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Id Subject Object Predicate Lexical cue
T7341 19046-19047 . denotes .
T7340 19042-19046 NN denotes QHCL
T7339 19039-19041 NN denotes mM
T7338 19037-19038 CD denotes 1
T7337 19034-19036 IN denotes to
T7336 19024-19033 JJ denotes sensitive
T7335 19019-19023 RBS denotes most
T7334 19016-19018 IN denotes to
T7333 19010-19015 RBS denotes least
T7332 19005-19009 IN denotes from
T7331 18999-19004 NN denotes order
T7330 18996-18998 IN denotes in
T7329 18985-18988 VBP denotes are
T7328 18989-18995 VBN denotes listed
T7327 18973-18976 NN denotes BXD
T7326 18977-18984 NNS denotes strains
T7325 18969-18972 DT denotes The
T7324 18968-19047 sentence denotes The BXD strains are listed in order from least to most sensitive to 1 mM QHCL.
T7323 18967-18968 . denotes .
T7322 18966-18967 -RRB- denotes )
T7321 18955-18960 JJ denotes right
T7320 18953-18955 , denotes ,
T7319 18948-18953 NNS denotes lines
T7318 18944-18947 JJ denotes red
T7317 18961-18966 NN denotes panel
T7316 18943-18944 -LRB- denotes (
T7315 18927-18932 NN denotes Tas2r
T7314 18924-18926 NN denotes D2
T7313 18933-18942 NN denotes haplotype
T7312 18920-18923 DT denotes the
T7311 18915-18919 IN denotes with
T7310 18907-18914 NNS denotes strains
T7309 18903-18906 NN denotes BXD
T7308 18899-18902 VBP denotes are
T7307 18894-18898 IN denotes than
T7306 18889-18893 NN denotes QHCl
T7305 18886-18888 IN denotes to
T7304 18876-18885 JJ denotes sensitive
T7303 18871-18875 RBR denotes more
T7302 18865-18866 -RRB- denotes )
T7301 18854-18859 JJ denotes right
T7300 18852-18854 , denotes ,
T7299 18847-18852 NNS denotes lines
T7298 18842-18846 JJ denotes blue
T7297 18860-18865 NN denotes panel
T7296 18841-18842 -LRB- denotes (
T7295 18825-18830 NN denotes Tas2r
T7294 18822-18824 NN denotes B6
T7293 18831-18840 NN denotes haplotype
T7292 18818-18821 DT denotes the
T7291 18813-18817 IN denotes with
T7290 18805-18812 NNS denotes strains
T7289 18801-18804 NN denotes BXD
T7288 18799-18801 , denotes ,
T7287 18867-18870 VBP denotes are
T7286 18790-18799 RB denotes Similarly
T7285 18789-18968 sentence denotes Similarly, BXD strains with the B6 Tas2r haplotype (blue lines, right panel) are more sensitive to QHCl than are BXD strains with the D2 Tas2r haplotype (red lines, right panel).
T7284 18788-18789 . denotes .
T7283 18777-18782 NN denotes taste
T7282 18783-18788 NNS denotes tests
T7281 18770-18776 NN denotes access
T7280 18764-18769 JJ denotes brief
T7279 18761-18763 IN denotes in
T7278 18759-18760 -RRB- denotes )
T7277 18754-18759 NN denotes panel
T7276 18749-18753 JJ denotes left
T7275 18746-18748 IN denotes on
T7274 18737-18740 JJ denotes red
T7273 18741-18745 NN denotes line
T7272 18736-18737 -LRB- denotes (
T7271 18731-18735 NNS denotes mice
T7270 18728-18730 NN denotes D2
T7262 18700-18701 CD denotes 1
T7261 18697-18699 IN denotes to
T7260 18687-18696 JJ denotes sensitive
T7259 18682-18686 RBR denotes more
T7258 18676-18677 -RRB- denotes )
T7257 18671-18676 NN denotes panel
T7256 18666-18670 JJ denotes left
T7255 18663-18665 IN denotes on
T7254 18653-18657 JJ denotes blue
T7253 18658-18662 NN denotes line
T7252 18652-18653 -LRB- denotes (
T7251 18678-18681 VBP denotes are
T7250 18647-18651 NNS denotes mice
T7249 18644-18646 NN denotes B6
T7248 18643-18789 sentence denotes B6 mice (blue line on left panel) are more sensitive to 1 mM and 3 mM QHCl than are D2 mice (red line on left panel) in brief access taste tests.
T7247 18642-18643 . denotes .
T7246 18641-18642 -RRB- denotes )
T7245 18636-18637 SYM denotes =
T7244 18626-18635 NN denotes haplotype
T7243 18623-18625 NN denotes D2
T7242 18621-18623 , denotes ,
T7241 18615-18616 SYM denotes =
T7240 18617-18621 JJ denotes blue
T7239 18605-18614 NN denotes haplotype
T7238 18602-18604 NN denotes B6
T7237 18638-18641 JJ denotes red
T7236 18601-18602 -LRB- denotes (
T7235 18591-18600 NN denotes haplotype
T7234 18585-18590 NN denotes Tas2r
T7233 18582-18584 IN denotes on
T7232 18576-18581 VBN denotes based
T7231 18564-18567 VBP denotes are
T7230 18562-18563 CD denotes 1
T7229 18555-18561 NN denotes Figure
T7228 18552-18554 IN denotes in
T7227 18543-18551 VBN denotes reported
T7226 18531-18534 NN denotes BXD
T7225 18527-18530 CC denotes and
T7224 18524-18526 NN denotes D2
T7223 18522-18524 , denotes ,
T7222 18535-18542 NNS denotes strains
T7221 18520-18522 NN denotes B6
T7220 18517-18519 IN denotes of
T7219 18568-18575 VBN denotes grouped
T7218 18505-18509 NN denotes lick
T7217 18510-18516 NNS denotes ratios
T7216 18500-18504 NN denotes Mean
T7215 18499-18643 sentence denotes Mean lick ratios of B6, D2 and BXD strains reported in Figure 1 are grouped based on Tas2r haplotype (B6 haplotype = blue, D2 haplotype = red).
T7214 18498-18499 . denotes .
T7213 18489-18498 NN denotes phenotype
T7212 18483-18488 NN denotes taste
T7211 18478-18482 NN denotes QHCl
T7210 18473-18477 IN denotes with
T7209 18462-18472 VBZ denotes correlates
T7208 18453-18461 NN denotes genotype
T7207 18447-18452 NN denotes Tas2r
T7179 18435-18436 . denotes .
T7178 18434-18435 -RRB- denotes )
T7177 18433-18434 SYM denotes *
T7176 18432-18433 -LRB- denotes (
T7175 18418-18421 VBP denotes are
T7174 18412-18417 NN denotes study
T7173 18407-18411 DT denotes this
T7172 18404-18406 IN denotes in
T7171 18384-18396 RB denotes behaviorally
T7170 18379-18383 VBD denotes were
T7169 18397-18403 VBN denotes tested
T7168 18374-18378 WDT denotes that
T7167 18422-18431 VBN denotes indicated
T7166 18362-18365 NN denotes BXD
T7165 18359-18361 CD denotes 17
T7164 18366-18373 NNS denotes strains
T7163 18355-18358 DT denotes The
T7162 18354-18436 sentence denotes The 17 BXD strains that were behaviorally tested in this study are indicated (*).
T7161 18353-18354 . denotes .
T7160 18352-18353 -RRB- denotes )
T7159 18345-18346 SYM denotes =
T7158 18338-18344 NN denotes allele
T7157 18335-18337 NN denotes D2
T7156 18333-18335 , denotes ,
T7155 18327-18328 SYM denotes =
T7154 18329-18333 NN denotes gray
T7153 18320-18326 NN denotes allele
T7152 18317-18319 NN denotes B6
T7151 18347-18352 JJ denotes white
T7150 18316-18317 -LRB- denotes (
T7149 18300-18308 JJ denotes parental
T7148 18295-18299 JJ denotes same
T7147 18309-18315 NN denotes strain
T7146 18291-18294 DT denotes the
T7145 18286-18290 IN denotes from
T7144 18264-18267 NN denotes BXD
T7143 18253-18263 JJ denotes individual
T7142 18268-18274 NN denotes strain
T7141 18250-18252 DT denotes an
T7140 18243-18249 IN denotes within
T7139 18275-18285 VBD denotes originated
T7138 18237-18242 NN denotes Tas2r
T7137 18232-18236 DT denotes Each
T7136 18231-18354 sentence denotes Each Tas2r within an individual BXD strain originated from the same parental strain (B6 allele = gray, D2 allele = white).
T7135 18230-18231 . denotes .
T7134 18220-18222 JJ denotes RI
T7133 18216-18217 HYPH denotes /
T7132 18217-18219 NN denotes Ty
T7131 18213-18216 NN denotes BXD
T7130 18223-18230 NNS denotes strains
T7129 18210-18212 CD denotes 29
T7128 18205-18209 IN denotes from
T7127 18193-18200 JJ denotes genomic
T7126 18201-18204 NN denotes DNA
T7125 18183-18192 VBN denotes amplified
T7124 18169-18170 CD denotes 6
T7123 18158-18168 NN denotes chromosome
T7122 18151-18157 JJ denotes distal
T7121 18171-18178 NN denotes cluster
T7120 18147-18150 DT denotes the
T7119 18144-18146 IN denotes in
T7118 18137-18143 NNS denotes Tas2rs
T7117 18134-18136 CD denotes 21
T7116 18131-18133 IN denotes of
T7115 18126-18130 DT denotes each
T7114 18123-18125 IN denotes of
T7113 18179-18182 VBD denotes was
T7112 18111-18117 VBG denotes coding
T7111 18118-18122 NN denotes exon
T7110 18107-18110 DT denotes The
T7109 18106-18231 sentence denotes The coding exon of each of 21 Tas2rs in the distal chromosome 6 cluster was amplified genomic DNA from 29 BXD/Ty RI strains.
T7108 18105-18106 . denotes .
T7107 18098-18100 JJ denotes RI
T7106 18101-18105 NNS denotes mice
T7105 18094-18095 HYPH denotes /
T7104 18095-18097 NN denotes Ty
T7103 18091-18094 NN denotes BXD
T7102 18088-18090 IN denotes in
T7101 18071-18077 JJ denotes single
T7100 18078-18087 NN denotes haplotype
T7099 18069-18070 DT denotes a
T7098 18066-18068 VBZ denotes is
T7097 18052-18057 NN denotes Tas2r
T7096 18058-18065 NN denotes cluster
T7095 18048-18051 DT denotes The
T7073 16667-16668 . denotes .
T7072 16651-16667 NNS denotes oligonucleotides
T7071 16647-16650 CC denotes and
T7070 16639-16646 NNS denotes enzymes
T7069 16627-16638 NN denotes restriction
T7068 16623-16626 IN denotes for
T7067 16621-16622 CD denotes 3
T7066 16615-16620 NN denotes Table
T7065 16613-16615 : denotes :
T7064 16612-16613 CD denotes 1
T7063 16607-16611 NN denotes file
T7062 16596-16606 JJ denotes additional
T7061 16592-16595 VB denotes See
T7060 16591-16668 sentence denotes See additional file 1: Table 3 for restriction enzymes and oligonucleotides.
T7059 16590-16591 . denotes .
T7058 16589-16590 -RRB- denotes )
T7057 16573-16579 NN denotes taster
T7056 16570-16572 NN denotes D2
T7055 16568-16569 SYM denotes =
T7054 16564-16567 NN denotes red
T7053 16562-16564 , denotes ,
T7052 16546-16552 NN denotes taster
T7051 16543-16545 NN denotes B6
T7050 16541-16542 SYM denotes =
T7049 16553-16562 NN denotes phenotype
T7048 16536-16540 NN denotes blue
T7047 16580-16589 NN denotes phenotype
T6949 13860-13861 . denotes .
T6948 13851-13853 NN denotes B6
T6947 13854-13860 NN denotes genome
T6946 13847-13850 DT denotes the
T6945 13844-13846 IN denotes of
T6944 13830-13834 CD denotes 2004
T6943 13828-13830 , denotes ,
T6942 13825-13828 NN denotes May
T6941 13835-13843 NN denotes assembly
T6940 13821-13824 DT denotes the
T6939 13818-13820 IN denotes in
T6938 13806-13807 CD denotes 6
T6937 13808-13817 NNS denotes positions
T6936 13795-13805 NN denotes chromosome
T6935 13783-13785 , denotes ,
T6934 13781-13783 NN denotes Mb
T6933 13778-13780 IN denotes in
T6932 13776-13778 , denotes ,
T6931 13785-13794 VBP denotes represent
T6930 13767-13776 NNS denotes positions
T6929 13763-13766 NN denotes Map
T6928 13762-13861 sentence denotes Map positions, in Mb, represent chromosome 6 positions in the May, 2004 assembly of the B6 genome.
T6927 13761-13762 . denotes .
T6926 13760-13761 -RRB- denotes )
T6925 13757-13760 JJ denotes red
T6924 13755-13756 : denotes ;
T6923 13751-13755 NN denotes Prh1
T6922 13747-13750 CC denotes and
T6921 13742-13746 NN denotes Prp2
T6920 13741-13742 -LRB- denotes (
T6919 13723-13731 JJ denotes salivary
T6918 13732-13740 NN denotes proteins
T6917 13717-13718 HYPH denotes -
T6916 13718-13722 JJ denotes rich
T6915 13710-13717 NN denotes proline
T6914 13701-13709 VBG denotes encoding
T6913 13695-13700 NNS denotes genes
T6912 13691-13694 CD denotes two
T6911 13687-13690 CC denotes and
T6910 13685-13686 -RRB- denotes )
T6909 13682-13685 JJ denotes red
T6908 13681-13682 -LRB- denotes (
T6907 13666-13672 NN denotes marker
T6906 13654-13665 JJ denotes polymorphic
T6905 13673-13680 NN denotes D6Mit13
T6904 13650-13653 DT denotes the
T6903 13647-13649 IN denotes of
T6902 13642-13646 NN denotes side
T6901 13635-13641 DT denotes either
T6900 13632-13634 IN denotes on
T6899 13620-13631 NNS denotes subclusters
T6898 13616-13619 CD denotes two
T6897 13613-13615 IN denotes in
T6896 13603-13606 VBP denotes are
T6895 13607-13612 VBN denotes found
T6894 13596-13602 NNS denotes Tas2rs
T6893 13592-13595 DT denotes The
T6892 13591-13762 sentence denotes The Tas2rs are found in two subclusters on either side of the polymorphic marker D6Mit13 (red) and two genes encoding proline-rich salivary proteins (Prp2 and Prh1; red).
T6891 13590-13591 . denotes .
T6890 13589-13590 -RRB- denotes )
T6889 13584-13589 JJ denotes black
T6888 13583-13584 -LRB- denotes (
T6887 13581-13582 CD denotes 6
T6886 13570-13580 NN denotes chromosome
T6885 13563-13569 JJ denotes distal
T6884 13560-13562 IN denotes to
T6883 13556-13559 VBP denotes map
T6882 13544-13549 NN denotes Tas2r
T6881 13537-13543 JJ denotes intact
T6880 13550-13555 NNS denotes genes
T6879 13531-13532 HYPH denotes -
T6878 13532-13536 CD denotes four
T6877 13525-13531 CD denotes Twenty
T6876 13524-13591 sentence denotes Twenty-four intact Tas2r genes map to distal chromosome 6 (black).
T6875 13523-13524 . denotes .
T6874 13510-13515 NN denotes Tas2r
T6873 13508-13509 CD denotes 6
T6872 13497-13507 NN denotes chromosome
T6871 13490-13496 JJ denotes distal
T6870 13516-13523 NN denotes cluster
T6869 13486-13489 DT denotes the
T6868 13483-13485 IN denotes of
T6867 13479-13482 NN denotes map
T6866 13477-13478 DT denotes A
T6836 13465-13466 . denotes .
T6835 13456-13465 JJ denotes tentative
T6834 13451-13452 -RRB- denotes )
T6833 13450-13451 SYM denotes *
T6832 13449-13450 -LRB- denotes (
T6831 13440-13448 NN denotes D6Mit194
T6830 13437-13439 IN denotes of
T6829 13453-13455 VBZ denotes is
T6828 13419-13427 JJ denotes physical
T6827 13428-13436 NN denotes position
T6826 13415-13418 DT denotes The
T6825 13414-13466 sentence denotes The physical position of D6Mit194 (*) is tentative.
T6824 13413-13414 . denotes .
T6823 13401-13406 NN denotes mouse
T6822 13398-13400 NN denotes B6
T6821 13407-13413 NN denotes genome
T6820 13394-13397 DT denotes the
T7269 18724-18727 VBP denotes are
T7268 18719-18723 IN denotes than
T7267 18711-18713 NN denotes mM
T7266 18709-18710 CD denotes 3
T7265 18705-18708 CC denotes and
T7264 18714-18718 NN denotes QHCl
T7263 18702-18704 NN denotes mM
T6819 13391-13393 IN denotes of
T6818 13380-13384 CD denotes 2004
T6817 13378-13380 , denotes ,
T6816 13375-13378 NNP denotes May
T6815 13385-13390 NN denotes build
T6814 13371-13374 DT denotes the
T6813 13368-13370 IN denotes on
T6812 13362-13367 VBN denotes based
T6811 13358-13361 VBP denotes are
T6810 13354-13357 CC denotes and
T6809 13352-13354 , denotes ,
T6808 13350-13352 NN denotes Mb
T6807 13347-13349 IN denotes in
T6806 13337-13340 VBP denotes are
T6805 13317-13328 JJ denotes polymorphic
T6804 13329-13336 NNS denotes markers
T6803 13313-13316 DT denotes the
T6802 13310-13312 IN denotes of
T6801 13341-13346 VBN denotes given
T6800 13300-13309 NNS denotes positions
T6799 13291-13299 JJ denotes Physical
T6798 13290-13414 sentence denotes Physical positions of the polymorphic markers are given in Mb, and are based on the May, 2004 build of the B6 mouse genome.
T6797 13289-13290 . denotes .
T6796 13288-13289 -RRB- denotes )
T6795 13280-13284 JJ denotes gray
T6794 13285-13288 NN denotes box
T6793 13279-13280 -LRB- denotes (
T6792 13272-13278 NNS denotes Tas2rs
T6791 13268-13271 DT denotes the
T6790 13266-13268 , denotes ,
T6789 13252-13260 NN denotes receptor
T6788 13246-13251 NN denotes taste
T6787 13239-13245 JJ denotes bitter
T6786 13261-13266 NNS denotes genes
T6785 13230-13238 JJ denotes putative
T6784 13227-13229 IN denotes of
T6783 13219-13226 NN denotes cluster
T6782 13217-13218 DT denotes a
T6781 13206-13207 -RRB- denotes )
T6780 13203-13206 CD denotes 374
T6779 13197-13202 NN denotes D6Mit
T6778 13193-13196 CC denotes and
T6777 13185-13192 NN denotes D6Mit61
T6776 13177-13184 NNS denotes markers
T6775 13168-13176 JJ denotes unlinked
T6774 13160-13167 IN denotes between
T6773 13155-13159 VBZ denotes lies
T6772 13149-13154 WDT denotes which
T6771 13148-13149 -LRB- denotes (
T6770 13139-13143 NN denotes QHCl
T6769 13144-13147 NN denotes QTL
T6768 13135-13138 DT denotes The
T6767 13133-13134 -RRB- denotes )
T6766 13208-13216 VBZ denotes contains
T6765 13132-13133 LS denotes B
T6764 13131-13132 -LRB- denotes (
T6763 13130-13290 sentence denotes (B) The QHCl QTL (which lies between unlinked markers D6Mit61 and D6Mit 374) contains a cluster of putative bitter taste receptor genes, the Tas2rs (gray box).
T6762 13129-13130 . denotes .
T6761 13117-13129 NN denotes significance
T6760 13111-13112 HYPH denotes -
T6759 13112-13116 JJ denotes wide
T6758 13105-13111 NN denotes genome
T6757 13095-13104 VBZ denotes indicates
T6756 13083-13089 JJ denotes dashed
T6755 13090-13094 NN denotes line
T6754 13079-13082 DT denotes The
T6753 13078-13130 sentence denotes The dashed line indicates genome-wide significance.
T6752 13077-13078 . denotes .
T6751 13076-13077 -RRB- denotes )
T6750 13072-13076 NN denotes bold
T6749 13071-13072 -LRB- denotes (
T6748 13063-13070 NN denotes D6Mit13
T6747 13044-13055 JJ denotes polymorphic
T6746 13056-13062 NN denotes marker
T6745 13040-13043 DT denotes the
T6744 13035-13039 IN denotes with
T6743 13024-13026 JJ denotes RI
T6742 13027-13034 NNS denotes strains
T6741 13020-13023 NN denotes BXD
T6740 13013-13019 IN denotes across
T6722 12928-12931 NN denotes map
T6721 12915-12918 DT denotes the
T6720 12912-12914 IN denotes in
T6719 12906-12911 VBN denotes shown
T6718 12903-12905 IN denotes As
T6717 12901-12902 -RRB- denotes )
T6716 12993-13003 VBZ denotes correlates
T6715 12900-12901 LS denotes A
T6714 12899-12900 -LRB- denotes (
T6713 12898-13078 sentence denotes (A) As shown in the interval map for chromosome 6, the trait value (lick ratio for 1 mM QHCl) correlates strongly across BXD RI strains with the polymorphic marker D6Mit13 (bold).
T6712 12897-12898 . denotes .
T6711 12896-12897 CD denotes 6
T6710 12885-12895 NN denotes chromosome
T6709 12882-12884 IN denotes on
T6708 12868-12874 JJ denotes single
T6707 12875-12881 NN denotes marker
T6706 12866-12867 DT denotes a
T6705 12863-12865 IN denotes to
T6704 12853-12855 VBZ denotes is
T6703 12856-12862 VBN denotes linked
T6702 12844-12848 NN denotes QHCl
T6701 12849-12852 NN denotes QTL
T6700 12840-12843 DT denotes The
T6675 10953-10954 . denotes .
T6674 10941-10953 NN denotes significance
T6673 10935-10936 HYPH denotes -
T6672 10936-10940 JJ denotes wide
T6671 10929-10935 NN denotes genome
T6670 10919-10928 VBZ denotes indicates
T6669 10907-10913 JJ denotes dashed
T6668 10914-10918 NN denotes line
T6667 10903-10906 DT denotes The
T6666 10902-10954 sentence denotes The dashed line indicates genome-wide significance.
T6665 10901-10902 . denotes .
T6664 10900-10901 -RRB- denotes )
T6663 10894-10900 JJ denotes yellow
T6662 10893-10894 -LRB- denotes (
T6661 10882-10892 JJ denotes suggestive
T6660 10873-10876 NN denotes QTL
T6659 10868-10872 DT denotes both
T6658 10866-10868 , denotes ,
T6657 10862-10866 NN denotes QHCl
T6656 10859-10861 NN denotes mM
T6655 10857-10858 CD denotes 3
T6654 10853-10856 IN denotes For
T6653 10851-10852 -RRB- denotes )
T6652 10877-10881 VBD denotes were
T6651 10839-10845 JJ denotes Bottom
T6650 10846-10851 NN denotes panel
T6649 10838-10839 -LRB- denotes (
T6648 10837-10902 sentence denotes (Bottom panel) For 3 mM QHCl, both QTL were suggestive (yellow).
T6647 10836-10837 . denotes .
T6646 10832-10836 NN denotes QHCl
T6645 10829-10831 NN denotes mM
T6644 10827-10828 CD denotes 1
T6643 10824-10826 IN denotes to
T6642 10814-10823 NNS denotes responses
T6641 10808-10813 NN denotes taste
T6640 10798-10807 VBG denotes affecting
T6639 10796-10797 -RRB- denotes )
T6638 10790-10796 JJ denotes yellow
T6637 10789-10790 -LRB- denotes (
T6636 10787-10788 CD denotes 8
T6635 10776-10786 NN denotes chromosome
T6634 10773-10775 IN denotes on
T6633 10758-10768 JJ denotes suggestive
T6632 10769-10772 NN denotes QTL
T6631 10756-10757 DT denotes a
T6630 10752-10755 CC denotes and
T6629 10750-10751 -RRB- denotes )
T6628 10745-10750 JJ denotes green
T6627 10744-10745 -LRB- denotes (
T6626 10742-10743 CD denotes 6
T6625 10731-10741 NN denotes chromosome
T6624 10728-10730 IN denotes on
T6623 10712-10723 JJ denotes significant
T6622 10724-10727 NN denotes QTL
T6621 10710-10711 DT denotes a
T6620 10702-10703 -RRB- denotes )
T6619 10695-10702 NNS denotes Methods
T6618 10691-10694 VB denotes see
T6617 10690-10691 -LRB- denotes (
T6616 10677-10685 NN denotes interval
T6615 10686-10689 NN denotes map
T6614 10673-10676 DT denotes The
T6613 10671-10672 -RRB- denotes )
T6612 10704-10709 VBZ denotes shows
T6611 10662-10665 JJ denotes Top
T6610 10666-10671 NN denotes panel
T6609 10661-10662 -LRB- denotes (
T6608 10660-10837 sentence denotes (Top panel) The interval map (see Methods) shows a significant QTL on chromosome 6 (green) and a suggestive QTL on chromosome 8 (yellow) affecting taste responses to 1 mM QHCl.
T6607 10659-10660 . denotes .
T6606 10658-10659 CD denotes 6
T6605 10647-10657 NN denotes chromosome
T6604 10641-10646 NN denotes mouse
T6603 10638-10640 IN denotes on
T6602 10632-10637 NN denotes taste
T6601 10627-10631 NN denotes QHCl
T6600 10623-10626 IN denotes for
T6599 10613-10618 JJ denotes major
T6598 10619-10622 NN denotes QTL
T6597 10611-10612 DT denotes A
T7046 16535-16536 -LRB- denotes (
T7045 16525-16534 NN denotes phenotype
T7044 16518-16524 NN denotes taster
T7043 16513-16517 NN denotes QHCl
T7042 16508-16512 IN denotes with
T7041 16490-16496 RB denotes always
T7040 16486-16489 VBD denotes was
T7039 16477-16485 NN denotes genotype
T7038 16471-16476 NN denotes Tas2r
T7037 16469-16471 , denotes ,
T7036 16463-16469 VBN denotes tested
T7035 16451-16454 NN denotes BXD
T7034 16448-16450 CD denotes 17
T7033 16455-16462 NNS denotes strains
T7032 16444-16447 DT denotes the
T7031 16441-16443 IN denotes of
T7030 16436-16440 DT denotes each
T7029 16497-16507 VBN denotes correlated
T7028 16433-16435 IN denotes In
T7027 16432-16591 sentence denotes In each of the 17 BXD strains tested, Tas2r genotype was always correlated with QHCl taster phenotype (blue = B6 taster phenotype, red = D2 taster phenotype).
T7026 16431-16432 . denotes .
T7025 16430-16431 -RRB- denotes )
T7024 16422-16430 NN denotes Tas2r120
T7023 16421-16422 -LRB- denotes (
T7022 16409-16412 NN denotes PCR
T7021 16413-16420 NN denotes product
T7020 16407-16408 DT denotes a
T7019 16404-16406 IN denotes of
T7018 16396-16403 NN denotes absence
T7017 16393-16395 CC denotes or
T7016 16384-16392 NN denotes presence
T7015 16380-16383 DT denotes the
T7014 16377-16379 IN denotes on
T7013 16374-16376 CC denotes or
T7012 16372-16373 -RRB- denotes )
T7011 16364-16372 NN denotes Tas2r131
T7010 16360-16363 CC denotes and
T7009 16351-16359 NN denotes Tas2r116
T7008 16349-16351 , denotes ,
T7007 16341-16349 NN denotes Tas2r105
T7006 16340-16341 -LRB- denotes (
T7005 16327-16330 NN denotes PCR
T7004 16331-16339 NNS denotes products
T7003 16317-16326 VBN denotes amplified
T7002 16314-16316 IN denotes of
T7001 16294-16305 NN denotes restriction
T7000 16306-16313 NNS denotes digests
T6999 16283-16293 JJ denotes diagnostic
T6998 16280-16282 IN denotes on
T6997 16274-16279 VBN denotes based
T6996 16256-16258 VB denotes be
T6995 16252-16255 MD denotes can
T6994 16245-16251 NNS denotes Tas2rs
T6993 16240-16244 CD denotes four
T6992 16237-16239 IN denotes of
T6991 16259-16273 VBN denotes differentiated
T6990 16226-16228 NN denotes D2
T6989 16222-16225 CC denotes and
T6988 16229-16236 NNS denotes alleles
T6987 16219-16221 NN denotes B6
T6986 16218-16432 sentence denotes B6 and D2 alleles of four Tas2rs can be differentiated based on diagnostic restriction digests of amplified PCR products (Tas2r105, Tas2r116 and Tas2r131) or on the presence or absence of a PCR product (Tas2r120).
T6985 16217-16218 . denotes .
T6984 16211-16217 NNS denotes Tas2rs
T6983 16206-16210 CD denotes four
T6982 16202-16205 IN denotes for
T6981 16194-16201 NNS denotes strains
T6980 16187-16193 IN denotes across
T6979 16177-16186 NN denotes variation
T6978 16169-16176 JJ denotes Allelic
T6576 9630-9631 . denotes .
T6575 9623-9630 NN denotes control
T6574 9613-9622 JJ denotes polygenic
T6573 9607-9612 IN denotes under
T6572 9599-9603 NN denotes QHCL
T6571 9596-9598 IN denotes to
T6570 9584-9595 NN denotes sensitivity
T6569 9604-9606 VBZ denotes is
T6568 9579-9583 IN denotes that
T6567 9551-9561 JJ denotes phenotypic
T6566 9542-9550 JJ denotes distinct
T6565 9562-9569 NNS denotes classes
T6564 9538-9541 CD denotes two
T6563 9535-9537 IN denotes of
T6562 9570-9578 VBZ denotes suggests
T6561 9527-9534 NN denotes absence
T6560 9523-9526 DT denotes The
T6559 9522-9631 sentence denotes The absence of two distinct phenotypic classes suggests that sensitivity to QHCL is under polygenic control.
T6558 9521-9522 . denotes .
T6557 9516-9517 SYM denotes >
T6556 9518-9521 CD denotes 0.6
T6555 9508-9515 NNS denotes strains
T6554 9496-9507 JJ denotes insensitive
T6553 9492-9495 CC denotes and
T6552 9490-9492 , denotes ,
T6551 9486-9487 SYM denotes -
T6550 9482-9486 CD denotes 0.31
T6549 9477-9481 IN denotes from
T6548 9487-9490 CD denotes 0.6
T6547 9469-9476 NNS denotes strains
T6546 9456-9468 JJ denotes intermediate
T6545 9454-9456 , denotes ,
T6544 9451-9454 CD denotes 0.3
T6543 9449-9450 SYM denotes ≤
T6542 9446-9448 IN denotes of
T6541 9441-9445 NN denotes QHCl
T6540 9438-9440 NN denotes mM
T6539 9436-9437 CD denotes 1
T6538 9432-9435 IN denotes for
T6537 9421-9425 NN denotes lick
T6536 9426-9431 NN denotes ratio
T6535 9419-9420 DT denotes a
T6534 9401-9408 NNS denotes strains
T6533 9391-9400 JJ denotes sensitive
T6532 9389-9391 : denotes :
T6531 9385-9389 NN denotes QHCl
T6530 9382-9384 NN denotes mM
T6529 9380-9381 CD denotes 1
T6528 9377-9379 IN denotes at
T6527 9367-9376 NN denotes phenotype
T6526 9363-9366 DT denotes the
T6525 9360-9362 IN denotes of
T6524 9349-9359 NN denotes continuity
T6523 9347-9348 DT denotes a
T6522 9337-9342 EX denotes there
T6521 9343-9346 VBD denotes was
T6520 9334-9336 IN denotes as
T6519 9332-9334 , denotes ,
T6518 9409-9418 VBD denotes exhibited
T6517 9317-9328 RB denotes arbitrarily
T6516 9312-9316 VBD denotes were
T6515 9298-9304 NN denotes taster
T6514 9293-9297 NN denotes QHCl
T6513 9287-9292 CD denotes three
T6512 9305-9311 NNS denotes groups
T6511 9283-9286 DT denotes the
T6510 9279-9282 IN denotes for
T6509 9329-9332 VBN denotes set
T6508 9271-9278 NNS denotes Cutoffs
T6507 9270-9522 sentence denotes Cutoffs for the three QHCl taster groups were arbitrarily set, as there was a continuity of the phenotype at 1 mM QHCl: sensitive strains exhibited a lick ratio for 1 mM QHCl of ≤ 0.3, intermediate strains from 0.31-0.6, and insensitive strains > 0.6.
T6403 8830-8836 NNS denotes panels
T6402 8869-8880 VBN denotes represented
T6401 8826-8829 IN denotes For
T6400 8825-8975 sentence denotes For panels B, C, and D, each BXD strain is represented by a different color, and listed in order from least sensitive to most sensitive to 1 mM QHCL.
T6399 8824-8825 . denotes .
T6398 8816-8824 NN denotes stimulus
T6397 8812-8815 DT denotes the
T6396 8809-8811 IN denotes to
T6395 8807-8809 , denotes ,
T6394 8790-8795 NN denotes taste
T6393 8782-8789 JJR denotes greater
T6392 8796-8807 NN denotes sensitivity
T6391 8772-8781 RB denotes therefore
T6390 8768-8771 CC denotes and
T6389 8766-8768 , denotes ,
T6388 8750-8757 JJR denotes greater
T6387 8758-8766 NN denotes aversion
T6386 8748-8749 DT denotes a
T6385 8727-8731 NN denotes lick
T6384 8722-8726 NN denotes mean
T6383 8716-8721 JJR denotes lower
T6382 8732-8737 NN denotes ratio
T6381 8714-8715 DT denotes a
T6380 8712-8714 , denotes ,
T6379 8706-8712 NNS denotes panels
T6378 8702-8705 DT denotes all
T6377 8738-8747 VBZ denotes indicates
T6376 8699-8701 IN denotes In
T6375 8698-8825 sentence denotes In all panels, a lower mean lick ratio indicates a greater aversion, and therefore greater taste sensitivity, to the stimulus.
T6374 8697-8698 . denotes .
T6373 8695-8697 NN denotes DB
T6372 8691-8694 CC denotes and
T6371 8686-8690 NN denotes QHCl
T6370 8683-8685 IN denotes of
T6369 8668-8682 NNS denotes concentrations
T6368 8664-8667 CD denotes two
T6367 8661-8663 IN denotes at
T6366 8654-8655 -RRB- denotes )
T6365 8642-8646 JJ denotes open
T6364 8647-8654 NNS denotes circles
T6363 8641-8642 -LRB- denotes (
T6362 8638-8640 NN denotes D2
T6361 8634-8637 CC denotes and
T6360 8632-8633 -RRB- denotes )
T6359 8618-8624 VBN denotes filled
T6358 8625-8632 NNS denotes circles
T6357 8617-8618 -LRB- denotes (
T6356 8656-8660 NNS denotes mice
T6355 8614-8616 NN denotes B6
T6354 8610-8613 IN denotes for
T6353 8598-8602 NN denotes lick
T6352 8593-8597 NN denotes Mean
T6351 8591-8592 -RRB- denotes )
T6350 8603-8609 NNS denotes ratios
T6349 8590-8591 LS denotes A
T6348 8589-8590 -LRB- denotes (
T6347 8588-8698 sentence denotes (A) Mean lick ratios for B6 (filled circles) and D2 (open circles) mice at two concentrations of QHCl and DB.
T6346 8587-8588 . denotes .
T6345 8576-8579 NN denotes BXD
T6344 8572-8575 CC denotes and
T6343 8569-8571 NN denotes D2
T6342 8567-8569 , denotes ,
T6341 8580-8587 NNS denotes strains
T6340 8565-8567 NN denotes B6
T6339 8561-8564 IN denotes for
T6338 8559-8560 -RRB- denotes )
T6337 8555-8556 SYM denotes ±
T6336 8550-8554 NN denotes mean
T6335 8557-8559 NN denotes SE
T6334 8549-8550 -LRB- denotes (
T6333 8542-8548 NNS denotes ratios
T6332 8537-8541 NN denotes Lick
T6320 31075-31076 . denotes .
T6319 31066-31068 NN denotes D2
T6318 31069-31075 NN denotes allele
T6317 31062-31065 DT denotes the
T6316 31059-31061 IN denotes of
T6315 31048-31058 JJ denotes diagnostic
T6314 31033-31036 VBD denotes was
T6313 31021-31024 NN denotes PCR
T6312 31025-31032 NN denotes product
T6311 31019-31020 DT denotes a
T6310 31016-31018 IN denotes of
T6309 31008-31015 NN denotes absence
T6308 31004-31007 DT denotes the
T6307 31002-31004 , denotes ,
T6306 30994-31002 NN denotes Tas2r120
T6305 31037-31047 VBN denotes considered
T6304 30990-30993 IN denotes For
T6303 30989-31076 sentence denotes For Tas2r120, the absence of a PCR product was considered diagnostic of the D2 allele.
T6302 30988-30989 . denotes .
T6301 30979-30981 JJ denotes RI
T6300 30975-30976 HYPH denotes /
T6299 30976-30978 NN denotes Ty
T6298 30972-30975 NN denotes BXD
T6297 30982-30988 NN denotes strain
T6296 30967-30971 DT denotes each
T6295 30964-30966 IN denotes of
T6294 30960-30963 NN denotes DNA
T6293 30952-30959 JJ denotes genomic
T6292 30947-30951 IN denotes from
T6291 30937-30946 VBN denotes amplified
T6290 30931-30936 NNS denotes cDNAs
T6289 30925-30930 NN denotes Tas2r
T6288 30922-30924 IN denotes of
T6287 30914-30921 NNS denotes digests
T6286 30903-30913 JJ denotes diagnostic
T6285 30900-30902 IN denotes in
T6284 30890-30894 VBD denotes were
T6283 30895-30899 VBN denotes used
T6282 30864-30875 NN denotes restriction
T6281 30850-30863 JJ denotes corresponding
T6280 30876-30889 NNS denotes endonucleases
T6279 30846-30849 DT denotes the
T6278 30842-30845 CC denotes and
T6277 30840-30842 , denotes ,
T6276 30830-30832 NN denotes D2
T6275 30826-30829 CC denotes and
T6274 30833-30840 NNS denotes alleles
T6273 30823-30825 NN denotes B6
T6272 30808-30822 VBD denotes differentiated
T6271 30803-30807 WDT denotes that
T6270 30787-30791 VBD denotes were
T6269 30769-30780 NN denotes restriction
T6268 30781-30786 NNS denotes sites
T6739 13004-13012 RB denotes strongly
T6738 12991-12992 -RRB- denotes )
T6737 12987-12991 NN denotes QHCl
T6736 12984-12986 NN denotes mM
T6735 12982-12983 CD denotes 1
T6734 12978-12981 IN denotes for
T6733 12972-12977 NN denotes ratio
T6732 12967-12971 NN denotes lick
T6731 12966-12967 -LRB- denotes (
T6730 12954-12959 NN denotes trait
T6729 12960-12965 NN denotes value
T6728 12950-12953 DT denotes the
T6727 12948-12950 , denotes ,
T6726 12947-12948 CD denotes 6
T6725 12936-12946 NN denotes chromosome
T6724 12932-12935 IN denotes for
T6723 12919-12927 JJ denotes interval
T6267 30762-30768 JJ denotes unique
T6266 30760-30762 , denotes ,
T6265 30792-30802 VBN denotes identified
T6264 30752-30760 JJ denotes possible
T6263 30747-30751 WRB denotes When
T6262 30746-30989 sentence denotes When possible, unique restriction sites were identified that differentiated B6 and D2 alleles, and the corresponding restriction endonucleases were used in diagnostic digests of Tas2r cDNAs amplified from genomic DNA of each BXD/Ty RI strain.
T6261 30745-30746 . denotes .
T6260 30735-30745 VBN denotes identified
T6259 30721-30734 NNS denotes polymorphisms
T6258 30717-30720 CC denotes and
T6257 30715-30717 , denotes ,
T6256 30714-30715 -RRB- denotes )
T6255 30713-30714 CD denotes 2
T6254 30708-30712 NN denotes file
T6253 30697-30707 JJ denotes Additional
T6252 30693-30696 VB denotes see
T6251 30692-30693 -LRB- denotes (
T6250 30684-30691 NNP denotes Genbank
T6249 30681-30683 IN denotes in
T6248 30671-30680 JJ denotes available
T6247 30661-30670 NNS denotes sequences
T6246 30658-30660 NN denotes B6
T6245 30655-30657 IN denotes to
T6244 30641-30645 VBD denotes were
T6243 30632-30640 NNS denotes products
T6242 30629-30631 NN denotes D2
T6241 30626-30628 IN denotes of
T6240 30646-30654 VBN denotes compared
T6239 30616-30625 NNS denotes sequences
T6238 30612-30615 DT denotes The
T6237 30611-30746 sentence denotes The sequences of D2 products were compared to B6 sequences available in Genbank (see Additional file 2), and polymorphisms identified.
T6236 30610-30611 . denotes .
T6235 30595-30605 NNP denotes Biopolymer
T6234 30586-30594 NNP denotes Medicine
T6233 30583-30585 IN denotes of
T6232 30576-30582 NNP denotes School
T6231 30567-30575 NNP denotes Maryland
T6230 30564-30566 IN denotes of
T6229 30553-30563 NNP denotes University
T6228 30606-30610 NNP denotes Core
T6227 30549-30552 DT denotes the
T6226 30546-30548 IN denotes at
T6225 30536-30545 VBN denotes sequenced
T6224 30532-30535 CC denotes and
T6223 30530-30531 -RRB- denotes )
T6222 30528-30530 NNP denotes WI
T6221 30526-30528 , denotes ,
T6220 30519-30526 NNP denotes Madison
T6219 30517-30519 , denotes ,
T6218 30510-30517 NNP denotes Promega
T6217 30509-30510 -LRB- denotes (
T6216 30504-30508 JJ denotes Easy
T6215 30503-30504 HYPH denotes -
T6214 30498-30503 NN denotes pGemT
T6213 30493-30497 IN denotes into
T6212 30478-30482 VBD denotes were
T6211 30483-30492 VBN denotes subcloned
T6210 30469-30477 NNS denotes products
T6209 30465-30468 NN denotes PCR
T6208 30464-30611 sentence denotes PCR products were subcloned into pGemT-Easy (Promega, Madison, WI) and sequenced at the University of Maryland School of Medicine Biopolymer Core.
T6207 30463-30464 . denotes .
T6206 30462-30463 -RRB- denotes )
T6205 30460-30462 NNP denotes NJ
T6204 30458-30460 , denotes ,
T6203 30448-30458 NNP denotes Plainfield
T6202 30442-30447 NNP denotes South
T6201 30440-30442 , denotes ,
T6200 30430-30440 NNP denotes Scientific
T6199 30421-30429 NNP denotes Denville
T6198 30420-30421 -LRB- denotes (
T6197 30404-30410 NNP denotes TaqPro
T6196 30393-30403 NN denotes polymerase
T6195 30383-30384 HYPH denotes -
T6194 30384-30392 NN denotes fidelity
T6193 30379-30383 JJ denotes high
T6192 30411-30419 NNP denotes Complete
T6191 30377-30378 DT denotes a
T6190 30371-30376 VBG denotes using
T6189 30369-30370 -RRB- denotes )
T6188 30366-30369 NN denotes PCR
T6125 30055-30058 NN denotes T2R
T6124 30052-30054 IN denotes of
T6123 30037-30051 NN denotes Identification
T6075 30034-30035 . denotes .
T6074 30033-30034 -RRB- denotes ]
T6073 30031-30033 CD denotes 40
T6072 30030-30031 -LRB- denotes [
T6071 30019-30021 JJ denotes RI
T6070 30015-30018 NN denotes BXD
T6069 30022-30029 NNS denotes strains
T6068 30011-30014 DT denotes the
T6067 30007-30010 IN denotes for
T6066 29990-29996 NN denotes online
T6065 29977-29989 NNP denotes Laboratories
T6064 29969-29976 NNP denotes Jackson
T6063 29997-30006 NNS denotes resources
T6062 29965-29968 DT denotes the
T6061 29960-29964 IN denotes from
T6060 29944-29948 VBD denotes were
T6059 29942-29943 CD denotes 6
T6058 29931-29941 NN denotes chromosome
T6057 29928-29930 IN denotes on
T6056 29924-29927 NN denotes QTL
T6055 29920-29923 DT denotes the
T6054 29913-29919 VB denotes refine
T6053 29910-29912 TO denotes to
T6052 29905-29909 VBN denotes used
T6051 29949-29959 VBN denotes identified
T6050 29897-29904 NNS denotes markers
T6049 29886-29896 JJ denotes Additional
T6048 29885-30035 sentence denotes Additional markers used to refine the QTL on chromosome 6 were identified from the Jackson Laboratories online resources for the BXD RI strains [40].
T6047 29884-29885 . denotes .
T6046 29878-29879 SYM denotes <
T6045 29880-29884 CD denotes 0.63
T6044 29876-29877 NN denotes p
T6043 29873-29875 IN denotes to
T6042 29866-29872 VBZ denotes refers
T6041 29855-29865 JJ denotes suggestive
T6040 29851-29854 CC denotes and
T6039 29844-29845 SYM denotes <
T6038 29846-29850 CD denotes 0.05
T6037 29842-29843 NN denotes p
T6036 29839-29841 IN denotes at
T6035 29831-29834 VBD denotes was
T6034 29835-29838 VBN denotes set
T6033 29818-29830 NN denotes Significance
T6032 29817-29885 sentence denotes Significance was set at p < 0.05 and suggestive refers to p < 0.63.
T6031 29816-29817 . denotes .
T6030 29810-29816 NNS denotes scores
T6029 29806-29809 NN denotes LRS
T6028 29802-29805 IN denotes for
T6027 29780-29792 NN denotes significance
T6026 29793-29801 NNS denotes criteria
T6025 29774-29775 HYPH denotes -
T6024 29775-29779 JJ denotes wide
T6023 29768-29774 NN denotes genome
T6022 29758-29767 VB denotes determine
T6021 29755-29757 TO denotes to
T6020 29746-29749 VBD denotes was
T6019 29744-29745 -RRB- denotes )
T6018 29739-29740 SYM denotes x
T6017 29740-29744 CD denotes 2000
T6016 29738-29739 -LRB- denotes (
T6015 29750-29754 VBN denotes used
T6014 29729-29737 NN denotes analysis
T6013 29717-29728 NN denotes Permutation
T6012 29716-29817 sentence denotes Permutation analysis (x2000) was used to determine genome-wide significance criteria for LRS scores.
T6011 29715-29716 . denotes .
T6010 29714-29715 -RRB- denotes )
T6009 29713-29714 -RRB- denotes ]
T6008 29710-29711 -LRB- denotes [
T6007 29705-29709 FW denotes e.g.
T6006 29711-29713 CD denotes 46
T6005 29703-29704 : denotes ;
T6004 29700-29703 NN denotes LRS
T6003 29699-29700 -LRB- denotes (
T6002 29683-29688 NN denotes ratio
T6001 29672-29682 NN denotes likelihood
T6000 29689-29698 NN denotes statistic
T5999 29668-29671 DT denotes the
T5998 29665-29667 IN denotes by
T5997 29653-29655 VBZ denotes is
T5996 29631-29640 JJ denotes potential
T5995 29641-29652 NN denotes association
T5994 29626-29630 DT denotes each
T5993 29623-29625 IN denotes of
T5992 29656-29664 VBN denotes measured
T5991 29610-29622 NN denotes significance
T5990 29606-29609 DT denotes The
T6506 9269-9270 . denotes .
T6505 9268-9269 -RRB- denotes )
T6504 9267-9268 NN denotes C
T6503 9266-9267 -LRB- denotes (
T6502 9262-9265 CC denotes and
T6501 9260-9261 -RRB- denotes )
T6500 9259-9260 NN denotes B
T6499 9258-9259 -LRB- denotes (
T6498 9255-9257 IN denotes in
T6497 9249-9254 DT denotes those
T6496 9246-9248 IN denotes to
T6495 9228-9233 NN denotes taste
T6494 9234-9245 NN denotes sensitivity
T6493 9223-9227 NN denotes QHCl
T6492 9220-9222 IN denotes in
T6491 9207-9219 JJ denotes intermediate
T6490 9195-9198 NN denotes BXD
T6489 9191-9194 CD denotes six
T6488 9199-9206 NNS denotes strains
T6487 9187-9190 DT denotes the
T6486 9183-9186 IN denotes for
T6485 9171-9175 NN denotes lick
T6484 9166-9170 NN denotes Mean
T6483 9164-9165 -RRB- denotes )
T6482 9176-9182 NNS denotes ratios
T6481 9163-9164 LS denotes D
T6480 9162-9163 -LRB- denotes (
T6479 9161-9270 sentence denotes (D) Mean lick ratios for the six BXD strains intermediate in QHCl taste sensitivity to those in (B) and (C).
T6478 9160-9161 . denotes .
T6477 9155-9160 NN denotes assay
T6476 9150-9154 DT denotes this
T6475 9147-9149 IN denotes in
T6474 9142-9146 NN denotes QHCl
T6473 9139-9141 IN denotes to
T6472 9129-9138 JJ denotes sensitive
T6471 9123-9128 RBS denotes least
T6470 9119-9122 VBP denotes are
T6469 9114-9118 WDT denotes that
T6468 9102-9105 NN denotes BXD
T6467 9097-9101 CD denotes five
T6466 9106-9113 NNS denotes strains
T6465 9093-9096 DT denotes the
T6464 9089-9092 IN denotes for
T6463 9077-9081 NN denotes lick
T6462 9072-9076 NN denotes Mean
T6461 9070-9071 -RRB- denotes )
T6460 9082-9088 NNS denotes ratios
T6459 9069-9070 LS denotes C
T6458 9068-9069 -LRB- denotes (
T6457 9067-9161 sentence denotes (C) Mean lick ratios for the five BXD strains that are least sensitive to QHCl in this assay.
T6456 9066-9067 . denotes .
T6455 9061-9066 NN denotes assay
T6454 9056-9060 DT denotes this
T6453 9053-9055 IN denotes in
T6452 9048-9052 NN denotes QHCl
T6451 9045-9047 IN denotes to
T6450 9035-9044 JJ denotes sensitive
T6449 9030-9034 RBS denotes most
T6448 9026-9029 VBP denotes are
T6447 9021-9025 WDT denotes that
T6446 9009-9012 NN denotes BXD
T6445 9005-9008 CD denotes six
T6444 9013-9020 NNS denotes strains
T6443 9001-9004 DT denotes the
T6442 8997-9000 IN denotes for
T6441 8985-8989 NN denotes lick
T6440 8980-8984 NN denotes Mean
T6439 8978-8979 -RRB- denotes )
T6438 8990-8996 NNS denotes ratios
T6437 8977-8978 LS denotes B
T6436 8976-8977 -LRB- denotes (
T6435 8975-9067 sentence denotes (B) Mean lick ratios for the six BXD strains that are most sensitive to QHCl in this assay.
T6434 8974-8975 . denotes .
T6433 8970-8974 NN denotes QHCL
T6432 8967-8969 NN denotes mM
T6431 8965-8966 CD denotes 1
T6430 8962-8964 IN denotes to
T6429 8952-8961 JJ denotes sensitive
T6428 8947-8951 RBS denotes most
T6427 8944-8946 IN denotes to
T6426 8934-8943 JJ denotes sensitive
T6425 8928-8933 JJS denotes least
T6424 8923-8927 IN denotes from
T6423 8917-8922 NN denotes order
T6422 8914-8916 IN denotes in
T6421 8907-8913 VBN denotes listed
T6420 8903-8906 CC denotes and
T6419 8901-8903 , denotes ,
T6418 8886-8895 JJ denotes different
T6417 8896-8901 NN denotes color
T6416 8884-8885 DT denotes a
T6415 8881-8883 IN denotes by
T6414 8866-8868 VBZ denotes is
T6413 8855-8858 NN denotes BXD
T6412 8859-8865 NN denotes strain
T6411 8850-8854 DT denotes each
T6410 8848-8850 , denotes ,
T6409 8847-8848 NN denotes D
T6408 8843-8846 CC denotes and
T6407 8841-8843 , denotes ,
T6406 8840-8841 NN denotes C
T6405 8838-8840 , denotes ,
T6404 8837-8838 NN denotes B
T5989 29605-29716 sentence denotes The significance of each potential association is measured by the likelihood ratio statistic (LRS; e.g. [46]).
T5988 29604-29605 . denotes .
T5987 29593-29599 NN denotes marker
T5986 29600-29604 NNS denotes loci
T5985 29584-29592 JJ denotes adjacent
T5984 29581-29583 IN denotes of
T5983 29576-29580 NN denotes pair
T5982 29571-29575 DT denotes each
T5981 29563-29570 IN denotes between
T5980 29547-29555 NN denotes analysis
T5979 29556-29562 NNS denotes points
T5978 29538-29546 JJ denotes multiple
T5977 29535-29537 IN denotes at
T5976 29533-29534 -RRB- denotes )
T5975 29530-29533 NN denotes QTL
T5974 29529-29530 -LRB- denotes (
T5973 29517-29522 NN denotes trait
T5972 29504-29516 JJ denotes quantitative
T5971 29491-29503 JJ denotes hypothetical
T5970 29523-29528 NN denotes locus
T5969 29489-29490 DT denotes a
T5968 29486-29488 IN denotes of
T5967 29477-29485 NN denotes genotype
T5966 29468-29476 VBN denotes expected
T5965 29464-29467 CC denotes and
T5964 29462-29463 -RRB- denotes )
T5963 29456-29462 NNS denotes ratios
T5962 29451-29455 NN denotes lick
T5961 29450-29451 -LRB- denotes (
T5960 29443-29449 NNS denotes values
T5959 29437-29442 NN denotes trait
T5958 29429-29436 IN denotes between
T5957 29417-29428 NN denotes association
T5956 29413-29416 DT denotes the
T5955 29403-29412 VBZ denotes evaluates
T5954 29396-29402 NN denotes method
T5953 29391-29395 DT denotes This
T5952 29390-29605 sentence denotes This method evaluates the association between trait values (lick ratios) and expected genotype of a hypothetical quantitative trait locus (QTL) at multiple analysis points between each pair of adjacent marker loci.
T5951 29389-29390 . denotes .
T5950 29376-29379 VBD denotes was
T5949 29380-29389 VBN denotes conducted
T5948 29359-29367 NN denotes interval
T5947 29368-29375 NN denotes mapping
T5946 29352-29358 NN denotes Simple
T5945 29351-29390 sentence denotes Simple interval mapping was conducted.
T5944 29350-29351 . denotes .
T5943 29349-29350 -RRB- denotes ]
T5942 29347-29349 CD denotes 45
T5941 29346-29347 -LRB- denotes [
T5940 29331-29338 NNP denotes Science
T5939 29324-29330 NNP denotes Health
T5938 29314-29323 NNP denotes Tennessee
T5937 29311-29313 IN denotes of
T5936 29339-29345 NNP denotes Center
T5935 29300-29310 NNP denotes University
T5934 29298-29300 , denotes ,
T5933 29287-29289 NNP denotes W.
T5932 29290-29298 NNP denotes Williams
T5931 29280-29286 NNP denotes Robert
T5930 29277-29279 IN denotes by
T5929 29270-29276 VBN denotes shared
T5928 29256-29264 NN denotes genotype
T5927 29265-29269 NNS denotes data
T5926 29252-29255 NN denotes BXD
T5925 29248-29251 CC denotes and
T5924 29246-29248 , denotes ,
T5923 29245-29246 -RRB- denotes )
T5922 29244-29245 -RRB- denotes ]
T5921 29241-29242 -LRB- denotes [
T5920 29237-29240 NN denotes QTX
T5919 29229-29236 NN denotes Manager
T5918 29225-29228 NN denotes Map
T5917 29242-29244 CD denotes 38
T5916 29224-29225 -LRB- denotes (
T5915 29215-29223 NN denotes software
T5914 29205-29214 JJ denotes available
T5913 29198-29204 RB denotes freely
T5912 29192-29197 VBG denotes using
T5911 29187-29191 NNS denotes mice
T5910 29183-29186 NN denotes BXD
T5764 28491-28495 NN denotes Lick
T5763 28490-28689 sentence denotes Lick ratios for individual mice to sucrose were generally ~1.0 (data not shown), indicating that either concentration of this compound was licked at a similar rate to water by these thirsty animals.
T5762 28489-28490 . denotes .
T5761 28484-28489 NN denotes ANOVA
T5760 28476-28483 NNS denotes effects
T5759 28471-28475 JJ denotes main
T5758 28465-28470 VBG denotes using
T5757 28455-28459 VBD denotes were
T5756 28453-28454 -RRB- denotes )
T5755 28451-28453 CD denotes 1A
T5754 28446-28450 NN denotes Fig.
T5753 28445-28446 -LRB- denotes (
T5752 28460-28464 VBN denotes made
T5751 28430-28432 NN denotes D2
T5750 28426-28429 CC denotes vs.
T5749 28433-28444 NNS denotes comparisons
T5748 28423-28425 NN denotes B6
T5747 28422-28490 sentence denotes B6 vs. D2 comparisons (Fig. 1A) were made using main effects ANOVA.
T5746 28421-28422 . denotes .
T5745 28415-28421 NN denotes strain
T5744 28410-28414 DT denotes each
T5743 28406-28409 IN denotes for
T5742 28392-28396 VBD denotes were
T5741 28397-28405 VBN denotes prepared
T5740 28386-28391 NNS denotes means
T5739 28382-28385 CC denotes and
T5738 28380-28382 , denotes ,
T5737 28365-28375 JJ denotes individual
T5736 28376-28380 NNS denotes mice
T5735 28361-28364 DT denotes all
T5734 28357-28360 IN denotes for
T5733 28343-28347 VBD denotes were
T5732 28334-28342 NN denotes stimulus
T5731 28329-28333 DT denotes each
T5730 28325-28328 IN denotes for
T5729 28348-28356 VBN denotes compiled
T5728 28320-28324 NNS denotes data
T5727 28314-28319 NN denotes ratio
T5726 28309-28313 JJ denotes Lick
T5725 28308-28422 sentence denotes Lick ratio data for each stimulus were compiled for all individual mice, and means were prepared for each strain.
T5724 28307-28308 . denotes .
T5723 28294-28298 NN denotes test
T5722 28299-28307 NNS denotes sessions
T5721 28289-28293 DT denotes both
T5720 28282-28288 IN denotes during
T5719 28269-28274 NN denotes water
T5718 28275-28281 NNS denotes trials
T5717 28265-28268 DT denotes the
T5716 28260-28264 IN denotes from
T5715 28249-28251 VBZ denotes is
T5714 28243-28248 NN denotes water
T5713 28240-28242 IN denotes to
T5712 28234-28239 NNS denotes licks
T5711 28231-28233 IN denotes of
T5710 28252-28259 VBN denotes derived
T5709 28216-28223 JJ denotes average
T5708 28224-28230 NN denotes number
T5707 28212-28215 DT denotes the
T5706 28208-28211 CC denotes and
T5705 28199-28207 NN denotes stimulus
T5704 28196-28198 IN denotes of
T5703 28176-28181 VBN denotes given
T5702 28182-28195 NN denotes concentration
T5701 28174-28175 DT denotes a
T5700 28169-28170 SYM denotes x
T5699 28171-28173 VBZ denotes is
T5698 28163-28168 WRB denotes where
T5697 28161-28162 -RRB- denotes )
T5696 28156-28161 NN denotes water
T5695 28153-28155 IN denotes to
T5694 28147-28152 NNS denotes licks
T5693 28144-28146 IN denotes of
T5692 28129-28136 JJ denotes average
T5691 28137-28143 NN denotes number
T5690 28128-28129 SYM denotes /
T5689 28126-28127 SYM denotes x
T5688 28118-28126 NN denotes stimulus
T5687 28115-28117 IN denotes to
T5686 28109-28114 NNS denotes licks
T5685 28106-28108 IN denotes of
T5684 28099-28105 NN denotes number
T5683 28091-28098 JJ denotes average
T5682 28090-28091 -LRB- denotes (
T5681 28079-28083 NN denotes lick
T5680 28084-28089 NN denotes ratio
T5679 28075-28078 DT denotes the
T5678 28065-28070 NN denotes mouse
T5677 28060-28064 DT denotes each
T5676 28056-28059 IN denotes for
T5675 28047-28055 VBN denotes computed
T5674 28042-28046 DT denotes each
T5673 28038-28041 IN denotes for
T5672 28071-28074 VBD denotes was
T5671 28020-28029 JJ denotes dependent
T5670 28030-28037 NN denotes measure
T5669 28016-28019 DT denotes The
T5668 28015-28308 sentence denotes The dependent measure for each computed for each mouse was the lick ratio (average number of licks to stimulusx /average number of licks to water) where x is a given concentration of stimulus and the average number of licks to water is derived from the water trials during both test sessions.
T5667 28014-28015 . denotes .
T5666 28009-28014 NN denotes order
T5665 28002-28008 JJ denotes random
T5664 27999-28001 IN denotes in
T5663 27987-27991 RB denotes also
T5662 27982-27986 VBD denotes were
T5661 27992-27998 VBN denotes tested
T5660 27977-27981 NNS denotes mice
T5659 27966-27976 JJ denotes Individual
T5658 27965-28015 sentence denotes Individual mice were also tested in random order.
T5657 27964-27965 . denotes .
T5656 27959-27964 NN denotes order
T5655 27952-27958 JJ denotes random
T5654 27949-27951 IN denotes in
T5653 27943-27948 NN denotes water
T5652 27933-27942 JJ denotes distilled
T5651 27930-27932 IN denotes of
T5650 27916-27929 NNS denotes presentations
T5649 27911-27915 CD denotes four
T5648 27906-27910 CC denotes plus
T5647 27897-27905 NN denotes stimulus
T5646 27894-27896 IN denotes of
T5645 27880-27893 NN denotes concentration
T5644 27875-27879 DT denotes each
T5643 27872-27874 IN denotes of
T5642 27862-27871 VBD denotes consisted
T5641 27856-27861 NN denotes block
T5640 27851-27855 DT denotes Each
T5639 27850-27965 sentence denotes Each block consisted of each concentration of stimulus plus four presentations of distilled water in random order.
T5638 27849-27850 . denotes .
T5637 27842-27849 NN denotes session
T5636 27837-27841 NN denotes test
T5635 27833-27836 IN denotes per
T5634 27817-27825 JJ denotes possible
T5633 27826-27832 NNS denotes trials
T5632 27814-27816 CD denotes 24
T5631 27811-27813 IN denotes of
T5630 27805-27810 NN denotes total
T5629 27803-27804 DT denotes a
T6187 30365-30366 -LRB- denotes (
T6186 30350-30355 NN denotes chain
T6185 30356-30364 NN denotes reaction
T6184 30339-30349 NN denotes polymerase
T6183 30336-30338 IN denotes by
T6182 30334-30335 -RRB- denotes )
T6181 30332-30334 NNP denotes ME
T6180 30330-30332 , denotes ,
T6179 30324-30330 NNP denotes Harbor
T6178 30320-30323 NNP denotes Bar
T6177 30318-30320 , denotes ,
T6176 30306-30318 NNP denotes Laboratories
T6175 30298-30305 NNP denotes Jackson
T6174 30297-30298 -LRB- denotes (
T6173 30285-30292 JJ denotes genomic
T6172 30282-30284 JJ denotes RI
T6171 30278-30281 NN denotes BXD
T6170 30275-30277 CC denotes or
T6169 30293-30296 NN denotes DNA
T6168 30272-30274 NN denotes D2
T6167 30267-30271 IN denotes from
T6166 30253-30256 VBD denotes was
T6165 30241-30242 HYPH denotes -
T6164 30242-30246 NN denotes exon
T6163 30235-30241 JJ denotes single
T6162 30247-30252 NN denotes Tas2r
T6161 30230-30234 DT denotes each
T6160 30227-30229 IN denotes of
T6159 30218-30226 NN denotes sequence
T6158 30209-30217 VBG denotes flanking
T6157 30206-30208 IN denotes of
T6156 30203-30205 NN denotes kb
T6155 30200-30202 CD denotes 50
T6154 30199-30200 SYM denotes ~
T6153 30194-30198 CC denotes plus
T6152 30257-30266 VBN denotes amplified
T6151 30179-30185 NN denotes coding
T6150 30186-30193 NNS denotes regions
T6149 30172-30178 JJ denotes Entire
T6148 30171-30464 sentence denotes Entire coding regions plus ~50 kb of flanking sequence of each single-exon Tas2r was amplified from D2 or BXD RI genomic DNA (Jackson Laboratories, Bar Harbor, ME) by polymerase chain reaction (PCR) using a high-fidelity polymerase TaqPro Complete (Denville Scientific, South Plainfield, NJ).
T6147 30170-30171 . denotes .
T6146 30161-30163 NN denotes B6
T6145 30154-30160 JJ denotes public
T6144 30164-30170 NN denotes genome
T6143 30150-30153 DT denotes the
T6142 30147-30149 IN denotes on
T6141 30144-30146 CC denotes or
T6140 30129-30133 NN denotes cDNA
T6139 30134-30143 NNS denotes sequences
T6138 30124-30125 HYPH denotes /
T6137 30125-30128 NN denotes SvJ
T6136 30121-30124 CD denotes 129
T6135 30118-30120 CC denotes or
T6134 30108-30114 NN denotes mTas2r
T6133 30115-30117 NN denotes B6
T6132 30098-30107 VBN denotes published
T6131 30095-30097 IN denotes on
T6130 30084-30088 VBD denotes were
T6129 30089-30094 VBN denotes based
T6128 30067-30083 NNS denotes Oligonucleotides
T6127 30066-30171 sentence denotes Oligonucleotides were based on published mTas2r B6 or 129/SvJ cDNA sequences or on the public B6 genome.
T6126 30059-30066 NNS denotes alleles
T5628 27799-27802 IN denotes for
T5627 27797-27799 , denotes ,
T5626 27791-27797 NNS denotes trials
T5625 27789-27790 CD denotes 8
T5624 27786-27788 IN denotes of
T5623 27779-27785 NNS denotes blocks
T5622 27777-27778 CD denotes 3
T5621 27774-27776 IN denotes in
T5620 27759-27763 VBD denotes were
T5619 27764-27773 VBN denotes presented
T5618 27752-27758 NNS denotes trials
T5617 27743-27751 NN denotes Stimulus
T5616 27742-27850 sentence denotes Stimulus trials were presented in 3 blocks of 8 trials, for a total of 24 possible trials per test session.
T5615 27741-27742 . denotes .
T5614 27740-27741 -RRB- denotes ]
T5613 27733-27740 NN denotes sucrose
T5612 27727-27730 CD denotes 0.1
T5611 27723-27726 CC denotes and
T5610 27731-27732 NN denotes M
T5609 27718-27722 CD denotes 0.01
T5608 27714-27717 CC denotes and
T5607 27712-27714 , denotes ,
T5606 27711-27712 -RRB- denotes )
T5605 27695-27706 JJ denotes unpublished
T5604 27707-27711 NNS denotes data
T5603 27694-27695 -LRB- denotes (
T5602 27689-27693 NN denotes PROP
T5601 27683-27685 CD denotes 10
T5600 27679-27682 CC denotes and
T5599 27686-27688 NN denotes mM
T5598 27677-27678 CD denotes 3
T5597 27675-27677 , denotes ,
T5596 27673-27675 NN denotes DB
T5595 27668-27669 CD denotes 3
T5594 27664-27667 CC denotes and
T5593 27670-27672 NN denotes mM
T5592 27662-27663 CD denotes 1
T5591 27660-27662 , denotes ,
T5590 27651-27652 CD denotes 3
T5589 27647-27650 CC denotes and
T5588 27653-27655 NN denotes mM
T5587 27645-27646 CD denotes 1
T5586 27656-27660 NN denotes QHCl
T5585 27644-27645 -LRB- denotes [
T5584 27630-27635 NN denotes taste
T5583 27620-27629 JJ denotes different
T5582 27636-27643 NNS denotes stimuli
T5581 27618-27619 CD denotes 4
T5580 27615-27617 IN denotes of
T5579 27610-27614 DT denotes each
T5578 27595-27609 NNS denotes concentrations
T5577 27593-27594 CD denotes 2
T5576 27588-27592 IN denotes with
T5575 27576-27580 VBD denotes were
T5574 27581-27587 VBN denotes tested
T5573 27571-27575 NNS denotes Mice
T5572 27570-27742 sentence denotes Mice were tested with 2 concentrations each of 4 different taste stimuli [1 and 3 mM QHCl, 1 and 3 mM DB, 3 and 10 mM PROP (unpublished data), and 0.01 and 0.1 M sucrose].
T5571 27569-27570 . denotes .
T5570 27556-27559 VBD denotes was
T5569 27560-27569 VBN denotes presented
T5568 27545-27549 JJ denotes next
T5567 27550-27555 NN denotes trial
T5566 27541-27544 DT denotes the
T5565 27537-27540 CC denotes and
T5564 27535-27536 NN denotes s
T5563 27532-27534 CD denotes 10
T5562 27528-27531 IN denotes for
T5561 27513-27520 NN denotes shutter
T5560 27509-27512 DT denotes the
T5559 27507-27509 , denotes ,
T5558 27499-27507 NN denotes interval
T5557 27494-27498 DT denotes this
T5556 27487-27493 IN denotes during
T5555 27473-27476 RB denotes not
T5554 27469-27472 VBD denotes was
T5553 27463-27468 NN denotes trial
T5552 27461-27462 DT denotes a
T5551 27477-27486 VBN denotes initiated
T5550 27458-27460 IN denotes if
T5549 27456-27457 , denotes ;
T5442 26967-26969 CD denotes 24
T5441 26961-26966 IN denotes after
T5440 26959-26961 , denotes ,
T5439 27013-27018 VBN denotes given
T5438 26952-26959 RB denotes Briefly
T5437 26951-27126 sentence denotes Briefly, after 24 hours of water deprivation, naïve mice are given a single 20-minute trial consisting of access to a single bottle of distilled water (sipper tube training).
T5436 26950-26951 . denotes .
T5435 26949-26950 -RRB- denotes ]
T5434 26946-26947 , denotes ,
T5433 26944-26946 CD denotes 29
T5432 26947-26949 CD denotes 37
T5431 26943-26944 -LRB- denotes [
T5430 26935-26942 RBR denotes earlier
T5429 26925-26934 VBN denotes described
T5428 26919-26924 DT denotes those
T5427 26916-26918 IN denotes to
T5426 26908-26915 JJ denotes similar
T5425 26903-26907 VBD denotes were
T5424 26892-26902 NNS denotes procedures
T5423 26884-26891 JJ denotes Testing
T5422 26883-26951 sentence denotes Testing procedures were similar to those described earlier [29,37].
T5421 26882-26883 . denotes .
T5420 26881-26882 -RRB- denotes )
T5419 26879-26881 NNP denotes FL
T5418 26867-26878 NNP denotes Tallahassee
T5417 26865-26867 , denotes ,
T5416 26861-26865 NNP denotes Inc.
T5415 26859-26861 , denotes ,
T5414 26848-26859 NNPS denotes Instruments
T5413 26842-26847 NNP denotes DiLog
T5412 26841-26842 -LRB- denotes (
T5411 26826-26829 CD denotes 160
T5410 26825-26826 HYPH denotes -
T5409 26823-26825 NN denotes MS
T5408 26817-26822 NNP denotes Davis
T5407 26807-26816 JJ denotes available
T5406 26794-26806 RB denotes commercially
T5405 26830-26840 NN denotes gustometer
T5404 26790-26793 DT denotes the
T5403 26787-26789 IN denotes in
T5402 26772-26776 VBD denotes were
T5401 26777-26786 VBN denotes conducted
T5400 26755-26765 JJ denotes behavioral
T5399 26766-26771 NNS denotes tests
T5398 26751-26754 DT denotes All
T5397 26750-26883 sentence denotes All behavioral tests were conducted in the commercially available Davis MS-160 gustometer (DiLog Instruments, Inc., Tallahassee FL).
T5396 26745-26750 NNS denotes tests
T5395 26737-26738 HYPH denotes -
T5394 26738-26744 NN denotes access
T5393 26732-26737 JJ denotes Brief
T5330 26729-26730 . denotes .
T5329 26716-26719 NNP denotes Use
T5328 26712-26715 CC denotes and
T5327 26707-26711 NNP denotes care
T5326 26700-26706 NNP denotes Animal
T5325 26686-26699 NNP denotes Institutional
T5324 26680-26685 NNP denotes UTHSC
T5323 26720-26729 NNP denotes Committee
T5322 26676-26679 DT denotes the
T5321 26673-26675 IN denotes by
T5320 26659-26663 VBD denotes were
T5319 26664-26672 VBN denotes approved
T5318 26642-26648 NN denotes animal
T5317 26649-26658 NNS denotes protocols
T5316 26638-26641 DT denotes All
T5315 26637-26730 sentence denotes All animal protocols were approved by the UTHSC Institutional Animal care and Use Committee.
T5314 26636-26637 . denotes .
T5313 26625-26636 NN denotes temperature
T5312 26620-26624 NN denotes room
T5311 26617-26619 IN denotes at
T5310 26602-26606 VBD denotes were
T5309 26607-26616 VBN denotes presented
T5308 26588-26593 NN denotes taste
T5307 26594-26601 NNS denotes stimuli
T5909 29180-29182 IN denotes on
T5908 29166-29169 VBD denotes was
T5907 29170-29179 VBN denotes conducted
T5906 29157-29165 NN denotes analysis
T5905 29149-29156 NN denotes Linkage
T5904 29148-29351 sentence denotes Linkage analysis was conducted on BXD mice using freely available software (Map Manager QTX [38]), and BXD genotype data shared by Robert W. Williams, University of Tennessee Health Science Center [45].
T5903 29141-29148 NN denotes mapping
T5902 29137-29140 NN denotes QTL
T5884 29134-29135 . denotes .
T5883 29133-29134 -RRB- denotes ]
T5882 29131-29133 CD denotes 37
T5881 29130-29131 -LRB- denotes [
T5880 29110-29120 JJ denotes particular
T5879 29121-29129 NN denotes stimulus
T5878 29108-29109 DT denotes a
T5877 29105-29107 IN denotes of
T5876 29090-29104 NNS denotes concentrations
T5875 29084-29089 IN denotes among
T5874 29072-29083 VB denotes distinguish
T5873 29069-29071 CC denotes or
T5872 29058-29061 MD denotes can
T5871 29053-29057 NNS denotes mice
T5870 29062-29068 VB denotes detect
T5869 29048-29052 IN denotes that
T5868 29039-29047 NN denotes evidence
T5867 29036-29038 DT denotes no
T5866 29027-29032 EX denotes there
T5865 29025-29026 : denotes ;
T5864 29020-29025 NNS denotes clues
T5863 29010-29019 JJ denotes olfactory
T5862 29007-29009 IN denotes on
T5861 29001-29006 VBN denotes based
T5860 28989-28994 NN denotes taste
T5859 28995-29000 NNS denotes tests
T5858 28981-28982 HYPH denotes -
T5857 28982-28988 NN denotes access
T5856 28976-28981 JJ denotes brief
T5855 28973-28975 IN denotes in
T5854 28955-28966 JJ denotes adulterated
T5853 28951-28954 CC denotes vs.
T5852 28967-28972 NN denotes water
T5851 28941-28950 JJ denotes distilled
T5850 28929-28933 NNS denotes mice
T5849 28934-28940 VBP denotes detect
T5848 28924-28928 IN denotes that
T5847 28915-28923 NN denotes evidence
T5846 28910-28914 DT denotes some
T5845 28901-28906 EX denotes there
T5844 28907-28909 VBZ denotes is
T5843 28898-28900 IN denotes as
T5842 28896-28898 , denotes ,
T5841 28888-28889 '' denotes "
T5840 28879-28888 JJ denotes non-water
T5839 28890-28896 NNS denotes trials
T5838 28878-28879 `` denotes "
T5837 28875-28877 IN denotes on
T5836 28866-28874 NN denotes sampling
T5835 28856-28865 VB denotes encourage
T5834 28853-28855 TO denotes to
T5833 29033-29035 VBZ denotes is
T5832 28844-28847 VBD denotes was
T5831 28848-28852 VBN denotes done
T5830 28839-28843 DT denotes This
T5829 28838-29135 sentence denotes This was done to encourage sampling on "non-water" trials, as there is some evidence that mice detect distilled vs. adulterated water in brief-access taste tests based on olfactory clues; there is no evidence that mice can detect or distinguish among concentrations of a particular stimulus [37].
