PMC:1181811 / 31078-33267 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1181811","sourcedb":"PMC","sourceid":"1181811","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1181811","text":"Authors' Contributions\nTN conducted the in silico analysis of the quinine taste QTL, analyzed the Tas2r genes, participated in the design of the study and drafted the manuscript. JB conducted the behavioral studies and QTL analysis. SM assisted with the in silico analysis of the quinine taste QTL and the Tas2rs, and with the QTL analysis. JB and SM conceived of the study, participated in its design, and edited the manuscript. All authors read and approved the final manuscript. Comments and requests should be addressed to JB or SM.\nTable 2 Linkage of a QHCl QTL to D6Mit13 on chromosome 6.\n1 mM qhcl 3 mM qhcl\nChr Marker Position (Mb) LRS % Var p Add LRS % Var p Add\n6 D6Mit150 116.543 12.1 51 0.0005 0.16 11.9 50 0.00057 0.08\n6 D6Mit254 125.974 11.4 49 0.00075 0.16 11.1 48 0.00087 0.07\n6 D6Mit194 126.895 11.4 49 0.00075 0.16 11.1 48 0.00087 0.07\n6 D6Mit61 129.173 nd nd nd nd nd nd nd nd\n6 D6Mit13 132.672 21.0 71 0.000001* 0.19 17.9 65 0.00002 0.09\n6 D6Mit374 134.172 14.0 56 0.00018 0.17 14.3 57 0.00015 0.08\n6 D6Mit301 136.104 14.0 56 0.00018 0.17 14.3 57 0.00015 0.08\n6 SO6Gnf140.060 140.060 11.9 50 0.00056 0.17 12.7 53 0.00037 0.08\n8 SO8Gnf046.785 46.785 13.4 55 0.00025 0.17 12.2 51 0.00047 0.08\nMarkers are listed from proximal (D6Mit150) to distal (SO8Gnf046.785), with physical position indicated in Mb. The physical position of D6Mit194 (italics) should be considered tentative. The LRS (likelihood ratio statistic) is listed for each locus, signifying the level of association of the trait (QHCl taste sensitivity) with each locus. Variance (Var) refers to the amount of the total trait variance explained by a QTL at this locus, as a percentage. Additive regression coefficients (Add) are listed for each association; in each case the coefficient is positive, indicating that D2 alleles increase the trait value (i.e. higher lick ratios). In simple marker regression analysis, all of these loci are associated with QHCl sensitivity at p \u003c 0.001; only the association of sensitivity to 1 mM QHCl with D6Mit13 reaches genome-wide significance 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