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we use a taste-salient brief-access lick test [29,37] to measure taste sensitivities in C57BL/6J (B6), DBA/2J (D2) and BXD/Ty (BXD) recombinant inbred (RI) mice to two bitter stimuli, quinine hydrochloride (QHCl) and denatonium benzoate (DB). Using 17 BXD lines that were genotyped at 762 informative chromosomal markers, we mapped a major QTL for QHCl taste to a ~5 Mb interval on distal chromosome 6 that contains all 24 of the Tas2r genes in the distal cluster. We analyzed the sequence of each Tas2r allele in the parental strains (B6 and D2) and 29 RI lines. This analysis revealed that all 24 genes are polymorphic between the two strains, and that these 24 Tas2rs comprise a single haplotype that correlates with QHCl taste sensitivity."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T702","span":{"begin":14,"end":19},"obj":"GO:0050909"},{"id":"T703","span":{"begin":70,"end":75},"obj":"GO:0050909"},{"id":"T704","span":{"begin":137,"end":148},"obj":"GO_SO_EXT:sequence_rearrangement_process"},{"id":"T705","span":{"begin":161,"end":165},"obj":"NCBITaxon:10088"},{"id":"T706","span":{"begin":189,"end":196},"obj":"CHEBI:15854"},{"id":"T707","span":{"begin":197,"end":210},"obj":"CHEBI:17883"},{"id":"T708","span":{"begin":233,"end":241},"obj":"CHEBI:16150"},{"id":"T709","span":{"begin":306,"end":317},"obj":"GO_SO_EXT:chromosome"},{"id":"T710","span":{"begin":318,"end":325},"obj":"CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag"},{"id":"T711","span":{"begin":345,"end":348},"obj":"SO_EXT:0000771"},{"id":"T712","span":{"begin":358,"end":363},"obj":"GO:0050909"},{"id":"T713","span":{"begin":373,"end":374},"obj":"CHEBI_SO_EXT:base"},{"id":"T714","span":{"begin":375,"end":386},"obj":"_FRAGMENT"},{"id":"T715","span":{"begin":394,"end":404},"obj":"GO_SO_EXT:chromosomal_part_or_position_or_region_or_site"},{"id":"T716","span":{"begin":435,"end":440},"obj":"PR_EXT:000036337"},{"id":"T717","span":{"begin":441,"end":446},"obj":"SO_EXT:0000704"},{"id":"T718","span":{"begin":486,"end":494},"obj":"SO_EXT:biological_sequence"},{"id":"T719","span":{"begin":503,"end":508},"obj":"PR_EXT:000036337"},{"id":"T720","span":{"begin":509,"end":515},"obj":"SO_EXT:0001023"},{"id":"T721","span":{"begin":604,"end":609},"obj":"SO_EXT:0000704"},{"id":"T722","span":{"begin":614,"end":625},"obj":"SO_EXT:polymorphism"},{"id":"T723","span":{"begin":669,"end":675},"obj":"PR_EXT:000036337"},{"id":"T724","span":{"begin":694,"end":703},"obj":"SO_EXT:0001024"},{"id":"T725","span":{"begin":730,"end":735},"obj":"GO:0050909"}],"relations":[{"id":"R358","pred":"_lexicallyChainedTo","subj":"T715","obj":"T714"}],"text":"Here we use a taste-salient brief-access lick test [29,37] to measure taste sensitivities in C57BL/6J (B6), DBA/2J (D2) and BXD/Ty (BXD) recombinant inbred (RI) mice to two bitter stimuli, quinine hydrochloride (QHCl) and denatonium benzoate (DB). Using 17 BXD lines that were genotyped at 762 informative chromosomal markers, we mapped a major QTL for QHCl taste to a ~5 Mb interval on distal chromosome 6 that contains all 24 of the Tas2r genes in the distal cluster. We analyzed the sequence of each Tas2r allele in the parental strains (B6 and D2) and 29 RI lines. This analysis revealed that all 24 genes are polymorphic between the two strains, and that these 24 Tas2rs comprise a single haplotype that correlates with QHCl taste sensitivity."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T578","span":{"begin":14,"end":19},"obj":"GO:0050909"},{"id":"T579","span":{"begin":70,"end":75},"obj":"GO:0050909"},{"id":"T580","span":{"begin":161,"end":165},"obj":"NCBITaxon:10088"},{"id":"T581","span":{"begin":189,"end":196},"obj":"CHEBI:15854"},{"id":"T582","span":{"begin":197,"end":210},"obj":"CHEBI:17883"},{"id":"T583","span":{"begin":233,"end":241},"obj":"CHEBI:16150"},{"id":"T584","span":{"begin":345,"end":348},"obj":"SO:0000771"},{"id":"T585","span":{"begin":358,"end":363},"obj":"GO:0050909"},{"id":"T586","span":{"begin":435,"end":440},"obj":"PR:000036337"},{"id":"T587","span":{"begin":441,"end":446},"obj":"SO:0000704"},{"id":"T588","span":{"begin":503,"end":508},"obj":"PR:000036337"},{"id":"T589","span":{"begin":509,"end":515},"obj":"SO:0001023"},{"id":"T590","span":{"begin":604,"end":609},"obj":"SO:0000704"},{"id":"T591","span":{"begin":669,"end":675},"obj":"PR:000036337"},{"id":"T592","span":{"begin":694,"end":703},"obj":"SO:0001024"},{"id":"T593","span":{"begin":730,"end":735},"obj":"GO:0050909"}],"text":"Here we use a taste-salient brief-access lick test [29,37] to measure taste sensitivities in C57BL/6J (B6), DBA/2J (D2) and BXD/Ty (BXD) recombinant inbred (RI) mice to two bitter stimuli, quinine hydrochloride (QHCl) and denatonium benzoate (DB). Using 17 BXD lines that were genotyped at 762 informative chromosomal markers, we mapped a major QTL for QHCl taste to a ~5 Mb interval on distal chromosome 6 that contains all 24 of the Tas2r genes in the distal cluster. We analyzed the sequence of each Tas2r allele in the parental strains (B6 and D2) and 29 RI lines. This analysis revealed that all 24 genes are polymorphic between the two strains, and that these 24 Tas2rs comprise a single haplotype that correlates with QHCl taste sensitivity."}