalities
R3190 T13231 T13233 nsubjpass abnormalities,found
R3191 T13232 T13231 compound chromosome,abnormalities
R3192 T13234 T13233 aux have,found
R3193 T13235 T13233 auxpass been,found
R3194 T13236 T13233 prep in,found
R3195 T13237 T13236 pobj association,in
R3196 T13238 T13237 prep with,association
R3197 T13239 T13240 amod congenital,abnormalities
R3198 T13240 T13238 pobj abnormalities,with
R3199 T13241 T13240 compound diaphragm,abnormalities
R3200 T13242 T13243 punct [,35
R3201 T13243 T13233 parataxis 35,found
R3202 T13244 T13243 nummod 12,35
R3203 T13245 T13243 punct ",",35
R3204 T13246 T13243 punct ],35
R3205 T13247 T13233 punct .,found
R3206 T13249 T13250 amod Human,FOG2
R3207 T13250 T13251 nsubj FOG2,maps
R3208 T13252 T13251 prep to,maps
R3209 T13253 T13252 pobj Chromosome,to
R3210 T13254 T13253 nummod 8q23.1,Chromosome
R3211 T13255 T13251 punct ", ",maps
R3212 T13256 T13251 cc and,maps
R3213 T13257 T13251 punct ", ",maps
R3214 T13258 T13259 advmod importantly,reported
R3215 T13259 T13251 conj reported,maps
R3216 T13260 T13259 punct ", ",reported
R3217 T13261 T13262 amod several,patients
R3218 T13262 T13259 nsubjpass patients,reported
R3219 T13263 T13262 prep with,patients
R3220 T13264 T13265 compound diaphragm,defects
R3221 T13265 T13263 pobj defects,with
R3222 T13266 T13265 cc and,defects
R3223 T13267 T13265 conj rearrangements,defects
R3224 T13268 T13267 acl involving,rearrangements
R3225 T13269 T13270 det this,locus
R3226 T13270 T13268 dobj locus,involving
R3227 T13271 T13259 aux have,reported
R3228 T13272 T13259 auxpass been,reported
R3229 T13273 T13259 punct .,reported
R3230 T13275 T13276 advmod Specifically,are
R3231 T13277 T13276 punct ", ",are
R3232 T13278 T13276 expl there,are
R3233 T13279 T13280 nummod three,patients
R3234 T13280 T13276 attr patients,are
R3235 T13281 T13280 amod unrelated,patients
R3236 T13282 T13280 compound CDH,patients
R3237 T13283 T13280 prep with,patients
R3238 T13284 T13285 advmod cytogenetically,balanced
R3239 T13285 T13286 amod balanced,translocations
R3240 T13286 T13283 pobj translocations,with
R3241 T13287 T13286 prep at,translocations
R3242 T13288 T13287 cc or,at
R3243 T13289 T13287 conj near,at
R3244 T13290 T13291 det the,locus
R3245 T13291 T13289 pobj locus,near
R3246 T13292 T13291 compound FOG2,locus
R3247 T13293 T13294 punct [,37
R3248 T13294 T13276 parataxis 37,are
R3249 T13295 T13294 nummod 36,37
R3250 T13296 T13294 punct ",",37
R3251 T13297 T13294 punct ],37
R3252 T13298 T13276 punct .,are
R3253 T13300 T13301 advmod Additionally,died
R3254 T13302 T13301 punct ", ",died
R3255 T13303 T13304 nummod two,patients
R3256 T13304 T13301 nsubj patients,died
R3257 T13305 T13304 prep with,patients
R3258 T13306 T13305 pobj deletions,with
R3259 T13307 T13308 advmod apparently,encompassing
R3260 T13308 T13306 acl encompassing,deletions
R3261 T13309 T13310 det the,locus
R3262 T13310 T13308 dobj locus,encompassing
R3263 T13311 T13310 compound FOG2,locus
R3264 T13312 T13301 aux have,died
R3265 T13313 T13301 prep from,died
R3266 T13314 T13315 amod multiple,anomalies
R3267 T13315 T13313 pobj anomalies,from
R3268 T13316 T13315 amod congenital,anomalies
R3269 T13317 T13315 prep including,anomalies
R3270 T13318 T13317 pobj CDH,including
R3271 T13319 T13320 punct [,38
R3272 T13320 T13301 parataxis 38,died
R3273 T13321 T13322 punct –,40
R3274 T13322 T13320 prep 40,38
R3275 T13323 T13320 punct ],38
R3276 T13324 T13301 punct .,died
R3277 T13326 T13327 nsubj Inactivation,result
R3278 T13328 T13326 prep of,Inactivation
R3279 T13329 T13330 det this,gene
R3280 T13330 T13328 pobj gene,of
R3281 T13331 T13326 prep due,Inactivation
R3282 T13332 T13331 pcomp to,due
R3283 T13333 T13334 amod chromosomal,rearrangement
R3284 T13334 T13331 pobj rearrangement,due
R3285 T13335 T13334 cc or,rearrangement
R3286 T13336 T13334 conj deletion,rearrangement
R3287 T13337 T13327 aux would,result
R3288 T13338 T13327 prep in,result
R3289 T13339 T13340 det a,mutation
R3290 T13340 T13338 pobj mutation,in
R3291 T13341 T13340 amod heterozygous,mutation
R3292 T13342 T13340 amod null,mutation
R3293 T13343 T13340 amod similar,mutation
R3294 T13344 T13343 prep to,similar
R3295 T13345 T13344 pobj that,to
R3296 T13346 T13345 acl found,that
R3297 T13347 T13346 prep in,found
R3298 T13348 T13349 det the,patient
R3299 T13349 T13347 pobj patient,in
R3300 T13350 T13351 nsubj we,report
R3301 T13351 T13349 advcl report,patient
R3302 T13352 T13327 punct .,result
R3303 T13354 T13355 mark Because,is
R3304 T13355 T13361 advcl is,suggest
R3305 T13356 T13357 det the,mutation
R3306 T13463 T13464 advmod more,common
R3307 T13464 T13462 amod common,CDH
R3308 T13357 T13355 nsubj mutation,is
R3309 T13465 T13462 compound Bochdalek,CDH
R3310 T13358 T13357 compound FOG2,mutation
R3311 T13359 T13360 nsubj we,report
R3312 T13466 T13452 punct ", ",is
R3313 T13360 T13357 advcl report,mutation
R3314 T13467 T13468 mark as,are
R3315 T13362 T13363 advmod de,novo
R3316 T13363 T13355 acomp novo,is
R3317 T13468 T13452 advcl are,is
R3318 T13364 T13355 cc and,is
R3319 T13365 T13366 det the,phenotypes
R3320 T13469 T13470 det the,mechanisms
R3321 T13366 T13367 nsubj phenotypes,are
R3322 T13367 T13355 conj are,is
R3323 T13368 T13366 prep of,phenotypes
R3324 T13470 T13468 nsubj mechanisms,are
R3325 T13369 T13370 det the,defects
R3326 T13370 T13368 pobj defects,of
R3327 T13371 T13370 amod pulmonary,defects
R3328 T13471 T13470 amod pathogenic,mechanisms
R3329 T13372 T13371 cc and,pulmonary
R3330 T13373 T13371 conj diaphragmatic,pulmonary
R3331 T13374 T13367 acomp similar,are
R3332 T13472 T13470 prep for,mechanisms
R3333 T13473 T13472 pobj both,for
R3334 T13375 T13367 prep between,are
R3335 T13474 T13475 advmod largely,unknown
R3336 T13376 T13375 pobj mouse,between
R3337 T13377 T13376 cc and,mouse
R3338 T13475 T13468 acomp unknown,are
R3339 T13378 T13376 conj human,mouse
R3340 T13379 T13361 punct ", ",suggest
R3341 T13476 T13452 punct .,is
R3342 T13380 T13361 nsubj we,suggest
R3343 T13381 T13382 mark that,is
R3344 T13478 T13479 compound Muscle,precursors
R3345 T13382 T13361 ccomp is,suggest
R3346 T13383 T13384 det this,mutation
R3347 T13384 T13382 nsubj mutation,is
R3348 T13385 T13384 prep in,mutation
R3349 T13479 T13480 nsubj precursors,migrate
R3350 T13386 T13385 pobj FOG2,in
R3351 T13387 T13388 det the,cause
R3352 T13481 T13479 acl destined,precursors
R3353 T13388 T13382 attr cause,is
R3354 T13389 T13388 amod first,cause
R3355 T13390 T13388 amod reported,cause
R3356 T13391 T13388 prep of,cause
R3357 T13482 T13483 aux to,populate
R3358 T13392 T13393 det a,defect
R3359 T13393 T13391 pobj defect,of
R3360 T13394 T13393 amod human,defect
R3361 T13395 T13393 amod developmental,defect
R3362 T13396 T13393 amod diaphragmatic,defect
R3363 T13483 T13481 xcomp populate,destined
R3364 T13397 T13396 cc and,diaphragmatic
R3365 T13398 T13396 conj pulmonary,diaphragmatic
R3366 T13399 T13361 punct .,suggest
R3367 T13484 T13485 det the,diaphragm
R3368 T13401 T13402 prep In,appear
R3369 T13485 T13483 dobj diaphragm,populate
R3370 T13403 T13401 pobj contrast,In
R3371 T13404 T13403 prep to,contrast
R3372 T13486 T13480 prep from,migrate
R3373 T13405 T13406 det the,child
R3374 T13406 T13404 pobj child,to
R3375 T13407 T13406 amod affected,child
R3376 T13487 T13488 det the,dermomyotome
R3377 T13408 T13402 punct ", ",appear
R3378 T13409 T13402 nsubj mice,appear
R3379 T13488 T13486 pobj dermomyotome,from
R3380 T13410 T13409 amod heterozygous,mice
R3381 T13411 T13410 prep for,heterozygous
R3382 T13412 T13413 det a,mutation
R3383 T13489 T13488 amod lateral,dermomyotome
R3384 T13413 T13411 pobj mutation,for
R3385 T13414 T13413 amod null,mutation
R3386 T13415 T13413 prep of,mutation
R3387 T13490 T13488 prep of,dermomyotome
R3388 T13416 T13415 pobj Fog2,of
R3389 T13417 T13402 oprd normal,appear
R3390 T13491 T13492 amod cervical,somites
R3391 T13418 T13402 punct .,appear
R3392 T13420 T13421 advmod However,is
R3393 T13492 T13490 pobj somites,of
R3394 T13422 T13421 punct ", ",is
R3395 T13493 T13480 punct .,migrate
R3396 T13423 T13421 expl there,is
R3397 T13424 T13425 amod ample,precedent
R3398 T13425 T13421 attr precedent,is
R3399 T13495 T13496 advmod Prior,to
R3400 T13426 T13425 prep for,precedent
R3401 T13427 T13428 det the,observation
R3402 T13428 T13426 pobj observation,for
R3403 T13429 T13430 mark that,is
R3404 T13496 T13497 prep to,populate
R3405 T13430 T13428 acl is,observation
R3406 T13498 T13496 pobj migration,to
R3407 T13431 T13430 nsubj haploinsufficiency,is
R3408 T13432 T13431 prep of,haploinsufficiency
R3409 T13433 T13434 det a,gene
R3410 T13434 T13432 pobj gene,of
R3411 T13435 T13434 prep with,gene
R3412 T13436 T13437 amod developmental,functions
R3413 T13437 T13435 pobj functions,with
R3414 T13499 T13498 prep onto,migration
R3415 T13438 T13439 advmod much,less
R3416 T13439 T13440 advmod less,well
R3417 T13440 T13441 advmod well,tolerated
R3418 T13441 T13430 acomp tolerated,is