T5828 28837-28838 . denotes .
T5827 28830-28837 RB denotes further
T5826 28817-28820 RB denotes not
T5825 28821-28829 VBN denotes analyzed
T5824 28807-28816 RB denotes therefore
T5823 28803-28806 CC denotes and
T5822 28801-28803 , denotes ,
T5821 28796-28801 NN denotes water
T5820 28791-28795 IN denotes than
T5819 28772-28779 JJ denotes sensory
T5818 28780-28790 NNS denotes properties
T5817 28762-28771 JJ denotes different
T5816 28758-28761 VBZ denotes has
T5815 28753-28757 WDT denotes that
T5814 28749-28752 CD denotes one
T5813 28742-28748 CC denotes albeit
T5812 28740-28742 , denotes ,
T5811 28730-28731 '' denotes "
T5810 28723-28730 JJ denotes neutral
T5809 28722-28723 `` denotes "
T5808 28732-28740 NN denotes stimulus
T5807 28720-28721 DT denotes a
T5806 28717-28719 IN denotes as
T5805 28704-28707 VBD denotes was
T5804 28708-28716 VBN denotes intended
T5803 28695-28703 NN denotes stimulus
T5802 28690-28694 DT denotes This
T5801 28689-28838 sentence denotes This stimulus was intended as a "neutral" stimulus, albeit one that has different sensory properties than water, and therefore not analyzed further.
T5800 28688-28689 . denotes .
T5799 28673-28680 JJ denotes thirsty
T5798 28681-28688 NNS denotes animals
T5797 28667-28672 DT denotes these
T5796 28664-28666 IN denotes by
T5795 28658-28663 NN denotes water
T5794 28655-28657 IN denotes to
T5793 28642-28649 JJ denotes similar
T5792 28650-28654 NN denotes rate
T5791 28640-28641 DT denotes a
T5790 28637-28639 IN denotes at
T5789 28626-28629 VBD denotes was
T5788 28617-28625 NN denotes compound
T5787 28612-28616 DT denotes this
T5786 28609-28611 IN denotes of
T5785 28595-28608 NN denotes concentration
T5784 28588-28594 CC denotes either
T5783 28630-28636 VBN denotes licked
T5782 28583-28587 IN denotes that
T5781 28572-28582 VBG denotes indicating
T5780 28570-28572 , denotes ,
T5779 28569-28570 -RRB- denotes )
T5778 28560-28563 RB denotes not
T5777 28555-28559 NNS denotes data
T5776 28564-28569 VBN denotes shown
T5775 28554-28555 -LRB- denotes (
T5774 28550-28553 CD denotes 1.0
T5773 28549-28550 SYM denotes ~
T5772 28539-28548 RB denotes generally
T5771 28526-28533 NN denotes sucrose
T5770 28523-28525 IN denotes to
T5769 28518-28522 NNS denotes mice
T5768 28507-28517 JJ denotes individual
T5767 28503-28506 IN denotes for
T5766 28534-28538 VBD denotes were
T5765 28496-28502 NNS denotes ratios
T5306 26584-26587 DT denotes all
T5305 26580-26583 CC denotes and
T5304 26578-26580 , denotes ,
T5303 26573-26578 NN denotes water
T5302 26563-26572 JJ denotes distilled
T5301 26557-26562 VBG denotes using
T5300 26551-26556 RB denotes daily
T5299 26545-26550 RB denotes fresh
T5298 26535-26539 VBD denotes were
T5297 26526-26534 NN denotes solution
T5296 26521-26525 DT denotes each
T5295 26518-26520 IN denotes of
T5294 26540-26544 VBN denotes made
T5293 26503-26517 NNS denotes Concentrations
T5292 26502-26637 sentence denotes Concentrations of each solution were made fresh daily using distilled water, and all taste stimuli were presented at room temperature.
T5291 26501-26502 . denotes .
T5290 26500-26501 -RRB- denotes )
T5289 26498-26500 NNP denotes MO
T5288 26496-26498 , denotes ,
T5287 26491-26496 NNP denotes Louis
T5286 26487-26490 NNP denotes St.
T5285 26485-26486 : denotes ;
T5284 26472-26479 NNP denotes Aldrich
T5283 26480-26485 NNP denotes Corp.
T5282 26466-26471 NNP denotes Sigma
T5281 26465-26466 -LRB- denotes (
T5280 26451-26464 NN denotes hydrochloride
T5279 26443-26450 NN denotes quinine
T5278 26439-26442 CC denotes and
T5277 26421-26422 HYPH denotes -
T5276 26420-26421 NN denotes n
T5275 26419-26420 HYPH denotes -
T5274 26422-26438 NN denotes propylthiouracil
T5273 26418-26419 CD denotes 6
T5272 26416-26418 , denotes ,
T5271 26408-26416 NN denotes benzoate
T5270 26397-26407 NN denotes denatonium
T5269 26395-26397 , denotes ,
T5268 26388-26395 NN denotes Sucrose
T5267 26386-26388 : denotes :
T5266 26377-26386 NNS denotes chemicals
T5265 26370-26371 HYPH denotes -
T5264 26371-26376 NN denotes grade
T5263 26363-26370 NN denotes reagent
T5262 26358-26362 IN denotes from
T5261 26348-26352 VBD denotes were
T5260 26337-26347 NN denotes experiment
T5259 26332-26336 DT denotes this
T5258 26329-26331 IN denotes in
T5257 26324-26328 VBN denotes used
T5256 26353-26357 VBN denotes made
T5255 26316-26323 NNS denotes stimuli
T5254 26310-26315 NN denotes Taste
T5253 26309-26502 sentence denotes Taste stimuli used in this experiment were made from reagent-grade chemicals: Sucrose, denatonium benzoate, 6-n-propylthiouracil and quinine hydrochloride (Sigma Aldrich Corp.; St. Louis, MO).
T5252 26308-26309 . denotes .
T5251 26307-26308 -RRB- denotes )
T5250 26296-26302 NN denotes rodent
T5249 26291-26295 CD denotes 8640
T5248 26284-26290 NNP denotes Teklad
T5247 26303-26307 NN denotes diet
T5246 26283-26284 -LRB- denotes (
T5245 26278-26282 NN denotes food
T5244 26270-26277 FW denotes libitum
T5243 26267-26269 FW denotes ad
T5242 26263-26266 CC denotes and
T5241 26255-26262 NN denotes bedding
T5240 26246-26254 NN denotes woodchip
T5239 26241-26245 IN denotes with
T5238 26227-26234 NN denotes shoebox
T5237 26235-26240 NNS denotes cages
T5236 26218-26226 JJ denotes standard
T5235 26215-26217 IN denotes in
T5234 26195-26207 RB denotes individually
T5233 26190-26194 VBD denotes were
T5232 26185-26189 NNS denotes mice
T5231 26183-26185 , denotes ,
T5230 26176-26183 NN denotes testing
T5229 26173-26175 IN denotes of
T5228 26168-26172 NN denotes time
T5227 26208-26214 VBN denotes housed
T5225 26164-26309 sentence denotes At time of testing, mice were individually housed in standard shoebox cages with woodchip bedding and ad libitum food (Teklad 8640 rodent diet).
T5224 26163-26164 . denotes .
T5223 26158-26163 NNP denotes UTHSC
T5222 26155-26157 IN denotes at
T5221 26149-26154 NNS denotes pairs
T5220 26142-26148 NN denotes mating
T5219 26137-26141 IN denotes from
T5218 26132-26136 VBN denotes bred
T5217 26127-26131 VBD denotes were
T5216 26124-26126 CC denotes or
T5215 26122-26124 , denotes ,
T5214 26121-26122 -RRB- denotes )
T5213 26119-26121 NNP denotes ME
T5212 26117-26119 , denotes ,
T5211 26111-26117 NNP denotes Harbor
T5210 26107-26110 NNP denotes Bar
T5209 26106-26107 -LRB- denotes (
T5208 26093-26105 NNP denotes Laboratories
T5207 26085-26092 NNP denotes Jackson
T5206 26080-26084 IN denotes from
T5205 26064-26070 RB denotes either
T5204 26059-26063 VBD denotes were
T5203 26071-26079 VBN denotes obtained
T5202 26054-26058 NNS denotes mice
T5201 26050-26053 DT denotes All
T5200 26049-26164 sentence denotes All mice were either obtained from Jackson Laboratories (Bar Harbor, ME), or were bred from mating pairs at UTHSC.
T5199 26048-26049 . denotes .
T5198 26047-26048 -RRB- denotes )
T5197 26043-26045 , denotes ,
T5196 26041-26043 CD denotes 33
T5195 26039-26041 , denotes ,
T5194 26037-26039 CD denotes 32
T5193 26035-26037 , denotes ,
T5192 26033-26035 CD denotes 31
T5191 26031-26033 , denotes ,
T5190 26029-26031 CD denotes 29
T5189 26027-26029 , denotes ,
T5188 26025-26027 CD denotes 27
T5187 26023-26025 , denotes ,
T5186 26021-26023 CD denotes 24
T5185 26019-26021 , denotes ,
T5184 26017-26019 CD denotes 21
T5183 26015-26017 , denotes ,
T5182 26013-26015 CD denotes 20
T5181 26011-26013 , denotes ,
T5180 26009-26011 CD denotes 15
T5179 26007-26009 , denotes ,
T5178 26005-26007 CD denotes 14
T5177 26003-26005 , denotes ,
T5176 26001-26003 CD denotes 13
T5175 25999-26001 , denotes ,
T5174 25997-25999 CD denotes 11
T5173 25995-25997 , denotes ,
T5172 25994-25995 CD denotes 6
T5171 25992-25994 , denotes ,
T5170 25991-25992 CD denotes 5
T5169 25989-25991 , denotes ,
T5168 25988-25989 CD denotes 2
T5167 25986-25988 , denotes ,
T5166 26045-26047 CD denotes 34
T5165 25985-25986 CD denotes 1
T5164 25984-25985 -LRB- denotes (
T5163 25971-25977 JJ denotes unique
T5162 25978-25983 NNS denotes lines
T5161 25968-25970 CD denotes 17
T5160 25963-25967 IN denotes from
T5159 25961-25962 -RRB- denotes )
T5158 25954-25961 NNS denotes females
T5157 25951-25953 CD denotes 26
T5156 25949-25951 , denotes ,
T5155 25941-25943 CD denotes 64
T5154 25939-25940 , denotes ;
T5153 25935-25939 NN denotes line
T5152 25933-25934 SYM denotes /
T5151 25929-25930 SYM denotes =
T5150 25931-25932 CD denotes 5
T5149 25921-25928 NN denotes average
T5148 25944-25949 NNS denotes males
T5147 25920-25921 -LRB- denotes (
T5146 25908-25914 JJ denotes inbred
T5145 25896-25907 JJ denotes recombinant
T5144 25915-25919 NNS denotes mice
T5143 25892-25893 HYPH denotes /
T5142 25889-25892 NN denotes BXD
T5141 25893-25895 NN denotes Ty
T5140 25886-25888 CD denotes 90
T5139 25882-25885 CC denotes and
T5138 25880-25882 , denotes ,
T5137 25879-25880 -RRB- denotes )
T5136 25872-25873 CD denotes 6
T5135 25870-25872 , denotes ,
T5134 25863-25870 NNS denotes females
T5133 25861-25862 CD denotes 6
T5132 25874-25879 NNS denotes males
T5131 25860-25861 -LRB- denotes (
T5130 25856-25857 HYPH denotes /
T5129 25853-25856 NN denotes DBA
T5128 25857-25859 NN denotes 2J
T5127 25850-25852 CD denotes 12
T5126 25848-25850 , denotes ,
T5125 25847-25848 -RRB- denotes )
T5124 25838-25839 CD denotes 7
T5123 25836-25838 , denotes ,
T5122 25831-25836 NNS denotes males
T5121 25829-25830 CD denotes 9
T5120 25827-25828 : denotes ;
T5119 25825-25827 NN denotes B6
T5118 25840-25847 NNS denotes females
T5117 25824-25825 -LRB- denotes (
T5116 25820-25821 HYPH denotes /
T5115 25815-25820 NN denotes C57BL
T5114 25821-25823 NN denotes 6J
T5113 25812-25814 CD denotes 16
T5112 25810-25812 : denotes :
T5111 25799-25810 NNS denotes experiments
T5110 25793-25798 DT denotes these
T5109 25790-25792 IN denotes in
T5108 25770-25782 RB denotes behaviorally
T5107 25765-25769 VBD denotes were
T5106 25753-25759 JJ denotes female
T5105 25749-25752 CC denotes and
T5104 25744-25748 JJ denotes male
T5103 25738-25743 JJ denotes adult
T5102 25760-25764 NNS denotes mice
T5101 25734-25737 CD denotes 188
T5100 25731-25733 IN denotes of
T5099 25783-25789 VBN denotes tested
T5098 25725-25730 NN denotes total
T5097 25723-25724 DT denotes A
T5096 25722-26049 sentence denotes A total of 188 adult male and female mice were behaviorally tested in these experiments: 16 C57BL/6J (B6; 9 males, 7 females), 12 DBA/2J (6 females, 6 males), and 90 BXD/Ty recombinant inbred mice (average = 5 / line; 64 males, 26 females) from 17 unique lines (1, 2, 5, 6, 11, 13, 14, 15, 20, 21, 24, 27, 29, 31, 32, 33, 34).
T5095 25713-25722 NNS denotes solutions
T5094 25709-25712 CC denotes and
T5093 25704-25708 NNS denotes Mice
T5548 27451-27456 NN denotes trial
T5547 27449-27450 DT denotes a
T5546 27440-27448 VB denotes initiate
T5545 27437-27439 TO denotes to
T5544 27435-27436 NN denotes s
T5543 27428-27430 IN denotes to
T5542 27431-27434 CD denotes 120
T5541 27425-27427 IN denotes up
T5540 27421-27424 VBD denotes had
T5539 27416-27420 NNS denotes mice
T5538 27412-27415 CC denotes and
T5537 27410-27412 , denotes ,
T5536 27409-27410 NN denotes s
T5535 27406-27408 CD denotes 10
T5534 27403-27405 IN denotes of
T5533 27382-27393 JJ denotes inter-trial
T5532 27394-27402 NN denotes interval
T5531 27379-27381 DT denotes an
T5530 27374-27378 IN denotes with
T5529 27367-27373 NN denotes length
T5528 27364-27366 IN denotes in
T5527 27362-27363 NN denotes s
T5526 27360-27361 CD denotes 5
T5525 27521-27527 VBD denotes closed
T5524 27355-27359 VBD denotes were
T5523 27348-27354 NNS denotes Trials
T5522 27347-27570 sentence denotes Trials were 5 s in length with an inter-trial interval of 10 s, and mice had up to 120 s to initiate a trial; if a trial was not initiated during this interval, the shutter closed for 10 s and the next trial was presented.
T5521 27346-27347 . denotes .
T5520 27341-27346 NN denotes mouse
T5519 27337-27340 IN denotes per
T5518 27333-27336 NN denotes day
T5517 27329-27332 IN denotes per
T5516 27316-27320 NN denotes test
T5515 27321-27328 NN denotes session
T5514 27312-27315 CD denotes one
T5513 27307-27311 IN denotes with
T5512 27305-27307 , denotes ,
T5511 27304-27305 CD denotes 4
T5510 27300-27303 CC denotes and
T5509 27298-27299 CD denotes 3
T5508 27289-27297 NNS denotes sessions
T5507 27286-27288 IN denotes in
T5506 27277-27285 VBD denotes occurred
T5505 27269-27276 NN denotes Testing
T5504 27268-27347 sentence denotes Testing occurred in sessions 3 and 4, with one test session per day per mouse.
T5503 27267-27268 . denotes .
T5502 27266-27267 -RRB- denotes )
T5501 27252-27257 NN denotes trial
T5500 27258-27266 NN denotes training
T5499 27251-27252 -LRB- denotes (
T5498 27245-27250 NN denotes water
T5497 27235-27244 JJ denotes distilled
T5496 27224-27234 VBG denotes containing
T5495 27216-27223 NNS denotes bottles
T5494 27211-27215 CD denotes four
T5493 27208-27210 IN denotes of
T5492 27204-27207 CD denotes one
T5491 27201-27203 IN denotes to
T5490 27189-27195 JJ denotes single
T5489 27196-27200 NN denotes lick
T5488 27187-27188 DT denotes a
T5487 27182-27186 IN denotes with
T5486 27173-27174 NN denotes s
T5485 27171-27172 CD denotes 5
T5484 27175-27181 NNS denotes trials
T5483 27160-27162 IN denotes to
T5482 27163-27170 CD denotes sixteen
T5481 27157-27159 IN denotes up
T5480 27142-27147 MD denotes could
T5479 27137-27141 NNS denotes mice
T5478 27135-27137 , denotes ,
T5477 27134-27135 CD denotes 2
T5476 27130-27133 NN denotes day
T5475 27148-27156 VB denotes initiate
T5474 27127-27129 IN denotes On
T5473 27126-27268 sentence denotes On day 2, mice could initiate up to sixteen 5 s trials with a single lick to one of four bottles containing distilled water (trial training).
T5472 27125-27126 . denotes .
T5471 27124-27125 -RRB- denotes )
T5470 27111-27115 NN denotes tube
T5469 27104-27110 NN denotes sipper
T5468 27116-27124 NN denotes training
T5467 27103-27104 -LRB- denotes (
T5466 27097-27102 NN denotes water
T5465 27087-27096 JJ denotes distilled
T5464 27084-27086 IN denotes of
T5463 27070-27076 JJ denotes single
T5462 27077-27083 NN denotes bottle
T5461 27068-27069 DT denotes a
T5460 27065-27067 IN denotes to
T5459 27058-27064 NN denotes access
T5458 27055-27057 IN denotes of
T5457 27044-27054 VBG denotes consisting
T5456 27030-27031 HYPH denotes -
T5455 27031-27037 NN denotes minute
T5454 27028-27030 CD denotes 20
T5453 27021-27027 JJ denotes single
T5452 27038-27043 NN denotes trial
T5451 27019-27020 DT denotes a
T5450 27009-27012 VBP denotes are
T5449 27004-27008 NNS denotes mice
T5448 26998-27003 NN denotes naïve
T5447 26996-26998 , denotes ,
T5446 26985-26996 NN denotes deprivation
T5445 26979-26984 NN denotes water
T5444 26976-26978 IN denotes of
T5443 26970-26975 NNS denotes hours
T5036 25692-25693 . denotes .
T5035 25685-25692 NNS denotes stimuli
T5034 25679-25684 JJ denotes toxic
T5033 25667-25678 RB denotes potentially
T5032 25664-25666 IN denotes of
T5031 25653-25657 JJ denotes wide
T5030 25658-25663 NN denotes array
T5029 25651-25652 DT denotes a
T5028 25648-25650 IN denotes to
T5027 25640-25647 VB denotes respond
T5026 25637-25639 TO denotes to
T5025 25625-25630 NN denotes taste
T5024 25614-25615 HYPH denotes -
T5023 25615-25624 JJ denotes sensitive
T5022 25608-25614 JJ denotes bitter
T5021 25606-25608 , denotes ,
T5020 25631-25636 NNS denotes cells
T5019 25595-25596 HYPH denotes -
T5018 25596-25606 VBG denotes expressing
T5017 25592-25595 NN denotes T2R
T5016 25589-25591 IN denotes of
T5015 25581-25588 NN denotes ability
T5014 25577-25580 DT denotes the
T5013 25568-25576 VB denotes preserve
T5012 25565-25567 TO denotes to
T5011 25556-25559 MD denotes may
T5010 25560-25564 VB denotes help
T4800 24657-24664 NN denotes century
T4799 24642-24645 DT denotes the
T4798 24639-24641 IN denotes in
T4797 24624-24631 JJ denotes similar
T4796 24632-24638 NN denotes origin
T4795 24622-24623 DT denotes a
T4794 24617-24621 VBP denotes have
T4793 24611-24616 WDT denotes which
T4792 24609-24611 , denotes ,
T4791 24602-24604 NN denotes D2
T4790 24598-24601 CC denotes and
T4789 24605-24609 NNS denotes mice
T4788 24595-24597 NN denotes B6
T4787 24666-24675 VBD denotes inherited
T4761 24452-24456 NN denotes fact
T4760 24448-24451 DT denotes the
T4759 24446-24448 , denotes ,
T4758 24539-24544 VBZ denotes makes
T4757 24439-24446 RB denotes However
T4756 24438-24574 sentence denotes However, the fact that these two mouse strains, members of the same species, are so closely related makes this explanation problematic.
T4755 24437-24438 . denotes .
T4754 24436-24437 -RRB- denotes ]
T4753 24433-24434 , denotes ,
T4752 24431-24433 CD denotes 43
T4751 24434-24436 CD denotes 44
T4750 24430-24431 -LRB- denotes [
T4749 24420-24429 NN denotes selection
T4748 24411-24419 JJ denotes positive
T4747 24408-24410 IN denotes of
T4746 24401-24407 NN denotes degree
T4745 24396-24400 DT denotes some
T4744 24393-24395 IN denotes to
T4743 24385-24392 JJ denotes subject
T4742 24374-24380 NNS denotes Tas2rs
T4741 24381-24384 VBP denotes are
T4740 24369-24373 IN denotes that
T4739 24353-24360 NNS denotes monkeys
T4738 24347-24352 NN denotes world
T4737 24343-24346 JJ denotes old
T4736 24339-24342 CC denotes and
T4735 24334-24338 NNS denotes apes
T4734 24328-24333 JJ denotes great
T4733 24326-24328 , denotes ,
T4732 24320-24326 NNS denotes humans
T4731 24317-24319 IN denotes in
T4730 24310-24316 NNS denotes Tas2rs
T4729 24307-24309 IN denotes of
T4728 24297-24306 NN denotes diversity
T4727 24288-24296 NN denotes sequence
T4726 24285-24287 IN denotes of
T4725 24361-24368 VBP denotes suggest
T4724 24276-24284 NN denotes Analysis
T4723 24275-24438 sentence denotes Analysis of sequence diversity of Tas2rs in humans, great apes and old world monkeys suggest that Tas2rs are subject to some degree of positive selection [43,44].
T4722 24274-24275 . denotes .
T4721 24265-24274 NN denotes selection
T4720 24256-24264 JJ denotes adaptive
T4719 24253-24255 IN denotes of
T4718 24242-24252 JJ denotes suggestive
T4717 24227-24238 NNS denotes orthologues
T4716 24219-24226 IN denotes between
T4715 24205-24218 NNS denotes substitutions
T4714 24191-24204 JJ denotes nonsynonymous
T4713 24188-24190 IN denotes of
T4712 24239-24241 VBZ denotes is
T4711 24174-24179 JJ denotes large
T4710 24180-24187 NNS denotes numbers
T4709 24169-24173 JJ denotes Such
T4708 24168-24275 sentence denotes Such large numbers of nonsynonymous substitutions between orthologues is suggestive of adaptive selection.
T4707 24167-24168 . denotes .
T4706 24149-24157 NN denotes receptor
T4705 24158-24167 NN denotes structure
T4704 24141-24148 JJ denotes overall
T4703 24138-24140 CC denotes or
T4702 24136-24138 , denotes ,
T4701 24128-24136 NN denotes proteins
T4700 24122-24127 JJ denotes other
T4699 24117-24121 IN denotes with
T4698 24104-24116 NNS denotes interactions
T4697 24102-24104 , denotes ,
T4696 24095-24102 NN denotes binding
T4695 24088-24094 NN denotes ligand
T4694 24077-24080 MD denotes may
T4693 24081-24087 VB denotes impact
T4692 24069-24076 NNS denotes changes
T4691 24063-24068 WDT denotes which
T4690 24053-24062 VB denotes determine
T4689 24050-24052 TO denotes to
T4688 24040-24049 JJ denotes necessary
T4687 24028-24035 NNS denotes stimuli
T4686 24021-24027 JJ denotes bitter
T4685 24018-24020 IN denotes of
T4684 24012-24017 NN denotes array
T4683 24009-24011 DT denotes an
T4682 24005-24008 CC denotes and
T4681 23992-23995 NN denotes T2R
T4680 23996-24004 NNS denotes variants
T4679 23986-23991 DT denotes these
T4678 23978-23985 IN denotes between
T4677 23964-23977 NNS denotes relationships
T4676 23954-23955 HYPH denotes -
T4675 23955-23963 NN denotes function
T4674 23945-23954 NN denotes structure
T4673 23942-23944 IN denotes of
T4672 24036-24039 VBP denotes are
T4671 23933-23941 NNS denotes analyses
T4670 23922-23932 JJ denotes systematic
T4669 23917-23921 RBR denotes More
T4668 23916-24168 sentence denotes More systematic analyses of structure-function relationships between these T2R variants and an array of bitter stimuli are necessary to determine which changes may impact ligand binding, interactions with other proteins, or overall receptor structure.
T4667 23915-23916 . denotes .
T4666 23914-23915 -RRB- denotes ]
T4665 23912-23914 CD denotes 23
T5226 26165-26167 IN denotes At
T4664 23911-23912 -LRB- denotes [
T4663 23906-23910 NNS denotes T2Rs
T4662 23901-23905 DT denotes some
T4661 23898-23900 IN denotes of
T4660 23880-23888 NN denotes response
T4659 23873-23879 NN denotes ligand
T4658 23889-23897 NNS denotes profiles
T4657 23869-23872 DT denotes the
T4656 23862-23868 VB denotes affect
T4655 23859-23861 TO denotes to
T4654 23844-23852 RB denotes recently
T4653 23839-23843 VBN denotes been
T4652 23834-23838 VBP denotes have
T4651 23853-23858 VBN denotes shown
T4650 23824-23827 CD denotes two
T4649 23828-23833 NNS denotes loops
T4648 23818-23823 DT denotes These
T4647 23817-23916 sentence denotes These two loops have been recently shown to affect the ligand response profiles of some T2Rs [23].
T4646 23816-23817 . denotes .
T4645 23807-23816 NNS denotes receptors
T4644 23803-23806 DT denotes the
T4643 23800-23802 IN denotes of
T4642 23780-23793 JJ denotes extracellular
T4641 23776-23779 CD denotes two
T4640 23770-23775 JJ denotes first
T4639 23794-23799 NNS denotes loops
T4638 23766-23769 DT denotes the
T4637 23752-23758 NNS denotes Tas2rs
T4636 23749-23751 NN denotes D2
T4635 23746-23748 IN denotes in
T4634 23736-23745 NNS denotes mutations
T4633 23727-23735 NN denotes missense
T4632 23724-23726 IN denotes of
T4631 23722-23723 NN denotes %
T4630 23720-23722 CD denotes 23
T4629 23718-23720 , denotes ,
T4628 23759-23765 VBP denotes affect
T4627 23705-23718 RB denotes Interestingly
T4626 23704-23817 sentence denotes Interestingly, 23% of missense mutations in D2 Tas2rs affect the first two extracellular loops of the receptors.
T4625 23703-23704 . denotes .
T4624 23683-23692 NN denotes signaling
T4623 23693-23703 NNS denotes mechanisms
T4622 23673-23674 HYPH denotes -
T4621 23674-23682 VBN denotes mediated
T4620 23665-23673 NN denotes receptor
T4619 23662-23664 CC denotes or
T4618 23649-23661 NNS denotes interactions
T4617 23642-23648 NN denotes ligand
T4616 23638-23641 IN denotes for
T4615 23628-23637 JJ denotes important
T4614 23620-23627 NNS denotes domains
T4613 23609-23612 RB denotes not
T4612 23606-23608 VBP denotes do
T4611 23597-23605 VBN denotes observed
T4610 23585-23596 NNS denotes differences
T4609 23581-23584 DT denotes the
T4608 23578-23580 IN denotes of
T4607 23573-23577 JJS denotes most
T4606 23565-23572 RB denotes perhaps
T4605 23613-23619 VB denotes affect
T4604 23560-23564 IN denotes that
T4603 23556-23559 CC denotes and
T4602 23554-23556 , denotes ,
T4601 23545-23554 NN denotes variation
T4600 23542-23544 IN denotes of
T4599 23533-23541 JJ denotes tolerant
T4598 23527-23532 RB denotes quite
T4597 23516-23522 NNS denotes Tas2rs
T4596 23523-23526 VBP denotes are
T4595 23511-23515 IN denotes that
T4594 23490-23502 NNS denotes observations
T4593 23484-23489 DT denotes these
T4592 23482-23484 , denotes ,
T4591 23474-23482 RB denotes together
T4590 23503-23510 VBP denotes suggest
T4589 23468-23473 VBN denotes Taken
T4588 23467-23704 sentence denotes Taken together, these observations suggest that Tas2rs are quite tolerant of variation, and that perhaps most of the differences observed do not affect domains important for ligand interactions or receptor-mediated signaling mechanisms.
T4587 23466-23467 . denotes .
T4586 23465-23466 -RRB- denotes ]
T4585 23463-23465 CD denotes 47
T4247 21649-21651 IN denotes if
T4246 21667-21669 VBZ denotes is
T4245 21647-21649 , denotes ,
T4244 21644-21647 CC denotes and
T4243 21638-21643 NN denotes taste
T4242 21630-21637 NN denotes quinine
T4241 21627-21629 IN denotes to
T4240 21617-21619 VBZ denotes is
T4239 21602-21612 JJ denotes suggestive
T4238 21613-21616 NN denotes QTL
T4237 21597-21601 DT denotes this
T4236 21620-21626 VBN denotes linked
T4235 21589-21596 IN denotes whether
T4234 21579-21588 VB denotes determine
T4233 21576-21578 TO denotes to
T4232 21564-21575 JJ denotes interesting
T4231 21556-21560 MD denotes will
T4230 21561-21563 VB denotes be
T4229 21553-21555 PRP denotes It
T4228 21552-21755 sentence denotes It will be interesting to determine whether this suggestive QTL is linked to quinine taste and, if so, whether it is specific for this single bitter stimulus or more broadly related to all bitter taste.
T4227 21551-21552 . denotes .
T4226 21550-21551 -RRB- denotes )
T4225 21534-21545 JJ denotes unpublished
T4224 21530-21533 PRP$ denotes our
T4223 21546-21550 NNS denotes data
T4222 21529-21530 -LRB- denotes (
T4221 21511-21519 NN denotes receptor
T4220 21520-21528 NNS denotes families
T4219 21505-21510 JJ denotes other
T4218 21502-21504 IN denotes of
T4217 21494-21501 NNS denotes members
T4216 21490-21493 CC denotes and
T4215 21482-21489 NNS denotes enzymes
T4214 21480-21482 , denotes ,
T4213 21472-21480 NNS denotes channels
T4212 21468-21471 NN denotes ion
T4211 21459-21467 VBG denotes encoding
T4210 21453-21458 NNS denotes genes
T4209 21450-21452 IN denotes of
T4208 21443-21449 NN denotes number
T4207 21441-21442 DT denotes a
T4206 21433-21440 VB denotes contain
T4205 21428-21432 VBZ denotes does
T4204 21424-21427 CC denotes but
T4203 21422-21424 , denotes ,
T4202 21411-21416 NN denotes Tas2r
T4201 21417-21422 NNS denotes genes
T4200 21407-21410 DT denotes any
T4199 21395-21398 RB denotes not
T4198 21390-21394 VBZ denotes does
T4197 21388-21389 CD denotes 8
T4196 21377-21387 NN denotes chromosome
T4195 21374-21376 IN denotes on
T4194 21359-21369 JJ denotes suggestive
T4193 21370-21373 NN denotes QTL
T4192 21357-21358 DT denotes a
T4191 21355-21357 , denotes ,
T4190 21399-21406 VB denotes contain
T4189 21351-21355 RB denotes Also
T4188 21350-21552 sentence denotes Also, a suggestive QTL on chromosome 8 does not contain any Tas2r genes, but does contain a number of genes encoding ion channels, enzymes and members of other receptor families (our unpublished data).
T4187 21349-21350 . denotes .
T4186 21348-21349 -RRB- denotes ]
T4185 21345-21346 , denotes ,
T4184 21343-21345 CD denotes 16
T4183 21346-21348 CD denotes 26
T4182 21342-21343 -LRB- denotes [
T4181 21336-21341 NN denotes taste
T4180 21328-21335 NN denotes quinine
T4179 21324-21327 IN denotes for
T4178 21308-21317 JJ denotes polygenic
T4177 21318-21323 NN denotes basis
T4176 21306-21307 DT denotes a
T4175 21301-21305 IN denotes with
T4174 21290-21300 JJ denotes consistent
T4173 21287-21289 VBZ denotes is
T4172 21275-21286 NN denotes observation
T4171 21270-21274 DT denotes This
T4170 21269-21350 sentence denotes This observation is consistent with a polygenic basis for quinine taste [16,26].
T4169 21268-21269 . denotes .
T4168 21267-21268 -RRB- denotes )
T4167 21264-21266 , denotes ,
T4166 21263-21264 CD denotes 1
T4165 21255-21262 NNS denotes Figures
T4164 21266-21267 CD denotes 7
T4163 21254-21255 -LRB- denotes (
T4162 21231-21243 JJ denotes intermediate
T4161 21226-21230 RBR denotes more
T4160 21244-21253 NN denotes phenotype
T4159 21224-21225 DT denotes a
T4158 21219-21223 IN denotes with
T4157 21207-21212 JJ denotes third
T4156 21213-21218 NN denotes group
T4155 21205-21206 DT denotes a
T4154 21201-21204 CC denotes and
T4153 21199-21201 , denotes ,
T4152 21197-21199 NN denotes D2
T4151 21194-21196 IN denotes of
T4150 21189-21193 DT denotes that
T4149 21186-21188 IN denotes to
T4148 21178-21185 JJ denotes similar
T4147 21164-21177 NNS denotes sensitivities
T4146 21159-21163 IN denotes with
T4145 21151-21158 NNS denotes strains
T4144 21146-21150 DT denotes some
T4143 21144-21146 , denotes ,
T4142 21142-21144 NN denotes B6
T4141 21139-21141 IN denotes of
T4140 21134-21138 DT denotes that
T4139 21131-21133 IN denotes to
T4138 21117-21130 NNS denotes sensitivities
T4137 21109-21116 JJ denotes similar
T4136 21102-21108 VBG denotes having
T4135 21094-21101 NNS denotes strains
T4134 21086-21093 JJ denotes several
T4133 21081-21085 IN denotes with
T4132 21079-21081 , denotes ,
T4131 21068-21079 NN denotes sensitivity
T4130 21060-21067 NN denotes quinine
T4129 21057-21059 IN denotes of
T4128 21051-21056 NN denotes range
T4127 21049-21050 DT denotes a
T4126 21030-21032 JJ denotes RI
T4125 21026-21029 NN denotes BXD
T4124 21033-21038 NNS denotes lines
T4123 21022-21025 DT denotes the
T4122 21020-21022 , denotes ,
T4121 21013-21020 NN denotes example
T4120 21039-21048 VBD denotes exhibited
T4119 21009-21012 IN denotes For
T4118 21008-21269 sentence denotes For example, the BXD RI lines exhibited a range of quinine sensitivity, with several strains having similar sensitivities to that of B6, some strains with sensitivities similar to that of D2, and a third group with a more intermediate phenotype (Figures 1, 7).
T4117 21007-21008 . denotes .
T4116 21005-21007 RB denotes so
T4115 20993-21004 RB denotes exclusively
T4114 20989-20992 RB denotes not
T4113 20983-20985 PRP denotes it
T4112 20981-20983 , denotes ,
T4990 25424-25431 IN denotes between
T4989 25407-25414 NN denotes protein
T4988 25415-25423 NN denotes sequence
T4987 25403-25406 NN denotes T2R
T4986 25400-25402 IN denotes in
T4985 25456-25464 VBZ denotes suggests
T4984 25379-25387 JJ denotes numerous
T4983 25388-25399 NNS denotes differences
T4982 25375-25378 DT denotes The
T4981 25374-25540 sentence denotes The numerous differences in T2R protein sequence between these two mouse strains suggests that T2Rs are broadly tuned receptors quite tolerant to sequence variation.
T4980 25373-25374 . denotes .
T4979 25362-25373 NN denotes sensitivity
T4978 25356-25361 NN denotes taste
T4977 25348-25355 NN denotes quinine
T4976 25343-25347 IN denotes with
T4975 25332-25342 VBZ denotes correlates
T4974 25327-25331 WDT denotes that
T4973 25310-25316 JJ denotes single
T4972 25317-25326 NN denotes haplotype
T4971 25308-25309 DT denotes a
T4970 25302-25307 VBZ denotes forms
T4969 25294-25301 NN denotes cluster
T4968 25289-25293 DT denotes this
T4967 25285-25288 CC denotes and
T4966 25283-25285 , denotes ,
T4965 25279-25283 NNS denotes mice
T4964 25276-25278 IN denotes of
T4963 25268-25275 NNS denotes strains
T4962 25261-25267 JJ denotes inbred
T4961 25254-25260 IN denotes across
T4960 25242-25253 JJ denotes polymorphic
T4959 25228-25229 CD denotes 6
T4958 25217-25227 NN denotes chromosome
T4957 25210-25216 JJ denotes distal
T4956 25230-25237 NN denotes cluster
T4955 25206-25209 DT denotes the
T4954 25203-25205 IN denotes in
T4953 25238-25241 VBP denotes are
T4952 25191-25196 NN denotes Tas2r
T4951 25197-25202 NNS denotes genes
T4950 25186-25190 JJS denotes Most
T4949 25185-25374 sentence denotes Most Tas2r genes in the distal chromosome 6 cluster are polymorphic across inbred strains of mice, and this cluster forms a single haplotype that correlates with quinine taste sensitivity.
T4948 25184-25185 . denotes .
T4947 25171-25174 NN denotes T2R
T4946 25166-25170 JJR denotes more
T4945 25163-25165 CC denotes or
T4944 25175-25184 NNS denotes receptors
T4943 25159-25162 CD denotes one
T4942 25156-25158 IN denotes on
T4941 25146-25155 JJ denotes dependent
T4940 25139-25145 RB denotes likely
T4939 25123-25135 NN denotes transduction
T4938 25117-25122 NN denotes taste
T4937 25109-25116 NN denotes quinine
T4936 25105-25108 IN denotes for
T4935 25089-25094 JJ denotes major
T4934 25095-25104 NN denotes mechanism
T4933 25085-25088 DT denotes the
T4932 25083-25085 , denotes ,
T4931 25136-25138 VBZ denotes is
T4930 25076-25083 RB denotes However
T4929 25075-25185 sentence denotes However, the major mechanism for quinine taste transduction is likely dependent on one or more T2R receptors.
T4928 25074-25075 . denotes .
T4927 25070-25074 NNS denotes mice
T4926 25067-25069 IN denotes in
T4925 25051-25060 JJ denotes polygenic
T4924 25061-25066 NN denotes trait
T4923 25049-25050 DT denotes a
T4922 25044-25046 , denotes ,
T4921 25032-25033 HYPH denotes -
T4920 25033-25039 NN denotes access
T4919 25027-25032 JJ denotes brief
T4918 25018-25026 JJ denotes specific
T4917 25012-25017 NN denotes taste
T4916 25040-25044 NN denotes test
T4915 25010-25011 DT denotes a
T4914 25007-25009 IN denotes by
T4913 24999-25006 VBN denotes assayed
T4912 24996-24998 IN denotes as
T4911 24994-24996 , denotes ,
T4910 24977-24986 NN denotes substance
T4909 24968-24969 HYPH denotes -
T4908 24969-24976 VBG denotes tasting
T4907 24962-24968 JJ denotes bitter
T4906 24987-24994 NN denotes quinine
T4905 24958-24961 DT denotes the
T4904 24955-24957 IN denotes to
T4903 24943-24954 NN denotes sensitivity
T4902 25046-25048 VBZ denotes is
T4901 24938-24942 IN denotes that
T4900 24927-24931 VBP denotes have
T4899 24924-24926 PRP denotes we
T4898 24922-24924 , denotes ,
T4897 24912-24922 NN denotes conclusion
T4896 24932-24937 VBN denotes found
T4895 24909-24911 IN denotes In
T4841 24895-24896 . denotes .
T4840 24890-24895 NN denotes issue
T4839 24885-24889 DT denotes this
T4838 24882-24884 IN denotes on
T4837 24876-24881 NN denotes light
T4836 24865-24870 MD denotes would
T4835 24863-24865 , denotes ,
T4834 24851-24857 JJ denotes inbred
T4833 24858-24863 NNS denotes lines
T4832 24845-24850 JJ denotes other
T4831 24842-24844 IN denotes in
T4830 24839-24841 CC denotes or
T4829 24837-24839 , denotes ,
T4828 24827-24837 NNS denotes subspecies
T4827 24824-24826 CC denotes or
T4826 24816-24823 NNS denotes species
T4825 24805-24809 JJ denotes wild
T4824 24810-24815 NN denotes mouse
T4823 24797-24804 JJ denotes several
T4822 24794-24796 IN denotes of
T4821 24784-24793 NNS denotes sequences
T4820 24778-24783 NN denotes Tas2r
T4819 24775-24777 IN denotes of
T4818 24871-24875 VB denotes shed
T4817 24758-24774 NN denotes Characterization
T4816 24757-24896 sentence denotes Characterization of Tas2r sequences of several wild mouse species or subspecies, or in other inbred lines, would shed light on this issue.
T4815 24756-24757 . denotes .
T4814 24746-24756 NN denotes inbreeding
T4813 24743-24745 IN denotes to
T4812 24737-24742 JJ denotes prior
T4811 24719-24724 NN denotes mouse
T4810 24725-24736 NNS denotes populations
T4809 24714-24718 JJ denotes wild
T4808 24711-24713 IN denotes in
T4807 24703-24710 JJ denotes present
T4806 24686-24691 NN denotes Tas2r
T4805 24692-24702 NNS denotes haplotypes
T4804 24676-24685 JJ denotes different
T4803 24664-24666 , denotes ,
T4802 24652-24656 JJ denotes 20th
T4801 24646-24651 JJ denotes early
T4111 20971-20972 HYPH denotes -
T4110 20968-20971 NN denotes T2R
T4109 20972-20981 JJ denotes dependent
T4108 20960-20967 RB denotes largely
T4107 20951-20956 NN denotes taste
T4106 20943-20950 NN denotes quinine
T4105 20957-20959 VBZ denotes is
T4104 20938-20942 IN denotes that
T4103 20986-20988 VBZ denotes is
T4102 20923-20927 NNS denotes data
T4101 20919-20922 PRP$ denotes our
T4100 20928-20937 VBZ denotes indicates
T4099 20913-20918 IN denotes While
T4098 20912-21008 sentence denotes While our data indicates that quinine taste is largely T2R-dependent, it is not exclusively so.
T4097 20911-20912 . denotes .
T4096 20910-20911 -RRB- denotes ]
T4095 20908-20910 CD denotes 36
T4094 20907-20908 SYM denotes -
T4093 20905-20907 CD denotes 34
T4092 20904-20905 -LRB- denotes [
T4091 20898-20903 NNS denotes cells
T4090 20889-20897 NN denotes receptor
T4089 20883-20888 NN denotes taste
T4088 20880-20882 IN denotes in
T4087 20869-20870 SYM denotes +
T4086 20871-20879 NNS denotes channels
T4085 20868-20869 NN denotes K
T4084 20862-20867 VB denotes block
T4083 20858-20861 MD denotes can
T4082 20855-20857 CC denotes or
T4081 20853-20855 , denotes ,
T4080 20841-20853 NNS denotes conductances
T4079 20832-20840 JJ denotes cationic
T4078 20829-20831 CC denotes or
T4077 20820-20828 NN denotes proteins
T4076 20818-20819 NN denotes G
T4075 20800-20808 RB denotes directly
T4074 20796-20799 MD denotes can
T4073 20788-20795 NN denotes quinine
T4072 20809-20817 VB denotes activate
T4071 20783-20787 IN denotes that
T4070 20768-20772 VBP denotes have
T4069 20746-20759 JJ denotes physiological
T4068 20760-20767 NNS denotes studies
T4067 20738-20745 JJ denotes several
T4066 20736-20738 , denotes ,
T4065 20773-20782 VBN denotes suggested
T4064 20729-20736 RB denotes However
T4063 20728-20912 sentence denotes However, several physiological studies have suggested that quinine can directly activate G proteins or cationic conductances, or can block K+ channels in taste receptor cells [34-36].
T4062 20727-20728 . denotes .
T4061 20726-20727 -RRB- denotes ]
T4060 20724-20726 CD denotes 23
T4059 20723-20724 -LRB- denotes [
T4058 20715-20722 NN denotes quinine
T4057 20712-20714 IN denotes of
T4056 20694-20704 JJ denotes lipophilic
T4055 20705-20711 NN denotes nature
T4054 20690-20693 DT denotes the
T4053 20687-20689 IN denotes to
T4052 20683-20686 IN denotes due
T4051 20676-20682 RB denotes likely
T4050 20674-20676 , denotes ,
T4049 20662-20674 NNS denotes preparations
T4048 20653-20661 NN denotes membrane
T4047 20650-20652 CC denotes or
T4046 20644-20649 NNS denotes cells
T4045 20631-20643 JJ denotes heterologous
T4044 20628-20630 IN denotes in
T4043 20618-20627 NNS denotes receptors
T4042 20612-20617 DT denotes these
T4041 20609-20611 IN denotes of
T4040 20602-20608 NNS denotes assays
T4039 20591-20601 JJ denotes functional
T4038 20586-20590 IN denotes from
T4037 20581-20585 NNS denotes T2Rs
T4036 20578-20580 IN denotes of
T4035 20567-20577 NN denotes activation
T4034 20559-20566 NN denotes quinine
T4033 20555-20558 IN denotes for
T4032 20546-20554 NN denotes evidence
T3992 20364-20367 IN denotes due
T3991 20362-20363 -RRB- denotes )
T3990 20361-20362 AFX denotes s
T3989 20360-20361 -LRB- denotes (
T3988 20350-20355 NN denotes trait
T3987 20337-20349 JJ denotes quantitative
T3986 20332-20336 NN denotes QHCl
T3985 20356-20360 NN denotes gene
T3984 20328-20331 DT denotes the
T3983 20324-20327 IN denotes for
T3982 20306-20312 JJ denotes likely
T3981 20301-20305 RBS denotes most
T3980 20313-20323 NNS denotes candidates
T3979 20297-20300 DT denotes the
T3978 20293-20296 VBP denotes are
T3977 20286-20292 NNS denotes Tas2rs
T3976 20285-20523 sentence denotes Tas2rs are the most likely candidates for the QHCl quantitative trait gene(s) due to: (1) their expression in taste receptor cells and (2) genetic and functional evidence linking them to the detection of a number of bitter taste stimuli.
T3975 20284-20285 . denotes .
T3974 20283-20284 -RRB- denotes ]
T3973 20281-20283 CD denotes 48
T3972 20280-20281 -LRB- denotes [
T3971 20274-20279 NN denotes taste
T3970 20267-20273 JJ denotes bitter
T3969 20264-20266 IN denotes in
T3968 20252-20258 JJ denotes direct
T3967 20259-20263 NN denotes role
T3966 20249-20251 DT denotes no
T3965 20244-20248 VB denotes play
T3964 20241-20243 TO denotes to
T3963 20225-20233 NN denotes proteins
T3962 20219-20224 DT denotes these
T3961 20217-20218 : denotes ;
T3960 20213-20217 NN denotes Prh1
T3959 20209-20212 CC denotes and
T3958 20204-20208 NN denotes Prp2
T3957 20202-20204 , denotes ,
T3956 20185-20193 JJ denotes salivary
T3955 20194-20202 NN denotes proteins
T3954 20179-20180 HYPH denotes -
T3953 20180-20184 JJ denotes rich
T3952 20172-20179 NN denotes proline
T3951 20165-20171 VBP denotes encode
T3950 20160-20164 WDT denotes that
T3949 20154-20159 NNS denotes genes
T3948 20150-20153 CD denotes two
T3947 20140-20149 VBG denotes including
T3946 20138-20140 , denotes ,
T3945 20130-20138 NN denotes interval
T3944 20125-20129 DT denotes this
T3943 20118-20124 IN denotes within
T3942 20234-20240 VBP denotes appear
T3941 20109-20113 RB denotes also
T3940 20114-20117 VBP denotes lie
T3939 20097-20102 JJ denotes other
T3938 20103-20108 NNS denotes genes
T3937 20088-20093 RBS denotes least
T3936 20094-20096 CD denotes 60
T3935 20085-20087 RB denotes At
T3934 20084-20285 sentence denotes At least 60 other genes also lie within this interval, including two genes that encode proline-rich salivary proteins, Prp2 and Prh1; these proteins appear to play no direct role in bitter taste [48].
T3933 20083-20084 . denotes .
T3932 20072-20077 NN denotes Tas2r
T3931 20078-20083 NNS denotes genes
T3930 20069-20071 CD denotes 24
T3929 20060-20068 VBZ denotes contains
T3928 20055-20059 WDT denotes that
T3927 20053-20054 CD denotes 6
T3926 20042-20052 NN denotes chromosome
T3925 20035-20041 JJ denotes distal
T3924 20032-20034 IN denotes on
T3923 20022-20024 NN denotes Mb
T3922 20020-20021 CD denotes 5
T3921 20018-20019 SYM denotes <
T3920 20025-20031 NN denotes region
T3919 20016-20017 DT denotes a
T3918 20013-20015 IN denotes to
T3917 20003-20008 NN denotes taste
T3916 19995-20002 NN denotes quinine
T3915 20009-20012 NN denotes QTL
T3914 19991-19994 DT denotes the
T3913 19975-19979 VBP denotes have
T3912 19972-19974 PRP denotes we
T3911 19970-19972 , denotes ,
T3910 19951-19962 JJ denotes chromosomal
T3909 19963-19970 NNS denotes markers
T3908 19947-19950 CD denotes 762
T3907 19943-19946 CC denotes and
T3906 19934-19936 JJ denotes RI
T3905 19937-19942 NNS denotes lines
T3904 19931-19933 CD denotes 17
T3903 19980-19990 VBN denotes restricted
T3902 19925-19930 VBG denotes Using
T3901 19924-20084 sentence denotes Using 17 RI lines and 762 chromosomal markers, we have restricted the quinine taste QTL to a < 5 Mb region on distal chromosome 6 that contains 24 Tas2r genes.
T3900 19923-19924 . denotes .
T3899 19922-19923 -RRB- denotes ]
T3898 19920-19922 CD denotes 29
T3897 19919-19920 -LRB- denotes [
T3896 19910-19918 NN denotes toxicity
T3895 19907-19909 IN denotes as
T3894 19902-19906 JJ denotes such
T3893 19900-19902 , denotes ,
T3892 19895-19900 NN denotes taste
T3891 19892-19894 IN denotes of
T3890 19880-19891 JJ denotes independent
T3889 19872-19879 NNS denotes factors
T3888 19869-19871 IN denotes on
T3887 19859-19868 JJ denotes dependent
T3886 19852-19855 MD denotes can
T3885 19844-19851 NNS denotes stimuli
T3884 19835-19836 HYPH denotes -
T3883 19836-19843 VBG denotes tasting
T3882 19829-19835 JJ denotes bitter
T3881 19826-19828 IN denotes of
T3880 19814-19825 NN denotes consumption
T3879 19810-19813 DT denotes the
T3878 19856-19858 VB denotes be
T3877 19807-19809 IN denotes as
T3876 19805-19807 , denotes ,
T3875 19784-19793 JJ denotes important
T3874 19794-19805 NN denotes distinction
T3873 19781-19783 DT denotes an
T3872 19778-19780 VBZ denotes is
T3871 19773-19777 DT denotes This
T3870 19772-19924 sentence denotes This is an important distinction, as the consumption of bitter-tasting stimuli can be dependent on factors independent of taste, such as toxicity [29].
T3869 19771-19772 . denotes .
T3868 19763-19771 NN denotes aversion
T3867 19755-19762 NN denotes quinine
T3866 19744-19754 VBG denotes regulating
T3865 19741-19743 IN denotes in
T3864 19728-19733 JJ denotes major
T3863 19734-19740 NN denotes factor
T3862 19724-19727 DT denotes the
T3861 19715-19720 NN denotes taste
T3860 19721-19723 VBZ denotes is
T3859 19710-19714 IN denotes that
T3858 19699-19709 VBG denotes indicating
T3857 19697-19699 , denotes ,
T4437 22691-22692 -RRB- denotes )
T4436 22688-22691 NN denotes PTC
T4435 22687-22688 -LRB- denotes (
T4434 22699-22710 NN denotes sensitivity
T4433 22667-22686 NN denotes phenylthiocarbamide
T4432 22664-22666 IN denotes of
T4431 22655-22663 NN denotes variance
T4430 22652-22654 IN denotes of
T4429 22643-22651 NN denotes majority
T4428 22639-22642 DT denotes the
T4427 22635-22638 IN denotes for
T4426 22623-22634 JJ denotes responsible
T4425 22617-22622 NN denotes Tas2r
T4424 22613-22616 DT denotes the
T4423 22610-22612 IN denotes of
T4422 22595-22609 NN denotes identification
T4421 22591-22594 DT denotes the
T4420 22576-22580 RB denotes also
T4419 22581-22590 VBD denotes permitted
T4418 22568-22575 NN denotes cloning
T4417 22557-22567 JJ denotes Positional
T4416 22556-22726 sentence denotes Positional cloning also permitted the identification of the Tas2r responsible for the majority of variance of phenylthiocarbamide (PTC) taste sensitivity in humans [18].
T4415 22555-22556 . denotes .
T4414 22554-22555 -RRB- denotes ]
T4413 22552-22554 CD denotes 42
T4412 22551-22552 -LRB- denotes [
T4411 22539-22544 NN denotes umami
T4410 22535-22538 CC denotes and
T4409 22545-22550 NN denotes taste
T4408 22529-22534 JJ denotes sweet
T4407 22525-22528 IN denotes for
T4406 22515-22524 JJ denotes important
T4405 22506-22514 NN denotes receptor
T4404 22504-22505 DT denotes a
T4403 22496-22503 VBZ denotes encodes
T4402 22491-22495 WDT denotes that
T4401 22479-22485 NN denotes Tas1r3
T4400 22486-22490 NN denotes gene
T4399 22475-22478 DT denotes the
T4398 22472-22474 IN denotes as
T4397 22467-22471 JJ denotes such
T4396 22465-22467 , denotes ,
T4395 22457-22465 NN denotes function
T4394 22451-22456 NN denotes taste
T4393 22448-22450 IN denotes in
T4392 22439-22447 VBN denotes involved
T4391 22433-22438 NNS denotes genes
T4390 22421-22432 VBG denotes identifying
T4389 22417-22420 IN denotes for
T4388 22406-22416 JJ denotes invaluable
T4387 22396-22400 VBP denotes have
T4386 22401-22405 VBN denotes been
T4385 22377-22384 JJ denotes genetic
T4384 22385-22395 NNS denotes approaches
T4383 22366-22376 JJ denotes Behavioral
T4382 22365-22556 sentence denotes Behavioral genetic approaches have been invaluable for identifying genes involved in taste function, such as the Tas1r3 gene that encodes a receptor important for sweet and umami taste [42].
T4381 22364-22365 . denotes .
T4380 22363-22364 -RRB- denotes )
T4379 22354-22357 RB denotes not
T4378 22349-22353 NNS denotes data
T4377 22358-22363 VBN denotes shown
T4376 22348-22349 -LRB- denotes (
T4375 22334-22339 NN denotes Tas2r
T4374 22340-22347 NN denotes cluster
T4373 22330-22333 DT denotes the
T4372 22323-22329 IN denotes within
T4371 22308-22322 NNS denotes recombinations
T4370 22305-22307 DT denotes no
T4369 22289-22294 RB denotes again
T4368 22280-22282 JJ denotes RI
T4367 22283-22288 NNS denotes lines
T4366 22274-22279 DT denotes these
T4365 22271-22273 IN denotes in
T4364 22264-22270 NNS denotes Tas2rs
T4363 22260-22263 DT denotes the
T4362 22257-22259 IN denotes of
T4361 22242-22247 JJ denotes small
T4360 22248-22256 NN denotes sampling
T4359 22240-22241 DT denotes a
T4358 22238-22239 , denotes ;
T4357 22231-22238 NN denotes D6Mit13
T4356 22224-22230 IN denotes around
T4355 22209-22223 NNS denotes recombinations
T4354 22200-22208 VBN denotes reported
T4353 22195-22199 IN denotes with
T4352 22187-22190 NN denotes BXA
T4351 22183-22186 CC denotes and
T4350 22191-22194 NNS denotes RIs
T4349 22179-22182 NN denotes AXB
T4348 22176-22178 IN denotes of
T4347 22170-22175 NNS denotes lines
T4346 22166-22169 CD denotes six
T4345 22295-22304 VBD denotes indicated
T4344 22154-22156 PRP denotes we
T4343 22152-22154 , denotes ,
T4342 22145-22152 NN denotes example
T4341 22157-22165 VBD denotes examined
T4340 22141-22144 IN denotes For
T4339 22140-22365 sentence denotes For example, we examined six lines of AXB and BXA RIs with reported recombinations around D6Mit13; a small sampling of the Tas2rs in these RI lines again indicated no recombinations within the Tas2r cluster (data not shown).
T4338 22139-22140 . denotes .
T4337 22134-22139 NN denotes taste
T4336 22126-22133 NN denotes quinine
T4335 22123-22125 IN denotes in
T4334 22114-22122 VBN denotes involved
T4333 22107-22113 NNS denotes Tas2rs
T4332 22103-22106 JJ denotes few
T4331 22101-22102 DT denotes a
T4330 22098-22100 CC denotes or
T4329 22094-22097 CD denotes one
T4328 22091-22093 IN denotes of
T4327 22076-22090 NN denotes identification
T4326 22072-22075 DT denotes the
T4325 22065-22071 VB denotes permit
T4324 22062-22064 TO denotes to
T4323 22053-22061 JJ denotes unlikely
T4322 22040-22042 DT denotes an
T4321 22043-22049 NN denotes effort
T4320 22035-22039 PDT denotes such
T4319 22030-22034 NN denotes case
T4318 22025-22029 DT denotes this
T4317 22022-22024 IN denotes in
T4316 22020-22022 , denotes ,
T4315 22007-22010 NN denotes QTL
T4314 22011-22020 NNS denotes intervals
T4313 21999-22006 JJR denotes smaller
T4312 21996-21998 IN denotes of
T4311 21985-21995 NN denotes definition
T4310 21981-21984 DT denotes the
T4309 22050-22052 VBZ denotes is
T4308 21964-21969 MD denotes would
T4307 21959-21963 PRP denotes them
T4306 21948-21958 VBG denotes genotyping
T4305 21944-21947 IN denotes for
T4304 21939-21943 VBN denotes used
T4303 21931-21938 NNS denotes markers
T4302 21928-21930 IN denotes of
T4301 21921-21927 NN denotes number
T4300 21917-21920 DT denotes the
T4299 21914-21916 CC denotes or
T4298 21905-21907 JJ denotes RI
T4297 21908-21913 NNS denotes lines
T4296 21901-21904 NN denotes BXD
T4295 21898-21900 IN denotes of
T4294 21891-21897 NN denotes number
T4293 21887-21890 DT denotes the
T4292 21876-21886 VBG denotes increasing
T4291 21970-21980 VB denotes facilitate
T4290 21870-21875 IN denotes While
T4289 21869-22140 sentence denotes While increasing the number of BXD RI lines or the number of markers used for genotyping them would facilitate the definition of smaller QTL intervals, in this case such an effort is unlikely to permit the identification of one or a few Tas2rs involved in quinine taste.
T4288 21868-21869 . denotes .
T4287 21855-21860 NN denotes Tas2r
T4286 21853-21854 CD denotes 6
T4285 21842-21852 NN denotes chromosome
T4284 21861-21868 NN denotes cluster
T4283 21838-21841 DT denotes the
T4282 21831-21837 IN denotes within
T4281 21811-21824 NN denotes recombination
T4280 21802-21810 JJ denotes apparent
T4279 21825-21830 NN denotes event
T4278 21799-21801 DT denotes no
T4277 21789-21794 EX denotes there
T4276 21787-21789 , denotes ,
T4275 21779-21787 VBN denotes examined
T4274 21770-21772 JJ denotes RI
T4273 21766-21769 NN denotes BXD
T4272 21763-21765 CD denotes 29
T4271 21773-21778 NNS denotes lines
T4270 21759-21762 DT denotes the
T4269 21795-21798 VBD denotes was
T4268 21756-21758 IN denotes Of
T4267 21755-21869 sentence denotes Of the 29 BXD RI lines examined, there was no apparent recombination event within the chromosome 6 Tas2r cluster.
T4266 21754-21755 . denotes .
T4265 21742-21748 JJ denotes bitter
T4264 21749-21754 NN denotes taste
T4263 21738-21741 DT denotes all
T4262 21735-21737 IN denotes to
T4261 21727-21734 JJ denotes related
T4260 21719-21726 RB denotes broadly
T4259 21714-21718 RBR denotes more
T4258 21711-21713 CC denotes or
T4257 21695-21701 JJ denotes bitter
T4256 21688-21694 JJ denotes single
T4255 21702-21710 NN denotes stimulus
T4254 21683-21687 DT denotes this
T4253 21679-21682 IN denotes for
T4252 21670-21678 JJ denotes specific
T4251 21664-21666 PRP denotes it
T4250 21656-21663 IN denotes whether
T4249 21654-21656 , denotes ,
T4248 21652-21654 RB denotes so
T3856 19696-19697 -RRB- denotes ]
T3855 19693-19694 , denotes ,
T3854 19691-19693 CD denotes 16
T3853 19694-19696 CD denotes 28
T3852 19690-19691 -LRB- denotes [
T3851 19686-19689 NN denotes Qui
T3850 19684-19686 , denotes ,
T3849 19678-19684 NN denotes intake
T3848 19670-19677 NN denotes quinine
T3847 19666-19669 IN denotes for
T3846 19651-19661 VBN denotes identified
T3845 19640-19650 RB denotes previously
T3844 19662-19665 NN denotes QTL
T3843 19638-19639 DT denotes a
T3842 19635-19637 IN denotes as
T3841 19614-19625 JJ denotes chromosomal
T3840 19609-19613 JJ denotes same
T3839 19626-19634 NN denotes position
T3838 19605-19608 DT denotes the
T3837 19602-19604 IN denotes to
T3836 19597-19601 VBZ denotes maps
T3835 19593-19596 NN denotes QTL
T3834 19588-19592 DT denotes This
T3833 19587-19772 sentence denotes This QTL maps to the same chromosomal position as a previously identified QTL for quinine intake, Qui [16,28], indicating that taste is the major factor in regulating quinine aversion.
T3832 19586-19587 . denotes .
T3831 19579-19581 NN denotes D2
T3830 19575-19578 CC denotes and
T3829 19582-19586 NNS denotes mice
T3828 19572-19574 NN denotes B6
T3827 19564-19571 IN denotes between
T3826 19552-19563 NN denotes sensitivity
T3825 19546-19551 NN denotes taste
T3824 19541-19545 NN denotes QHCL
T3823 19538-19540 IN denotes in
T3822 19528-19537 NN denotes variation
T3821 19524-19527 DT denotes the
T3820 19521-19523 IN denotes of
T3819 19516-19520 JJS denotes most
T3818 19512-19515 IN denotes for
T3817 19501-19502 CD denotes 6
T3816 19490-19500 NN denotes chromosome
T3815 19483-19489 JJ denotes distal
T3814 19480-19482 IN denotes on
T3813 19469-19475 JJ denotes single
T3812 19476-19479 NN denotes QTL
T3811 19467-19468 DT denotes a
T3810 19503-19511 VBZ denotes accounts
T3809 19462-19466 IN denotes that
T3808 19451-19455 VBP denotes have
T3807 19456-19461 VBN denotes found
T3806 19448-19450 PRP denotes We
T3805 19447-19587 sentence denotes We have found that a single QTL on distal chromosome 6 accounts for most of the variation in QHCL taste sensitivity between B6 and D2 mice.
T3804 19446-19447 . denotes .
T3803 19429-19435 RB denotes poorly
T3802 19423-19428 RB denotes still
T3801 19420-19422 VBZ denotes is
T3800 19405-19412 JJ denotes nervous
T3799 19397-19404 JJ denotes central
T3798 19413-19419 NN denotes system
T3797 19393-19396 DT denotes the
T3796 19390-19392 IN denotes to
T3795 19380-19389 NN denotes signaling
T3794 19376-19379 CC denotes and
T3793 19365-19375 NN denotes activation
T3792 19356-19364 JJ denotes cellular
T3791 19353-19355 IN denotes to
T3790 19333-19341 NN denotes receptor
T3789 19342-19347 NNS denotes cells
T3788 19327-19332 NN denotes taste
T3787 19322-19326 IN denotes with
T3786 19314-19321 NNS denotes stimuli
T3785 19307-19313 JJ denotes bitter
T3784 19304-19306 IN denotes of
T3783 19291-19303 NNS denotes interactions
T3782 19348-19352 VBP denotes lead
T3781 19287-19290 WRB denotes how
T3780 19285-19287 , denotes ,
T3779 19278-19285 NNS denotes stimuli
T3778 19271-19277 JJ denotes bitter
T3777 19268-19270 IN denotes of
T3773 19436-19446 VBN denotes understood
T3772 19232-19236 VBN denotes been
T3771 19227-19231 VBP denotes have
T3770 19218-19226 NNS denotes channels
T3769 19214-19217 CC denotes and
T3768 19206-19213 NNS denotes enzymes
T3767 19204-19206 , denotes ,
T3766 19195-19204 NNS denotes receptors
T3765 19186-19194 JJ denotes specific
T3764 19237-19247 VBN denotes implicated
T3763 19177-19185 IN denotes Although
T3762 19176-19447 sentence denotes Although specific receptors, enzymes and channels have been implicated in the transduction of bitter stimuli, how interactions of bitter stimuli with taste receptor cells lead to cellular activation and signaling to the central nervous system is still poorly understood.
T3761 19175-19176 . denotes .
T3760 19174-19175 -RRB- denotes ]
T3759 19172-19174 CD denotes 41
T3758 19171-19172 -LRB- denotes [
T3757 19151-19152 HYPH denotes -
T3756 19152-19159 VBG denotes tasting
T3755 19145-19151 JJ denotes bitter
T3754 19160-19170 NNS denotes substances
T3753 19136-19137 HYPH denotes -
T3752 19137-19144 JJ denotes diverse
T3751 19126-19136 RB denotes chemically
T3750 19123-19125 IN denotes of
T3749 19113-19122 NNS denotes thousands
T3748 19106-19112 VB denotes detect
T3747 19103-19105 TO denotes to
T3746 19092-19094 VBZ denotes is
T3745 19084-19091 NNS denotes mammals
T3744 19081-19083 IN denotes of
T3743 19095-19102 VBN denotes thought
T3742 19064-19073 JJ denotes gustatory
T3741 19074-19080 NN denotes system
T3740 19060-19063 DT denotes The
T4994 25442-25447 NN denotes mouse
T4993 25438-25441 CD denotes two
T4992 25448-25455 NNS denotes strains
T4991 25432-25437 DT denotes these
T4584 23462-23463 -LRB- denotes [
T4583 23448-23461 NN denotes cyclohexamide
T4582 23445-23447 CC denotes or
T4581 23442-23444 NN denotes DB
T4580 23439-23441 IN denotes as
T4579 23434-23438 JJ denotes such
T4578 23424-23433 NNS denotes compounds
T4577 23417-23423 JJ denotes bitter
T4576 23414-23416 IN denotes to
T4575 23398-23403 NN denotes taste
T4574 23404-23413 NNS denotes responses
T4573 23390-23397 JJ denotes similar
T4572 23374-23381 NNS denotes strains
T4571 23368-23373 DT denotes these
T4570 23361-23367 IN denotes though
T4569 23382-23389 VBP denotes exhibit
T4568 23356-23360 RB denotes even
T4567 23348-23350 NN denotes D2
T4566 23344-23347 CC denotes and
T4565 23351-23355 NNS denotes mice
T4564 23341-23343 NN denotes B6
T4563 23338-23340 IN denotes in
T4562 23329-23337 NN denotes proteins
T4561 23321-23328 JJ denotes variant
T4560 23305-23313 VBN denotes examined
T4559 23295-23297 CD denotes 24
T4558 23298-23304 NNS denotes Tas2rs
T4557 23291-23294 DT denotes the
T4556 23288-23290 IN denotes of
T4555 23285-23287 CD denotes 22
T4554 23314-23320 VBP denotes encode
T4553 23280-23284 IN denotes that
T4552 23271-23279 JJ denotes puzzling
T4551 23262-23270 RB denotes somewhat
T4550 23259-23261 VBZ denotes is
T4549 23256-23258 PRP denotes It
T4548 23255-23467 sentence denotes It is somewhat puzzling that 22 of the 24 Tas2rs examined encode variant proteins in B6 and D2 mice even though these strains exhibit similar taste responses to bitter compounds such as DB or cyclohexamide [47].
T4547 23254-23255 . denotes .
T4546 23253-23254 -RRB- denotes )
T4545 23244-23247 RB denotes not
T4544 23239-23243 NNS denotes data
T4543 23248-23253 VBN denotes shown
T4542 23238-23239 -LRB- denotes (
T4541 23233-23237 NNS denotes loci
T4540 23227-23232 DT denotes these
T4539 23224-23226 IN denotes at
T4538 23211-23217 NNS denotes Tas2rs
T4537 23207-23210 VBP denotes are
T4536 23202-23206 NN denotes case
T4535 23194-23201 DT denotes neither
T4534 23191-23193 IN denotes in
T4533 23189-23190 : denotes ;
T4532 23188-23189 -RRB- denotes )
T4531 23187-23188 CD denotes 2
T4530 23180-23186 NN denotes Figure
T4529 23179-23180 -LRB- denotes (
T4528 23177-23178 CD denotes 8
T4527 23166-23176 NN denotes chromosome
T4526 23163-23165 IN denotes on
T4525 23157-23162 NN denotes taste
T4524 23149-23156 NN denotes quinine
T4523 23145-23148 IN denotes for
T4522 23130-23140 JJ denotes suggestive
T4521 23141-23144 NN denotes QTL
T4520 23128-23129 DT denotes a
T4519 23120-23127 VBP denotes observe
T4518 23117-23119 PRP denotes we
T4517 23113-23116 CC denotes and
T4516 23111-23113 , denotes ,
T4515 23110-23111 -RRB- denotes ]
T4514 23108-23110 CD denotes 16
T4513 23107-23108 -LRB- denotes [
T4512 23105-23106 CD denotes 7
T4511 23094-23104 NN denotes chromosome
T4510 23091-23093 IN denotes on
T4509 23218-23223 VBN denotes found
T4508 23076-23080 VBN denotes been
T4507 23072-23075 VBZ denotes has
T4506 23062-23071 NN denotes avoidance
T4505 23057-23061 NN denotes PROP
T4504 23053-23056 IN denotes for
T4503 23049-23052 NN denotes QTL
T4502 23047-23048 DT denotes a
T4501 23045-23047 , denotes ,
T4500 23038-23045 NN denotes example
T4499 23081-23090 VBN denotes suggested
T4498 23034-23037 IN denotes For
T4497 23033-23255 sentence denotes For example, a QTL for PROP avoidance has been suggested on chromosome 7 [16], and we observe a suggestive QTL for quinine taste on chromosome 8 (Figure 2); in neither case are Tas2rs found at these loci (data not shown).
T4496 23032-23033 . denotes .
T4495 23009-23021 NN denotes transduction
T4494 23022-23032 NNS denotes mechanisms
T4493 22996-22997 HYPH denotes -
T4492 22997-23008 JJ denotes independent
T4491 22993-22996 NN denotes T2R
T4490 22990-22992 IN denotes of
T4489 22979-22989 NNS denotes components
T4488 22976-22978 CC denotes or
T4487 22966-22975 NNS denotes molecules
T4486 22956-22965 NN denotes signaling
T4485 22945-22955 JJ denotes downstream
T4484 22936-22944 VBG denotes encoding
T4483 22930-22935 NNS denotes genes
T4482 22918-22929 VBG denotes identifying
T4481 22914-22917 IN denotes for
T4480 22907-22913 JJ denotes useful
T4479 22902-22906 RBR denotes more
T4478 22895-22898 MD denotes may
T4477 22876-22883 JJ denotes genetic
T4476 22884-22894 NNS denotes approaches
T4475 22865-22875 JJ denotes behavioral
T4474 22863-22865 , denotes ,
T4473 22858-22863 NN denotes taste
T4472 22851-22857 JJ denotes bitter
T4471 22899-22901 VB denotes be
T4470 22847-22850 IN denotes For
T4469 22846-23033 sentence denotes For bitter taste, behavioral genetic approaches may be more useful for identifying genes encoding downstream signaling molecules or components of T2R-independent transduction mechanisms.
T4468 22845-22846 . denotes .
T4467 22835-22845 NNS denotes paralogues
T4466 22830-22834 IN denotes with
T4465 22812-22819 RB denotes tightly
T4464 22808-22811 RB denotes not
T4463 22803-22807 VBD denotes were
T4462 22793-22796 NN denotes PTC
T4461 22790-22792 CC denotes or
T4460 22797-22802 NN denotes taste
T4459 22780-22789 NN denotes saccharin
T4458 22777-22779 IN denotes to
T4457 22770-22776 VBN denotes linked
T4456 22764-22769 NNS denotes genes
T4455 22760-22763 DT denotes the
T4454 22758-22760 , denotes ,
T4453 22751-22758 RB denotes however
T4452 22749-22751 , denotes ,
T4451 22744-22749 NNS denotes cases
T4450 22738-22743 DT denotes these
T4449 22735-22737 IN denotes of
T4448 22730-22734 DT denotes both
T4447 22820-22829 VBN denotes clustered
T4446 22727-22729 IN denotes In
T4445 22726-22846 sentence denotes In both of these cases, however, the genes linked to saccharin or PTC taste were not tightly clustered with paralogues.
T4444 22725-22726 . denotes .
T4443 22724-22725 -RRB- denotes ]
T4442 22722-22724 CD denotes 18
T4441 22721-22722 -LRB- denotes [
T4440 22714-22720 NNS denotes humans
T4439 22711-22713 IN denotes in
T4438 22693-22698 NN denotes taste
T4031 20543-20545 DT denotes no
T4030 20534-20539 EX denotes there
T4029 20530-20533 RB denotes yet
T4028 20527-20529 IN denotes of
T4027 20540-20542 VBZ denotes is
T4026 20524-20526 IN denotes As
T4025 20523-20728 sentence denotes As of yet there is no evidence for quinine activation of T2Rs from functional assays of these receptors in heterologous cells or membrane preparations, likely due to the lipophilic nature of quinine [23].
T4024 20522-20523 . denotes .
T4023 20515-20522 NNS denotes stimuli
T4022 20509-20514 NN denotes taste
T4021 20502-20508 JJ denotes bitter
T4020 20499-20501 IN denotes of
T4019 20492-20498 NN denotes number
T4018 20490-20491 DT denotes a
T4017 20487-20489 IN denotes of
T4016 20477-20486 NN denotes detection
T4015 20473-20476 DT denotes the
T4014 20470-20472 IN denotes to
T4013 20465-20469 PRP denotes them
T4012 20457-20464 VBG denotes linking
T4011 20437-20447 JJ denotes functional
T4010 20433-20436 CC denotes and
T4009 20425-20432 JJ denotes genetic
T4008 20423-20424 -RRB- denotes )
T4007 20448-20456 NN denotes evidence
T4006 20422-20423 LS denotes 2
T4005 20421-20422 -LRB- denotes (
T4004 20417-20420 CC denotes and
T4003 20402-20410 NN denotes receptor
T4002 20411-20416 NNS denotes cells
T4001 20396-20401 NN denotes taste
T4000 20393-20395 IN denotes in
T3999 20376-20381 PRP$ denotes their
T3998 20374-20375 -RRB- denotes )
T3997 20382-20392 NN denotes expression
T3996 20373-20374 LS denotes 1
T3995 20372-20373 -LRB- denotes (
T3994 20370-20372 : denotes :
T3993 20368-20370 IN denotes to
T3406 18036-18037 . denotes .