R3419 T13500 T13501 det the,diaphragm
R3420 T13442 T13430 prep in,is
R3421 T13443 T13442 pobj humans,in
R3422 T13501 T13499 pobj diaphragm,onto
R3423 T13444 T13430 prep than,is
R3424 T13445 T13444 pobj mice,than
R3425 T13446 T13447 punct [,41
R3426 T13502 T13497 punct ", ",populate
R3427 T13447 T13421 parataxis 41,is
R3428 T13448 T13447 punct ],41
R3429 T13503 T13497 nsubj they,populate
R3430 T13449 T13421 punct .,is
R3431 T13451 T13452 nsubj It,is
R3432 T13504 T13505 det the,PPF
R3433 T13453 T13452 acomp unclear,is
R3434 T13454 T13455 advmod how,relates
R3435 T13505 T13497 dobj PPF,populate
R3436 T13455 T13452 ccomp relates,is
R3437 T13456 T13457 det the,defect
R3438 T13506 T13505 punct ", ",PPF
R3439 T13457 T13455 nsubj defect,relates
R3440 T13458 T13457 nmod Fog2,defect
R3441 T13459 T13457 amod diaphragmatic,defect
R3442 T13507 T13508 det a,tissue
R3443 T13460 T13455 prep to,relates
R3444 T13461 T13462 det the,CDH
R3445 T13508 T13505 appos tissue,PPF
R3446 T13509 T13510 npadvmod wedge,shaped
R3447 T13462 T13460 pobj CDH,to
R3448 T13510 T13508 amod shaped,tissue
R3449 T13511 T13510 punct -,shaped
R3450 T13512 T13513 dep that,tapers
R3451 T13513 T13508 relcl tapers,tissue
R3452 T13514 T13513 advmod medially,tapers
R3453 T13515 T13513 prep from,tapers
R3454 T13570 T13571 advmod Thus,results
R3455 T13516 T13517 det the,wall
R3456 T13572 T13571 punct ", ",results
R3457 T13517 T13515 pobj wall,from
R3458 T13573 T13574 det a,defect
R3459 T13574 T13571 nsubj defect,results
R3460 T13518 T13517 amod lateral,wall
R3461 T13575 T13574 prep in,defect
R3462 T13576 T13577 compound PPF,formation
R3463 T13577 T13575 pobj formation,in
R3464 T13578 T13571 advmod subsequently,results
R3465 T13579 T13571 prep in,results
R3466 T13580 T13581 det the,formation
R3467 T13519 T13517 compound body,wall
R3468 T13581 T13579 pobj formation,in
R3469 T13582 T13581 amod abnormal,formation
R3470 T13583 T13581 prep of,formation
R3471 T13520 T13513 prep to,tapers
R3472 T13584 T13585 det the,diaphragm
R3473 T13585 T13583 pobj diaphragm,of
R3474 T13521 T13522 det the,mesentery
R3475 T13586 T13587 punct [,43
R3476 T13587 T13571 parataxis 43,results
R3477 T13588 T13587 punct ],43
R3478 T13589 T13571 punct .,results
R3479 T13522 T13520 pobj mesentery,to
R3480 T13591 T13592 nsubj We,shown
R3481 T13523 T13522 amod esophageal,mesentery
R3482 T13593 T13592 aux have,shown
R3483 T13594 T13595 mark that,have
R3484 T13524 T13513 cc and,tapers
R3485 T13595 T13592 ccomp have,shown
R3486 T13596 T13597 det the,mutant
R3487 T13597 T13595 nsubj mutant,have
R3488 T13525 T13513 conj fuses,tapers
R3489 T13598 T13597 compound Fog2,mutant
R3490 T13599 T13595 aux does,have
R3491 T13600 T13601 det an,pattern
R3492 T13526 T13525 advmod ventrally,fuses
R3493 T13601 T13595 dobj pattern,have
R3494 T13602 T13601 amod abnormal,pattern
R3495 T13527 T13525 prep with,fuses
R3496 T13603 T13601 prep of,pattern
R3497 T13604 T13605 compound HGF,expression
R3498 T13605 T13603 pobj expression,of
R3499 T13528 T13529 det the,transversum
R3500 T13606 T13595 prep in,have
R3501 T13607 T13608 det the,region
R3502 T13608 T13606 pobj region,in
R3503 T13529 T13527 pobj transversum,with
R3504 T13609 T13610 prep through,migrate
R3505 T13610 T13608 relcl migrate,region
R3506 T13611 T13609 pobj which,through
R3507 T13530 T13529 compound septum,transversum
R3508 T13612 T13613 compound muscle,cells
R3509 T13613 T13610 nsubj cells,migrate
R3510 T13531 T13532 punct [,42
R3511 T13614 T13613 compound precursor,cells
R3512 T13615 T13610 prep onto,migrate
R3513 T13616 T13617 det the,diaphragm
R3514 T13617 T13615 pobj diaphragm,onto
R3515 T13618 T13617 amod developing,diaphragm
R3516 T13619 T13592 punct .,shown
R3517 T13532 T13497 parataxis 42,populate
R3518 T13533 T13532 punct ],42
R3519 T13621 T13622 det This,finding
R3520 T13534 T13497 punct .,populate
R3521 T13622 T13623 nsubj finding,account
R3522 T13536 T13537 compound Muscle,precursors
R3523 T13624 T13623 aux may,account
R3524 T13625 T13623 prep for,account
R3525 T13626 T13627 det the,muscle
R3526 T13537 T13538 nsubj precursors,reach
R3527 T13627 T13625 pobj muscle,for
R3528 T13628 T13629 advmod abnormally,patterned
R3529 T13629 T13627 amod patterned,muscle
R3530 T13539 T13540 det the,PPF
R3531 T13630 T13631 dep that,develops
R3532 T13631 T13627 relcl develops,muscle
R3533 T13632 T13631 prep in,develops
R3534 T13633 T13634 det the,diaphragm
R3535 T13540 T13538 dobj PPF,reach
R3536 T13541 T13538 prep by,reach
R3537 T13634 T13632 pobj diaphragm,in
R3538 T13542 T13541 pobj E11,by
R3539 T13635 T13636 compound Fog2,mutant
R3540 T13636 T13634 compound mutant,diaphragm
R3541 T13637 T13623 punct .,account
R3542 T13543 T13538 punct ", ",reach
R3543 T13639 T13640 mark Although,detected
R3544 T13544 T13545 advmod where,proliferate
R3545 T13640 T13646 advcl detected,need
R3546 T13641 T13642 nmod Pax3,expression
R3547 T13642 T13640 nsubjpass expression,detected
R3548 T13545 T13538 ccomp proliferate,reach
R3549 T13643 T13641 cc and,Pax3
R3550 T13546 T13545 nsubj they,proliferate
R3551 T13644 T13641 conj MyoD,Pax3
R3552 T13547 T13545 punct ", ",proliferate
R3553 T13645 T13640 auxpass is,detected
R3554 T13548 T13545 conj differentiate,proliferate
R3555 T13647 T13640 prep in,detected
R3556 T13648 T13649 det the,PPF
R3557 T13649 T13647 pobj PPF,in
R3558 T13549 T13548 punct ", ",differentiate
R3559 T13650 T13646 punct ", ",need
R3560 T13651 T13652 det a,analysis
R3561 T13652 T13646 nsubj analysis,need
R3562 T13550 T13548 cc and,differentiate
R3563 T13653 T13652 amod detailed,analysis
R3564 T13654 T13652 prep of,analysis
R3565 T13655 T13656 compound transcription,factors
R3566 T13656 T13654 pobj factors,of
R3567 T13657 T13656 amod responsible,factors
R3568 T13658 T13657 prep for,responsible
R3569 T13551 T13552 advmod then,migrate
R3570 T13659 T13660 compound muscle,cell
R3571 T13660 T13658 pobj cell,for
R3572 T13661 T13660 compound precursor,cell
R3573 T13662 T13660 appos migration,cell
R3574 T13552 T13548 conj migrate,differentiate
R3575 T13663 T13662 cc and,migration
R3576 T13664 T13662 conj differentiation,migration
R3577 T13553 T13552 prep toward,migrate
R3578 T13665 T13646 aux will,need
R3579 T13666 T13667 aux to,completed
R3580 T13667 T13646 xcomp completed,need
R3581 T13554 T13555 det the,regions
R3582 T13668 T13667 auxpass be,completed
R3583 T13669 T13670 preconj both,in
R3584 T13670 T13667 prep in,completed
R3585 T13555 T13553 pobj regions,toward
R3586 T13671 T13672 det the,PPF
R3587 T13672 T13670 pobj PPF,in
R3588 T13556 T13557 amod dorsolateral,costal
R3589 T13673 T13670 cc and,in
R3590 T13674 T13670 conj along,in
R3591 T13557 T13555 amod costal,regions
R3592 T13558 T13557 punct ", ",costal
R3593 T13559 T13560 amod sternal,costal
R3594 T13560 T13557 conj costal,costal
R3595 T13561 T13560 punct ", ",costal
R3596 T13675 T13676 det the,pathway
R3597 T13676 T13674 pobj pathway,along
R3598 T13677 T13676 prep of,pathway
R3599 T13562 T13560 cc and,costal
R3600 T13678 T13679 compound muscle,cell
R3601 T13679 T13681 compound cell,migration
R3602 T13680 T13679 compound precursor,cell
R3603 T13563 T13560 conj crural,costal
R3604 T13681 T13677 pobj migration,of
R3605 T13682 T13676 prep between,pathway
R3606 T13564 T13555 prep of,regions
R3607 T13683 T13684 det the,PPF
R3608 T13684 T13682 pobj PPF,between
R3609 T13685 T13684 cc and,PPF
R3610 T13565 T13566 det the,diaphragm
R3611 T13686 T13687 det the,diaphragm
R3612 T13687 T13684 conj diaphragm,PPF
R3613 T13688 T13687 amod membranous,diaphragm
R3614 T13566 T13564 pobj diaphragm,of
R3615 T13689 T13646 punct .,need
R3616 T13691 T13692 nsubj Fog2,interact
R3617 T13567 T13566 amod developing,diaphragm
R3618 T13693 T13692 aux can,interact
R3619 T13694 T13692 prep with,interact
R3620 T13695 T13694 pobj any,with
R3621 T13696 T13695 prep of,any
R3622 T13697 T13698 det the,factors
R3623 T13568 T13538 punct .,reach
R3624 T13698 T13696 pobj factors,of
R3625 T13699 T13698 compound Gata,factors
R3626 T13700 T13695 punct ", ",any
R3627 T13701 T13702 nmod Gatas,1
R3628 T13781 T13780 prep with,associated
R3629 T13702 T13695 appos 1,any
R3630 T13703 T13704 punct –,6
R3631 T13704 T13702 prep 6,1
R3632 T13705 T13695 punct ", ",any
R3633 T13782 T13783 amod abnormal,anatomy
R3634 T13706 T13707 advmod as,as
R3635 T13707 T13695 cc as,any
R3636 T13708 T13707 advmod well,as
R3637 T13783 T13781 pobj anatomy,with
R3638 T13709 T13710 amod other,factors
R3639 T13710 T13695 conj factors,any
R3640 T13711 T13710 compound transcription,factors
R3641 T13784 T13783 amod diaphragmatic,anatomy
R3642 T13712 T13713 amod such,as
R3643 T13713 T13710 prep as,factors
R3644 T13714 T13713 pobj CoupTFII,as
R3645 T13785 T13783 cc or,anatomy
R3646 T13715 T13716 punct [,45
R3647 T13716 T13692 parataxis 45,interact
R3648 T13717 T13716 nummod 44,45
R3649 T13786 T13783 conj function,anatomy
R3650 T13718 T13716 punct ",",45
R3651 T13719 T13716 punct ],45
R3652 T13787 T13779 punct ", ",is
R3653 T13720 T13692 punct .,interact
R3654 T13788 T13779 cc and,is
R3655 T13722 T13723 nsubjpass It,known
R3656 T13789 T13790 auxpass is,known
R3657 T13724 T13723 auxpass is,known
R3658 T13790 T13779 conj known,is
R3659 T13725 T13726 mark that,is
R3660 T13726 T13723 ccomp is,known
R3661 T13727 T13728 det a,interaction
R3662 T13791 T13792 aux to,occur
R3663 T13728 T13726 nsubj interaction,is
R3664 T13729 T13730 compound Fog2,Gata4
R3665 T13792 T13790 xcomp occur,known
R3666 T13730 T13728 compound Gata4,interaction
R3667 T13731 T13730 punct –,Gata4
R3668 T13732 T13726 acomp critical,is
R3669 T13793 T13792 prep as,occur
R3670 T13733 T13732 prep for,critical
R3671 T13734 T13735 amod normal,development
R3672 T13735 T13733 pobj development,for
R3673 T13736 T13735 amod cardiac,development
R3674 T13737 T13736 cc and,cardiac
R3675 T13738 T13736 conj gonadal,cardiac
R3676 T13794 T13795 det a,defect
R3677 T13739 T13723 punct ", ",known
R3678 T13740 T13723 cc but,known
R3679 T13741 T13742 amod interacting,factors
R3680 T13795 T13793 pobj defect,as
R3681 T13742 T13743 nsubjpass factors,determined
R3682 T13743 T13723 conj determined,known
R3683 T13744 T13742 prep in,factors
R3684 T13796 T13795 amod secondary,defect
R3685 T13745 T13746 det the,lung
R3686 T13746 T13744 pobj lung,in
R3687 T13747 T13746 cc and,lung
R3688 T13797 T13795 amod developmental,defect
R3689 T13748 T13746 conj diaphragm,lung
R3690 T13749 T13743 aux have,determined
R3691 T13750 T13743 neg not,determined
R3692 T13798 T13792 prep in,occur
R3693 T13751 T13743 advmod yet,determined
R3694 T13752 T13743 auxpass been,determined
R3695 T13799 T13798 pobj models,in
R3696 T13753 T13743 punct .,determined
R3697 T13755 T13756 det The,severity
R3698 T13800 T13799 prep of,models
R3699 T13756 T13757 nsubj severity,was
R3700 T13801 T13802 amod diaphragmatic,dysfunction
R3701 T13758 T13756 prep of,severity
R3702 T13759 T13760 amod pulmonary,hypoplasia
R3703 T13760 T13758 pobj hypoplasia,of
R3704 T13761 T13756 prep in,severity
R3705 T13802 T13800 pobj dysfunction,of
R3706 T13762 T13763 det the,patient
R3707 T13763 T13761 pobj patient,in
R3708 T13803 T13804 amod such,as
R3709 T13764 T13765 nsubj we,report
R3710 T13765 T13763 advcl report,patient
R3711 T13766 T13757 prep out,was
R3712 T13767 T13766 prep of,out
R3713 T13804 T13802 prep as,dysfunction
R3714 T13768 T13767 pobj proportion,of
R3715 T13769 T13768 prep to,proportion
R3716 T13805 T13806 amod complete,amuscularization
R3717 T13770 T13769 pobj that,to
R3718 T13771 T13770 prep of,that
R3719 T13772 T13773 det the,defect
R3720 T13806 T13804 pobj amuscularization,as
R3721 T13773 T13771 pobj defect,of
R3722 T13774 T13773 compound diaphragm,defect
R3723 T13775 T13757 punct .,was
R3724 T13777 T13778 amod Pulmonary,hypoplasia
R3725 T13807 T13808 punct [,17
R3726 T13778 T13779 nsubj hypoplasia,is
R3727 T13780 T13779 acomp associated,is
R3728 T13808 T13806 parataxis 17,amuscularization
R3729 T13809 T13808 punct ],17
R3730 T13810 T13806 cc or,amuscularization
R3731 T13887 T13884 agent by,suspected
R3732 T13888 T13887 pobj clinicians,by
R3733 T13811 T13812 amod phrenic,nerve
R3734 T13889 T13890 dep who,care
R3735 T13890 T13888 relcl care,clinicians
R3736 T13891 T13890 prep for,care
R3737 T13812 T13813 compound nerve,disruption
R3738 T13892 T13893 det these,patients
R3739 T13813 T13806 conj disruption,amuscularization
R3740 T13814 T13815 punct [,46
R3741 T13815 T13813 parataxis 46,disruption
R3742 T13893 T13891 pobj patients,for
R3743 T13894 T13847 punct .,suggested
R3744 T13816 T13815 punct ],46
R3745 T13896 T13897 prep In,supports
R3746 T13817 T13779 punct .,is
R3747 T13898 T13896 pobj addition,In
R3748 T13899 T13897 punct ", ",supports
R3749 T13900 T13901 det the,incidence
R3750 T13819 T13820 nsubj It,occurs
R3751 T13901 T13897 nsubj incidence,supports
R3752 T13902 T13901 amod high,incidence
R3753 T13903 T13901 prep of,incidence
R3754 T13821 T13820 prep in,occurs
R3755 T13904 T13905 compound lobar,abnormalities
R3756 T13905 T13903 pobj abnormalities,of
R3757 T13906 T13905 amod associated,abnormalities
R3758 T13907 T13906 prep with,associated
R3759 T13822 T13823 det a,model
R3760 T13908 T13907 pobj CDH,with
R3761 T13909 T13910 punct [,52
R3762 T13910 T13901 parataxis 52,incidence
R3763 T13823 T13821 pobj model,in
R3764 T13911 T13910 punct ],52
R3765 T13912 T13913 det the,possibility
R3766 T13913 T13897 dobj possibility,supports
R3767 T13824 T13823 amod surgical,model
R3768 T13914 T13915 mark that,associated
R3769 T13915 T13913 acl associated,possibility
R3770 T13825 T13823 prep of,model
R3771 T13916 T13917 det this,disorder
R3772 T13917 T13915 nsubjpass disorder,associated
R3773 T13918 T13915 aux can,associated
R3774 T13919 T13915 auxpass be,associated
R3775 T13920 T13915 prep with,associated
R3776 T13921 T13922 det a,abnormality
R3777 T13826 T13825 pobj CDH,of
R3778 T13922 T13920 pobj abnormality,with
R3779 T13923 T13922 amod primary,abnormality
R3780 T13924 T13922 amod developmental,abnormality
R3781 T13827 T13828 prep in,created
R3782 T13925 T13922 amod pulmonary,abnormality
R3783 T13926 T13897 punct .,supports
R3784 T13828 T13823 relcl created,model
R3785 T13928 T13929 poss Our,analysis
R3786 T13929 T13930 nsubj analysis,proves
R3787 T13829 T13827 pobj which,in
R3788 T13931 T13929 prep of,analysis
R3789 T13932 T13931 pobj mice,of
R3790 T13830 T13831 det a,hernia
R3791 T13933 T13932 acl carrying,mice
R3792 T13934 T13933 dobj mutations,carrying
R3793 T13935 T13934 prep of,mutations
R3794 T13831 T13828 nsubjpass hernia,created
R3795 T13936 T13935 pobj Fog2,of
R3796 T13937 T13938 mark that,is
R3797 T13938 T13930 ccomp is,proves
R3798 T13832 T13828 auxpass is,created
R3799 T13939 T13938 expl there,is
R3800 T13940 T13941 det a,defect
R3801 T13833 T13828 advmod physically,created
R3802 T13941 T13938 attr defect,is
R3803 T13942 T13941 amod primary,defect
R3804 T13943 T13941 prep in,defect
R3805 T13944 T13945 compound lung,development
R3806 T13834 T13828 prep in,created
R3807 T13945 T13943 pobj development,in
R3808 T13946 T13947 dep that,results
R3809 T13947 T13941 relcl results,defect
R3810 T13835 T13836 det an,lamb
R3811 T13948 T13947 prep in,results
R3812 T13949 T13950 amod specific,loss
R3813 T13950 T13948 pobj loss,in
R3814 T13836 T13834 pobj lamb,in
R3815 T13951 T13950 prep of,loss
R3816 T13952 T13953 det the,lobe
R3817 T13953 T13951 pobj lobe,of
R3818 T13837 T13838 advmod in,utero
R3819 T13954 T13953 amod accessory,lobe
R3820 T13955 T13950 cc and,loss
R3821 T13956 T13957 amod partial,loss
R3822 T13838 T13836 amod utero,lamb
R3823 T13957 T13950 conj loss,loss
R3824 T13958 T13957 prep of,loss
R3825 T13959 T13960 det the,lobe
R3826 T13960 T13958 pobj lobe,of
R3827 T13961 T13960 amod right,lobe
R3828 T13839 T13840 punct [,48
R3829 T13962 T13960 amod middle,lobe
R3830 T13963 T13930 punct .,proves
R3831 T13840 T13820 parataxis 48,occurs
R3832 T13965 T13966 det The,defects
R3833 T13966 T13969 nsubj defects,prompted
R3834 T13967 T13966 amod specific,defects
R3835 T13841 T13840 nummod 47,48
R3836 T13968 T13966 compound lobar,defects
R3837 T13970 T13969 dobj us,prompted
R3838 T13971 T13972 aux to,evaluate
R3839 T13842 T13840 punct ",",48
R3840 T13972 T13969 xcomp evaluate,prompted
R3841 T13973 T13974 compound Fog2,expression
R3842 T13843 T13840 punct ],48
R3843 T13974 T13972 dobj expression,evaluate
R3844 T13975 T13972 prep at,evaluate
R3845 T13976 T13977 det the,time
R3846 T13844 T13820 punct .,occurs
R3847 T13977 T13975 pobj time,at
R3848 T13978 T13977 prep of,time
R3849 T13979 T13980 amod early,budding
R3850 T13846 T13847 advmod However,suggested
R3851 T13980 T13978 pobj budding,of
R3852 T13848 T13847 punct ", ",suggested
R3853 T13981 T13980 compound lobar,budding
R3854 T13982 T13969 punct .,prompted
R3855 T13849 T13850 det the,possibility
R3856 T13984 T13985 mark While,is
R3857 T13985 T13988 advcl is,expressed
R3858 T13986 T13987 compound Fog2,expression
R3859 T13850 T13847 nsubjpass possibility,suggested
R3860 T13987 T13985 nsubj expression,is
R3861 T13989 T13985 acomp diffuse,is
R3862 T13851 T13852 mark that,occur
R3863 T13990 T13985 prep in,is
R3864 T13991 T13992 det the,mesenchyme
R3865 T13992 T13990 pobj mesenchyme,in
R3866 T13852 T13850 acl occur,possibility
R3867 T13853 T13854 amod primary,abnormalities
R3868 T13854 T13852 nsubj abnormalities,occur
R3869 T13993 T13992 amod pulmonary,mesenchyme
R3870 T13994 T13995 mark after,is
R3871 T13855 T13854 amod pulmonary,abnormalities
R3872 T13995 T13985 advcl is,is
R3873 T13996 T13997 compound lobar,structure
R3874 T13856 T13854 amod developmental,abnormalities
R3875 T13997 T13995 nsubj structure,is
R3876 T13998 T13999 advmod well,established
R3877 T13999 T13995 acomp established,is
R3878 T14000 T14001 punct (,E12.5
R3879 T14001 T13995 parataxis E12.5,is
R3880 T14002 T14001 punct ),E12.5
R3881 T13857 T13852 prep with,occur
R3882 T14003 T13988 punct ", ",expressed