T3405 18030-18036 NN denotes status
T3404 18023-18029 NN denotes taster
T3403 18018-18022 NN denotes QHCl
T3402 18013-18017 IN denotes with
T3401 18006-18012 VBZ denotes varies
T3400 18001-18005 WDT denotes that
T3399 17984-17990 JJ denotes single
T3398 17991-18000 NN denotes haplotype
T3397 17982-17983 DT denotes a
T3396 17965-17970 NN denotes Tas2r
T3395 17958-17964 JJ denotes entire
T3394 17971-17978 NN denotes cluster
T3393 17954-17957 DT denotes the
T3392 17979-17981 VBZ denotes is
T3391 17949-17953 IN denotes that
T3390 17938-17948 VBG denotes suggesting
T3389 17936-17938 , denotes ,
T3388 17935-17936 -RRB- denotes )
T3387 17932-17934 , denotes ,
T3386 17931-17932 CD denotes 6
T3385 17923-17930 NNS denotes Figures
T3384 17934-17935 CD denotes 7
T3383 17922-17923 -LRB- denotes (
T3382 17906-17911 NN denotes taste
T3381 17901-17905 NN denotes QHCl
T3380 17912-17921 NN denotes phenotype
T3379 17897-17900 DT denotes the
T3378 17892-17896 IN denotes with
T3377 17874-17880 RB denotes always
T3376 17863-17868 NN denotes Tas2r
T3375 17869-17873 NN denotes gene
T3374 17858-17862 DT denotes each
T3373 17855-17857 IN denotes of
T3372 17846-17854 NN denotes genotype
T3371 17842-17845 DT denotes the
T3370 17840-17842 , denotes ,
T3369 17881-17891 VBD denotes correlated
T3368 17829-17840 RB denotes Furthermore
T3367 17828-18037 sentence denotes Furthermore, the genotype of each Tas2r gene always correlated with the QHCl taste phenotype (Figures 6, 7), suggesting that the entire Tas2r cluster is a single haplotype that varies with QHCl taster status.
T3366 17827-17828 . denotes .
T3365 17826-17827 -RRB- denotes )
T3364 17823-17825 , denotes ,
T3363 17822-17823 CD denotes 5
T3362 17814-17821 NNS denotes Figures
T3361 17825-17826 CD denotes 6
T3360 17813-17814 -LRB- denotes (
T5009 25546-25555 NN denotes tolerance
T5008 25541-25545 DT denotes This
T5007 25540-25693 sentence denotes This tolerance may help to preserve the ability of T2R-expressing, bitter-sensitive taste cells to respond to a wide array of potentially toxic stimuli.
T5006 25539-25540 . denotes .
T5005 25530-25539 NN denotes variation
T5004 25521-25529 NN denotes sequence
T5003 25518-25520 IN denotes to
T5002 25509-25517 JJ denotes tolerant
T5001 25503-25508 RB denotes quite
T5000 25493-25502 NNS denotes receptors
T4999 25487-25492 VBN denotes tuned
T4998 25479-25486 RB denotes broadly
T4997 25470-25474 NNS denotes T2Rs
T4996 25475-25478 VBP denotes are
T4995 25465-25469 IN denotes that
T3776 19255-19267 NN denotes transduction
T3775 19251-19254 DT denotes the
T3774 19248-19250 IN denotes in
T3359 17797-17805 JJ denotes parental
T3358 17792-17796 JJ denotes same
T3357 17806-17812 NN denotes strain
T3356 17788-17791 DT denotes the
T3355 17783-17787 IN denotes from
T3354 17764-17766 JJ denotes RI
T3353 17753-17763 JJ denotes individual
T3352 17767-17771 NN denotes line
T3351 17750-17752 DT denotes an
T3350 17743-17749 IN denotes within
T3349 17737-17742 NN denotes Tas2r
T3348 17731-17736 DT denotes every
T3347 17729-17731 , denotes ,
T3346 17723-17729 VBN denotes tested
T3345 17714-17716 JJ denotes RI
T3344 17717-17722 NNS denotes lines
T3343 17710-17713 DT denotes all
T3342 17772-17782 VBD denotes originated
T3341 17706-17709 IN denotes For
T3340 17705-17828 sentence denotes For all RI lines tested, every Tas2r within an individual RI line originated from the same parental strain (Figures 5, 6).
T3339 17704-17705 . denotes .
T3338 17696-17698 JJ denotes RI
T3337 17692-17695 NN denotes BXD
T3336 17699-17704 NNS denotes lines
T3335 17688-17691 DT denotes the
T3334 17685-17687 IN denotes of
T3333 17674-17684 NN denotes generation
T3332 17670-17673 DT denotes the
T3331 17663-17669 IN denotes during
T3330 17653-17654 CD denotes 6
T3329 17642-17652 NN denotes chromosome
T3328 17635-17641 JJ denotes distal
T3327 17655-17662 NN denotes cluster
T3326 17631-17634 DT denotes the
T3325 17624-17630 IN denotes within
T3324 17603-17616 NN denotes recombination
T3323 17594-17602 JJ denotes apparent
T3322 17617-17623 NNS denotes events
T3321 17591-17593 DT denotes no
T3320 17581-17585 VBP denotes have
T3319 17575-17580 EX denotes there
T3318 17586-17590 VBN denotes been
T3317 17570-17574 IN denotes that
T3316 17556-17558 PRP denotes we
T3315 17554-17556 , denotes ,
T3314 17559-17569 VBD denotes discovered
T3313 17542-17554 RB denotes Surprisingly
T3312 17541-17705 sentence denotes Surprisingly, we discovered that there have been no apparent recombination events within the distal chromosome 6 cluster during the generation of the BXD RI lines.
T3311 17540-17541 . denotes .
T3310 17536-17540 NN denotes gene
T3309 17531-17535 DT denotes this
T3308 17527-17530 IN denotes for
T3307 17515-17517 NN denotes D2
T3306 17518-17526 NN denotes genotype
T3305 17511-17514 DT denotes the
T3304 17508-17510 IN denotes of
T3303 17497-17507 JJ denotes diagnostic
T3302 17481-17484 NN denotes PCR
T3301 17485-17492 NN denotes product
T3300 17479-17480 DT denotes a
T3299 17476-17478 IN denotes of
T3298 17468-17475 NN denotes absence
T3297 17464-17467 DT denotes the
T3296 17462-17464 , denotes ,
T3295 17458-17462 NNS denotes mice
T3294 17455-17457 NN denotes D2
T3293 17452-17454 IN denotes in
T3292 17437-17443 RB denotes likely
T3291 17434-17436 VBZ denotes is
T3290 17444-17451 VBN denotes deleted
T3289 17428-17433 WDT denotes which
T3288 17426-17428 , denotes ,
T3287 17418-17426 NN denotes Tas2r120
T3286 17493-17496 VBD denotes was
T3285 17414-17417 IN denotes For
T3284 17413-17541 sentence denotes For Tas2r120, which is likely deleted in D2 mice, the absence of a PCR product was diagnostic of the D2 genotype for this gene.
T3283 17412-17413 . denotes .
T3282 17399-17401 VB denotes be
T3281 17393-17398 MD denotes could
T3280 17368-17379 NN denotes restriction
T3260 17281-17282 . denotes .
T3259 17272-17274 NN denotes D2
T3258 17269-17271 CC denotes or
T3257 17266-17268 NN denotes B6
T3256 17275-17281 NN denotes allele
T3255 17264-17265 DT denotes a
T3254 17259-17263 IN denotes from
T3253 17245-17248 VBD denotes was
T3252 17233-17236 NN denotes PCR
T3251 17227-17232 NN denotes Tas2r
T3250 17216-17226 JJ denotes particular
T3249 17237-17244 NN denotes product
T3248 17214-17215 DT denotes a
T3247 17249-17258 VBN denotes amplified
T3246 17206-17213 IN denotes whether
T3245 17189-17196 RB denotes quickly
T3244 17186-17188 TO denotes to
T3243 17197-17205 VB denotes identify
T3242 17183-17185 PRP denotes us
T3241 17171-17176 MD denotes would
T3240 17177-17182 VB denotes allow
T3239 17166-17170 WDT denotes that
T3238 17145-17157 NN denotes endonuclease
T3237 17133-17144 NN denotes restriction
T3236 17158-17165 NNS denotes digests
T3235 17122-17132 JJ denotes diagnostic
T3234 17113-17121 VB denotes identify
T3233 17110-17112 TO denotes to
T3232 17105-17109 JJ denotes able
T3231 17097-17099 PRP denotes we
T3230 17095-17097 , denotes ,
T3229 17090-17095 NNS denotes cases
T3228 17085-17089 JJS denotes most
T3227 17100-17104 VBD denotes were
T3226 17082-17084 IN denotes In
T3225 17081-17282 sentence denotes In most cases, we were able to identify diagnostic restriction endonuclease digests that would allow us to quickly identify whether a particular Tas2r PCR product was amplified from a B6 or D2 allele.
T3224 17080-17081 . denotes .
T3223 17071-17080 VBD denotes contained
T3222 17066-17070 PRP denotes they
T3221 17058-17065 VBZ denotes alleles
T3220 17052-17057 NN denotes Tas2r
T3219 17048-17051 DT denotes the
T3218 17044-17047 IN denotes for
T3217 17042-17044 , denotes ,
T3216 17035-17042 NN denotes testing
T3215 17029-17034 NN denotes taste
T3214 17026-17028 IN denotes in
T3213 17017-17020 VBD denotes had
T3212 17014-17016 PRP denotes we
T3211 17021-17025 VBN denotes used
T3210 17009-17013 WDT denotes that
T3209 17006-17008 CD denotes 17
T3208 17002-17005 DT denotes the
T3207 16992-17001 VBG denotes including
T3206 16990-16992 , denotes ,
T3205 16982-16984 JJ denotes RI
T3204 16978-16981 NN denotes BXD
T3203 16968-16977 JJ denotes available
T3202 16985-16990 NNS denotes lines
T3201 16965-16967 CD denotes 29
T3200 16960-16964 IN denotes from
T3199 16956-16959 NN denotes DNA
T3198 16948-16955 JJ denotes genomic
T3197 16941-16947 VB denotes screen
T3196 16938-16940 TO denotes to
T3195 16925-16927 PRP denotes we
T3194 16923-16925 , denotes ,
T3193 16928-16937 VBD denotes proceeded
T3192 16914-16923 RB denotes Therefore
T3191 16913-17081 sentence denotes Therefore, we proceeded to screen genomic DNA from 29 available BXD RI lines, including the 17 that we had used in taste testing, for the Tas2r alleles they contained.
T3190 16912-16913 . denotes .
T3189 16901-16912 NN denotes sensitivity
T3188 16895-16900 NN denotes taste
T3187 16890-16894 NN denotes QHCl
T3186 16885-16889 IN denotes with
T3185 16870-16873 VBP denotes are
T3184 16874-16884 VBN denotes correlated
T3183 16856-16861 NN denotes Tas2r
T3182 16862-16869 NNS denotes alleles
T3181 16850-16855 WDT denotes which
T3180 16838-16849 VBG denotes determining
T3179 16835-16837 IN denotes by
T3178 16825-16830 NN denotes taste
T3177 16820-16824 NN denotes QHCl
T3176 16831-16834 NN denotes QTL
T3175 16816-16819 DT denotes the
T3174 16813-16815 IN denotes of
T3173 16793-16801 JJ denotes physical
T3172 16802-16812 NNS denotes boundaries
T3171 16789-16792 DT denotes the
T3170 16782-16788 VB denotes narrow
T3169 16779-16781 TO denotes to
T3168 16770-16778 JJ denotes possible
T3167 16761-16766 MD denotes might
T3166 16758-16760 PRP denotes it
T3165 16767-16769 VB denotes be
T3164 16753-16757 IN denotes that
T3163 16728-16734 JJ denotes inbred
T3162 16724-16727 CD denotes two
T3161 16735-16742 NNS denotes strains
T3160 16718-16723 DT denotes these
T3159 16715-16717 IN denotes in
T3158 16705-16714 NNS denotes receptors
T3157 16693-16704 JJ denotes orthologous
T3156 16685-16692 IN denotes between
T3155 16743-16752 VBD denotes suggested
T3144 16142-16146 NNS denotes data
T3143 16151-16156 VBN denotes shown
T3142 16141-16142 -LRB- denotes (
T3141 16136-16140 NNS denotes T2Rs
T3140 16132-16135 DT denotes the
T3139 16129-16131 IN denotes of
T3138 16109-16122 JJ denotes extracellular
T3137 16105-16108 CD denotes two
T3136 16099-16104 JJ denotes first
T3135 16123-16128 NNS denotes loops
T3134 16095-16098 DT denotes the
T3133 16088-16094 IN denotes within
T3132 16079-16083 VBN denotes seen
T3131 16066-16070 NN denotes acid
T3130 16060-16065 NN denotes amino
T3129 16071-16078 NNS denotes changes
T3128 16056-16059 DT denotes the
T3127 16053-16055 IN denotes of
T3126 16051-16052 NN denotes %
T3125 16049-16051 CD denotes 23
T3124 16047-16049 , denotes ,
T3123 16038-16047 NNS denotes receptors
T3122 16034-16037 DT denotes the
T3121 16031-16033 IN denotes of
T3120 16023-16030 NNS denotes regions
T3119 16019-16022 DT denotes all
T3118 16016-16018 IN denotes in
T3117 16084-16087 VBP denotes are
T3116 16006-16009 VBP denotes are
T3115 15996-15998 NN denotes D2
T3114 15992-15995 CC denotes and
T3113 15999-16005 NNS denotes Tas2rs
T3112 15989-15991 NN denotes B6
T3111 15981-15988 IN denotes between
T3110 15972-15980 NNS denotes residues
T3109 15960-15971 JJ denotes polymorphic
T3108 16010-16015 VBN denotes found
T3107 15951-15959 IN denotes Although
T3106 15950-16158 sentence denotes Although polymorphic residues between B6 and D2 Tas2rs are found in all regions of the receptors, 23% of the amino acid changes seen are within the first two extracellular loops of the T2Rs (data not shown).
T3105 15949-15950 . denotes .
T3104 15948-15949 -RRB- denotes )
T3103 15939-15942 RB denotes not
T3102 15934-15938 NNS denotes data
T3101 15943-15948 VBN denotes shown
T3100 15933-15934 -LRB- denotes (
T3099 15927-15932 NNS denotes exons
T3098 15920-15926 NN denotes coding
T3097 15913-15919 IN denotes within
T3096 15905-15912 JJ denotes present
T3095 15901-15904 VBP denotes are
T3094 15876-15886 NN denotes nucleotide
T3093 15869-15875 JJ denotes single
T3092 15887-15900 NNS denotes polymorphisms
T3091 15865-15868 CD denotes 307
T3090 15861-15864 CC denotes and
T3089 15859-15861 , denotes ,
T3088 15852-15854 NN denotes D2
T3087 15848-15851 CC denotes and
T3086 15855-15859 NNS denotes mice
T3085 15845-15847 NN denotes B6
T3084 15842-15844 IN denotes in
T3083 15834-15841 NNS denotes alleles
T3082 15824-15833 JJ denotes different
T3081 15810-15818 VBN denotes examined
T3080 15819-15823 VBP denotes have
T3079 15800-15802 CD denotes 24
T3078 15803-15809 NNS denotes Tas2rs
T3077 15796-15799 DT denotes All
T3076 15795-15950 sentence denotes All 24 Tas2rs examined have different alleles in B6 and D2 mice, and 307 single nucleotide polymorphisms are present within coding exons (data not shown).
T3075 15794-15795 . denotes .
T3074 15776-15784 NN denotes missense
T3073 15773-15775 CD denotes 16
T3072 15769-15772 CC denotes and
T3071 15785-15794 NNS denotes mutations
T3070 15765-15768 CD denotes one
T3069 15757-15764 IN denotes between
T3068 15747-15756 VBD denotes contained
T3067 15737-15739 CD denotes 19
T3066 15727-15736 VBG denotes remaining
T3065 15740-15746 NNS denotes Tas2rs
T3064 15723-15726 DT denotes The
T3063 15722-15795 sentence denotes The remaining 19 Tas2rs contained between one and 16 missense mutations.
T3062 15721-15722 . denotes .
T3061 15715-15721 NN denotes strain
T3060 15710-15714 DT denotes this
T3059 15707-15709 IN denotes in
T3058 15695-15706 NNS denotes pseudogenes
T3057 15688-15691 MD denotes may
T3056 15678-15681 CD denotes two
T3055 15682-15687 NNS denotes genes
T3054 15672-15677 DT denotes these
T3053 15670-15671 : denotes ;
T3052 15659-15670 NN denotes termination
T3051 15649-15658 JJ denotes premature
T3050 15645-15648 CC denotes and
T3049 15638-15644 NNS denotes shifts
T3048 15632-15637 NN denotes frame
T3047 15625-15631 VBP denotes create
T3046 15620-15624 WDT denotes that
T3045 15610-15619 NNS denotes deletions
T3042 15581-15589 NN denotes missense
T3041 15590-15599 NNS denotes mutations
T3040 15572-15580 JJ denotes numerous
T3039 15692-15694 VB denotes be
T3038 15560-15562 , denotes ,
T3037 15552-15560 NN denotes Tas2r117
T3036 15548-15551 CC denotes and
T3035 15539-15547 NN denotes Tas2r103
T3034 15537-15539 , denotes ,
T3033 15562-15571 VBD denotes contained
T3032 15527-15529 NN denotes D2
T3031 15530-15537 NNS denotes alleles
T3030 15523-15526 CD denotes Two
T3029 15522-15722 sentence denotes Two D2 alleles, Tas2r103 and Tas2r117, contained numerous missense mutations and small deletions that create frame shifts and premature termination; these two genes may be pseudogenes in this strain.
T3028 15521-15522 . denotes .
T3027 15517-15521 NNS denotes mice
T3026 15514-15516 NN denotes D2
T3025 15511-15513 IN denotes in
T3024 15500-15502 VBZ denotes is
T3023 15494-15499 NN denotes Tas2r
T3022 15489-15493 DT denotes this
T3021 15503-15510 VBN denotes deleted
T3020 15484-15488 IN denotes that
T3019 15473-15483 VBG denotes suggesting
T3018 15471-15473 , denotes ,
T3017 15470-15471 -RRB- denotes )
T3016 15469-15470 CD denotes 2
T3015 15453-15463 JJ denotes Additional
T3014 15464-15468 NN denotes file
T3013 15452-15453 -LRB- denotes (
T3012 15435-15451 NNS denotes oligonucleotides
T3011 15432-15434 IN denotes of
T3010 15426-15431 NNS denotes pairs
T3009 15422-15425 CD denotes two
T3008 15419-15421 IN denotes of
T3007 15412-15418 DT denotes either
T3006 15406-15411 VBG denotes using
T3005 15404-15405 -RRB- denotes )
T3004 15403-15404 CD denotes 5
T3003 15396-15402 NN denotes Figure
T3002 15395-15396 -LRB- denotes (
T3001 15383-15390 JJ denotes genomic
T3000 15391-15394 NN denotes DNA
T2999 15380-15382 NN denotes D2
T2998 15375-15379 IN denotes from
T2997 15362-15364 VB denotes be
T2996 15358-15361 RB denotes not
T2995 15352-15357 MD denotes could
T2994 15350-15352 , denotes ,
T2993 15342-15350 NN denotes Tas2r120
T2992 15340-15342 , denotes ,
T2991 15365-15374 VBN denotes amplified
T2990 15335-15340 JJ denotes third
T2989 15333-15334 DT denotes A
T2988 15332-15522 sentence denotes A third, Tas2r120, could not be amplified from D2 genomic DNA (Figure 5) using either of two pairs of oligonucleotides (Additional file 2), suggesting that this Tas2r is deleted in D2 mice.
T2987 15331-15332 . denotes .
T2986 15330-15331 -RRB- denotes )
T2985 15321-15324 RB denotes not
T2984 15316-15320 NNS denotes data
T2983 15325-15330 VBN denotes shown
T2982 15315-15316 -LRB- denotes (
T2981 15304-15308 NN denotes acid
T2980 15298-15303 NN denotes amino
T2979 15309-15314 NN denotes level
T2978 15294-15297 DT denotes the
T2977 15291-15293 IN denotes at
T2976 15283-15290 NNS denotes strains
T2975 15276-15282 IN denotes across
T2974 15266-15275 JJ denotes identical
T2973 15259-15261 , denotes ,
T2972 15251-15259 NN denotes Tas2r124
T2971 15247-15250 CC denotes and
T2970 15238-15246 NN denotes Tas2r106
T2969 15236-15238 , denotes ,
T2968 15228-15236 VBN denotes examined
T2967 15214-15219 NN denotes Tas2r
T2966 15208-15209 HYPH denotes -
T2965 15209-15213 CD denotes four
T2964 15202-15208 CD denotes twenty
T2963 15220-15227 NNS denotes alleles
T2962 15198-15201 DT denotes the
T2961 15195-15197 IN denotes of
T2960 15191-15194 CD denotes two
T2959 15186-15190 RB denotes only
T2958 15261-15265 VBD denotes were
T2957 15181-15185 IN denotes that
T2956 15157-15159 NN denotes D2
T2955 15153-15156 CC denotes and
T2954 15160-15171 NNS denotes orthologues
T2953 15150-15152 NN denotes B6
T2952 15147-15149 IN denotes of
T2951 15137-15146 NNS denotes sequences
T2950 15133-15136 DT denotes the
T2949 15130-15132 IN denotes of
T2948 15172-15180 VBD denotes revealed
T2947 15118-15129 NNS denotes Comparisons
T2946 15117-15332 sentence denotes Comparisons of the sequences of B6 and D2 orthologues revealed that only two of the twenty-four Tas2r alleles examined, Tas2r106 and Tas2r124, were identical across strains at the amino acid level (data not shown).
T2945 15116-15117 . denotes .
T2944 15107-15116 VBN denotes sequenced
T2943 15103-15106 CC denotes and
T2942 15095-15102 NNS denotes vectors
T2941 15087-15094 NN denotes cloning
T2940 15082-15086 IN denotes into
T2939 15067-15071 VBD denotes were
T2938 15072-15081 VBN denotes subcloned
T2937 15058-15066 NNS denotes products
T2936 15054-15057 NN denotes PCR
T2935 15053-15117 sentence denotes PCR products were subcloned into cloning vectors and sequenced.
T2934 15052-15053 . denotes .
T2933 15041-15048 JJ denotes genomic
T2932 15049-15052 NN denotes DNA
T2931 15038-15040 NN denotes D2
T2930 15033-15037 IN denotes from
T2929 15017-15023 NN denotes coding
T2928 15011-15016 NN denotes Tas2r
T2927 15024-15032 NN denotes sequence
T2926 15006-15010 DT denotes each
T2925 14993-14995 PRP denotes we
T2924 14991-14993 , denotes ,
T2923 14985-14991 NNS denotes oligos
T2922 14979-14984 DT denotes these
T2921 14996-15005 VBD denotes amplified
T2920 14973-14978 VBG denotes Using
T2919 14972-15053 sentence denotes Using these oligos, we amplified each Tas2r coding sequence from D2 genomic DNA.
T2918 14971-14972 . denotes .
T2917 14970-14971 -RRB- denotes ]
T2916 14969-14970 CD denotes 2
T2915 14964-14968 NN denotes file
T2914 14953-14963 JJ denotes Additional
T2913 14949-14952 VB denotes see
T2912 14948-14949 -LRB- denotes [
T2911 14935-14941 JJ denotes intact
T2910 14942-14947 NN denotes Tas2r
T2909 14930-14934 DT denotes each
T2908 14927-14929 IN denotes of
T2907 14911-14917 NN denotes coding
T3279 17357-17367 JJ denotes diagnostic
T3278 17380-17392 NN denotes endonuclease
T3277 17354-17356 DT denotes no
T3276 17402-17412 VBN denotes identified
T3275 17348-17353 WRB denotes where
T3274 17346-17347 -RRB- denotes )
T3273 17338-17346 NN denotes Tas2r110
T3272 17334-17337 CC denotes and
T3271 17325-17333 NN denotes Tas2r114
T3270 17323-17325 , denotes ,
T3269 17315-17323 NN denotes Tas2r104
T3268 17314-17315 -LRB- denotes (
T3267 17308-17313 NNS denotes genes
T3266 17302-17307 CD denotes three
T3265 17290-17293 RB denotes not
T3264 17286-17289 VBD denotes did
T3263 17294-17301 VB denotes analyze
T3262 17283-17285 PRP denotes We
T3261 17282-17413 sentence denotes We did not analyze three genes (Tas2r104, Tas2r114 and Tas2r110) where no diagnostic restriction endonuclease could be identified.
T2906 14918-14926 NN denotes sequence
T2905 14907-14910 DT denotes the
T2904 14898-14906 VBG denotes flanking
T2903 14890-14897 NNS denotes regions
T2902 14879-14889 JJ denotes non-coding
T2901 14876-14878 IN denotes to
T2900 14859-14875 NNS denotes oligonucleotides
T2899 14850-14858 VBD denotes designed
T2898 14847-14849 PRP denotes We
T2897 14846-14972 sentence denotes We designed oligonucleotides to non-coding regions flanking the coding sequence of each intact Tas2r [see Additional file 2].
T2896 14845-14846 . denotes .
T2895 14844-14845 -RRB- denotes )
T2894 14843-14844 CD denotes 4
T2893 14836-14842 NN denotes Figure
T2892 14835-14836 -LRB- denotes (
T2891 14833-14834 -RRB- denotes ]
T2890 14831-14833 CD denotes 19
T2889 14830-14831 -LRB- denotes [
T2888 14825-14829 NNS denotes mice
T2887 14822-14824 NN denotes B6
T2886 14819-14821 IN denotes of
T2885 14809-14810 CD denotes 6
T2884 14798-14808 NN denotes chromosome
T2883 14791-14797 JJ denotes distal
T2882 14811-14818 NN denotes cluster
T2881 14787-14790 DT denotes the
T2880 14784-14786 IN denotes in
T2879 14768-14772 VBN denotes been
T2878 14763-14767 VBP denotes have
T2877 14761-14763 , denotes ,
T2876 14744-14749 NN denotes Tas2r
T2875 14735-14743 JJ denotes apparent
T2874 14750-14761 NNS denotes pseudogenes
T2873 14729-14734 CD denotes three
T2872 14724-14728 IN denotes with
T2871 14718-14723 IN denotes along
T2870 14716-14718 , denotes ,
T2869 14773-14783 VBN denotes identified
T2868 14703-14709 JJ denotes intact
T2867 14710-14716 NNS denotes Tas2rs
T2866 14697-14698 HYPH denotes -
T2865 14698-14702 CD denotes four
T2864 14691-14697 CD denotes Twenty
T2863 14690-14846 sentence denotes Twenty-four intact Tas2rs, along with three apparent Tas2r pseudogenes, have been identified in the distal chromosome 6 cluster of B6 mice [19] (Figure 4).
T2862 14689-14690 . denotes .
T2861 14666-14679 NN denotes insensitivity
T2860 14660-14665 NN denotes taste
T2859 14655-14659 NN denotes QHCl
T2858 14680-14689 NN denotes phenotype
T2857 14651-14654 DT denotes the
T2856 14646-14650 IN denotes with
T2855 14630-14635 MD denotes would
T2854 14621-14623 NN denotes D2
T2853 14614-14620 JJ denotes single
T2852 14624-14629 NN denotes Tas2r
T2851 14612-14613 DT denotes a
T2850 14609-14611 IN denotes of
T2849 14593-14599 VBG denotes coding
T2848 14600-14608 NN denotes sequence
T2847 14589-14592 DT denotes the
T2846 14582-14588 IN denotes within
T2845 14573-14581 NN denotes mutation
T2844 14570-14572 CC denotes or
T2843 14561-14569 NN denotes deletion
T2842 14636-14645 VB denotes correlate
T2841 14556-14560 IN denotes that
T2840 14545-14555 NN denotes likelihood
T2839 14541-14544 DT denotes the
T2838 14538-14540 IN denotes on
T2837 14520-14529 RB denotes initially
T2836 14517-14519 PRP denotes we
T2835 14515-14517 , denotes ,
T2834 14502-14515 NNS denotes possibilities
T2833 14496-14501 JJ denotes valid
T2832 14490-14492 TO denotes to
T2831 14484-14489 DT denotes these
T2830 14481-14483 IN denotes of
T2829 14493-14495 VB denotes be
T2828 14475-14480 CD denotes three
T2827 14471-14474 DT denotes all
T2741 14071-14073 VBZ denotes is
T2740 14053-14054 LS denotes 1
T2739 14052-14053 -LRB- denotes (
T2738 14050-14052 : denotes :
T2737 14028-14034 JJ denotes likely
T2736 14035-14050 NNS denotes characteristics
T2735 14022-14027 CD denotes three
T2734 14019-14021 IN denotes of
T2733 14015-14018 CD denotes one
T2732 14001-14006 MD denotes would
T2731 13989-13994 NN denotes Tas2r
T2730 13987-13988 -RRB- denotes )
T2729 13983-13987 JJR denotes more
T2728 13980-13982 CC denotes or
T2727 13979-13980 -LRB- denotes (
T2726 13995-14000 NNS denotes genes
T2725 13975-13978 CD denotes one
T2724 14007-14014 VB denotes exhibit
T2723 13970-13974 IN denotes that
T2722 14407-14414 VBZ denotes affects
T2721 13956-13961 MD denotes would
T2720 13953-13955 PRP denotes we
T2719 13951-13953 , denotes ,
T2718 13936-13947 NN denotes sensitivity
T2717 13930-13935 NN denotes taste
T2716 13925-13929 NN denotes QHCl
T2715 13923-13924 CD denotes 6
T2714 13912-13922 NN denotes chromosome
T2713 13948-13951 NN denotes QTL
T2712 13908-13911 DT denotes the
T2711 13962-13969 VB denotes predict
T2710 13890-13891 -RRB- denotes )
T2709 13886-13890 JJR denotes more
T2708 13883-13885 CC denotes or
T2707 13882-13883 -LRB- denotes (
T2706 13892-13898 NNS denotes Tas2rs
T2705 13878-13881 CD denotes one
T2704 13899-13907 VBP denotes underlie
T2703 13875-13877 IN denotes If
T2702 13874-14449 sentence denotes If one (or more) Tas2rs underlie the chromosome 6 QHCl taste sensitivity QTL, we would predict that one (or more) Tas2r genes would exhibit one of three likely characteristics: (1) A Tas2r allele is a pseudogene, or is deleted, in D2 (QHCL-insensitive), but not B6 (QHCl-sensitive), mice; (2) Missense mutations in the single coding exon of a D2 Tas2r allele impact protein functions such as ligand binding or receptor coupling to downstream signaling cascades; (3) Mutations in noncoding or regulatory regions of a D2 Tas2r allele affects expression of the protein product.
T2701 13867-13874 NNS denotes alleles
T2700 13863-13866 NN denotes T2R
T3044 15604-15609 JJ denotes small
T3043 15600-15603 CC denotes and
T2456 12670-12675 RBS denotes least
T2455 12667-12669 RB denotes at
T2454 12664-12666 IN denotes of
T2453 12654-12663 NN denotes detection
T2452 12650-12653 DT denotes the
T2451 12647-12649 IN denotes in
T2450 12642-12646 NN denotes role
T2449 12636-12641 PRP$ denotes their
T2448 12632-12635 CC denotes and
T2447 12630-12632 , denotes ,
T2446 12616-12624 NN denotes receptor
T2445 12625-12630 NNS denotes cells
T2444 12610-12615 NN denotes taste
T2443 12607-12609 IN denotes in
T2442 12583-12595 VBN denotes demonstrated
T2441 12596-12606 NN denotes expression
T2440 12577-12582 PRP$ denotes their
T2439 12575-12577 , denotes ,
T2438 12562-12568 VBN denotes linked
T2437 12569-12575 NN denotes marker
T2436 12558-12561 DT denotes the
T2435 12555-12557 IN denotes to
T2434 12545-12554 NN denotes proximity
T2433 12539-12544 PRP$ denotes their
T2432 12536-12538 IN denotes of
T2431 12710-12722 VBD denotes hypothesized
T2430 12528-12535 IN denotes Because
T2429 12527-12829 sentence denotes Because of their proximity to the linked marker, their demonstrated expression in taste receptor cells, and their role in the detection of at least some bitter-tasting compounds, we hypothesized that one or more of the 24 Tas2rs at this locus were responsible for the major QHCl taste sensitivity QTL.
T2428 12526-12527 . denotes .
T2427 12525-12526 -RRB- denotes )
T2426 12524-12525 CD denotes 4
T2425 12515-12517 , denotes ,
T2424 12514-12515 CD denotes 3
T2423 12507-12513 NN denotes Figure
T2422 12517-12523 NN denotes Figure
T2421 12506-12507 -LRB- denotes (
T2420 12498-12505 NN denotes D6Mit13
T2419 12495-12497 IN denotes of
T2418 12490-12494 NN denotes side
T2417 12483-12489 DT denotes either
T2416 12480-12482 IN denotes on
T2415 12468-12470 NN denotes Mb
T2414 12464-12467 CD denotes 1.2
T2413 12471-12479 NN denotes interval
T2412 12462-12463 DT denotes a
T2411 12455-12461 IN denotes within
T2410 12445-12454 VBN denotes clustered
T2409 12435-12438 VBP denotes are
T2408 12433-12434 -RRB- denotes )
T2407 12429-12433 NNS denotes T2Rs
T2406 12425-12428 DT denotes the
T2405 12418-12424 VBP denotes encode
T2404 12412-12417 WDT denotes which
T2403 12411-12412 -LRB- denotes (
T2402 12439-12444 VBN denotes found
T2401 12399-12404 NN denotes Tas2r
T2400 12405-12410 NNS denotes genes
T2399 12395-12398 DT denotes The
T2398 12394-12527 sentence denotes The Tas2r genes (which encode the T2Rs) are found clustered within a 1.2 Mb interval on either side of D6Mit13 (Figure 3, Figure 4).
T2397 12393-12394 . denotes .
T2396 12378-12383 NN denotes taste
T2395 12384-12393 NNS denotes receptors
T2394 12372-12373 HYPH denotes -
T2393 12373-12377 NN denotes type
T2392 12369-12372 NN denotes T2R
T2391 12365-12368 CC denotes and
T2390 12363-12365 , denotes ,
T2389 12348-12349 HYPH denotes -
T2388 12349-12353 JJ denotes like
T2387 12342-12348 NN denotes lectin
T2386 12354-12363 NNS denotes receptors
T2385 12330-12336 NN denotes killer
T2384 12337-12341 NN denotes cell
T2383 12322-12329 JJ denotes natural
T2382 12320-12322 : denotes :
T2381 12303-12311 NN denotes receptor
T2380 12297-12302 JJ denotes large
T2379 12312-12320 NNS denotes families
T2378 12293-12296 CD denotes two
T2377 12290-12292 IN denotes of
T2376 12282-12289 NNS denotes members
T2375 12269-12274 WDT denotes which
T2374 12266-12268 IN denotes of
T2373 12259-12265 CD denotes eleven
T2372 12255-12258 IN denotes but
T2371 12275-12281 VBP denotes encode
T2370 12251-12254 DT denotes all
T2369 12249-12251 , denotes ,
T2368 12244-12249 NNS denotes genes
T2367 12238-12243 JJ denotes known
T2366 12235-12237 IN denotes of
T2365 12228-12234 NN denotes number
T2364 12226-12227 DT denotes a
T2363 12217-12225 VBZ denotes contains
T2362 12210-12216 NN denotes region
T2361 12205-12209 DT denotes This
T2360 12204-12394 sentence denotes This region contains a number of known genes, all but eleven of which encode members of two large receptor families: natural killer cell lectin-like receptors, and T2R-type taste receptors.
T2359 12203-12204 . denotes .
T2358 12202-12203 -RRB- denotes )
T2357 12201-12202 CD denotes 3
T2356 12194-12200 NN denotes Figure
T2355 12193-12194 -LRB- denotes (
T2354 12190-12192 NN denotes Mb
T2353 12181-12185 IN denotes than
T2352 12186-12189 CD denotes 5.0
T2351 12176-12180 JJR denotes less
T2350 12167-12168 CD denotes 6
T2349 12156-12166 NN denotes chromosome
T2348 12151-12155 NN denotes QHCl
T2347 12169-12172 NN denotes QTL
T2346 12147-12150 DT denotes the
T2345 12144-12146 IN denotes of
T2344 12139-12143 NN denotes size
T2343 12135-12138 DT denotes the
T2342 12133-12135 , denotes ,
T2341 12117-12123 NN denotes marker
T2340 12124-12133 NNS denotes positions
T2339 12111-12116 DT denotes these
T2338 12108-12110 IN denotes on
T2337 12173-12175 VBZ denotes is
T2336 12102-12107 VBN denotes Based
T2335 12101-12204 sentence denotes Based on these marker positions, the size of the QHCl chromosome 6 QTL is less than 5.0 Mb (Figure 3).
T2334 12100-12101 . denotes .
T2333 12091-12093 NN denotes B6
T2332 12084-12090 JJ denotes public
T2331 12094-12100 NN denotes genome
T2330 12080-12083 DT denotes the
T2329 12077-12079 IN denotes of
T2328 12066-12070 CD denotes 2004
T2327 12064-12066 , denotes ,
T2326 12061-12064 NNP denotes May
T2325 12071-12076 NN denotes build
T2324 12057-12060 DT denotes the
T2323 12054-12056 IN denotes on
T2322 12048-12053 VBN denotes based
T2321 12041-12047 FW denotes silico
T2826 14530-14537 VBD denotes focused
T2825 14457-14459 PRP denotes we
T2824 14460-14470 VBD denotes considered
T2823 14450-14456 IN denotes Though
T2822 14449-14690 sentence denotes Though we considered all three of these to be valid possibilities, we initially focused on the likelihood that deletion or mutation within the coding sequence of a single D2 Tas2r would correlate with the QHCl taste insensitivity phenotype.
T2821 14448-14449 . denotes .
T2820 14433-14440 NN denotes protein
T2819 14441-14448 NN denotes product
T2818 14429-14432 DT denotes the
T2817 14426-14428 IN denotes of
T2816 14415-14425 NN denotes expression
T2815 14394-14399 NN denotes Tas2r
T2814 14391-14393 NN denotes D2
T2813 14400-14406 NN denotes allele
T2812 14389-14390 DT denotes a
T2811 14386-14388 IN denotes of
T2810 14367-14377 JJ denotes regulatory
T2809 14364-14366 CC denotes or
T2808 14378-14385 NNS denotes regions
T2807 14354-14363 JJ denotes noncoding
T2806 14351-14353 IN denotes in
T2805 14341-14350 NNS denotes Mutations
T2804 14339-14340 -RRB- denotes )
T2803 14338-14339 LS denotes 3
T2802 14337-14338 -LRB- denotes (
T2801 14335-14336 : denotes ;
T2800 14317-14326 NN denotes signaling
T2799 14327-14335 NNS denotes cascades
T2798 14306-14316 JJ denotes downstream
T2797 14303-14305 IN denotes to
T2796 14294-14302 NN denotes coupling
T2795 14285-14293 NN denotes receptor
T2794 14282-14284 CC denotes or
T2793 14274-14281 NN denotes binding
T2792 14267-14273 NN denotes ligand
T2791 14264-14266 IN denotes as
T2790 14259-14263 JJ denotes such
T2789 14249-14258 NNS denotes functions
T2788 14241-14248 NN denotes protein
T2787 14221-14226 NN denotes Tas2r
T2786 14218-14220 NN denotes D2
T2785 14227-14233 NN denotes allele
T2784 14216-14217 DT denotes a
T2783 14213-14215 IN denotes of
T2782 14201-14207 VBG denotes coding
T2781 14194-14200 JJ denotes single
T2780 14208-14212 NN denotes exon
T2779 14190-14193 DT denotes the
T2778 14187-14189 IN denotes in
T2777 14177-14186 NNS denotes mutations
T2776 14168-14176 NN denotes Missense
T2775 14166-14167 -RRB- denotes )
T2774 14234-14240 VBP denotes impact
T2773 14165-14166 LS denotes 2
T2772 14164-14165 -LRB- denotes (
T2771 14162-14163 : denotes ;
T2770 14156-14158 , denotes ,
T2769 14155-14156 -RRB- denotes )
T2768 14145-14146 HYPH denotes -
T2767 14141-14145 NN denotes QHCl
T2766 14146-14155 JJ denotes sensitive
T2765 14140-14141 -LRB- denotes (
T2764 14137-14139 NN denotes B6
T2763 14133-14136 RB denotes not
T2762 14129-14132 CC denotes but
T2761 14127-14129 , denotes ,
T2760 14126-14127 -RRB- denotes )
T2759 14114-14115 HYPH denotes -
T2758 14110-14114 NN denotes QHCL
T2757 14115-14126 JJ denotes insensitive
T2756 14109-14110 -LRB- denotes (
T2755 14158-14162 NNS denotes mice
T2754 14106-14108 NN denotes D2
T2753 14103-14105 IN denotes in
T2752 14101-14103 , denotes ,
T2751 14094-14101 VBN denotes deleted
T2750 14091-14093 VBZ denotes is
T2749 14088-14090 CC denotes or
T2748 14086-14088 , denotes ,
T2747 14076-14086 NN denotes pseudogene
T2746 14074-14075 DT denotes a
T2745 14058-14063 NN denotes Tas2r
T2744 14064-14070 NN denotes allele
T2743 14056-14057 NN denotes A
T2742 14054-14055 -RRB- denotes )
T2320 12038-12040 FW denotes in
T2319 12024-12027 VBD denotes was
T2318 12022-12024 , denotes ,
T2317 12014-12022 NN denotes D6Mit374
T2316 12003-12013 NN denotes D6Mit61and
T2315 12001-12003 , denotes ,
T2314 11985-11993 JJ denotes unlinked
T2313 11977-11984 JJS denotes closest
T2312 11973-11976 CD denotes two
T2311 11994-12001 NNS denotes markers
T2310 11969-11972 DT denotes the
T2309 11965-11968 CC denotes and
T2308 11963-11965 , denotes ,
T2307 11956-11963 NN denotes D6Mit13
T2306 11954-11956 , denotes ,
T2305 11941-11947 VBN denotes linked
T2304 11934-11940 JJ denotes single
T2303 11948-11954 NN denotes marker
T2302 11930-11933 DT denotes the
T2301 11927-11929 IN denotes of
T2300 12028-12037 VBN denotes performed
T2299 11919-11926 NN denotes mapping
T2298 11910-11918 JJ denotes Physical
T2297 11909-12101 sentence denotes Physical mapping of the single linked marker, D6Mit13, and the two closest unlinked markers, D6Mit61and D6Mit374, was performed in silico based on the May, 2004 build of the public B6 genome.
T2296 11908-11909 . denotes .
T2295 11900-11908 NN denotes D6Mit374
T2294 11896-11899 CC denotes and
T2293 11888-11895 NN denotes D6Mit61
T2292 11880-11887 IN denotes between
T2291 11873-11879 NN denotes region
T2290 11869-11872 DT denotes the
T2289 11866-11868 IN denotes to
T2288 11848-11854 RB denotes likely
T2287 11843-11847 RBS denotes most
T2286 11855-11865 VBN denotes restricted
T2285 11840-11842 VBZ denotes is
T2284 11836-11839 CC denotes but
T2283 11834-11836 , denotes ,
T2282 11826-11834 NN denotes D6Mit374
T2281 11822-11825 CC denotes and
T2280 11813-11821 NN denotes D6Mit254
T2279 11805-11812 IN denotes between
T2278 11800-11804 VBZ denotes lies
T2277 11795-11799 WDT denotes that
T2276 11793-11794 CD denotes 6
T2275 11782-11792 NN denotes chromosome
T2274 11776-11781 NN denotes mouse
T2273 11773-11775 IN denotes of
T2272 11765-11772 NN denotes portion
T2271 11760-11764 DT denotes that
T2270 11757-11759 IN denotes as
T2269 11734-11748 RB denotes conservatively
T2268 11731-11733 VB denotes be
T2267 11727-11730 MD denotes can
T2266 11714-11717 NN denotes QTL
T2265 11718-11726 NN denotes interval
T2264 11709-11713 DT denotes this
T2263 11707-11709 , denotes ,
T2262 11749-11756 VBN denotes defined
T2261 11698-11707 RB denotes Therefore
T2260 11697-11909 sentence denotes Therefore, this QTL interval can be conservatively defined as that portion of mouse chromosome 6 that lies between D6Mit254 and D6Mit374, but is most likely restricted to the region between D6Mit61 and D6Mit374.
T2259 11696-11697 . denotes .
T2258 11688-11692 NN denotes QHCl
T2257 11693-11696 NN denotes QTL
T2256 11684-11687 DT denotes the
T2255 11681-11683 IN denotes to
T2254 11672-11680 JJ denotes unlinked
T2253 11661-11668 NN denotes D6Mit61
T2252 11669-11671 VBZ denotes is
T2251 11656-11660 IN denotes that
T2250 11645-11655 VBG denotes indicating
T2249 11643-11645 , denotes ,
T2248 11642-11643 -RRB- denotes ]
T2247 11639-11640 , denotes ,
T2246 11637-11639 CD denotes 39
T2245 11640-11642 CD denotes 40
T2244 11636-11637 -LRB- denotes [
T2243 11628-11635 NN denotes D6Mit61
T2242 11624-11627 IN denotes for
T2241 11612-11614 NN denotes B6
T1968 10073-10084 JJ denotes significant
T1967 10085-10089 NNS denotes QTLs
T1966 10070-10072 DT denotes No
T1965 10069-10276 sentence denotes No significant QTLs were identified for DB taste sensitivity, although several associations with markers on chromosomes 2,8 and 12 were "suggestive" (LRS > 9.4, genome-wide p = 0.65; see Additional File 1).
T1964 10068-10069 . denotes .
T1963 10067-10068 -RRB- denotes )
T1962 10066-10067 -RRB- denotes ]
T1961 10063-10064 -LRB- denotes [
T1960 10059-10063 CD denotes 0.30
T1959 10051-10058 NN denotes version
T1958 10064-10066 CD denotes 38
T1957 10050-10051 -LRB- denotes (
T1956 10046-10049 NNP denotes QTX
T1955 10038-10045 NNP denotes Manager
T1954 10034-10037 NNP denotes Map
T1953 10028-10033 VBG denotes using
T1952 10014-10017 VBD denotes was
T1951 10018-10027 VBN denotes conducted
T1950 10005-10013 NN denotes analysis
T1949 9997-10004 NN denotes Linkage
T1948 9996-10069 sentence denotes Linkage analysis was conducted using Map Manager QTX (version 0.30[38]).
T1947 9989-9996 NN denotes mapping
T1946 9985-9988 NN denotes QTL
T1841 9982-9983 . denotes .
T1840 9981-9982 -RRB- denotes )
T1839 9979-9981 CD denotes 1D
T1838 9978-9979 SYM denotes –
T1837 9968-9975 NNS denotes Figures
T1836 9976-9978 CD denotes 1B
T1835 9967-9968 -LRB- denotes (
T1834 9961-9966 FW denotes versa
T1833 9956-9960 FW denotes vice
T2484 12828-12829 . denotes .
T2483 12813-12824 NN denotes sensitivity
T2482 12807-12812 NN denotes taste
T2481 12802-12806 NN denotes QHCl
T2480 12796-12801 JJ denotes major
T2479 12825-12828 NN denotes QTL
T2478 12792-12795 DT denotes the
T2477 12788-12791 IN denotes for
T2476 12776-12787 JJ denotes responsible
T2475 12765-12770 NN denotes locus
T2474 12760-12764 DT denotes this
T2473 12757-12759 IN denotes at
T2472 12747-12749 CD denotes 24
T2471 12750-12756 NNS denotes Tas2rs
T2470 12743-12746 DT denotes the
T2469 12740-12742 IN denotes of
T2468 12735-12739 JJR denotes more
T2467 12732-12734 CC denotes or
T2466 12728-12731 CD denotes one
T2465 12771-12775 VBD denotes were
T2464 12723-12727 IN denotes that
T2463 12707-12709 PRP denotes we
T2462 12705-12707 , denotes ,
T2461 12687-12688 HYPH denotes -
T2460 12688-12695 VBG denotes tasting
T2459 12681-12687 JJ denotes bitter
T2458 12676-12680 DT denotes some
T2457 12696-12705 NNS denotes compounds
T1832 9952-9955 CC denotes and
T1831 9950-9952 , denotes ,
T1830 9948-9950 NN denotes DB
T1829 9945-9947 IN denotes to
T1828 9933-9944 JJ denotes insensitive
T1827 9922-9932 RB denotes relatively
T1826 9913-9917 NN denotes QHCl
T1825 9910-9912 IN denotes to
T1824 9900-9909 JJ denotes sensitive
T1823 9893-9899 RB denotes highly
T1822 9885-9892 NNS denotes strains
T1821 9880-9884 DT denotes some
T1820 9878-9880 : denotes :
T1819 9868-9870 JJ denotes RI
T1818 9871-9878 NNS denotes strains
T1817 9862-9867 DT denotes these
T1816 9855-9861 IN denotes across
T1815 9841-9854 RB denotes independently
T1814 9918-9921 VBP denotes are
T1813 9818-9823 NN denotes taste
T1812 9815-9817 NN denotes DB
T1811 9811-9814 CC denotes and
T1810 9824-9835 NN denotes sensitivity
T1809 9806-9810 NN denotes QHCl
T1808 9804-9806 , denotes ,
T1807 9836-9840 VBP denotes vary
T1806 9797-9804 RB denotes However
T1805 9796-9983 sentence denotes However, QHCl and DB taste sensitivity vary independently across these RI strains: some strains highly sensitive to QHCl are relatively insensitive to DB, and vice versa (Figures 1B–1D).
T1804 9795-9796 . denotes .
T1803 9794-9795 -RRB- denotes )
T1802 9793-9794 CD denotes 1
T1801 9785-9786 : denotes ;
T1800 9783-9785 CD denotes 1D
T1799 9782-9783 SYM denotes –
T1798 9780-9782 CD denotes 1B
T1797 9772-9779 NNS denotes Figures
T1796 9787-9792 NN denotes Table
T1795 9771-9772 -LRB- denotes (
T1794 9754-9763 JJ denotes dependent
T1793 9740-9753 NN denotes concentration
T1792 9764-9770 NN denotes manner
T1791 9738-9739 DT denotes a
T1790 9735-9737 IN denotes in
T1789 9727-9734 NNS denotes stimuli
T1788 9722-9726 DT denotes both
T1787 9704-9713 RB denotes typically
T1786 9699-9703 RB denotes also
T1785 9714-9721 VBD denotes avoided
T1784 9694-9698 NNS denotes mice
T1783 9690-9693 NN denotes BXD
T1782 9689-9796 sentence denotes BXD mice also typically avoided both stimuli in a concentration dependent manner (Figures 1B–1D; Table 1).
T1781 9688-9689 . denotes .
T1780 9677-9681 JJ denotes same
T1779 9682-9688 NN denotes manner
T1778 9673-9676 DT denotes the
T1777 9670-9672 IN denotes in
T1776 9660-9663 NN denotes BXD
T1775 9664-9669 NNS denotes lines
T1774 9657-9659 CD denotes 17
T1773 9652-9656 IN denotes from
T1772 9647-9651 NNS denotes mice
T1771 9635-9639 RB denotes next
T2158 11210-11215 NN denotes event
T2157 11186-11191 RBS denotes least
T2156 11192-11195 CD denotes one
T2155 11183-11185 RB denotes at
T2154 11174-11179 EX denotes there
T2153 11167-11173 VBN denotes tested
T2152 11158-11160 JJ denotes RI
T2151 11155-11157 CD denotes 17
T2150 11161-11166 NNS denotes lines
T2149 11151-11154 DT denotes the
T2148 11180-11182 VBZ denotes is
T2147 11144-11150 IN denotes Across
T2146 11143-11331 sentence denotes Across the 17 RI lines tested there is at least one recombination event between D6Mit13 and either D6Mit254 (and D6Mit194, the physical position of which is not well defined) or D6Mit374.
T2145 11142-11143 . denotes .
T2144 11134-11142 NN denotes D6Mit374
T2143 11127-11133 NN denotes marker
T2142 11120-11126 JJ denotes distal
T2141 11117-11119 VBZ denotes is
T2140 11114-11116 IN denotes as
T2139 11112-11114 , denotes ,
T2138 11104-11108 NN denotes QHCl
T2137 11109-11112 NN denotes QTL
T2136 11100-11103 DT denotes the
T2135 11097-11099 IN denotes to
T2134 11088-11096 JJ denotes unlinked
T2133 11075-11083 NN denotes D6Mit194
T2132 11071-11074 CC denotes and
T2131 11084-11087 VBP denotes are
T2130 11054-11061 NNS denotes markers
T2129 11045-11053 JJ denotes proximal
T2128 11062-11070 NN denotes D6Mit254
T2127 11036-11044 JJ denotes Adjacent
T2126 11035-11143 sentence denotes Adjacent proximal markers D6Mit254 and D6Mit194 are unlinked to the QHCl QTL, as is distal marker D6Mit374.
T2125 11034-11035 . denotes .
T2124 11033-11034 -RRB- denotes )
T2123 11032-11033 CD denotes 3
T2122 11023-11025 , denotes ,
T2121 11022-11023 CD denotes 2
T2120 11016-11021 NN denotes Table
T2118 11015-11016 -LRB- denotes (
T2066 10487-10488 CD denotes 3
T2065 10484-10486 IN denotes at
T2064 10482-10483 : denotes ;
T2063 10481-10482 -RRB- denotes )
T2062 10479-10481 CD denotes 2A
T2061 10472-10478 NN denotes Figure
T2060 10471-10472 -LRB- denotes (
T2059 10469-10470 CD denotes 8
T2058 10458-10468 NN denotes chromosome
T2057 10455-10457 IN denotes on
T2056 10449-10450 -RRB- denotes )
T2055 10443-10444 SYM denotes =
T2054 10441-10442 NN denotes p
T2053 10435-10436 HYPH denotes -
T2052 10436-10440 JJ denotes wide
T2051 10429-10435 NN denotes genome
T2050 10427-10428 : denotes ;
T2049 10421-10422 SYM denotes >
T2048 10423-10427 CD denotes 11.4
T2047 10417-10420 NN denotes LRS
T2046 10445-10449 CD denotes 0.65
T2045 10416-10417 -LRB- denotes (
T2044 10405-10415 JJ denotes suggestive
T2043 10403-10405 , denotes ,
T2042 10397-10403 JJ denotes second
T2041 10395-10396 DT denotes a
T2040 10451-10454 NN denotes QTL
T2039 10390-10394 IN denotes with
T2038 10388-10390 , denotes ,
T2037 10387-10388 CD denotes 6
T2036 10376-10386 NN denotes chromosome
T2035 10373-10375 IN denotes on
T2034 10516-10520 VBD denotes were
T2033 10359-10362 VBD denotes was
T2032 10354-10358 NN denotes QHCl
T2031 10351-10353 NN denotes mM
T2030 10349-10350 CD denotes 1
T2029 10346-10348 IN denotes to
T2028 10334-10345 NN denotes sensitivity
T2027 10330-10333 IN denotes for
T2026 10363-10372 VBN denotes indicated
T2025 10324-10325 -RRB- denotes )
T2024 10318-10319 SYM denotes =
T2023 10316-10317 NN denotes p
T2022 10310-10311 HYPH denotes -
T2021 10311-10315 JJ denotes wide
T2020 10304-10310 NN denotes genome
T2019 10302-10303 : denotes ;
T2018 10296-10297 SYM denotes >
T2017 10298-10302 CD denotes 20.5
T2016 10292-10295 NN denotes LRS
T2015 10320-10324 CD denotes 0.05
T2014 10291-10292 -LRB- denotes (
T2013 10279-10290 JJ denotes significant
T2012 10326-10329 NN denotes QTL
T2011 10277-10278 DT denotes A
T2010 10276-10600 sentence denotes A significant (LRS > 20.5; genome-wide p = 0.05) QTL for sensitivity to 1 mM QHCl was indicated on chromosome 6, with a second, suggestive (LRS > 11.4; genome-wide p = 0.65) QTL on chromosome 8 (Figure 2A); at 3 mM QHCl, both of these QTL were suggestive (LRS > 10.9) but did not reach genome-wide significance (Figure 2B).
T2009 10275-10276 . denotes .
T2008 10274-10275 -RRB- denotes )
T2007 10273-10274 CD denotes 1
T2006 10268-10272 NN denotes File
T2005 10257-10267 JJ denotes Additional
T2004 10251-10252 : denotes ;
T2003 10245-10246 SYM denotes =
T2002 10247-10251 CD denotes 0.65
T2001 10243-10244 NN denotes p
T2000 10237-10238 HYPH denotes -
T1999 10238-10242 JJ denotes wide
T1998 10231-10237 NN denotes genome
T1997 10229-10231 , denotes ,
T1996 10224-10225 SYM denotes >
T1995 10226-10229 CD denotes 9.4
T1994 10220-10223 NN denotes LRS
T1993 10253-10256 VB denotes see
T1992 10219-10220 -LRB- denotes (
T1991 10217-10218 '' denotes "
T1990 10207-10217 JJ denotes suggestive
T1989 10206-10207 `` denotes "
T1988 10198-10200 CD denotes 12
T1987 10194-10197 CC denotes and
T1986 10192-10193 CD denotes 8
T1985 10191-10192 , denotes ,
T1984 10190-10191 CD denotes 2
T1983 10178-10189 NNS denotes chromosomes
T1982 10175-10177 IN denotes on
T1981 10167-10174 NNS denotes markers
T1980 10162-10166 IN denotes with
T1979 10149-10161 NNS denotes associations
T1978 10141-10148 JJ denotes several
T1977 10201-10205 VBD denotes were
T1976 10132-10140 IN denotes although
T1975 10130-10132 , denotes ,
T1974 10113-10118 NN denotes taste
T1973 10119-10130 NN denotes sensitivity
T1972 10110-10112 NN denotes DB
T1971 10106-10109 IN denotes for
T1970 10090-10094 VBD denotes were
T1969 10095-10105 VBN denotes identified
T2240 11615-11623 NN denotes genotype
T2239 11610-11611 DT denotes a
T2238 11605-11609 VBP denotes have
T2237 11601-11604 CC denotes but
T2236 11599-11601 , denotes ,
T2235 11592-11599 NN denotes D6Mit13
T2234 11588-11591 IN denotes for
T2233 11579-11587 NN denotes genotype
T2232 11576-11578 NN denotes D2
T2231 11572-11575 CC denotes and
T2230 11570-11571 -RRB- denotes )
T2229 11568-11570 CD denotes 1C
T2228 11561-11567 NN denotes Figure
T2227 11560-11561 -LRB- denotes (
T2226 11554-11559 NN denotes taste
T2225 11549-11553 NN denotes QHCl
T2224 11545-11548 IN denotes for
T2223 11532-11534 NN denotes D2
T2222 11526-11531 JJ denotes clear
T2221 11535-11544 NN denotes phenotype
T2220 11524-11525 DT denotes a
T2219 11516-11523 VBP denotes display
T2218 11508-11510 JJ denotes RI
T2217 11505-11507 CD denotes 34
T2216 11504-11505 HYPH denotes -
T2215 11502-11504 NN denotes Ty
T2214 11501-11502 HYPH denotes /
T2213 11511-11515 NNS denotes mice
T2212 11498-11501 NN denotes BXD
T2211 11497-11697 sentence denotes BXD/Ty-34 RI mice display a clear D2 phenotype for QHCl taste (Figure 1C) and D2 genotype for D6Mit13, but have a B6 genotype for D6Mit61 [39,40], indicating that D6Mit61 is unlinked to the QHCl QTL.
T2210 11496-11497 . denotes .
T2209 11476-11483 NNP denotes Jackson
T2208 11484-11496 NNP denotes Laboratories
T2207 11472-11475 DT denotes the
T2206 11469-11471 IN denotes by
T2205 11460-11468 VBN denotes reported
T2204 11450-11453 NN denotes BXD
T2203 11454-11459 NNS denotes lines
T2202 11446-11449 DT denotes the
T2201 11443-11445 IN denotes of
T2200 11433-11442 NNS denotes genotypes
T2199 11428-11432 IN denotes from
T2198 11413-11416 VBD denotes was
T2197 11411-11413 , denotes ,
T2196 11404-11411 NN denotes D6Mit13
T2195 11400-11403 CC denotes and
T2194 11391-11399 NN denotes D6Mit194
T2193 11383-11390 IN denotes between
T2192 11378-11382 VBZ denotes lies
T2191 11372-11377 WDT denotes which
T2190 11370-11372 , denotes ,
T2189 11363-11370 NN denotes D6Mit61
T2188 11361-11363 , denotes ,
T2187 11417-11427 VBN denotes identified
T2186 11346-11354 JJ denotes proximal
T2185 11335-11345 JJ denotes additional
T2184 11355-11361 NN denotes marker
T2183 11332-11334 DT denotes An
T2182 11331-11497 sentence denotes An additional proximal marker, D6Mit61, which lies between D6Mit194 and D6Mit13, was identified from genotypes of the BXD lines reported by the Jackson Laboratories.
T2181 11330-11331 . denotes .
T2180 11322-11330 NN denotes D6Mit374
T2179 11319-11321 CC denotes or
T2178 11317-11318 -RRB- denotes )
T2177 11310-11317 JJ denotes defined
T2176 11305-11309 RB denotes well
T2175 11301-11304 RB denotes not
T2174 11292-11297 WDT denotes which
T2173 11289-11291 IN denotes of
T2172 11298-11300 VBZ denotes is
T2171 11271-11279 JJ denotes physical
T2170 11280-11288 NN denotes position
T2169 11267-11270 DT denotes the
T2168 11265-11267 , denotes ,
T2167 11257-11265 NN denotes D6Mit194
T2166 11253-11256 CC denotes and
T2165 11252-11253 -LRB- denotes (
T2164 11243-11251 NN denotes D6Mit254
T2163 11236-11242 CC denotes either
T2162 11232-11235 CC denotes and
T2161 11224-11231 NN denotes D6Mit13
T2160 11216-11223 IN denotes between
T2159 11196-11209 NN denotes recombination
T126 53-57 VBP denotes vary
T127 0-103 sentence denotes Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice
T128 11-13 IN denotes at
T129 14-17 DT denotes the
T130 24-29 NN denotes locus
T131 18-23 NN denotes Tas2r
T132 30-32 IN denotes on
T133 33-39 JJ denotes distal
T134 40-50 NN denotes chromosome
T135 51-52 CD denotes 6
T136 58-62 IN denotes with
T137 63-70 NN denotes quinine
T138 71-76 NN denotes taste
T139 77-88 NN denotes sensitivity
T140 89-91 IN denotes in
T141 92-98 JJ denotes inbred
T142 99-103 NNS denotes mice
T143 103-104 sentence denotes
T144 114-124 sentence denotes Background
T145 114-124 NN denotes Background
T146 124-261 sentence denotes The detection of bitter-tasting compounds by the gustatory system is thought to alert animals to the presence of potentially toxic food.
T147 125-128 DT denotes The
T148 129-138 NN denotes detection
T149 194-201 VBN denotes thought
T150 139-141 IN denotes of
T151 142-148 JJ denotes bitter
T152 149-156 VBG denotes tasting
T153 148-149 HYPH denotes -
T154 157-166 NNS denotes compounds
T155 167-169 IN denotes by
T156 170-173 DT denotes the
T157 184-190 NN denotes system
T158 174-183 JJ denotes gustatory
T159 191-193 VBZ denotes is
T160 202-204 TO denotes to
T161 205-210 VB denotes alert
T162 211-218 NNS denotes animals
T163 219-221 IN denotes to
T164 222-225 DT denotes the
T165 226-234 NN denotes presence
T166 235-237 IN denotes of
T167 238-249 RB denotes potentially
T168 250-255 JJ denotes toxic
T169 256-260 NN denotes food
T170 260-261 . denotes .
T171 261-420 sentence denotes Some, if not all, bitter stimuli activate specific taste receptors, the T2Rs, which are expressed in subsets of taste receptor cells on the tongue and palate.
T172 262-266 DT denotes Some
T173 295-303 VBP denotes activate
T174 266-268 , denotes ,
T175 268-270 IN denotes if
T176 271-274 RB denotes not
T177 275-278 DT denotes all
T178 278-280 , denotes ,
T179 280-286 JJ denotes bitter
T180 287-294 NNS denotes stimuli
T181 304-312 JJ denotes specific
T182 319-328 NNS denotes receptors
T183 313-318 NN denotes taste
T184 328-330 , denotes ,
T185 330-333 DT denotes the
T186 334-338 NNS denotes T2Rs
T187 338-340 , denotes ,
T188 340-345 WDT denotes which
T189 350-359 VBN denotes expressed
T190 346-349 VBP denotes are
T191 360-362 IN denotes in
T192 363-370 NNS denotes subsets
T193 371-373 IN denotes of
T194 374-379 NN denotes taste
T195 389-394 NNS denotes cells
T196 380-388 NN denotes receptor
T197 395-397 IN denotes on
T198 398-401 DT denotes the
T199 402-408 NN denotes tongue
T200 409-412 CC denotes and
T201 413-419 NN denotes palate
T202 419-420 . denotes .
T203 420-617 sentence denotes However, there is evidence for both receptor-dependent and -independent transduction mechanisms for a number of bitter stimuli, including quinine hydrochloride (QHCl) and denatonium benzoate (DB).
T204 421-428 RB denotes However
T205 436-438 VBZ denotes is
T206 428-430 , denotes ,
T207 430-435 EX denotes there
T208 439-447 NN denotes evidence
T209 448-451 IN denotes for
T210 452-456 CC denotes both
T211 506-516 NNS denotes mechanisms
T212 457-465 NN denotes receptor
T213 466-475 JJ denotes dependent
T214 465-466 HYPH denotes -
T215 476-479 CC denotes and
T216 480-481 HYPH denotes -
T217 481-492 JJ denotes independent
T218 493-505 NN denotes transduction
T219 517-520 IN denotes for
T220 521-522 DT denotes a
T221 523-529 NN denotes number
T222 530-532 IN denotes of
T223 533-539 JJ denotes bitter
T224 540-547 NNS denotes stimuli
T225 547-549 , denotes ,
T226 549-558 VBG denotes including
T227 559-566 NN denotes quinine
T228 567-580 NN denotes hydrochloride
T229 581-582 -LRB- denotes (
T230 582-586 NN denotes QHCl
T231 586-587 -RRB- denotes )
T232 588-591 CC denotes and
T233 592-602 NN denotes denatonium
T234 603-611 NN denotes benzoate
T235 612-613 -LRB- denotes (
T236 613-615 NN denotes DB
T237 615-616 -RRB- denotes )
T238 616-617 . denotes .
T239 617-626 sentence denotes Results
T240 619-626 NNS denotes Results
T241 626-799 sentence denotes We used brief-access behavioral taste testing of BXD/Ty recombinant inbred (RI) mouse strains to map the major quantitative trait locus (QTL) for taste sensitivity to QHCl.
T242 627-629 PRP denotes We
T243 630-634 VBD denotes used
T244 635-640 JJ denotes brief
T245 641-647 NN denotes access
T246 640-641 HYPH denotes -
T247 665-672 NN denotes testing
T248 648-658 JJ denotes behavioral
T249 659-664 NN denotes taste
T250 673-675 IN denotes of
T251 676-679 NN denotes BXD
T252 680-682 NN denotes Ty
T253 679-680 HYPH denotes /
T254 713-720 NNS denotes strains
T255 683-694 JJ denotes recombinant
T256 695-701 JJ denotes inbred
T257 702-703 -LRB- denotes (
T258 703-705 JJ denotes RI
T259 705-706 -RRB- denotes )
T260 707-712 NN denotes mouse
T261 721-723 TO denotes to
T262 724-727 VB denotes map
T263 728-731 DT denotes the
T264 757-762 NN denotes locus
T265 732-737 JJ denotes major
T266 738-750 JJ denotes quantitative
T267 751-756 NN denotes trait
T268 763-764 -LRB- denotes (
T269 764-767 NN denotes QTL
T270 767-768 -RRB- denotes )
T271 769-772 IN denotes for
T272 773-778 NN denotes taste
T273 779-790 NN denotes sensitivity
T274 791-793 IN denotes to
T275 794-798 NN denotes QHCl
T276 798-799 . denotes .
T277 799-905 sentence denotes This QTL is restricted to a ~5 Mb interval on chromosome 6 that includes 24 genes encoding T2Rs (Tas2rs).
T278 800-804 DT denotes This
T279 805-808 NN denotes QTL
T280 812-822 VBN denotes restricted
T281 809-811 VBZ denotes is
T282 823-825 IN denotes to
T283 826-827 DT denotes a
T284 834-842 NN denotes interval
T285 828-829 SYM denotes ~
T286 829-830 CD denotes 5
T287 831-833 NN denotes Mb
T288 843-845 IN denotes on
T289 846-856 NN denotes chromosome
T290 857-858 CD denotes 6
T291 859-863 WDT denotes that
T292 864-872 VBZ denotes includes
T293 873-875 CD denotes 24
T294 876-881 NNS denotes genes
T295 882-890 VBG denotes encoding
T296 891-895 NNS denotes T2Rs
T297 896-897 -LRB- denotes (
T298 897-903 NNS denotes Tas2rs
T299 903-904 -RRB- denotes )
T300 904-905 . denotes .
T301 905-1156 sentence denotes Tas2rs at this locus display in total 307 coding region single nucleotide polymorphisms (SNPs) between the two BXD/Ty RI parental strains, C57BL/6J (quinine-sensitive) and DBA/2J (quinine insensitive); approximately 50% of these mutations are silent.
T302 906-912 NNS denotes Tas2rs
T303 927-934 VBP denotes display
T304 913-915 IN denotes at
T305 916-920 DT denotes this
T306 921-926 NN denotes locus
T307 1145-1148 VBP denotes are
T308 935-937 IN denotes in
T309 938-943 JJ denotes total
T310 944-947 CD denotes 307
T311 980-993 NNS denotes polymorphisms
T312 948-954 NN denotes coding
T313 955-961 NN denotes region
T314 962-968 JJ denotes single
T315 969-979 NN denotes nucleotide
T316 994-995 -LRB- denotes (
T317 995-999 NNS denotes SNPs
T318 999-1000 -RRB- denotes )
T319 1001-1008 IN denotes between
T320 1009-1012 DT denotes the
T321 1036-1043 NNS denotes strains
T322 1013-1016 CD denotes two
T323 1017-1020 NN denotes BXD
T324 1021-1023 NN denotes Ty
T325 1020-1021 HYPH denotes /
T326 1024-1026 JJ denotes RI
T327 1027-1035 JJ denotes parental
T328 1043-1045 , denotes ,
T329 1045-1050 NN denotes C57BL
T330 1051-1053 NN denotes 6J
T331 1050-1051 HYPH denotes /
T332 1054-1055 -LRB- denotes (
T333 1063-1072 JJ denotes sensitive
T334 1055-1062 NN denotes quinine
T335 1062-1063 HYPH denotes -
T336 1072-1073 -RRB- denotes )
T337 1074-1077 CC denotes and
T338 1078-1081 NN denotes DBA
T339 1082-1084 NN denotes 2J
T340 1081-1082 HYPH denotes /
T341 1085-1086 -LRB- denotes (
T342 1094-1105 JJ denotes insensitive
T343 1086-1093 NN denotes quinine
T344 1105-1106 -RRB- denotes )
T345 1106-1107 : denotes ;
T346 1108-1121 RB denotes approximately
T347 1122-1124 CD denotes 50
T348 1124-1125 NN denotes %
T349 1126-1128 IN denotes of
T350 1129-1134 DT denotes these
T351 1135-1144 NNS denotes mutations
T352 1149-1155 JJ denotes silent
T353 1155-1156 . denotes .
T354 1156-1367 sentence denotes Individual RI lines contain exclusively either C57BL/6J or DBA/2J Tas2r alleles at this locus, and RI lines containing C57BL/6J Tas2r alleles are more sensitive to QHCl than are lines containing DBA/2J alleles.
T355 1157-1167 JJ denotes Individual
T356 1171-1176 NNS denotes lines
T357 1168-1170 JJ denotes RI
T358 1177-1184 VBP denotes contain
T359 1185-1196 RB denotes exclusively
T360 1197-1203 CC denotes either
T361 1210-1212 NN denotes 6J
T362 1204-1209 NN denotes C57BL
T363 1209-1210 HYPH denotes /
T364 1229-1236 NNS denotes alleles
T365 1213-1215 CC denotes or
T366 1216-1219 NN denotes DBA
T367 1220-1222 NN denotes 2J
T368 1219-1220 HYPH denotes /
T369 1223-1228 NN denotes Tas2r
T370 1237-1239 IN denotes at
T371 1240-1244 DT denotes this
T372 1245-1250 NN denotes locus
T373 1250-1252 , denotes ,
T374 1252-1255 CC denotes and
T375 1256-1258 JJ denotes RI
T376 1259-1264 NNS denotes lines
T377 1299-1302 VBP denotes are
T378 1265-1275 VBG denotes containing
T379 1276-1281 NN denotes C57BL
T380 1282-1284 NN denotes 6J
T381 1281-1282 HYPH denotes /
T382 1291-1298 NNS denotes alleles
T383 1285-1290 NN denotes Tas2r
T384 1303-1307 RBR denotes more
T385 1308-1317 JJ denotes sensitive
T386 1318-1320 IN denotes to
T387 1321-1325 NN denotes QHCl
T388 1326-1330 IN denotes than
T389 1331-1334 VBP denotes are
T390 1335-1340 NNS denotes lines
T391 1341-1351 VBG denotes containing
T392 1352-1355 NN denotes DBA
T393 1356-1358 NN denotes 2J
T394 1355-1356 HYPH denotes /
T395 1359-1366 NNS denotes alleles
T396 1366-1367 . denotes .
T397 1367-1470 sentence denotes Thus, the entire Tas2r cluster comprises a large haplotype that correlates with quinine taster status.
T398 1368-1372 RB denotes Thus
T399 1399-1408 VBZ denotes comprises
T400 1372-1374 , denotes ,
T401 1374-1377 DT denotes the
T402 1391-1398 NN denotes cluster
T403 1378-1384 JJ denotes entire
T404 1385-1390 NN denotes Tas2r
T405 1409-1410 DT denotes a
T406 1417-1426 NN denotes haplotype
T407 1411-1416 JJ denotes large
T408 1427-1431 WDT denotes that
T409 1432-1442 VBZ denotes correlates
T410 1443-1447 IN denotes with
T411 1448-1455 NN denotes quinine
T412 1456-1462 NN denotes taster
T413 1463-1469 NN denotes status
T414 1469-1470 . denotes .
T415 1470-1482 sentence denotes Conclusion
T416 1472-1482 NN denotes Conclusion
T417 1482-1707 sentence denotes These studies, the first using a taste-salient assay to map the major QTL for quinine taste, indicate that a T2R-dependent transduction cascade is responsible for the majority of strain variance in quinine taste sensitivity.
T418 1483-1488 DT denotes These
T419 1489-1496 NNS denotes studies
T420 1576-1584 VBP denotes indicate
T421 1496-1498 , denotes ,
T422 1498-1501 DT denotes the
T423 1502-1507 JJ denotes first
T424 1508-1513 VBG denotes using
T425 1514-1515 DT denotes a
T426 1530-1535 NN denotes assay
T427 1516-1521 NN denotes taste
T428 1522-1529 JJ denotes salient
T429 1521-1522 HYPH denotes -
T430 1536-1538 TO denotes to
T431 1539-1542 VB denotes map
T432 1543-1546 DT denotes the
T433 1553-1556 NN denotes QTL
T434 1547-1552 JJ denotes major
T435 1557-1560 IN denotes for
T436 1561-1568 NN denotes quinine
T437 1569-1574 NN denotes taste
T438 1574-1576 , denotes ,
T439 1585-1589 IN denotes that
T440 1627-1629 VBZ denotes is
T441 1590-1591 DT denotes a
T442 1619-1626 NN denotes cascade
T443 1592-1595 NN denotes T2R
T444 1596-1605 JJ denotes dependent
T445 1595-1596 HYPH denotes -
T446 1606-1618 NN denotes transduction
T447 1630-1641 JJ denotes responsible
T448 1642-1645 IN denotes for
T449 1646-1649 DT denotes the
T450 1650-1658 NN denotes majority
T451 1659-1661 IN denotes of
T452 1662-1668 NN denotes strain
T453 1669-1677 NN denotes variance
T454 1678-1680 IN denotes in
T455 1681-1688 NN denotes quinine
T456 1689-1694 NN denotes taste
T457 1695-1706 NN denotes sensitivity
T458 1706-1707 . denotes .