R3883 T14004 T13988 nsubjpass it,expressed
R3884 T14005 T13988 auxpass is,expressed
R3885 T13858 T13857 punct ", ",with
R3886 T14006 T14007 advmod more,focally
R3887 T14007 T13988 advmod focally,expressed
R3888 T14008 T13988 prep in,expressed
R3889 T13859 T13860 advmod rather,than
R3890 T14009 T14010 det the,mesenchyme
R3891 T13860 T13857 cc than,with
R3892 T13861 T13857 advmod secondary,with
R3893 T14010 T14008 pobj mesenchyme,in
R3894 T14011 T14010 acl surrounding,mesenchyme
R3895 T13862 T13861 prep to,secondary
R3896 T14012 T14013 det the,lobe
R3897 T14013 T14011 dobj lobe,surrounding
R3898 T13863 T13857 punct ", ",with
R3899 T14014 T14013 amod right,lobe
R3900 T14015 T14013 amod middle,lobe
R3901 T14016 T14013 cc and,lobe
R3902 T13864 T13865 amod diaphragmatic,defects
R3903 T14017 T14018 amod accessory,buds
R3904 T14018 T14013 conj buds,lobe
R3905 T14019 T14020 mark as,form
R3906 T13865 T13857 conj defects,with
R3907 T14020 T13988 advcl form,expressed
R3908 T14021 T14022 det these,lobes
R3909 T13866 T13847 aux has,suggested
R3910 T14022 T14020 nsubj lobes,form
R3911 T14023 T13988 punct .,expressed
R3912 T13867 T13847 auxpass been,suggested
R3913 T14025 T14026 nsubj This,matches
R3914 T13868 T13847 agent by,suggested
R3915 T14027 T14028 det the,phenotype
R3916 T14028 T14026 dobj phenotype,matches
R3917 T14029 T14028 prep of,phenotype
R3918 T13869 T13868 pobj others,by
R3919 T14030 T14031 amod right,lobe
R3920 T14031 T14033 nmod lobe,loss
R3921 T14032 T14031 amod middle,lobe
R3922 T13870 T13847 prep based,suggested
R3923 T14033 T14029 pobj loss,of
R3924 T14034 T14031 cc and,lobe
R3925 T14035 T14036 amod accessory,lobe
R3926 T13871 T13870 prep on,based
R3927 T14036 T14031 conj lobe,lobe
R3928 T14037 T14026 punct ", ",matches
R3929 T14038 T14026 cc and,matches
R3930 T14039 T14026 conj suggests,matches
R3931 T14040 T14041 mark that,has
R3932 T14041 T14039 ccomp has,suggests
R3933 T13872 T13873 det a,model
R3934 T14042 T14041 nsubj Fog2,has
R3935 T14043 T14044 det a,role
R3936 T14044 T14041 dobj role,has
R3937 T13873 T13871 pobj model,on
R3938 T14045 T14044 amod specific,role
R3939 T14046 T14044 compound patterning,role
R3940 T14047 T14044 prep in,role
R3941 T13874 T13873 amod teratogenic,model
R3942 T14048 T14047 pobj establishment,in
R3943 T14049 T14048 prep of,establishment
R3944 T14050 T14051 det these,lobes
R3945 T13875 T13873 prep of,model
R3946 T14051 T14049 pobj lobes,of
R3947 T14052 T14026 punct .,matches
R3948 T13876 T13875 pobj CDH,of
R3949 T14054 T14055 nsubj It,is
R3950 T13877 T13878 punct [,49
R3951 T14056 T14057 advmod less,clear
R3952 T14057 T14055 acomp clear,is
R3953 T14058 T14059 mark whether,results
R3954 T13878 T13847 parataxis 49,suggested
R3955 T14059 T14055 ccomp results,is
R3956 T14060 T14059 nsubj loss,results
R3957 T14061 T14060 prep of,loss
R3958 T13879 T13880 punct –,51
R3959 T14062 T14061 pobj Fog2,of
R3960 T14063 T14059 prep in,results
R3961 T13880 T13878 prep 51,49
R3962 T14064 T14065 det a,defect
R3963 T13881 T13878 punct ],49
R3964 T14065 T14063 pobj defect,in
R3965 T13882 T13847 cc and,suggested
R3966 T14066 T14065 amod global,defect
R3967 T13883 T13884 aux has,suspected
R3968 T14067 T14065 compound branching,defect
R3969 T14068 T14055 punct ", ",is
R3970 T14069 T14070 mark as,appear
R3971 T13884 T13847 conj suspected,suggested
R3972 T14070 T14055 advcl appear,is
R3973 T14071 T14072 compound Fog2,lungs
R3974 T14072 T14070 nsubj lungs,appear
R3975 T13885 T13884 advmod long,suspected
R3976 T14073 T14074 aux to,have
R3977 T14074 T14070 xcomp have,appear
R3978 T13886 T13884 auxpass been,suspected
R3979 T14075 T14076 det a,delay
R3980 T14076 T14074 dobj delay,have
R3981 T14099 T14097 pobj lobes,in
R3982 T14077 T14076 amod slight,delay
R3983 T14078 T14076 amod developmental,delay
R3984 T14079 T14076 punct ", ",delay
R3985 T14080 T14081 dep which,result
R3986 T14081 T14076 relcl result,delay
R3987 T14082 T14081 aux could,result
R3988 T14083 T14081 prep from,result
R3989 T14100 T14099 amod unaffected,lobes
R3990 T14084 T14085 amod many,causes
R3991 T14085 T14083 pobj causes,from
R3992 T14086 T14055 punct .,is
R3993 T14101 T14102 dep that,appears
R3994 T14088 T14089 amod Cultured,lungs
R3995 T14089 T14091 nsubj lungs,develop
R3996 T14090 T14089 compound Fog2,lungs
R3997 T14102 T14094 relcl appears,pattern
R3998 T14092 T14091 aux do,develop
R3999 T14093 T14094 det an,pattern
R4000 T14103 T14102 oprd similar,appears
R4001 T14094 T14091 dobj pattern,develop
R4002 T14095 T14094 amod intricate,pattern
R4003 T14096 T14094 compound branching,pattern
R4004 T14104 T14103 prep in,similar
R4005 T14097 T14094 prep in,pattern
R4006 T14098 T14099 det the,lobes
R4007 T14105 T14106 det the,pattern
R4008 T14106 T14104 pobj pattern,in
R4009 T14107 T14103 prep to,similar
R4010 T14108 T14109 amod wild,type
R4011 T14206 T14207 nsubj It,is
R4012 T14109 T14111 compound type,lungs
R4013 T14208 T14209 advmod only,as
R4014 T14209 T14207 prep as,is
R4015 T14110 T14109 punct -,type
R4016 T14210 T14211 det a,consequence
R4017 T14211 T14209 pobj consequence,as
R4018 T14212 T14211 prep of,consequence
R4019 T14111 T14107 pobj lungs,to
R4020 T14213 T14214 npadvmod phenotype,driven
R4021 T14214 T14216 amod driven,analyses
R4022 T14215 T14214 punct -,driven
R4023 T14112 T14091 prep after,develop
R4024 T14216 T14212 pobj analyses,of
R4025 T14217 T14218 amod such,as
R4026 T14218 T14216 prep as,analyses
R4027 T14113 T14114 nummod 5,d
R4028 T14219 T14218 pobj those,as
R4029 T14220 T14221 nsubj we,pursuing
R4030 T14221 T14219 advcl pursuing,those
R4031 T14114 T14112 pobj d,after
R4032 T14222 T14221 aux are,pursuing
R4033 T14223 T14224 mark that,has
R4034 T14224 T14207 ccomp has,is
R4035 T14225 T14224 nsubj one,has
R4036 T14226 T14227 det the,opportunity
R4037 T14115 T14114 prep in,d
R4038 T14227 T14224 dobj opportunity,has
R4039 T14228 T14229 aux to,assay
R4040 T14229 T14227 acl assay,opportunity
R4041 T14230 T14229 dobj all,assay
R4042 T14116 T14115 pobj culture,in
R4043 T14231 T14230 prep of,all
R4044 T14232 T14233 det the,derangements
R4045 T14233 T14231 pobj derangements,of
R4046 T14117 T14091 punct .,develop
R4047 T14234 T14233 amod potential,derangements
R4048 T14235 T14233 amod molecular,derangements
R4049 T14119 T14120 prep In,show
R4050 T14236 T14237 dep that,result
R4051 T14237 T14233 relcl result,derangements
R4052 T14238 T14237 aux may,result
R4053 T14121 T14122 det this,report
R4054 T14239 T14237 prep in,result
R4055 T14240 T14241 amod human,disease
R4056 T14122 T14119 pobj report,In
R4057 T14241 T14239 pobj disease,in
R4058 T14242 T14207 punct .,is
R4059 T14123 T14120 punct ", ",show
R4060 T14124 T14120 nsubj we,show
R4061 T14125 T14126 mark that,causes
R4062 T14126 T14120 ccomp causes,show
R4063 T14127 T14128 det a,mutation
R4064 T14128 T14126 nsubj mutation,causes
R4065 T14129 T14128 prep of,mutation
R4066 T14130 T14129 pobj Fog2,of
R4067 T14131 T14128 prep in,mutation
R4068 T14132 T14133 det the,mouse
R4069 T14133 T14131 pobj mouse,in
R4070 T14134 T14135 det the,phenotype
R4071 T14135 T14126 dobj phenotype,causes
R4072 T14136 T14135 prep of,phenotype
R4073 T14137 T14138 amod abnormal,muscularization
R4074 T14138 T14136 pobj muscularization,of
R4075 T14139 T14138 amod diaphragmatic,muscularization
R4076 T14140 T14138 cc and,muscularization
R4077 T14141 T14142 amod primary,hypoplasia
R4078 T14142 T14138 conj hypoplasia,muscularization
R4079 T14143 T14142 amod pulmonary,hypoplasia
R4080 T14144 T14120 punct .,show
R4081 T14146 T14147 nsubj We,demonstrate
R4082 T14148 T14147 advmod furthermore,demonstrate
R4083 T14149 T14150 mark that,is
R4084 T14150 T14147 ccomp is,demonstrate
R4085 T14151 T14152 det a,mutation
R4086 T14152 T14150 nsubj mutation,is
R4087 T14153 T14152 prep in,mutation
R4088 T14154 T14155 det this,gene
R4089 T14155 T14153 pobj gene,in
R4090 T14156 T14150 acomp associated,is
R4091 T14157 T14156 prep with,associated
R4092 T14158 T14159 det a,defect
R4093 T14159 T14157 pobj defect,with
R4094 T14160 T14159 amod lethal,defect
R4095 T14161 T14159 prep in,defect
R4096 T14162 T14163 nmod lung,development
R4097 T14163 T14161 pobj development,in
R4098 T14164 T14162 cc and,lung
R4099 T14165 T14162 conj diaphragm,lung
R4100 T14166 T14159 prep in,defect
R4101 T14167 T14168 det a,child
R4102 T14168 T14166 pobj child,in
R4103 T14169 T14147 punct .,demonstrate
R4104 T14171 T14172 nsubj It,is
R4105 T14173 T14172 acomp notable,is
R4106 T14174 T14175 mark that,recognized
R4107 T14175 T14172 ccomp recognized,is
R4108 T14176 T14175 punct ", ",recognized
R4109 T14177 T14175 prep despite,recognized
R4110 T14178 T14179 amod extensive,analysis
R4111 T14179 T14177 pobj analysis,despite
R4112 T14180 T14179 prep of,analysis
R4113 T14181 T14182 compound Fog2,biology
R4114 T14182 T14180 pobj biology,of
R4115 T14183 T14179 cc and,analysis
R4116 T14184 T14185 det the,generation
R4117 T14185 T14179 conj generation,analysis
R4118 T14186 T14185 prep of,generation