T459 1707-1947 sentence denotes Furthermore, the large number of polymorphisms within coding exons of the Tas2r cluster, coupled with evidence that inbred strains exhibit largely similar bitter taste phenotypes, suggest that T2R receptors are quite tolerant to variation.
T460 1708-1719 RB denotes Furthermore
T461 1888-1895 VBP denotes suggest
T462 1719-1721 , denotes ,
T463 1721-1724 DT denotes the
T464 1731-1737 NN denotes number
T465 1725-1730 JJ denotes large
T466 1738-1740 IN denotes of
T467 1741-1754 NNS denotes polymorphisms
T468 1755-1761 IN denotes within
T469 1762-1768 VBG denotes coding
T470 1769-1774 NNS denotes exons
T471 1775-1777 IN denotes of
T472 1778-1781 DT denotes the
T473 1788-1795 NN denotes cluster
T474 1782-1787 NN denotes Tas2r
T475 1795-1797 , denotes ,
T476 1797-1804 VBN denotes coupled
T477 1805-1809 IN denotes with
T478 1810-1818 NN denotes evidence
T479 1819-1823 IN denotes that
T480 1839-1846 VBP denotes exhibit
T481 1824-1830 JJ denotes inbred
T482 1831-1838 NNS denotes strains
T483 1847-1854 RB denotes largely
T484 1855-1862 JJ denotes similar
T485 1876-1886 NNS denotes phenotypes
T486 1863-1869 JJ denotes bitter
T487 1870-1875 NN denotes taste
T488 1886-1888 , denotes ,
T489 1896-1900 IN denotes that
T490 1915-1918 VBP denotes are
T491 1901-1904 NN denotes T2R
T492 1905-1914 NNS denotes receptors
T493 1919-1924 RB denotes quite
T494 1925-1933 JJ denotes tolerant
T495 1934-1936 IN denotes to
T496 1937-1946 NN denotes variation
T497 1946-1947 . denotes .
T726 1960-1967 NNS denotes Animals
T727 1968-1971 VBP denotes use
T728 1972-1975 DT denotes the
T729 1986-1992 NN denotes system
T730 1976-1985 JJ denotes gustatory
T731 1993-1995 TO denotes to
T732 1996-2003 VB denotes provide
T733 2004-2015 NN denotes information
T734 2016-2021 IN denotes about
T735 2022-2026 NN denotes food
T736 2027-2034 NN denotes quality
T737 2034-2035 . denotes .
T738 2035-2205 sentence denotes For example, sweet-tasting foods may have a high caloric content and are preferred, while bitter-tasting foods often contain toxic substances, and are generally avoided.
T739 2036-2039 IN denotes For
T740 2073-2077 VB denotes have
T741 2040-2047 NN denotes example
T742 2047-2049 , denotes ,
T743 2049-2054 JJ denotes sweet
T744 2055-2062 VBG denotes tasting
T745 2054-2055 HYPH denotes -
T746 2063-2068 NNS denotes foods
T747 2069-2072 MD denotes may
T748 2078-2079 DT denotes a
T749 2093-2100 NN denotes content
T750 2080-2084 JJ denotes high
T751 2085-2092 JJ denotes caloric
T752 2101-2104 CC denotes and
T753 2105-2108 VBP denotes are
T754 2109-2118 VBN denotes preferred
T755 2118-2120 , denotes ,
T756 2120-2125 IN denotes while
T757 2153-2160 VBP denotes contain
T758 2126-2132 JJ denotes bitter
T759 2133-2140 VBG denotes tasting
T760 2132-2133 HYPH denotes -
T761 2141-2146 NNS denotes foods
T762 2147-2152 RB denotes often
T763 2161-2166 JJ denotes toxic
T764 2167-2177 NNS denotes substances
T765 2177-2179 , denotes ,
T766 2179-2182 CC denotes and
T767 2183-2186 VBP denotes are
T768 2197-2204 VBN denotes avoided
T769 2187-2196 RB denotes generally
T770 2204-2205 . denotes .
T771 2205-2545 sentence denotes Two families of G protein-coupled receptors (GPCRs) expressed in subpopulations of taste receptor cells (TRCs) of the gustatory epithelium have been implicated in the detection and transduction of sweet, bitter and umami (i.e., glutamate) taste: T1Rs for sweet-and umami-tasting stimuli [1-8], and T2Rs for bitter-tasting compounds [9-11].
T772 2206-2209 CD denotes Two
T773 2210-2218 NNS denotes families
T774 2355-2365 VBN denotes implicated
T775 2219-2221 IN denotes of
T776 2222-2223 NN denotes G
T777 2224-2231 NN denotes protein
T778 2232-2239 VBN denotes coupled
T779 2231-2232 HYPH denotes -
T780 2240-2249 NNS denotes receptors
T781 2250-2251 -LRB- denotes (
T782 2251-2256 NNS denotes GPCRs
T783 2256-2257 -RRB- denotes )
T784 2258-2267 VBN denotes expressed
T785 2268-2270 IN denotes in
T786 2271-2285 NNS denotes subpopulations
T787 2286-2288 IN denotes of
T788 2289-2294 NN denotes taste
T789 2304-2309 NNS denotes cells
T790 2295-2303 NN denotes receptor
T791 2310-2311 -LRB- denotes (
T792 2311-2315 NNS denotes TRCs
T793 2315-2316 -RRB- denotes )
T794 2317-2319 IN denotes of
T795 2320-2323 DT denotes the
T796 2334-2344 NN denotes epithelium
T797 2324-2333 JJ denotes gustatory
T798 2345-2349 VBP denotes have
T799 2350-2354 VBN denotes been
T800 2366-2368 IN denotes in
T801 2369-2372 DT denotes the
T802 2373-2382 NN denotes detection
T803 2383-2386 CC denotes and
T804 2387-2399 NN denotes transduction
T805 2400-2402 IN denotes of
T806 2403-2408 JJ denotes sweet
T807 2445-2450 NN denotes taste
T808 2408-2410 , denotes ,
T809 2410-2416 JJ denotes bitter
T810 2417-2420 CC denotes and
T811 2421-2426 NN denotes umami
T812 2427-2428 -LRB- denotes (
T813 2434-2443 NN denotes glutamate
T814 2428-2432 FW denotes i.e.
T815 2432-2434 , denotes ,
T816 2443-2444 -RRB- denotes )
T817 2450-2452 : denotes :
T818 2452-2456 NNS denotes T1Rs
T819 2457-2460 IN denotes for
T820 2461-2466 JJ denotes sweet
T821 2485-2492 NNS denotes stimuli
T822 2466-2467 HYPH denotes -
T823 2467-2470 CC denotes and
T824 2471-2476 JJ denotes umami
T825 2477-2484 VBG denotes tasting
T826 2476-2477 HYPH denotes -
T827 2493-2494 -LRB- denotes [
T828 2494-2495 CD denotes 1
T829 2495-2496 SYM denotes -
T830 2496-2497 CD denotes 8
T831 2497-2498 -RRB- denotes ]
T832 2498-2500 , denotes ,
T833 2500-2503 CC denotes and
T834 2504-2508 NNS denotes T2Rs
T835 2509-2512 IN denotes for
T836 2513-2519 JJ denotes bitter
T837 2520-2527 VBG denotes tasting
T838 2519-2520 HYPH denotes -
T839 2528-2537 NNS denotes compounds
T840 2538-2539 -LRB- denotes [
T841 2539-2540 CD denotes 9
T842 2540-2541 SYM denotes -
T843 2541-2543 CD denotes 11
T844 2543-2544 -RRB- denotes ]
T845 2544-2545 . denotes .
T846 2545-2744 sentence denotes The genes that encode T2Rs, the Tas2rs, were first identified by database mining of mammalian genomes near chromosomal markers previously linked to differences in bitter taste sensitivity [9,11-18].
T847 2546-2549 DT denotes The
T848 2550-2555 NNS denotes genes
T849 2597-2607 VBN denotes identified
T850 2556-2560 WDT denotes that
T851 2561-2567 VBP denotes encode
T852 2568-2572 NNS denotes T2Rs
T853 2572-2574 , denotes ,
T854 2574-2577 DT denotes the
T855 2578-2584 NNS denotes Tas2rs
T856 2584-2586 , denotes ,
T857 2586-2590 VBD denotes were
T858 2591-2596 RB denotes first
T859 2608-2610 IN denotes by
T860 2611-2619 NN denotes database
T861 2620-2626 NN denotes mining
T862 2627-2629 IN denotes of
T863 2630-2639 JJ denotes mammalian
T864 2640-2647 NNS denotes genomes
T865 2648-2652 IN denotes near
T866 2653-2664 JJ denotes chromosomal
T867 2665-2672 NNS denotes markers
T868 2673-2683 RB denotes previously
T869 2684-2690 VBN denotes linked
T870 2691-2693 IN denotes to
T871 2694-2705 NNS denotes differences
T872 2706-2708 IN denotes in
T873 2709-2715 JJ denotes bitter
T874 2716-2721 NN denotes taste
T875 2722-2733 NN denotes sensitivity
T876 2734-2735 -LRB- denotes [
T877 2737-2739 CD denotes 11
T878 2735-2736 CD denotes 9
T879 2736-2737 , denotes ,
T880 2739-2740 SYM denotes -
T881 2740-2742 CD denotes 18
T882 2742-2743 -RRB- denotes ]
T883 2743-2744 . denotes .
T884 2744-2828 sentence denotes In mice, the majority of Tas2rs lie within a single cluster on distal chromosome 6.
T885 2745-2747 IN denotes In
T886 2777-2780 VBP denotes lie
T887 2748-2752 NNS denotes mice
T888 2752-2754 , denotes ,
T889 2754-2757 DT denotes the
T890 2758-2766 NN denotes majority
T891 2767-2769 IN denotes of
T892 2770-2776 NNS denotes Tas2rs
T893 2781-2787 IN denotes within
T894 2788-2789 DT denotes a
T895 2797-2804 NN denotes cluster
T896 2790-2796 JJ denotes single
T897 2805-2807 IN denotes on
T898 2808-2814 JJ denotes distal
T899 2815-2825 NN denotes chromosome
T900 2826-2827 CD denotes 6
T901 2827-2828 . denotes .
T902 2828-3183 sentence denotes Thirty-three human Tas2rs (including 8 pseudogenes) and thirty-six mouse Tas2rs (including 3 pseudogenes in C57BL/6J mice) have been identified [9,11,19], and several of these respond to particular bitter stimuli in heterologous expression assays [10,20-23], or represent a strong candidate gene for a specific bitter taste quantitative trait [18,24,25].
T903 2829-2835 CD denotes Thirty
T904 2836-2841 CD denotes three
T905 2835-2836 HYPH denotes -
T906 2848-2854 NNS denotes Tas2rs
T907 2842-2847 JJ denotes human
T908 2962-2972 VBN denotes identified
T909 2855-2856 -LRB- denotes (
T910 2856-2865 VBG denotes including
T911 2866-2867 CD denotes 8
T912 2868-2879 NNS denotes pseudogenes
T913 2879-2880 -RRB- denotes )
T914 2881-2884 CC denotes and
T915 2885-2891 CD denotes thirty
T916 2892-2895 CD denotes six
T917 2891-2892 HYPH denotes -
T918 2902-2908 NNS denotes Tas2rs
T919 2896-2901 NN denotes mouse
T920 2909-2910 -LRB- denotes (
T921 2910-2919 VBG denotes including
T922 2920-2921 CD denotes 3
T923 2922-2933 NNS denotes pseudogenes
T924 2934-2936 IN denotes in
T925 2937-2942 NN denotes C57BL
T926 2943-2945 NN denotes 6J
T927 2942-2943 HYPH denotes /
T928 2946-2950 NNS denotes mice
T929 2950-2951 -RRB- denotes )
T930 2952-2956 VBP denotes have
T931 2957-2961 VBN denotes been
T932 2973-2974 -LRB- denotes [
T933 2979-2981 CD denotes 19
T934 2974-2975 CD denotes 9
T935 2975-2976 , denotes ,
T936 2976-2978 CD denotes 11
T937 2978-2979 , denotes ,
T938 2981-2982 -RRB- denotes ]
T939 2982-2984 , denotes ,
T940 2984-2987 CC denotes and
T941 2988-2995 JJ denotes several
T942 3005-3012 VBP denotes respond
T943 2996-2998 IN denotes of
T944 2999-3004 DT denotes these
T945 3013-3015 IN denotes to
T946 3016-3026 JJ denotes particular
T947 3034-3041 NNS denotes stimuli
T948 3027-3033 JJ denotes bitter
T949 3042-3044 IN denotes in
T950 3045-3057 JJ denotes heterologous
T951 3069-3075 NNS denotes assays
T952 3058-3068 NN denotes expression
T953 3076-3077 -LRB- denotes [
T954 3080-3082 CD denotes 20
T955 3077-3079 CD denotes 10
T956 3079-3080 , denotes ,
T957 3082-3083 SYM denotes -
T958 3083-3085 CD denotes 23
T959 3085-3086 -RRB- denotes ]
T960 3086-3088 , denotes ,
T961 3088-3090 CC denotes or
T962 3091-3100 VBP denotes represent
T963 3101-3102 DT denotes a
T964 3120-3124 NN denotes gene
T965 3103-3109 JJ denotes strong
T966 3110-3119 NN denotes candidate
T967 3125-3128 IN denotes for
T968 3129-3130 DT denotes a
T969 3166-3171 NN denotes trait
T970 3131-3139 JJ denotes specific
T971 3140-3146 JJ denotes bitter
T972 3147-3152 NN denotes taste
T973 3153-3165 JJ denotes quantitative
T974 3172-3173 -LRB- denotes [
T975 3179-3181 CD denotes 25
T976 3173-3175 CD denotes 18
T977 3175-3176 , denotes ,
T978 3176-3178 CD denotes 24
T979 3178-3179 , denotes ,
T980 3181-3182 -RRB- denotes ]
T981 3182-3183 . denotes .
T982 3183-3431 sentence denotes Several quantitative trait loci (QTL) have been identified that influence two-bottle intake of bitter stimuli in the mouse, including loci for quinine (Qui) [12,16,26], cyclohexamide (Cyx) [13] and sucrose octaacetate (Soa) [14,15,17] sensitivity.
T983 3184-3191 JJ denotes Several
T984 3211-3215 NNS denotes loci
T985 3192-3204 JJ denotes quantitative
T986 3205-3210 NN denotes trait
T987 3232-3242 VBN denotes identified
T988 3216-3217 -LRB- denotes (
T989 3217-3220 NN denotes QTL
T990 3220-3221 -RRB- denotes )
T991 3222-3226 VBP denotes have
T992 3227-3231 VBN denotes been
T993 3243-3247 WDT denotes that
T994 3248-3257 VBP denotes influence
T995 3258-3261 CD denotes two
T996 3262-3268 NN denotes bottle
T997 3261-3262 HYPH denotes -
T998 3269-3275 NN denotes intake
T999 3276-3278 IN denotes of
T1000 3279-3285 JJ denotes bitter
T1001 3286-3293 NNS denotes stimuli
T1002 3294-3296 IN denotes in
T1003 3297-3300 DT denotes the
T1004 3301-3306 NN denotes mouse
T1005 3306-3308 , denotes ,
T1006 3308-3317 VBG denotes including
T1007 3318-3322 NNS denotes loci
T1008 3323-3326 IN denotes for
T1009 3327-3334 NN denotes quinine
T1010 3419-3430 NN denotes sensitivity
T1011 3335-3336 -LRB- denotes (
T1012 3336-3339 NN denotes Qui
T1013 3339-3340 -RRB- denotes )
T1014 3341-3342 -LRB- denotes [
T1015 3348-3350 CD denotes 26
T1016 3342-3344 CD denotes 12
T1017 3344-3345 , denotes ,
T1018 3345-3347 CD denotes 16
T1019 3347-3348 , denotes ,
T1020 3350-3351 -RRB- denotes ]
T1021 3351-3353 , denotes ,
T1022 3353-3366 NN denotes cyclohexamide
T1023 3367-3368 -LRB- denotes (
T1024 3368-3371 NN denotes Cyx
T1025 3371-3372 -RRB- denotes )
T1026 3373-3374 -LRB- denotes [
T1027 3374-3376 CD denotes 13
T1028 3376-3377 -RRB- denotes ]
T1029 3378-3381 CC denotes and
T1030 3382-3389 NN denotes sucrose
T1031 3390-3401 NN denotes octaacetate
T1032 3402-3403 -LRB- denotes (
T1033 3403-3406 NN denotes Soa
T1034 3406-3407 -RRB- denotes )
T1035 3408-3409 -LRB- denotes [
T1036 3415-3417 CD denotes 17
T1037 3409-3411 CD denotes 14
T1038 3411-3412 , denotes ,
T1039 3412-3414 CD denotes 15
T1040 3414-3415 , denotes ,
T1041 3417-3418 -RRB- denotes ]
T1042 3430-3431 . denotes .
T1043 3431-3610 sentence denotes Each of these QTL map to mouse distal chromosome 6 and are linked to the marker D6Mit13, which lies within a cluster of 24 intact Tas2rs in the C57BL/6 genome (e.g., [16,27,28]).
T1044 3432-3436 DT denotes Each
T1045 3450-3453 VBP denotes map
T1046 3437-3439 IN denotes of
T1047 3440-3445 DT denotes these
T1048 3446-3449 NN denotes QTL
T1049 3454-3456 IN denotes to
T1050 3457-3462 NN denotes mouse
T1051 3470-3480 NN denotes chromosome
T1052 3463-3469 JJ denotes distal
T1053 3481-3482 CD denotes 6
T1054 3483-3486 CC denotes and
T1055 3487-3490 VBP denotes are
T1056 3491-3497 VBN denotes linked
T1057 3498-3500 IN denotes to
T1058 3501-3504 DT denotes the
T1059 3512-3519 NN denotes D6Mit13
T1060 3505-3511 NN denotes marker
T1061 3519-3521 , denotes ,
T1062 3521-3526 WDT denotes which
T1063 3527-3531 VBZ denotes lies
T1064 3532-3538 IN denotes within
T1065 3539-3540 DT denotes a
T1066 3541-3548 NN denotes cluster
T1067 3549-3551 IN denotes of
T1068 3552-3554 CD denotes 24
T1069 3562-3568 NNS denotes Tas2rs
T1070 3555-3561 JJ denotes intact
T1071 3569-3571 IN denotes in
T1072 3572-3575 DT denotes the
T1073 3584-3590 NN denotes genome
T1074 3576-3581 NN denotes C57BL
T1075 3581-3582 HYPH denotes /
T1076 3582-3583 CD denotes 6
T1077 3591-3592 -LRB- denotes (
T1078 3605-3607 CD denotes 28
T1079 3592-3596 FW denotes e.g.
T1080 3596-3598 , denotes ,
T1081 3598-3599 -LRB- denotes [
T1082 3599-3601 CD denotes 16
T1083 3601-3602 , denotes ,
T1084 3602-3604 CD denotes 27
T1085 3604-3605 , denotes ,
T1086 3607-3608 -RRB- denotes ]
T1087 3608-3609 -RRB- denotes )
T1088 3609-3610 . denotes .
T1089 3610-3692 sentence denotes However, the interpretation of these studies remains problematic for two reasons.
T1090 3611-3618 RB denotes However
T1091 3656-3663 VBZ denotes remains
T1092 3618-3620 , denotes ,
T1093 3620-3623 DT denotes the
T1094 3624-3638 NN denotes interpretation
T1095 3639-3641 IN denotes of
T1096 3642-3647 DT denotes these
T1097 3648-3655 NNS denotes studies
T1098 3664-3675 JJ denotes problematic
T1099 3676-3679 IN denotes for
T1100 3680-3683 CD denotes two
T1101 3684-3691 NNS denotes reasons
T1102 3691-3692 . denotes .
T1103 3692-3887 sentence denotes First, the density of chromosomal markers and number of recombinant inbred (RI) strains used in these earlier studies did not permit the physical definition of the intervals containing each QTL.
T1104 3693-3698 RB denotes First
T1105 3819-3825 VB denotes permit
T1106 3698-3700 , denotes ,
T1107 3700-3703 DT denotes the
T1108 3704-3711 NN denotes density
T1109 3712-3714 IN denotes of
T1110 3715-3726 JJ denotes chromosomal
T1111 3727-3734 NNS denotes markers
T1112 3735-3738 CC denotes and
T1113 3739-3745 NN denotes number
T1114 3746-3748 IN denotes of
T1115 3749-3760 JJ denotes recombinant
T1116 3761-3767 JJ denotes inbred
T1117 3769-3771 JJ denotes RI
T1118 3768-3769 -LRB- denotes (
T1119 3773-3780 NNS denotes strains
T1120 3771-3772 -RRB- denotes )
T1121 3781-3785 VBN denotes used
T1122 3786-3788 IN denotes in
T1123 3789-3794 DT denotes these
T1124 3803-3810 NNS denotes studies
T1125 3795-3802 JJR denotes earlier
T1126 3811-3814 VBD denotes did
T1127 3815-3818 RB denotes not
T1128 3826-3829 DT denotes the
T1129 3839-3849 NN denotes definition
T1130 3830-3838 JJ denotes physical
T1131 3850-3852 IN denotes of
T1132 3853-3856 DT denotes the
T1133 3857-3866 NNS denotes intervals
T1134 3867-3877 VBG denotes containing
T1135 3878-3882 DT denotes each
T1136 3883-3886 NN denotes QTL
T1137 3886-3887 . denotes .
T1138 3887-4086 sentence denotes Second, these previous attempts to map bitter taste QTLs relied on behavioral assays that measured consumption, and were thus susceptible to contributions of post-ingestive effects such as toxicity.
T1139 3888-3894 RB denotes Second
T1140 3945-3951 VBD denotes relied
T1141 3894-3896 , denotes ,
T1142 3896-3901 DT denotes these
T1143 3911-3919 NNS denotes attempts
T1144 3902-3910 JJ denotes previous
T1145 3920-3922 TO denotes to
T1146 3923-3926 VB denotes map
T1147 3927-3933 JJ denotes bitter
T1148 3934-3939 NN denotes taste
T1149 3940-3944 NNS denotes QTLs
T1150 3952-3954 IN denotes on
T1151 3955-3965 JJ denotes behavioral
T1152 3966-3972 NNS denotes assays
T1153 3973-3977 WDT denotes that
T1154 3978-3986 VBN denotes measured
T1155 3987-3998 NN denotes consumption
T1156 3998-4000 , denotes ,
T1157 4000-4003 CC denotes and
T1158 4004-4008 VBD denotes were
T1159 4009-4013 RB denotes thus
T1160 4014-4025 JJ denotes susceptible
T1161 4026-4028 IN denotes to
T1162 4029-4042 NNS denotes contributions
T1163 4043-4045 IN denotes of
T1164 4046-4060 JJ denotes post-ingestive
T1165 4061-4068 NNS denotes effects
T1166 4069-4073 JJ denotes such
T1167 4074-4076 IN denotes as
T1168 4077-4085 NN denotes toxicity
T1169 4085-4086 . denotes .
T1170 4086-4192 sentence denotes As we have shown previously, such effects can confound the quantification of bitter taste behaviors [29].
T1171 4087-4089 IN denotes As
T1172 4098-4103 VBN denotes shown
T1173 4090-4092 PRP denotes we
T1174 4093-4097 VBP denotes have
T1175 4133-4141 VB denotes confound
T1176 4104-4114 RB denotes previously
T1177 4114-4116 , denotes ,
T1178 4116-4120 JJ denotes such
T1179 4121-4128 NNS denotes effects
T1180 4129-4132 MD denotes can
T1181 4142-4145 DT denotes the
T1182 4146-4160 NN denotes quantification
T1183 4161-4163 IN denotes of
T1184 4164-4170 JJ denotes bitter
T1185 4171-4176 NN denotes taste
T1186 4177-4186 NNS denotes behaviors
T1187 4187-4188 -LRB- denotes [
T1188 4188-4190 CD denotes 29
T1189 4190-4191 -RRB- denotes ]
T1190 4191-4192 . denotes .
T1191 4192-4296 sentence denotes Therefore, the relevance and/or contribution of the aforementioned QTLs to bitter taste remain unclear.
T1192 4193-4202 RB denotes Therefore
T1193 4281-4287 VBP denotes remain
T1194 4202-4204 , denotes ,
T1195 4204-4207 DT denotes the
T1196 4208-4217 NN denotes relevance
T1197 4218-4221 CC denotes and
T1198 4221-4222 HYPH denotes /
T1199 4222-4224 CC denotes or
T1200 4225-4237 NN denotes contribution
T1201 4238-4240 IN denotes of
T1202 4241-4244 DT denotes the
T1203 4260-4264 NNS denotes QTLs
T1204 4245-4259 JJ denotes aforementioned
T1205 4265-4267 IN denotes to
T1206 4268-4274 JJ denotes bitter
T1207 4275-4280 NN denotes taste
T1208 4288-4295 JJ denotes unclear
T1209 4295-4296 . denotes .
T1210 4296-4530 sentence denotes Furthermore, a number of physiological studies have suggested that the transduction of some amphiphilic bitter compounds, such as quinine and denatonium benzoate, may stimulate taste receptor cells independently of GPCRs (e.g. [30]).
T1211 4297-4308 RB denotes Furthermore
T1212 4349-4358 VBN denotes suggested
T1213 4308-4310 , denotes ,
T1214 4310-4311 DT denotes a
T1215 4312-4318 NN denotes number
T1216 4319-4321 IN denotes of
T1217 4322-4335 JJ denotes physiological
T1218 4336-4343 NNS denotes studies
T1219 4344-4348 VBP denotes have
T1220 4359-4363 IN denotes that
T1221 4464-4473 VB denotes stimulate
T1222 4364-4367 DT denotes the
T1223 4368-4380 NN denotes transduction
T1224 4381-4383 IN denotes of
T1225 4384-4388 DT denotes some
T1226 4408-4417 NNS denotes compounds
T1227 4389-4400 JJ denotes amphiphilic
T1228 4401-4407 JJ denotes bitter
T1229 4417-4419 , denotes ,
T1230 4419-4423 JJ denotes such
T1231 4424-4426 IN denotes as
T1232 4427-4434 NN denotes quinine
T1233 4435-4438 CC denotes and
T1234 4439-4449 NN denotes denatonium
T1235 4450-4458 NN denotes benzoate
T1236 4458-4460 , denotes ,
T1237 4460-4463 MD denotes may
T1238 4474-4479 NN denotes taste
T1239 4480-4488 NN denotes receptor
T1240 4489-4494 NNS denotes cells
T1241 4495-4508 RB denotes independently
T1242 4509-4511 IN denotes of
T1243 4512-4517 NNS denotes GPCRs
T1244 4518-4519 -LRB- denotes (
T1245 4525-4527 CD denotes 30
T1246 4519-4523 FW denotes e.g.
T1247 4524-4525 -LRB- denotes [
T1248 4527-4528 -RRB- denotes ]
T1249 4528-4529 -RRB- denotes )
T1250 4529-4530 . denotes .
T1251 4530-4736 sentence denotes Quinine may directly activate G proteins, and both quinine and denatonium can block K+ channels [31-36] ; caffeine, another bitter-tasting substance, directly inhibits intracellular phosphodiesterase [33].
T1252 4531-4538 NN denotes Quinine
T1253 4552-4560 VB denotes activate
T1254 4539-4542 MD denotes may
T1255 4543-4551 RB denotes directly
T1256 4690-4698 VBZ denotes inhibits
T1257 4561-4562 NN denotes G
T1258 4563-4571 NN denotes proteins
T1259 4571-4573 , denotes ,
T1260 4573-4576 CC denotes and
T1261 4577-4581 CC denotes both
T1262 4582-4589 NN denotes quinine
T1263 4609-4614 VB denotes block
T1264 4590-4593 CC denotes and
T1265 4594-4604 NN denotes denatonium
T1266 4605-4608 MD denotes can
T1267 4615-4616 NN denotes K
T1268 4618-4626 NNS denotes channels
T1269 4616-4617 SYM denotes +
T1270 4627-4628 -LRB- denotes [
T1271 4628-4630 CD denotes 31
T1272 4630-4631 SYM denotes -
T1273 4631-4633 CD denotes 36
T1274 4633-4634 -RRB- denotes ]
T1275 4635-4636 : denotes ;
T1276 4637-4645 NN denotes caffeine
T1277 4645-4647 , denotes ,
T1278 4647-4654 DT denotes another
T1279 4670-4679 NN denotes substance
T1280 4655-4661 JJ denotes bitter
T1281 4662-4669 VBG denotes tasting
T1282 4661-4662 HYPH denotes -
T1283 4679-4681 , denotes ,
T1284 4681-4689 RB denotes directly
T1285 4699-4712 JJ denotes intracellular
T1286 4713-4730 NN denotes phosphodiesterase
T1287 4731-4732 -LRB- denotes [
T1288 4732-4734 CD denotes 33
T1289 4734-4735 -RRB- denotes ]
T1290 4735-4736 . denotes .
T1291 4736-4874 sentence denotes However, the relative contributions of T2R-dependent and T2R-independent mechanisms to the detection of these bitter stimuli are unknown.
T1292 4737-4744 RB denotes However
T1293 4862-4865 VBP denotes are
T1294 4744-4746 , denotes ,
T1295 4746-4749 DT denotes the
T1296 4759-4772 NNS denotes contributions
T1297 4750-4758 JJ denotes relative
T1298 4773-4775 IN denotes of
T1299 4776-4779 NN denotes T2R
T1300 4780-4789 JJ denotes dependent
T1301 4779-4780 HYPH denotes -
T1302 4810-4820 NNS denotes mechanisms
T1303 4790-4793 CC denotes and
T1304 4794-4797 NN denotes T2R
T1305 4798-4809 JJ denotes independent
T1306 4797-4798 HYPH denotes -
T1307 4821-4823 IN denotes to
T1308 4824-4827 DT denotes the
T1309 4828-4837 NN denotes detection
T1310 4838-4840 IN denotes of
T1311 4841-4846 DT denotes these
T1312 4854-4861 NNS denotes stimuli
T1313 4847-4853 JJ denotes bitter
T1314 4866-4873 JJ denotes unknown
T1315 4873-4874 . denotes .
T1316 4874-5122 sentence denotes Here we use a taste-salient brief-access lick test [29,37] to measure taste sensitivities in C57BL/6J (B6), DBA/2J (D2) and BXD/Ty (BXD) recombinant inbred (RI) mice to two bitter stimuli, quinine hydrochloride (QHCl) and denatonium benzoate (DB).
T1317 4875-4879 RB denotes Here
T1318 4883-4886 VBP denotes use
T1319 4880-4882 PRP denotes we
T1320 4887-4888 DT denotes a
T1321 4921-4925 NN denotes test
T1322 4889-4894 NN denotes taste
T1323 4895-4902 JJ denotes salient
T1324 4894-4895 HYPH denotes -
T1325 4903-4908 JJ denotes brief
T1326 4909-4915 NN denotes access
T1327 4908-4909 HYPH denotes -
T1328 4916-4920 NN denotes lick
T1329 4926-4927 -LRB- denotes [
T1330 4930-4932 CD denotes 37
T1331 4927-4929 CD denotes 29
T1332 4929-4930 , denotes ,
T1333 4932-4933 -RRB- denotes ]
T1334 4934-4936 TO denotes to
T1335 4937-4944 VB denotes measure
T1336 4945-4950 NN denotes taste
T1337 4951-4964 NNS denotes sensitivities
T1338 4965-4967 IN denotes in
T1339 4968-4973 NN denotes C57BL
T1340 4974-4976 NN denotes 6J
T1341 4973-4974 HYPH denotes /
T1342 5036-5040 NNS denotes mice
T1343 4977-4978 -LRB- denotes (
T1344 4978-4980 NN denotes B6
T1345 4980-4981 -RRB- denotes )
T1346 4981-4983 , denotes ,
T1347 4983-4986 NN denotes DBA
T1348 4987-4989 NN denotes 2J
T1349 4986-4987 HYPH denotes /
T1350 4990-4991 -LRB- denotes (
T1351 4991-4993 NN denotes D2
T1352 4993-4994 -RRB- denotes )
T1353 4995-4998 CC denotes and
T1354 4999-5002 NN denotes BXD
T1355 5003-5005 NN denotes Ty
T1356 5002-5003 HYPH denotes /
T1357 5006-5007 -LRB- denotes (
T1358 5007-5010 NN denotes BXD
T1359 5010-5011 -RRB- denotes )
T1360 5012-5023 JJ denotes recombinant
T1361 5024-5030 JJ denotes inbred
T1362 5031-5032 -LRB- denotes (
T1363 5032-5034 JJ denotes RI
T1364 5034-5035 -RRB- denotes )
T1365 5041-5043 IN denotes to
T1366 5044-5047 CD denotes two
T1367 5055-5062 NNS denotes stimuli
T1368 5048-5054 JJ denotes bitter
T1369 5062-5064 , denotes ,
T1370 5064-5071 NN denotes quinine
T1371 5072-5085 NN denotes hydrochloride
T1372 5086-5087 -LRB- denotes (
T1373 5087-5091 NN denotes QHCl
T1374 5091-5092 -RRB- denotes )
T1375 5093-5096 CC denotes and
T1376 5097-5107 NN denotes denatonium
T1377 5108-5116 NN denotes benzoate
T1378 5117-5118 -LRB- denotes (
T1379 5118-5120 NN denotes DB
T1380 5120-5121 -RRB- denotes )
T1381 5121-5122 . denotes .
T1382 5122-5344 sentence denotes Using 17 BXD lines that were genotyped at 762 informative chromosomal markers, we mapped a major QTL for QHCl taste to a ~5 Mb interval on distal chromosome 6 that contains all 24 of the Tas2r genes in the distal cluster.
T1383 5123-5128 VBG denotes Using
T1384 5205-5211 VBD denotes mapped
T1385 5129-5131 CD denotes 17
T1386 5136-5141 NNS denotes lines
T1387 5132-5135 NN denotes BXD
T1388 5142-5146 WDT denotes that
T1389 5152-5161 VBN denotes genotyped
T1390 5147-5151 VBD denotes were
T1391 5162-5164 IN denotes at
T1392 5165-5168 CD denotes 762
T1393 5193-5200 NNS denotes markers
T1394 5169-5180 JJ denotes informative
T1395 5181-5192 JJ denotes chromosomal
T1396 5200-5202 , denotes ,
T1397 5202-5204 PRP denotes we
T1398 5212-5213 DT denotes a
T1399 5220-5223 NN denotes QTL
T1400 5214-5219 JJ denotes major
T1401 5224-5227 IN denotes for
T1402 5228-5232 NN denotes QHCl
T1403 5233-5238 NN denotes taste
T1404 5239-5241 IN denotes to
T1405 5242-5243 DT denotes a
T1406 5250-5258 NN denotes interval
T1407 5244-5245 SYM denotes ~
T1408 5245-5246 CD denotes 5
T1409 5247-5249 NN denotes Mb
T1410 5259-5261 IN denotes on
T1411 5262-5268 JJ denotes distal
T1412 5269-5279 NN denotes chromosome
T1413 5280-5281 CD denotes 6
T1414 5282-5286 WDT denotes that
T1415 5287-5295 VBZ denotes contains
T1416 5296-5299 DT denotes all
T1417 5300-5302 CD denotes 24
T1418 5303-5305 IN denotes of
T1419 5306-5309 DT denotes the
T1420 5316-5321 NNS denotes genes
T1421 5310-5315 NN denotes Tas2r
T1422 5322-5324 IN denotes in
T1423 5325-5328 DT denotes the
T1424 5336-5343 NN denotes cluster
T1425 5329-5335 JJ denotes distal
T1426 5343-5344 . denotes .
T1427 5344-5443 sentence denotes We analyzed the sequence of each Tas2r allele in the parental strains (B6 and D2) and 29 RI lines.
T1428 5345-5347 PRP denotes We
T1429 5348-5356 VBD denotes analyzed
T1430 5357-5360 DT denotes the
T1431 5361-5369 NN denotes sequence
T1432 5370-5372 IN denotes of
T1433 5373-5377 DT denotes each
T1434 5384-5390 NN denotes allele
T1435 5378-5383 NN denotes Tas2r
T1436 5391-5393 IN denotes in
T1437 5394-5397 DT denotes the
T1438 5407-5414 NNS denotes strains
T1439 5398-5406 JJ denotes parental
T1440 5415-5416 -LRB- denotes (
T1441 5416-5418 NN denotes B6
T1442 5419-5422 CC denotes and
T1443 5423-5425 NN denotes D2
T1444 5425-5426 -RRB- denotes )
T1445 5427-5430 CC denotes and
T1446 5431-5433 CD denotes 29
T1447 5437-5442 NNS denotes lines
T1448 5434-5436 JJ denotes RI
T1449 5442-5443 . denotes .
T1450 5443-5623 sentence denotes This analysis revealed that all 24 genes are polymorphic between the two strains, and that these 24 Tas2rs comprise a single haplotype that correlates with QHCl taste sensitivity.
T1451 5444-5448 DT denotes This
T1452 5449-5457 NN denotes analysis
T1453 5458-5466 VBD denotes revealed
T1454 5467-5471 IN denotes that
T1455 5485-5488 VBP denotes are
T1456 5472-5475 DT denotes all
T1457 5479-5484 NNS denotes genes
T1458 5476-5478 CD denotes 24
T1459 5489-5500 JJ denotes polymorphic
T1460 5501-5508 IN denotes between
T1461 5509-5512 DT denotes the
T1462 5517-5524 NNS denotes strains
T1463 5513-5516 CD denotes two
T1464 5524-5526 , denotes ,
T1465 5526-5529 CC denotes and
T1466 5530-5534 IN denotes that
T1467 5551-5559 VBP denotes comprise
T1468 5535-5540 DT denotes these
T1469 5544-5550 NNS denotes Tas2rs
T1470 5541-5543 CD denotes 24
T1471 5560-5561 DT denotes a
T1472 5569-5578 NN denotes haplotype
T1473 5562-5568 JJ denotes single
T1474 5579-5583 WDT denotes that
T1475 5584-5594 VBZ denotes correlates
T1476 5595-5599 IN denotes with
T1477 5600-5604 NN denotes QHCl
T1478 5605-5610 NN denotes taste
T1479 5611-5622 NN denotes sensitivity
T1480 5622-5623 . denotes .
T1522 5634-5639 NN denotes Taste
T1523 5640-5647 NN denotes testing
T1524 5647-5800 sentence denotes Previous efforts to map QTL for bitter taste have utilized consumption tests that may be confounded by the contributions of post-ingestive effects [29].
T1525 5648-5656 JJ denotes Previous
T1526 5657-5664 NNS denotes efforts
T1527 5698-5706 VBN denotes utilized
T1528 5665-5667 TO denotes to
T1529 5668-5671 VB denotes map
T1530 5672-5675 NN denotes QTL
T1531 5676-5679 IN denotes for
T1532 5680-5686 JJ denotes bitter
T1533 5687-5692 NN denotes taste
T1534 5693-5697 VBP denotes have
T1535 5707-5718 NN denotes consumption
T1536 5719-5724 NNS denotes tests
T1537 5725-5729 WDT denotes that
T1538 5737-5747 VBN denotes confounded
T1539 5730-5733 MD denotes may
T1540 5734-5736 VB denotes be
T1541 5748-5750 IN denotes by
T1542 5751-5754 DT denotes the
T1543 5755-5768 NNS denotes contributions
T1544 5769-5771 IN denotes of
T1545 5772-5786 JJ denotes post-ingestive
T1546 5787-5794 NNS denotes effects
T1547 5795-5796 -LRB- denotes [
T1548 5796-5798 CD denotes 29
T1549 5798-5799 -RRB- denotes ]
T1550 5799-5800 . denotes .
T1551 5800-6011 sentence denotes We used a modified brief-access lick test, which minimizes the contribution of such effects [29,37] to determine whether B6 and D2 mice display differences in taste sensitivity to the taste stimuli QHCl and DB.
T1552 5801-5803 PRP denotes We
T1553 5804-5808 VBD denotes used
T1554 5809-5810 DT denotes a
T1555 5838-5842 NN denotes test
T1556 5811-5819 VBN denotes modified
T1557 5820-5825 JJ denotes brief
T1558 5826-5832 NN denotes access
T1559 5825-5826 HYPH denotes -
T1560 5833-5837 NN denotes lick
T1561 5842-5844 , denotes ,
T1562 5844-5849 WDT denotes which
T1563 5850-5859 VBZ denotes minimizes
T1564 5860-5863 DT denotes the
T1565 5864-5876 NN denotes contribution
T1566 5877-5879 IN denotes of
T1567 5880-5884 JJ denotes such
T1568 5885-5892 NNS denotes effects
T1569 5893-5894 -LRB- denotes [
T1570 5897-5899 CD denotes 37
T1571 5894-5896 CD denotes 29
T1572 5896-5897 , denotes ,
T1573 5899-5900 -RRB- denotes ]
T1574 5901-5903 TO denotes to
T1575 5904-5913 VB denotes determine
T1576 5914-5921 IN denotes whether
T1577 5937-5944 VBP denotes display
T1578 5922-5924 NN denotes B6
T1579 5932-5936 NNS denotes mice
T1580 5925-5928 CC denotes and
T1581 5929-5931 NN denotes D2
T1582 5945-5956 NNS denotes differences
T1583 5957-5959 IN denotes in
T1584 5960-5965 NN denotes taste
T1585 5966-5977 NN denotes sensitivity
T1586 5978-5980 IN denotes to
T1587 5981-5984 DT denotes the
T1588 5991-5998 NNS denotes stimuli
T1589 5985-5990 NN denotes taste
T1590 5999-6003 NN denotes QHCl
T1591 6004-6007 CC denotes and
T1592 6008-6010 NN denotes DB
T1593 6010-6011 . denotes .
T1594 6011-6231 sentence denotes After initially screening B6 and D2 mice to determine stimulus concentrations that were aversive but not saturating [47], we selected two ligand concentrations for each compound that best differentiated the two strains.
T1595 6012-6017 IN denotes After
T1596 6137-6145 VBD denotes selected
T1597 6018-6027 RB denotes initially
T1598 6028-6037 VBG denotes screening
T1599 6038-6040 NN denotes B6
T1600 6048-6052 NNS denotes mice
T1601 6041-6044 CC denotes and
T1602 6045-6047 NN denotes D2
T1603 6053-6055 TO denotes to
T1604 6056-6065 VB denotes determine
T1605 6066-6074 NN denotes stimulus
T1606 6075-6089 NNS denotes concentrations
T1607 6090-6094 WDT denotes that
T1608 6095-6099 VBD denotes were
T1609 6100-6108 JJ denotes aversive
T1610 6109-6112 CC denotes but
T1611 6113-6116 RB denotes not
T1612 6117-6127 VBG denotes saturating
T1613 6128-6129 -LRB- denotes [
T1614 6129-6131 CD denotes 47
T1615 6131-6132 -RRB- denotes ]
T1616 6132-6134 , denotes ,
T1617 6134-6136 PRP denotes we
T1618 6146-6149 CD denotes two
T1619 6157-6171 NNS denotes concentrations
T1620 6150-6156 NN denotes ligand
T1621 6172-6175 IN denotes for
T1622 6176-6180 DT denotes each
T1623 6181-6189 NN denotes compound
T1624 6190-6194 WDT denotes that
T1625 6200-6214 VBD denotes differentiated
T1626 6195-6199 RBS denotes best
T1627 6215-6218 DT denotes the
T1628 6223-6230 NNS denotes strains
T1629 6219-6222 CD denotes two
T1630 6230-6231 . denotes .
T1631 6231-6350 sentence denotes Subsequent taste testing of BXD RI lines was restricted to these two concentrations (1 and 3 mM for both QHCl and DB).
T1632 6232-6242 JJ denotes Subsequent
T1633 6249-6256 NN denotes testing
T1634 6243-6248 NN denotes taste
T1635 6277-6287 VBN denotes restricted
T1636 6257-6259 IN denotes of
T1637 6260-6263 NN denotes BXD
T1638 6267-6272 NNS denotes lines
T1639 6264-6266 JJ denotes RI
T1640 6273-6276 VBD denotes was
T1641 6288-6290 IN denotes to
T1642 6291-6296 DT denotes these
T1643 6301-6315 NNS denotes concentrations
T1644 6297-6300 CD denotes two
T1645 6316-6317 -LRB- denotes (
T1646 6325-6327 NN denotes mM
T1647 6317-6318 CD denotes 1
T1648 6319-6322 CC denotes and
T1649 6323-6324 CD denotes 3
T1650 6328-6331 IN denotes for
T1651 6332-6336 CC denotes both
T1652 6337-6341 NN denotes QHCl
T1653 6342-6345 CC denotes and
T1654 6346-6348 NN denotes DB
T1655 6348-6349 -RRB- denotes )
T1656 6349-6350 . denotes .
T1657 6350-6524 sentence denotes Avoidance by male and female B6 and D2 mice increased (as indicated by the decreased lick ratio) in a concentration-dependent manner for both compounds (Figure 1A; Table 1).
T1658 6351-6360 NN denotes Avoidance
T1659 6395-6404 VBD denotes increased
T1660 6361-6363 IN denotes by
T1661 6364-6368 JJ denotes male
T1662 6390-6394 NNS denotes mice
T1663 6369-6372 CC denotes and
T1664 6373-6379 JJ denotes female
T1665 6380-6382 NN denotes B6
T1666 6383-6386 CC denotes and
T1667 6387-6389 NN denotes D2
T1668 6405-6406 -LRB- denotes (
T1669 6406-6408 IN denotes as
T1670 6409-6418 VBN denotes indicated
T1671 6419-6421 IN denotes by
T1672 6422-6425 DT denotes the
T1673 6441-6446 NN denotes ratio
T1674 6426-6435 VBN denotes decreased
T1675 6436-6440 NN denotes lick
T1676 6446-6447 -RRB- denotes )
T1677 6448-6450 IN denotes in
T1678 6451-6452 DT denotes a
T1679 6477-6483 NN denotes manner
T1680 6453-6466 NN denotes concentration
T1681 6467-6476 JJ denotes dependent
T1682 6466-6467 HYPH denotes -
T1683 6484-6487 IN denotes for
T1684 6488-6492 DT denotes both
T1685 6493-6502 NNS denotes compounds
T1686 6503-6504 -LRB- denotes (
T1687 6515-6520 NN denotes Table
T1688 6504-6510 NN denotes Figure
T1714 6596-6597 , denotes ,
T1715 6603-6607 CD denotes 24.6
T1716 6599-6600 -RRB- denotes ]
T1717 6601-6602 SYM denotes >
T1718 6607-6608 : denotes ;
T1719 6609-6610 NN denotes p
T1720 6611-6612 SYM denotes <
T1721 6619-6620 -RRB- denotes )
T1722 6620-6621 . denotes .
T1723 6621-6702 sentence denotes D2 mice displayed decreased aversion relative to B6 mice at both concentrations.
T1724 6622-6624 NN denotes D2
T1725 6625-6629 NNS denotes mice
T1726 6630-6639 VBD denotes displayed
T1727 6640-6649 VBN denotes decreased
T1728 6650-6658 NN denotes aversion
T1729 6659-6667 JJ denotes relative
T1730 6668-6670 IN denotes to
T1731 6671-6673 NN denotes B6
T1732 6674-6678 NNS denotes mice
T1733 6679-6681 IN denotes at
T1734 6682-6686 DT denotes both
T1735 6687-6701 NNS denotes concentrations
T1736 6701-6702 . denotes .
T1737 6702-6802 sentence denotes On the other hand, the strains did not significantly differ in taste sensitivity to DB (Figure 1A).
T1738 6703-6705 IN denotes On
T1739 6756-6762 VB denotes differ
T1740 6706-6709 DT denotes the
T1741 6716-6720 NN denotes hand
T1742 6710-6715 JJ denotes other
T1743 6720-6722 , denotes ,
T1744 6722-6725 DT denotes the
T1745 6726-6733 NNS denotes strains
T1746 6734-6737 VBD denotes did
T1747 6738-6741 RB denotes not
T1748 6742-6755 RB denotes significantly
T1749 6763-6765 IN denotes in
T1750 6766-6771 NN denotes taste
T1751 6772-6783 NN denotes sensitivity
T1752 6784-6786 IN denotes to
T1753 6787-6789 NN denotes DB
T1754 6790-6791 -LRB- denotes (
T1755 6791-6797 NN denotes Figure
T1756 6798-6800 CD denotes 1A
T1757 6800-6801 -RRB- denotes )
T1758 6801-6802 . denotes .
T1759 6802-6847 sentence denotes There were no significant effects of gender.
T1760 6803-6808 EX denotes There
T1761 6809-6813 VBD denotes were
T1762 6814-6816 DT denotes no
T1763 6829-6836 NNS denotes effects
T1764 6817-6828 JJ denotes significant
T1765 6837-6839 IN denotes of
T1766 6840-6846 NN denotes gender
T1767 6846-6847 . denotes .
T7344 6857-6861 NN denotes Mean
T7345 6867-6873 NNS denotes ratios
T7346 6862-6866 NN denotes lick
T7347 6874-6877 IN denotes for
T7348 6878-6880 NN denotes B6
T7349 6893-6897 NNS denotes mice
T7350 6880-6882 , denotes ,
T7351 6882-6884 NN denotes D2
T7352 6885-6888 CC denotes and
T7353 6889-6892 NN denotes BXD
T7354 6897-6898 . denotes .
T2067 10489-10491 NN denotes mM
T1689 6511-6513 CD denotes 1A
T1690 6513-6514 : denotes ;
T1691 6521-6522 CD denotes 1
T1692 6522-6523 -RRB- denotes )
T1693 6523-6524 . denotes .
T1694 6524-6621 sentence denotes There was a significant strain difference for both 1 and 3 mM QHCl (F[1,25] > 24.6; p < 0.0001).
T1695 6525-6530 EX denotes There
T1696 6531-6534 VBD denotes was
T1697 6535-6536 DT denotes a
T1698 6556-6566 NN denotes difference
T1699 6537-6548 JJ denotes significant
T1700 6549-6555 NN denotes strain
T1701 6567-6570 IN denotes for
T1702 6571-6575 DT denotes both
T1703 6587-6591 NN denotes QHCl
T1704 6576-6577 CD denotes 1
T1705 6584-6586 NN denotes mM
T1706 6578-6581 CC denotes and
T1707 6582-6583 CD denotes 3
T1708 6592-6593 -LRB- denotes (
T1709 6613-6619 CD denotes 0.0001
T1710 6593-6594 NN denotes F
T1711 6597-6599 CD denotes 25
T1712 6594-6595 -LRB- denotes [
T1713 6595-6596 CD denotes 1
T1770 9640-9646 VBD denotes tested
T1769 9632-9634 PRP denotes We
T1768 6847-9689 sentence denotes Table 1 Mean lick ratios for B6, D2 and BXD mice. Strain n Water licks/5s 1 mM DB 3 mM DB 3 mM PR 10 mM PR 1 mM QH 3 mM QH B6 16 29.02 ± 1.4 0.606 0.318 0.311 0.164 0.241 0.144 D2 12 33.91 ± 2.4 0.465 0.286 0.616 0.429 0.758 0.305 BXD1 5 32.48 ± 1.5 0.372 0.202 0.314 0.252 0.746 0.422 BXD2 4 36.50 ± 0.9 1.025 0.605 0.208 0.230 0.320 0.215 BXD5 5 37.23 ± 2.7 0.628 0.354 0.502 0.636 0.836 0.452 BXD6 5 22.43 ± 3.5 0.442 0.132 0.200 0.124 0.130 0.080 BXD11 7 34.48 ± 3.9 0.310 0.223 0.387 0.260 0.479 0.260 BXD13 5 27.74 ± 3.4 0.360 0.290 0.472 0.168 0.692 0.330 BXD14 7 31.09 ± 3.5 0.741 0.304 0.293 0.174 0.206 0.126 BXD15 5 37.36 ± 1.5 0.178 0.120 0.468 0.198 0.362 0.222 BXD20 5 31.26 ± 2.7 0.252 0.200 0.162 0.128 0.150 0.116 BXD21 6 19.77 ± 1.5 0.390 0.262 0.313 0.133 0.192 0.217 BXD24 5 33.03 ± 2.4 0.318 0.148 0.490 0.238 0.518 0.370 BXD27 5 33.46 ± 2.5 0.364 0.434 0.216 0.126 0.146 0.142 BXD29 3 40.19 ± 1.5 0.257 0.187 0.657 0.173 0.633 0.333 BXD31 5 19.45 ± 0.8 0.302 0.238 0.152 0.158 0.218 0.194 BXD32 6 27.22 ± 2.3 0.105 0.107 0.385 0.203 0.405 0.245 BXD33 6 29.03 ± 2.2 0.757 0.387 0.377 0.237 0.342 0.188 BXD34 6 23.01 ± 3.4 0.310 0.217 0.843 0.257 0.693 0.355 The number of individual mice tested for each strain (n) is listed in the second column. Subsequent columns show the mean lick rate to water during testing (± SEM), mean lick ratio for denatonium benzoate (DB), PROP (6-n-propylthiouracil; PR) and quinine hydrochloride (QH) at each of two concentrations (see Methods for details). Figure 1 Lick ratios (mean ± SE) for B6, D2 and BXD strains. (A) Mean lick ratios for B6 (filled circles) and D2 (open circles) mice at two concentrations of QHCl and DB. In all panels, a lower mean lick ratio indicates a greater aversion, and therefore greater taste sensitivity, to the stimulus. For panels B, C, and D, each BXD strain is represented by a different color, and listed in order from least sensitive to most sensitive to 1 mM QHCL. (B) Mean lick ratios for the six BXD strains that are most sensitive to QHCl in this assay. (C) Mean lick ratios for the five BXD strains that are least sensitive to QHCl in this assay. (D) Mean lick ratios for the six BXD strains intermediate in QHCl taste sensitivity to those in (B) and (C). Cutoffs for the three QHCl taster groups were arbitrarily set, as there was a continuity of the phenotype at 1 mM QHCl: sensitive strains exhibited a lick ratio for 1 mM QHCl of ≤ 0.3, intermediate strains from 0.31-0.6, and insensitive strains > 0.6. The absence of two distinct phenotypic classes suggests that sensitivity to QHCL is under polygenic control. We next tested mice from 17 BXD lines in the same manner.
T125 0-10 NNS denotes Haplotypes
T2109 10982-10983 NN denotes n
T2108 10982-10983 sentence denotes n
T2107 10981-10982 JJ denotes i
T2106 10981-10982 sentence denotes i
T2105 10980-10981 NN denotes l
T2104 10978-10979 NN denotes s
T2103 10977-10978 VBG denotes a
T2102 10976-10977 JJ denotes w
T2101 10972-10975 NN denotes QTL
T2100 10970-10971 CD denotes 6
T2099 10960-10969 NN denotes hromosome
T2098 10959-10960 JJ denotes c
T2097 10959-10981 sentence denotes chromosome 6 QTL was l
T2096 10956-10958 NN denotes he
T2095 10955-10956 NN denotes T
T2094 10955-10959 sentence denotes The
T2093 10600-10601 sentence denotes
T2092 10599-10600 . denotes .
T2091 10598-10599 -RRB- denotes )
T2090 10596-10598 CD denotes 2B
T2089 10589-10595 NN denotes Figure
T2088 10588-10589 -LRB- denotes (
T2087 10575-10587 NN denotes significance
T2086 10569-10570 HYPH denotes -
T2085 10570-10574 JJ denotes wide
T2084 10563-10569 NN denotes genome
T2083 10553-10556 RB denotes not
T2082 10557-10562 VB denotes reach
T2081 10549-10552 VBD denotes did
T2080 10545-10548 CC denotes but
T2079 10543-10544 -RRB- denotes )
T2078 10537-10538 SYM denotes >
T2077 10533-10536 NN denotes LRS
T2076 10539-10543 CD denotes 10.9
T2075 10532-10533 -LRB- denotes (
T2074 10521-10531 JJ denotes suggestive
T2073 10512-10515 NN denotes QTL
T2072 10506-10511 DT denotes these
T2071 10503-10505 IN denotes of
T2070 10498-10502 DT denotes both
T2069 10496-10498 , denotes ,
T2068 10492-10496 NN denotes QHCl
T2119 11025-11031 NN denotes Figure
T2117 11007-11014 NN denotes D6Mit13
T2116 11005-11007 , denotes ,
T2115 10992-10998 JJ denotes single
T2114 10999-11005 NN denotes marker
T2113 10990-10991 DT denotes a
T2112 10987-10989 IN denotes to
T2111 10983-10986 VBN denotes ked
T2110 10983-11035 sentence denotes ked to a single marker, D6Mit13 (Table 2, Figure 3).
T3154 16673-16684 NN denotes variability
T3153 16673-16913 sentence denotes variability between orthologous receptors in these two inbred strains suggested that it might be possible to narrow the physical boundaries of the QHCl taste QTL by determining which Tas2r alleles are correlated with QHCl taste sensitivity.
T3152 16670-16672 DT denotes he
T3151 16670-16673 sentence denotes he
T3150 16669-16670 NNS denotes T
T3149 16669-16670 sentence denotes T
T3148 16158-16159 sentence denotes
T3147 16157-16158 . denotes .
T3146 16156-16157 -RRB- denotes )
T3145 16147-16150 RB denotes not
T4786 24590-24594 IN denotes that
T4785 24581-24589 JJ denotes possible
T4784 24578-24580 VBZ denotes is
T4783 24575-24577 PRP denotes It
T4782 24574-24757 sentence denotes It is possible that B6 and D2 mice, which have a similar origin in the early 20th century, inherited different Tas2r haplotypes present in wild mouse populations prior to inbreeding.
T4781 24573-24574 . denotes .