R4119 T14187 T14188 det a,mouse
R4120 T14188 T14186 pobj mouse,of
R4121 T14189 T14188 nmod Fog2,mouse
R4122 T14190 T14188 amod knock,mouse
R4123 T14191 T14190 punct -,knock
R4124 T14192 T14190 prt out,knock
R4125 T14193 T14175 punct ", ",recognized
R4126 T14194 T14195 poss its,role
R4127 T14195 T14175 nsubjpass role,recognized
R4128 T14196 T14195 prep in,role
R4129 T14197 T14198 nmod diaphragm,development
R4130 T14198 T14196 pobj development,in
R4131 T14199 T14197 cc and,diaphragm
R4132 T14200 T14197 conj lung,diaphragm
R4133 T14201 T14175 auxpass was,recognized
R4134 T14202 T14175 advmod previously,recognized
R4135 T14203 T14175 neg not,recognized
R4136 T14204 T14172 punct .,is
R4137 T14396 T14397 amod Genetic,mapping
R4138 T14398 T14397 prep of,mapping
R4139 T14399 T14400 det the,mutation
R4140 T14400 T14398 pobj mutation,of
R4141 T14401 T14400 compound mouse,mutation
R4142 T14402 T14400 appos lil,mutation
R4143 T14403 T14397 punct .,mapping
R4144 T14405 T14406 det The,mutation
R4145 T14406 T14408 nsubjpass mutation,identified
R4146 T14407 T14406 compound lil,mutation
R4147 T14409 T14408 auxpass was,identified
R4148 T14410 T14411 mark as,described
R4149 T14411 T14408 advcl described,identified
R4150 T14412 T14411 prep in,described
R4151 T14413 T14412 pobj results,in
R4152 T14414 T14408 punct .,identified
R4153 T14416 T14417 amod Wild,type
R4154 T14417 T14419 nmod type,mice
R4155 T14418 T14417 punct -,type
R4156 T14419 T14427 nsubjpass mice,obtained
R4157 T14420 T14421 nmod FVB,N
R4158 T14421 T14419 nmod N,mice
R4159 T14422 T14421 punct /,N
R4160 T14423 T14421 cc and,N
R4161 T14424 T14425 compound C57BL,6J
R4162 T14425 T14421 conj 6J,N
R4163 T14426 T14425 punct /,6J
R4164 T14428 T14419 acl used,mice
R4165 T14429 T14428 prep for,used
R4166 T14430 T14431 amod genetic,crosses
R4167 T14431 T14429 pobj crosses,for
R4168 T14432 T14427 auxpass were,obtained
R4169 T14433 T14427 prep from,obtained
R4170 T14434 T14435 det the,Laboratory
R4171 T14435 T14433 pobj Laboratory,from
R4172 T14436 T14435 compound Jackson,Laboratory
R4173 T14437 T14438 punct (,Harbor
R4174 T14438 T14435 parataxis Harbor,Laboratory
R4175 T14439 T14438 compound Bar,Harbor
R4176 T14440 T14438 punct ", ",Harbor
R4177 T14441 T14438 npadvmod Maine,Harbor
R4178 T14442 T14438 punct ", ",Harbor
R4179 T14443 T14444 compound United,States
R4180 T14444 T14438 npadvmod States,Harbor
R4181 T14445 T14438 punct ),Harbor
R4182 T14446 T14427 punct .,obtained
R4183 T14448 T14449 nsubj Mice,were
R4184 T14450 T14448 acl carrying,Mice
R4185 T14451 T14452 det a,mutation
R4186 T14452 T14450 dobj mutation,carrying
R4187 T14453 T14452 amod null,mutation
R4188 T14454 T14452 prep of,mutation
R4189 T14455 T14454 pobj Fog2,of
R4190 T14456 T14452 acl generated,mutation
R4191 T14457 T14456 prep by,generated
R4192 T14458 T14459 compound gene,targeting
R4193 T14459 T14457 pobj targeting,by
R4194 T14460 T14461 punct [,16
R4195 T14461 T14456 parataxis 16,generated
R4196 T14462 T14461 punct ],16
R4197 T14463 T14464 det the,gift
R4198 T14464 T14449 attr gift,were
R4199 T14465 T14464 amod generous,gift
R4200 T14466 T14464 prep of,gift
R4201 T14467 T14468 compound Dr.,Orkin
R4202 T14468 T14466 pobj Orkin,of
R4203 T14469 T14468 compound Stuart,Orkin
R4204 T14470 T14449 punct .,were
R4205 T15313 T15314 amod Developmental,analysis
R4206 T15315 T15314 prep of,analysis
R4207 T15316 T15315 pobj mice,of
R4208 T15317 T15314 punct .,analysis
R4209 T15319 T15320 amod Timed,pregnancies
R4210 T15320 T15321 nsubjpass pregnancies,set
R4211 T15322 T15321 auxpass were,set
R4212 T15323 T15321 prt up,set
R4213 T15324 T15321 prep for,set
R4214 T15325 T15324 pobj collection,for
R4215 T15326 T15325 prep of,collection
R4216 T15327 T15328 nmod E11.5,embryos
R4217 T15328 T15326 pobj embryos,of
R4218 T15329 T15330 punct –,E17.5
R4219 T15330 T15327 prep E17.5,E11.5
R4220 T15331 T15321 punct .,set
R4221 T15333 T15334 nsubj Embryos,fixed
R4222 T15335 T15334 aux were,fixed
R4223 T15336 T15334 punct ", ",fixed
R4224 T15337 T15334 conj dehydrated,fixed
R4225 T15338 T15337 punct ", ",dehydrated
R4226 T15339 T15337 cc and,dehydrated
R4227 T15340 T15337 conj embedded,dehydrated
R4228 T15341 T15340 prep in,embedded
R4229 T15342 T15341 pobj paraffin,in
R4230 T15343 T15344 amod prior,to
R4231 T15344 T15334 prep to,fixed
R4232 T15345 T15344 pobj sectioning,to
R4233 T15346 T15334 punct .,fixed
R4234 T15348 T15349 prep In,performed
R4235 T15350 T15351 amod older,embryos
R4236 T15351 T15348 pobj embryos,In
R4237 T15352 T15349 punct ", ",performed
R4238 T15353 T15354 det a,sternotomy
R4239 T15354 T15349 nsubjpass sternotomy,performed
R4240 T15355 T15354 amod median,sternotomy
R4241 T15356 T15349 auxpass was,performed
R4242 T15357 T15349 prep under,performed
R4243 T15358 T15359 amod microscopic,guidance
R4244 T15359 T15357 pobj guidance,under
R4245 T15360 T15349 punct ", ",performed
R4246 T15361 T15349 cc and,performed
R4247 T15362 T15363 nsubjpass diaphragm,examined
R4248 T15363 T15349 conj examined,performed
R4249 T15364 T15362 punct ", ",diaphragm
R4250 T15365 T15362 conj lungs,diaphragm
R4251 T15366 T15365 punct ", ",lungs
R4252 T15367 T15365 cc and,lungs
R4253 T15368 T15365 conj heart,lungs
R4254 T15369 T15363 auxpass were,examined
R4255 T15370 T15349 punct .,performed
R4256 T15372 T15373 det The,lungs
R4257 T15373 T15374 nsubjpass lungs,removed
R4258 T15375 T15373 cc and,lungs
R4259 T15376 T15377 amod tracheobronchial,tree
R4260 T15377 T15373 conj tree,lungs
R4261 T15378 T15374 auxpass were,removed
R4262 T15379 T15374 cc and,removed
R4263 T15380 T15374 conj weighed,removed
R4264 T15381 T15374 punct .,removed
R4265 T15383 T15384 amod Whole,diaphragms
R4266 T15384 T15385 nsubjpass diaphragms,isolated
R4267 T15386 T15385 auxpass were,isolated
R4268 T15387 T15385 prep from,isolated
R4269 T15388 T15389 amod fixed,tissue
R4270 T15389 T15387 pobj tissue,from
R4271 T15390 T15389 amod thoracic,tissue
R4272 T15391 T15389 prep from,tissue
R4273 T15392 T15393 nmod E15.5,embryos
R4274 T15393 T15391 pobj embryos,from
R4275 T15394 T15392 cc and,E15.5
R4276 T15395 T15392 conj E17.5,E15.5
R4277 T15396 T15385 punct .,isolated
R4278 T15398 T15399 prep For,dissected
R4279 T15400 T15401 compound lung,culture
R4280 T15401 T15398 pobj culture,For
R4281 T15402 T15401 compound explant,culture
R4282 T15403 T15399 punct ", ",dissected
R4283 T15404 T15399 nsubjpass lungs,dissected
R4284 T15405 T15399 auxpass were,dissected
R4285 T15406 T15399 prep from,dissected
R4286 T15407 T15408 amod fresh,embryos
R4287 T15408 T15406 pobj embryos,from
R4288 T15409 T15399 prep at,dissected
R4289 T15410 T15409 pobj E11.5,at
R4290 T15411 T15410 cc and,E11.5
R4291 T15412 T15410 conj E12.5,E11.5
R4292 T15413 T15399 cc and,dissected
R4293 T15414 T15399 conj placed,dissected
R4294 T15415 T15414 prep on,placed
R4295 T15416 T15417 amod porous,membranes
R4296 T15417 T15415 pobj membranes,on
R4297 T15418 T15419 nummod 24,mm
R4298 T15419 T15417 nmod mm,membranes
R4299 T15420 T15419 punct -,mm
R4300 T15421 T15422 punct (,μ
R4301 T15422 T15417 parataxis μ,membranes
R4302 T15423 T15422 nummod 0.4,μ
R4303 T15424 T15422 punct -,μ
R4304 T15425 T15422 punct ),μ
R4305 T15426 T15417 compound polyester,membranes
R4306 T15427 T15417 acl floated,membranes
R4307 T15428 T15427 prep in,floated
R4308 T15429 T15428 pobj wells,in
R4309 T15430 T15429 acl containing,wells
R4310 T15431 T15432 nummod 2,ml
R4311 T15432 T15430 dobj ml,containing
R4312 T15433 T15432 prep of,ml
R4313 T15434 T15435 poss Dulbecco,medium
R4314 T15435 T15433 pobj medium,of
R4315 T15436 T15434 case 's,Dulbecco
R4316 T15437 T15435 amod modified,medium
R4317 T15438 T15435 poss Eagle,medium
R4318 T15439 T15438 case 's,Eagle
R4319 T15440 T15435 punct ", ",medium
R4320 T15441 T15442 compound nutrient,mixture
R4321 T15442 T15443 compound mixture,F
R4322 T15443 T15435 appos F,medium
R4323 T15444 T15443 punct -,F
R4324 T15445 T15443 nummod 12,F
R4325 T15446 T15447 punct (,Gibco
R4326 T15447 T15443 parataxis Gibco,F
R4327 T15448 T15449 nummod 11039,021
R4328 T15449 T15447 dep 021,Gibco
R4329 T15450 T15449 punct –,021
R4330 T15451 T15447 punct ", ",Gibco
R4331 T15452 T15447 punct ", ",Gibco
R4332 T15453 T15454 compound San,Diego
R4333 T15454 T15447 npadvmod Diego,Gibco
R4334 T15455 T15447 punct ", ",Gibco
R4335 T15456 T15447 npadvmod California,Gibco
R4336 T15457 T15447 punct ", ",Gibco
R4337 T15458 T15459 compound United,States
R4338 T15459 T15447 npadvmod States,Gibco
R4339 T15460 T15447 punct ),Gibco
R4340 T15461 T15435 punct ", ",medium
R4341 T15462 T15435 acl supplemented,medium
R4342 T15463 T15462 prep with,supplemented
R4343 T15464 T15465 nummod 10,%
R4344 T15465 T15466 nmod %,serum
R4345 T15466 T15463 pobj serum,with
R4346 T15467 T15466 amod fetal,serum
R4347 T15468 T15466 amod bovine,serum
R4348 T15469 T15466 punct ", ",serum
R4349 T15470 T15471 nummod 0.3,mg
R4350 T15471 T15472 nmod mg,glutamine
R4351 T15472 T15466 conj glutamine,serum
R4352 T15473 T15474 punct /,ml
R4353 T15474 T15471 prep ml,mg
R4354 T15475 T15472 compound L,glutamine
R4355 T15476 T15472 punct -,glutamine
R4356 T15477 T15472 punct ", ",glutamine
R4357 T15478 T15479 nummod 100,units
R4358 T15479 T15480 nmod units,penicillin
R4359 T15480 T15472 conj penicillin,glutamine
R4360 T15481 T15482 punct /,ml
R4361 T15482 T15479 prep ml,units
R4362 T15483 T15480 punct ", ",penicillin
R4363 T15484 T15485 nummod 100,mcg
R4364 T15485 T15486 nmod mcg,streptomycin
R4365 T15486 T15480 conj streptomycin,penicillin
R4366 T15487 T15488 punct /,ml
R4367 T15488 T15485 prep ml,mcg
R4368 T15489 T15486 punct ", ",streptomycin
R4369 T15490 T15486 cc and,streptomycin
R4370 T15491 T15492 nummod 0.25,mcg
R4371 T15492 T15493 nmod mcg,B
R4372 T15493 T15486 conj B,streptomycin
R4373 T15494 T15495 punct /,ml
R4374 T15495 T15492 prep ml,mcg
R4375 T15496 T15493 compound amphotericin,B
R4376 T15497 T15399 punct .,dissected
R4377 T15499 T15500 compound Lung,explants
R4378 T15500 T15501 nsubjpass explants,cultured
R4379 T15502 T15501 auxpass were,cultured
R4380 T15503 T15501 prep at,cultured
R4381 T15504 T15505 nummod 37,°C
R4382 T15505 T15503 pobj °C,at
R4383 T15506 T15501 prep in,cultured
R4384 T15507 T15508 nummod 95,%
R4385 T15508 T15509 compound %,air
R4386 T15509 T15506 pobj air,in
R4387 T15510 T15509 punct /,air
R4388 T15511 T15512 nummod 5,%
R4389 T15512 T15513 compound %,CO2
R4390 T15513 T15509 appos CO2,air
R4391 T15514 T15501 prep for,cultured
R4392 T15515 T15516 advmod up,5
R4393 T15516 T15518 nummod 5,d
R4394 T15517 T15516 quantmod to,5
R4395 T15518 T15514 pobj d,for
R4396 T15519 T15501 punct .,cultured
R4397 T15521 T15522 nsubjpass They,photographed
R4398 T15523 T15522 auxpass were,photographed
R4399 T15524 T15522 advmod daily,photographed
R4400 T15525 T15522 prep with,photographed
R4401 T15526 T15527 det a,microscope
R4402 T15527 T15525 pobj microscope,with
R4403 T15528 T15527 amod dissecting,microscope
R4404 T15529 T15530 punct (,MZ12.5
R4405 T15530 T15527 parataxis MZ12.5,microscope
R4406 T15531 T15530 punct ", ",MZ12.5
R4407 T15532 T15530 npadvmod Leica,MZ12.5
R4408 T15533 T15530 punct ", ",MZ12.5
R4409 T15534 T15530 npadvmod Wetzlar,MZ12.5
R4410 T15535 T15530 punct ", ",MZ12.5
R4411 T15536 T15530 npadvmod Germany,MZ12.5
R4412 T15537 T15530 punct ),MZ12.5
R4413 T15538 T15527 acl equipped,microscope
R4414 T15539 T15538 prep with,equipped
R4415 T15540 T15541 det a,camera
R4416 T15541 T15539 pobj camera,with
R4417 T15542 T15543 nmod Leica,DC500
R4418 T15543 T15541 nmod DC500,camera
R4419 T15544 T15541 amod digital,camera
R4420 T15545 T15522 punct .,photographed
R4421 T15547 T15548 amod Transgenic,mice
R4422 T15548 T15549 nsubjpass mice,developed
R4423 T15550 T15548 acl carrying,mice
R4424 T15551 T15552 det the,gene
R4425 T15552 T15550 dobj gene,carrying
R4426 T15553 T15552 compound lacZ,gene
R4427 T15554 T15552 acl driven,gene
R4428 T15555 T15554 agent by,driven
R4429 T15556 T15557 det the,promoter
R4430 T15557 T15555 pobj promoter,by
R4431 T15558 T15557 compound Fog2,promoter
R4432 T15559 T15549 aux have,developed
R4433 T15560 T15549 auxpass been,developed
R4434 T15561 T15549 agent by,developed
R4435 T15562 T15563 compound S.,Tevosian
R4436 T15563 T15561 pobj Tevosian,by
R4437 T15564 T15549 punct .,developed
R4438 T15566 T15567 prep In,incorporated
R4439 T15568 T15569 det these,animals
R4440 T15569 T15566 pobj animals,In
R4441 T15570 T15567 punct ", ",incorporated
R4442 T15571 T15572 det the,gene
R4443 T15572 T15567 nsubjpass gene,incorporated
R4444 T15573 T15572 compound lacZ,gene
R4445 T15574 T15567 auxpass is,incorporated
R4446 T15575 T15576 punct (,knocked
R4447 T15576 T15567 parataxis knocked,incorporated
R4448 T15577 T15576 punct “,knocked
R4449 T15578 T15576 punct -,knocked
R4450 T15579 T15576 prt in,knocked
R4451 T15580 T15576 punct ”,knocked
R4452 T15581 T15576 punct ),knocked
R4453 T15582 T15567 prep into,incorporated
R4454 T15583 T15584 det the,locus
R4455 T15584 T15582 pobj locus,into
R4456 T15585 T15584 compound Fog2,locus
R4457 T15586 T15587 aux to,allow
R4458 T15587 T15567 advcl allow,incorporated
R4459 T15588 T15589 compound β,galactosidase
R4460 T15589 T15591 compound galactosidase,expression
R4461 T15590 T15589 punct -,galactosidase
R4462 T15591 T15587 dobj expression,allow
R4463 T15592 T15587 prep as,allow
R4464 T15593 T15594 det a,protein
R4465 T15594 T15592 pobj protein,as
R4466 T15595 T15594 compound fusion,protein
R4467 T15596 T15594 prep in,protein
R4468 T15597 T15596 pobj frame,in
R4469 T15598 T15597 prep with,frame
R4470 T15599 T15600 det the,acids
R4471 T15600 T15598 pobj acids,with
R4472 T15601 T15600 amod first,acids
R4473 T15602 T15600 nummod 235,acids
R4474 T15603 T15600 compound amino,acids
R4475 T15604 T15600 prep of,acids
R4476 T15605 T15606 det the,protein
R4477 T15606 T15604 pobj protein,of
R4478 T15607 T15606 compound FOG2,protein
R4479 T15608 T15567 punct .,incorporated
R4480 T15610 T15611 det The,module
R4481 T15611 T15615 nsubjpass module,followed
R4482 T15612 T15613 compound Fog2,lacZ
R4483 T15613 T15611 compound lacZ,module
R4484 T15614 T15613 punct -,lacZ
R4485 T15616 T15615 auxpass is,followed
R4486 T15617 T15615 agent by,followed
R4487 T15618 T15619 det an,cassette
R4488 T15619 T15617 pobj cassette,by
R4489 T15620 T15621 compound ires,eGFP
R4490 T15621 T15619 compound eGFP,cassette
R4491 T15622 T15621 punct -,eGFP
R4492 T15623 T15615 punct .,followed
R4493 T15625 T15626 nsubj This,creates
R4494 T15627 T15628 det a,allele
R4495 T15628 T15626 dobj allele,creates
R4496 T15629 T15628 amod null,allele
R4497 T15630 T15628 prep of,allele
R4498 T15631 T15632 compound Fog2,gene
R4499 T15632 T15630 pobj gene,of
R4500 T15633 T15626 punct .,creates
R4501 T15635 T15636 det The,construct
R4502 T15636 T15642 nsubjpass construct,linearized
R4503 T15637 T15638 compound Fog2,eGFP
R4504 T15638 T15636 compound eGFP,construct
R4505 T15639 T15638 punct -,eGFP
R4506 T15640 T15638 compound LacZ,eGFP
R4507 T15641 T15638 punct -,eGFP
R4508 T15643 T15642 auxpass was,linearized
R4509 T15644 T15642 prep with,linearized
R4510 T15645 T15644 pobj KspI,with
R4511 T15646 T15642 cc and,linearized
R4512 T15647 T15642 conj electroporated,linearized
R4513 T15648 T15647 prep into,electroporated
R4514 T15649 T15650 det the,cells
R4515 T15650 T15648 pobj cells,into
R4516 T15651 T15650 compound CJ7,cells
R4517 T15652 T15650 compound ES,cells
R4518 T15653 T15642 punct .,linearized
R4519 T15655 T15656 det The,clone
R4520 T15656 T15659 nsubjpass clone,selected
R4521 T15657 T15658 advmod correctly,targeted
R4522 T15658 T15656 amod targeted,clone
R4523 T15660 T15659 auxpass was,selected
R4524 T15661 T15659 prep by,selected
R4525 T15662 T15663 det the,analysis
R4526 T15663 T15661 pobj analysis,by
R4527 T15664 T15665 compound Southern,blot
R4528 T15665 T15663 compound blot,analysis
R4529 T15666 T15659 cc and,selected
R4530 T15667 T15659 conj injected,selected
R4531 T15668 T15667 prep into,injected
R4532 T15669 T15670 compound C57BL,6J
R4533 T15670 T15672 compound 6J,blastocysts
R4534 T15671 T15670 punct /,6J
R4535 T15672 T15668 pobj blastocysts,into
R4536 T15673 T15659 punct .,selected
R4537 T15675 T15676 compound Fog2,eGFP
R4538 T15676 T15680 compound eGFP,animals
R4539 T15677 T15676 punct -,eGFP
R4540 T15678 T15676 compound lacZ,eGFP
R4541 T15679 T15676 punct -,eGFP
R4542 T15680 T15681 nsubjpass animals,maintained
R4543 T15682 T15681 auxpass were,maintained
R4544 T15683 T15681 prep on,maintained
R4545 T15684 T15685 det the,background
R4546 T15685 T15683 pobj background,on
R4547 T15686 T15685 amod mixed,background
R4548 T15687 T15688 nmod C57BL,6J
R4549 T15688 T15685 nmod 6J,background
R4550 T15689 T15688 punct /,6J
R4551 T15690 T15688 punct /,6J
R4552 T15691 T15688 nummod 129,6J
R4553 T15692 T15681 punct .,maintained
R4554 T15694 T15695 compound lacZ,Expression
R4555 T15695 T15696 nsubjpass Expression,analyzed
R4556 T15697 T15695 prep in,Expression
R4557 T15698 T15699 amod whole,lungs
R4558 T15699 T15697 pobj lungs,in
R4559 T15700 T15699 amod dissected,lungs
R4560 T15701 T15699 amod embryonic,lungs
R4561 T15702 T15696 auxpass was,analyzed
R4562 T15703 T15696 prep by,analyzed
R4563 T15704 T15703 pcomp staining,by
R4564 T15705 T15704 prep for,staining
R4565 T15706 T15707 compound β,galactosidase
R4566 T15707 T15709 compound galactosidase,activity
R4567 T15708 T15707 punct -,galactosidase
R4568 T15709 T15705 pobj activity,for
R4569 T15710 T15704 prep with,staining
R4570 T15711 T15712 compound X,gal
R4571 T15712 T15710 pobj gal,with
R4572 T15713 T15712 punct -,gal
R4573 T15714 T15704 prep after,staining
R4574 T15715 T15714 pobj fixation,after
R4575 T15716 T15715 prep for,fixation
R4576 T15717 T15718 nummod 30,min
R4577 T15718 T15716 pobj min,for
R4578 T15719 T15696 punct .,analyzed
R4581 T16000 T16001 compound RT,PCR
R4582 T16002 T16001 punct -,PCR
R4583 T16003 T16001 cc and,PCR