T4780 24562-24573 JJ denotes problematic
T4779 24550-24561 NN denotes explanation
T4778 24545-24549 DT denotes this
T4777 24531-24538 JJ denotes related
T4776 24523-24530 RB denotes closely
T4775 24520-24522 RB denotes so
T4774 24514-24516 , denotes ,
T4773 24502-24506 JJ denotes same
T4772 24507-24514 NNS denotes species
T4771 24498-24501 DT denotes the
T4770 24495-24497 IN denotes of
T4769 24487-24494 NNS denotes members
T4768 24485-24487 , denotes ,
T4767 24472-24477 NN denotes mouse
T4766 24468-24471 CD denotes two
T4765 24478-24485 NNS denotes strains
T4764 24462-24467 DT denotes these
T4763 24516-24519 VBP denotes are
T4762 24457-24461 IN denotes that
R4955 T6597 T6598 det A,QTL
R4956 T6599 T6598 amod major,QTL
R4957 T6600 T6598 prep for,QTL
R4958 T6601 T6602 compound QHCl,taste
R4959 T6602 T6600 pobj taste,for
R4960 T6603 T6598 prep on,QTL
R4961 T6604 T6605 compound mouse,chromosome
R4962 T6605 T6603 pobj chromosome,on
R4963 T6606 T6605 nummod 6,chromosome
R4964 T6607 T6598 punct .,QTL
R4965 T6609 T6610 punct (,panel
R4966 T6610 T6612 parataxis panel,shows
R4967 T6611 T6610 amod Top,panel
R4968 T6613 T6610 punct ),panel
R4969 T6614 T6615 det The,map
R4970 T6615 T6612 nsubj map,shows
R4971 T6616 T6615 compound interval,map
R4972 T6617 T6618 punct (,see
R4973 T6618 T6615 parataxis see,map
R4974 T6619 T6618 dobj Methods,see
R4975 T6620 T6618 punct ),see
R4976 T6621 T6622 det a,QTL
R4977 T6622 T6612 dobj QTL,shows
R4978 T6623 T6622 amod significant,QTL
R4979 T6624 T6622 prep on,QTL
R4980 T6625 T6624 pobj chromosome,on
R4981 T6626 T6625 nummod 6,chromosome
R4982 T6627 T6628 punct (,green
R4983 T6628 T6625 parataxis green,chromosome
R4984 T6629 T6628 punct ),green
R4985 T6630 T6622 cc and,QTL
R4986 T6631 T6632 det a,QTL
R4987 T6632 T6622 conj QTL,QTL
R4988 T6633 T6632 amod suggestive,QTL
R4989 T6634 T6632 prep on,QTL
R4990 T6635 T6634 pobj chromosome,on
R4991 T6636 T6635 nummod 8,chromosome
R4992 T6637 T6638 punct (,yellow
R4993 T6638 T6635 parataxis yellow,chromosome
R4994 T6639 T6638 punct ),yellow
R4995 T6640 T6622 acl affecting,QTL
R4996 T6641 T6642 compound taste,responses
R4997 T6642 T6640 dobj responses,affecting
R4998 T6643 T6642 prep to,responses
R4999 T6644 T6645 nummod 1,mM
R5000 T6645 T6646 compound mM,QHCl
R5001 T6646 T6643 pobj QHCl,to
R5002 T6647 T6612 punct .,shows
R5003 T6649 T6650 punct (,panel
R5004 T6650 T6652 parataxis panel,were
R5005 T6651 T6650 amod Bottom,panel
R5006 T6653 T6650 punct ),panel
R5007 T6654 T6652 prep For,were
R5008 T6655 T6656 nummod 3,mM
R5009 T6656 T6657 compound mM,QHCl
R5010 T6657 T6654 pobj QHCl,For
R5011 T6658 T6652 punct ", ",were
R5012 T6659 T6660 det both,QTL
R5013 T6660 T6652 nsubj QTL,were
R5014 T6661 T6652 acomp suggestive,were
R5015 T6662 T6663 punct (,yellow
R5016 T6663 T6661 parataxis yellow,suggestive
R5017 T6664 T6663 punct ),yellow
R5018 T6665 T6652 punct .,were
R5019 T6667 T6668 det The,line
R5020 T6668 T6670 nsubj line,indicates
R5021 T6669 T6668 amod dashed,line
R5022 T6671 T6672 npadvmod genome,wide
R5023 T6672 T6674 amod wide,significance
R5024 T6673 T6672 punct -,wide
R5025 T6674 T6670 dobj significance,indicates
R5026 T6675 T6670 punct .,indicates
R5027 T6700 T6701 det The,QTL
R5028 T6701 T6703 nsubjpass QTL,linked
R5029 T6702 T6701 compound QHCl,QTL
R5030 T6704 T6703 auxpass is,linked
R5031 T6705 T6703 prep to,linked
R5032 T6706 T6707 det a,marker
R5033 T6707 T6705 pobj marker,to
R5034 T6708 T6707 amod single,marker
R5035 T6709 T6707 prep on,marker
R5036 T6710 T6709 pobj chromosome,on
R5037 T6711 T6710 nummod 6,chromosome
R5038 T6712 T6703 punct .,linked
R5039 T6714 T6715 punct (,A
R5040 T6715 T6716 meta A,correlates
R5041 T6717 T6715 punct ),A
R5042 T6718 T6719 mark As,shown
R5043 T6719 T6716 advcl shown,correlates
R5044 T6720 T6719 prep in,shown
R5045 T6721 T6722 det the,map
R5046 T6722 T6720 pobj map,in
R5047 T6723 T6722 amod interval,map
R5048 T6724 T6722 prep for,map
R5049 T6725 T6724 pobj chromosome,for
R5050 T6726 T6725 nummod 6,chromosome
R5051 T6727 T6716 punct ", ",correlates
R5052 T6728 T6729 det the,value
R5053 T6729 T6716 nsubj value,correlates
R5054 T6730 T6729 compound trait,value
R5055 T6731 T6729 punct (,value
R5056 T6732 T6733 compound lick,ratio
R5057 T6733 T6729 appos ratio,value
R5058 T6734 T6733 prep for,ratio
R5059 T6735 T6736 nummod 1,mM
R5060 T6736 T6737 compound mM,QHCl
R5061 T6737 T6734 pobj QHCl,for
R5062 T6738 T6716 punct ),correlates
R5063 T6739 T6716 advmod strongly,correlates
R5064 T6740 T6716 prep across,correlates
R5065 T6741 T6742 nmod BXD,strains
R5066 T6742 T6740 pobj strains,across
R5067 T6743 T6742 amod RI,strains
R5068 T6744 T6716 prep with,correlates
R5069 T6745 T6746 det the,marker
R5070 T6746 T6744 pobj marker,with
R5071 T6747 T6746 amod polymorphic,marker
R5072 T6748 T6746 appos D6Mit13,marker
R5073 T6749 T6750 punct (,bold
R5074 T6750 T6746 parataxis bold,marker
R5075 T6751 T6750 punct ),bold
R5076 T6752 T6716 punct .,correlates
R5077 T6754 T6755 det The,line
R5078 T6755 T6757 nsubj line,indicates
R5079 T6756 T6755 amod dashed,line
R5080 T6758 T6759 npadvmod genome,wide
R5081 T6759 T6761 amod wide,significance
R5082 T6760 T6759 punct -,wide
R5083 T6761 T6757 dobj significance,indicates
R5084 T6762 T6757 punct .,indicates
R5085 T6764 T6765 punct (,B
R5086 T6765 T6766 meta B,contains
R5087 T6767 T6765 punct ),B
R5088 T6768 T6769 det The,QTL
R5089 T6769 T6766 nsubj QTL,contains
R5090 T6770 T6769 compound QHCl,QTL
R5091 T6771 T6769 punct (,QTL
R5092 T6772 T6773 dep which,lies
R5093 T6773 T6769 relcl lies,QTL
R5094 T6774 T6773 prep between,lies
R5095 T6775 T6776 amod unlinked,markers
R5096 T6776 T6774 pobj markers,between
R5097 T6777 T6776 appos D6Mit61,markers
R5098 T6778 T6777 cc and,D6Mit61
R5099 T6779 T6777 conj D6Mit,D6Mit61
R5100 T6780 T6779 nummod 374,D6Mit
R5101 T6781 T6769 punct ),QTL
R5102 T6782 T6783 det a,cluster
R5103 T6783 T6766 dobj cluster,contains
R5104 T6784 T6783 prep of,cluster
R5105 T6785 T6786 amod putative,genes
R5106 T6786 T6784 pobj genes,of
R5107 T6787 T6788 amod bitter,taste
R5108 T6788 T6786 compound taste,genes
R5109 T6789 T6786 compound receptor,genes
R5110 T6790 T6783 punct ", ",cluster
R5111 T6791 T6792 det the,Tas2rs
R5112 T6792 T6783 appos Tas2rs,cluster
R5113 T6793 T6794 punct (,box
R5114 T6794 T6783 parataxis box,cluster
R5115 T6795 T6794 amod gray,box
R5116 T6796 T6794 punct ),box
R5117 T6797 T6766 punct .,contains
R5118 T6799 T6800 amod Physical,positions
R5119 T6800 T6801 nsubjpass positions,given
R5120 T6802 T6800 prep of,positions
R5121 T6803 T6804 det the,markers
R5122 T6804 T6802 pobj markers,of
R5123 T6805 T6804 amod polymorphic,markers
R5124 T6806 T6801 auxpass are,given
R5125 T6807 T6801 prep in,given
R5126 T6808 T6807 pobj Mb,in
R5127 T6809 T6801 punct ", ",given
R5128 T6810 T6801 cc and,given
R5129 T6811 T6812 auxpass are,based
R5130 T6812 T6801 conj based,given
R5131 T6813 T6812 prep on,based
R5132 T6814 T6815 det the,build
R5133 T6815 T6813 pobj build,on
R5134 T6816 T6815 nmod May,build
R5135 T6817 T6816 punct ", ",May
R5136 T6818 T6816 npadvmod 2004,May
R5137 T6819 T6815 prep of,build
R5138 T6820 T6821 det the,genome
R5139 T6821 T6819 pobj genome,of
R5140 T6822 T6821 compound B6,genome
R5141 T6823 T6821 compound mouse,genome
R5142 T6824 T6801 punct .,given
R5143 T6826 T6827 det The,position
R5144 T6827 T6829 nsubj position,is
R5145 T6828 T6827 amod physical,position
R5146 T6830 T6827 prep of,position
R5147 T6831 T6830 pobj D6Mit194,of
R5148 T6832 T6833 punct (,*
R5149 T6833 T6827 punct *,position
R5150 T6834 T6833 punct ),*
R5151 T6835 T6829 acomp tentative,is
R5152 T6836 T6829 punct .,is
R5154 T6866 T6867 det A,map
R5155 T6868 T6867 prep of,map
R5156 T6869 T6870 det the,cluster
R5157 T6870 T6868 pobj cluster,of
R5158 T6871 T6870 amod distal,cluster
R5159 T6872 T6870 nmod chromosome,cluster
R5160 T6873 T6872 nummod 6,chromosome
R5161 T6874 T6870 compound Tas2r,cluster
R5162 T6875 T6867 punct .,map
R5163 T6877 T6878 compound Twenty,four
R5164 T6878 T6880 nummod four,genes
R5165 T6879 T6878 punct -,four
R5166 T6880 T6883 nsubj genes,map
R5167 T6881 T6880 amod intact,genes
R5168 T6882 T6880 compound Tas2r,genes
R5169 T6884 T6883 prep to,map
R5170 T6885 T6886 amod distal,chromosome
R5171 T6886 T6884 pobj chromosome,to
R5172 T6887 T6886 nummod 6,chromosome
R5173 T6888 T6889 punct (,black
R5174 T6889 T6886 parataxis black,chromosome
R5175 T6890 T6889 punct ),black
R5176 T6891 T6883 punct .,map
R5177 T6893 T6894 det The,Tas2rs
R5178 T6894 T6895 nsubjpass Tas2rs,found
R5179 T6896 T6895 auxpass are,found
R5180 T6897 T6895 prep in,found
R5181 T6898 T6899 nummod two,subclusters
R5182 T6899 T6897 pobj subclusters,in
R5183 T6900 T6899 prep on,subclusters
R5184 T6901 T6902 det either,side
R5185 T6902 T6900 pobj side,on
R5186 T6903 T6902 prep of,side
R5187 T6904 T6905 det the,D6Mit13
R5188 T6905 T6903 pobj D6Mit13,of
R5189 T6906 T6905 amod polymorphic,D6Mit13
R5190 T6907 T6905 compound marker,D6Mit13
R5191 T6908 T6909 punct (,red
R5192 T6909 T6905 parataxis red,D6Mit13
R5193 T6910 T6909 punct ),red
R5194 T6911 T6899 cc and,subclusters
R5195 T6912 T6913 nummod two,genes
R5196 T6913 T6899 conj genes,subclusters
R5197 T6914 T6913 acl encoding,genes
R5198 T6915 T6916 npadvmod proline,rich
R5199 T6916 T6918 amod rich,proteins
R5200 T6917 T6916 punct -,rich
R5201 T6918 T6914 dobj proteins,encoding
R5202 T6919 T6918 amod salivary,proteins
R5203 T6920 T6918 punct (,proteins
R5204 T6921 T6918 appos Prp2,proteins
R5205 T6922 T6921 cc and,Prp2
R5206 T6923 T6921 conj Prh1,Prp2
R5207 T6924 T6925 punct ;,red
R5208 T6925 T6918 parataxis red,proteins
R5209 T6926 T6925 punct ),red
R5210 T6927 T6895 punct .,found
R5211 T6929 T6930 compound Map,positions
R5212 T6930 T6931 nsubj positions,represent
R5213 T6932 T6930 punct ", ",positions
R5214 T6933 T6930 prep in,positions
R5215 T6934 T6933 pobj Mb,in
R5216 T6935 T6931 punct ", ",represent
R5217 T6936 T6937 nmod chromosome,positions
R5218 T6937 T6931 dobj positions,represent
R5219 T6938 T6936 nummod 6,chromosome
R5220 T6939 T6937 prep in,positions
R5221 T6940 T6941 det the,assembly
R5222 T6941 T6939 pobj assembly,in
R5223 T6942 T6941 nmod May,assembly
R5224 T6943 T6942 punct ", ",May
R5225 T6944 T6942 npadvmod 2004,May
R5226 T6945 T6941 prep of,assembly
R5227 T6946 T6947 det the,genome
R5228 T6947 T6945 pobj genome,of
R5229 T6948 T6947 compound B6,genome
R5230 T6949 T6931 punct .,represent
R5231 T6978 T6979 amod Allelic,variation
R5232 T6980 T6979 prep across,variation
R5233 T6981 T6980 pobj strains,across
R5234 T6982 T6979 prep for,variation
R5235 T6983 T6984 nummod four,Tas2rs
R5236 T6984 T6982 pobj Tas2rs,for
R5237 T6985 T6979 punct .,variation
R5238 T6987 T6988 nmod B6,alleles
R5239 T6988 T6991 nsubjpass alleles,differentiated
R5240 T6989 T6987 cc and,B6
R5241 T6990 T6987 conj D2,B6
R5242 T6992 T6988 prep of,alleles
R5243 T6993 T6994 nummod four,Tas2rs
R5244 T6994 T6992 pobj Tas2rs,of
R5245 T6995 T6991 aux can,differentiated
R5246 T6996 T6991 auxpass be,differentiated
R5247 T6997 T6991 prep based,differentiated
R5248 T6998 T6997 prep on,based
R5249 T6999 T7000 amod diagnostic,digests
R5250 T7000 T6998 pobj digests,on
R5251 T7001 T7000 compound restriction,digests
R5252 T7002 T7000 prep of,digests
R5253 T7003 T7004 amod amplified,products
R5254 T7004 T7002 pobj products,of
R5255 T7005 T7004 compound PCR,products
R5256 T7006 T7004 punct (,products
R5257 T7007 T7004 appos Tas2r105,products
R5258 T7008 T7007 punct ", ",Tas2r105
R5259 T7009 T7007 conj Tas2r116,Tas2r105
R5260 T7010 T7009 cc and,Tas2r116
R5261 T7011 T7009 conj Tas2r131,Tas2r116
R5262 T7012 T6998 punct ),on
R5263 T7013 T6998 cc or,on
R5264 T7014 T6998 conj on,on
R5265 T7015 T7016 det the,presence
R5266 T7016 T7014 pobj presence,on
R5267 T7017 T7016 cc or,presence
R5268 T7018 T7016 conj absence,presence
R5269 T7019 T7016 prep of,presence
R5270 T7020 T7021 det a,product
R5271 T7021 T7019 pobj product,of
R5272 T7022 T7021 compound PCR,product
R5273 T7023 T7021 punct (,product
R5274 T7024 T7021 appos Tas2r120,product
R5275 T7025 T6991 punct ),differentiated
R5276 T7026 T6991 punct .,differentiated
R5277 T7028 T7029 prep In,correlated
R5278 T7030 T7028 pobj each,In
R5279 T7031 T7030 prep of,each
R5280 T7032 T7033 det the,strains
R5281 T7033 T7031 pobj strains,of
R5282 T7034 T7033 nummod 17,strains
R5283 T7035 T7033 compound BXD,strains
R5284 T7036 T7033 acl tested,strains
R5285 T7037 T7029 punct ", ",correlated
R5286 T7038 T7039 compound Tas2r,genotype
R5287 T7039 T7029 nsubjpass genotype,correlated
R5288 T7040 T7029 auxpass was,correlated
R5289 T7041 T7029 advmod always,correlated
R5290 T7042 T7029 prep with,correlated
R5291 T7043 T7044 compound QHCl,taster
R5292 T7044 T7045 compound taster,phenotype
R5293 T7045 T7042 pobj phenotype,with
R5294 T7046 T7047 punct (,phenotype
R5295 T7047 T7045 parataxis phenotype,phenotype
R5296 T7048 T7049 nsubj blue,phenotype
R5297 T7049 T7047 ccomp phenotype,phenotype
R5298 T7050 T7049 punct =,phenotype
R5299 T7051 T7052 compound B6,taster
R5300 T7052 T7049 compound taster,phenotype
R5301 T7053 T7047 punct ", ",phenotype
R5302 T7054 T7047 nsubj red,phenotype
R5303 T7055 T7047 punct =,phenotype
R5304 T7056 T7057 compound D2,taster
R5305 T7057 T7047 compound taster,phenotype
R5306 T7058 T7047 punct ),phenotype
R5307 T7059 T7029 punct .,correlated
R5308 T7062 T7063 amod additional,file
R5309 T7063 T7061 dobj file,See
R5310 T7064 T7063 nummod 1,file
R5311 T7065 T7063 punct : ,file
R5312 T7066 T7063 npadvmod Table,file
R5313 T7067 T7066 nummod 3,Table
R5314 T7068 T7061 prep for,See
R5315 T7069 T7070 compound restriction,enzymes
R5316 T7070 T7068 pobj enzymes,for
R5317 T7071 T7070 cc and,enzymes
R5318 T7072 T7070 conj oligonucleotides,enzymes
R5319 T7073 T7061 punct .,See
R5320 T7095 T7096 det The,cluster
R5321 T7096 T7098 nsubj cluster,is
R5322 T7097 T7096 compound Tas2r,cluster
R5323 T7099 T7100 det a,haplotype
R5324 T7100 T7098 attr haplotype,is
R5325 T7101 T7100 amod single,haplotype
R5326 T7102 T7098 prep in,is
R5327 T7103 T7104 nmod BXD,Ty
R5328 T7104 T7106 nmod Ty,mice
R5329 T7105 T7104 punct /,Ty
R5330 T7106 T7102 pobj mice,in
R5331 T7107 T7106 amod RI,mice
R5332 T7108 T7098 punct .,is
R5333 T7110 T7111 det The,exon
R5334 T7111 T7113 nsubj exon,was
R5335 T7112 T7111 amod coding,exon
R5336 T7114 T7111 prep of,exon
R5337 T7115 T7114 pobj each,of
R5338 T7116 T7115 prep of,each
R5339 T7117 T7118 nummod 21,Tas2rs
R5340 T7118 T7116 pobj Tas2rs,of
R5341 T7119 T7118 prep in,Tas2rs
R5342 T7120 T7121 det the,cluster
R5343 T7121 T7119 pobj cluster,in
R5344 T7122 T7121 amod distal,cluster
R5345 T7123 T7121 nmod chromosome,cluster
R5346 T7124 T7123 nummod 6,chromosome
R5347 T7125 T7126 amod amplified,DNA
R5348 T7126 T7113 attr DNA,was
R5349 T7127 T7126 amod genomic,DNA
R5350 T7128 T7126 prep from,DNA
R5351 T7129 T7130 nummod 29,strains
R5352 T7130 T7128 pobj strains,from
R5353 T7131 T7132 nmod BXD,Ty
R5354 T7132 T7130 nmod Ty,strains
R5355 T7133 T7132 punct /,Ty
R5356 T7134 T7130 amod RI,strains
R5357 T7135 T7113 punct .,was
R5358 T7137 T7138 det Each,Tas2r
R5359 T7138 T7139 nsubj Tas2r,originated
R5360 T7140 T7138 prep within,Tas2r
R5361 T7141 T7142 det an,strain
R5362 T7142 T7140 pobj strain,within
R5363 T7143 T7142 amod individual,strain
R5364 T7144 T7142 compound BXD,strain
R5365 T7145 T7139 prep from,originated
R5366 T7146 T7147 det the,strain
R5367 T7147 T7145 pobj strain,from
R5368 T7148 T7147 amod same,strain
R5369 T7149 T7147 amod parental,strain
R5370 T7150 T7151 punct (,white
R5371 T7151 T7139 parataxis white,originated
R5372 T7152 T7153 compound B6,allele
R5373 T7153 T7154 nsubj allele,gray
R5374 T7154 T7151 ccomp gray,white
R5375 T7155 T7154 punct =,gray
R5376 T7156 T7151 punct ", ",white
R5377 T7157 T7158 compound D2,allele
R5378 T7158 T7151 nsubj allele,white
R5379 T7159 T7151 punct =,white
R5380 T7160 T7151 punct ),white
R5381 T7161 T7139 punct .,originated
R5382 T7163 T7164 det The,strains
R5383 T7164 T7167 nsubjpass strains,indicated
R5384 T7165 T7164 nummod 17,strains
R5385 T7166 T7164 compound BXD,strains
R5386 T7168 T7169 dep that,tested
R5387 T7169 T7164 relcl tested,strains
R5388 T7170 T7169 auxpass were,tested
R5389 T7171 T7169 advmod behaviorally,tested
R5390 T7172 T7169 prep in,tested
R5391 T7173 T7174 det this,study
R5392 T7174 T7172 pobj study,in
R5393 T7175 T7167 auxpass are,indicated
R5394 T7176 T7177 punct (,*
R5395 T7177 T7167 punct *,indicated
R5396 T7178 T7177 punct ),*
R5397 T7179 T7167 punct .,indicated
R5398 T7207 T7208 compound Tas2r,genotype
R5399 T7208 T7209 nsubj genotype,correlates
R5400 T7210 T7209 prep with,correlates
R5401 T7211 T7212 compound QHCl,taste
R5402 T7212 T7213 compound taste,phenotype
R5403 T7213 T7210 pobj phenotype,with
R5404 T7214 T7209 punct .,correlates
R5405 T7216 T7217 compound Mean,ratios
R5406 T7217 T7219 nsubjpass ratios,grouped
R5407 T7218 T7217 compound lick,ratios
R5408 T7220 T7217 prep of,ratios
R5409 T7221 T7222 nmod B6,strains
R5410 T7222 T7220 pobj strains,of
R5411 T7223 T7221 punct ", ",B6
R5412 T7224 T7221 conj D2,B6
R5413 T7225 T7224 cc and,D2
R5414 T7226 T7224 conj BXD,D2
R5415 T7227 T7222 acl reported,strains
R5416 T7228 T7227 prep in,reported
R5417 T7229 T7228 pobj Figure,in
R5418 T7230 T7229 nummod 1,Figure
R5419 T7231 T7219 auxpass are,grouped
R5420 T7232 T7219 prep based,grouped
R5421 T7233 T7232 prep on,based
R5422 T7234 T7235 compound Tas2r,haplotype
R5423 T7235 T7233 pobj haplotype,on
R5424 T7236 T7237 punct (,red
R5425 T7237 T7219 parataxis red,grouped
R5426 T7238 T7239 compound B6,haplotype
R5427 T7239 T7240 nsubj haplotype,blue
R5428 T7240 T7237 ccomp blue,red
R5429 T7241 T7240 punct =,blue
R5430 T7242 T7237 punct ", ",red
R5431 T7243 T7244 compound D2,haplotype
R5432 T7244 T7237 nsubj haplotype,red
R5433 T7245 T7237 punct =,red
R5434 T7246 T7237 punct ),red
R5435 T7247 T7219 punct .,grouped
R5436 T7249 T7250 compound B6,mice
R5437 T7250 T7251 nsubj mice,are
R5438 T7252 T7253 punct (,line
R5439 T7253 T7250 parataxis line,mice
R5440 T7254 T7253 amod blue,line
R5441 T7255 T7253 prep on,line
R5442 T7256 T7257 amod left,panel
R5443 T7257 T7255 pobj panel,on
R5444 T7258 T7253 punct ),line
R5445 T7259 T7260 advmod more,sensitive
R5446 T7260 T7251 acomp sensitive,are
R5447 T7261 T7260 prep to,sensitive
R5448 T7262 T7263 nummod 1,mM
R5449 T7263 T7264 nmod mM,QHCl
R5450 T7264 T7261 pobj QHCl,to
R5451 T7265 T7263 cc and,mM
R5452 T7266 T7267 nummod 3,mM
R5453 T7267 T7263 conj mM,mM
R5454 T7268 T7269 mark than,are
R5455 T7269 T7260 advcl are,sensitive
R5456 T7270 T7271 compound D2,mice
R5457 T7271 T7269 nsubj mice,are
R5458 T7272 T7273 punct (,line
R5459 T7273 T7271 parataxis line,mice
R5460 T7274 T7273 amod red,line
R5461 T7275 T7273 prep on,line
R5462 T7276 T7277 amod left,panel
R5463 T7277 T7275 pobj panel,on
R5464 T7278 T7273 punct ),line
R5465 T7279 T7269 prep in,are
R5466 T7280 T7281 amod brief,access
R5467 T7281 T7282 compound access,tests
R5468 T7282 T7279 pobj tests,in
R5469 T7283 T7282 compound taste,tests
R5470 T7284 T7251 punct .,are
R5471 T7286 T7287 advmod Similarly,are
R5472 T7288 T7287 punct ", ",are
R5473 T7289 T7290 compound BXD,strains
R5474 T7290 T7287 nsubj strains,are
R5475 T7291 T7290 prep with,strains
R5476 T7292 T7293 det the,haplotype
R5477 T7293 T7291 pobj haplotype,with
R5478 T7294 T7295 compound B6,Tas2r
R5479 T7295 T7293 compound Tas2r,haplotype
R5480 T7296 T7297 punct (,panel
R5481 T7297 T7293 parataxis panel,haplotype
R5482 T7298 T7299 amod blue,lines
R5483 T7299 T7297 dep lines,panel
R5484 T7300 T7297 punct ", ",panel
R5485 T7301 T7297 amod right,panel
R5486 T7302 T7297 punct ),panel
R5487 T7303 T7304 advmod more,sensitive
R5488 T7304 T7287 acomp sensitive,are
R5489 T7305 T7304 prep to,sensitive
R5490 T7306 T7305 pobj QHCl,to
R5491 T7307 T7308 mark than,are
R5492 T7308 T7304 advcl are,sensitive
R5493 T7309 T7310 compound BXD,strains
R5494 T7310 T7308 nsubj strains,are
R5495 T7311 T7310 prep with,strains
R5496 T7312 T7313 det the,haplotype
R5497 T7313 T7311 pobj haplotype,with
R5498 T7314 T7315 compound D2,Tas2r
R5499 T7315 T7313 compound Tas2r,haplotype
R5500 T7316 T7317 punct (,panel
R5501 T7317 T7308 parataxis panel,are
R5502 T7318 T7319 amod red,lines
R5503 T7319 T7317 dep lines,panel
R5504 T7320 T7317 punct ", ",panel
R5505 T7321 T7317 amod right,panel
R5506 T7322 T7317 punct ),panel
R5507 T7323 T7287 punct .,are
R5508 T7325 T7326 det The,strains
R5509 T7326 T7328 nsubjpass strains,listed
R5510 T7327 T7326 compound BXD,strains
R5511 T7329 T7328 auxpass are,listed
R5512 T7330 T7328 prep in,listed
R5513 T7331 T7330 pobj order,in
R5514 T7332 T7328 prep from,listed
R5515 T7333 T7332 amod least,from
R5516 T7334 T7332 prep to,from
R5517 T7335 T7334 amod most,to
R5518 T7336 T7332 amod sensitive,from
R5519 T7337 T7336 prep to,sensitive
R5520 T7338 T7339 nummod 1,mM
R5521 T7339 T7340 compound mM,QHCL
R5522 T7340 T7337 pobj QHCL,to
R5523 T7341 T7328 punct .,listed
R5524 T7344 T7345 compound Mean,ratios
R5525 T7346 T7345 compound lick,ratios
R5526 T7347 T7345 prep for,ratios
R5527 T7348 T7349 nmod B6,mice
R5528 T7349 T7347 pobj mice,for
R5529 T7350 T7348 punct ", ",B6
R5530 T7351 T7348 conj D2,B6
R5531 T7352 T7351 cc and,D2
R5532 T7353 T7351 conj BXD,D2
R5533 T7354 T7345 punct .,ratios
R41 T175 T172 cc if,Some
R42 T176 T175 neg not,if
R43 T177 T172 conj all,Some
R1 T128 T125 prep at,Haplotypes
R2 T129 T130 det the,locus
R3 T130 T128 pobj locus,at
R5 T132 T130 prep on,locus
R6 T133 T134 amod distal,chromosome
R7 T134 T132 pobj chromosome,on
R8 T135 T134 nummod 6,chromosome
R9 T136 T126 prep with,vary
R10 T137 T138 compound quinine,taste
R11 T138 T139 compound taste,sensitivity
R12 T139 T136 pobj sensitivity,with
R13 T140 T126 prep in,vary
R14 T141 T142 amod inbred,mice
R15 T142 T140 pobj mice,in
R16 T147 T148 det The,detection
R17 T148 T149 nsubjpass detection,thought
R18 T150 T148 prep of,detection
R19 T151 T152 amod bitter,tasting
R20 T152 T154 amod tasting,compounds
R22 T154 T150 pobj compounds,of
R23 T155 T148 prep by,detection
R24 T156 T157 det the,system
R25 T157 T155 pobj system,by
R27 T159 T149 auxpass is,thought
R28 T160 T161 aux to,alert
R29 T161 T149 xcomp alert,thought
R30 T162 T161 dobj animals,alert
R31 T163 T161 prep to,alert
R32 T164 T165 det the,presence
R33 T165 T163 pobj presence,to
R34 T166 T165 prep of,presence
R35 T167 T168 advmod potentially,toxic
R36 T168 T169 amod toxic,food
R37 T169 T166 pobj food,of
R38 T170 T149 punct .,thought
R39 T172 T173 nsubj Some,activate
R40 T174 T172 punct ", ",Some
R44 T178 T177 punct ", ",all
R45 T179 T180 amod bitter,stimuli
R46 T180 T177 conj stimuli,all
R47 T181 T182 amod specific,receptors
R48 T182 T173 dobj receptors,activate
R50 T184 T182 punct ", ",receptors
R51 T185 T186 det the,T2Rs
R52 T186 T182 appos T2Rs,receptors
R53 T187 T182 punct ", ",receptors
R54 T188 T189 dep which,expressed
R55 T189 T182 relcl expressed,receptors
R57 T191 T189 prep in,expressed
R58 T192 T191 pobj subsets,in
R59 T193 T192 prep of,subsets
R60 T194 T195 compound taste,cells
R61 T195 T193 pobj cells,of
R63 T197 T195 prep on,cells
R64 T198 T199 det the,tongue
R65 T199 T197 pobj tongue,on
R66 T200 T199 cc and,tongue
R67 T201 T199 conj palate,tongue
R68 T202 T173 punct .,activate
R69 T204 T205 advmod However,is
R70 T206 T205 punct ", ",is
R71 T207 T205 expl there,is
R72 T208 T205 attr evidence,is
R73 T209 T208 prep for,evidence
R74 T210 T211 preconj both,mechanisms
R75 T211 T209 pobj mechanisms,for
R77 T213 T211 amod dependent,mechanisms
R78 T214 T213 punct -,dependent
R83 T219 T211 prep for,mechanisms
R84 T220 T221 det a,number
R85 T221 T219 pobj number,for
R86 T222 T221 prep of,number
R87 T223 T224 amod bitter,stimuli
R88 T224 T222 pobj stimuli,of
R89 T225 T221 punct ", ",number
R90 T226 T221 prep including,number
R91 T227 T228 compound quinine,hydrochloride
R92 T228 T226 pobj hydrochloride,including
R93 T229 T228 punct (,hydrochloride
R94 T230 T228 appos QHCl,hydrochloride
R95 T231 T228 punct ),hydrochloride
R96 T232 T228 cc and,hydrochloride
R97 T233 T234 compound denatonium,benzoate
R98 T234 T228 conj benzoate,hydrochloride
R99 T235 T234 punct (,benzoate
R100 T236 T234 appos DB,benzoate
R101 T237 T234 punct ),benzoate
R102 T238 T205 punct .,is
R103 T242 T243 nsubj We,used
R104 T244 T245 amod brief,access
R105 T245 T247 nmod access,testing
R107 T247 T243 dobj testing,used
R110 T250 T247 prep of,testing
R111 T251 T252 nmod BXD,Ty
R112 T252 T254 nmod Ty,strains
R114 T254 T250 pobj strains,of
R121 T261 T262 aux to,map
R122 T262 T243 advcl map,used
R123 T263 T264 det the,locus
R124 T264 T262 dobj locus,map
R128 T268 T264 punct (,locus
R129 T269 T264 appos QTL,locus
R130 T270 T262 punct ),map
R131 T271 T262 prep for,map
R132 T272 T273 compound taste,sensitivity
R133 T273 T271 pobj sensitivity,for
R134 T274 T273 prep to,sensitivity
R135 T275 T274 pobj QHCl,to
R136 T276 T243 punct .,used
R137 T278 T279 det This,QTL
R138 T279 T280 nsubjpass QTL,restricted
R139 T281 T280 auxpass is,restricted
R140 T282 T280 prep to,restricted
R141 T283 T284 det a,interval
R142 T284 T282 pobj interval,to
R146 T288 T284 prep on,interval
R147 T289 T288 pobj chromosome,on
R148 T290 T289 nummod 6,chromosome
R149 T291 T292 dep that,includes
R150 T292 T284 relcl includes,interval
R151 T293 T294 nummod 24,genes
R152 T294 T292 dobj genes,includes
R153 T295 T294 acl encoding,genes
R154 T296 T295 dobj T2Rs,encoding
R155 T297 T296 punct (,T2Rs
R156 T298 T296 appos Tas2rs,T2Rs
R157 T299 T280 punct ),restricted
R158 T300 T280 punct .,restricted
R159 T302 T303 nsubj Tas2rs,display
R160 T303 T307 ccomp display,are
R164 T308 T303 prep in,display
R165 T309 T308 amod total,in
R166 T310 T311 nummod 307,polymorphisms
R167 T311 T303 dobj polymorphisms,display
R172 T316 T311 punct (,polymorphisms
R173 T317 T311 appos SNPs,polymorphisms
R174 T318 T311 punct ),polymorphisms
R175 T319 T311 prep between,polymorphisms
R176 T320 T321 det the,strains
R177 T321 T319 pobj strains,between
R180 T324 T321 nmod Ty,strains
R181 T325 T324 punct /,Ty
R184 T328 T321 punct ", ",strains
R185 T329 T330 compound C57BL,6J
R186 T330 T321 conj 6J,strains
R188 T332 T333 punct (,sensitive
R189 T333 T330 parataxis sensitive,6J
R192 T336 T333 punct ),sensitive
R193 T337 T330 cc and,6J
R194 T338 T339 compound DBA,2J
R195 T339 T330 conj 2J,6J
R197 T341 T342 punct (,insensitive
R198 T342 T339 parataxis insensitive,2J
R200 T344 T342 punct ),insensitive
R201 T345 T307 punct ;,are
R202 T346 T347 advmod approximately,50
R203 T347 T348 nummod 50,%
R204 T348 T307 nsubj %,are
R205 T349 T348 prep of,%
R206 T350 T351 det these,mutations
R207 T351 T349 pobj mutations,of
R208 T352 T307 acomp silent,are
R209 T353 T307 punct .,are
R210 T355 T356 amod Individual,lines
R211 T356 T358 nsubj lines,contain
R213 T359 T358 advmod exclusively,contain
R214 T360 T361 preconj either,6J
R215 T361 T364 nmod 6J,alleles
R218 T364 T358 dobj alleles,contain
R221 T367 T361 conj 2J,6J
R222 T368 T367 punct /,2J
R224 T370 T358 prep at,contain
R225 T371 T372 det this,locus
R226 T372 T370 pobj locus,at
R227 T373 T358 punct ", ",contain
R228 T374 T358 cc and,contain
R229 T375 T376 amod RI,lines
R230 T376 T377 nsubj lines,are
R231 T377 T358 conj are,contain
R234 T380 T382 compound 6J,alleles
R235 T381 T380 punct /,6J
R236 T382 T378 dobj alleles,containing
R237 T383 T382 compound Tas2r,alleles
R238 T384 T385 advmod more,sensitive
R239 T385 T377 acomp sensitive,are
R240 T386 T385 prep to,sensitive
R241 T387 T386 pobj QHCl,to
R242 T388 T389 mark than,are
R243 T389 T385 advcl are,sensitive
R244 T390 T389 nsubj lines,are
R245 T391 T390 acl containing,lines
R246 T392 T393 compound DBA,2J
R247 T393 T395 compound 2J,alleles
R249 T395 T391 dobj alleles,containing
R250 T396 T377 punct .,are
R251 T398 T399 advmod Thus,comprises
R252 T400 T399 punct ", ",comprises
R253 T401 T402 det the,cluster
R254 T402 T399 nsubj cluster,comprises
R257 T405 T406 det a,haplotype
R258 T406 T399 dobj haplotype,comprises
R260 T408 T409 dep that,correlates
R261 T409 T406 relcl correlates,haplotype
R262 T410 T409 prep with,correlates
R263 T411 T412 compound quinine,taster
R264 T412 T413 compound taster,status
R265 T413 T410 pobj status,with
R266 T414 T399 punct .,comprises
R267 T418 T419 det These,studies
R268 T419 T420 nsubj studies,indicate
R269 T421 T419 punct ", ",studies
R270 T422 T423 det the,first
R271 T423 T419 appos first,studies
R272 T424 T423 acl using,first
R273 T425 T426 det a,assay
R274 T426 T424 dobj assay,using
R276 T428 T426 amod salient,assay
R277 T429 T428 punct -,salient
R278 T430 T431 aux to,map
R279 T431 T424 advcl map,using
R280 T432 T433 det the,QTL
R281 T433 T431 dobj QTL,map
R283 T435 T433 prep for,QTL
R284 T436 T437 compound quinine,taste
R285 T437 T435 pobj taste,for
R286 T438 T420 punct ", ",indicate
R287 T439 T440 mark that,is
R288 T440 T420 ccomp is,indicate
R290 T442 T440 nsubj cascade,is
R291 T443 T444 npadvmod T2R,dependent
R293 T445 T444 punct -,dependent
R294 T446 T442 compound transduction,cascade
R295 T447 T440 acomp responsible,is
R296 T448 T447 prep for,responsible
R297 T449 T450 det the,majority
R298 T450 T448 pobj majority,for
R299 T451 T450 prep of,majority
R300 T452 T453 compound strain,variance
R301 T453 T451 pobj variance,of
R302 T454 T453 prep in,variance
R303 T455 T456 compound quinine,taste
R304 T456 T457 compound taste,sensitivity
R305 T457 T454 pobj sensitivity,in
R306 T458 T420 punct .,indicate
R307 T460 T461 advmod Furthermore,suggest
R308 T462 T461 punct ", ",suggest
R309 T463 T464 det the,number
R310 T464 T461 nsubj number,suggest
R312 T466 T464 prep of,number
R313 T467 T466 pobj polymorphisms,of
R314 T468 T467 prep within,polymorphisms
R315 T469 T470 amod coding,exons
R316 T470 T468 pobj exons,within
R317 T471 T470 prep of,exons
R318 T472 T473 det the,cluster
R319 T473 T471 pobj cluster,of
R321 T475 T464 punct ", ",number
R322 T476 T464 acl coupled,number
R323 T477 T476 prep with,coupled
R324 T478 T477 pobj evidence,with
R325 T479 T480 mark that,exhibit
R326 T480 T478 acl exhibit,evidence
R329 T483 T484 advmod largely,similar
R330 T484 T485 amod similar,phenotypes
R331 T485 T480 dobj phenotypes,exhibit
R334 T488 T461 punct ", ",suggest
R335 T489 T490 mark that,are
R336 T490 T461 ccomp are,suggest
R339 T493 T494 advmod quite,tolerant
R340 T494 T490 acomp tolerant,are
R341 T495 T494 prep to,tolerant
R342 T496 T495 pobj variation,to
R343 T497 T461 punct .,suggest
R345 T125 T126 nsubj Haplotypes,vary
R359 T726 T727 nsubj Animals,use
R360 T728 T729 det the,system
R361 T729 T727 dobj system,use
R362 T730 T729 amod gustatory,system
R363 T731 T732 aux to,provide
R364 T732 T727 advcl provide,use
R365 T733 T732 dobj information,provide
R366 T734 T733 prep about,information
R367 T735 T736 compound food,quality
R368 T736 T734 pobj quality,about
R369 T737 T727 punct .,use
R370 T739 T740 prep For,have
R371 T741 T739 pobj example,For
R372 T742 T740 punct ", ",have
R373 T743 T744 amod sweet,tasting
R374 T744 T746 amod tasting,foods
R375 T745 T744 punct -,tasting
R376 T746 T740 nsubj foods,have
R377 T747 T740 aux may,have
R378 T748 T749 det a,content
R379 T749 T740 dobj content,have
R380 T750 T749 amod high,content
R381 T751 T749 amod caloric,content
R382 T752 T740 cc and,have
R383 T753 T754 auxpass are,preferred
R384 T754 T740 conj preferred,have
R385 T755 T740 punct ", ",have
R386 T756 T757 mark while,contain
R387 T757 T740 advcl contain,have
R388 T758 T759 amod bitter,tasting
R389 T759 T761 amod tasting,foods
R390 T760 T759 punct -,tasting
R391 T761 T757 nsubj foods,contain
R392 T762 T757 advmod often,contain
R393 T763 T764 amod toxic,substances
R394 T764 T757 dobj substances,contain
R395 T765 T757 punct ", ",contain
R396 T766 T757 cc and,contain
R397 T767 T768 auxpass are,avoided
R398 T768 T757 conj avoided,contain
R399 T769 T768 advmod generally,avoided
R400 T770 T740 punct .,have
R401 T772 T773 nummod Two,families
R402 T773 T774 nsubjpass families,implicated
R403 T775 T773 prep of,families
R404 T776 T777 compound G,protein
R405 T777 T778 npadvmod protein,coupled
R406 T778 T780 amod coupled,receptors
R407 T779 T778 punct -,coupled
R408 T780 T775 pobj receptors,of
R409 T781 T780 punct (,receptors
R410 T782 T780 appos GPCRs,receptors
R411 T783 T773 punct ),families
R412 T784 T773 acl expressed,families
R413 T785 T784 prep in,expressed
R414 T786 T785 pobj subpopulations,in
R415 T787 T786 prep of,subpopulations
R416 T788 T789 compound taste,cells
R417 T789 T787 pobj cells,of
R418 T790 T789 compound receptor,cells
R419 T791 T789 punct (,cells
R420 T792 T789 appos TRCs,cells
R421 T793 T789 punct ),cells
R422 T794 T789 prep of,cells
R423 T795 T796 det the,epithelium
R424 T796 T794 pobj epithelium,of
R425 T797 T796 amod gustatory,epithelium
R426 T798 T774 aux have,implicated
R427 T799 T774 auxpass been,implicated
R428 T800 T774 prep in,implicated
R429 T801 T802 det the,detection
R430 T802 T800 pobj detection,in
R431 T803 T802 cc and,detection
R432 T804 T802 conj transduction,detection
R433 T805 T802 prep of,detection
R434 T806 T807 amod sweet,taste
R435 T807 T805 pobj taste,of
R436 T808 T806 punct ", ",sweet
R437 T809 T806 conj bitter,sweet
R438 T810 T809 cc and,bitter
R439 T811 T809 conj umami,bitter
R440 T812 T813 punct (,glutamate
R441 T813 T811 parataxis glutamate,umami
R442 T814 T813 advmod i.e.,glutamate
R443 T815 T813 punct ", ",glutamate
R444 T816 T813 punct ),glutamate
R445 T817 T774 punct : ,implicated
R446 T818 T774 dobj T1Rs,implicated
R447 T819 T818 prep for,T1Rs
R448 T820 T821 amod sweet,stimuli
R449 T821 T819 pobj stimuli,for
R450 T822 T820 punct -,sweet
R451 T823 T820 cc and,sweet
R452 T824 T825 amod umami,tasting
R453 T825 T820 conj tasting,sweet
R454 T826 T825 punct -,tasting
R455 T827 T828 punct [,1
R456 T828 T818 parataxis 1,T1Rs
R457 T829 T830 punct -,8
R458 T830 T828 prep 8,1
R459 T831 T828 punct ],1
R460 T832 T818 punct ", ",T1Rs
R461 T833 T818 cc and,T1Rs
R462 T834 T818 conj T2Rs,T1Rs
R463 T835 T834 prep for,T2Rs
R464 T836 T837 amod bitter,tasting
R465 T837 T839 amod tasting,compounds
R466 T838 T837 punct -,tasting
R467 T839 T835 pobj compounds,for
R468 T840 T841 punct [,9
R469 T841 T834 parataxis 9,T2Rs
R470 T842 T843 punct -,11
R471 T843 T841 prep 11,9
R472 T844 T841 punct ],9
R473 T845 T774 punct .,implicated
R474 T847 T848 det The,genes
R475 T848 T849 nsubjpass genes,identified
R476 T850 T851 dep that,encode
R477 T851 T848 relcl encode,genes
R478 T852 T851 dobj T2Rs,encode
R479 T853 T848 punct ", ",genes
R480 T854 T855 det the,Tas2rs
R481 T855 T848 appos Tas2rs,genes
R482 T856 T849 punct ", ",identified
R483 T857 T849 auxpass were,identified
R484 T858 T849 advmod first,identified
R485 T859 T849 agent by,identified
R486 T860 T861 compound database,mining
R487 T861 T859 pobj mining,by
R488 T862 T861 prep of,mining
R489 T863 T864 amod mammalian,genomes
R490 T864 T862 pobj genomes,of
R491 T865 T864 prep near,genomes
R492 T866 T867 amod chromosomal,markers
R493 T867 T865 pobj markers,near
R494 T868 T869 advmod previously,linked
R495 T869 T867 acl linked,markers
R496 T870 T869 prep to,linked
R497 T871 T870 pobj differences,to
R498 T872 T871 prep in,differences
R499 T873 T874 amod bitter,taste
R500 T874 T875 compound taste,sensitivity
R501 T875 T872 pobj sensitivity,in
R502 T876 T877 punct [,11
R503 T877 T869 parataxis 11,linked
R504 T878 T877 dep 9,11
R505 T879 T877 punct ",",11
R506 T880 T881 punct -,18
R507 T881 T877 prep 18,11
R508 T882 T877 punct ],11
R509 T883 T849 punct .,identified
R510 T885 T886 prep In,lie
R511 T887 T885 pobj mice,In
R512 T888 T886 punct ", ",lie
R513 T889 T890 det the,majority
R514 T890 T886 nsubj majority,lie
R515 T891 T890 prep of,majority
R516 T892 T891 pobj Tas2rs,of
R517 T893 T886 prep within,lie
R518 T894 T895 det a,cluster
R519 T895 T893 pobj cluster,within
R520 T896 T895 amod single,cluster
R521 T897 T895 prep on,cluster
R522 T898 T899 amod distal,chromosome
R523 T899 T897 pobj chromosome,on
R524 T900 T899 nummod 6,chromosome
R525 T901 T886 punct .,lie
R526 T903 T904 compound Thirty,three
R527 T904 T906 nummod three,Tas2rs
R528 T905 T904 punct -,three
R529 T906 T908 nsubjpass Tas2rs,identified
R530 T907 T906 amod human,Tas2rs
R531 T909 T906 punct (,Tas2rs
R532 T910 T906 prep including,Tas2rs
R533 T911 T912 nummod 8,pseudogenes
R534 T912 T910 pobj pseudogenes,including
R535 T913 T906 punct ),Tas2rs
R536 T914 T906 cc and,Tas2rs
R537 T915 T916 compound thirty,six
R538 T916 T918 nummod six,Tas2rs
R539 T917 T916 punct -,six
R540 T918 T906 conj Tas2rs,Tas2rs
R541 T919 T918 compound mouse,Tas2rs
R542 T920 T918 punct (,Tas2rs
R543 T921 T918 prep including,Tas2rs
R544 T922 T923 nummod 3,pseudogenes
R545 T923 T921 pobj pseudogenes,including
R546 T924 T923 prep in,pseudogenes
R547 T925 T926 compound C57BL,6J
R548 T926 T928 compound 6J,mice
R549 T927 T926 punct /,6J
R550 T928 T924 pobj mice,in
R551 T929 T918 punct ),Tas2rs
R552 T930 T908 aux have,identified
R553 T931 T908 auxpass been,identified
R554 T932 T933 punct [,19
R555 T933 T908 parataxis 19,identified
R556 T934 T933 nummod 9,19
R557 T935 T933 punct ",",19
R558 T936 T933 nummod 11,19
R559 T937 T933 punct ",",19
R560 T938 T933 punct ],19
R561 T939 T908 punct ", ",identified
R562 T940 T908 cc and,identified
R563 T941 T942 nsubj several,respond
R564 T942 T908 conj respond,identified
R565 T943 T941 prep of,several
R566 T944 T943 pobj these,of
R567 T945 T942 prep to,respond
R568 T946 T947 amod particular,stimuli
R569 T947 T945 pobj stimuli,to
R570 T948 T947 amod bitter,stimuli
R571 T949 T942 prep in,respond
R572 T950 T951 amod heterologous,assays
R573 T951 T949 pobj assays,in
R574 T952 T951 compound expression,assays
R575 T953 T954 punct [,20
R576 T954 T942 parataxis 20,respond
R577 T955 T954 dep 10,20
R578 T956 T954 punct ",",20
R579 T957 T958 punct -,23
R580 T958 T954 prep 23,20
R581 T959 T954 punct ],20
R582 T960 T942 punct ", ",respond
R583 T961 T942 cc or,respond
R584 T962 T942 conj represent,respond
R585 T963 T964 det a,gene
R586 T964 T962 dobj gene,represent
R587 T965 T964 amod strong,gene
R588 T966 T964 compound candidate,gene
R589 T967 T964 prep for,gene
R590 T968 T969 det a,trait
R591 T969 T967 pobj trait,for
R592 T970 T969 amod specific,trait
R593 T971 T972 amod bitter,taste
R594 T972 T969 nmod taste,trait
R595 T973 T969 amod quantitative,trait
R596 T974 T975 punct [,25
R597 T975 T962 parataxis 25,represent
R598 T976 T975 nummod 18,25
R599 T977 T975 punct ",",25
R600 T978 T975 nummod 24,25
R601 T979 T975 punct ",",25
R602 T980 T975 punct ],25
R603 T981 T942 punct .,respond
R604 T983 T984 amod Several,loci
R605 T984 T987 nsubjpass loci,identified
R606 T985 T984 amod quantitative,loci
R607 T986 T984 compound trait,loci
R608 T988 T984 punct (,loci
R609 T989 T984 appos QTL,loci
R610 T990 T987 punct ),identified
R611 T991 T987 aux have,identified
R612 T992 T987 auxpass been,identified
R613 T993 T994 dep that,influence
R614 T994 T987 ccomp influence,identified
R615 T995 T996 nummod two,bottle
R616 T996 T998 compound bottle,intake
R617 T997 T996 punct -,bottle
R618 T998 T994 dobj intake,influence
R619 T999 T998 prep of,intake
R620 T1000 T1001 amod bitter,stimuli
R621 T1001 T999 pobj stimuli,of
R622 T1002 T998 prep in,intake
R623 T1003 T1004 det the,mouse
R624 T1004 T1002 pobj mouse,in
R625 T1005 T987 punct ", ",identified
R626 T1006 T987 prep including,identified
R627 T1007 T1006 pobj loci,including
R628 T1008 T1007 prep for,loci
R629 T1009 T1010 nmod quinine,sensitivity
R630 T1010 T1008 pobj sensitivity,for
R631 T1011 T1009 punct (,quinine
R632 T1012 T1009 appos Qui,quinine
R633 T1013 T1009 punct ),quinine
R634 T1014 T1015 punct [,26
R635 T1015 T1009 parataxis 26,quinine
R636 T1016 T1015 nummod 12,26
R637 T1017 T1015 punct ",",26
R638 T1018 T1015 nummod 16,26
R639 T1019 T1015 punct ",",26
R640 T1020 T1015 punct ],26
R641 T1021 T1009 punct ", ",quinine
R642 T1022 T1009 conj cyclohexamide,quinine
R643 T1023 T1022 punct (,cyclohexamide
R644 T1024 T1022 appos Cyx,cyclohexamide
R645 T1025 T1022 punct ),cyclohexamide
R646 T1026 T1027 punct [,13
R647 T1027 T1022 parataxis 13,cyclohexamide
R648 T1028 T1027 punct ],13
R649 T1029 T1022 cc and,cyclohexamide
R650 T1030 T1031 compound sucrose,octaacetate
R651 T1031 T1022 conj octaacetate,cyclohexamide
R652 T1032 T1031 punct (,octaacetate
R653 T1033 T1031 appos Soa,octaacetate
R654 T1034 T1031 punct ),octaacetate
R655 T1035 T1036 punct [,17
R656 T1036 T1031 parataxis 17,octaacetate
R657 T1037 T1036 nummod 14,17
R658 T1038 T1036 punct ",",17
R659 T1039 T1036 nummod 15,17
R660 T1040 T1036 punct ",",17
R661 T1041 T1036 punct ],17
R662 T1042 T987 punct .,identified
R663 T1044 T1045 nsubj Each,map
R664 T1046 T1044 prep of,Each
R665 T1047 T1048 det these,QTL
R666 T1048 T1046 pobj QTL,of
R667 T1049 T1045 prep to,map
R668 T1050 T1051 nmod mouse,chromosome
R669 T1051 T1049 pobj chromosome,to
R670 T1052 T1051 amod distal,chromosome
R671 T1053 T1051 nummod 6,chromosome
R672 T1054 T1045 cc and,map
R673 T1055 T1056 auxpass are,linked
R674 T1056 T1045 conj linked,map
R675 T1057 T1056 prep to,linked
R676 T1058 T1059 det the,D6Mit13
R677 T1059 T1057 pobj D6Mit13,to
R678 T1060 T1059 compound marker,D6Mit13
R679 T1061 T1059 punct ", ",D6Mit13
R680 T1062 T1063 dep which,lies
R681 T1063 T1059 relcl lies,D6Mit13
R682 T1064 T1063 prep within,lies
R683 T1065 T1066 det a,cluster
R684 T1066 T1064 pobj cluster,within
R685 T1067 T1066 prep of,cluster
R686 T1068 T1069 nummod 24,Tas2rs
R687 T1069 T1067 pobj Tas2rs,of
R688 T1070 T1069 amod intact,Tas2rs
R689 T1071 T1063 prep in,lies
R690 T1072 T1073 det the,genome
R691 T1073 T1071 pobj genome,in
R692 T1074 T1073 nmod C57BL,genome
R693 T1075 T1074 punct /,C57BL
R694 T1076 T1074 nummod 6,C57BL
R695 T1077 T1078 punct (,28
R696 T1078 T1063 parataxis 28,lies
R697 T1079 T1078 advmod e.g.,28
R698 T1080 T1078 punct ", ",28
R699 T1081 T1078 punct [,28
R700 T1082 T1078 nummod 16,28
R701 T1083 T1078 punct ",",28
R702 T1084 T1078 nummod 27,28
R703 T1085 T1078 punct ",",28
R704 T1086 T1078 punct ],28
R705 T1087 T1078 punct ),28
R706 T1088 T1045 punct .,map
R707 T1090 T1091 advmod However,remains
R708 T1092 T1091 punct ", ",remains
R709 T1093 T1094 det the,interpretation
R710 T1094 T1091 nsubj interpretation,remains
R711 T1095 T1094 prep of,interpretation
R712 T1096 T1097 det these,studies
R713 T1097 T1095 pobj studies,of
R714 T1098 T1091 acomp problematic,remains
R715 T1099 T1091 prep for,remains
R716 T1100 T1101 nummod two,reasons
R717 T1101 T1099 pobj reasons,for
R718 T1102 T1091 punct .,remains
R719 T1104 T1105 advmod First,permit
R720 T1106 T1105 punct ", ",permit
R721 T1107 T1108 det the,density
R722 T1108 T1105 nsubj density,permit
R723 T1109 T1108 prep of,density
R724 T1110 T1111 amod chromosomal,markers
R725 T1111 T1109 pobj markers,of
R726 T1112 T1108 cc and,density
R727 T1113 T1108 conj number,density
R728 T1114 T1113 prep of,number
R729 T1115 T1116 amod recombinant,inbred
R730 T1116 T1117 amod inbred,RI
R731 T1117 T1119 amod RI,strains
R732 T1118 T1117 punct (,RI
R733 T1119 T1114 pobj strains,of
R734 T1120 T1119 punct ),strains
R735 T1121 T1113 acl used,number
R736 T1122 T1121 prep in,used
R737 T1123 T1124 det these,studies
R738 T1124 T1122 pobj studies,in
R739 T1125 T1124 amod earlier,studies
R740 T1126 T1105 aux did,permit
R741 T1127 T1105 neg not,permit
R742 T1128 T1129 det the,definition
R743 T1129 T1105 dobj definition,permit
R744 T1130 T1129 amod physical,definition
R745 T1131 T1129 prep of,definition
R746 T1132 T1133 det the,intervals
R747 T1133 T1131 pobj intervals,of
R748 T1134 T1133 acl containing,intervals
R749 T1135 T1136 det each,QTL
R750 T1136 T1134 dobj QTL,containing
R751 T1137 T1105 punct .,permit
R752 T1139 T1140 advmod Second,relied
R753 T1141 T1140 punct ", ",relied
R754 T1142 T1143 det these,attempts
R755 T1143 T1140 nsubj attempts,relied
R756 T1144 T1143 amod previous,attempts
R757 T1145 T1146 aux to,map
R758 T1146 T1143 acl map,attempts
R759 T1147 T1148 amod bitter,taste
R760 T1148 T1149 compound taste,QTLs
R761 T1149 T1146 dobj QTLs,map
R762 T1150 T1140 prep on,relied
R763 T1151 T1152 amod behavioral,assays
R764 T1152 T1150 pobj assays,on
R765 T1153 T1154 dep that,measured
R766 T1154 T1152 relcl measured,assays
R767 T1155 T1154 dobj consumption,measured
R768 T1156 T1140 punct ", ",relied
R769 T1157 T1140 cc and,relied
R770 T1158 T1140 conj were,relied
R771 T1159 T1158 advmod thus,were
R772 T1160 T1158 acomp susceptible,were
R773 T1161 T1160 prep to,susceptible
R774 T1162 T1161 pobj contributions,to
R775 T1163 T1162 prep of,contributions
R776 T1164 T1165 amod post-ingestive,effects
R777 T1165 T1163 pobj effects,of
R778 T1166 T1167 amod such,as
R779 T1167 T1165 prep as,effects
R780 T1168 T1167 pobj toxicity,as
R781 T1169 T1140 punct .,relied
R782 T1171 T1172 mark As,shown
R783 T1172 T1175 advcl shown,confound
R784 T1173 T1172 nsubj we,shown
R785 T1174 T1172 aux have,shown
R786 T1176 T1172 advmod previously,shown
R787 T1177 T1175 punct ", ",confound
R788 T1178 T1179 amod such,effects
R789 T1179 T1175 nsubj effects,confound
R790 T1180 T1175 aux can,confound
R791 T1181 T1182 det the,quantification
R792 T1182 T1175 dobj quantification,confound
R793 T1183 T1182 prep of,quantification
R794 T1184 T1185 amod bitter,taste
R795 T1185 T1186 compound taste,behaviors
R796 T1186 T1183 pobj behaviors,of
R797 T1187 T1188 punct [,29
R798 T1188 T1175 parataxis 29,confound
R799 T1189 T1188 punct ],29
R800 T1190 T1175 punct .,confound
R801 T1192 T1193 advmod Therefore,remain
R802 T1194 T1193 punct ", ",remain
R803 T1195 T1196 det the,relevance
R804 T1196 T1193 nsubj relevance,remain
R805 T1197 T1196 cc and,relevance
R806 T1198 T1197 punct /,and
R807 T1199 T1197 cc or,and
R808 T1200 T1196 conj contribution,relevance
R809 T1201 T1196 prep of,relevance
R810 T1202 T1203 det the,QTLs
R811 T1203 T1201 pobj QTLs,of
R812 T1204 T1203 amod aforementioned,QTLs
R813 T1205 T1196 prep to,relevance
R814 T1206 T1207 amod bitter,taste
R815 T1207 T1205 pobj taste,to
R816 T1208 T1193 acomp unclear,remain
R817 T1209 T1193 punct .,remain
R818 T1211 T1212 advmod Furthermore,suggested
R819 T1213 T1212 punct ", ",suggested
R820 T1214 T1215 det a,number
R821 T1215 T1212 nsubj number,suggested
R822 T1216 T1215 prep of,number
R823 T1217 T1218 amod physiological,studies
R824 T1218 T1216 pobj studies,of
R825 T1219 T1212 aux have,suggested
R826 T1220 T1221 mark that,stimulate
R827 T1221 T1212 ccomp stimulate,suggested
R828 T1222 T1223 det the,transduction
R829 T1223 T1221 nsubj transduction,stimulate
R830 T1224 T1223 prep of,transduction
R831 T1225 T1226 det some,compounds
R832 T1226 T1224 pobj compounds,of
R833 T1227 T1226 amod amphiphilic,compounds
R834 T1228 T1226 amod bitter,compounds
R835 T1229 T1226 punct ", ",compounds
R836 T1230 T1231 amod such,as
R837 T1231 T1226 prep as,compounds
R838 T1232 T1231 pobj quinine,as
R839 T1233 T1232 cc and,quinine
R840 T1234 T1235 compound denatonium,benzoate
R841 T1235 T1232 conj benzoate,quinine
R842 T1236 T1221 punct ", ",stimulate
R843 T1237 T1221 aux may,stimulate
R844 T1238 T1239 compound taste,receptor
R845 T1239 T1240 compound receptor,cells
R846 T1240 T1221 dobj cells,stimulate
R847 T1241 T1221 advmod independently,stimulate
R848 T1242 T1241 prep of,independently
R849 T1243 T1242 pobj GPCRs,of
R850 T1244 T1245 punct (,30
R851 T1245 T1221 parataxis 30,stimulate
R852 T1246 T1245 advmod e.g.,30
R853 T1247 T1245 punct [,30
R854 T1248 T1245 punct ],30
R855 T1249 T1245 punct ),30
R856 T1250 T1212 punct .,suggested
R857 T1252 T1253 nsubj Quinine,activate
R858 T1253 T1256 ccomp activate,inhibits
R859 T1254 T1253 aux may,activate
R860 T1255 T1253 advmod directly,activate
R861 T1257 T1258 compound G,proteins
R862 T1258 T1253 dobj proteins,activate
R863 T1259 T1253 punct ", ",activate
R864 T1260 T1253 cc and,activate
R865 T1261 T1262 preconj both,quinine
R866 T1262 T1263 nsubj quinine,block
R867 T1263 T1253 conj block,activate
R868 T1264 T1262 cc and,quinine
R869 T1265 T1262 conj denatonium,quinine
R870 T1266 T1263 aux can,block
R871 T1267 T1268 nmod K,channels
R872 T1268 T1263 dobj channels,block
R873 T1269 T1267 punct +,K
R874 T1270 T1271 punct [,31
R875 T1271 T1263 parataxis 31,block
R876 T1272 T1273 punct -,36
R877 T1273 T1271 prep 36,31
R878 T1274 T1271 punct ],31
R879 T1275 T1256 punct ;,inhibits
R880 T1276 T1256 nsubj caffeine,inhibits
R881 T1277 T1276 punct ", ",caffeine
R882 T1278 T1279 det another,substance
R883 T1279 T1276 appos substance,caffeine
R884 T1280 T1281 amod bitter,tasting
R885 T1281 T1279 amod tasting,substance
R886 T1282 T1281 punct -,tasting
R887 T1283 T1256 punct ", ",inhibits
R888 T1284 T1256 advmod directly,inhibits
R889 T1285 T1286 amod intracellular,phosphodiesterase
R890 T1286 T1256 dobj phosphodiesterase,inhibits
R891 T1287 T1288 punct [,33
R892 T1288 T1256 parataxis 33,inhibits
R893 T1289 T1288 punct ],33
R894 T1290 T1256 punct .,inhibits
R895 T1292 T1293 advmod However,are
R896 T1294 T1293 punct ", ",are
R897 T1295 T1296 det the,contributions
R898 T1296 T1293 nsubj contributions,are
R899 T1297 T1296 amod relative,contributions
R900 T1298 T1296 prep of,contributions
R901 T1299 T1300 npadvmod T2R,dependent
R902 T1300 T1302 amod dependent,mechanisms
R903 T1301 T1300 punct -,dependent
R904 T1302 T1298 pobj mechanisms,of
R905 T1303 T1300 cc and,dependent
R906 T1304 T1305 npadvmod T2R,independent
R907 T1305 T1300 conj independent,dependent
R908 T1306 T1305 punct -,independent
R909 T1307 T1296 prep to,contributions
R910 T1308 T1309 det the,detection
R911 T1309 T1307 pobj detection,to
R912 T1310 T1309 prep of,detection
R913 T1311 T1312 det these,stimuli
R914 T1312 T1310 pobj stimuli,of
R915 T1313 T1312 amod bitter,stimuli
R916 T1314 T1293 acomp unknown,are
R917 T1315 T1293 punct .,are
R918 T1317 T1318 advmod Here,use
R919 T1319 T1318 nsubj we,use
R920 T1320 T1321 det a,test
R921 T1321 T1318 dobj test,use
R922 T1322 T1323 npadvmod taste,salient
R923 T1323 T1321 amod salient,test
R924 T1324 T1323 punct -,salient
R925 T1325 T1326 amod brief,access
R926 T1326 T1321 compound access,test
R927 T1327 T1326 punct -,access
R928 T1328 T1321 compound lick,test
R929 T1329 T1330 punct [,37
R930 T1330 T1321 parataxis 37,test
R931 T1331 T1330 nummod 29,37
R932 T1332 T1330 punct ",",37
R933 T1333 T1330 punct ],37
R934 T1334 T1335 aux to,measure
R935 T1335 T1318 advcl measure,use
R936 T1336 T1337 compound taste,sensitivities
R937 T1337 T1335 dobj sensitivities,measure
R938 T1338 T1337 prep in,sensitivities
R939 T1339 T1340 nmod C57BL,6J
R940 T1340 T1342 nmod 6J,mice
R941 T1341 T1340 punct /,6J
R942 T1342 T1338 pobj mice,in
R943 T1343 T1340 punct (,6J
R944 T1344 T1340 appos B6,6J
R945 T1345 T1340 punct ),6J
R946 T1346 T1340 punct ", ",6J
R947 T1347 T1348 compound DBA,2J
R948 T1348 T1340 conj 2J,6J
R949 T1349 T1348 punct /,2J
R950 T1350 T1348 punct (,2J
R951 T1351 T1348 appos D2,2J
R952 T1352 T1348 punct ),2J
R953 T1353 T1348 cc and,2J
R954 T1354 T1355 compound BXD,Ty
R955 T1355 T1348 conj Ty,2J
R956 T1356 T1355 punct /,Ty
R957 T1357 T1355 punct (,Ty
R958 T1358 T1355 appos BXD,Ty
R959 T1359 T1355 punct ),Ty
R960 T1360 T1361 amod recombinant,inbred
R961 T1361 T1342 amod inbred,mice
R962 T1362 T1363 punct (,RI
R963 T1363 T1361 parataxis RI,inbred
R964 T1364 T1363 punct ),RI
R965 T1365 T1337 prep to,sensitivities
R966 T1366 T1367 nummod two,stimuli
R967 T1367 T1365 pobj stimuli,to
R968 T1368 T1367 amod bitter,stimuli
R969 T1369 T1367 punct ", ",stimuli
R970 T1370 T1371 compound quinine,hydrochloride
R971 T1371 T1367 appos hydrochloride,stimuli
R972 T1372 T1371 punct (,hydrochloride
R973 T1373 T1371 appos QHCl,hydrochloride
R974 T1374 T1371 punct ),hydrochloride
R975 T1375 T1371 cc and,hydrochloride
R976 T1376 T1377 compound denatonium,benzoate
R977 T1377 T1371 conj benzoate,hydrochloride
R978 T1378 T1377 punct (,benzoate
R979 T1379 T1377 appos DB,benzoate
R980 T1380 T1318 punct ),use
R981 T1381 T1318 punct .,use
R982 T1383 T1384 advcl Using,mapped
R983 T1385 T1386 nummod 17,lines
R984 T1386 T1383 dobj lines,Using
R985 T1387 T1386 compound BXD,lines
R986 T1388 T1389 dep that,genotyped
R987 T1389 T1386 relcl genotyped,lines
R988 T1390 T1389 auxpass were,genotyped
R989 T1391 T1389 prep at,genotyped
R990 T1392 T1393 nummod 762,markers
R991 T1393 T1391 pobj markers,at
R992 T1394 T1393 amod informative,markers
R993 T1395 T1393 amod chromosomal,markers
R994 T1396 T1384 punct ", ",mapped
R995 T1397 T1384 nsubj we,mapped
R996 T1398 T1399 det a,QTL
R997 T1399 T1384 dobj QTL,mapped
R998 T1400 T1399 amod major,QTL
R999 T1401 T1399 prep for,QTL
R1000 T1402 T1403 compound QHCl,taste
R1001 T1403 T1401 pobj taste,for
R1002 T1404 T1384 prep to,mapped
R1003 T1405 T1406 det a,interval
R1004 T1406 T1404 pobj interval,to
R1005 T1407 T1408 punct ~,5
R1006 T1408 T1409 nummod 5,Mb
R1007 T1409 T1406 compound Mb,interval
R1008 T1410 T1406 prep on,interval
R1009 T1411 T1412 amod distal,chromosome
R1010 T1412 T1410 pobj chromosome,on
R1011 T1413 T1412 nummod 6,chromosome
R1012 T1414 T1415 dep that,contains
R1013 T1415 T1406 relcl contains,interval
R1014 T1416 T1417 det all,24
R1015 T1417 T1415 dobj 24,contains
R1016 T1418 T1417 prep of,24
R1017 T1419 T1420 det the,genes
R1018 T1420 T1418 pobj genes,of
R1019 T1421 T1420 compound Tas2r,genes
R1020 T1422 T1420 prep in,genes
R1021 T1423 T1424 det the,cluster
R1022 T1424 T1422 pobj cluster,in
R1023 T1425 T1424 amod distal,cluster
R1024 T1426 T1384 punct .,mapped
R1025 T1428 T1429 nsubj We,analyzed
R1026 T1430 T1431 det the,sequence
R1027 T1431 T1429 dobj sequence,analyzed
R1028 T1432 T1431 prep of,sequence
R1029 T1433 T1434 det each,allele
R1030 T1434 T1432 pobj allele,of
R1031 T1435 T1434 compound Tas2r,allele
R1032 T1436 T1429 prep in,analyzed
R1033 T1437 T1438 det the,strains
R1034 T1438 T1436 pobj strains,in
R1035 T1439 T1438 amod parental,strains
R1036 T1440 T1438 punct (,strains
R1037 T1441 T1438 appos B6,strains
R1038 T1442 T1441 cc and,B6
R1039 T1443 T1441 conj D2,B6
R1040 T1444 T1438 punct ),strains
R1041 T1445 T1438 cc and,strains
R1042 T1446 T1447 nummod 29,lines
R1043 T1447 T1438 conj lines,strains
R1044 T1448 T1447 amod RI,lines
R1045 T1449 T1429 punct .,analyzed
R1046 T1451 T1452 det This,analysis
R1047 T1452 T1453 nsubj analysis,revealed
R1048 T1454 T1455 mark that,are
R1049 T1455 T1453 advcl are,revealed
R1050 T1456 T1457 det all,genes
R1051 T1457 T1455 nsubj genes,are
R1052 T1458 T1457 nummod 24,genes
R1053 T1459 T1455 acomp polymorphic,are
R1054 T1460 T1459 prep between,polymorphic
R1055 T1461 T1462 det the,strains
R1056 T1462 T1460 pobj strains,between
R1057 T1463 T1462 nummod two,strains
R1058 T1464 T1455 punct ", ",are
R1059 T1465 T1455 cc and,are
R1060 T1466 T1467 mark that,comprise
R1061 T1467 T1455 conj comprise,are
R1062 T1468 T1469 det these,Tas2rs
R1063 T1469 T1467 nsubj Tas2rs,comprise
R1064 T1470 T1469 nummod 24,Tas2rs
R1065 T1471 T1472 det a,haplotype
R1066 T1472 T1467 dobj haplotype,comprise
R1067 T1473 T1472 amod single,haplotype
R1068 T1474 T1475 dep that,correlates
R1069 T1475 T1472 relcl correlates,haplotype
R1070 T1476 T1475 prep with,correlates
R1071 T1477 T1478 compound QHCl,taste
R1072 T1478 T1479 compound taste,sensitivity
R1073 T1479 T1476 pobj sensitivity,with
R1074 T1480 T1453 punct .,revealed
R1075 T1522 T1523 compound Taste,testing
R1076 T1525 T1526 amod Previous,efforts
R1077 T1526 T1527 nsubj efforts,utilized
R1078 T1528 T1529 aux to,map
R1079 T1529 T1526 acl map,efforts
R1080 T1530 T1529 dobj QTL,map
R1081 T1531 T1530 prep for,QTL
R1082 T1532 T1533 amod bitter,taste
R1083 T1533 T1531 pobj taste,for
R1084 T1534 T1527 aux have,utilized
R1085 T1535 T1536 compound consumption,tests
R1086 T1536 T1527 dobj tests,utilized
R1087 T1537 T1538 dep that,confounded
R1088 T1538 T1536 relcl confounded,tests
R1089 T1539 T1538 aux may,confounded
R1090 T1540 T1538 auxpass be,confounded
R1091 T1541 T1538 agent by,confounded
R1092 T1542 T1543 det the,contributions
R1093 T1543 T1541 pobj contributions,by
R1094 T1544 T1543 prep of,contributions
R1095 T1545 T1546 amod post-ingestive,effects
R1096 T1546 T1544 pobj effects,of
R1097 T1547 T1548 punct [,29
R1098 T1548 T1538 parataxis 29,confounded
R1099 T1549 T1548 punct ],29
R1100 T1550 T1527 punct .,utilized
R1101 T1552 T1553 nsubj We,used
R1102 T1554 T1555 det a,test
R1103 T1555 T1553 dobj test,used
R1104 T1556 T1555 amod modified,test
R1105 T1557 T1558 amod brief,access
R1106 T1558 T1555 compound access,test
R1107 T1559 T1558 punct -,access
R1108 T1560 T1555 compound lick,test
R1109 T1561 T1555 punct ", ",test
R1110 T1562 T1563 dep which,minimizes
R1111 T1563 T1555 relcl minimizes,test
R1112 T1564 T1565 det the,contribution
R1113 T1565 T1563 dobj contribution,minimizes
R1114 T1566 T1565 prep of,contribution
R1115 T1567 T1568 amod such,effects
R1116 T1568 T1566 pobj effects,of
R1117 T1569 T1570 punct [,37
R1118 T1570 T1563 parataxis 37,minimizes
R1119 T1571 T1570 nummod 29,37
R1120 T1572 T1570 punct ",",37
R1121 T1573 T1570 punct ],37
R1122 T1574 T1575 aux to,determine
R1123 T1575 T1553 advcl determine,used
R1124 T1576 T1577 mark whether,display
R1125 T1577 T1575 ccomp display,determine
R1126 T1578 T1579 nmod B6,mice
R1127 T1579 T1577 nsubj mice,display
R1128 T1580 T1578 cc and,B6
R1129 T1581 T1578 conj D2,B6
R1130 T1582 T1577 dobj differences,display
R1131 T1583 T1582 prep in,differences
R1132 T1584 T1585 compound taste,sensitivity
R1133 T1585 T1583 pobj sensitivity,in
R1134 T1586 T1585 prep to,sensitivity
R1135 T1587 T1588 det the,stimuli
R1136 T1588 T1586 pobj stimuli,to
R1137 T1589 T1588 compound taste,stimuli
R1138 T1590 T1588 appos QHCl,stimuli
R1139 T1591 T1590 cc and,QHCl
R1140 T1592 T1590 conj DB,QHCl
R1141 T1593 T1553 punct .,used
R1142 T1595 T1596 prep After,selected
R1143 T1597 T1598 advmod initially,screening
R1144 T1598 T1595 pcomp screening,After
R1145 T1599 T1600 nmod B6,mice
R1146 T1600 T1598 dobj mice,screening
R1147 T1601 T1599 cc and,B6
R1148 T1602 T1599 conj D2,B6
R1149 T1603 T1604 aux to,determine
R1150 T1604 T1598 advcl determine,screening
R1151 T1605 T1606 compound stimulus,concentrations
R1152 T1606 T1604 dobj concentrations,determine
R1153 T1607 T1608 dep that,were
R1154 T1608 T1606 relcl were,concentrations
R1155 T1609 T1608 acomp aversive,were
R1156 T1610 T1609 cc but,aversive
R1157 T1611 T1610 neg not,but
R1158 T1612 T1609 conj saturating,aversive
R1159 T1613 T1614 punct [,47
R1160 T1614 T1604 parataxis 47,determine
R1161 T1615 T1614 punct ],47
R1162 T1616 T1596 punct ", ",selected
R1163 T1617 T1596 nsubj we,selected
R1164 T1618 T1619 nummod two,concentrations
R1165 T1619 T1596 dobj concentrations,selected
R1166 T1620 T1619 compound ligand,concentrations
R1167 T1621 T1619 prep for,concentrations
R1168 T1622 T1623 det each,compound
R1169 T1623 T1621 pobj compound,for
R1170 T1624 T1625 dep that,differentiated
R1171 T1625 T1619 relcl differentiated,concentrations
R1172 T1626 T1625 advmod best,differentiated
R1173 T1627 T1628 det the,strains
R1174 T1628 T1625 dobj strains,differentiated
R1175 T1629 T1628 nummod two,strains
R1176 T1630 T1596 punct .,selected
R1177 T1632 T1633 amod Subsequent,testing
R1178 T1633 T1635 nsubjpass testing,restricted
R1179 T1634 T1633 compound taste,testing
R1180 T1636 T1633 prep of,testing
R1181 T1637 T1638 nmod BXD,lines
R1182 T1638 T1636 pobj lines,of
R1183 T1639 T1638 amod RI,lines
R1184 T1640 T1635 auxpass was,restricted
R1185 T1641 T1635 prep to,restricted
R1186 T1642 T1643 det these,concentrations
R1187 T1643 T1641 pobj concentrations,to
R1188 T1644 T1643 nummod two,concentrations
R1189 T1645 T1646 punct (,mM
R1190 T1646 T1635 parataxis mM,restricted
R1191 T1647 T1646 nummod 1,mM
R1192 T1648 T1647 cc and,1
R1193 T1649 T1647 conj 3,1
R1194 T1650 T1646 prep for,mM
R1195 T1651 T1652 preconj both,QHCl
R1196 T1652 T1650 pobj QHCl,for
R1197 T1653 T1652 cc and,QHCl
R1198 T1654 T1652 conj DB,QHCl
R1199 T1655 T1646 punct ),mM
R1200 T1656 T1635 punct .,restricted
R1201 T1658 T1659 nsubj Avoidance,increased
R1202 T1660 T1658 prep by,Avoidance
R1203 T1661 T1662 amod male,mice
R1204 T1662 T1660 pobj mice,by
R1205 T1663 T1661 cc and,male
R1206 T1664 T1661 conj female,male
R1207 T1665 T1662 nmod B6,mice
R1208 T1666 T1665 cc and,B6
R1209 T1667 T1665 conj D2,B6
R1210 T1668 T1659 punct (,increased
R1211 T1669 T1670 mark as,indicated
R1212 T1670 T1659 advcl indicated,increased
R1213 T1671 T1670 agent by,indicated
R1214 T1672 T1673 det the,ratio
R1215 T1673 T1671 pobj ratio,by
R1216 T1674 T1673 amod decreased,ratio
R1217 T1675 T1673 compound lick,ratio
R1218 T1676 T1659 punct ),increased
R1219 T1677 T1659 prep in,increased
R1220 T1678 T1679 det a,manner
R1221 T1679 T1677 pobj manner,in
R1222 T1680 T1681 npadvmod concentration,dependent
R1223 T1681 T1679 amod dependent,manner
R1224 T1682 T1681 punct -,dependent
R1225 T1683 T1679 prep for,manner
R1226 T1684 T1685 det both,compounds
R1227 T1685 T1683 pobj compounds,for
R1228 T1686 T1687 punct (,Table
R1229 T1687 T1679 parataxis Table,manner
R1230 T1688 T1687 dep Figure,Table
R1231 T1689 T1688 nummod 1A,Figure
R1232 T1690 T1687 punct ;,Table
R1233 T1691 T1687 nummod 1,Table
R1234 T1692 T1687 punct ),Table
R1235 T1693 T1659 punct .,increased
R1236 T1695 T1696 expl There,was
R1237 T1697 T1698 det a,difference
R1239 T1699 T1698 amod significant,difference
R1257 T1717 T1715 punct >,24.6
R1258 T1718 T1709 punct ;,0.0001
R1259 T1719 T1709 nsubj p,0.0001
R1260 T1720 T1709 punct <,0.0001
R1261 T1721 T1709 punct ),0.0001
R1262 T1722 T1696 punct .,was
R1263 T1724 T1725 compound D2,mice
R1264 T1725 T1726 nsubj mice,displayed
R1265 T1727 T1728 amod decreased,aversion
R1266 T1728 T1726 dobj aversion,displayed
R1267 T1729 T1728 amod relative,aversion
R1268 T1730 T1729 prep to,relative
R1269 T1731 T1732 compound B6,mice
R1270 T1732 T1730 pobj mice,to
R1271 T1733 T1726 prep at,displayed
R1272 T1734 T1735 det both,concentrations
R1273 T1735 T1733 pobj concentrations,at
R1274 T1736 T1726 punct .,displayed
R1275 T1738 T1739 prep On,differ
R1276 T1740 T1741 det the,hand
R1277 T1741 T1738 pobj hand,On
R1278 T1742 T1741 amod other,hand
R1279 T1743 T1739 punct ", ",differ
R1280 T1744 T1745 det the,strains
R1281 T1745 T1739 nsubj strains,differ
R1282 T1746 T1739 aux did,differ
R1283 T1747 T1739 neg not,differ
R1284 T1748 T1739 advmod significantly,differ
R1285 T1749 T1739 prep in,differ
R1286 T1750 T1751 compound taste,sensitivity
R1287 T1751 T1749 pobj sensitivity,in
R1288 T1752 T1751 prep to,sensitivity
R1289 T1753 T1752 pobj DB,to
R1290 T1754 T1755 punct (,Figure
R1291 T1755 T1739 parataxis Figure,differ
R1292 T1756 T1755 nummod 1A,Figure
R1293 T1757 T1755 punct ),Figure
R1294 T1758 T1739 punct .,differ
R1295 T1760 T1761 expl There,were
R1296 T1762 T1763 det no,effects
R1297 T1763 T1761 attr effects,were
R1298 T1764 T1763 amod significant,effects
R1299 T1765 T1763 prep of,effects
R1300 T1766 T1765 pobj gender,of
R1301 T1767 T1761 punct .,were
R1333 T1803 T1796 punct ),Table
R1334 T1804 T1785 punct .,avoided
R1335 T1806 T1807 advmod However,vary
R1336 T1807 T1814 ccomp vary,are
R1337 T1808 T1807 punct ", ",vary
R1338 T1809 T1810 nmod QHCl,sensitivity
R1339 T1810 T1807 nsubj sensitivity,vary
R1340 T1811 T1809 cc and,QHCl
R1341 T1812 T1809 conj DB,QHCl
R1342 T1813 T1810 compound taste,sensitivity
R1343 T1815 T1807 advmod independently,vary
R1344 T1816 T1807 prep across,vary
R1345 T1817 T1818 det these,strains
R1346 T1818 T1816 pobj strains,across
R1347 T1819 T1818 amod RI,strains
R1348 T1820 T1814 punct : ,are
R1349 T1821 T1822 det some,strains
R1350 T1822 T1814 nsubj strains,are
R1351 T1823 T1824 advmod highly,sensitive
R1352 T1824 T1822 amod sensitive,strains
R1353 T1825 T1824 prep to,sensitive
R1354 T1826 T1825 pobj QHCl,to
R1355 T1827 T1828 advmod relatively,insensitive
R1356 T1828 T1814 acomp insensitive,are
R1357 T1829 T1828 prep to,insensitive
R1358 T1830 T1829 pobj DB,to
R1359 T1831 T1828 punct ", ",insensitive
R1360 T1832 T1828 cc and,insensitive
R1361 T1833 T1834 advmod vice,versa
R1362 T1834 T1828 conj versa,insensitive
R1363 T1835 T1836 punct (,1B
R1364 T1836 T1814 parataxis 1B,are
R1365 T1837 T1836 nmod Figures,1B
R1366 T1838 T1839 punct –,1D
R1367 T1839 T1836 prep 1D,1B
R1368 T1840 T1836 punct ),1B
R1369 T1841 T1814 punct .,are
R1371 T1946 T1947 compound QTL,mapping
R1372 T1949 T1950 compound Linkage,analysis
R1373 T1950 T1951 nsubjpass analysis,conducted
R1374 T1952 T1951 auxpass was,conducted
R1375 T1953 T1951 advcl using,conducted
R1376 T1954 T1955 compound Map,Manager
R1377 T1955 T1956 compound Manager,QTX
R1378 T1956 T1953 dobj QTX,using
R1379 T1957 T1958 punct (,38
R1380 T1958 T1956 parataxis 38,QTX
R1381 T1959 T1958 dep version,38
R1382 T1960 T1959 nummod 0.30,version
R1383 T1961 T1958 punct [,38
R1384 T1962 T1958 punct ],38
R1385 T1963 T1958 punct ),38
R1386 T1964 T1951 punct .,conducted
R1387 T1966 T1967 det No,QTLs
R1388 T1967 T1969 nsubjpass QTLs,identified
R1389 T1968 T1967 amod significant,QTLs
R1390 T1970 T1969 auxpass were,identified
R1391 T1971 T1969 prep for,identified
R1392 T1972 T1973 compound DB,sensitivity
R1393 T1973 T1971 pobj sensitivity,for
R1394 T1974 T1973 compound taste,sensitivity
R1395 T1975 T1969 punct ", ",identified
R1396 T1976 T1977 mark although,were
R1397 T1977 T1969 advcl were,identified
R1398 T1978 T1979 amod several,associations
R1399 T1979 T1977 nsubj associations,were
R1400 T1980 T1979 prep with,associations
R1401 T1981 T1980 pobj markers,with
R1402 T1982 T1981 prep on,markers
R1403 T1983 T1984 nmod chromosomes,2
R1404 T1984 T1982 pobj 2,on
R1405 T1985 T1984 punct ",",2
R1406 T1986 T1984 conj 8,2
R1407 T1987 T1986 cc and,8
R1408 T1988 T1986 conj 12,8
R1409 T1989 T1977 punct """",were
R1410 T1990 T1977 acomp suggestive,were
R1411 T1991 T1977 punct """",were
R1412 T1992 T1993 punct (,see
R1413 T1993 T1977 parataxis see,were
R1414 T1994 T1995 nsubj LRS,9.4
R1415 T1995 T1993 ccomp 9.4,see
R1416 T1996 T1995 punct >,9.4
R1417 T1997 T1993 punct ", ",see
R1418 T1998 T1999 npadvmod genome,wide
R1419 T1999 T2001 amod wide,p
R1420 T2000 T1999 punct -,wide
R1421 T2001 T2002 nsubj p,0.65
R1422 T2002 T1993 ccomp 0.65,see
R1423 T2003 T2002 punct =,0.65
R1424 T2004 T1993 punct ;,see
R1425 T2005 T2006 amod Additional,File
R1426 T2006 T1993 dobj File,see
R1427 T2007 T2006 nummod 1,File
R1428 T2008 T1993 punct ),see
R1429 T2009 T1969 punct .,identified
R1430 T2011 T2012 det A,QTL
R1431 T2012 T2026 nsubjpass QTL,indicated
R1432 T2013 T2012 amod significant,QTL
R1433 T2014 T2015 punct (,0.05
R1434 T2015 T2013 parataxis 0.05,significant
R1435 T2016 T2017 nsubj LRS,20.5
R1436 T2017 T2015 ccomp 20.5,0.05
R1437 T2018 T2017 punct >,20.5
R1438 T2019 T2015 punct ;,0.05
R1439 T2020 T2021 npadvmod genome,wide
R1440 T2021 T2023 amod wide,p
R1441 T2022 T2021 punct -,wide
R1442 T2023 T2015 nsubj p,0.05
R1443 T2024 T2015 punct =,0.05
R1444 T2025 T2015 punct ),0.05
R1445 T2026 T2034 ccomp indicated,were
R1446 T2027 T2012 prep for,QTL
R1447 T2028 T2027 pobj sensitivity,for
R1448 T2029 T2028 prep to,sensitivity
R1449 T2030 T2031 nummod 1,mM
R1450 T2031 T2032 compound mM,QHCl
R1451 T2032 T2029 pobj QHCl,to
R1452 T2033 T2026 auxpass was,indicated
R1453 T2035 T2026 prep on,indicated
R1454 T2036 T2035 pobj chromosome,on
R1455 T2037 T2036 nummod 6,chromosome
R1456 T2038 T2026 punct ", ",indicated
R1457 T2039 T2040 mark with,QTL
R1458 T2040 T2026 advcl QTL,indicated
R1459 T2041 T2040 det a,QTL
R1460 T2042 T2040 amod second,QTL
R1461 T2043 T2040 punct ", ",QTL
R1462 T2044 T2040 amod suggestive,QTL
R1463 T2045 T2046 punct (,0.65
R1464 T2046 T2040 parataxis 0.65,QTL
R1465 T2047 T2048 nsubj LRS,11.4
R1466 T2048 T2046 ccomp 11.4,0.65
R1467 T2049 T2048 punct >,11.4
R1468 T2050 T2046 punct ;,0.65
R1469 T2051 T2052 npadvmod genome,wide
R1470 T2052 T2054 amod wide,p
R1471 T2053 T2052 punct -,wide
R1472 T2054 T2046 nsubj p,0.65
R1473 T2055 T2046 punct =,0.65
R1474 T2056 T2046 punct ),0.65
R1475 T2057 T2040 prep on,QTL
R1476 T2058 T2057 pobj chromosome,on
R1477 T2059 T2058 nummod 8,chromosome
R1478 T2060 T2061 punct (,Figure
R1479 T2061 T2058 parataxis Figure,chromosome
R1480 T2062 T2061 nummod 2A,Figure
R1481 T2063 T2061 punct ),Figure
R1482 T2064 T2034 punct ;,were
R1483 T2065 T2034 prep at,were
R1484 T2066 T2067 nummod 3,mM
R1485 T2067 T2068 compound mM,QHCl
R1486 T2068 T2065 pobj QHCl,at
R1487 T2069 T2034 punct ", ",were
R1488 T2070 T2034 nsubj both,were
R1489 T2071 T2070 prep of,both
R1490 T2072 T2073 det these,QTL
R1491 T2073 T2071 pobj QTL,of
R1492 T2074 T2034 acomp suggestive,were
R1493 T2075 T2076 punct (,10.9
R1494 T2076 T2074 parataxis 10.9,suggestive
R1495 T2077 T2076 nsubj LRS,10.9
R1496 T2078 T2076 punct >,10.9
R1497 T2079 T2076 punct ),10.9
R1498 T2080 T2034 cc but,were
R1499 T2081 T2082 aux did,reach
R1500 T2082 T2034 conj reach,were
R1501 T2083 T2082 neg not,reach
R1502 T2084 T2085 npadvmod genome,wide
R1503 T2085 T2087 amod wide,significance
R1504 T2086 T2085 punct -,wide
R1505 T2087 T2082 dobj significance,reach
R1506 T2088 T2089 punct (,Figure
R1507 T2089 T2082 parataxis Figure,reach
R1508 T2090 T2089 nummod 2B,Figure
R1513 T2113 T2114 det a,marker
R1514 T2114 T2112 pobj marker,to
R1515 T2115 T2114 amod single,marker
R1516 T2116 T2114 punct ", ",marker
R1517 T2117 T2114 appos D6Mit13,marker
R1518 T2118 T2119 punct (,Figure
R1519 T2119 T2111 parataxis Figure,ked
R1520 T2120 T2119 dep Table,Figure
R1521 T2121 T2120 nummod 2,Table
R1522 T2122 T2119 punct ", ",Figure
R1523 T2123 T2119 nummod 3,Figure
R1524 T2124 T2119 punct ),Figure
R1525 T2125 T2111 punct .,ked
R1526 T2127 T2128 amod Adjacent,D6Mit254
R1527 T2128 T2131 nsubj D6Mit254,are
R1528 T2129 T2128 amod proximal,D6Mit254
R1529 T2130 T2128 compound markers,D6Mit254
R1530 T2132 T2128 cc and,D6Mit254
R1531 T2133 T2128 conj D6Mit194,D6Mit254
R1532 T2134 T2131 acomp unlinked,are
R1533 T2135 T2134 prep to,unlinked
R1534 T2136 T2137 det the,QTL
R1535 T2137 T2135 pobj QTL,to
R1536 T2138 T2137 compound QHCl,QTL
R1537 T2139 T2131 punct ", ",are
R1538 T2140 T2141 mark as,is
R1539 T2141 T2131 advcl is,are
R1540 T2142 T2143 amod distal,marker
R1541 T2143 T2144 compound marker,D6Mit374
R1542 T2144 T2141 nsubj D6Mit374,is
R1543 T2145 T2131 punct .,are
R1544 T2147 T2148 prep Across,is
R1545 T2149 T2150 det the,lines
R1546 T2150 T2147 pobj lines,Across
R1547 T2151 T2150 nummod 17,lines
R1548 T2152 T2150 amod RI,lines
R1549 T2153 T2150 acl tested,lines
R1550 T2154 T2148 expl there,is
R1551 T2155 T2156 advmod at,one
R1552 T2156 T2158 nummod one,event
R1553 T2157 T2156 advmod least,one
R1554 T2158 T2148 attr event,is
R1555 T2159 T2158 compound recombination,event
R1556 T2160 T2158 prep between,event
R1557 T2161 T2160 pobj D6Mit13,between
R1558 T2162 T2161 cc and,D6Mit13
R1559 T2163 T2164 preconj either,D6Mit254
R1560 T2164 T2161 conj D6Mit254,D6Mit13
R1561 T2165 T2164 punct (,D6Mit254
R1562 T2166 T2164 cc and,D6Mit254
R1563 T2167 T2164 conj D6Mit194,D6Mit254
R1564 T2168 T2167 punct ", ",D6Mit194
R1565 T2169 T2170 det the,position
R1566 T2170 T2172 dep position,is
R1567 T2171 T2170 amod physical,position
R1568 T2172 T2167 relcl is,D6Mit194
R1569 T2173 T2170 prep of,position
R1570 T2174 T2173 pobj which,of
R1571 T2175 T2172 neg not,is
R1572 T2176 T2177 advmod well,defined
R1573 T2177 T2172 acomp defined,is
R1574 T2178 T2164 punct ),D6Mit254
R1575 T2179 T2164 cc or,D6Mit254
R1576 T2180 T2164 conj D6Mit374,D6Mit254
R1577 T2181 T2148 punct .,is
R1578 T2183 T2184 det An,marker
R1579 T2184 T2187 nsubjpass marker,identified
R1580 T2185 T2184 amod additional,marker
R1581 T2186 T2184 amod proximal,marker
R1582 T2188 T2184 punct ", ",marker
R1583 T2189 T2184 appos D6Mit61,marker
R1584 T2190 T2184 punct ", ",marker
R1585 T2191 T2192 dep which,lies
R1586 T2192 T2184 relcl lies,marker
R1587 T2193 T2192 prep between,lies
R1588 T2194 T2193 pobj D6Mit194,between
R1589 T2195 T2194 cc and,D6Mit194
R1590 T2196 T2194 conj D6Mit13,D6Mit194
R1591 T2197 T2187 punct ", ",identified
R1592 T2198 T2187 auxpass was,identified
R1593 T2199 T2187 prep from,identified
R1594 T2200 T2199 pobj genotypes,from
R1595 T2201 T2200 prep of,genotypes
R1596 T2202 T2203 det the,lines
R1597 T2203 T2201 pobj lines,of
R1598 T2204 T2203 compound BXD,lines
R1599 T2205 T2200 acl reported,genotypes
R1600 T2206 T2205 agent by,reported
R1601 T2207 T2208 det the,Laboratories
R1602 T2208 T2206 pobj Laboratories,by
R1603 T2209 T2208 compound Jackson,Laboratories
R1604 T2210 T2187 punct .,identified
R1605 T2212 T2213 nmod BXD,mice
R1606 T2213 T2219 nsubj mice,display
R1607 T2214 T2212 punct /,BXD
R1608 T2215 T2212 appos Ty,BXD
R1609 T2216 T2215 punct -,Ty
R1610 T2217 T2215 nummod 34,Ty
R1611 T2218 T2213 amod RI,mice
R1612 T2220 T2221 det a,phenotype
R1613 T2221 T2219 dobj phenotype,display
R1614 T2222 T2221 amod clear,phenotype
R1615 T2223 T2221 compound D2,phenotype
R1616 T2224 T2221 prep for,phenotype
R1617 T2225 T2226 compound QHCl,taste
R1618 T2226 T2224 pobj taste,for
R1619 T2227 T2228 punct (,Figure
R1620 T2228 T2221 parataxis Figure,phenotype
R1621 T2229 T2228 nummod 1C,Figure
R1622 T2230 T2228 punct ),Figure
R1623 T2231 T2221 cc and,phenotype
R1624 T2232 T2233 compound D2,genotype
R1625 T2233 T2221 conj genotype,phenotype
R1626 T2234 T2233 prep for,genotype
R1627 T2235 T2234 pobj D6Mit13,for
R1628 T2236 T2219 punct ", ",display
R1629 T2237 T2219 cc but,display
R1630 T2238 T2219 conj have,display
R1631 T2239 T2240 det a,genotype
R1632 T2240 T2238 dobj genotype,have
R1633 T2241 T2240 compound B6,genotype
R1634 T2242 T2240 prep for,genotype
R1635 T2243 T2242 pobj D6Mit61,for
R1636 T2244 T2245 punct [,40
R1637 T2245 T2240 parataxis 40,genotype
R1638 T2246 T2245 nummod 39,40
R1639 T2247 T2245 punct ",",40
R1640 T2248 T2245 punct ],40
R1641 T2249 T2238 punct ", ",have
R1642 T2250 T2238 advcl indicating,have
R1643 T2251 T2252 mark that,is
R1644 T2252 T2250 ccomp is,indicating
R1645 T2253 T2252 nsubj D6Mit61,is
R1646 T2254 T2252 acomp unlinked,is
R1647 T2255 T2254 prep to,unlinked
R1648 T2256 T2257 det the,QTL
R1649 T2257 T2255 pobj QTL,to
R1650 T2258 T2257 compound QHCl,QTL
R1651 T2259 T2219 punct .,display
R1652 T2261 T2262 advmod Therefore,defined
R1653 T2263 T2262 punct ", ",defined
R1654 T2264 T2265 det this,interval
R1655 T2265 T2262 nsubjpass interval,defined
R1656 T2266 T2265 compound QTL,interval
R1657 T2267 T2262 aux can,defined
R1658 T2268 T2262 auxpass be,defined
R1659 T2269 T2262 advmod conservatively,defined
R1660 T2270 T2262 prep as,defined
R1661 T2271 T2272 det that,portion
R1662 T2272 T2270 pobj portion,as
R1663 T2273 T2272 prep of,portion
R1664 T2274 T2275 compound mouse,chromosome
R1665 T2275 T2273 pobj chromosome,of
R1666 T2276 T2275 nummod 6,chromosome
R1667 T2277 T2278 dep that,lies
R1668 T2278 T2272 relcl lies,portion
R1669 T2279 T2278 prep between,lies
R1670 T2280 T2279 pobj D6Mit254,between
R1671 T2281 T2280 cc and,D6Mit254
R1672 T2282 T2280 conj D6Mit374,D6Mit254
R1673 T2283 T2262 punct ", ",defined
R1674 T2284 T2262 cc but,defined
R1675 T2285 T2286 auxpass is,restricted
R1676 T2286 T2262 conj restricted,defined
R1677 T2287 T2288 advmod most,likely
R1678 T2288 T2286 advmod likely,restricted
R1679 T2289 T2286 prep to,restricted
R1680 T2290 T2291 det the,region
R1681 T2291 T2289 pobj region,to
R1682 T2292 T2291 prep between,region
R1683 T2293 T2292 pobj D6Mit61,between
R1684 T2294 T2293 cc and,D6Mit61
R1685 T2295 T2293 conj D6Mit374,D6Mit61
R1686 T2296 T2262 punct .,defined
R1687 T2298 T2299 amod Physical,mapping
R1688 T2299 T2300 nsubjpass mapping,performed
R1689 T2301 T2299 prep of,mapping
R1690 T2302 T2303 det the,marker
R1691 T2303 T2301 pobj marker,of
R1692 T2304 T2303 amod single,marker
R1693 T2305 T2303 amod linked,marker
R1694 T2306 T2303 punct ", ",marker
R1695 T2307 T2303 appos D6Mit13,marker
R1696 T2308 T2299 punct ", ",mapping
R1697 T2309 T2299 cc and,mapping
R1698 T2310 T2311 det the,markers
R1699 T2311 T2299 conj markers,mapping
R1700 T2312 T2311 nummod two,markers
R1701 T2313 T2311 amod closest,markers
R1702 T2314 T2311 amod unlinked,markers
R1703 T2315 T2311 punct ", ",markers
R1704 T2316 T2317 dep D6Mit61and,D6Mit374
R1705 T2317 T2311 nmod D6Mit374,markers
R1706 T2318 T2300 punct ", ",performed
R1707 T2319 T2300 auxpass was,performed
R1708 T2320 T2321 advmod in,silico
R1709 T2321 T2300 advmod silico,performed
R1710 T2322 T2300 prep based,performed
R1711 T2323 T2322 prep on,based
R1712 T2324 T2325 det the,build
R1713 T2325 T2323 pobj build,on
R1714 T2326 T2325 nmod May,build
R1715 T2327 T2326 punct ", ",May
R1716 T2328 T2326 npadvmod 2004,May
R1717 T2329 T2325 prep of,build
R1718 T2330 T2331 det the,genome
R1719 T2331 T2329 pobj genome,of
R1720 T2332 T2331 amod public,genome
R1721 T2333 T2331 compound B6,genome
R1722 T2334 T2300 punct .,performed
R1723 T2336 T2337 prep Based,is
R1724 T2338 T2336 prep on,Based
R1725 T2339 T2340 det these,positions
R1726 T2340 T2338 pobj positions,on
R1727 T2341 T2340 compound marker,positions
R1728 T2342 T2337 punct ", ",is
R1729 T2343 T2344 det the,size
R1730 T2344 T2337 nsubj size,is
R1731 T2345 T2344 prep of,size
R1732 T2346 T2347 det the,QTL
R1733 T2347 T2345 pobj QTL,of
R1734 T2348 T2347 nmod QHCl,QTL
R1735 T2349 T2347 nmod chromosome,QTL
R1736 T2350 T2349 nummod 6,chromosome
R1737 T2351 T2352 amod less,5.0
R1738 T2352 T2354 nummod 5.0,Mb
R1739 T2353 T2352 quantmod than,5.0
R1740 T2354 T2337 attr Mb,is
R1741 T2355 T2356 punct (,Figure
R1742 T2356 T2337 parataxis Figure,is
R1743 T2357 T2356 nummod 3,Figure
R1744 T2358 T2356 punct ),Figure
R1745 T2359 T2337 punct .,is
R1746 T2361 T2362 det This,region
R1747 T2362 T2363 nsubj region,contains
R1748 T2364 T2365 det a,number
R1749 T2365 T2363 dobj number,contains
R1750 T2366 T2365 prep of,number
R1751 T2367 T2368 amod known,genes
R1752 T2368 T2366 pobj genes,of
R1753 T2369 T2365 punct ", ",number
R1754 T2370 T2371 dep all,encode
R1755 T2371 T2365 relcl encode,number
R1756 T2372 T2370 prep but,all
R1757 T2373 T2372 pobj eleven,but
R1758 T2374 T2370 prep of,all
R1759 T2375 T2374 pobj which,of
R1760 T2376 T2371 dobj members,encode
R1761 T2377 T2376 prep of,members
R1762 T2378 T2379 nummod two,families
R1763 T2379 T2377 pobj families,of
R1764 T2380 T2379 amod large,families
R1765 T2381 T2379 compound receptor,families
R1766 T2382 T2379 punct : ,families
R1767 T2383 T2384 amod natural,cell
R1768 T2384 T2386 nmod cell,receptors
R1769 T2385 T2384 nmod killer,cell
R1770 T2386 T2379 appos receptors,families
R1771 T2387 T2388 npadvmod lectin,like
R1772 T2388 T2386 amod like,receptors
R1773 T2389 T2388 punct -,like
R1774 T2390 T2386 punct ", ",receptors
R1775 T2391 T2386 cc and,receptors
R1776 T2392 T2393 compound T2R,type
R1777 T2393 T2395 compound type,receptors
R1778 T2394 T2393 punct -,type
R1779 T2395 T2386 conj receptors,receptors
R1780 T2396 T2395 compound taste,receptors
R1781 T2397 T2363 punct .,contains
R1782 T2399 T2400 det The,genes
R1783 T2400 T2402 nsubjpass genes,found
R1784 T2401 T2400 compound Tas2r,genes
R1785 T2403 T2400 punct (,genes
R1786 T2404 T2405 dep which,encode
R1787 T2405 T2400 relcl encode,genes
R1788 T2406 T2407 det the,T2Rs
R1789 T2407 T2405 dobj T2Rs,encode
R1790 T2408 T2402 punct ),found
R1791 T2409 T2402 auxpass are,found
R1792 T2410 T2402 xcomp clustered,found
R1793 T2411 T2410 prep within,clustered
R1794 T2412 T2413 det a,interval
R1795 T2413 T2411 pobj interval,within
R1796 T2414 T2415 nummod 1.2,Mb
R1797 T2415 T2413 compound Mb,interval
R1798 T2416 T2413 prep on,interval
R1799 T2417 T2418 det either,side
R1800 T2418 T2416 pobj side,on
R1801 T2419 T2418 prep of,side
R1802 T2420 T2419 pobj D6Mit13,of
R1803 T2421 T2422 punct (,Figure
R1804 T2422 T2410 parataxis Figure,clustered
R1805 T2423 T2422 dep Figure,Figure
R1806 T2424 T2423 nummod 3,Figure
R1807 T2425 T2422 punct ", ",Figure
R1808 T2426 T2422 nummod 4,Figure
R1809 T2427 T2422 punct ),Figure
R1810 T2428 T2402 punct .,found
R1811 T2430 T2431 prep Because,hypothesized
R1812 T2432 T2430 pcomp of,Because
R1813 T2433 T2434 poss their,proximity
R1814 T2434 T2430 pobj proximity,Because
R1815 T2435 T2434 prep to,proximity
R1816 T2436 T2437 det the,marker
R1817 T2437 T2435 pobj marker,to
R1818 T2438 T2437 amod linked,marker
R1819 T2439 T2434 punct ", ",proximity
R1820 T2440 T2441 poss their,expression
R1821 T2441 T2434 conj expression,proximity
R1822 T2442 T2441 amod demonstrated,expression
R1823 T2443 T2441 prep in,expression
R1824 T2444 T2445 compound taste,cells
R1825 T2445 T2443 pobj cells,in
R1826 T2446 T2445 compound receptor,cells
R1827 T2447 T2441 punct ", ",expression
R1828 T2448 T2441 cc and,expression
R1829 T2449 T2450 poss their,role
R1830 T2450 T2441 conj role,expression
R1831 T2451 T2450 prep in,role
R1832 T2452 T2453 det the,detection
R1833 T2453 T2451 pobj detection,in
R1834 T2454 T2453 prep of,detection
R1835 T2455 T2456 advmod at,least
R1836 T2456 T2457 advmod least,compounds
R1837 T2457 T2454 pobj compounds,of
R1838 T2458 T2457 det some,compounds
R1839 T2459 T2460 amod bitter,tasting
R1840 T2460 T2457 amod tasting,compounds
R1841 T2461 T2460 punct -,tasting
R1842 T2462 T2431 punct ", ",hypothesized
R1843 T2463 T2431 nsubj we,hypothesized
R1844 T2464 T2465 mark that,were
R1845 T2465 T2431 ccomp were,hypothesized
R1846 T2466 T2465 nsubj one,were
R1847 T2467 T2466 cc or,one
R1848 T2468 T2466 conj more,one
R1849 T2469 T2466 prep of,one
R1850 T2470 T2471 det the,Tas2rs
R1851 T2471 T2469 pobj Tas2rs,of
R1852 T2472 T2471 nummod 24,Tas2rs
R1853 T2473 T2466 prep at,one
R1854 T2474 T2475 det this,locus
R1855 T2475 T2473 pobj locus,at
R1856 T2476 T2465 acomp responsible,were
R1857 T2477 T2476 prep for,responsible
R1858 T2478 T2479 det the,QTL
R1859 T2479 T2477 pobj QTL,for
R1860 T2480 T2479 amod major,QTL
R1861 T2481 T2479 compound QHCl,QTL
R1862 T2482 T2483 compound taste,sensitivity
R1863 T2483 T2479 compound sensitivity,QTL
R1864 T2484 T2431 punct .,hypothesized
R1865 T2700 T2701 compound T2R,alleles
R1866 T2703 T2704 mark If,underlie
R1867 T2704 T2711 advcl underlie,predict
R1868 T2705 T2706 nummod one,Tas2rs
R1869 T2706 T2704 nsubj Tas2rs,underlie
R1870 T2707 T2705 punct (,one
R1871 T2708 T2705 cc or,one
R1872 T2709 T2705 conj more,one
R1873 T2710 T2706 punct ),Tas2rs
R1874 T2711 T2722 ccomp predict,affects
R1875 T2712 T2713 det the,QTL
R1876 T2713 T2704 dobj QTL,underlie
R1877 T2714 T2713 nmod chromosome,QTL
R1878 T2715 T2714 nummod 6,chromosome
R1879 T2716 T2713 compound QHCl,QTL
R1880 T2717 T2718 compound taste,sensitivity
R1881 T2718 T2713 compound sensitivity,QTL
R1882 T2719 T2711 punct ", ",predict
R1883 T2720 T2711 nsubj we,predict
R1884 T2721 T2711 aux would,predict
R1885 T2723 T2724 mark that,exhibit
R1886 T2724 T2711 ccomp exhibit,predict
R1887 T2725 T2726 nummod one,genes
R1888 T2726 T2724 nsubj genes,exhibit
R1889 T2727 T2725 punct (,one
R1890 T2728 T2725 cc or,one
R1891 T2729 T2725 conj more,one
R1892 T2730 T2726 punct ),genes
R1893 T2731 T2726 compound Tas2r,genes
R1894 T2732 T2724 aux would,exhibit
R1895 T2733 T2724 dobj one,exhibit
R1896 T2734 T2733 prep of,one
R1897 T2735 T2736 nummod three,characteristics
R1898 T2736 T2734 pobj characteristics,of
R1899 T2737 T2736 amod likely,characteristics
R1900 T2738 T2722 punct : ,affects
R1901 T2739 T2740 punct (,1
R1902 T2740 T2741 meta 1,is
R1903 T2741 T2722 ccomp is,affects
R1904 T2742 T2740 punct ),1
R1905 T2743 T2744 compound A,allele
R1906 T2744 T2741 nsubj allele,is
R1907 T2745 T2744 compound Tas2r,allele
R1908 T2746 T2747 det a,pseudogene
R1909 T2747 T2741 attr pseudogene,is
R1910 T2748 T2741 punct ", ",is
R1911 T2749 T2741 cc or,is
R1912 T2750 T2751 auxpass is,deleted
R1913 T2751 T2741 conj deleted,is
R1914 T2752 T2751 punct ", ",deleted
R1915 T2753 T2751 prep in,deleted
R1916 T2754 T2755 nmod D2,mice
R1917 T2755 T2753 pobj mice,in
R1918 T2756 T2757 punct (,insensitive
R1919 T2757 T2754 parataxis insensitive,D2
R1920 T2758 T2757 npadvmod QHCL,insensitive
R1921 T2759 T2757 punct -,insensitive
R1922 T2760 T2757 punct ),insensitive
R1923 T2761 T2754 punct ", ",D2
R1924 T2762 T2754 cc but,D2
R1925 T2763 T2762 neg not,but
R1926 T2764 T2754 conj B6,D2
R1927 T2765 T2766 punct (,sensitive
R1928 T2766 T2764 parataxis sensitive,B6
R1929 T2767 T2766 npadvmod QHCl,sensitive
R1930 T2768 T2766 punct -,sensitive
R1931 T2769 T2766 punct ),sensitive
R1932 T2770 T2755 punct ", ",mice
R1933 T2771 T2722 punct ;,affects
R1934 T2772 T2773 punct (,2
R1935 T2773 T2774 meta 2,impact
R1936 T2774 T2722 ccomp impact,affects
R1937 T2775 T2773 punct ),2
R1938 T2776 T2777 compound Missense,mutations
R1939 T2777 T2774 nsubj mutations,impact
R1940 T2778 T2777 prep in,mutations
R1941 T2779 T2780 det the,exon
R1942 T2780 T2778 pobj exon,in
R1943 T2781 T2780 amod single,exon
R1944 T2782 T2780 amod coding,exon
R1945 T2783 T2780 prep of,exon
R1946 T2784 T2785 det a,allele
R1947 T2785 T2783 pobj allele,of
R1948 T2786 T2785 compound D2,allele
R1949 T2787 T2785 compound Tas2r,allele
R1950 T2788 T2789 compound protein,functions
R1951 T2789 T2774 dobj functions,impact
R1952 T2790 T2791 amod such,as
R1953 T2791 T2789 prep as,functions
R1954 T2792 T2793 compound ligand,binding
R1955 T2793 T2791 pobj binding,as
R1956 T2794 T2793 cc or,binding
R1957 T2795 T2796 compound receptor,coupling
R1958 T2796 T2793 conj coupling,binding
R1959 T2797 T2796 prep to,coupling
R1960 T2798 T2799 amod downstream,cascades
R1961 T2799 T2797 pobj cascades,to
R1962 T2800 T2799 compound signaling,cascades
R1963 T2801 T2722 punct ;,affects
R1964 T2802 T2803 punct (,3
R1965 T2803 T2722 meta 3,affects
R1966 T2804 T2803 punct ),3
R1967 T2805 T2722 nsubj Mutations,affects
R1968 T2806 T2805 prep in,Mutations
R1969 T2807 T2808 amod noncoding,regions
R1970 T2808 T2806 pobj regions,in
R1971 T2809 T2807 cc or,noncoding
R1972 T2810 T2807 conj regulatory,noncoding
R1973 T2811 T2808 prep of,regions
R1974 T2812 T2813 det a,allele
R1975 T2813 T2811 pobj allele,of
R1976 T2814 T2813 compound D2,allele
R1977 T2815 T2813 compound Tas2r,allele
R1978 T2816 T2722 dobj expression,affects
R1979 T2817 T2816 prep of,expression
R1980 T2818 T2819 det the,product
R1981 T2819 T2817 pobj product,of
R1982 T2820 T2819 compound protein,product
R1983 T2821 T2722 punct .,affects
R1984 T2823 T2824 mark Though,considered
R1985 T2824 T2826 advcl considered,focused
R1986 T2825 T2824 nsubj we,considered
R1987 T2827 T2828 det all,three
R1988 T2828 T2829 nsubj three,be
R1989 T2829 T2824 ccomp be,considered
R1990 T2830 T2828 prep of,three
R1991 T2831 T2830 pobj these,of
R1992 T2832 T2829 aux to,be
R1993 T2833 T2834 amod valid,possibilities
R1994 T2834 T2829 attr possibilities,be
R1995 T2835 T2826 punct ", ",focused
R1996 T2836 T2826 nsubj we,focused
R1997 T2837 T2826 advmod initially,focused
R1998 T2838 T2826 prep on,focused
R1999 T2839 T2840 det the,likelihood
R2000 T2840 T2838 pobj likelihood,on
R2001 T2841 T2842 mark that,correlate
R2002 T2842 T2840 acl correlate,likelihood
R2003 T2843 T2842 nsubj deletion,correlate
R2004 T2844 T2843 cc or,deletion
R2005 T2845 T2843 conj mutation,deletion
R2006 T2846 T2843 prep within,deletion
R2007 T2847 T2848 det the,sequence
R2008 T2848 T2846 pobj sequence,within
R2009 T2849 T2848 amod coding,sequence
R2010 T2850 T2848 prep of,sequence
R2011 T2851 T2852 det a,Tas2r
R2012 T2852 T2850 pobj Tas2r,of
R2013 T2853 T2852 amod single,Tas2r
R2014 T2854 T2852 compound D2,Tas2r
R2015 T2855 T2842 aux would,correlate
R2016 T2856 T2842 prep with,correlate
R2017 T2857 T2858 det the,phenotype
R2018 T2858 T2856 pobj phenotype,with
R2019 T2859 T2860 compound QHCl,taste
R2020 T2860 T2861 compound taste,insensitivity
R2021 T2861 T2858 compound insensitivity,phenotype
R2022 T2862 T2826 punct .,focused
R2023 T2864 T2865 compound Twenty,four
R2024 T2865 T2867 nummod four,Tas2rs
R2025 T2866 T2865 punct -,four
R2026 T2867 T2869 nsubjpass Tas2rs,identified
R2027 T2868 T2867 amod intact,Tas2rs
R2028 T2870 T2867 punct ", ",Tas2rs
R2029 T2871 T2867 prep along,Tas2rs
R2030 T2872 T2871 prep with,along
R2031 T2873 T2874 nummod three,pseudogenes
R2032 T2874 T2872 pobj pseudogenes,with
R2033 T2875 T2874 amod apparent,pseudogenes
R2034 T2876 T2874 compound Tas2r,pseudogenes
R2035 T2877 T2869 punct ", ",identified
R2036 T2878 T2869 aux have,identified
R2037 T2879 T2869 auxpass been,identified
R2038 T2880 T2869 prep in,identified
R2039 T2881 T2882 det the,cluster
R2040 T2882 T2880 pobj cluster,in
R2041 T2883 T2882 amod distal,cluster
R2042 T2884 T2882 nmod chromosome,cluster
R2043 T2885 T2884 nummod 6,chromosome
R2044 T2886 T2882 prep of,cluster
R2045 T2887 T2888 compound B6,mice
R2046 T2888 T2886 pobj mice,of
R2047 T2889 T2890 punct [,19
R2048 T2890 T2869 parataxis 19,identified
R2049 T2891 T2890 punct ],19
R2050 T2892 T2893 punct (,Figure
R2051 T2893 T2869 parataxis Figure,identified
R2052 T2894 T2893 nummod 4,Figure
R2053 T2895 T2893 punct ),Figure
R2054 T2896 T2869 punct .,identified
R2055 T2898 T2899 nsubj We,designed
R2056 T2900 T2899 dobj oligonucleotides,designed
R2057 T2901 T2900 prep to,oligonucleotides
R2058 T2902 T2903 amod non-coding,regions
R2059 T2903 T2901 pobj regions,to
R2060 T2904 T2903 acl flanking,regions
R2061 T2905 T2906 det the,sequence
R2062 T2906 T2904 dobj sequence,flanking
R2063 T2907 T2906 compound coding,sequence
R2064 T2908 T2906 prep of,sequence
R2065 T2909 T2910 det each,Tas2r
R2066 T2910 T2908 pobj Tas2r,of
R2067 T2911 T2910 amod intact,Tas2r
R2068 T2912 T2913 punct [,see
R2069 T2913 T2899 parataxis see,designed
R2070 T2914 T2915 amod Additional,file
R2071 T2915 T2913 dobj file,see
R2072 T2916 T2915 nummod 2,file
R2073 T2917 T2913 punct ],see
R2074 T2918 T2899 punct .,designed
R2075 T2920 T2921 advcl Using,amplified
R2076 T2922 T2923 det these,oligos
R2077 T2923 T2920 dobj oligos,Using
R2078 T2924 T2921 punct ", ",amplified
R2079 T2925 T2921 nsubj we,amplified
R2080 T2926 T2927 det each,sequence
R2081 T2927 T2921 dobj sequence,amplified
R2082 T2928 T2927 compound Tas2r,sequence
R2083 T2929 T2927 compound coding,sequence
R2084 T2930 T2921 prep from,amplified
R2085 T2931 T2932 nmod D2,DNA
R2086 T2932 T2930 pobj DNA,from
R2087 T2933 T2932 amod genomic,DNA
R2088 T2934 T2921 punct .,amplified
R2089 T2936 T2937 compound PCR,products
R2090 T2937 T2938 nsubjpass products,subcloned
R2091 T2939 T2938 auxpass were,subcloned
R2092 T2940 T2938 prep into,subcloned
R2093 T2941 T2942 compound cloning,vectors
R2094 T2942 T2940 pobj vectors,into
R2095 T2943 T2938 cc and,subcloned
R2096 T2944 T2938 conj sequenced,subcloned
R2097 T2945 T2938 punct .,subcloned
R2098 T2947 T2948 nsubj Comparisons,revealed
R2099 T2949 T2947 prep of,Comparisons
R2100 T2950 T2951 det the,sequences
R2101 T2951 T2949 pobj sequences,of
R2102 T2952 T2951 prep of,sequences
R2103 T2953 T2954 nmod B6,orthologues
R2104 T2954 T2952 pobj orthologues,of
R2105 T2955 T2953 cc and,B6
R2106 T2956 T2953 conj D2,B6
R2107 T2957 T2958 mark that,were
R2108 T2958 T2948 ccomp were,revealed
R2109 T2959 T2960 advmod only,two
R2110 T2960 T2958 nsubj two,were
R2111 T2961 T2960 prep of,two
R2112 T2962 T2963 det the,alleles
R2113 T2963 T2961 pobj alleles,of
R2114 T2964 T2965 compound twenty,four
R2115 T2965 T2963 nummod four,alleles
R2116 T2966 T2965 punct -,four
R2117 T2967 T2963 compound Tas2r,alleles
R2118 T2968 T2963 acl examined,alleles
R2119 T2969 T2960 punct ", ",two
R2120 T2970 T2960 appos Tas2r106,two
R2121 T2971 T2970 cc and,Tas2r106
R2122 T2972 T2970 conj Tas2r124,Tas2r106
R2123 T2973 T2958 punct ", ",were
R2124 T2974 T2958 acomp identical,were
R2125 T2975 T2958 prep across,were
R2126 T2976 T2975 pobj strains,across
R2127 T2977 T2958 prep at,were
R2128 T2978 T2979 det the,level
R2129 T2979 T2977 pobj level,at
R2130 T2980 T2981 compound amino,acid
R2131 T2981 T2979 compound acid,level
R2132 T2982 T2983 punct (,shown
R2133 T2983 T2958 parataxis shown,were
R2134 T2984 T2983 nsubj data,shown
R2135 T2985 T2983 neg not,shown
R2136 T2986 T2983 punct ),shown
R2137 T2987 T2948 punct .,revealed
R2138 T2989 T2990 det A,third
R2139 T2990 T2991 nsubjpass third,amplified
R2140 T2992 T2990 punct ", ",third
R2141 T2993 T2990 appos Tas2r120,third
R2142 T2994 T2991 punct ", ",amplified
R2143 T2995 T2991 aux could,amplified
R2144 T2996 T2991 neg not,amplified
R2145 T2997 T2991 auxpass be,amplified
R2146 T2998 T2991 prep from,amplified
R2147 T2999 T3000 nmod D2,DNA
R2148 T3000 T2998 pobj DNA,from
R2149 T3001 T3000 amod genomic,DNA
R2150 T3002 T3003 punct (,Figure
R2151 T3003 T3000 parataxis Figure,DNA
R2152 T3004 T3003 nummod 5,Figure
R2153 T3005 T3003 punct ),Figure
R2154 T3006 T2991 advcl using,amplified
R2155 T3007 T3006 dobj either,using
R2156 T3008 T3007 prep of,either
R2157 T3009 T3010 nummod two,pairs
R2158 T3010 T3008 pobj pairs,of
R2159 T3011 T3010 prep of,pairs
R2160 T3012 T3011 pobj oligonucleotides,of
R2161 T3013 T3014 punct (,file
R2162 T3014 T3006 parataxis file,using
R2163 T3015 T3014 amod Additional,file
R2164 T3016 T3014 nummod 2,file
R2165 T3017 T3014 punct ),file
R2166 T3018 T2991 punct ", ",amplified
R2167 T3019 T2991 advcl suggesting,amplified
R2168 T3020 T3021 mark that,deleted
R2169 T3021 T3019 ccomp deleted,suggesting
R2170 T3022 T3023 det this,Tas2r
R2171 T3023 T3021 nsubjpass Tas2r,deleted
R2172 T3024 T3021 auxpass is,deleted
R2173 T3025 T3021 prep in,deleted
R2174 T3026 T3027 compound D2,mice
R2175 T3027 T3025 pobj mice,in
R2176 T3028 T2991 punct .,amplified
R2177 T3030 T3031 nummod Two,alleles
R2178 T3031 T3033 nsubj alleles,contained
R2179 T3032 T3031 compound D2,alleles
R2180 T3033 T3039 ccomp contained,be
R2181 T3034 T3031 punct ", ",alleles
R2182 T3035 T3031 appos Tas2r103,alleles
R2183 T3036 T3035 cc and,Tas2r103
R2184 T3037 T3035 conj Tas2r117,Tas2r103
R2185 T3038 T3033 punct ", ",contained
R2186 T3040 T3041 amod numerous,mutations
R2187 T3041 T3033 dobj mutations,contained
R2188 T3042 T3041 compound missense,mutations
R2189 T3043 T3041 cc and,mutations
R2190 T3044 T3045 amod small,deletions
R2191 T3045 T3041 conj deletions,mutations
R2192 T3046 T3047 dep that,create
R2193 T3047 T3045 relcl create,deletions
R2194 T3048 T3049 compound frame,shifts
R2195 T3049 T3047 dobj shifts,create
R2196 T3050 T3049 cc and,shifts
R2197 T3051 T3052 amod premature,termination
R2198 T3052 T3049 conj termination,shifts
R2199 T3053 T3039 punct ;,be
R2200 T3054 T3055 det these,genes
R2201 T3055 T3039 nsubj genes,be
R2202 T3056 T3055 nummod two,genes
R2203 T3057 T3039 aux may,be
R2204 T3058 T3039 attr pseudogenes,be
R2205 T3059 T3039 prep in,be
R2206 T3060 T3061 det this,strain
R2207 T3061 T3059 pobj strain,in
R2208 T3062 T3039 punct .,be
R2209 T3064 T3065 det The,Tas2rs
R2210 T3065 T3068 nsubj Tas2rs,contained
R2211 T3066 T3065 amod remaining,Tas2rs
R2212 T3067 T3065 nummod 19,Tas2rs
R2213 T3069 T3070 quantmod between,one
R2214 T3070 T3071 nummod one,mutations
R2215 T3071 T3068 dobj mutations,contained
R2216 T3072 T3070 cc and,one
R2217 T3073 T3070 conj 16,one
R2218 T3074 T3071 compound missense,mutations
R2219 T3075 T3068 punct .,contained
R2220 T3077 T3078 det All,Tas2rs
R2221 T3078 T3080 nsubj Tas2rs,have
R2222 T3079 T3078 nummod 24,Tas2rs
R2223 T3081 T3078 acl examined,Tas2rs
R2224 T3082 T3083 amod different,alleles
R2225 T3083 T3080 dobj alleles,have
R2226 T3084 T3080 prep in,have
R2227 T3085 T3086 nmod B6,mice
R2228 T3086 T3084 pobj mice,in
R2229 T3087 T3085 cc and,B6
R2230 T3088 T3085 conj D2,B6
R2231 T3089 T3080 punct ", ",have
R2232 T3090 T3080 cc and,have
R2233 T3091 T3092 nummod 307,polymorphisms
R2234 T3092 T3095 nsubj polymorphisms,are
R2235 T3093 T3092 amod single,polymorphisms
R2236 T3094 T3092 compound nucleotide,polymorphisms
R2237 T3095 T3080 conj are,have
R2238 T3096 T3095 acomp present,are
R2239 T3097 T3095 prep within,are
R2240 T3098 T3099 compound coding,exons
R2241 T3099 T3097 pobj exons,within
R2242 T3100 T3101 punct (,shown
R2243 T3101 T3095 parataxis shown,are
R2244 T3102 T3101 nsubj data,shown
R2245 T3103 T3101 neg not,shown
R2246 T3104 T3101 punct ),shown
R2247 T3105 T3095 punct .,are
R2248 T3107 T3108 mark Although,found
R2250 T3109 T3110 amod polymorphic,residues
R2251 T3110 T3108 nsubjpass residues,found
R2252 T3111 T3110 prep between,residues
R2253 T3112 T3113 nmod B6,Tas2rs
R2255 T3114 T3112 cc and,B6
R2256 T3115 T3112 conj D2,B6
R2326 T3195 T3193 nsubj we,proceeded
R2327 T3196 T3197 aux to,screen
R2328 T3197 T3193 xcomp screen,proceeded
R2329 T3198 T3199 amod genomic,DNA
R2330 T3199 T3197 dobj DNA,screen
R2331 T3200 T3199 prep from,DNA
R2332 T3201 T3202 nummod 29,lines
R2333 T3202 T3200 pobj lines,from
R2334 T3203 T3202 amod available,lines
R2335 T3204 T3202 nmod BXD,lines
R2336 T3205 T3202 amod RI,lines
R2337 T3206 T3202 punct ", ",lines
R2338 T3207 T3202 prep including,lines
R2339 T3208 T3209 det the,17
R2340 T3209 T3207 pobj 17,including
R2341 T3210 T3211 dep that,used
R2342 T3211 T3209 relcl used,17
R2343 T3212 T3211 nsubj we,used
R2344 T3213 T3211 aux had,used
R2345 T3214 T3211 prep in,used
R2346 T3215 T3216 compound taste,testing
R2347 T3216 T3214 pobj testing,in
R2348 T3217 T3197 punct ", ",screen
R2349 T3218 T3197 prep for,screen
R2350 T3219 T3220 det the,Tas2r
R2351 T3220 T3218 pobj Tas2r,for
R2352 T3221 T3220 nmod alleles,Tas2r
R2353 T3222 T3223 nsubj they,contained
R2354 T3223 T3220 advcl contained,Tas2r
R2355 T3224 T3193 punct .,proceeded
R2356 T3226 T3227 prep In,were
R2357 T3228 T3229 amod most,cases
R2358 T3229 T3226 pobj cases,In
R2359 T3230 T3227 punct ", ",were
R2360 T3231 T3227 nsubj we,were
R2361 T3232 T3227 acomp able,were
R2362 T3233 T3234 aux to,identify
R2363 T3234 T3232 xcomp identify,able
R2364 T3235 T3236 amod diagnostic,digests
R2365 T3236 T3234 dobj digests,identify
R2366 T3237 T3236 compound restriction,digests
R2367 T3238 T3236 compound endonuclease,digests
R2368 T3239 T3240 dep that,allow
R2369 T3240 T3236 relcl allow,digests
R2370 T3241 T3240 aux would,allow
R2371 T3242 T3243 nsubj us,identify
R2372 T3243 T3240 ccomp identify,allow
R2373 T3244 T3243 aux to,identify
R2374 T3245 T3243 advmod quickly,identify
R2375 T3246 T3247 mark whether,amplified
R2376 T3247 T3243 ccomp amplified,identify
R2377 T3248 T3249 det a,product
R2378 T3249 T3247 nsubjpass product,amplified
R2379 T3250 T3249 amod particular,product
R2380 T3251 T3249 compound Tas2r,product
R2381 T3252 T3249 compound PCR,product
R2382 T3253 T3247 auxpass was,amplified
R2383 T3254 T3247 prep from,amplified
R2384 T3255 T3256 det a,allele
R2385 T3256 T3254 pobj allele,from
R2386 T3257 T3256 nmod B6,allele
R2387 T3258 T3257 cc or,B6
R2388 T3259 T3257 conj D2,B6
R2389 T3260 T3227 punct .,were
R2390 T3262 T3263 nsubj We,analyze
R2391 T3264 T3263 aux did,analyze
R2392 T3265 T3263 neg not,analyze
R2393 T3266 T3267 nummod three,genes
R2394 T3267 T3263 dobj genes,analyze
R2395 T3268 T3267 punct (,genes
R2396 T3269 T3267 appos Tas2r104,genes
R2397 T3270 T3269 punct ", ",Tas2r104
R2398 T3271 T3269 conj Tas2r114,Tas2r104
R2399 T3272 T3271 cc and,Tas2r114
R2400 T3273 T3271 conj Tas2r110,Tas2r114
R2401 T3274 T3267 punct ),genes
R2402 T3275 T3276 advmod where,identified
R2403 T3276 T3267 relcl identified,genes
R2404 T3277 T3278 det no,endonuclease
R2405 T3278 T3276 nsubjpass endonuclease,identified
R2406 T3279 T3278 amod diagnostic,endonuclease
R2407 T3280 T3278 compound restriction,endonuclease
R2408 T3281 T3276 aux could,identified
R2409 T3282 T3276 auxpass be,identified
R2410 T3283 T3263 punct .,analyze
R2411 T3285 T3286 prep For,was
R2412 T3287 T3285 pobj Tas2r120,For
R2413 T3288 T3287 punct ", ",Tas2r120
R2414 T3289 T3290 dep which,deleted
R2415 T3290 T3287 relcl deleted,Tas2r120
R2416 T3291 T3290 auxpass is,deleted
R2417 T3292 T3290 advmod likely,deleted
R2418 T3293 T3290 prep in,deleted
R2419 T3294 T3295 compound D2,mice
R2420 T3295 T3293 pobj mice,in
R2421 T3296 T3286 punct ", ",was
R2422 T3297 T3298 det the,absence
R2423 T3298 T3286 nsubj absence,was
R2424 T3299 T3298 prep of,absence
R2425 T3300 T3301 det a,product
R2426 T3301 T3299 pobj product,of
R2427 T3302 T3301 compound PCR,product
R2428 T3303 T3286 acomp diagnostic,was
R2429 T3304 T3303 prep of,diagnostic
R2430 T3305 T3306 det the,genotype
R2431 T3306 T3304 pobj genotype,of
R2432 T3307 T3306 compound D2,genotype
R2433 T3308 T3306 prep for,genotype
R2434 T3309 T3310 det this,gene
R2435 T3310 T3308 pobj gene,for
R2436 T3311 T3286 punct .,was
R2437 T3313 T3314 advmod Surprisingly,discovered
R2438 T3315 T3314 punct ", ",discovered
R2439 T3316 T3314 nsubj we,discovered
R2440 T3317 T3318 mark that,been
R2441 T3318 T3314 ccomp been,discovered
R2442 T3319 T3318 expl there,been
R2443 T3320 T3318 aux have,been
R2444 T3321 T3322 det no,events
R2445 T3322 T3318 attr events,been
R2446 T3323 T3322 amod apparent,events
R2447 T3324 T3322 compound recombination,events
R2448 T3325 T3322 prep within,events
R2449 T3326 T3327 det the,cluster
R2450 T3327 T3325 pobj cluster,within
R2451 T3328 T3327 amod distal,cluster
R2452 T3329 T3327 nmod chromosome,cluster
R2453 T3330 T3329 nummod 6,chromosome
R2454 T3331 T3318 prep during,been
R2455 T3332 T3333 det the,generation
R2456 T3333 T3331 pobj generation,during
R2457 T3334 T3333 prep of,generation
R2458 T3335 T3336 det the,lines
R2459 T3336 T3334 pobj lines,of
R2460 T3337 T3336 nmod BXD,lines
R2461 T3338 T3336 amod RI,lines
R2462 T3339 T3314 punct .,discovered
R2463 T3341 T3342 prep For,originated
R2464 T3343 T3344 det all,lines
R2465 T3344 T3341 pobj lines,For
R2466 T3345 T3344 amod RI,lines
R2467 T3346 T3344 acl tested,lines
R2468 T3347 T3342 punct ", ",originated
R2469 T3348 T3349 det every,Tas2r
R2470 T3349 T3342 nsubj Tas2r,originated
R2471 T3350 T3349 prep within,Tas2r
R2472 T3351 T3352 det an,line
R2473 T3352 T3350 pobj line,within
R2474 T3353 T3352 amod individual,line
R2475 T3354 T3352 amod RI,line
R2476 T3355 T3342 prep from,originated
R2477 T3356 T3357 det the,strain
R2478 T3357 T3355 pobj strain,from
R2479 T3358 T3357 amod same,strain
R2480 T3359 T3357 amod parental,strain
R2481 T3360 T3361 punct (,6
R2482 T3361 T3342 parataxis 6,originated
R2483 T3362 T3361 nmod Figures,6
R2484 T3363 T3361 nummod 5,6
R2485 T3364 T3361 punct ", ",6
R2486 T3365 T3361 punct ),6
R2487 T3366 T3342 punct .,originated
R2488 T3368 T3369 advmod Furthermore,correlated
R2489 T3370 T3369 punct ", ",correlated
R2490 T3371 T3372 det the,genotype
R2491 T3372 T3369 nsubj genotype,correlated
R2492 T3373 T3372 prep of,genotype
R2493 T3374 T3375 det each,gene
R2494 T3375 T3373 pobj gene,of
R2495 T3376 T3375 compound Tas2r,gene
R2496 T3377 T3369 advmod always,correlated
R2497 T3378 T3369 prep with,correlated
R2498 T3379 T3380 det the,phenotype
R2499 T3380 T3378 pobj phenotype,with
R2500 T3381 T3380 compound QHCl,phenotype
R2501 T3382 T3380 compound taste,phenotype
R2502 T3383 T3384 punct (,7
R2503 T3384 T3369 parataxis 7,correlated
R2504 T3385 T3384 nmod Figures,7
R2505 T3386 T3384 nummod 6,7
R2506 T3387 T3384 punct ", ",7
R2507 T3388 T3384 punct ),7
R2508 T3389 T3369 punct ", ",correlated
R2509 T3390 T3369 advcl suggesting,correlated
R2510 T3391 T3392 mark that,is
R2511 T3392 T3390 ccomp is,suggesting
R2512 T3393 T3394 det the,cluster
R2513 T3394 T3392 nsubj cluster,is
R2514 T3395 T3394 amod entire,cluster
R2515 T3396 T3394 compound Tas2r,cluster
R2516 T3397 T3398 det a,haplotype
R2517 T3398 T3392 attr haplotype,is
R2518 T3399 T3398 amod single,haplotype
R2519 T3400 T3401 dep that,varies
R2520 T3401 T3398 relcl varies,haplotype
R2521 T3402 T3401 prep with,varies
R2522 T3403 T3404 compound QHCl,taster
R2523 T3404 T3405 compound taster,status
R2524 T3405 T3402 pobj status,with
R2525 T3406 T3369 punct .,correlated
R2529 T3740 T3741 det The,system
R2530 T3741 T3743 nsubjpass system,thought
R2531 T3742 T3741 amod gustatory,system
R2532 T3744 T3741 prep of,system
R2533 T3745 T3744 pobj mammals,of
R2534 T3746 T3743 auxpass is,thought
R2535 T3747 T3748 aux to,detect
R2536 T3748 T3743 xcomp detect,thought
R2537 T3749 T3748 dobj thousands,detect
R2538 T3750 T3749 prep of,thousands
R2539 T3751 T3752 advmod chemically,diverse
R2540 T3752 T3754 amod diverse,substances
R2541 T3753 T3752 punct -,diverse
R2542 T3754 T3750 pobj substances,of
R2543 T3755 T3756 amod bitter,tasting
R2544 T3756 T3754 amod tasting,substances
R2545 T3757 T3756 punct -,tasting
R2546 T3758 T3759 punct [,41
R2547 T3759 T3748 parataxis 41,detect
R2548 T3760 T3759 punct ],41
R2549 T3761 T3743 punct .,thought
R2550 T3763 T3764 mark Although,implicated
R2551 T3764 T3773 advcl implicated,understood
R2552 T3765 T3766 amod specific,receptors
R2553 T3766 T3764 nsubjpass receptors,implicated
R2554 T3767 T3766 punct ", ",receptors
R2555 T3768 T3766 conj enzymes,receptors
R2556 T3769 T3768 cc and,enzymes
R2557 T3770 T3768 conj channels,enzymes
R2558 T3771 T3764 aux have,implicated
R2559 T3772 T3764 auxpass been,implicated
R2560 T3774 T3764 prep in,implicated
R2561 T3775 T3776 det the,transduction
R2562 T3776 T3774 pobj transduction,in
R2563 T3777 T3776 prep of,transduction
R2564 T3778 T3779 amod bitter,stimuli
R2565 T3779 T3777 pobj stimuli,of
R2566 T3780 T3773 punct ", ",understood
R2567 T3781 T3782 advmod how,lead
R2568 T3782 T3773 csubjpass lead,understood
R2569 T3783 T3782 nsubj interactions,lead
R2570 T3784 T3783 prep of,interactions
R2571 T3785 T3786 amod bitter,stimuli
R2572 T3786 T3784 pobj stimuli,of
R2573 T3787 T3783 prep with,interactions
R2574 T3788 T3789 compound taste,cells
R2575 T3789 T3787 pobj cells,with
R2576 T3790 T3789 compound receptor,cells
R2577 T3791 T3782 prep to,lead
R2578 T3792 T3793 amod cellular,activation
R2579 T3793 T3791 pobj activation,to
R2580 T3794 T3793 cc and,activation
R2581 T3795 T3793 conj signaling,activation
R2582 T3796 T3795 prep to,signaling
R2583 T3797 T3798 det the,system
R2584 T3798 T3796 pobj system,to
R2585 T3799 T3798 amod central,system
R2586 T3800 T3798 amod nervous,system
R2587 T3801 T3773 auxpass is,understood
R2588 T3802 T3773 advmod still,understood
R2589 T3803 T3773 advmod poorly,understood
R2590 T3804 T3773 punct .,understood
R2591 T3806 T3807 nsubj We,found
R2592 T3808 T3807 aux have,found
R2593 T3809 T3810 mark that,accounts
R2594 T3810 T3807 ccomp accounts,found
R2595 T3811 T3812 det a,QTL
R2596 T3812 T3810 nsubj QTL,accounts
R2597 T3813 T3812 amod single,QTL
R2598 T3814 T3812 prep on,QTL
R2599 T3815 T3816 amod distal,chromosome
R2600 T3816 T3814 pobj chromosome,on
R2601 T3817 T3816 nummod 6,chromosome
R2602 T3818 T3810 prep for,accounts
R2603 T3819 T3818 pobj most,for
R2604 T3820 T3819 prep of,most
R2605 T3821 T3822 det the,variation
R2606 T3822 T3820 pobj variation,of
R2607 T3823 T3822 prep in,variation
R2608 T3824 T3825 compound QHCL,taste
R2609 T3825 T3826 compound taste,sensitivity
R2610 T3826 T3823 pobj sensitivity,in
R2611 T3827 T3822 prep between,variation
R2612 T3828 T3829 nmod B6,mice
R2613 T3829 T3827 pobj mice,between
R2614 T3830 T3828 cc and,B6
R2615 T3831 T3828 conj D2,B6
R2616 T3832 T3807 punct .,found
R2617 T3834 T3835 det This,QTL
R2618 T3835 T3836 nsubj QTL,maps
R2619 T3837 T3836 prep to,maps
R2620 T3838 T3839 det the,position
R2621 T3839 T3837 pobj position,to
R2622 T3840 T3839 amod same,position
R2623 T3841 T3839 amod chromosomal,position
R2624 T3842 T3839 prep as,position
R2625 T3843 T3844 det a,QTL
R2626 T3844 T3842 pobj QTL,as
R2627 T3845 T3846 advmod previously,identified
R2628 T3846 T3844 amod identified,QTL
R2629 T3847 T3844 prep for,QTL
R2630 T3848 T3849 compound quinine,intake
R2631 T3849 T3847 pobj intake,for
R2632 T3850 T3844 punct ", ",QTL
R2633 T3851 T3844 appos Qui,QTL
R2634 T3852 T3853 punct [,28
R2635 T3853 T3836 parataxis 28,maps
R2636 T3854 T3853 nummod 16,28
R2637 T3855 T3853 punct ",",28
R2638 T3856 T3853 punct ],28
R2639 T3857 T3836 punct ", ",maps
R2640 T3858 T3836 advcl indicating,maps
R2641 T3859 T3860 mark that,is
R2642 T3860 T3858 ccomp is,indicating
R2643 T3861 T3860 nsubj taste,is
R2644 T3862 T3863 det the,factor
R2645 T3863 T3860 attr factor,is
R2646 T3864 T3863 amod major,factor
R2647 T3865 T3863 prep in,factor
R2648 T3866 T3865 pcomp regulating,in
R2649 T3867 T3868 compound quinine,aversion
R2650 T3868 T3866 dobj aversion,regulating
R2651 T3869 T3836 punct .,maps
R2652 T3871 T3872 nsubj This,is
R2653 T3873 T3874 det an,distinction
R2654 T3874 T3872 attr distinction,is
R2655 T3875 T3874 amod important,distinction
R2656 T3876 T3872 punct ", ",is
R2657 T3877 T3878 mark as,be
R2658 T3878 T3872 advcl be,is
R2659 T3879 T3880 det the,consumption
R2660 T3880 T3878 nsubj consumption,be
R2661 T3881 T3880 prep of,consumption
R2662 T3882 T3883 amod bitter,tasting
R2663 T3883 T3885 amod tasting,stimuli
R2664 T3884 T3883 punct -,tasting
R2665 T3885 T3881 pobj stimuli,of
R2666 T3886 T3878 aux can,be
R2667 T3887 T3878 acomp dependent,be
R2668 T3888 T3887 prep on,dependent
R2669 T3889 T3888 pobj factors,on
R2670 T3890 T3889 amod independent,factors
R2671 T3891 T3890 prep of,independent
R2672 T3892 T3891 pobj taste,of
R2673 T3893 T3889 punct ", ",factors
R2674 T3894 T3895 amod such,as
R2675 T3895 T3889 prep as,factors
R2676 T3896 T3895 pobj toxicity,as
R2677 T3897 T3898 punct [,29
R2678 T3898 T3878 parataxis 29,be
R2679 T3899 T3898 punct ],29
R2680 T3900 T3872 punct .,is
R2681 T3902 T3903 advcl Using,restricted
R2682 T3904 T3905 nummod 17,lines
R2683 T3905 T3902 dobj lines,Using
R2684 T3906 T3905 amod RI,lines
R2685 T3907 T3905 cc and,lines
R2686 T3908 T3909 nummod 762,markers
R2687 T3909 T3905 conj markers,lines
R2688 T3910 T3909 amod chromosomal,markers
R2689 T3911 T3903 punct ", ",restricted
R2690 T3912 T3903 nsubj we,restricted
R2691 T3913 T3903 aux have,restricted
R2692 T3914 T3915 det the,QTL
R2693 T3915 T3903 dobj QTL,restricted
R2694 T3916 T3915 compound quinine,QTL
R2695 T3917 T3915 compound taste,QTL
R2696 T3918 T3903 prep to,restricted
R2697 T3919 T3920 det a,region
R2698 T3920 T3918 pobj region,to
R2699 T3921 T3922 punct <,5
R2700 T3922 T3923 nummod 5,Mb
R2701 T3923 T3920 compound Mb,region
R2702 T3924 T3920 prep on,region
R2703 T3925 T3926 amod distal,chromosome
R2704 T3926 T3924 pobj chromosome,on
R2705 T3927 T3926 nummod 6,chromosome
R2706 T3928 T3929 dep that,contains
R2707 T3929 T3920 relcl contains,region
R2708 T3930 T3931 nummod 24,genes
R2709 T3931 T3929 dobj genes,contains
R2710 T3932 T3931 compound Tas2r,genes
R2711 T3933 T3903 punct .,restricted
R2712 T3935 T3936 advmod At,60
R2713 T3936 T3938 nummod 60,genes