R4584 T16004 T16005 compound sequence,analysis
R4585 T16005 T16001 conj analysis,PCR
R4586 T16006 T16001 prep in,PCR
R4587 T16007 T16008 det the,mouse
R4588 T16008 T16006 pobj mouse,in
R4589 T16009 T16001 punct .,PCR
R4590 T16011 T16012 nsubjpass RNA,extracted
R4591 T16013 T16012 auxpass was,extracted
R4592 T16014 T16012 prep by,extracted
R4593 T16015 T16016 amod standard,techniques
R4594 T16016 T16014 pobj techniques,by
R4595 T16017 T16012 prep from,extracted
R4596 T16018 T16019 amod thoracic,tissue
R4597 T16019 T16017 pobj tissue,from
R4598 T16020 T16019 amod embryonic,tissue
R4599 T16021 T16012 punct .,extracted
R4600 T16023 T16024 compound RT,PCR
R4601 T16024 T16026 nsubjpass PCR,performed
R4602 T16025 T16024 punct -,PCR
R4603 T16027 T16026 auxpass was,performed
R4604 T16028 T16026 advcl using,performed
R4605 T16029 T16030 nummod six,sets
R4606 T16030 T16028 dobj sets,using
R4607 T16031 T16030 compound primer,sets
R4608 T16032 T16030 acl designed,sets
R4609 T16033 T16034 aux to,cover
R4610 T16034 T16032 advcl cover,designed
R4611 T16035 T16036 det the,gene
R4612 T16036 T16034 dobj gene,cover
R4613 T16037 T16036 compound Fog2,gene
R4614 T16038 T16026 punct .,performed
R4615 T16040 T16041 compound RT,PCR
R4616 T16041 T16043 nsubjpass PCR,repeated
R4617 T16042 T16041 punct -,PCR
R4618 T16044 T16043 auxpass was,repeated
R4619 T16045 T16043 prep with,repeated
R4620 T16046 T16047 amod radiolabeled,primers
R4621 T16047 T16045 pobj primers,with
R4622 T16048 T16049 aux to,amplify
R4623 T16049 T16043 advcl amplify,repeated
R4624 T16050 T16051 det an,region
R4625 T16051 T16049 dobj region,amplify
R4626 T16052 T16053 advmod abnormally,spliced
R4627 T16053 T16051 amod spliced,region
R4628 T16054 T16051 prep of,region
R4629 T16055 T16056 det the,gene
R4630 T16056 T16054 pobj gene,of
R4631 T16057 T16058 punct (,S1
R4632 T16058 T16043 parataxis S1,repeated
R4633 T16059 T16058 compound Table,S1
R4634 T16060 T16058 punct ),S1
R4635 T16061 T16043 punct ", ",repeated
R4636 T16062 T16043 cc and,repeated
R4637 T16063 T16064 det the,product
R4638 T16064 T16065 nsubjpass product,run
R4639 T16065 T16043 conj run,repeated
R4640 T16066 T16065 auxpass was,run
R4641 T16067 T16065 prep on,run
R4642 T16068 T16069 det a,gel
R4643 T16069 T16067 pobj gel,on
R4644 T16070 T16069 amod denaturing,gel
R4645 T16071 T16069 compound sequencing,gel
R4646 T16072 T16065 prep according,run
R4647 T16073 T16072 prep to,according
R4648 T16074 T16075 amod standard,techniques
R4649 T16075 T16073 pobj techniques,to
R4650 T16076 T16065 punct .,run
R4651 T16078 T16079 det The,product
R4652 T16079 T16083 nsubjpass product,cloned
R4653 T16080 T16081 compound RT,PCR
R4654 T16081 T16079 compound PCR,product
R4655 T16082 T16081 punct -,PCR
R4656 T16084 T16083 auxpass was,cloned
R4657 T16085 T16083 prep into,cloned
R4658 T16086 T16087 compound pCR2.1,vector
R4659 T16087 T16085 pobj vector,into
R4660 T16088 T16083 advcl using,cloned
R4661 T16089 T16090 compound TOPO,Kit
R4662 T16090 T16088 dobj Kit,using
R4663 T16091 T16090 compound TA,Kit
R4664 T16092 T16090 compound Cloning,Kit
R4665 T16093 T16094 punct (,Invitrogen
R4666 T16094 T16090 parataxis Invitrogen,Kit
R4667 T16095 T16094 punct ", ",Invitrogen
R4668 T16096 T16094 npadvmod Carlsbad,Invitrogen
R4669 T16097 T16094 punct ", ",Invitrogen
R4670 T16098 T16094 npadvmod California,Invitrogen
R4671 T16099 T16094 punct ", ",Invitrogen
R4672 T16100 T16101 compound United,States
R4673 T16101 T16094 npadvmod States,Invitrogen
R4674 T16102 T16094 punct ),Invitrogen
R4675 T16103 T16083 cc and,cloned
R4676 T16104 T16083 conj sequenced,cloned
R4677 T16105 T16104 advcl using,sequenced
R4678 T16106 T16107 npadvmod gene,specific
R4679 T16107 T16109 amod specific,primers
R4680 T16108 T16107 punct -,specific
R4681 T16109 T16105 dobj primers,using
R4682 T16110 T16083 punct .,cloned
R4683 T16112 T16113 compound Sequence,analysis
R4684 T16113 T16114 nsubjpass analysis,done
R4685 T16115 T16114 auxpass was,done
R4686 T16116 T16114 advcl using,done
R4687 T16117 T16116 dobj Sequencher,using
R4688 T16118 T16117 nummod 4.1,Sequencher
R4689 T16119 T16120 punct (,Codes
R4690 T16120 T16117 parataxis Codes,Sequencher
R4691 T16121 T16120 compound Gene,Codes
R4692 T16122 T16120 punct ", ",Codes
R4693 T16123 T16124 compound Ann,Arbor
R4694 T16124 T16120 npadvmod Arbor,Codes
R4695 T16125 T16120 punct ", ",Codes
R4696 T16126 T16120 npadvmod Michigan,Codes
R4697 T16127 T16120 punct ", ",Codes
R4698 T16128 T16129 compound United,States
R4699 T16129 T16120 npadvmod States,Codes
R4700 T16130 T16120 punct ),Codes
R4701 T16131 T16114 punct .,done
R4702 T16289 T16290 advmod In,situ
R4703 T16290 T16291 amod situ,hybridization
R4704 T16292 T16291 punct .,hybridization
R4705 T16294 T16295 prep After,subjected
R4706 T16296 T16294 pobj dehydration,After
R4707 T16297 T16296 cc and,dehydration
R4708 T16298 T16296 conj embedding,dehydration
R4709 T16299 T16298 prep in,embedding
R4710 T16300 T16301 compound paraffin,wax
R4711 T16301 T16299 pobj wax,in
R4712 T16302 T16295 punct ", ",subjected
R4713 T16303 T16304 nummod 10,μ
R4714 T16304 T16306 compound μ,sections
R4715 T16305 T16304 punct -,μ
R4716 T16306 T16295 nsubjpass sections,subjected
R4717 T16307 T16295 auxpass were,subjected
R4718 T16308 T16295 prep to,subjected
R4719 T16309 T16310 amod radioactive,hybridization
R4720 T16310 T16308 pobj hybridization,to
R4721 T16311 T16312 advmod in,situ
R4722 T16312 T16310 amod situ,hybridization
R4723 T16313 T16314 mark as,described
R4724 T16314 T16295 advcl described,subjected
R4725 T16315 T16316 punct [,53
R4726 T16316 T16295 parataxis 53,subjected
R4727 T16317 T16316 punct ],53
R4728 T16318 T16295 punct .,subjected
R4729 T16320 T16321 nsubjpass Probes,prepared
R4730 T16322 T16320 acl labeled,Probes
R4731 T16323 T16322 prep with,labeled
R4732 T16324 T16323 pobj 35S,with
R4733 T16325 T16321 auxpass were,prepared
R4734 T16326 T16321 prep by,prepared
R4735 T16327 T16328 amod run,transcription
R4736 T16328 T16326 pobj transcription,by
R4737 T16329 T16327 punct -,run
R4738 T16330 T16327 prt off,run
R4739 T16331 T16328 prep of,transcription
R4740 T16332 T16333 amod linearized,templates
R4741 T16333 T16331 pobj templates,of
R4742 T16334 T16333 compound plasmid,templates
R4743 T16335 T16321 cc and,prepared
R4744 T16336 T16321 conj hybridized,prepared
R4745 T16337 T16336 prep to,hybridized
R4746 T16338 T16339 compound tissue,sections
R4747 T16339 T16337 pobj sections,to
R4748 T16340 T16321 punct .,prepared
R4749 T16342 T16343 nsubjpass Nuclei,counterstained
R4750 T16344 T16343 auxpass were,counterstained
R4751 T16345 T16343 prep with,counterstained
R4752 T16346 T16345 pobj Hoescht,with
R4753 T16347 T16346 nummod 33258,Hoescht
R4754 T16348 T16343 punct ", ",counterstained
R4755 T16349 T16343 cc and,counterstained
R4756 T16350 T16351 nsubjpass signal,imaged
R4757 T16351 T16343 conj imaged,counterstained
R4758 T16352 T16351 auxpass was,imaged
R4759 T16353 T16351 advcl using,imaged
R4760 T16354 T16355 amod fluorescent,microscopy
R4761 T16355 T16353 dobj microscopy,using
R4762 T16356 T16354 cc and,fluorescent
R4763 T16357 T16354 conj darkfield,fluorescent
R4764 T16358 T16351 punct .,imaged
R4765 T16688 T16689 amod Human,extraction
R4766 T16690 T16689 compound DNA,extraction
R4767 T16691 T16689 cc and,extraction
R4768 T16692 T16693 compound sequence,analysis
R4769 T16693 T16689 conj analysis,extraction
R4770 T16694 T16693 punct .,analysis
R4771 T16696 T16697 nsubjpass DNA,isolated
R4772 T16698 T16697 auxpass was,isolated
R4773 T16699 T16697 prep from,isolated
R4774 T16700 T16701 compound paraffin,blocks
R4775 T16701 T16699 pobj blocks,from
R4776 T16702 T16697 prep by,isolated
R4777 T16703 T16704 compound phenol,chloroform
R4778 T16704 T16706 compound chloroform,extraction
R4779 T16705 T16704 punct -,chloroform
R4780 T16706 T16702 pobj extraction,by
R4781 T16707 T16708 punct [,55
R4782 T16708 T16697 parataxis 55,isolated
R4783 T16709 T16708 nummod 54,55
R4784 T16710 T16708 punct ",",55
R4785 T16711 T16708 punct ],55
R4786 T16712 T16697 punct ", ",isolated
R4787 T16713 T16697 cc and,isolated
R4788 T16714 T16697 conj from,isolated
R4789 T16715 T16716 amod frozen,tissues
R4790 T16716 T16714 pobj tissues,from
R4791 T16717 T16714 prep by,from
R4792 T16718 T16719 amod standard,techniques
R4793 T16719 T16717 pobj techniques,by
R4794 T16720 T16697 punct .,isolated
R4795 T16722 T16723 nsubjpass Primers,designed
R4796 T16724 T16723 auxpass were,designed
R4797 T16725 T16726 aux to,amplify
R4798 T16726 T16723 advcl amplify,designed
R4799 T16727 T16728 compound FOG2,exons
R4800 T16728 T16726 dobj exons,amplify
R4801 T16729 T16728 compound coding,exons
R4802 T16730 T16728 cc plus,exons
R4803 T16731 T16732 nummod 50,bp
R4804 T16732 T16728 conj bp,exons
R4805 T16733 T16732 prep of,bp
R4806 T16734 T16735 amod flanking,sequence
R4807 T16735 T16733 pobj sequence,of
R4808 T16736 T16735 amod upstream,sequence