R2714 T3937 T3936 advmod least,60
R2715 T3938 T3940 nsubj genes,lie
R2716 T3939 T3938 amod other,genes
R2717 T3940 T3942 ccomp lie,appear
R2718 T3941 T3940 advmod also,lie
R2719 T3943 T3940 prep within,lie
R2720 T3944 T3945 det this,interval
R2721 T3945 T3943 pobj interval,within
R2722 T3946 T3940 punct ", ",lie
R2723 T3947 T3940 prep including,lie
R2724 T3948 T3949 nummod two,genes
R2725 T3949 T3947 pobj genes,including
R2726 T3950 T3951 dep that,encode
R2727 T3951 T3949 relcl encode,genes
R2728 T3952 T3953 npadvmod proline,rich
R2729 T3953 T3955 amod rich,proteins
R2730 T3954 T3953 punct -,rich
R2731 T3955 T3951 dobj proteins,encode
R2732 T3956 T3955 amod salivary,proteins
R2733 T3957 T3955 punct ", ",proteins
R2734 T3958 T3955 appos Prp2,proteins
R2735 T3959 T3958 cc and,Prp2
R2736 T3960 T3958 conj Prh1,Prp2
R2737 T3961 T3942 punct ;,appear
R2738 T3962 T3963 det these,proteins
R2739 T3963 T3942 nsubj proteins,appear
R2740 T3964 T3965 aux to,play
R2741 T3965 T3942 xcomp play,appear
R2742 T3966 T3967 det no,role
R2743 T3967 T3965 dobj role,play
R2744 T3968 T3967 amod direct,role
R2745 T3969 T3965 prep in,play
R2746 T3970 T3971 amod bitter,taste
R2747 T3971 T3969 pobj taste,in
R2748 T3972 T3973 punct [,48
R2749 T3973 T3965 parataxis 48,play
R2750 T3974 T3973 punct ],48
R2751 T3975 T3942 punct .,appear
R2752 T3977 T3978 nsubj Tas2rs,are
R2753 T3979 T3980 det the,candidates
R2754 T3980 T3978 attr candidates,are
R2755 T3981 T3982 advmod most,likely
R2756 T3982 T3980 amod likely,candidates
R2757 T3983 T3980 prep for,candidates
R2758 T3984 T3985 det the,gene
R2759 T3985 T3983 pobj gene,for
R2760 T3986 T3985 nmod QHCl,gene
R2761 T3987 T3988 amod quantitative,trait
R2762 T3988 T3985 compound trait,gene
R2763 T3989 T3985 punct (,gene
R2764 T3990 T3985 nmod s,gene
R2765 T3991 T3985 punct ),gene
R2766 T3992 T3978 prep due,are
R2767 T3993 T3992 pcomp to,due
R2768 T3994 T3992 punct : ,due
R2769 T3995 T3996 punct (,1
R2770 T3996 T3997 meta 1,expression
R2771 T3997 T3992 pobj expression,due
R2772 T3998 T3996 punct ),1
R2773 T3999 T3997 poss their,expression
R2774 T4000 T3997 prep in,expression
R2775 T4001 T4002 compound taste,cells
R2776 T4002 T4000 pobj cells,in
R2777 T4003 T4002 compound receptor,cells
R2778 T4004 T3997 cc and,expression
R2779 T4005 T4006 punct (,2
R2780 T4006 T4007 meta 2,evidence
R2781 T4007 T3997 conj evidence,expression
R2782 T4008 T4006 punct ),2
R2783 T4009 T4007 amod genetic,evidence
R2784 T4010 T4009 cc and,genetic
R2785 T4011 T4009 conj functional,genetic
R2786 T4012 T4007 acl linking,evidence
R2787 T4013 T4012 dobj them,linking
R2788 T4014 T4012 prep to,linking
R2789 T4015 T4016 det the,detection
R2790 T4016 T4014 pobj detection,to
R2791 T4017 T4016 prep of,detection
R2792 T4018 T4019 det a,number
R2793 T4019 T4017 pobj number,of
R2794 T4020 T4019 prep of,number
R2795 T4021 T4022 amod bitter,taste
R2796 T4022 T4023 compound taste,stimuli
R2797 T4023 T4020 pobj stimuli,of
R2798 T4024 T3978 punct .,are
R2799 T4026 T4027 prep As,is
R2800 T4028 T4026 prep of,As
R2801 T4029 T4028 pcomp yet,of
R2802 T4030 T4027 expl there,is
R2803 T4031 T4032 det no,evidence
R2804 T4032 T4027 attr evidence,is
R2805 T4033 T4032 prep for,evidence
R2806 T4034 T4035 compound quinine,activation
R2807 T4035 T4033 pobj activation,for
R2808 T4036 T4035 prep of,activation
R2809 T4037 T4036 pobj T2Rs,of
R2810 T4038 T4027 prep from,is
R2811 T4039 T4040 amod functional,assays
R2812 T4040 T4038 pobj assays,from
R2813 T4041 T4040 prep of,assays
R2814 T4042 T4043 det these,receptors
R2815 T4043 T4041 pobj receptors,of
R2816 T4044 T4040 prep in,assays
R2817 T4045 T4046 amod heterologous,cells
R2818 T4046 T4044 pobj cells,in
R2819 T4047 T4046 cc or,cells
R2820 T4048 T4049 compound membrane,preparations
R2821 T4049 T4046 conj preparations,cells
R2822 T4050 T4027 punct ", ",is
R2823 T4051 T4052 advmod likely,due
R2824 T4052 T4027 prep due,is
R2825 T4053 T4052 pcomp to,due
R2826 T4054 T4055 det the,nature
R2827 T4055 T4052 pobj nature,due
R2828 T4056 T4055 amod lipophilic,nature
R2829 T4057 T4055 prep of,nature
R2830 T4058 T4057 pobj quinine,of
R2831 T4059 T4060 punct [,23
R2832 T4060 T4027 parataxis 23,is
R2833 T4061 T4060 punct ],23
R2834 T4062 T4027 punct .,is
R2835 T4064 T4065 advmod However,suggested
R2836 T4066 T4065 punct ", ",suggested
R2837 T4067 T4068 amod several,studies
R2838 T4068 T4065 nsubj studies,suggested
R2839 T4069 T4068 amod physiological,studies
R2840 T4070 T4065 aux have,suggested
R2841 T4071 T4072 mark that,activate
R2842 T4072 T4065 ccomp activate,suggested
R2843 T4073 T4072 nsubj quinine,activate
R2844 T4074 T4072 aux can,activate
R2845 T4075 T4072 advmod directly,activate
R2846 T4076 T4077 compound G,proteins
R2847 T4077 T4072 dobj proteins,activate
R2848 T4078 T4077 cc or,proteins
R2849 T4079 T4080 amod cationic,conductances
R2850 T4080 T4077 conj conductances,proteins
R2851 T4081 T4072 punct ", ",activate
R2852 T4082 T4072 cc or,activate
R2853 T4083 T4084 aux can,block
R2854 T4084 T4072 conj block,activate
R2855 T4085 T4086 nmod K,channels
R2856 T4086 T4084 dobj channels,block
R2857 T4087 T4085 punct +,K
R2858 T4088 T4084 prep in,block
R2859 T4089 T4090 compound taste,receptor
R2860 T4090 T4091 compound receptor,cells
R2861 T4091 T4088 pobj cells,in
R2862 T4092 T4093 punct [,34
R2863 T4093 T4084 parataxis 34,block
R2864 T4094 T4095 punct -,36
R2865 T4095 T4093 prep 36,34
R2866 T4096 T4093 punct ],34
R2867 T4097 T4065 punct .,suggested
R2868 T4099 T4100 mark While,indicates
R2869 T4100 T4103 advcl indicates,is
R2870 T4101 T4102 poss our,data
R2871 T4102 T4100 nsubj data,indicates
R2872 T4104 T4105 mark that,is
R2873 T4105 T4100 ccomp is,indicates
R2874 T4106 T4107 compound quinine,taste
R2875 T4107 T4105 nsubj taste,is
R2876 T4108 T4109 advmod largely,dependent
R2877 T4109 T4105 acomp dependent,is
R2878 T4110 T4109 npadvmod T2R,dependent
R2879 T4111 T4109 punct -,dependent
R2880 T4112 T4103 punct ", ",is
R2881 T4113 T4103 nsubj it,is
R2882 T4114 T4103 neg not,is
R2883 T4115 T4116 advmod exclusively,so
R2884 T4116 T4103 advmod so,is
R2885 T4117 T4103 punct .,is
R2886 T4119 T4120 prep For,exhibited
R2887 T4121 T4119 pobj example,For
R2888 T4122 T4120 punct ", ",exhibited
R2889 T4123 T4124 det the,lines
R2890 T4124 T4120 nsubj lines,exhibited
R2891 T4125 T4124 nmod BXD,lines
R2892 T4126 T4124 amod RI,lines
R2893 T4127 T4128 det a,range
R2894 T4128 T4120 dobj range,exhibited
R2895 T4129 T4128 prep of,range
R2896 T4130 T4131 compound quinine,sensitivity
R2897 T4131 T4129 pobj sensitivity,of
R2898 T4132 T4120 punct ", ",exhibited
R2899 T4133 T4120 prep with,exhibited
R2900 T4134 T4135 amod several,strains
R2901 T4135 T4136 nsubj strains,having
R2902 T4136 T4133 pcomp having,with
R2903 T4137 T4138 amod similar,sensitivities
R2904 T4138 T4136 dobj sensitivities,having
R2905 T4139 T4138 prep to,sensitivities
R2906 T4140 T4139 pobj that,to
R2907 T4141 T4140 prep of,that
R2908 T4142 T4141 pobj B6,of
R2909 T4143 T4136 punct ", ",having
R2910 T4144 T4145 det some,strains
R2911 T4145 T4136 npadvmod strains,having
R2912 T4146 T4145 prep with,strains
R2913 T4147 T4146 pobj sensitivities,with
R2914 T4148 T4147 amod similar,sensitivities
R2915 T4149 T4148 prep to,similar
R2916 T4150 T4149 pobj that,to
R2917 T4151 T4150 prep of,that
R2918 T4152 T4151 pobj D2,of
R2919 T4153 T4145 punct ", ",strains
R2920 T4154 T4145 cc and,strains
R2921 T4155 T4156 det a,group
R2922 T4156 T4145 conj group,strains
R2923 T4157 T4156 amod third,group
R2924 T4158 T4156 prep with,group
R2925 T4159 T4160 det a,phenotype
R2926 T4160 T4158 pobj phenotype,with
R2927 T4161 T4162 advmod more,intermediate
R2928 T4162 T4160 amod intermediate,phenotype
R2929 T4163 T4164 punct (,7
R2930 T4164 T4120 parataxis 7,exhibited
R2931 T4165 T4164 nmod Figures,7
R2932 T4166 T4164 nummod 1,7
R2933 T4167 T4164 punct ", ",7
R2934 T4168 T4164 punct ),7
R2935 T4169 T4120 punct .,exhibited
R2936 T4171 T4172 det This,observation
R2937 T4172 T4173 nsubj observation,is
R2938 T4174 T4173 acomp consistent,is
R2939 T4175 T4174 prep with,consistent
R2940 T4176 T4177 det a,basis
R2941 T4177 T4175 pobj basis,with
R2942 T4178 T4177 amod polygenic,basis
R2943 T4179 T4177 prep for,basis
R2944 T4180 T4181 compound quinine,taste
R2945 T4181 T4179 pobj taste,for
R2946 T4182 T4183 punct [,26
R2947 T4183 T4173 parataxis 26,is
R2948 T4184 T4183 nummod 16,26
R2949 T4185 T4183 punct ",",26
R2950 T4186 T4183 punct ],26
R2951 T4187 T4173 punct .,is
R2952 T4189 T4190 advmod Also,contain
R2953 T4191 T4190 punct ", ",contain
R2954 T4192 T4193 det a,QTL
R2955 T4193 T4190 nsubj QTL,contain
R2956 T4194 T4193 amod suggestive,QTL
R2957 T4195 T4193 prep on,QTL
R2958 T4196 T4195 pobj chromosome,on
R2959 T4197 T4196 nummod 8,chromosome
R2960 T4198 T4190 aux does,contain
R2961 T4199 T4190 neg not,contain
R2962 T4200 T4201 det any,genes
R2963 T4201 T4190 dobj genes,contain
R2964 T4202 T4201 compound Tas2r,genes
R2965 T4203 T4190 punct ", ",contain
R2966 T4204 T4190 cc but,contain
R2967 T4205 T4206 aux does,contain
R2968 T4206 T4190 conj contain,contain
R2969 T4207 T4208 det a,number
R2970 T4208 T4206 dobj number,contain
R2971 T4209 T4208 prep of,number
R2972 T4210 T4209 pobj genes,of
R2973 T4211 T4210 acl encoding,genes
R2974 T4212 T4213 compound ion,channels
R2975 T4213 T4211 dobj channels,encoding
R2976 T4214 T4213 punct ", ",channels
R2977 T4215 T4213 conj enzymes,channels
R2978 T4216 T4215 cc and,enzymes
R2979 T4217 T4215 conj members,enzymes
R2980 T4218 T4217 prep of,members
R2981 T4219 T4220 amod other,families
R2982 T4220 T4218 pobj families,of
R2983 T4221 T4220 compound receptor,families
R2984 T4222 T4223 punct (,data
R2985 T4223 T4206 meta data,contain
R2986 T4224 T4223 poss our,data
R2987 T4225 T4223 amod unpublished,data
R2988 T4226 T4223 punct ),data
R2989 T4227 T4190 punct .,contain
R2990 T4229 T4230 nsubj It,be
R2991 T4231 T4230 aux will,be
R2992 T4232 T4230 acomp interesting,be
R2993 T4233 T4234 aux to,determine
R2994 T4234 T4230 xcomp determine,be
R2995 T4235 T4236 mark whether,linked
R2996 T4236 T4234 advcl linked,determine
R2997 T4237 T4238 det this,QTL
R2998 T4238 T4236 nsubjpass QTL,linked
R2999 T4239 T4238 amod suggestive,QTL
R3000 T4240 T4236 auxpass is,linked
R3001 T4241 T4236 prep to,linked
R3002 T4242 T4243 compound quinine,taste
R3003 T4243 T4241 pobj taste,to
R3004 T4244 T4236 cc and,linked
R3005 T4245 T4246 punct ", ",is
R3006 T4246 T4236 conj is,linked
R3007 T4247 T4248 mark if,so
R3008 T4248 T4246 advcl so,is
R3009 T4249 T4246 punct ", ",is
R3010 T4250 T4246 mark whether,is
R3011 T4251 T4246 nsubj it,is
R3012 T4252 T4246 acomp specific,is
R3013 T4253 T4252 prep for,specific
R3014 T4254 T4255 det this,stimulus
R3015 T4255 T4253 pobj stimulus,for
R3016 T4256 T4255 amod single,stimulus
R3017 T4257 T4255 amod bitter,stimulus
R3018 T4258 T4252 cc or,specific
R3019 T4259 T4260 advmod more,broadly
R3020 T4260 T4261 advmod broadly,related
R3021 T4261 T4252 conj related,specific
R3022 T4262 T4261 prep to,related
R3023 T4263 T4264 det all,taste
R3024 T4264 T4262 pobj taste,to
R3025 T4265 T4264 amod bitter,taste
R3026 T4266 T4230 punct .,be
R3027 T4268 T4269 prep Of,was
R3028 T4270 T4271 det the,lines
R3029 T4271 T4268 pobj lines,Of
R3030 T4272 T4271 nummod 29,lines
R3031 T4273 T4271 nmod BXD,lines
R3032 T4274 T4271 amod RI,lines
R3033 T4275 T4271 acl examined,lines
R3034 T4276 T4269 punct ", ",was
R3035 T4277 T4269 expl there,was
R3036 T4278 T4279 det no,event
R3037 T4279 T4269 attr event,was
R3038 T4280 T4279 amod apparent,event
R3039 T4281 T4279 compound recombination,event
R3040 T4282 T4279 prep within,event
R3041 T4283 T4284 det the,cluster
R3042 T4284 T4282 pobj cluster,within
R3043 T4285 T4284 nmod chromosome,cluster
R3044 T4286 T4285 nummod 6,chromosome
R3045 T4287 T4284 compound Tas2r,cluster
R3046 T4288 T4269 punct .,was
R3047 T4290 T4291 mark While,facilitate
R3048 T4291 T4309 advcl facilitate,is
R3049 T4292 T4291 csubj increasing,facilitate
R3050 T4293 T4294 det the,number
R3051 T4294 T4292 dobj number,increasing
R3052 T4295 T4294 prep of,number
R3053 T4296 T4297 nmod BXD,lines
R3054 T4297 T4295 pobj lines,of
R3055 T4298 T4297 amod RI,lines
R3056 T4299 T4294 cc or,number
R3057 T4300 T4301 det the,number
R3058 T4301 T4294 conj number,number
R3059 T4302 T4301 prep of,number
R3060 T4303 T4302 pobj markers,of
R3061 T4304 T4303 acl used,markers
R3062 T4305 T4304 prep for,used
R3063 T4306 T4305 pcomp genotyping,for
R3064 T4307 T4306 dobj them,genotyping
R3065 T4308 T4291 aux would,facilitate
R3066 T4310 T4311 det the,definition
R3067 T4311 T4291 dobj definition,facilitate
R3068 T4312 T4311 prep of,definition
R3069 T4313 T4314 amod smaller,intervals
R3070 T4314 T4312 pobj intervals,of
R3071 T4315 T4314 compound QTL,intervals
R3072 T4316 T4309 punct ", ",is
R3073 T4317 T4309 prep in,is
R3074 T4318 T4319 det this,case
R3075 T4319 T4317 pobj case,in
R3076 T4320 T4321 predet such,effort
R3077 T4321 T4309 nsubj effort,is
R3078 T4322 T4321 det an,effort
R3079 T4323 T4309 acomp unlikely,is
R3080 T4324 T4325 aux to,permit
R3081 T4325 T4323 xcomp permit,unlikely
R3082 T4326 T4327 det the,identification
R3083 T4327 T4325 dobj identification,permit
R3084 T4328 T4327 prep of,identification
R3085 T4329 T4328 pobj one,of
R3086 T4330 T4329 cc or,one
R3087 T4331 T4332 det a,few
R3088 T4332 T4333 nmod few,Tas2rs
R3089 T4333 T4329 conj Tas2rs,one
R3090 T4334 T4329 acl involved,one
R3091 T4335 T4334 prep in,involved
R3092 T4336 T4337 compound quinine,taste
R3093 T4337 T4335 pobj taste,in
R3094 T4338 T4309 punct .,is
R3095 T4340 T4341 prep For,examined
R3096 T4341 T4345 ccomp examined,indicated
R3097 T4342 T4340 pobj example,For
R3098 T4343 T4341 punct ", ",examined
R3099 T4344 T4341 nsubj we,examined
R3100 T4346 T4347 nummod six,lines
R3101 T4347 T4341 dobj lines,examined
R3102 T4348 T4347 prep of,lines
R3103 T4349 T4350 nmod AXB,RIs
R3104 T4350 T4348 pobj RIs,of
R3105 T4351 T4349 cc and,AXB
R3106 T4352 T4349 conj BXA,AXB
R3107 T4353 T4350 prep with,RIs
R3108 T4354 T4355 amod reported,recombinations
R3109 T4355 T4353 pobj recombinations,with
R3110 T4356 T4355 prep around,recombinations
R3111 T4357 T4356 pobj D6Mit13,around
R3112 T4358 T4345 punct ;,indicated
R3113 T4359 T4360 det a,sampling
R3114 T4360 T4345 nsubj sampling,indicated
R3115 T4361 T4360 amod small,sampling
R3116 T4362 T4360 prep of,sampling
R3117 T4363 T4364 det the,Tas2rs
R3118 T4364 T4362 pobj Tas2rs,of
R3119 T4365 T4364 prep in,Tas2rs
R3120 T4366 T4367 det these,lines
R3121 T4367 T4365 pobj lines,in
R3122 T4368 T4367 amod RI,lines
R3123 T4369 T4345 advmod again,indicated
R3124 T4370 T4371 det no,recombinations
R3125 T4371 T4345 dobj recombinations,indicated
R3126 T4372 T4371 prep within,recombinations
R3127 T4373 T4374 det the,cluster
R3128 T4374 T4372 pobj cluster,within
R3129 T4375 T4374 compound Tas2r,cluster
R3130 T4376 T4377 punct (,shown
R3131 T4377 T4345 parataxis shown,indicated
R3132 T4378 T4377 nsubj data,shown
R3133 T4379 T4377 neg not,shown
R3134 T4380 T4377 punct ),shown
R3135 T4381 T4345 punct .,indicated
R3136 T4383 T4384 amod Behavioral,approaches
R3137 T4384 T4386 nsubj approaches,been
R3138 T4385 T4384 amod genetic,approaches
R3139 T4387 T4386 aux have,been
R3140 T4388 T4386 acomp invaluable,been
R3141 T4389 T4388 prep for,invaluable
R3142 T4390 T4389 pcomp identifying,for
R3143 T4391 T4390 dobj genes,identifying
R3144 T4392 T4391 acl involved,genes
R3145 T4393 T4392 prep in,involved
R3146 T4394 T4395 compound taste,function
R3147 T4395 T4393 pobj function,in
R3148 T4396 T4391 punct ", ",genes
R3149 T4397 T4398 amod such,as
R3150 T4398 T4391 prep as,genes
R3151 T4399 T4400 det the,gene
R3152 T4400 T4398 pobj gene,as
R3153 T4401 T4400 compound Tas1r3,gene
R3154 T4402 T4403 dep that,encodes
R3155 T4403 T4400 relcl encodes,gene
R3156 T4404 T4405 det a,receptor
R3157 T4405 T4403 dobj receptor,encodes
R3158 T4406 T4405 amod important,receptor
R3159 T4407 T4406 prep for,important
R3160 T4408 T4409 amod sweet,taste
R3161 T4409 T4407 pobj taste,for
R3162 T4410 T4408 cc and,sweet
R3163 T4411 T4408 conj umami,sweet
R3164 T4412 T4413 punct [,42
R3165 T4413 T4386 parataxis 42,been
R3166 T4414 T4413 punct ],42
R3167 T4415 T4386 punct .,been
R3168 T4417 T4418 amod Positional,cloning
R3169 T4418 T4419 nsubj cloning,permitted
R3170 T4420 T4419 advmod also,permitted
R3171 T4421 T4422 det the,identification
R3172 T4422 T4419 dobj identification,permitted
R3173 T4423 T4422 prep of,identification
R3174 T4424 T4425 det the,Tas2r
R3175 T4425 T4423 pobj Tas2r,of
R3176 T4426 T4425 amod responsible,Tas2r
R3177 T4427 T4426 prep for,responsible
R3178 T4428 T4429 det the,majority
R3179 T4429 T4427 pobj majority,for
R3180 T4430 T4429 prep of,majority
R3181 T4431 T4430 pobj variance,of
R3182 T4432 T4431 prep of,variance
R3183 T4433 T4434 nmod phenylthiocarbamide,sensitivity
R3184 T4434 T4432 pobj sensitivity,of
R3185 T4435 T4433 punct (,phenylthiocarbamide
R3186 T4436 T4433 appos PTC,phenylthiocarbamide
R3187 T4437 T4434 punct ),sensitivity
R3188 T4438 T4434 compound taste,sensitivity
R3189 T4439 T4434 prep in,sensitivity
R3190 T4440 T4439 pobj humans,in
R3191 T4441 T4442 punct [,18
R3192 T4442 T4419 parataxis 18,permitted
R3193 T4443 T4442 punct ],18
R3194 T4444 T4419 punct .,permitted
R3195 T4446 T4447 prep In,clustered
R3196 T4448 T4446 pobj both,In
R3197 T4449 T4448 prep of,both
R3198 T4450 T4451 det these,cases
R3199 T4451 T4449 pobj cases,of
R3200 T4452 T4447 punct ", ",clustered
R3201 T4453 T4447 advmod however,clustered
R3202 T4454 T4447 punct ", ",clustered
R3203 T4455 T4456 det the,genes
R3204 T4456 T4447 nsubjpass genes,clustered
R3205 T4457 T4456 acl linked,genes
R3206 T4458 T4457 prep to,linked
R3207 T4459 T4460 nmod saccharin,taste
R3208 T4460 T4458 pobj taste,to
R3209 T4461 T4459 cc or,saccharin
R3210 T4462 T4459 conj PTC,saccharin
R3211 T4463 T4447 auxpass were,clustered
R3212 T4464 T4447 neg not,clustered
R3213 T4465 T4447 advmod tightly,clustered
R3214 T4466 T4447 prep with,clustered
R3215 T4467 T4466 pobj paralogues,with
R3216 T4468 T4447 punct .,clustered
R3217 T4470 T4471 prep For,be
R3218 T4472 T4473 amod bitter,taste
R3219 T4473 T4470 pobj taste,For
R3220 T4474 T4471 punct ", ",be
R3221 T4475 T4476 amod behavioral,approaches
R3222 T4476 T4471 nsubj approaches,be
R3223 T4477 T4476 amod genetic,approaches
R3224 T4478 T4471 aux may,be
R3225 T4479 T4480 advmod more,useful
R3226 T4480 T4471 acomp useful,be
R3227 T4481 T4480 prep for,useful
R3228 T4482 T4481 pcomp identifying,for
R3229 T4483 T4482 dobj genes,identifying
R3230 T4484 T4483 acl encoding,genes
R3231 T4485 T4486 amod downstream,signaling
R3232 T4486 T4487 compound signaling,molecules
R3233 T4487 T4484 dobj molecules,encoding
R3234 T4488 T4487 cc or,molecules
R3235 T4489 T4487 conj components,molecules
R3236 T4490 T4489 prep of,components
R3237 T4491 T4492 npadvmod T2R,independent
R3238 T4492 T4494 amod independent,mechanisms
R3239 T4493 T4492 punct -,independent
R3240 T4494 T4490 pobj mechanisms,of
R3241 T4495 T4494 compound transduction,mechanisms
R3242 T4496 T4471 punct .,be
R3243 T4498 T4499 prep For,suggested
R3244 T4499 T4509 ccomp suggested,found
R3245 T4500 T4498 pobj example,For
R3246 T4501 T4499 punct ", ",suggested
R3247 T4502 T4503 det a,QTL
R3248 T4503 T4499 nsubjpass QTL,suggested
R3249 T4504 T4503 prep for,QTL
R3250 T4505 T4506 compound PROP,avoidance
R3251 T4506 T4504 pobj avoidance,for
R3252 T4507 T4499 aux has,suggested
R3253 T4508 T4499 auxpass been,suggested
R3254 T4510 T4499 prep on,suggested
R3255 T4511 T4510 pobj chromosome,on
R3256 T4512 T4511 nummod 7,chromosome
R3257 T4513 T4514 punct [,16
R3258 T4514 T4499 parataxis 16,suggested
R3259 T4515 T4514 punct ],16
R3260 T4516 T4499 punct ", ",suggested
R3261 T4517 T4499 cc and,suggested
R3262 T4518 T4519 nsubj we,observe
R3263 T4519 T4499 conj observe,suggested
R3264 T4520 T4521 det a,QTL
R3265 T4521 T4519 dobj QTL,observe
R3266 T4522 T4521 amod suggestive,QTL
R3267 T4523 T4521 prep for,QTL
R3268 T4524 T4525 compound quinine,taste
R3269 T4525 T4523 pobj taste,for
R3270 T4526 T4519 prep on,observe
R3271 T4527 T4526 pobj chromosome,on
R3272 T4528 T4527 nummod 8,chromosome
R3273 T4529 T4530 punct (,Figure
R3274 T4530 T4519 parataxis Figure,observe
R3275 T4531 T4530 nummod 2,Figure
R3276 T4532 T4530 punct ),Figure
R3277 T4533 T4509 punct ;,found
R3278 T4534 T4509 prep in,found
R3279 T4535 T4536 det neither,case
R3280 T4536 T4534 pobj case,in
R3281 T4537 T4509 auxpass are,found
R3282 T4538 T4509 nsubjpass Tas2rs,found
R3283 T4539 T4509 prep at,found
R3284 T4540 T4541 det these,loci
R3285 T4541 T4539 pobj loci,at
R3286 T4542 T4543 punct (,shown
R3287 T4543 T4509 parataxis shown,found
R3288 T4544 T4543 nsubj data,shown
R3289 T4545 T4543 neg not,shown
R3290 T4546 T4543 punct ),shown
R3291 T4547 T4509 punct .,found
R3292 T4549 T4550 nsubj It,is
R3293 T4551 T4552 advmod somewhat,puzzling
R3294 T4552 T4550 acomp puzzling,is
R3295 T4553 T4554 mark that,encode
R3296 T4554 T4550 ccomp encode,is
R3297 T4555 T4554 nsubj 22,encode
R3298 T4556 T4555 prep of,22
R3299 T4557 T4558 det the,Tas2rs
R3300 T4558 T4556 pobj Tas2rs,of
R3301 T4559 T4558 nummod 24,Tas2rs
R3302 T4560 T4558 acl examined,Tas2rs
R3303 T4561 T4562 amod variant,proteins
R3304 T4562 T4554 dobj proteins,encode
R3305 T4563 T4562 prep in,proteins
R3306 T4564 T4565 nmod B6,mice
R3307 T4565 T4563 pobj mice,in
R3308 T4566 T4564 cc and,B6
R3309 T4567 T4564 conj D2,B6
R3310 T4568 T4569 advmod even,exhibit
R3311 T4569 T4554 advcl exhibit,encode
R3312 T4570 T4569 mark though,exhibit
R3313 T4571 T4572 det these,strains
R3314 T4572 T4569 nsubj strains,exhibit
R3315 T4573 T4574 amod similar,responses
R3316 T4574 T4569 dobj responses,exhibit
R3317 T4575 T4574 compound taste,responses
R3318 T4576 T4574 prep to,responses
R3319 T4577 T4578 amod bitter,compounds
R3320 T4578 T4576 pobj compounds,to
R3321 T4579 T4580 amod such,as
R3322 T4580 T4578 prep as,compounds
R3323 T4581 T4580 pobj DB,as
R3324 T4582 T4581 cc or,DB
R3325 T4583 T4581 conj cyclohexamide,DB
R3326 T4584 T4585 punct [,47
R3327 T4585 T4554 parataxis 47,encode
R3328 T4586 T4585 punct ],47
R3329 T4587 T4550 punct .,is
R3330 T4589 T4590 advcl Taken,suggest
R3331 T4591 T4589 advmod together,Taken
R3332 T4592 T4590 punct ", ",suggest
R3333 T4593 T4594 det these,observations
R3334 T4594 T4590 nsubj observations,suggest
R3335 T4595 T4596 mark that,are
R3336 T4596 T4590 advcl are,suggest
R3337 T4597 T4596 nsubj Tas2rs,are
R3338 T4598 T4599 advmod quite,tolerant
R3339 T4599 T4596 acomp tolerant,are
R3340 T4600 T4599 prep of,tolerant
R3341 T4601 T4600 pobj variation,of
R3342 T4602 T4596 punct ", ",are
R3343 T4603 T4596 cc and,are
R3344 T4604 T4605 mark that,affect
R3345 T4605 T4596 conj affect,are
R3346 T4606 T4605 advmod perhaps,affect
R3347 T4607 T4605 nsubj most,affect
R3348 T4608 T4607 prep of,most
R3349 T4609 T4610 det the,differences
R3350 T4610 T4608 pobj differences,of
R3351 T4611 T4610 acl observed,differences
R3352 T4612 T4605 aux do,affect
R3353 T4613 T4605 neg not,affect
R3354 T4614 T4605 dobj domains,affect
R3355 T4615 T4614 amod important,domains
R3356 T4616 T4615 prep for,important
R3357 T4617 T4618 compound ligand,interactions
R3358 T4618 T4616 pobj interactions,for
R3359 T4619 T4618 cc or,interactions
R3360 T4620 T4621 npadvmod receptor,mediated
R3361 T4621 T4623 amod mediated,mechanisms
R3362 T4622 T4621 punct -,mediated
R3363 T4623 T4618 conj mechanisms,interactions
R3364 T4624 T4623 compound signaling,mechanisms
R3365 T4625 T4590 punct .,suggest
R3366 T4627 T4628 advmod Interestingly,affect
R3367 T4629 T4628 punct ", ",affect
R3368 T4630 T4631 nummod 23,%
R3369 T4631 T4628 nsubj %,affect
R3370 T4632 T4631 prep of,%
R3371 T4633 T4634 compound missense,mutations
R3372 T4634 T4632 pobj mutations,of
R3373 T4635 T4634 prep in,mutations
R3374 T4636 T4637 compound D2,Tas2rs
R3375 T4637 T4635 pobj Tas2rs,in
R3376 T4638 T4639 det the,loops
R3377 T4639 T4628 dobj loops,affect
R3378 T4640 T4639 amod first,loops
R3379 T4641 T4639 nummod two,loops
R3380 T4642 T4639 amod extracellular,loops
R3381 T4643 T4639 prep of,loops
R3382 T4644 T4645 det the,receptors
R3383 T4645 T4643 pobj receptors,of
R3384 T4646 T4628 punct .,affect
R3385 T4648 T4649 det These,loops
R3386 T4649 T4651 nsubjpass loops,shown
R3387 T4650 T4649 nummod two,loops
R3388 T4652 T4651 aux have,shown
R3389 T4653 T4651 auxpass been,shown
R3390 T4654 T4651 advmod recently,shown
R3391 T4655 T4656 aux to,affect
R3392 T4656 T4651 xcomp affect,shown
R3393 T4657 T4658 det the,profiles
R3394 T4658 T4656 dobj profiles,affect
R3395 T4659 T4658 compound ligand,profiles
R3396 T4660 T4658 compound response,profiles
R3397 T4661 T4658 prep of,profiles
R3398 T4662 T4663 det some,T2Rs
R3399 T4663 T4661 pobj T2Rs,of
R3400 T4664 T4665 punct [,23
R3401 T4665 T4656 parataxis 23,affect
R3402 T4666 T4665 punct ],23
R3403 T4667 T4651 punct .,shown
R3404 T4669 T4670 advmod More,systematic
R3405 T4670 T4671 amod systematic,analyses
R3406 T4671 T4672 nsubj analyses,are
R3407 T4673 T4671 prep of,analyses
R3408 T4674 T4675 compound structure,function
R3409 T4675 T4677 compound function,relationships
R3410 T4676 T4675 punct -,function
R3411 T4677 T4673 pobj relationships,of
R3412 T4678 T4677 prep between,relationships
R3413 T4679 T4680 det these,variants
R3414 T4680 T4678 pobj variants,between
R3415 T4681 T4680 compound T2R,variants
R3416 T4682 T4680 cc and,variants
R3417 T4683 T4684 det an,array
R3418 T4684 T4680 conj array,variants
R3419 T4685 T4684 prep of,array
R3420 T4686 T4687 amod bitter,stimuli
R3421 T4687 T4685 pobj stimuli,of
R3422 T4688 T4672 acomp necessary,are
R3423 T4689 T4690 aux to,determine
R3424 T4690 T4688 xcomp determine,necessary
R3425 T4691 T4692 det which,changes
R3426 T4692 T4693 dep changes,impact
R3427 T4693 T4690 ccomp impact,determine
R3428 T4694 T4693 aux may,impact
R3429 T4695 T4696 compound ligand,binding
R3430 T4696 T4693 dobj binding,impact
R3431 T4697 T4696 punct ", ",binding
R3432 T4698 T4696 conj interactions,binding
R3433 T4699 T4698 prep with,interactions
R3434 T4700 T4701 amod other,proteins
R3435 T4701 T4699 pobj proteins,with
R3436 T4702 T4698 punct ", ",interactions
R3437 T4703 T4698 cc or,interactions
R3438 T4704 T4705 amod overall,structure
R3439 T4705 T4698 conj structure,interactions
R3440 T4706 T4705 compound receptor,structure
R3441 T4707 T4672 punct .,are
R3442 T4709 T4710 amod Such,numbers
R3443 T4710 T4712 nsubj numbers,is
R3444 T4711 T4710 amod large,numbers
R3445 T4713 T4710 prep of,numbers
R3446 T4714 T4715 amod nonsynonymous,substitutions
R3447 T4715 T4713 pobj substitutions,of
R3448 T4716 T4715 prep between,substitutions
R3449 T4717 T4716 pobj orthologues,between
R3450 T4718 T4712 acomp suggestive,is
R3451 T4719 T4718 prep of,suggestive
R3452 T4720 T4721 amod adaptive,selection
R3453 T4721 T4719 pobj selection,of
R3454 T4722 T4712 punct .,is
R3455 T4724 T4725 nsubj Analysis,suggest
R3456 T4726 T4724 prep of,Analysis
R3457 T4727 T4728 compound sequence,diversity
R3458 T4728 T4726 pobj diversity,of
R3459 T4729 T4728 prep of,diversity
R3460 T4730 T4729 pobj Tas2rs,of
R3461 T4731 T4728 prep in,diversity
R3462 T4732 T4731 pobj humans,in
R3463 T4733 T4732 punct ", ",humans
R3464 T4734 T4735 amod great,apes
R3465 T4735 T4732 conj apes,humans
R3466 T4736 T4735 cc and,apes
R3467 T4737 T4738 amod old,world
R3468 T4738 T4739 compound world,monkeys
R3469 T4739 T4735 conj monkeys,apes
R3470 T4740 T4741 mark that,are
R3471 T4741 T4725 ccomp are,suggest
R3472 T4742 T4741 nsubj Tas2rs,are
R3473 T4743 T4741 acomp subject,are
R3474 T4744 T4743 prep to,subject
R3475 T4745 T4746 det some,degree
R3476 T4746 T4744 pobj degree,to
R3477 T4747 T4746 prep of,degree
R3478 T4748 T4749 amod positive,selection
R3479 T4749 T4747 pobj selection,of
R3480 T4750 T4751 punct [,44
R3481 T4751 T4741 parataxis 44,are
R3482 T4752 T4751 nummod 43,44
R3483 T4753 T4751 punct ",",44
R3484 T4754 T4751 punct ],44
R3485 T4755 T4725 punct .,suggest
R3486 T4757 T4758 advmod However,makes
R3487 T4759 T4758 punct ", ",makes
R3488 T4760 T4761 det the,fact
R3489 T4761 T4758 nsubj fact,makes
R3490 T4762 T4763 mark that,are
R3491 T4763 T4761 acl are,fact
R3492 T4764 T4765 det these,strains
R3493 T4765 T4763 nsubj strains,are
R3494 T4766 T4765 nummod two,strains
R3495 T4767 T4765 compound mouse,strains
R3496 T4768 T4765 punct ", ",strains
R3497 T4769 T4765 appos members,strains
R3498 T4770 T4769 prep of,members
R3499 T4771 T4772 det the,species
R3500 T4772 T4770 pobj species,of
R3501 T4773 T4772 amod same,species
R3502 T4774 T4763 punct ", ",are
R3503 T4775 T4776 advmod so,closely
R3504 T4776 T4777 advmod closely,related
R3505 T4777 T4763 acomp related,are
R3506 T4778 T4779 det this,explanation
R3507 T4779 T4780 nsubj explanation,problematic
R3508 T4780 T4758 ccomp problematic,makes
R3509 T4781 T4758 punct .,makes
R3510 T4783 T4784 nsubj It,is
R3511 T4785 T4784 acomp possible,is
R3512 T4786 T4787 mark that,inherited
R3513 T4787 T4784 ccomp inherited,is
R3514 T4788 T4789 nmod B6,mice
R3515 T4789 T4787 nsubj mice,inherited
R3516 T4790 T4788 cc and,B6
R3517 T4791 T4788 conj D2,B6
R3518 T4792 T4789 punct ", ",mice
R3519 T4793 T4794 dep which,have
R3520 T4794 T4789 relcl have,mice
R3521 T4795 T4796 det a,origin
R3522 T4796 T4794 dobj origin,have
R3523 T4797 T4796 amod similar,origin
R3524 T4798 T4794 prep in,have
R3525 T4799 T4800 det the,century
R3526 T4800 T4798 pobj century,in
R3527 T4801 T4800 amod early,century
R3528 T4802 T4800 amod 20th,century
R3529 T4803 T4787 punct ", ",inherited
R3530 T4804 T4805 amod different,haplotypes
R3531 T4805 T4787 dobj haplotypes,inherited
R3532 T4806 T4805 compound Tas2r,haplotypes
R3533 T4807 T4805 amod present,haplotypes
R3534 T4808 T4807 prep in,present
R3535 T4809 T4810 amod wild,populations
R3536 T4810 T4808 pobj populations,in
R3537 T4811 T4810 compound mouse,populations
R3538 T4812 T4813 amod prior,to
R3539 T4813 T4807 prep to,present
R3540 T4814 T4813 pobj inbreeding,to
R3541 T4815 T4784 punct .,is
R3566 T4895 T4896 prep In,found
R3567 T4897 T4895 pobj conclusion,In
R3568 T4898 T4896 punct ", ",found
R3569 T4899 T4896 nsubj we,found
R3570 T4900 T4896 aux have,found
R3571 T4901 T4902 mark that,is
R3572 T4902 T4896 ccomp is,found
R3573 T4903 T4902 nsubj sensitivity,is
R3574 T4904 T4903 prep to,sensitivity
R3575 T4905 T4906 det the,quinine
R3576 T4906 T4904 pobj quinine,to
R3577 T4907 T4908 amod bitter,tasting
R3578 T4908 T4906 nmod tasting,quinine
R3579 T4909 T4908 punct -,tasting
R3580 T4910 T4906 compound substance,quinine
R3581 T4911 T4902 punct ", ",is
R3582 T4912 T4913 mark as,assayed
R3583 T4913 T4902 advcl assayed,is
R3584 T4914 T4913 agent by,assayed
R3585 T4915 T4916 det a,test
R3586 T4916 T4914 pobj test,by
R3587 T4917 T4918 npadvmod taste,specific
R3588 T4918 T4916 amod specific,test
R3589 T4919 T4920 amod brief,access
R3590 T4920 T4916 compound access,test
R3591 T4921 T4920 punct -,access
R3592 T4922 T4902 punct ", ",is
R3593 T4923 T4924 det a,trait
R3594 T4924 T4902 attr trait,is
R3595 T4925 T4924 amod polygenic,trait
R3596 T4926 T4902 prep in,is
R3597 T4927 T4926 pobj mice,in
R3598 T4928 T4896 punct .,found
R3599 T4930 T4931 advmod However,is
R3600 T4932 T4931 punct ", ",is
R3601 T4933 T4934 det the,mechanism
R3602 T4934 T4931 nsubj mechanism,is
R3603 T4935 T4934 amod major,mechanism
R3604 T4936 T4934 prep for,mechanism
R3605 T4937 T4938 compound quinine,taste
R3606 T4938 T4939 compound taste,transduction
R3607 T4939 T4936 pobj transduction,for
R3608 T4940 T4931 advmod likely,is
R3609 T4941 T4931 acomp dependent,is
R3610 T4942 T4941 prep on,dependent
R3611 T4943 T4944 nummod one,receptors
R3612 T4944 T4942 pobj receptors,on
R3613 T4945 T4943 cc or,one
R3614 T4946 T4943 conj more,one
R3615 T4947 T4944 compound T2R,receptors
R3616 T4948 T4931 punct .,is
R3617 T4950 T4951 amod Most,genes
R3618 T4951 T4953 nsubj genes,are
R3619 T4952 T4951 compound Tas2r,genes
R3620 T4954 T4951 prep in,genes
R3621 T4955 T4956 det the,cluster
R3622 T4956 T4954 pobj cluster,in
R3623 T4957 T4956 amod distal,cluster
R3624 T4958 T4956 nmod chromosome,cluster
R3625 T4959 T4958 nummod 6,chromosome
R3626 T4960 T4953 acomp polymorphic,are
R3627 T4961 T4953 prep across,are
R3628 T4962 T4963 amod inbred,strains
R3629 T4963 T4961 pobj strains,across
R3630 T4964 T4963 prep of,strains
R3631 T4965 T4964 pobj mice,of
R3632 T4966 T4953 punct ", ",are
R3633 T4967 T4953 cc and,are
R3634 T4968 T4969 det this,cluster
R3635 T4969 T4970 nsubj cluster,forms
R3636 T4970 T4953 conj forms,are
R3637 T4971 T4972 det a,haplotype
R3638 T4972 T4970 dobj haplotype,forms
R3639 T4973 T4972 amod single,haplotype
R3640 T4974 T4975 dep that,correlates
R3641 T4975 T4972 relcl correlates,haplotype
R3642 T4976 T4975 prep with,correlates
R3643 T4977 T4978 compound quinine,taste
R3644 T4978 T4979 compound taste,sensitivity
R3645 T4979 T4976 pobj sensitivity,with
R3646 T4980 T4970 punct .,forms
R3647 T4982 T4983 det The,differences
R3648 T4983 T4985 nsubj differences,suggests
R3649 T4984 T4983 amod numerous,differences
R3650 T4986 T4983 prep in,differences
R3651 T4987 T4988 compound T2R,sequence
R3652 T4988 T4986 pobj sequence,in
R3653 T4989 T4988 compound protein,sequence
R3654 T4990 T4983 prep between,differences
R3655 T4991 T4992 det these,strains
R3656 T4992 T4990 pobj strains,between
R3657 T4993 T4992 nummod two,strains
R3658 T4994 T4992 compound mouse,strains
R3659 T4995 T4996 mark that,are
R3660 T4996 T4985 ccomp are,suggests
R3661 T4997 T4996 nsubj T2Rs,are
R3662 T4998 T4999 advmod broadly,tuned
R3663 T4999 T5000 amod tuned,receptors
R3664 T5000 T4996 attr receptors,are
R3665 T5001 T5002 advmod quite,tolerant
R3666 T5002 T5000 amod tolerant,receptors
R3667 T5003 T5002 prep to,tolerant
R3668 T5004 T5005 compound sequence,variation
R3669 T5005 T5003 pobj variation,to
R3670 T5006 T4985 punct .,suggests
R3671 T5008 T5009 det This,tolerance
R3672 T5009 T5010 nsubj tolerance,help
R3673 T5011 T5010 aux may,help
R3674 T5012 T5013 aux to,preserve
R3675 T5013 T5010 xcomp preserve,help
R3676 T5014 T5015 det the,ability
R3677 T5015 T5013 dobj ability,preserve
R3678 T5016 T5015 prep of,ability
R3679 T5017 T5018 npadvmod T2R,expressing
R3680 T5018 T5020 amod expressing,cells
R3681 T5019 T5018 punct -,expressing
R3682 T5020 T5016 pobj cells,of
R3683 T5021 T5020 punct ", ",cells
R3684 T5022 T5023 amod bitter,sensitive
R3685 T5023 T5020 amod sensitive,cells
R3686 T5024 T5023 punct -,sensitive
R3687 T5025 T5020 compound taste,cells
R3688 T5026 T5027 aux to,respond
R3689 T5027 T5015 acl respond,ability
R3690 T5028 T5027 prep to,respond
R3691 T5029 T5030 det a,array
R3692 T5030 T5028 pobj array,to
R3693 T5031 T5030 amod wide,array
R3694 T5032 T5030 prep of,array
R3695 T5033 T5034 advmod potentially,toxic
R3696 T5034 T5035 amod toxic,stimuli
R3697 T5035 T5032 pobj stimuli,of
R3698 T5036 T5010 punct .,help
R3699 T5094 T5093 cc and,Mice
R3700 T5095 T5093 conj solutions,Mice
R3701 T5097 T5098 det A,total
R3702 T5098 T5099 nsubjpass total,tested
R3703 T5100 T5098 prep of,total
R3704 T5101 T5102 nummod 188,mice
R3705 T5102 T5100 pobj mice,of
R3706 T5103 T5102 amod adult,mice
R3707 T5104 T5102 amod male,mice
R3708 T5105 T5104 cc and,male
R3709 T5106 T5104 conj female,male
R3710 T5107 T5099 auxpass were,tested
R3711 T5108 T5099 advmod behaviorally,tested
R3712 T5109 T5099 prep in,tested
R3713 T5110 T5111 det these,experiments
R3714 T5111 T5109 pobj experiments,in
R3715 T5112 T5099 punct : ,tested
R3716 T5113 T5114 nummod 16,6J
R3717 T5114 T5099 dobj 6J,tested
R3718 T5115 T5114 compound C57BL,6J
R3719 T5116 T5114 punct /,6J
R3720 T5117 T5118 punct (,females
R3721 T5118 T5114 parataxis females,6J
R3722 T5119 T5118 dep B6,females
R3723 T5120 T5118 punct ;,females
R3724 T5121 T5122 nummod 9,males
R3725 T5122 T5118 dep males,females
R3726 T5123 T5118 punct ", ",females
R3727 T5124 T5118 nummod 7,females
R3728 T5125 T5118 punct ),females
R3729 T5126 T5114 punct ", ",6J
R3730 T5127 T5128 nummod 12,2J
R3731 T5128 T5114 conj 2J,6J
R3732 T5129 T5128 compound DBA,2J
R3733 T5130 T5128 punct /,2J
R3734 T5131 T5132 punct (,males
R3735 T5132 T5128 parataxis males,2J
R3736 T5133 T5134 nummod 6,females
R3737 T5134 T5132 dep females,males
R3738 T5135 T5132 punct ", ",males
R3739 T5136 T5132 nummod 6,males
R3740 T5137 T5132 punct ),males
R3741 T5138 T5128 punct ", ",2J
R3742 T5139 T5128 cc and,2J
R3743 T5140 T5141 nummod 90,Ty
R3744 T5141 T5144 nmod Ty,mice
R3745 T5142 T5141 nmod BXD,Ty
R3746 T5143 T5141 punct /,Ty
R3747 T5144 T5128 conj mice,2J
R3748 T5145 T5146 amod recombinant,inbred
R3749 T5146 T5144 amod inbred,mice
R3750 T5147 T5148 punct (,males
R3751 T5148 T5114 parataxis males,6J
R3752 T5149 T5150 nsubj average,5
R3753 T5150 T5148 ccomp 5,males
R3754 T5151 T5150 punct =,5
R3755 T5152 T5153 punct /,line
R3756 T5153 T5150 prep line,5
R3757 T5154 T5148 punct ;,males
R3758 T5155 T5148 nummod 64,males
R3759 T5156 T5148 punct ", ",males
R3760 T5157 T5158 nummod 26,females
R3761 T5158 T5148 appos females,males
R3762 T5159 T5148 punct ),males
R3763 T5160 T5114 prep from,6J
R3764 T5161 T5162 nummod 17,lines
R3765 T5162 T5160 pobj lines,from
R3766 T5163 T5162 amod unique,lines
R3767 T5164 T5162 punct (,lines
R3768 T5165 T5166 nummod 1,34
R3769 T5166 T5162 appos 34,lines
R3770 T5167 T5166 punct ", ",34
R3771 T5168 T5166 nummod 2,34
R3772 T5169 T5166 punct ", ",34
R3773 T5170 T5166 nummod 5,34
R3774 T5171 T5166 punct ", ",34
R3775 T5172 T5166 nummod 6,34
R3776 T5173 T5166 punct ", ",34
R3777 T5174 T5166 nummod 11,34
R3778 T5175 T5166 punct ", ",34
R3779 T5176 T5166 nummod 13,34
R3780 T5177 T5166 punct ", ",34
R3781 T5178 T5166 nummod 14,34
R3782 T5179 T5166 punct ", ",34
R3783 T5180 T5166 nummod 15,34
R3784 T5181 T5166 punct ", ",34
R3785 T5182 T5166 nummod 20,34
R3786 T5183 T5166 punct ", ",34
R3787 T5184 T5166 nummod 21,34
R3788 T5185 T5166 punct ", ",34
R3789 T5186 T5166 nummod 24,34
R3790 T5187 T5166 punct ", ",34
R3791 T5188 T5166 nummod 27,34
R3792 T5189 T5166 punct ", ",34
R3793 T5190 T5166 nummod 29,34
R3794 T5191 T5166 punct ", ",34
R3795 T5192 T5166 nummod 31,34
R3796 T5193 T5166 punct ", ",34
R3797 T5194 T5166 nummod 32,34
R3798 T5195 T5166 punct ", ",34
R3799 T5196 T5166 nummod 33,34
R3800 T5197 T5166 punct ", ",34
R3801 T5198 T5099 punct ),tested
R3802 T5199 T5099 punct .,tested
R3803 T5201 T5202 det All,mice
R3804 T5202 T5203 nsubjpass mice,obtained
R3805 T5204 T5203 auxpass were,obtained
R3806 T5205 T5203 advmod either,obtained
R3807 T5206 T5203 prep from,obtained
R3808 T5207 T5208 compound Jackson,Laboratories
R3809 T5208 T5206 pobj Laboratories,from
R3810 T5209 T5208 punct (,Laboratories
R3811 T5210 T5211 compound Bar,Harbor
R3812 T5211 T5208 npadvmod Harbor,Laboratories
R3813 T5212 T5208 punct ", ",Laboratories
R3814 T5213 T5208 npadvmod ME,Laboratories
R3815 T5214 T5203 punct ),obtained
R3816 T5215 T5203 punct ", ",obtained
R3817 T5216 T5203 cc or,obtained
R3818 T5217 T5218 auxpass were,bred
R3819 T5218 T5203 conj bred,obtained
R3820 T5219 T5218 prep from,bred
R3821 T5220 T5221 compound mating,pairs
R3822 T5221 T5219 pobj pairs,from
R3823 T5222 T5218 prep at,bred
R3824 T5223 T5222 pobj UTHSC,at
R3825 T5224 T5203 punct .,obtained
R3826 T5226 T5227 prep At,housed
R3827 T5228 T5226 pobj time,At
R3828 T5229 T5228 prep of,time
R3829 T5230 T5229 pobj testing,of
R3830 T5231 T5227 punct ", ",housed
R3831 T5232 T5227 nsubjpass mice,housed
R3832 T5233 T5227 auxpass were,housed
R3833 T5234 T5227 advmod individually,housed
R3834 T5235 T5227 prep in,housed
R3835 T5236 T5237 amod standard,cages
R3836 T5237 T5235 pobj cages,in
R3837 T5238 T5237 compound shoebox,cages
R3838 T5239 T5237 prep with,cages
R3839 T5240 T5241 compound woodchip,bedding
R3840 T5241 T5239 pobj bedding,with
R3841 T5242 T5241 cc and,bedding
R3842 T5243 T5244 advmod ad,libitum
R3843 T5244 T5245 amod libitum,food
R3844 T5245 T5241 conj food,bedding
R3845 T5246 T5247 punct (,diet
R3846 T5247 T5245 parataxis diet,food
R3847 T5248 T5247 nmod Teklad,diet
R3848 T5249 T5248 nummod 8640,Teklad
R3849 T5250 T5247 compound rodent,diet
R3850 T5251 T5247 punct ),diet
R3851 T5252 T5227 punct .,housed
R3852 T5254 T5255 compound Taste,stimuli
R3853 T5255 T5256 nsubjpass stimuli,made
R3854 T5257 T5255 acl used,stimuli
R3855 T5258 T5257 prep in,used
R3856 T5259 T5260 det this,experiment
R3857 T5260 T5258 pobj experiment,in
R3858 T5261 T5256 auxpass were,made
R3859 T5262 T5256 prep from,made
R3860 T5263 T5264 compound reagent,grade
R3861 T5264 T5266 compound grade,chemicals
R3862 T5265 T5264 punct -,grade
R3863 T5266 T5262 pobj chemicals,from
R3864 T5267 T5266 punct : ,chemicals
R3865 T5268 T5266 appos Sucrose,chemicals
R3866 T5269 T5268 punct ", ",Sucrose
R3867 T5270 T5271 compound denatonium,benzoate
R3868 T5271 T5268 conj benzoate,Sucrose
R3869 T5272 T5271 punct ", ",benzoate
R3870 T5273 T5274 nummod 6,propylthiouracil
R3871 T5274 T5271 conj propylthiouracil,benzoate
R3872 T5275 T5274 punct -,propylthiouracil
R3873 T5276 T5274 compound n,propylthiouracil
R3874 T5277 T5274 punct -,propylthiouracil
R3875 T5278 T5274 cc and,propylthiouracil
R3876 T5279 T5280 compound quinine,hydrochloride
R3877 T5280 T5274 conj hydrochloride,propylthiouracil
R3878 T5281 T5280 punct (,hydrochloride
R3879 T5282 T5283 compound Sigma,Corp.
R3880 T5283 T5280 npadvmod Corp.,hydrochloride
R3881 T5284 T5283 compound Aldrich,Corp.
R3882 T5285 T5283 punct ;,Corp.
R3883 T5286 T5287 compound St.,Louis
R3884 T5287 T5283 npadvmod Louis,Corp.
R3885 T5288 T5283 punct ", ",Corp.
R3886 T5289 T5283 npadvmod MO,Corp.
R3887 T5290 T5256 punct ),made
R3888 T5291 T5256 punct .,made
R3889 T5293 T5294 nsubjpass Concentrations,made
R3890 T5295 T5293 prep of,Concentrations
R3891 T5296 T5297 det each,solution
R3892 T5297 T5295 pobj solution,of
R3893 T5298 T5294 auxpass were,made
R3894 T5299 T5294 advmod fresh,made
R3895 T5300 T5294 advmod daily,made
R3896 T5301 T5294 advcl using,made
R3897 T5302 T5303 amod distilled,water
R3898 T5303 T5301 dobj water,using
R3899 T5304 T5294 punct ", ",made
R3900 T5305 T5294 cc and,made
R3901 T5306 T5307 det all,stimuli
R3902 T5307 T5309 nsubjpass stimuli,presented
R3903 T5308 T5307 compound taste,stimuli
R3904 T5309 T5294 conj presented,made
R3905 T5310 T5309 auxpass were,presented
R3906 T5311 T5309 prep at,presented
R3907 T5312 T5313 compound room,temperature
R3908 T5313 T5311 pobj temperature,at
R3909 T5314 T5309 punct .,presented
R3910 T5316 T5317 det All,protocols
R3911 T5317 T5319 nsubjpass protocols,approved
R3912 T5318 T5317 compound animal,protocols
R3913 T5320 T5319 auxpass were,approved
R3914 T5321 T5319 agent by,approved
R3915 T5322 T5323 det the,Committee
R3916 T5323 T5321 pobj Committee,by
R3917 T5324 T5323 nmod UTHSC,Committee
R3918 T5325 T5326 nmod Institutional,Animal
R3919 T5326 T5323 nmod Animal,Committee
R3920 T5327 T5326 appos care,Animal
R3921 T5328 T5327 cc and,care
R3922 T5329 T5327 conj Use,care
R3923 T5330 T5319 punct .,approved
R3924 T5393 T5394 amod Brief,access
R3925 T5394 T5396 compound access,tests
R3926 T5395 T5394 punct -,access
R3927 T5398 T5399 det All,tests
R3928 T5399 T5401 nsubjpass tests,conducted
R3929 T5400 T5399 amod behavioral,tests
R3930 T5402 T5401 auxpass were,conducted
R3931 T5403 T5401 prep in,conducted
R3932 T5404 T5405 det the,gustometer
R3933 T5405 T5403 pobj gustometer,in
R3934 T5406 T5407 advmod commercially,available
R3935 T5407 T5405 amod available,gustometer
R3936 T5408 T5409 nmod Davis,MS
R3937 T5409 T5405 nmod MS,gustometer
R3938 T5410 T5409 punct -,MS
R3939 T5411 T5409 nummod 160,MS
R3940 T5412 T5405 punct (,gustometer
R3941 T5413 T5414 compound DiLog,Instruments
R3942 T5414 T5405 npadvmod Instruments,gustometer
R3943 T5415 T5414 punct ", ",Instruments
R3944 T5416 T5414 npadvmod Inc.,Instruments
R3945 T5417 T5414 punct ", ",Instruments
R3946 T5418 T5414 npadvmod Tallahassee,Instruments
R3947 T5419 T5414 npadvmod FL,Instruments
R3948 T5420 T5401 punct ),conducted
R3949 T5421 T5401 punct .,conducted
R3950 T5423 T5424 amod Testing,procedures
R3951 T5424 T5425 nsubj procedures,were
R3952 T5426 T5425 acomp similar,were
R3953 T5427 T5426 prep to,similar
R3954 T5428 T5427 pobj those,to
R3955 T5429 T5428 acl described,those
R3956 T5430 T5429 advmod earlier,described
R3957 T5431 T5432 punct [,37
R3958 T5432 T5425 parataxis 37,were
R3959 T5433 T5432 nummod 29,37
R3960 T5434 T5432 punct ",",37
R3961 T5435 T5432 punct ],37
R3962 T5436 T5425 punct .,were
R3963 T5438 T5439 advmod Briefly,given
R3964 T5440 T5439 punct ", ",given
R3965 T5441 T5439 prep after,given
R3966 T5442 T5443 nummod 24,hours
R3967 T5443 T5441 pobj hours,after
R3968 T5444 T5443 prep of,hours
R3969 T5445 T5446 compound water,deprivation
R3970 T5446 T5444 pobj deprivation,of
R3971 T5447 T5439 punct ", ",given
R3972 T5448 T5449 compound naïve,mice
R3973 T5449 T5439 nsubjpass mice,given
R3974 T5450 T5439 auxpass are,given
R3975 T5451 T5452 det a,trial
R3976 T5452 T5439 dobj trial,given
R3977 T5453 T5452 amod single,trial
R3978 T5454 T5455 nummod 20,minute
R3979 T5455 T5452 compound minute,trial
R3980 T5456 T5455 punct -,minute
R3981 T5457 T5452 acl consisting,trial
R3982 T5458 T5457 prep of,consisting
R3983 T5459 T5458 pobj access,of
R3984 T5460 T5459 prep to,access
R3985 T5461 T5462 det a,bottle
R3986 T5462 T5460 pobj bottle,to
R3987 T5463 T5462 amod single,bottle
R3988 T5464 T5462 prep of,bottle
R3989 T5465 T5466 amod distilled,water
R3990 T5466 T5464 pobj water,of
R3991 T5467 T5468 punct (,training
R3992 T5468 T5452 parataxis training,trial
R3993 T5469 T5470 compound sipper,tube
R3994 T5470 T5468 compound tube,training
R3995 T5471 T5468 punct ),training
R3996 T5472 T5439 punct .,given
R3997 T5474 T5475 prep On,initiate
R3998 T5476 T5474 pobj day,On
R3999 T5477 T5476 nummod 2,day
R4000 T5478 T5475 punct ", ",initiate
R4001 T5479 T5475 nsubj mice,initiate
R4002 T5480 T5475 aux could,initiate
R4003 T5481 T5482 quantmod up,sixteen
R4004 T5482 T5484 nummod sixteen,trials
R4005 T5483 T5482 quantmod to,sixteen
R4006 T5484 T5475 dobj trials,initiate
R4007 T5485 T5486 nummod 5,s
R4008 T5486 T5484 compound s,trials
R4009 T5487 T5475 prep with,initiate
R4010 T5488 T5489 det a,lick
R4011 T5489 T5487 pobj lick,with
R4012 T5490 T5489 amod single,lick
R4013 T5491 T5489 prep to,lick
R4014 T5492 T5491 pobj one,to
R4015 T5493 T5492 prep of,one
R4016 T5494 T5495 nummod four,bottles
R4017 T5495 T5493 pobj bottles,of
R4018 T5496 T5495 acl containing,bottles
R4019 T5497 T5498 amod distilled,water
R4020 T5498 T5496 dobj water,containing
R4021 T5499 T5500 punct (,training
R4022 T5500 T5475 parataxis training,initiate
R4023 T5501 T5500 compound trial,training
R4024 T5502 T5500 punct ),training
R4025 T5503 T5475 punct .,initiate
R4026 T5505 T5506 nsubj Testing,occurred
R4027 T5507 T5506 prep in,occurred
R4028 T5508 T5509 nmod sessions,3
R4029 T5509 T5507 pobj 3,in
R4030 T5510 T5509 cc and,3
R4031 T5511 T5509 conj 4,3
R4032 T5512 T5506 punct ", ",occurred
R4033 T5513 T5506 prep with,occurred
R4034 T5514 T5515 nummod one,session
R4035 T5515 T5513 pobj session,with
R4036 T5516 T5515 compound test,session
R4037 T5517 T5515 prep per,session
R4038 T5518 T5517 pobj day,per
R4039 T5519 T5515 prep per,session
R4040 T5520 T5519 pobj mouse,per
R4041 T5521 T5506 punct .,occurred
R4042 T5523 T5524 nsubj Trials,were
R4043 T5524 T5525 ccomp were,closed
R4044 T5526 T5527 nummod 5,s
R4045 T5527 T5524 attr s,were
R4046 T5528 T5527 prep in,s
R4047 T5529 T5528 pobj length,in
R4048 T5530 T5524 prep with,were
R4049 T5531 T5532 det an,interval
R4050 T5532 T5530 pobj interval,with
R4051 T5533 T5532 amod inter-trial,interval
R4052 T5534 T5532 prep of,interval
R4053 T5535 T5536 nummod 10,s
R4054 T5536 T5534 pobj s,of
R4055 T5537 T5524 punct ", ",were
R4056 T5538 T5524 cc and,were
R4057 T5539 T5540 nsubj mice,had
R4058 T5540 T5524 conj had,were
R4059 T5541 T5542 quantmod up,120
R4060 T5542 T5544 nummod 120,s
R4061 T5543 T5542 quantmod to,120
R4062 T5544 T5540 dobj s,had
R4063 T5545 T5546 aux to,initiate
R4064 T5546 T5540 advcl initiate,had
R4065 T5547 T5548 det a,trial
R4066 T5548 T5546 dobj trial,initiate
R4067 T5549 T5525 punct ;,closed
R4068 T5550 T5551 mark if,initiated
R4069 T5551 T5525 advcl initiated,closed
R4070 T5552 T5553 det a,trial
R4071 T5553 T5551 nsubjpass trial,initiated
R4072 T5554 T5551 auxpass was,initiated
R4073 T5555 T5551 neg not,initiated
R4074 T5556 T5551 prep during,initiated
R4075 T5557 T5558 det this,interval
R4076 T5558 T5556 pobj interval,during
R4077 T5559 T5525 punct ", ",closed
R4078 T5560 T5561 det the,shutter
R4079 T5561 T5525 nsubj shutter,closed
R4080 T5562 T5525 prep for,closed
R4081 T5563 T5564 nummod 10,s
R4082 T5564 T5562 pobj s,for
R4083 T5565 T5525 cc and,closed
R4084 T5566 T5567 det the,trial
R4085 T5567 T5569 nsubjpass trial,presented
R4086 T5568 T5567 amod next,trial
R4087 T5569 T5525 conj presented,closed
R4088 T5570 T5569 auxpass was,presented
R4089 T5571 T5525 punct .,closed
R4090 T5573 T5574 nsubjpass Mice,tested
R4091 T5575 T5574 auxpass were,tested
R4092 T5576 T5574 prep with,tested
R4093 T5577 T5578 nummod 2,concentrations
R4094 T5578 T5576 pobj concentrations,with
R4095 T5579 T5578 appos each,concentrations
R4096 T5580 T5578 prep of,concentrations
R4097 T5581 T5582 nummod 4,stimuli
R4098 T5582 T5580 pobj stimuli,of
R4099 T5583 T5582 amod different,stimuli
R4100 T5584 T5582 compound taste,stimuli
R4101 T5585 T5586 punct [,QHCl
R4102 T5586 T5574 parataxis QHCl,tested
R4103 T5587 T5588 nummod 1,mM
R4104 T5588 T5586 compound mM,QHCl
R4105 T5589 T5587 cc and,1
R4106 T5590 T5587 conj 3,1
R4107 T5591 T5586 punct ", ",QHCl
R4108 T5592 T5593 nummod 1,mM
R4109 T5593 T5596 compound mM,DB
R4110 T5594 T5592 cc and,1
R4111 T5595 T5592 conj 3,1
R4112 T5596 T5586 conj DB,QHCl
R4113 T5597 T5596 punct ", ",DB
R4114 T5598 T5599 nummod 3,mM
R4115 T5599 T5602 compound mM,PROP
R4116 T5600 T5598 cc and,3
R4117 T5601 T5598 conj 10,3
R4118 T5602 T5596 conj PROP,DB
R4119 T5603 T5604 punct (,data
R4120 T5604 T5602 meta data,PROP
R4121 T5605 T5604 amod unpublished,data
R4122 T5606 T5604 punct ),data
R4123 T5607 T5602 punct ", ",PROP
R4124 T5608 T5602 cc and,PROP
R4125 T5609 T5610 nummod 0.01,M
R4126 T5610 T5613 compound M,sucrose
R4127 T5611 T5609 cc and,0.01
R4128 T5612 T5609 conj 0.1,0.01
R4129 T5613 T5602 conj sucrose,PROP
R4130 T5614 T5613 punct ],sucrose
R4131 T5615 T5574 punct .,tested
R4132 T5617 T5618 compound Stimulus,trials
R4133 T5618 T5619 nsubjpass trials,presented
R4134 T5620 T5619 auxpass were,presented
R4135 T5621 T5619 prep in,presented
R4136 T5622 T5623 nummod 3,blocks
R4137 T5623 T5621 pobj blocks,in
R4138 T5624 T5623 prep of,blocks
R4139 T5625 T5626 nummod 8,trials
R4140 T5626 T5624 pobj trials,of
R4141 T5627 T5619 punct ", ",presented
R4142 T5628 T5619 prep for,presented
R4143 T5629 T5630 det a,total
R4144 T5630 T5628 pobj total,for
R4145 T5631 T5630 prep of,total
R4146 T5632 T5633 nummod 24,trials
R4147 T5633 T5631 pobj trials,of
R4148 T5634 T5633 amod possible,trials
R4149 T5635 T5633 prep per,trials
R4150 T5636 T5637 compound test,session
R4151 T5637 T5635 pobj session,per
R4152 T5638 T5619 punct .,presented
R4153 T5640 T5641 det Each,block
R4154 T5641 T5642 nsubj block,consisted
R4155 T5643 T5642 prep of,consisted
R4156 T5644 T5645 det each,concentration
R4157 T5645 T5643 pobj concentration,of
R4158 T5646 T5645 prep of,concentration
R4159 T5647 T5646 pobj stimulus,of
R4160 T5648 T5645 cc plus,concentration
R4161 T5649 T5650 nummod four,presentations
R4162 T5650 T5645 conj presentations,concentration
R4163 T5651 T5650 prep of,presentations
R4164 T5652 T5653 amod distilled,water
R4165 T5653 T5651 pobj water,of
R4166 T5654 T5645 prep in,concentration
R4167 T5655 T5656 amod random,order
R4168 T5656 T5654 pobj order,in
R4169 T5657 T5642 punct .,consisted
R4170 T5659 T5660 amod Individual,mice
R4171 T5660 T5661 nsubjpass mice,tested
R4172 T5662 T5661 auxpass were,tested
R4173 T5663 T5661 advmod also,tested
R4174 T5664 T5661 prep in,tested
R4175 T5665 T5666 amod random,order
R4176 T5666 T5664 pobj order,in
R4177 T5667 T5661 punct .,tested
R4178 T5669 T5670 det The,measure
R4179 T5670 T5672 nsubj measure,was
R4180 T5671 T5670 amod dependent,measure
R4181 T5673 T5670 prep for,measure
R4182 T5674 T5673 pobj each,for
R4183 T5675 T5670 acl computed,measure
R4184 T5676 T5675 prep for,computed
R4185 T5677 T5678 det each,mouse
R4186 T5678 T5676 pobj mouse,for
R4187 T5679 T5680 det the,ratio
R4188 T5680 T5672 attr ratio,was
R4189 T5681 T5680 compound lick,ratio
R4190 T5682 T5680 punct (,ratio
R4191 T5683 T5684 amod average,number
R4192 T5684 T5680 appos number,ratio
R4193 T5685 T5684 prep of,number
R4194 T5686 T5685 pobj licks,of
R4195 T5687 T5686 prep to,licks
R4196 T5688 T5687 pobj stimulus,to
R4197 T5689 T5688 punct x,stimulus
R4198 T5690 T5691 punct /,number
R4199 T5691 T5684 prep number,number
R4200 T5692 T5691 amod average,number
R4201 T5693 T5691 prep of,number
R4202 T5694 T5693 pobj licks,of
R4203 T5695 T5694 prep to,licks
R4204 T5696 T5695 pobj water,to
R4205 T5697 T5672 punct ),was
R4206 T5698 T5699 advmod where,is
R4207 T5699 T5672 advcl is,was
R4208 T5700 T5699 nsubj x,is
R4209 T5701 T5702 det a,concentration
R4210 T5702 T5699 attr concentration,is
R4211 T5703 T5702 amod given,concentration
R4212 T5704 T5702 prep of,concentration
R4213 T5705 T5704 pobj stimulus,of
R4214 T5706 T5699 cc and,is
R4215 T5707 T5708 det the,number
R4216 T5708 T5710 nsubjpass number,derived
R4217 T5709 T5708 amod average,number
R4218 T5710 T5699 conj derived,is
R4219 T5711 T5708 prep of,number
R4220 T5712 T5711 pobj licks,of
R4221 T5713 T5712 prep to,licks
R4222 T5714 T5713 pobj water,to
R4223 T5715 T5710 auxpass is,derived
R4224 T5716 T5710 prep from,derived
R4225 T5717 T5718 det the,trials
R4226 T5718 T5716 pobj trials,from
R4227 T5719 T5718 compound water,trials
R4228 T5720 T5710 prep during,derived
R4229 T5721 T5722 det both,sessions
R4230 T5722 T5720 pobj sessions,during
R4231 T5723 T5722 compound test,sessions
R4232 T5724 T5672 punct .,was
R4233 T5726 T5727 amod Lick,ratio
R4234 T5727 T5728 compound ratio,data
R4235 T5728 T5729 nsubjpass data,compiled
R4236 T5730 T5728 prep for,data
R4237 T5731 T5732 det each,stimulus
R4238 T5732 T5730 pobj stimulus,for
R4239 T5733 T5729 auxpass were,compiled
R4240 T5734 T5729 prep for,compiled
R4241 T5735 T5736 det all,mice
R4242 T5736 T5734 pobj mice,for
R4243 T5737 T5736 amod individual,mice
R4244 T5738 T5729 punct ", ",compiled
R4245 T5739 T5729 cc and,compiled
R4246 T5740 T5741 nsubjpass means,prepared
R4247 T5741 T5729 conj prepared,compiled
R4248 T5742 T5741 auxpass were,prepared
R4249 T5743 T5741 prep for,prepared
R4250 T5744 T5745 det each,strain
R4251 T5745 T5743 pobj strain,for
R4252 T5746 T5741 punct .,prepared
R4253 T5748 T5749 nmod B6,comparisons
R4254 T5749 T5752 nsubjpass comparisons,made
R4255 T5750 T5748 cc vs.,B6
R4256 T5751 T5748 conj D2,B6
R4257 T5753 T5754 punct (,Fig.
R4258 T5754 T5749 parataxis Fig.,comparisons
R4259 T5755 T5754 nummod 1A,Fig.
R4260 T5756 T5754 punct ),Fig.