R4809 T16737 T16736 cc and,upstream
R4810 T16738 T16736 conj downstream,upstream
R4811 T16739 T16723 punct .,designed
R4812 T16741 T16742 compound PCR,amplification
R4813 T16742 T16743 nsubjpass amplification,performed
R4814 T16744 T16742 cc and,amplification
R4815 T16745 T16742 conj sequencing,amplification
R4816 T16746 T16743 auxpass were,performed
R4817 T16747 T16743 prep by,performed
R4818 T16748 T16749 amod standard,methods
R4819 T16749 T16747 pobj methods,by
R4820 T16750 T16743 punct .,performed
R4821 T16752 T16753 compound Primer,sequences
R4822 T16753 T16754 nsubjpass sequences,listed
R4823 T16755 T16753 acl used,sequences
R4824 T16756 T16754 auxpass are,listed
R4825 T16757 T16754 prep in,listed
R4826 T16758 T16759 compound Table,S2
R4827 T16759 T16757 pobj S2,in
R4828 T16760 T16754 punct .,listed
R4829 T16762 T16763 compound Sequence,analysis
R4830 T16763 T16764 nsubjpass analysis,done
R4831 T16765 T16764 auxpass was,done
R4832 T16766 T16764 prep with,done
R4833 T16767 T16766 pobj Sequencher,with
R4834 T16768 T16767 nummod 4.1,Sequencher
R4835 T16769 T16770 punct (,Codes
R4836 T16770 T16767 parataxis Codes,Sequencher
R4837 T16771 T16770 compound Gene,Codes
R4838 T16772 T16770 punct ),Codes
R4839 T16773 T16764 punct .,done
R4840 T16775 T16776 nsubjpass DNA,extracted
R4841 T16777 T16775 prep from,DNA
R4842 T16778 T16779 det the,parents
R4843 T16779 T16777 pobj parents,from
R4844 T16780 T16779 prep of,parents
R4845 T16781 T16782 nummod one,patient
R4846 T16782 T16780 pobj patient,of
R4847 T16783 T16782 compound autopsy,patient
R4848 T16784 T16776 auxpass was,extracted
R4849 T16785 T16776 prep from,extracted
R4850 T16786 T16787 amod fresh,samples
R4851 T16787 T16785 pobj samples,from
R4852 T16788 T16787 compound blood,samples
R4853 T16789 T16776 punct .,extracted
R4854 T16791 T16792 det A,set
R4855 T16792 T16794 nsubjpass set,sent
R4856 T16793 T16792 amod second,set
R4857 T16795 T16792 prep of,set
R4858 T16796 T16797 compound blood,samples
R4859 T16797 T16795 pobj samples,of
R4860 T16798 T16794 auxpass was,sent
R4861 T16799 T16794 prep to,sent
R4862 T16800 T16801 det an,laboratory
R4863 T16801 T16799 pobj laboratory,to
R4864 T16802 T16801 amod outside,laboratory
R4865 T16803 T16804 npadvmod CLIA,certified
R4866 T16804 T16801 amod certified,laboratory
R4867 T16805 T16804 punct -,certified
R4868 T16806 T16794 prep for,sent
R4869 T16807 T16808 compound DNA,extraction
R4870 T16808 T16806 pobj extraction,for
R4871 T16809 T16808 punct ", ",extraction
R4872 T16810 T16808 conj PCR,extraction
R4873 T16811 T16810 punct ", ",PCR
R4874 T16812 T16810 conj sequencing,PCR
R4875 T16813 T16812 punct ", ",sequencing
R4876 T16814 T16812 cc and,sequencing
R4877 T16815 T16812 conj analysis,sequencing
R4878 T16816 T16794 punct .,sent
R4879 T16818 T16819 compound Paternity,testing
R4880 T16819 T16820 nsubjpass testing,performed
R4881 T16821 T16820 auxpass was,performed
R4882 T16822 T16820 agent by,performed
R4883 T16823 T16824 det the,laboratory
R4884 T16824 T16822 pobj laboratory,by
R4885 T16825 T16824 amod outside,laboratory
R4886 T16826 T16820 advcl using,performed
R4887 T16827 T16828 det a,panel
R4888 T16828 T16826 dobj panel,using
R4889 T16829 T16828 amod standard,panel
R4890 T16830 T16828 prep of,panel
R4891 T16831 T16830 pobj markers,of
R4892 T16832 T16820 punct .,performed
R4893 T16834 T16835 compound SNP,genotyping
R4894 T16835 T16836 nsubjpass genotyping,done
R4895 T16837 T16836 auxpass was,done
R4896 T16838 T16836 advcl using,done
R4897 T16839 T16840 nmod Harvard,Center
R4898 T16840 T16842 nmod Center,facility
R4899 T16841 T16840 nmod Partners,Center
R4900 T16842 T16838 dobj facility,using
R4901 T16843 T16840 prep for,Center
R4902 T16844 T16843 pobj Genetics,for
R4903 T16845 T16844 cc and,Genetics
R4904 T16846 T16844 conj Genomics,Genetics
R4905 T16847 T16842 compound genotyping,facility
R4906 T16848 T16842 compound core,facility
R4907 T16849 T16850 punct (,Cambridge
R4908 T16850 T16842 parataxis Cambridge,facility
R4909 T16851 T16850 punct ", ",Cambridge
R4910 T16852 T16850 npadvmod Massachusetts,Cambridge
R4911 T16853 T16850 punct ", ",Cambridge
R4912 T16854 T16855 compound United,States
R4913 T16855 T16850 npadvmod States,Cambridge
R4914 T16856 T16850 punct ),Cambridge
R4915 T16857 T16836 punct .,done
R45 T1050 T1049 prep of,analysis
R42 T1046 T1047 prep In,identified
R43 T1048 T1049 det an,analysis
R44 T1049 T1046 pobj analysis,In
R15 T1016 T1018 nsubj hernia,are
R22 T1025 T1018 acomp associated,are
R23 T1026 T1025 prep with,associated
R24 T1027 T1028 amod significant,mortality
R25 T1028 T1026 pobj mortality,with
R26 T1029 T1028 cc and,mortality
R27 T1030 T1028 conj morbidity,mortality
R28 T1031 T1018 prep in,are
R29 T1032 T1031 pobj neonates,in
R30 T1033 T1024 punct ;,is
R31 T1034 T1024 advmod however,is
R32 T1035 T1024 punct ", ",is
R33 T1036 T1037 det the,basis
R36 T1039 T1037 prep of,basis
R37 T1040 T1041 det these,anomalies
R40 T1043 T1024 acomp unknown,is
R41 T1044 T1024 punct .,is
R46 T1051 T1052 compound E18.5,embryos
R47 T1052 T1050 pobj embryos,of
R48 T1053 T1052 acl derived,embryos
R49 T1054 T1053 prep from,derived
R50 T1055 T1054 pobj mice,from
R51 T1056 T1055 acl treated,mice
R52 T1057 T1056 prep with,treated
R53 T1058 T1059 compound N,ethyl
R56 T1061 T1059 punct -,ethyl
R57 T1062 T1063 compound N,nitrosourea
R60 T1065 T1047 punct ", ",identified
R61 T1066 T1047 nsubj we,identified
R62 T1067 T1068 det a,mutation
R63 T1068 T1047 dobj mutation,identified
R64 T1069 T1070 dep that,causes
R65 T1070 T1068 relcl causes,mutation
R66 T1071 T1072 amod pulmonary,hypoplasia
R67 T1072 T1070 dobj hypoplasia,causes
R68 T1073 T1072 cc and,hypoplasia
R69 T1074 T1075 amod abnormal,development
R72 T1077 T1047 punct .,identified
R73 T1079 T1080 nsubj Fog2,maps
R74 T1081 T1082 punct (,Zfpm2
R75 T1082 T1079 parataxis Zfpm2,Fog2
R76 T1083 T1082 punct ),Zfpm2
R77 T1084 T1080 prep within,maps
R78 T1085 T1086 det the,interval
R81 T1088 T1086 acl carrying,interval
R82 T1089 T1090 det the,mutation
R85 T1092 T1094 npadvmod ethyl,induced
R93 T1100 T1080 punct ", ",maps
R94 T1101 T1080 cc and,maps
R95 T1102 T1103 compound DNA,sequencing
R96 T1103 T1104 nsubj sequencing,identified
R100 T1107 T1108 det a,mutation
R101 T1108 T1104 dobj mutation,identified
R102 T1109 T1104 prep in,identified
R103 T1110 T1111 det a,site
R107 T1114 T1115 dep that,generates
R108 T1115 T1111 relcl generates,site
R109 T1116 T1117 det an,transcript
R112 T1119 T1117 acl encoding,transcript
R113 T1120 T1121 det a,protein
R116 T1123 T1104 punct .,identified
R117 T1125 T1126 amod Human,cases
R120 T1129 T1126 prep with,cases
R121 T1130 T1131 amod diaphragmatic,defect
R122 T1131 T1129 pobj defect,with
R123 T1132 T1131 cc and,defect
R124 T1133 T1134 amod pulmonary,hypoplasia
R125 T1134 T1131 conj hypoplasia,defect
R126 T1135 T1128 auxpass were,evaluated
R127 T1136 T1128 prep for,evaluated
R128 T1137 T1136 pobj mutations,for
R129 T1138 T1137 prep in,mutations
R130 T1139 T1138 pobj FOG2,in
R131 T1140 T1128 punct .,evaluated
R132 T1142 T1143 compound Sequence,analysis
R133 T1143 T1144 nsubj analysis,revealed
R134 T1145 T1146 det a,mutation
R138 T1149 T1146 acl resulting,mutation
R139 T1150 T1149 prep in,resulting
R140 T1151 T1152 det a,codon
R144 T1155 T1152 prep in,codon
R145 T1156 T1157 det a,child
R146 T1157 T1155 pobj child,in
R147 T1158 T1159 dep who,died
R148 T1159 T1157 relcl died,child
R149 T1160 T1159 prep on,died
R150 T1161 T1162 det the,day
R153 T1164 T1162 prep of,day
R154 T1165 T1164 pobj life,of
R155 T1166 T1152 amod secondary,codon
R156 T1167 T1166 prep to,secondary
R157 T1168 T1169 amod severe,hypoplasia
R161 T1172 T1169 cc and,hypoplasia
R162 T1173 T1174 det an,diaphragm
R166 T1177 T1144 punct .,revealed
R167 T1179 T1180 advcl Using,established
R168 T1181 T1182 det a,approach
R171 T1184 T1182 amod driven,approach
R173 T1186 T1180 punct ", ",established
R174 T1187 T1180 nsubj we,established
R175 T1188 T1180 aux have,established
R176 T1189 T1190 mark that,required
R180 T1193 T1190 prep for,required
R181 T1194 T1195 amod normal,development
R186 T1199 T1190 punct ", ",required
R187 T1200 T1201 det a,role
R188 T1201 T1190 npadvmod role,required
R189 T1202 T1203 dep that,appreciated
R195 T1208 T1180 punct .,established
R196 T1210 T1211 nsubj FOG2,is
R197 T1212 T1213 det the,gene
R200 T1215 T1213 acl implicated,gene
R201 T1216 T1215 prep in,implicated
R202 T1217 T1218 det the,pathogenesis
R203 T1218 T1216 pobj pathogenesis,in
R204 T1219 T1218 prep of,pathogenesis
R205 T1220 T1221 amod nonsyndromic,defects
R210 T1225 T1211 punct ", ",is
R211 T1226 T1211 cc and,is
R212 T1227 T1228 poss its,necessity
R213 T1228 T1229 nsubj necessity,validates
R218 T1233 T1234 det the,hypothesis
R219 T1234 T1229 dobj hypothesis,validates
R220 T1235 T1236 mark that,have
R225 T1240 T1238 pobj hernia,with
R229 T1244 T1245 amod primary,abnormalities
R233 T1248 T1229 punct .,validates