R4261 T5757 T5752 auxpass were,made
R4262 T5758 T5752 advcl using,made
R4263 T5759 T5760 amod main,effects
R4264 T5760 T5761 compound effects,ANOVA
R4265 T5761 T5758 dobj ANOVA,using
R4266 T5762 T5752 punct .,made
R4267 T5764 T5765 compound Lick,ratios
R4268 T5765 T5766 nsubj ratios,were
R4269 T5767 T5765 prep for,ratios
R4270 T5768 T5769 amod individual,mice
R4271 T5769 T5767 pobj mice,for
R4272 T5770 T5765 prep to,ratios
R4273 T5771 T5770 pobj sucrose,to
R4274 T5772 T5766 advmod generally,were
R4275 T5773 T5774 punct ~,1.0
R4276 T5774 T5766 attr 1.0,were
R4277 T5775 T5776 punct (,shown
R4278 T5776 T5766 parataxis shown,were
R4279 T5777 T5776 nsubj data,shown
R4280 T5778 T5776 neg not,shown
R4281 T5779 T5776 punct ),shown
R4282 T5780 T5766 punct ", ",were
R4283 T5781 T5766 advcl indicating,were
R4284 T5782 T5783 mark that,licked
R4285 T5783 T5781 ccomp licked,indicating
R4286 T5784 T5785 preconj either,concentration
R4287 T5785 T5783 nsubjpass concentration,licked
R4288 T5786 T5785 prep of,concentration
R4289 T5787 T5788 det this,compound
R4290 T5788 T5786 pobj compound,of
R4291 T5789 T5783 auxpass was,licked
R4292 T5790 T5783 prep at,licked
R4293 T5791 T5792 det a,rate
R4294 T5792 T5790 pobj rate,at
R4295 T5793 T5792 amod similar,rate
R4296 T5794 T5792 prep to,rate
R4297 T5795 T5794 pobj water,to
R4298 T5796 T5783 agent by,licked
R4299 T5797 T5798 det these,animals
R4300 T5798 T5796 pobj animals,by
R4301 T5799 T5798 amod thirsty,animals
R4302 T5800 T5766 punct .,were
R4303 T5802 T5803 det This,stimulus
R4304 T5803 T5804 nsubjpass stimulus,intended
R4305 T5805 T5804 auxpass was,intended
R4306 T5806 T5804 prep as,intended
R4307 T5807 T5808 det a,stimulus
R4308 T5808 T5806 pobj stimulus,as
R4309 T5809 T5808 punct """",stimulus
R4310 T5810 T5808 amod neutral,stimulus
R4311 T5811 T5808 punct """",stimulus
R4312 T5812 T5808 punct ", ",stimulus
R4313 T5813 T5808 cc albeit,stimulus
R4314 T5814 T5808 conj one,stimulus
R4315 T5815 T5816 dep that,has
R4316 T5816 T5814 relcl has,one
R4317 T5817 T5818 amod different,properties
R4318 T5818 T5816 dobj properties,has
R4319 T5819 T5818 amod sensory,properties
R4320 T5820 T5818 prep than,properties
R4321 T5821 T5820 pobj water,than
R4322 T5822 T5804 punct ", ",intended
R4323 T5823 T5804 cc and,intended
R4324 T5824 T5825 advmod therefore,analyzed
R4325 T5825 T5804 conj analyzed,intended
R4326 T5826 T5825 neg not,analyzed
R4327 T5827 T5825 advmod further,analyzed
R4328 T5828 T5804 punct .,intended
R4329 T5830 T5831 nsubjpass This,done
R4330 T5831 T5833 ccomp done,is
R4331 T5832 T5831 auxpass was,done
R4332 T5834 T5835 aux to,encourage
R4333 T5835 T5831 advcl encourage,done
R4334 T5836 T5835 dobj sampling,encourage
R4335 T5837 T5836 prep on,sampling
R4336 T5838 T5839 punct """",trials
R4337 T5839 T5837 pobj trials,on
R4338 T5840 T5839 amod non-water,trials
R4339 T5841 T5839 punct """",trials
R4340 T5842 T5831 punct ", ",done
R4341 T5843 T5844 mark as,is
R4342 T5844 T5831 advcl is,done
R4343 T5845 T5844 expl there,is
R4344 T5846 T5847 det some,evidence
R4345 T5847 T5844 attr evidence,is
R4346 T5848 T5849 mark that,detect
R4347 T5849 T5847 acl detect,evidence
R4348 T5850 T5849 nsubj mice,detect
R4349 T5851 T5852 amod distilled,water
R4350 T5852 T5849 dobj water,detect
R4351 T5853 T5851 cc vs.,distilled
R4352 T5854 T5851 conj adulterated,distilled
R4353 T5855 T5849 prep in,detect
R4354 T5856 T5857 amod brief,access
R4355 T5857 T5859 compound access,tests
R4356 T5858 T5857 punct -,access
R4357 T5859 T5855 pobj tests,in
R4358 T5860 T5859 compound taste,tests
R4359 T5861 T5849 prep based,detect
R4360 T5862 T5861 prep on,based
R4361 T5863 T5864 amod olfactory,clues
R4362 T5864 T5862 pobj clues,on
R4363 T5865 T5833 punct ;,is
R4364 T5866 T5833 expl there,is
R4365 T5867 T5868 det no,evidence
R4366 T5868 T5833 attr evidence,is
R4367 T5869 T5870 mark that,detect
R4368 T5870 T5868 acl detect,evidence
R4369 T5871 T5870 nsubj mice,detect
R4370 T5872 T5870 aux can,detect
R4371 T5873 T5870 cc or,detect
R4372 T5874 T5870 conj distinguish,detect
R4373 T5875 T5874 prep among,distinguish
R4374 T5876 T5875 pobj concentrations,among
R4375 T5877 T5876 prep of,concentrations
R4376 T5878 T5879 det a,stimulus
R4377 T5879 T5877 pobj stimulus,of
R4378 T5880 T5879 amod particular,stimulus
R4379 T5881 T5882 punct [,37
R4380 T5882 T5833 parataxis 37,is
R4381 T5883 T5882 punct ],37
R4382 T5884 T5833 punct .,is
R4383 T5902 T5903 compound QTL,mapping
R4384 T5905 T5906 compound Linkage,analysis
R4385 T5906 T5907 nsubjpass analysis,conducted
R4386 T5908 T5907 auxpass was,conducted
R4387 T5909 T5907 prep on,conducted
R4388 T5910 T5911 compound BXD,mice
R4389 T5911 T5909 pobj mice,on
R4390 T5912 T5907 advcl using,conducted
R4391 T5913 T5914 advmod freely,available
R4392 T5914 T5915 amod available,software
R4393 T5915 T5912 dobj software,using
R4394 T5916 T5917 punct (,38
R4395 T5917 T5915 parataxis 38,software
R4396 T5918 T5919 compound Map,Manager
R4397 T5919 T5920 compound Manager,QTX
R4398 T5920 T5917 dep QTX,38
R4399 T5921 T5917 punct [,38
R4400 T5922 T5917 punct ],38
R4401 T5923 T5917 punct ),38
R4402 T5924 T5915 punct ", ",software
R4403 T5925 T5915 cc and,software
R4404 T5926 T5927 compound BXD,data
R4405 T5927 T5915 conj data,software
R4406 T5928 T5927 compound genotype,data
R4407 T5929 T5927 acl shared,data
R4408 T5930 T5929 agent by,shared
R4409 T5931 T5932 compound Robert,Williams
R4410 T5932 T5930 pobj Williams,by
R4411 T5933 T5932 compound W.,Williams
R4412 T5934 T5932 punct ", ",Williams
R4413 T5935 T5936 nmod University,Center
R4414 T5936 T5932 npadvmod Center,Williams
R4415 T5937 T5935 prep of,University
R4416 T5938 T5937 pobj Tennessee,of
R4417 T5939 T5940 compound Health,Science
R4418 T5940 T5936 compound Science,Center
R4419 T5941 T5942 punct [,45
R4420 T5942 T5929 parataxis 45,shared
R4421 T5943 T5942 punct ],45
R4422 T5944 T5907 punct .,conducted
R4423 T5946 T5947 compound Simple,mapping
R4424 T5947 T5949 nsubjpass mapping,conducted
R4425 T5948 T5947 compound interval,mapping
R4426 T5950 T5949 auxpass was,conducted
R4427 T5951 T5949 punct .,conducted
R4428 T5953 T5954 det This,method
R4429 T5954 T5955 nsubj method,evaluates
R4430 T5956 T5957 det the,association
R4431 T5957 T5955 dobj association,evaluates
R4432 T5958 T5957 prep between,association
R4433 T5959 T5960 compound trait,values
R4434 T5960 T5958 pobj values,between
R4435 T5961 T5960 punct (,values
R4436 T5962 T5963 compound lick,ratios
R4437 T5963 T5960 appos ratios,values
R4438 T5964 T5960 punct ),values
R4439 T5965 T5960 cc and,values
R4440 T5966 T5967 amod expected,genotype
R4441 T5967 T5960 conj genotype,values
R4442 T5968 T5967 prep of,genotype
R4443 T5969 T5970 det a,locus
R4444 T5970 T5968 pobj locus,of
R4445 T5971 T5970 amod hypothetical,locus
R4446 T5972 T5970 amod quantitative,locus
R4447 T5973 T5970 compound trait,locus
R4448 T5974 T5970 punct (,locus
R4449 T5975 T5970 appos QTL,locus
R4450 T5976 T5958 punct ),between
R4451 T5977 T5955 prep at,evaluates
R4452 T5978 T5979 amod multiple,points
R4453 T5979 T5977 pobj points,at
R4454 T5980 T5979 compound analysis,points
R4455 T5981 T5979 prep between,points
R4456 T5982 T5983 det each,pair
R4457 T5983 T5981 pobj pair,between
R4458 T5984 T5983 prep of,pair
R4459 T5985 T5986 amod adjacent,loci
R4460 T5986 T5984 pobj loci,of
R4461 T5987 T5986 compound marker,loci
R4462 T5988 T5955 punct .,evaluates
R4463 T5990 T5991 det The,significance
R4464 T5991 T5992 nsubjpass significance,measured
R4465 T5993 T5991 prep of,significance
R4466 T5994 T5995 det each,association
R4467 T5995 T5993 pobj association,of
R4468 T5996 T5995 amod potential,association
R4469 T5997 T5992 auxpass is,measured
R4470 T5998 T5992 prep by,measured
R4471 T5999 T6000 det the,statistic
R4472 T6000 T5998 pobj statistic,by
R4473 T6001 T6000 compound likelihood,statistic
R4474 T6002 T6000 compound ratio,statistic
R4475 T6003 T6000 punct (,statistic
R4476 T6004 T6000 appos LRS,statistic
R4477 T6005 T6006 punct ;,46
R4478 T6006 T5992 parataxis 46,measured
R4479 T6007 T6006 advmod e.g.,46
R4480 T6008 T6006 punct [,46
R4481 T6009 T6006 punct ],46
R4482 T6010 T6006 punct ),46
R4483 T6011 T5992 punct .,measured
R4484 T6013 T6014 compound Permutation,analysis
R4485 T6014 T6015 nsubjpass analysis,used
R4486 T6016 T6017 punct (,2000
R4487 T6017 T6014 parataxis 2000,analysis
R4488 T6018 T6017 punct x,2000
R4489 T6019 T6017 punct ),2000
R4490 T6020 T6015 auxpass was,used
R4491 T6021 T6022 aux to,determine
R4492 T6022 T6015 advcl determine,used
R4493 T6023 T6024 npadvmod genome,wide
R4494 T6024 T6026 amod wide,criteria
R4495 T6025 T6024 punct -,wide
R4496 T6026 T6022 dobj criteria,determine
R4497 T6027 T6026 compound significance,criteria
R4498 T6028 T6022 prep for,determine
R4499 T6029 T6030 compound LRS,scores
R4500 T6030 T6028 pobj scores,for
R4501 T6031 T6015 punct .,used
R4502 T6033 T6034 nsubjpass Significance,set
R4503 T6035 T6034 auxpass was,set
R4504 T6036 T6034 prep at,set
R4505 T6037 T6038 nsubj p,0.05
R4506 T6038 T6036 pcomp 0.05,at
R4507 T6039 T6038 punct <,0.05
R4508 T6040 T6034 cc and,set
R4509 T6041 T6042 nsubj suggestive,refers
R4510 T6042 T6034 conj refers,set
R4511 T6043 T6042 prep to,refers
R4512 T6044 T6045 nsubj p,0.63
R4513 T6045 T6043 pcomp 0.63,to
R4514 T6046 T6045 punct <,0.63
R4515 T6047 T6042 punct .,refers
R4516 T6049 T6050 amod Additional,markers
R4517 T6050 T6051 nsubjpass markers,identified
R4518 T6052 T6050 acl used,markers
R4519 T6053 T6054 aux to,refine
R4520 T6054 T6052 advcl refine,used
R4521 T6055 T6056 det the,QTL
R4522 T6056 T6054 dobj QTL,refine
R4523 T6057 T6056 prep on,QTL
R4524 T6058 T6057 pobj chromosome,on
R4525 T6059 T6058 nummod 6,chromosome
R4526 T6060 T6051 auxpass were,identified
R4527 T6061 T6051 prep from,identified
R4528 T6062 T6063 det the,resources
R4529 T6063 T6061 pobj resources,from
R4530 T6064 T6065 compound Jackson,Laboratories
R4531 T6065 T6063 compound Laboratories,resources
R4532 T6066 T6063 compound online,resources
R4533 T6067 T6063 prep for,resources
R4534 T6068 T6069 det the,strains
R4535 T6069 T6067 pobj strains,for
R4536 T6070 T6069 nmod BXD,strains
R4537 T6071 T6070 amod RI,BXD
R4538 T6072 T6073 punct [,40
R4539 T6073 T6051 parataxis 40,identified
R4540 T6074 T6073 punct ],40
R4541 T6075 T6051 punct .,identified
R4542 T6124 T6123 prep of,Identification
R4543 T6125 T6126 compound T2R,alleles
R4544 T6126 T6124 pobj alleles,of
R4545 T6128 T6129 nsubjpass Oligonucleotides,based
R4546 T6130 T6129 auxpass were,based
R4547 T6131 T6129 prep on,based
R4548 T6132 T6133 amod published,B6
R4549 T6133 T6131 pobj B6,on
R4550 T6134 T6133 compound mTas2r,B6
R4551 T6135 T6133 cc or,B6
R4552 T6136 T6137 nummod 129,SvJ
R4553 T6137 T6139 compound SvJ,sequences
R4554 T6138 T6137 punct /,SvJ
R4555 T6139 T6133 conj sequences,B6
R4556 T6140 T6139 compound cDNA,sequences
R4557 T6141 T6131 cc or,on
R4558 T6142 T6131 conj on,on
R4559 T6143 T6144 det the,genome
R4560 T6144 T6142 pobj genome,on
R4561 T6145 T6144 amod public,genome
R4562 T6146 T6144 compound B6,genome
R4563 T6147 T6129 punct .,based
R4564 T6149 T6150 amod Entire,regions
R4565 T6150 T6152 nsubjpass regions,amplified
R4566 T6151 T6150 compound coding,regions
R4567 T6153 T6150 cc plus,regions
R4568 T6154 T6155 punct ~,50
R4569 T6155 T6156 nummod 50,kb
R4570 T6156 T6150 conj kb,regions
R4571 T6157 T6156 prep of,kb
R4572 T6158 T6159 amod flanking,sequence
R4573 T6159 T6157 pobj sequence,of
R4574 T6160 T6150 prep of,regions
R4575 T6161 T6162 det each,Tas2r
R4576 T6162 T6160 pobj Tas2r,of
R4577 T6163 T6164 amod single,exon
R4578 T6164 T6162 compound exon,Tas2r
R4579 T6165 T6164 punct -,exon
R4580 T6166 T6152 auxpass was,amplified
R4581 T6167 T6152 prep from,amplified
R4582 T6168 T6169 nmod D2,DNA
R4583 T6169 T6167 pobj DNA,from
R4584 T6170 T6168 cc or,D2
R4585 T6171 T6168 conj BXD,D2
R4586 T6172 T6169 amod RI,DNA
R4587 T6173 T6169 amod genomic,DNA
R4588 T6174 T6169 punct (,DNA
R4589 T6175 T6176 compound Jackson,Laboratories
R4590 T6176 T6169 npadvmod Laboratories,DNA
R4591 T6177 T6176 punct ", ",Laboratories
R4592 T6178 T6179 compound Bar,Harbor
R4593 T6179 T6176 npadvmod Harbor,Laboratories
R4594 T6180 T6176 punct ", ",Laboratories
R4595 T6181 T6176 npadvmod ME,Laboratories
R4596 T6182 T6152 punct ),amplified
R4597 T6183 T6152 prep by,amplified
R4598 T6184 T6185 compound polymerase,reaction
R4599 T6185 T6183 pobj reaction,by
R4600 T6186 T6185 compound chain,reaction
R4601 T6187 T6185 punct (,reaction
R4602 T6188 T6185 appos PCR,reaction
R4603 T6189 T6152 punct ),amplified
R4604 T6190 T6152 advcl using,amplified
R4605 T6191 T6192 det a,Complete
R4606 T6192 T6190 dobj Complete,using
R4607 T6193 T6194 amod high,fidelity
R4608 T6194 T6192 compound fidelity,Complete
R4609 T6195 T6194 punct -,fidelity
R4610 T6196 T6192 compound polymerase,Complete
R4611 T6197 T6192 compound TaqPro,Complete
R4612 T6198 T6192 punct (,Complete
R4613 T6199 T6200 compound Denville,Scientific
R4614 T6200 T6192 npadvmod Scientific,Complete
R4615 T6201 T6200 punct ", ",Scientific
R4616 T6202 T6203 compound South,Plainfield
R4617 T6203 T6200 npadvmod Plainfield,Scientific
R4618 T6204 T6200 punct ", ",Scientific
R4619 T6205 T6200 npadvmod NJ,Scientific
R4620 T6206 T6152 punct ),amplified
R4621 T6207 T6152 punct .,amplified
R4622 T6209 T6210 compound PCR,products
R4623 T6210 T6211 nsubjpass products,subcloned
R4624 T6212 T6211 auxpass were,subcloned
R4625 T6213 T6211 prep into,subcloned
R4626 T6214 T6213 pobj pGemT,into
R4627 T6215 T6214 punct -,pGemT
R4628 T6216 T6214 amod Easy,pGemT
R4629 T6217 T6214 punct (,pGemT
R4630 T6218 T6214 npadvmod Promega,pGemT
R4631 T6219 T6218 punct ", ",Promega
R4632 T6220 T6218 npadvmod Madison,Promega
R4633 T6221 T6218 punct ", ",Promega
R4634 T6222 T6218 npadvmod WI,Promega
R4635 T6223 T6211 punct ),subcloned
R4636 T6224 T6211 cc and,subcloned
R4637 T6225 T6211 conj sequenced,subcloned
R4638 T6226 T6225 prep at,sequenced
R4639 T6227 T6228 det the,Core
R4640 T6228 T6226 pobj Core,at
R4641 T6229 T6228 nmod University,Core
R4642 T6230 T6229 prep of,University
R4643 T6231 T6230 pobj Maryland,of
R4644 T6232 T6228 nmod School,Core
R4645 T6233 T6232 prep of,School
R4646 T6234 T6233 pobj Medicine,of
R4647 T6235 T6228 compound Biopolymer,Core
R4648 T6236 T6211 punct .,subcloned
R4649 T6238 T6239 det The,sequences
R4650 T6239 T6240 nsubjpass sequences,compared
R4651 T6241 T6239 prep of,sequences
R4652 T6242 T6243 compound D2,products
R4653 T6243 T6241 pobj products,of
R4654 T6244 T6240 auxpass were,compared
R4655 T6245 T6240 prep to,compared
R4656 T6246 T6247 compound B6,sequences
R4657 T6247 T6245 pobj sequences,to
R4658 T6248 T6247 amod available,sequences
R4659 T6249 T6248 prep in,available
R4660 T6250 T6249 pobj Genbank,in
R4661 T6251 T6252 punct (,see
R4662 T6252 T6240 parataxis see,compared
R4663 T6253 T6254 amod Additional,file
R4664 T6254 T6252 dobj file,see
R4665 T6255 T6254 nummod 2,file
R4666 T6256 T6252 punct ),see
R4667 T6257 T6240 punct ", ",compared
R4668 T6258 T6240 cc and,compared
R4669 T6259 T6260 nsubj polymorphisms,identified
R4670 T6260 T6240 conj identified,compared
R4671 T6261 T6260 punct .,identified
R4672 T6263 T6264 advmod When,possible
R4673 T6264 T6265 advcl possible,identified
R4674 T6266 T6265 punct ", ",identified
R4675 T6267 T6268 amod unique,sites
R4676 T6268 T6265 nsubjpass sites,identified
R4677 T6269 T6268 compound restriction,sites
R4678 T6270 T6265 auxpass were,identified
R4679 T6271 T6272 dep that,differentiated
R4680 T6272 T6265 ccomp differentiated,identified
R4681 T6273 T6274 nmod B6,alleles
R4682 T6274 T6272 dobj alleles,differentiated
R4683 T6275 T6273 cc and,B6
R4684 T6276 T6273 conj D2,B6
R4685 T6277 T6265 punct ", ",identified
R4686 T6278 T6265 cc and,identified
R4687 T6279 T6280 det the,endonucleases
R4688 T6280 T6283 nsubjpass endonucleases,used
R4689 T6281 T6280 amod corresponding,endonucleases
R4690 T6282 T6280 compound restriction,endonucleases
R4691 T6283 T6265 conj used,identified
R4692 T6284 T6283 auxpass were,used
R4693 T6285 T6283 prep in,used
R4694 T6286 T6287 amod diagnostic,digests
R4695 T6287 T6285 pobj digests,in
R4696 T6288 T6287 prep of,digests
R4697 T6289 T6290 compound Tas2r,cDNAs
R4698 T6290 T6288 pobj cDNAs,of
R4699 T6291 T6290 acl amplified,cDNAs
R4700 T6292 T6291 prep from,amplified
R4701 T6293 T6294 amod genomic,DNA
R4702 T6294 T6292 pobj DNA,from
R4703 T6295 T6294 prep of,DNA
R4704 T6296 T6297 det each,strain
R4705 T6297 T6295 pobj strain,of
R4706 T6298 T6299 nmod BXD,Ty
R4707 T6299 T6297 nmod Ty,strain
R4708 T6300 T6299 punct /,Ty
R4709 T6301 T6297 amod RI,strain
R4710 T6302 T6265 punct .,identified
R4711 T6304 T6305 prep For,considered
R4712 T6306 T6304 pobj Tas2r120,For
R4713 T6307 T6305 punct ", ",considered
R4714 T6308 T6309 det the,absence
R4715 T6309 T6305 nsubjpass absence,considered
R4716 T6310 T6309 prep of,absence
R4717 T6311 T6312 det a,product
R4718 T6312 T6310 pobj product,of
R4719 T6313 T6312 compound PCR,product
R4720 T6314 T6305 auxpass was,considered
R4721 T6315 T6305 oprd diagnostic,considered
R4722 T6316 T6315 prep of,diagnostic
R4723 T6317 T6318 det the,allele
R4724 T6318 T6316 pobj allele,of
R4725 T6319 T6318 compound D2,allele
R4726 T6320 T6305 punct .,considered
R4727 T6332 T6333 compound Lick,ratios
R4728 T6334 T6335 punct (,SE
R4729 T6335 T6333 parataxis SE,ratios
R4730 T6336 T6335 nmod mean,SE
R4731 T6337 T6335 punct ±,SE
R4732 T6338 T6335 punct ),SE
R4733 T6339 T6333 prep for,ratios
R4734 T6340 T6341 nmod B6,strains
R4735 T6341 T6339 pobj strains,for
R4736 T6342 T6340 punct ", ",B6
R4737 T6343 T6340 conj D2,B6
R4738 T6344 T6343 cc and,D2
R4739 T6345 T6343 conj BXD,D2
R4740 T6346 T6333 punct .,ratios
R4741 T6348 T6349 punct (,A
R4742 T6349 T6350 meta A,ratios
R4743 T6351 T6349 punct ),A
R4744 T6352 T6350 compound Mean,ratios
R4745 T6353 T6350 compound lick,ratios
R4746 T6354 T6350 prep for,ratios
R4747 T6355 T6356 nmod B6,mice
R4748 T6356 T6354 pobj mice,for
R4749 T6357 T6358 punct (,circles
R4750 T6358 T6355 parataxis circles,B6
R4751 T6359 T6358 amod filled,circles
R4752 T6360 T6358 punct ),circles
R4753 T6361 T6355 cc and,B6
R4754 T6362 T6355 conj D2,B6
R4755 T6363 T6364 punct (,circles
R4756 T6364 T6362 parataxis circles,D2
R4757 T6365 T6364 amod open,circles
R4758 T6366 T6364 punct ),circles
R4759 T6367 T6350 prep at,ratios
R4760 T6368 T6369 nummod two,concentrations
R4761 T6369 T6367 pobj concentrations,at
R4762 T6370 T6369 prep of,concentrations
R4763 T6371 T6370 pobj QHCl,of
R4764 T6372 T6371 cc and,QHCl
R4765 T6373 T6371 conj DB,QHCl
R4766 T6374 T6350 punct .,ratios
R4767 T6376 T6377 prep In,indicates
R4768 T6378 T6379 det all,panels
R4769 T6379 T6376 pobj panels,In
R4770 T6380 T6377 punct ", ",indicates
R4771 T6381 T6382 det a,ratio
R4772 T6382 T6377 nsubj ratio,indicates
R4773 T6383 T6382 amod lower,ratio
R4774 T6384 T6382 compound mean,ratio
R4775 T6385 T6382 compound lick,ratio
R4776 T6386 T6387 det a,aversion
R4777 T6387 T6377 dobj aversion,indicates
R4778 T6388 T6387 amod greater,aversion
R4779 T6389 T6387 punct ", ",aversion
R4780 T6390 T6387 cc and,aversion
R4781 T6391 T6392 advmod therefore,sensitivity
R4782 T6392 T6387 conj sensitivity,aversion
R4783 T6393 T6392 amod greater,sensitivity
R4784 T6394 T6392 compound taste,sensitivity
R4785 T6395 T6387 punct ", ",aversion
R4786 T6396 T6387 prep to,aversion
R4787 T6397 T6398 det the,stimulus
R4788 T6398 T6396 pobj stimulus,to
R4789 T6399 T6377 punct .,indicates
R4790 T6401 T6402 prep For,represented
R4791 T6403 T6404 compound panels,B
R4792 T6404 T6401 pobj B,For
R4793 T6405 T6404 punct ", ",B
R4794 T6406 T6404 conj C,B
R4795 T6407 T6406 punct ", ",C
R4796 T6408 T6406 cc and,C
R4797 T6409 T6406 conj D,C
R4798 T6410 T6402 punct ", ",represented
R4799 T6411 T6412 det each,strain
R4800 T6412 T6402 nsubjpass strain,represented
R4801 T6413 T6412 compound BXD,strain
R4802 T6414 T6402 auxpass is,represented
R4803 T6415 T6402 agent by,represented
R4804 T6416 T6417 det a,color
R4805 T6417 T6415 pobj color,by
R4806 T6418 T6417 amod different,color
R4807 T6419 T6402 punct ", ",represented
R4808 T6420 T6402 cc and,represented
R4809 T6421 T6402 conj listed,represented
R4810 T6422 T6421 prep in,listed
R4811 T6423 T6422 pobj order,in
R4812 T6424 T6421 prep from,listed
R4813 T6425 T6426 amod least,sensitive
R4814 T6426 T6424 amod sensitive,from
R4815 T6427 T6424 prep to,from
R4816 T6428 T6429 advmod most,sensitive
R4817 T6429 T6427 amod sensitive,to
R4818 T6430 T6424 prep to,from
R4819 T6431 T6432 nummod 1,mM
R4820 T6432 T6433 compound mM,QHCL
R4821 T6433 T6430 pobj QHCL,to
R4822 T6434 T6402 punct .,represented
R4823 T6436 T6437 punct (,B
R4824 T6437 T6438 meta B,ratios
R4825 T6439 T6437 punct ),B
R4826 T6440 T6438 compound Mean,ratios
R4827 T6441 T6438 compound lick,ratios
R4828 T6442 T6438 prep for,ratios
R4829 T6443 T6444 det the,strains
R4830 T6444 T6442 pobj strains,for
R4831 T6445 T6444 nummod six,strains
R4832 T6446 T6444 compound BXD,strains
R4833 T6447 T6448 dep that,are
R4834 T6448 T6444 relcl are,strains
R4835 T6449 T6450 advmod most,sensitive
R4836 T6450 T6448 acomp sensitive,are
R4837 T6451 T6450 prep to,sensitive
R4838 T6452 T6451 pobj QHCl,to
R4839 T6453 T6448 prep in,are
R4840 T6454 T6455 det this,assay
R4841 T6455 T6453 pobj assay,in
R4842 T6456 T6438 punct .,ratios
R4843 T6458 T6459 punct (,C
R4844 T6459 T6460 meta C,ratios
R4845 T6461 T6459 punct ),C
R4846 T6462 T6460 compound Mean,ratios
R4847 T6463 T6460 compound lick,ratios
R4848 T6464 T6460 prep for,ratios
R4849 T6465 T6466 det the,strains
R4850 T6466 T6464 pobj strains,for
R4851 T6467 T6466 nummod five,strains
R4852 T6468 T6466 compound BXD,strains
R4853 T6469 T6470 dep that,are
R4854 T6470 T6466 relcl are,strains
R4855 T6471 T6472 advmod least,sensitive
R4856 T6472 T6470 acomp sensitive,are
R4857 T6473 T6472 prep to,sensitive
R4858 T6474 T6473 pobj QHCl,to
R4859 T6475 T6470 prep in,are
R4860 T6476 T6477 det this,assay
R4861 T6477 T6475 pobj assay,in
R4862 T6478 T6460 punct .,ratios
R4863 T6480 T6481 punct (,D
R4864 T6481 T6482 meta D,ratios
R4865 T6483 T6481 punct ),D
R4866 T6484 T6482 compound Mean,ratios
R4867 T6485 T6482 compound lick,ratios
R4868 T6486 T6482 prep for,ratios
R4869 T6487 T6488 det the,strains
R4870 T6488 T6486 pobj strains,for
R4871 T6489 T6488 nummod six,strains
R4872 T6490 T6488 compound BXD,strains
R4873 T6491 T6488 amod intermediate,strains
R4874 T6492 T6491 prep in,intermediate
R4875 T6493 T6494 compound QHCl,sensitivity
R4876 T6494 T6492 pobj sensitivity,in
R4877 T6495 T6494 compound taste,sensitivity
R4878 T6496 T6494 prep to,sensitivity
R4879 T6497 T6496 pobj those,to
R4880 T6498 T6497 prep in,those
R4881 T6499 T6500 punct (,B
R4882 T6500 T6498 pobj B,in
R4883 T6501 T6500 punct ),B
R4884 T6502 T6500 cc and,B
R4885 T6503 T6504 punct (,C
R4886 T6504 T6500 conj C,B
R4887 T6505 T6482 punct ),ratios
R4888 T6506 T6482 punct .,ratios
R4889 T6508 T6509 nsubjpass Cutoffs,set
R4890 T6509 T6518 ccomp set,exhibited
R4891 T6510 T6508 prep for,Cutoffs
R4892 T6511 T6512 det the,groups
R4893 T6512 T6510 pobj groups,for
R4894 T6513 T6512 nummod three,groups
R4895 T6514 T6512 compound QHCl,groups
R4896 T6515 T6512 compound taster,groups
R4897 T6516 T6509 auxpass were,set
R4898 T6517 T6509 advmod arbitrarily,set
R4899 T6519 T6509 punct ", ",set
R4900 T6520 T6521 mark as,was
R4901 T6521 T6509 advcl was,set
R4902 T6522 T6521 expl there,was
R4903 T6523 T6524 det a,continuity
R4904 T6524 T6521 attr continuity,was
R4905 T6525 T6524 prep of,continuity
R4906 T6526 T6527 det the,phenotype
R4907 T6527 T6525 pobj phenotype,of
R4908 T6528 T6524 prep at,continuity
R4909 T6529 T6530 nummod 1,mM
R4910 T6530 T6531 compound mM,QHCl
R4911 T6531 T6528 pobj QHCl,at
R4912 T6532 T6518 punct : ,exhibited
R4913 T6533 T6534 amod sensitive,strains
R4914 T6534 T6518 nsubj strains,exhibited
R4915 T6535 T6536 det a,ratio
R4916 T6536 T6518 dobj ratio,exhibited
R4917 T6537 T6536 compound lick,ratio
R4918 T6538 T6536 prep for,ratio
R4919 T6539 T6540 nummod 1,mM
R4920 T6540 T6541 compound mM,QHCl
R4921 T6541 T6538 pobj QHCl,for
R4922 T6542 T6536 prep of,ratio
R4923 T6543 T6544 punct ≤,0.3
R4924 T6544 T6542 pobj 0.3,of
R4925 T6545 T6518 punct ", ",exhibited
R4926 T6546 T6547 amod intermediate,strains
R4927 T6547 T6548 nsubj strains,0.6
R4928 T6548 T6518 conj 0.6,exhibited
R4929 T6549 T6548 quantmod from,0.6
R4930 T6550 T6548 quantmod 0.31,0.6
R4931 T6551 T6548 punct -,0.6
R4932 T6552 T6548 punct ", ",0.6
R4933 T6553 T6548 cc and,0.6
R4934 T6554 T6555 amod insensitive,strains
R4935 T6555 T6556 nsubj strains,0.6
R4936 T6556 T6548 conj 0.6,0.6
R4937 T6557 T6556 punct >,0.6
R4938 T6558 T6518 punct .,exhibited
R4939 T6560 T6561 det The,absence
R4940 T6561 T6562 nsubj absence,suggests
R4941 T6563 T6561 prep of,absence
R4942 T6564 T6565 nummod two,classes
R4943 T6565 T6563 pobj classes,of
R4944 T6566 T6565 amod distinct,classes
R4945 T6567 T6565 amod phenotypic,classes
R4946 T6568 T6569 mark that,is
R4947 T6569 T6562 ccomp is,suggests
R4948 T6570 T6569 nsubj sensitivity,is
R4949 T6571 T6570 prep to,sensitivity
R4950 T6572 T6571 pobj QHCL,to
R4951 T6573 T6569 prep under,is
R4952 T6574 T6575 amod polygenic,control
R4953 T6575 T6573 pobj control,under
R4954 T6576 T6562 punct .,suggests
R1238 T1698 T1696 attr difference,was
R1240 T1700 T1698 compound strain,difference
R1241 T1701 T1696 prep for,was
R1242 T1702 T1703 det both,QHCl
R1243 T1703 T1701 pobj QHCl,for
R1244 T1704 T1705 nummod 1,mM
R1245 T1705 T1703 compound mM,QHCl
R1246 T1706 T1704 cc and,1
R1247 T1707 T1704 conj 3,1
R1248 T1708 T1709 punct (,0.0001
R1249 T1709 T1703 parataxis 0.0001,QHCl
R1250 T1710 T1711 nmod F,25
R1251 T1711 T1715 nsubj 25,24.6
R1252 T1712 T1711 punct [,25
R1253 T1713 T1711 nummod 1,25
R1254 T1714 T1711 punct ",",25
R1255 T1715 T1709 ccomp 24.6,0.0001
R1256 T1716 T1711 punct ],25
R1302 T1769 T1770 nsubj We,tested
R1303 T1771 T1770 advmod next,tested
R1304 T1772 T1770 dobj mice,tested
R1305 T1773 T1772 prep from,mice
R1306 T1774 T1775 nummod 17,lines
R1307 T1775 T1773 pobj lines,from
R1308 T1776 T1775 compound BXD,lines
R1309 T1777 T1770 prep in,tested
R1310 T1778 T1779 det the,manner
R1311 T1779 T1777 pobj manner,in
R1312 T1780 T1779 amod same,manner
R1313 T1781 T1770 punct .,tested
R1314 T1783 T1784 compound BXD,mice
R1315 T1784 T1785 nsubj mice,avoided
R1316 T1786 T1785 advmod also,avoided
R1317 T1787 T1785 advmod typically,avoided
R1318 T1788 T1789 det both,stimuli
R1319 T1789 T1785 dobj stimuli,avoided
R1320 T1790 T1785 prep in,avoided
R1321 T1791 T1792 det a,manner
R1322 T1792 T1790 pobj manner,in
R1323 T1793 T1794 npadvmod concentration,dependent
R1324 T1794 T1792 amod dependent,manner
R1325 T1795 T1796 punct (,Table
R1326 T1796 T1785 parataxis Table,avoided
R1327 T1797 T1798 nmod Figures,1B
R1328 T1798 T1796 dep 1B,Table
R1329 T1799 T1800 punct –,1D
R1330 T1800 T1798 prep 1D,1B
R1331 T1801 T1796 punct ;,Table
R1332 T1802 T1796 nummod 1,Table
R4 T131 T130 compound Tas2r,locus
R21 T153 T152 punct -,tasting
R26 T158 T157 amod gustatory,system
R49 T183 T182 compound taste,receptors
R56 T190 T189 auxpass are,expressed
R62 T196 T195 compound receptor,cells
R76 T212 T213 npadvmod receptor,dependent
R79 T215 T213 cc and,dependent
R80 T216 T217 punct -,independent
R81 T217 T213 conj independent,dependent
R82 T218 T211 compound transduction,mechanisms
R106 T246 T245 punct -,access
R108 T248 T247 amod behavioral,testing
R109 T249 T247 compound taste,testing
R113 T253 T252 punct /,Ty
R115 T255 T256 amod recombinant,inbred
R116 T256 T254 amod inbred,strains
R117 T257 T258 punct (,RI
R118 T258 T256 parataxis RI,inbred
R119 T259 T258 punct ),RI
R120 T260 T254 compound mouse,strains
R125 T265 T264 amod major,locus
R126 T266 T264 amod quantitative,locus
R127 T267 T264 compound trait,locus
R143 T285 T286 punct ~,5
R144 T286 T287 nummod 5,Mb
R145 T287 T284 compound Mb,interval
R161 T304 T302 prep at,Tas2rs
R162 T305 T306 det this,locus
R163 T306 T304 pobj locus,at
R168 T312 T311 nmod coding,polymorphisms
R169 T313 T311 nmod region,polymorphisms
R170 T314 T311 amod single,polymorphisms
R171 T315 T311 compound nucleotide,polymorphisms
R178 T322 T321 nummod two,strains
R179 T323 T324 nmod BXD,Ty
R182 T326 T321 amod RI,strains
R183 T327 T321 amod parental,strains
R187 T331 T330 punct /,6J
R190 T334 T333 npadvmod quinine,sensitive
R191 T335 T333 punct -,sensitive
R196 T340 T339 punct /,2J
R199 T343 T342 npadvmod quinine,insensitive
R212 T357 T356 amod RI,lines
R216 T362 T361 nmod C57BL,6J
R217 T363 T361 punct /,6J
R219 T365 T361 cc or,6J
R220 T366 T367 compound DBA,2J
R223 T369 T364 compound Tas2r,alleles
R232 T378 T376 acl containing,lines
R233 T379 T380 compound C57BL,6J
R248 T394 T393 punct /,2J
R255 T403 T402 amod entire,cluster
R256 T404 T402 compound Tas2r,cluster
R259 T407 T406 amod large,haplotype
R275 T427 T428 npadvmod taste,salient
R282 T434 T433 amod major,QTL
R289 T441 T442 det a,cascade
R292 T444 T442 amod dependent,cascade
R311 T465 T464 amod large,number
R320 T474 T473 compound Tas2r,cluster
R327 T481 T482 amod inbred,strains
R328 T482 T480 nsubj strains,exhibit
R332 T486 T487 amod bitter,taste
R333 T487 T485 compound taste,phenotypes
R337 T491 T492 compound T2R,receptors
R338 T492 T490 nsubj receptors,are
R1509 T2091 T2089 punct ),Figure
R1510 T2092 T2034 punct .,were
R1511 T2100 T2099 nummod 6,hromosome
R1512 T2112 T2111 prep to,ked
R2249 T3108 T3117 advcl found,are
R2254 T3113 T3111 pobj Tas2rs,between
R2257 T3116 T3108 auxpass are,found
R2258 T3118 T3108 prep in,found
R2259 T3119 T3120 det all,regions
R2260 T3120 T3118 pobj regions,in
R2261 T3121 T3120 prep of,regions
R2262 T3122 T3123 det the,receptors
R2263 T3123 T3121 pobj receptors,of
R2264 T3124 T3117 punct ", ",are
R2265 T3125 T3126 nummod 23,%
R2266 T3126 T3117 nsubj %,are
R2267 T3127 T3126 prep of,%
R2268 T3128 T3129 det the,changes
R2269 T3129 T3127 pobj changes,of
R2270 T3130 T3131 compound amino,acid
R2271 T3131 T3129 compound acid,changes
R2272 T3132 T3129 acl seen,changes
R2273 T3133 T3117 prep within,are
R2274 T3134 T3135 det the,loops
R2275 T3135 T3133 pobj loops,within
R2276 T3136 T3135 amod first,loops
R2277 T3137 T3135 nummod two,loops
R2278 T3138 T3135 amod extracellular,loops
R2279 T3139 T3135 prep of,loops
R2280 T3140 T3141 det the,T2Rs
R2281 T3141 T3139 pobj T2Rs,of
R2282 T3142 T3143 punct (,shown
R2283 T3143 T3117 parataxis shown,are
R2284 T3144 T3143 nsubj data,shown
R2285 T3145 T3143 neg not,shown
R2286 T3146 T3143 punct ),shown
R2287 T3147 T3117 punct .,are
R2288 T3154 T3155 nsubj variability,suggested
R2289 T3156 T3154 prep between,variability
R2290 T3157 T3158 amod orthologous,receptors
R2291 T3158 T3156 pobj receptors,between
R2292 T3159 T3154 prep in,variability
R2293 T3160 T3161 det these,strains
R2294 T3161 T3159 pobj strains,in
R2295 T3162 T3161 nummod two,strains
R2296 T3163 T3161 amod inbred,strains
R2297 T3164 T3165 mark that,be
R2298 T3165 T3155 ccomp be,suggested
R2299 T3166 T3165 nsubj it,be
R2300 T3167 T3165 aux might,be
R2301 T3168 T3165 acomp possible,be
R2302 T3169 T3170 aux to,narrow
R2303 T3170 T3165 xcomp narrow,be
R2304 T3171 T3172 det the,boundaries
R2305 T3172 T3170 dobj boundaries,narrow
R2306 T3173 T3172 amod physical,boundaries
R2307 T3174 T3172 prep of,boundaries
R2308 T3175 T3176 det the,QTL
R2309 T3176 T3174 pobj QTL,of
R2310 T3177 T3178 compound QHCl,taste
R2311 T3178 T3176 compound taste,QTL
R2312 T3179 T3170 prep by,narrow
R2313 T3180 T3179 pcomp determining,by
R2314 T3181 T3182 det which,alleles
R2315 T3182 T3184 dep alleles,correlated
R2316 T3183 T3182 compound Tas2r,alleles
R2317 T3184 T3180 ccomp correlated,determining
R2318 T3185 T3184 auxpass are,correlated
R2319 T3186 T3184 prep with,correlated
R2320 T3187 T3188 compound QHCl,taste
R2321 T3188 T3189 compound taste,sensitivity
R2322 T3189 T3186 pobj sensitivity,with
R2323 T3190 T3155 punct .,suggested
R2324 T3192 T3193 advmod Therefore,proceeded
R2325 T3194 T3193 punct ", ",proceeded
R3542 T4817 T4818 nsubj Characterization,shed
R3543 T4819 T4817 prep of,Characterization
R3544 T4820 T4821 compound Tas2r,sequences
R3545 T4821 T4819 pobj sequences,of
R3546 T4822 T4821 prep of,sequences
R3547 T4823 T4824 amod several,mouse
R3548 T4824 T4822 pobj mouse,of
R3549 T4825 T4824 amod wild,mouse
R3550 T4826 T4824 appos species,mouse
R3551 T4827 T4826 cc or,species
R3552 T4828 T4826 conj subspecies,species
R3553 T4829 T4822 punct ", ",of
R3554 T4830 T4822 cc or,of
R3555 T4831 T4822 conj in,of
R3556 T4832 T4833 amod other,lines
R3557 T4833 T4831 pobj lines,in
R3558 T4834 T4833 amod inbred,lines
R3559 T4835 T4818 punct ", ",shed
R3560 T4836 T4818 aux would,shed
R3561 T4837 T4818 dobj light,shed
R3562 T4838 T4818 prep on,shed
R3563 T4839 T4840 det this,issue
R3564 T4840 T4838 pobj issue,on
R3565 T4841 T4818 punct .,shed

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3545 19218-19226 GO_EXT:0015267 denotes channels
T7206 18933-18942 SO_EXT:0001024 denotes haplotype
T7205 18927-18932 PR_EXT:000036337 denotes Tas2r
T7204 18831-18840 SO_EXT:0001024 denotes haplotype
T7203 18825-18830 PR_EXT:000036337 denotes Tas2r
T7202 18777-18782 GO:0050909 denotes taste
T7201 18731-18735 NCBITaxon:10088 denotes mice
T7200 18647-18651 NCBITaxon:10088 denotes mice
T7199 18626-18635 SO_EXT:0001024 denotes haplotype
T7198 18605-18614 SO_EXT:0001024 denotes haplotype
T7197 18591-18600 SO_EXT:0001024 denotes haplotype
T7196 18585-18590 PR_EXT:000036337 denotes Tas2r
T7195 18483-18488 GO:0050909 denotes taste
T7194 18453-18461 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T7193 18447-18452 PR_EXT:000036337 denotes Tas2r
T7094 18384-18396 GO_PATO_EXT:biological_behavior denotes behaviorally
T7093 18338-18344 SO_EXT:0001023 denotes allele
T7092 18320-18326 SO_EXT:0001023 denotes allele
T7091 18237-18242 PR_EXT:000036337 denotes Tas2r
T7090 18201-18204 CHEBI_SO_EXT:DNA denotes DNA
T7089 18193-18204 SO_EXT:genomic_DNA denotes genomic DNA
T7088 18158-18168 GO_SO_EXT:chromosome denotes chromosome
T7087 18137-18143 PR_EXT:000036337 denotes Tas2rs
T7086 18111-18122 SO_EXT:0000195 denotes coding exon
T7085 18101-18105 NCBITaxon:10088 denotes mice
T7084 18078-18087 SO_EXT:0001024 denotes haplotype
T7083 18052-18057 PR_EXT:000036337 denotes Tas2r
T6865 13854-13860 SO_EXT:0001026 denotes genome
T6864 13835-13843 SO_EXT:sequence_assembly_entity_or_process denotes assembly
T6863 13808-13817 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes positions
T6862 13795-13805 _FRAGMENT denotes chromosome
T6861 13782-13783 CHEBI_SO_EXT:base denotes b
T6860 13751-13755 PR_EXT:000013555 denotes Prh1
T6859 13742-13746 PR_EXT:000013555 denotes Prp2
T6858 13732-13740 CHEBI_PR_EXT:protein denotes proteins
T6857 13723-13731 UBERON:0001836 denotes salivary
T6856 13710-13717 CHEBI_SO_EXT:proline denotes proline
T6855 13701-13709 SO_EXT:sequence_coding_function denotes encoding
T6854 13695-13700 SO_EXT:0000704 denotes genes
T6853 13666-13672 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T6852 13654-13665 SO_EXT:polymorphism denotes polymorphic
T6851 13596-13602 PR_EXT:000036337 denotes Tas2rs
T6850 13570-13580 GO_SO_EXT:chromosome denotes chromosome
T6849 13550-13555 SO_EXT:0000704 denotes genes
T6848 13544-13549 PR_EXT:000036337 denotes Tas2r
T6847 13510-13515 PR_EXT:000036337 denotes Tas2r
T6846 13497-13507 GO_SO_EXT:chromosome denotes chromosome
T6699 13407-13413 SO_EXT:0001026 denotes genome
T6698 13401-13406 NCBITaxon:10088 denotes mouse
T6697 13351-13352 CHEBI_SO_EXT:base denotes b
T6696 13329-13336 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T6695 13317-13328 SO_EXT:polymorphism denotes polymorphic
T6694 13272-13278 PR_EXT:000036337 denotes Tas2rs
T6693 13239-13260 GO_EXT:0033038 denotes bitter taste receptor
T6692 13239-13251 GO:0050913 denotes bitter taste
T6691 13177-13184 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T6690 13144-13147 SO_EXT:0000771 denotes QTL
T6689 13105-13111 SO_EXT:0001026 denotes genome
T6688 13056-13062 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T6687 13044-13055 SO_EXT:polymorphism denotes polymorphic
T6686 12936-12946 GO_SO_EXT:chromosome denotes chromosome
T6685 12885-12895 GO_SO_EXT:chromosome denotes chromosome
T6684 12875-12881 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T6683 12849-12852 SO_EXT:0000771 denotes QTL
T6596 10929-10935 SO_EXT:0001026 denotes genome
T6595 10873-10876 SO_EXT:0000771 denotes QTL
T6594 10814-10823 GO_EXT:reaction_or_response denotes responses
T6593 10808-10813 GO:0050909 denotes taste
T6592 10776-10786 GO_SO_EXT:chromosome denotes chromosome
T6591 10769-10772 SO_EXT:0000771 denotes QTL
T6590 10731-10741 GO_SO_EXT:chromosome denotes chromosome
T6589 10724-10727 SO_EXT:0000771 denotes QTL
T6588 10647-10657 GO_SO_EXT:chromosome denotes chromosome
T6587 10641-10646 NCBITaxon:10088 denotes mouse
T6977 16651-16667 CHEBI_SO_EXT:oligonucleotide denotes oligonucleotides
T6976 16639-16646 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T6975 16627-16646 GO_EXT:0015666 denotes restriction enzymes
T6974 16573-16579 GO_EXT:taster denotes taster
T6973 16546-16552 GO_EXT:taster denotes taster
T6972 16518-16524 GO_EXT:taster denotes taster
T6971 16477-16485 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T6970 16471-16476 PR_EXT:000036337 denotes Tas2r
T6969 16422-16430 PR_EXT:000016902 denotes Tas2r120
T6968 16409-16420 SO_EXT:0000006 denotes PCR product
T6967 16351-16359 PR_EXT:000016899 denotes Tas2r116
T6966 16341-16349 PR_EXT:000016892 denotes Tas2r105
T6965 16327-16339 SO_EXT:0000006 denotes PCR products
T6964 16245-16251 PR_EXT:000036337 denotes Tas2rs
T6963 16229-16236 SO_EXT:0001023 denotes alleles
T6962 16211-16217 PR_EXT:000036337 denotes Tas2rs
T6961 16177-16186 SO_EXT:sequence_variation_entity_or_quality denotes variation
T6960 16169-16176 SO_EXT:0001023 denotes Allelic
T6586 10632-10637 GO:0050909 denotes taste
T6585 10619-10622 SO_EXT:0000771 denotes QTL
T6331 9623-9630 GO:0065007 denotes control
T6330 9617-9622 SO_EXT:0000704 denotes genic
T6329 9298-9304 GO_EXT:taster denotes taster
T6328 9228-9233 GO:0050909 denotes taste
T6327 8790-8795 GO:0050909 denotes taste
T6326 8656-8660 NCBITaxon:10088 denotes mice
T6122 31069-31075 SO_EXT:0001023 denotes allele
T6121 31021-31032 SO_EXT:0000006 denotes PCR product
T6120 30994-31002 PR_EXT:000016902 denotes Tas2r120
T6119 30960-30963 CHEBI_SO_EXT:DNA denotes DNA
T6118 30952-30963 SO_EXT:genomic_DNA denotes genomic DNA
T6117 30931-30936 SO_EXT:cDNA denotes cDNAs
T6116 30925-30930 PR_EXT:000036337 denotes Tas2r
T6115 30864-30889 GO_EXT:0015666 denotes restriction endonucleases
T6114 30833-30840 SO_EXT:0001023 denotes alleles
T6113 30769-30786 SO_EXT:0000061 denotes restriction sites
T6112 30721-30734 SO_EXT:polymorphism denotes polymorphisms
T6111 30661-30670 SO_EXT:biological_sequence denotes sequences
T6110 30616-30625 SO_EXT:biological_sequence denotes sequences
T6109 30595-30605 CHEBI:33694 denotes Biopolymer
T6108 30465-30477 SO_EXT:0000006 denotes PCR products
T6107 30393-30403 GO_EXT:polymerase denotes polymerase
T6106 30339-30349 GO_EXT:polymerase denotes polymerase
T6105 30293-30296 CHEBI_SO_EXT:DNA denotes DNA
T6104 30285-30296 SO_EXT:genomic_DNA denotes genomic DNA
T6103 30247-30252 PR_EXT:000036337 denotes Tas2r
T6102 30242-30246 SO_EXT:0000147 denotes exon
T6101 30218-30226 SO_EXT:biological_sequence denotes sequence
T6100 30209-30217 SO:0000357 denotes flanking
T6099 30204-30205 CHEBI_SO_EXT:base denotes b
T6098 30179-30193 SO_EXT:coding_sequence denotes coding regions
T6097 30164-30170 SO_EXT:0001026 denotes genome
T6096 30134-30143 SO_EXT:biological_sequence denotes sequences
T6095 30129-30133 SO_EXT:cDNA denotes cDNA
T6094 30067-30083 CHEBI_SO_EXT:oligonucleotide denotes Oligonucleotides
T6093 30059-30066 SO_EXT:0001023 denotes alleles
T6092 30055-30058 PR_EXT:000036337 denotes T2R
T5392 29053-29057 NCBITaxon:10088 denotes mice
T5391 29010-29019 GO:0007608 denotes olfactory
T5390 28989-28994 GO:0050909 denotes taste
T5389 28967-28972 CHEBI:15377 denotes water
T5388 28929-28933 NCBITaxon:10088 denotes mice
T5387 28883-28888 CHEBI:15377 denotes water
T5386 28796-28801 CHEBI:15377 denotes water
T5385 28772-28779 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T5384 28681-28688 NCBITaxon:33208 denotes animals
T5383 28658-28663 CHEBI:15377 denotes water
T5382 28617-28625 CHEBI:36357 denotes compound
T5381 28526-28533 CHEBI:17992 denotes sucrose
T5380 28518-28522 NCBITaxon:10088 denotes mice
T5379 28376-28380 NCBITaxon:10088 denotes mice
T5378 28269-28274 CHEBI:15377 denotes water
T5377 28243-28248 CHEBI:15377 denotes water
T5376 28156-28161 CHEBI:15377 denotes water
T5375 28065-28070 NCBITaxon:10088 denotes mouse
T5374 27977-27981 NCBITaxon:10088 denotes mice
T5373 27943-27948 CHEBI:15377 denotes water
T5372 27733-27740 CHEBI:17992 denotes sucrose
T5371 27689-27693 CHEBI:8502 denotes PROP
T5370 27630-27635 GO:0050909 denotes taste
T5369 27571-27575 NCBITaxon:10088 denotes Mice
T5368 27416-27420 NCBITaxon:10088 denotes mice
T5367 27341-27346 NCBITaxon:10088 denotes mouse
T5366 27245-27250 CHEBI:15377 denotes water
T5365 27137-27141 NCBITaxon:10088 denotes mice
T5364 27097-27102 CHEBI:15377 denotes water
T5363 27004-27008 NCBITaxon:10088 denotes mice
T5362 26979-26984 CHEBI:15377 denotes water
T5361 26755-26765 GO_PATO_EXT:biological_behavior denotes behavioral
T5901 29931-29941 GO_SO_EXT:chromosome denotes chromosome
T5900 29924-29927 SO_EXT:0000771 denotes QTL
T5899 29897-29904 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T5898 29768-29774 SO_EXT:0001026 denotes genome
T5897 29593-29599 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T5896 29530-29533 SO_EXT:0000771 denotes QTL
T5895 29504-29528 SO_EXT:0000771 denotes quantitative trait locus
T5894 29477-29485 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T5893 29256-29264 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T5892 29187-29191 NCBITaxon:10088 denotes mice
T5891 29137-29140 SO_EXT:0000771 denotes QTL
T5092 26700-26706 NCBITaxon:33208 denotes Animal
T5091 26642-26648 NCBITaxon:33208 denotes animal
T5090 26588-26593 GO:0050909 denotes taste
T5089 26573-26578 CHEBI:15377 denotes water
T5088 26526-26534 CHEBI:75958 denotes solution
T5087 26451-26464 CHEBI:17883 denotes hydrochloride
T5086 26443-26450 CHEBI:15854 denotes quinine
T5085 26418-26438 CHEBI:8502 denotes 6-n-propylthiouracil
T5084 26408-26416 CHEBI:16150 denotes benzoate
T5083 26388-26395 CHEBI:17992 denotes Sucrose
T5082 26377-26386 CHEBI_EXT:chemical_substance_or_polyatomic_entity denotes chemicals
T5081 26363-26370 CHEBI_EXT:33893 denotes reagent
T5080 26310-26315 GO:0050909 denotes Taste
T5079 26296-26302 NCBITaxon:9989 denotes rodent
T5078 26278-26282 CHEBI_EXT:33290 denotes food
T5077 26185-26189 NCBITaxon:10088 denotes mice
T5076 26142-26148 GO:0007618 denotes mating
T5075 26132-26136 GO_EXT:breeding denotes bred
T5074 26054-26058 NCBITaxon:10088 denotes mice
T5073 25954-25961 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T5072 25944-25949 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T5071 25915-25919 NCBITaxon:10088 denotes mice
T5070 25896-25907 GO_SO_EXT:sequence_rearrangement_process denotes recombinant
T5069 25874-25879 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T5068 25863-25870 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T5067 25840-25847 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T5066 25831-25836 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T5065 25770-25782 GO_PATO_EXT:biological_behavior denotes behaviorally
T5064 25760-25764 NCBITaxon:10088 denotes mice
T5063 25753-25759 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T5062 25744-25748 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T5061 25738-25743 UBERON:0007023 denotes adult
T5060 25713-25722 CHEBI:75958 denotes solutions
T5059 25704-25708 NCBITaxon:10088 denotes Mice
T4894 25640-25647 GO_EXT:reaction_or_response denotes respond
T4893 25631-25636 CL_GO_EXT:cell denotes cells
T4892 25625-25636 CL:0000209 denotes taste cells
T4891 25625-25630 GO:0050909 denotes taste
T4890 25596-25606 GO:0010467 denotes expressing
T4889 25592-25595 PR_EXT:000036337 denotes T2R
T4888 25530-25539 SO_EXT:sequence_variation_entity_or_quality denotes variation
T4887 25521-25529 SO_EXT:biological_sequence denotes sequence
T4886 25493-25502 GO_EXT:0004872 denotes receptors
T4885 25470-25474 PR_EXT:000036337 denotes T2Rs
T4884 25442-25447 NCBITaxon:10088 denotes mouse
T4883 25415-25423 SO_EXT:biological_sequence denotes sequence
T4882 25407-25414 CHEBI_PR_EXT:protein denotes protein
T4881 25403-25406 PR_EXT:000036337 denotes T2R
T4880 25356-25361 GO:0050909 denotes taste
T4879 25348-25355 CHEBI:15854 denotes quinine
T4878 25317-25326 SO_EXT:0001024 denotes haplotype
T4877 25279-25283 NCBITaxon:10088 denotes mice
T4876 25242-25253 SO_EXT:polymorphism denotes polymorphic
T4875 25217-25227 GO_SO_EXT:chromosome denotes chromosome
T4874 25197-25202 SO_EXT:0000704 denotes genes
T4873 25191-25196 PR_EXT:000036337 denotes Tas2r
T4872 25175-25184 GO_EXT:0004872 denotes receptors
T4871 25171-25174 PR_EXT:000036337 denotes T2R
T4870 25117-25122 GO:0050909 denotes taste
T4869 25109-25116 CHEBI:15854 denotes quinine
T4868 25070-25074 NCBITaxon:10088 denotes mice
T4867 25055-25060 SO_EXT:0000704 denotes genic
T4866 25012-25017 GO:0050909 denotes taste
T4865 24987-24994 CHEBI:15854 denotes quinine
T4864 24977-24986 CHEBI_EXT:chemical_substance_or_polyatomic_entity denotes substance
T4863 24962-24976 GO:0050913 denotes bitter-tasting
T3738 24816-24823 NCBITaxon:species denotes species
T3737 24810-24815 NCBITaxon:10088 denotes mouse
T3736 24805-24809 SO_EXT:wild_type_entity_or_quality denotes wild
T3735 24784-24793 SO_EXT:biological_sequence denotes sequences
T3734 24778-24783 PR_EXT:000036337 denotes Tas2r
T3733 24719-24724 NCBITaxon:10088 denotes mouse
T3732 24714-24718 SO_EXT:wild_type_entity_or_quality denotes wild
T3731 24692-24702 SO_EXT:0001024 denotes haplotypes
T3730 24686-24691 PR_EXT:000036337 denotes Tas2r
T3729 24605-24609 NCBITaxon:10088 denotes mice
T3728 24507-24514 NCBITaxon:species denotes species
T3727 24472-24477 NCBITaxon:10088 denotes mouse
T3726 24374-24380 PR_EXT:000036337 denotes Tas2rs
T3725 24343-24360 NCBITaxon:9527 denotes old world monkeys
T3724 24328-24338 NCBITaxon:9604 denotes great apes
T3723 24320-24326 NCBITaxon:9606 denotes humans
T3722 24310-24316 PR_EXT:000036337 denotes Tas2rs
T3721 24288-24296 SO_EXT:biological_sequence denotes sequence
T3720 24227-24238 SO_EXT:0000855 denotes orthologues
T3719 24205-24218 SO_EXT:sequence_substitution_entity_or_process denotes substitutions
T3718 24191-24204 SO:0001816 denotes nonsynonymous
T3717 24149-24157 GO_EXT:0004872 denotes receptor
T3716 24128-24136 CHEBI_PR_EXT:protein denotes proteins
T3715 24095-24102 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T3714 24088-24094 CHEBI_GO_EXT:ligand denotes ligand
T3713 24069-24076 SO_EXT:sequence_alteration_entity_or_process denotes changes
T3712 23996-24004 SO_EXT:sequence_variant_entity denotes variants
T3711 23992-23995 PR_EXT:000036337 denotes T2R
T3710 23906-23910 PR_EXT:000036337 denotes T2Rs
T3709 23880-23888 GO_EXT:reaction_or_response denotes response
T3708 23873-23879 CHEBI_GO_EXT:ligand denotes ligand
T3707 23807-23816 GO_EXT:0004872 denotes receptors
T3706 23785-23793 CL_GO_EXT:cell denotes cellular
T3705 23780-23793 GO:0005576 denotes extracellular
T3704 23752-23758 PR_EXT:000036337 denotes Tas2rs
T3703 23736-23745 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T3702 23727-23735 SO_EXT:missense_quality_or_entity denotes missense
T3701 23683-23692 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3700 23665-23673 GO_EXT:0004872 denotes receptor
T3699 23642-23648 CHEBI_GO_EXT:ligand denotes ligand
T3698 23620-23627 SO_EXT:0000417 denotes domains
T3697 23545-23554 SO_EXT:sequence_variation_entity_or_quality denotes variation
T3696 23516-23522 PR_EXT:000036337 denotes Tas2rs
T3695 23448-23461 CHEBI:27641 denotes cyclohexamide
T3694 23424-23433 CHEBI:36357 denotes compounds
T3693 23404-23413 GO_EXT:reaction_or_response denotes responses
T3692 23398-23403 GO:0050909 denotes taste
T3691 23351-23355 NCBITaxon:10088 denotes mice
T3690 23329-23337 CHEBI_PR_EXT:protein denotes proteins
T3689 23321-23328 SO_EXT:sequence_variant_or_variation denotes variant
T3688 23314-23320 SO_EXT:sequence_coding_function denotes encode
T3687 23298-23304 PR_EXT:000036337 denotes Tas2rs
T3686 23211-23217 PR_EXT:000036337 denotes Tas2rs
T3685 23166-23176 GO_SO_EXT:chromosome denotes chromosome
T3684 23157-23162 GO:0050909 denotes taste
T3683 23149-23156 CHEBI:15854 denotes quinine
T3682 23141-23144 SO_EXT:0000771 denotes QTL
T3681 23094-23104 GO_SO_EXT:chromosome denotes chromosome
T3680 23057-23061 CHEBI:8502 denotes PROP
T3679 23049-23052 SO_EXT:0000771 denotes QTL
T3678 22993-22996 PR_EXT:000036337 denotes T2R
T3677 22956-22975 CHEBI_EXT:62488 denotes signaling molecules
T3676 22956-22965 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3675 22936-22944 SO_EXT:sequence_coding_function denotes encoding
T3674 22930-22935 SO_EXT:0000704 denotes genes
T3673 22876-22883 SO_EXT:0000704 denotes genetic
T3672 22865-22875 GO_PATO_EXT:biological_behavior denotes behavioral
T3671 22851-22863 GO:0050913 denotes bitter taste
T3670 22835-22845 SO_EXT:0000854 denotes paralogues
T3669 22797-22802 GO:0050909 denotes taste
T3668 22793-22796 CHEBI:46261 denotes PTC
T3667 22780-22789 CHEBI:32111 denotes saccharin
T3666 22764-22769 SO_EXT:0000704 denotes genes
T3665 22714-22720 NCBITaxon:9606 denotes humans
T3664 22693-22698 GO:0050909 denotes taste
T3663 22688-22691 CHEBI:46261 denotes PTC
T3662 22667-22686 CHEBI:46261 denotes phenylthiocarbamide
T3661 22617-22622 PR_EXT:000036337 denotes Tas2r
T3660 22568-22575 SO_EXT:sequence_cloning_process denotes cloning
T3659 22539-22550 GO:0050917 denotes umami taste
T3658 22545-22550 GO:0050916 denotes taste
T3657 22529-22534 _FRAGMENT denotes sweet
T3656 22506-22514 GO_EXT:0004872 denotes receptor
T3655 22496-22503 SO_EXT:sequence_coding_function denotes encodes
T3654 22486-22490 SO_EXT:0000704 denotes gene
T3653 22479-22485 PR_EXT:000016062 denotes Tas1r3
T3652 22451-22456 GO:0050909 denotes taste
T3651 22433-22438 SO_EXT:0000704 denotes genes
T3650 22377-22384 SO_EXT:0000704 denotes genetic
T3649 22366-22376 GO_PATO_EXT:biological_behavior denotes Behavioral
T3648 22334-22339 PR_EXT:000036337 denotes Tas2r
T3647 22308-22322 GO_SO_EXT:sequence_rearrangement_process denotes recombinations
T3646 22264-22270 PR_EXT:000036337 denotes Tas2rs
T3645 22209-22223 GO_SO_EXT:sequence_rearrangement_process denotes recombinations
T3644 22134-22139 GO:0050909 denotes taste
T3643 22126-22133 CHEBI:15854 denotes quinine
T3642 22107-22113 PR_EXT:000036337 denotes Tas2rs
T3641 22007-22010 SO_EXT:0000771 denotes QTL
T3640 21931-21938 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T3638 21842-21852 GO_SO_EXT:chromosome denotes chromosome
T3637 21811-21824 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T3636 21742-21754 GO:0050913 denotes bitter taste
T3635 21638-21643 GO:0050909 denotes taste
T3634 21630-21637 CHEBI:15854 denotes quinine
T3633 21613-21616 SO_EXT:0000771 denotes QTL
T3632 21511-21519 GO_EXT:0004872 denotes receptor
T3631 21482-21489 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T3630 21468-21480 GO_EXT:0005216 denotes ion channels
T3629 21468-21471 CHEBI:24870 denotes ion
T3628 21459-21467 SO_EXT:sequence_coding_function denotes encoding
T3627 21453-21458 SO_EXT:0000704 denotes genes
T3626 21417-21422 SO_EXT:0000704 denotes genes
T3625 21411-21416 PR_EXT:000036337 denotes Tas2r
T3624 21377-21387 GO_SO_EXT:chromosome denotes chromosome
T3623 21370-21373 SO_EXT:0000771 denotes QTL
T3622 21336-21341 GO:0050909 denotes taste
T3621 21328-21335 CHEBI:15854 denotes quinine
T3620 21312-21317 SO_EXT:0000704 denotes genic
T3619 21060-21067 CHEBI:15854 denotes quinine
T3618 20968-20971 PR_EXT:000036337 denotes T2R
T3617 20951-20956 GO:0050909 denotes taste
T3616 20943-20950 CHEBI:15854 denotes quinine
T3615 20898-20903 CL_GO_EXT:cell denotes cells
T3614 20883-20903 CL:0000209 denotes taste receptor cells
T3613 20883-20897 GO_EXT:0008527 denotes taste receptor
T3612 20883-20888 GO:0050909 denotes taste
T3611 20868-20879 GO_EXT:0005267 denotes K+ channels
T3610 20868-20870 CHEBI:29103 denotes K+
T3609 20832-20853 GO:0006812 denotes cationic conductances
T3608 20832-20840 CHEBI:36916 denotes cationic
T3607 20820-20828 CHEBI_PR_EXT:protein denotes proteins
T3606 20788-20795 CHEBI:15854 denotes quinine
T3605 20746-20759 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T3604 20715-20722 CHEBI:15854 denotes quinine
T3603 20653-20661 GO:0016020 denotes membrane
T3602 20644-20649 CL_GO_EXT:cell denotes cells
T3601 20618-20627 GO_EXT:0004872 denotes receptors
T3600 20581-20585 PR_EXT:000036337 denotes T2Rs
T3599 20559-20566 CHEBI:15854 denotes quinine
T3598 20502-20514 GO:0050913 denotes bitter taste
T3597 20425-20432 SO_EXT:0000704 denotes genetic
T3596 20411-20416 CL_GO_EXT:cell denotes cells
T3595 20396-20416 CL:0000209 denotes taste receptor cells
T3594 20396-20410 GO_EXT:0008527 denotes taste receptor
T3593 20396-20401 GO:0050909 denotes taste
T3592 20382-20392 GO:0010467 denotes expression
T3591 20356-20363 SO_EXT:0000704 denotes gene(s)
T3590 20286-20292 PR_EXT:000036337 denotes Tas2rs
T3589 20267-20279 GO:0050913 denotes bitter taste
T3588 20225-20233 CHEBI_PR_EXT:protein denotes proteins
T3587 20213-20217 PR_EXT:000013555 denotes Prh1
T3586 20204-20208 PR_EXT:000013555 denotes Prp2
T3585 20194-20202 CHEBI_PR_EXT:protein denotes proteins
T3584 20185-20193 UBERON:0001836 denotes salivary
T3583 20172-20179 CHEBI_SO_EXT:proline denotes proline
T3582 20165-20171 SO_EXT:sequence_coding_function denotes encode
T3581 20154-20159 SO_EXT:0000704 denotes genes
T3580 20103-20108 SO_EXT:0000704 denotes genes
T3579 20078-20083 SO_EXT:0000704 denotes genes
T3578 20072-20077 PR_EXT:000036337 denotes Tas2r
T3577 20042-20052 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes chromosome
T3576 20025-20034 _FRAGMENT denotes region on
T3575 20023-20024 CHEBI_SO_EXT:base denotes b
T3574 20009-20012 SO_EXT:0000771 denotes QTL
T3573 20003-20008 GO:0050909 denotes taste
T3572 19995-20002 CHEBI:15854 denotes quinine
T3571 19963-19970 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T3570 19951-19962 GO_SO_EXT:chromosome denotes chromosomal
T3569 19895-19900 GO:0050909 denotes taste
T3568 19829-19843 GO:0050913 denotes bitter-tasting
T3566 19755-19762 CHEBI:15854 denotes quinine
T3565 19744-19754 GO:0065007 denotes regulating
T3564 19715-19720 GO:0050909 denotes taste
T3563 19686-19689 CHEBI:15854 denotes Qui
T3562 19678-19684 GO:0007631 denotes intake
T3561 19670-19677 CHEBI:15854 denotes quinine
T3560 19662-19665 SO_EXT:0000771 denotes QTL
T3559 19614-19634 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes chromosomal position
T3558 19593-19596 SO_EXT:0000771 denotes QTL
T3557 19582-19586 NCBITaxon:10088 denotes mice
T3556 19546-19551 GO:0050909 denotes taste
T3555 19490-19500 GO_SO_EXT:chromosome denotes chromosome
T3554 19476-19479 SO_EXT:0000771 denotes QTL
T3553 19397-19419 UBERON:0001017 denotes central nervous system
T3552 19380-19389 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T3551 19356-19375 GO:0001775 denotes cellular activation
T3550 19356-19364 CL_GO_EXT:cell denotes cellular
T3549 19342-19347 CL_GO_EXT:cell denotes cells
T3548 19327-19347 CL:0000209 denotes taste receptor cells
T3547 19327-19341 GO_EXT:0008527 denotes taste receptor
T3546 19327-19332 GO:0050909 denotes taste
T3544 19206-19213 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T3543 19195-19204 GO_EXT:0004872 denotes receptors
T3542 19160-19170 CHEBI_EXT:chemical_substance_or_polyatomic_entity denotes substances
T3541 19145-19159 GO:0050913 denotes bitter-tasting
T3540 19126-19136 CHEBI_EXT:chemical_substance_or_polyatomic_entity denotes chemically
T3539 19084-19091 NCBITaxon:40674 denotes mammals
T3538 19064-19080 UBERON:0001033 denotes gustatory system
T3537 19064-19073 GO:0050909 denotes gustatory
T2699 18023-18029 GO_EXT:taster denotes taster
T2698 17991-18000 SO_EXT:0001024 denotes haplotype
T2697 17965-17970 PR_EXT:000036337 denotes Tas2r
T2696 17906-17911 GO:0050909 denotes taste
T2695 17869-17873 SO_EXT:0000704 denotes gene
T2694 17863-17868 PR_EXT:000036337 denotes Tas2r
T2693 17846-17854 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T2692 17737-17742 PR_EXT:000036337 denotes Tas2r
T2691 17642-17652 GO_SO_EXT:chromosome denotes chromosome
T2690 17603-17616 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T2689 17536-17540 SO_EXT:0000704 denotes gene
T2688 17518-17526 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T2687 17481-17492 SO_EXT:0000006 denotes PCR product
T2686 17458-17462 NCBITaxon:10088 denotes mice
T2685 17444-17451 SO_EXT:sequence_deletion_process denotes deleted
T2684 17418-17426 PR_EXT:000016902 denotes Tas2r120
T2683 17368-17392 GO_EXT:0015666 denotes restriction endonuclease
T2682 17338-17346 PR_EXT:000016896 denotes Tas2r110
T2681 17325-17333 PR_EXT:000016898 denotes Tas2r114
T2680 17315-17323 PR_EXT:000016891 denotes Tas2r104
T2679 17308-17313 SO_EXT:0000704 denotes genes
T2660 16114-16122 CL_GO_EXT:cell denotes cellular
T2659 16109-16122 GO:0005576 denotes extracellular
T2658 16071-16078 SO_EXT:sequence_alteration_entity_or_process denotes changes
T2657 16060-16070 CHEBI_SO_EXT:amino_acid denotes amino acid
T2656 16038-16047 GO_EXT:0004872 denotes receptors
T2655 15999-16005 PR_EXT:000036337 denotes Tas2rs
T2654 15972-15980 CHEBI_EXT:residue denotes residues
T2653 15960-15971 SO_EXT:polymorphism denotes polymorphic
T2652 15920-15932 SO_EXT:0000195 denotes coding exons
T2651 15876-15886 CHEBI_SO_EXT:nucleotide denotes nucleotide
T2650 15869-15900 SO_EXT:0000694 denotes single nucleotide polymorphisms
T2649 15855-15859 NCBITaxon:10088 denotes mice
T2648 15834-15841 SO_EXT:0001023 denotes alleles
T2647 15803-15809 PR_EXT:000036337 denotes Tas2rs
T2646 15785-15794 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T2645 15776-15784 SO_EXT:missense_quality_or_entity denotes missense
T2644 15740-15746 PR_EXT:000036337 denotes Tas2rs
T2643 15695-15706 SO_EXT:0000336 denotes pseudogenes
T2642 15682-15687 SO_EXT:0000704 denotes genes
T2641 15632-15644 GO_SO_EXT:frameshift_entity_or_process denotes frame shifts
T2640 15610-15619 SO_EXT:sequence_deletion_entity_or_process denotes deletions
T2639 15590-15599 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T2638 15581-15589 SO_EXT:missense_quality_or_entity denotes missense
T2637 15552-15560 PR_EXT:000016900 denotes Tas2r117
T2636 15539-15547 PR_EXT:000016890 denotes Tas2r103
T2635 15530-15537 SO_EXT:0001023 denotes alleles
T2634 15517-15521 NCBITaxon:10088 denotes mice
T2633 15503-15510 SO_EXT:sequence_deletion_process denotes deleted
T2632 15494-15499 PR_EXT:000036337 denotes Tas2r
T2631 15435-15451 CHEBI_SO_EXT:oligonucleotide denotes oligonucleotides
T2630 15391-15394 CHEBI_SO_EXT:DNA denotes DNA
T2629 15383-15394 SO_EXT:genomic_DNA denotes genomic DNA
T2628 15342-15350 PR_EXT:000016902 denotes Tas2r120
T2627 15298-15308 CHEBI_SO_EXT:amino_acid denotes amino acid
T2626 15251-15259 PR_EXT:000016904 denotes Tas2r124
T2625 15238-15246 PR_EXT:000016893 denotes Tas2r106
T2624 15220-15227 SO_EXT:0001023 denotes alleles
T2623 15214-15219 PR_EXT:000036337 denotes Tas2r
T2622 15160-15171 SO_EXT:0000855 denotes orthologues
T2621 15137-15146 SO_EXT:biological_sequence denotes sequences
T2620 15095-15102 SO_EXT:0000440 denotes vectors
T2619 15087-15094 SO_EXT:sequence_cloning_process denotes cloning
T2618 15054-15066 SO_EXT:0000006 denotes PCR products
T2617 15049-15052 CHEBI_SO_EXT:DNA denotes DNA
T2616 15041-15052 SO_EXT:genomic_DNA denotes genomic DNA
T2615 15017-15032 SO_EXT:coding_sequence denotes coding sequence
T2614 15011-15016 PR_EXT:000036337 denotes Tas2r
T2613 14985-14991 CHEBI_SO_EXT:oligonucleotide denotes oligos
T2612 14942-14947 PR_EXT:000036337 denotes Tas2r
T2611 14911-14926 SO_EXT:coding_sequence denotes coding sequence
T2610 14898-14906 SO:0000357 denotes flanking
T2609 14883-14889 SO_EXT:sequence_coding_function denotes coding
T2608 14859-14875 CHEBI_SO_EXT:oligonucleotide denotes oligonucleotides
T2606 14798-14808 GO_SO_EXT:chromosome denotes chromosome
T2605 14750-14761 SO_EXT:0000336 denotes pseudogenes
T2604 14744-14749 PR_EXT:000036337 denotes Tas2r
T2603 14710-14716 PR_EXT:000036337 denotes Tas2rs
T2602 14660-14665 GO:0050909 denotes taste
T2601 14624-14629 PR_EXT:000036337 denotes Tas2r
T2600 14593-14608 SO_EXT:coding_sequence denotes coding sequence
T2599 14573-14581 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T2598 14561-14569 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T2597 14433-14440 CHEBI_PR_EXT:protein denotes protein
T2596 14415-14425 GO:0010467 denotes expression
T2595 14400-14406 SO_EXT:0001023 denotes allele
T2594 14394-14399 PR_EXT:000036337 denotes Tas2r
T2593 14367-14385 SO_EXT:0005836 denotes regulatory regions
T2592 14367-14377 GO:0065007 denotes regulatory
T2591 14357-14363 SO_EXT:sequence_coding_function denotes coding
T2590 14341-14350 SO_EXT:sequence_alteration_entity_or_process denotes Mutations
T2589 14317-14335 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling cascades
T2588 14285-14293 GO_EXT:0004872 denotes receptor
T2587 14274-14281 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T2586 14267-14273 CHEBI_GO_EXT:ligand denotes ligand
T2585 14241-14248 CHEBI_PR_EXT:protein denotes protein
T2584 14227-14233 SO_EXT:0001023 denotes allele
T2583 14221-14226 PR_EXT:000036337 denotes Tas2r
T2582 14201-14212 SO_EXT:0000195 denotes coding exon
T2581 14177-14186 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T2580 14168-14176 SO_EXT:missense_quality_or_entity denotes Missense
T2579 14158-14162 NCBITaxon:10088 denotes mice
T2578 14094-14101 SO_EXT:sequence_deletion_process denotes deleted
T2577 14076-14086 SO_EXT:0000336 denotes pseudogene
T2576 14064-14070 SO_EXT:0001023 denotes allele
T2575 14058-14063 PR_EXT:000036337 denotes Tas2r
T2574 13995-14000 SO_EXT:0000704 denotes genes
T2573 13989-13994 PR_EXT:000036337 denotes Tas2r
T2572 13948-13951 SO_EXT:0000771 denotes QTL
T2571 13930-13935 GO:0050909 denotes taste
T2570 13912-13922 GO_SO_EXT:chromosome denotes chromosome
T2569 13892-13898 PR_EXT:000036337 denotes Tas2rs
T2568 13867-13874 SO_EXT:0001023 denotes alleles
T2567 13863-13866 PR_EXT:000036337 denotes T2R
T1945 12825-12828 SO_EXT:0000771 denotes QTL
T1944 12807-12812 GO:0050909 denotes taste
T1943 12750-12756 PR_EXT:000036337 denotes Tas2rs
T1942 12696-12705 CHEBI:36357 denotes compounds
T1941 12681-12695 GO:0050913 denotes bitter-tasting
T1940 12625-12630 CL_GO_EXT:cell denotes cells
T1939 12610-12630 CL:0000209 denotes taste receptor cells
T1938 12610-12624 GO_EXT:0008527 denotes taste receptor
T1937 12610-12615 GO:0050909 denotes taste
T1936 12596-12606 GO:0010467 denotes expression
T1935 12569-12575 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T1934 12469-12470 CHEBI_SO_EXT:base denotes b
T1933 12429-12433 PR_EXT:000036337 denotes T2Rs
T1932 12418-12424 SO_EXT:sequence_coding_function denotes encode
T1931 12405-12410 SO_EXT:0000704 denotes genes
T1930 12399-12404 PR_EXT:000036337 denotes Tas2r
T1929 12378-12393 GO_EXT:0008527 denotes taste receptors
T1928 12378-12383 GO:0050909 denotes taste
T1927 12369-12393 PR_EXT:000036337 denotes T2R-type taste receptors
T1926 12354-12363 GO_EXT:0004872 denotes receptors
T1925 12337-12341 CL_GO_EXT:cell denotes cell
T1924 12322-12341 CL:0000623 denotes natural killer cell
T1923 12303-12311 GO_EXT:0004872 denotes receptor
T1922 12275-12281 SO_EXT:sequence_coding_function denotes encode
T1921 12244-12249 SO_EXT:0000704 denotes genes
T1920 12191-12192 CHEBI_SO_EXT:base denotes b
T1919 12169-12172 SO_EXT:0000771 denotes QTL
T1918 12156-12166 GO_SO_EXT:chromosome denotes chromosome
T1917 12117-12123 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T1916 12094-12100 SO_EXT:0001026 denotes genome
T1915 11994-12001 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T1914 11948-11954 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T1913 11910-11926 SO_EXT:physical_mapping_process denotes Physical mapping
T1912 11776-11781 NCBITaxon:10088 denotes mouse
T1911 11782-11792 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes chromosome
T1910 11765-11775 _FRAGMENT denotes portion of
T1909 11714-11717 SO_EXT:0000771 denotes QTL
T1908 11693-11696 SO_EXT:0000771 denotes QTL
T1907 11615-11623 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T1906 11579-11587 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T1905 11554-11559 GO:0050909 denotes taste
T1904 11511-11515 NCBITaxon:10088 denotes mice
T1903 11433-11442 SO_EXT:genotype_or_entity_with_genotype denotes genotypes
T1902 11355-11361 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T1901 11196-11209 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T1900 11127-11133 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T1899 11109-11112 SO_EXT:0000771 denotes QTL
T1898 11054-11061 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T1897 10999-11005 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T1896 10978-10979 GO:0050909 denotes s
T1895 10972-10975 SO_EXT:0000771 denotes QTL
T1894 10960-10969 GO_SO_EXT:chromosome denotes hromosome
T1893 10956-10958 GO_SO_EXT:chromosome denotes he
T1892 10955-10956 SO_EXT:0000771 denotes T
T1891 10563-10569 SO_EXT:0001026 denotes genome
T1890 10512-10515 SO_EXT:0000771 denotes QTL
T1889 10458-10468 GO_SO_EXT:chromosome denotes chromosome
T1888 10451-10454 SO_EXT:0000771 denotes QTL
T1887 10429-10435 SO_EXT:0001026 denotes genome
T1886 10376-10386 GO_SO_EXT:chromosome denotes chromosome
T1885 10326-10329 SO_EXT:0000771 denotes QTL
T1884 10304-10310 SO_EXT:0001026 denotes genome
T1883 10231-10237 SO_EXT:0001026 denotes genome
T1882 10178-10189 GO_SO_EXT:chromosome denotes chromosomes
T1881 10167-10174 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T1880 10113-10118 GO:0050909 denotes taste
T1521 9818-9823 GO:0050909 denotes taste
T1520 9694-9698 NCBITaxon:10088 denotes mice
T1519 9647-9651 NCBITaxon:10088 denotes mice
T69 334-338 PR_EXT:000036337 denotes T2Rs
T70 350-359 GO:0010467 denotes expressed
T71 374-379 GO:0050909 denotes taste
T72 374-388 GO_EXT:0008527 denotes taste receptor
T73 374-394 CL:0000209 denotes taste receptor cells
T74 389-394 CL_GO_EXT:cell denotes cells
T75 402-408 UBERON:0001723 denotes tongue
T76 457-465 GO_EXT:0004872 denotes receptor
T77 559-566 CHEBI:15854 denotes quinine
T78 567-580 CHEBI:17883 denotes hydrochloride
T79 603-611 CHEBI:16150 denotes benzoate
T80 648-658 GO_PATO_EXT:biological_behavior denotes behavioral
T81 659-664 GO:0050909 denotes taste
T82 683-694 GO_SO_EXT:sequence_rearrangement_process denotes recombinant
T83 707-712 NCBITaxon:10088 denotes mouse
T84 738-762 SO_EXT:0000771 denotes quantitative trait locus
T85 764-767 SO_EXT:0000771 denotes QTL
T86 773-778 GO:0050909 denotes taste
T87 805-808 SO_EXT:0000771 denotes QTL
T88 832-833 CHEBI_SO_EXT:base denotes b
T89 834-856 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes interval on chromosome
T90 876-881 SO_EXT:0000704 denotes genes
T91 882-890 SO_EXT:sequence_coding_function denotes encoding
T92 891-895 PR_EXT:000036337 denotes T2Rs
T93 897-903 PR_EXT:000036337 denotes Tas2rs
T94 906-912 PR_EXT:000036337 denotes Tas2rs
T95 948-961 SO_EXT:coding_sequence denotes coding region
T96 962-993 SO_EXT:0000694 denotes single nucleotide polymorphisms
T97 969-979 CHEBI_SO_EXT:nucleotide denotes nucleotide
T98 995-999 SO_EXT:0000694 denotes SNPs
T99 1055-1062 CHEBI:15854 denotes quinine
T100 1086-1093 CHEBI:15854 denotes quinine
T101 1135-1144 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T102 1223-1228 PR_EXT:000036337 denotes Tas2r
T103 1229-1236 SO_EXT:0001023 denotes alleles
T104 1285-1290 PR_EXT:000036337 denotes Tas2r
T105 1291-1298 SO_EXT:0001023 denotes alleles
T106 1359-1366 SO_EXT:0001023 denotes alleles
T107 1385-1390 PR_EXT:000036337 denotes Tas2r
T108 1417-1426 SO_EXT:0001024 denotes haplotype
T109 1448-1455 CHEBI:15854 denotes quinine
T110 1456-1462 GO_EXT:taster denotes taster
T111 1516-1521 GO:0050909 denotes taste
T112 1553-1556 SO_EXT:0000771 denotes QTL
T113 1561-1568 CHEBI:15854 denotes quinine
T114 1569-1574 GO:0050909 denotes taste
T115 1592-1595 PR_EXT:000036337 denotes T2R
T116 1681-1688 CHEBI:15854 denotes quinine
T117 1689-1694 GO:0050909 denotes taste
T594 1960-1967 NCBITaxon:33208 denotes Animals
T595 1976-1985 GO:0050909 denotes gustatory
T596 1976-1992 UBERON:0001033 denotes gustatory system
T597 2022-2026 CHEBI_EXT:33290 denotes food
T598 2049-2062 GO:0050916 denotes sweet-tasting
T599 2063-2068 CHEBI_EXT:33290 denotes foods
T600 2126-2140 GO:0050913 denotes bitter-tasting
T601 2141-2146 CHEBI_EXT:33290 denotes foods
T602 2167-2177 CHEBI_EXT:chemical_substance_or_polyatomic_entity denotes substances
T603 2222-2249 GO_PR_EXT:G_protein_coupled_receptor denotes G protein-coupled receptors
T604 2224-2231 CHEBI_PR_EXT:protein denotes protein
T605 2251-2256 GO_PR_EXT:G_protein_coupled_receptor denotes GPCRs
T606 2258-2267 GO:0010467 denotes expressed
T607 2289-2294 GO:0050909 denotes taste
T608 2289-2303 GO_EXT:0008527 denotes taste receptor
T609 2289-2309 CL:0000209 denotes taste receptor cells
T610 2304-2309 CL_GO_EXT:cell denotes cells
T611 2311-2315 CL:0000209 denotes TRCs
T612 2324-2333 GO:0050909 denotes gustatory
T613 2324-2344 UBERON:0002926 denotes gustatory epithelium
T614 2373-2402 _FRAGMENT denotes detection and transduction of
T615 2410-2416 _FRAGMENT denotes bitter
T616 2445-2450 GO:0001580 denotes taste
T617 2421-2426 _FRAGMENT denotes umami
T618 2445-2450 GO:0046535 denotes taste
T619 2373-2408 _FRAGMENT denotes detection and transduction of sweet
T620 2445-2450 GO:0001582 denotes taste
T621 2434-2443 CHEBI_EXT:glutamate denotes glutamate
T622 2452-2456 PR_EXT:000036336 denotes T1Rs
T623 2461-2467 _FRAGMENT denotes sweet-
T624 2477-2484 GO:0050916 denotes tasting
T625 2471-2484 GO:0050917 denotes umami-tasting
T626 2504-2508 PR_EXT:000036337 denotes T2Rs
T627 2513-2527 GO:0050913 denotes bitter-tasting
T628 2528-2537 CHEBI:36357 denotes compounds
T629 2550-2555 SO_EXT:0000704 denotes genes
T630 2561-2567 SO_EXT:sequence_coding_function denotes encode
T631 2568-2572 PR_EXT:000036337 denotes T2Rs
T632 2578-2584 PR_EXT:000036337 denotes Tas2rs
T633 2630-2639 NCBITaxon:40674 denotes mammalian
T634 2640-2647 SO_EXT:0001026 denotes genomes
T635 2653-2664 GO_SO_EXT:chromosome denotes chromosomal
T636 2665-2672 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T637 2709-2721 GO:0050913 denotes bitter taste
T638 2748-2752 NCBITaxon:10088 denotes mice
T639 2770-2776 PR_EXT:000036337 denotes Tas2rs
T640 2815-2825 GO_SO_EXT:chromosome denotes chromosome
T641 2842-2847 NCBITaxon:9606 denotes human
T642 2848-2854 PR_EXT:000036337 denotes Tas2rs
T643 2868-2879 SO_EXT:0000336 denotes pseudogenes
T644 2896-2901 NCBITaxon:10088 denotes mouse
T645 2902-2908 PR_EXT:000036337 denotes Tas2rs
T646 2922-2933 SO_EXT:0000336 denotes pseudogenes
T647 2946-2950 NCBITaxon:10088 denotes mice
T648 3005-3012 GO_EXT:reaction_or_response denotes respond
T649 3058-3068 GO:0010467 denotes expression
T650 3120-3124 SO_EXT:0000704 denotes gene
T651 3140-3152 GO:0050913 denotes bitter taste
T652 3192-3215 SO_EXT:0000771 denotes quantitative trait loci
T653 3217-3220 SO_EXT:0000771 denotes QTL
T654 3269-3275 GO:0007631 denotes intake
T655 3301-3306 NCBITaxon:10088 denotes mouse
T656 3327-3334 CHEBI:15854 denotes quinine
T657 3336-3339 CHEBI:15854 denotes Qui
T658 3353-3366 CHEBI:27641 denotes cyclohexamide
T659 3368-3371 CHEBI:27641 denotes Cyx
T660 3446-3449 SO_EXT:0000771 denotes QTL
T661 3457-3462 NCBITaxon:10088 denotes mouse
T662 3470-3480 GO_SO_EXT:chromosome denotes chromosome
T663 3505-3511 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T664 3562-3568 PR_EXT:000036337 denotes Tas2rs
T665 3584-3590 SO_EXT:0001026 denotes genome
T666 3715-3726 GO_SO_EXT:chromosome denotes chromosomal
T667 3727-3734 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T668 3749-3760 GO_SO_EXT:sequence_rearrangement_process denotes recombinant
T669 3883-3886 SO_EXT:0000771 denotes QTL
T670 3927-3939 GO:0050913 denotes bitter taste
T671 3940-3944 SO_EXT:0000771 denotes QTLs
T672 3955-3965 GO_PATO_EXT:biological_behavior denotes behavioral
T673 3987-3998 GO:0007631 denotes consumption
T674 4051-4060 GO:0007631 denotes ingestive
T675 4164-4176 GO:0050913 denotes bitter taste
T676 4177-4186 GO_PATO_EXT:biological_behavior denotes behaviors
T677 4260-4264 SO_EXT:0000771 denotes QTLs
T678 4268-4280 GO:0050913 denotes bitter taste
T679 4322-4335 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T680 4389-4400 CHEBI_EXT:59941 denotes amphiphilic
T681 4408-4417 CHEBI:36357 denotes compounds
T682 4427-4434 CHEBI:15854 denotes quinine
T683 4450-4458 CHEBI:16150 denotes benzoate
T684 4474-4479 GO:0050909 denotes taste
T685 4474-4488 GO_EXT:0008527 denotes taste receptor
T686 4474-4494 CL:0000209 denotes taste receptor cells
T687 4489-4494 CL_GO_EXT:cell denotes cells
T688 4512-4517 GO_PR_EXT:G_protein_coupled_receptor denotes GPCRs
T689 4531-4538 CHEBI:15854 denotes Quinine
T690 4563-4571 CHEBI_PR_EXT:protein denotes proteins
T691 4582-4589 CHEBI:15854 denotes quinine
T692 4615-4617 CHEBI:29103 denotes K+
T693 4615-4626 GO_EXT:0005267 denotes K+ channels
T694 4637-4645 CHEBI:27732 denotes caffeine
T695 4655-4669 GO:0050913 denotes bitter-tasting
T696 4670-4679 CHEBI_EXT:chemical_substance_or_polyatomic_entity denotes substance
T697 4699-4712 GO:0005622 denotes intracellular
T698 4704-4712 CL_GO_EXT:cell denotes cellular
T699 4713-4730 GO_EXT:0008081 denotes phosphodiesterase
T700 4776-4779 PR_EXT:000036337 denotes T2R
T701 4794-4797 PR_EXT:000036337 denotes T2R
T702 4889-4894 GO:0050909 denotes taste
T703 4945-4950 GO:0050909 denotes taste
T704 5012-5023 GO_SO_EXT:sequence_rearrangement_process denotes recombinant
T705 5036-5040 NCBITaxon:10088 denotes mice
T706 5064-5071 CHEBI:15854 denotes quinine
T707 5072-5085 CHEBI:17883 denotes hydrochloride
T708 5108-5116 CHEBI:16150 denotes benzoate
T709 5181-5192 GO_SO_EXT:chromosome denotes chromosomal
T710 5193-5200 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T711 5220-5223 SO_EXT:0000771 denotes QTL
T712 5233-5238 GO:0050909 denotes taste
T713 5248-5249 CHEBI_SO_EXT:base denotes b
T714 5250-5261 _FRAGMENT denotes interval on
T715 5269-5279 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes chromosome
T716 5310-5315 PR_EXT:000036337 denotes Tas2r
T717 5316-5321 SO_EXT:0000704 denotes genes
T718 5361-5369 SO_EXT:biological_sequence denotes sequence
T719 5378-5383 PR_EXT:000036337 denotes Tas2r
T720 5384-5390 SO_EXT:0001023 denotes allele
T721 5479-5484 SO_EXT:0000704 denotes genes
T722 5489-5500 SO_EXT:polymorphism denotes polymorphic
T723 5544-5550 PR_EXT:000036337 denotes Tas2rs
T724 5569-5578 SO_EXT:0001024 denotes haplotype
T725 5605-5610 GO:0050909 denotes taste
T1500 5634-5639 GO:0050909 denotes Taste
T1501 5672-5675 SO_EXT:0000771 denotes QTL
T1502 5680-5692 GO:0050913 denotes bitter taste
T1503 5707-5718 GO:0007631 denotes consumption
T1504 5777-5786 GO:0007631 denotes ingestive
T1505 5932-5936 NCBITaxon:10088 denotes mice
T1506 5960-5965 GO:0050909 denotes taste
T1507 5985-5990 GO:0050909 denotes taste
T1508 6048-6052 NCBITaxon:10088 denotes mice
T1509 6150-6156 CHEBI_GO_EXT:ligand denotes ligand
T1510 6181-6189 CHEBI:36357 denotes compound
T1511 6243-6248 GO:0050909 denotes taste
T1512 6364-6368 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T1513 6373-6379 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T1514 6390-6394 NCBITaxon:10088 denotes mice
T1515 6493-6502 CHEBI:36357 denotes compounds
T1516 6625-6629 NCBITaxon:10088 denotes mice
T1517 6674-6678 NCBITaxon:10088 denotes mice
T1518 6766-6771 GO:0050909 denotes taste
T2607 14825-14829 NCBITaxon:10088 denotes mice
T3639 21855-21860 PR_EXT:000036337 denotes Tas2r
T7343 6893-6897 NCBITaxon:10088 denotes mice
T54 0-10 SO_EXT:0001024 denotes Haplotypes
T55 18-23 PR_EXT:000036337 denotes Tas2r
T56 24-32 _FRAGMENT denotes locus on
T57 40-50 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes chromosome
T58 63-70 CHEBI:15854 denotes quinine
T59 71-76 GO:0050909 denotes taste
T60 99-103 NCBITaxon:10088 denotes mice
T61 142-156 GO:0050913 denotes bitter-tasting
T62 157-166 CHEBI:36357 denotes compounds
T63 174-183 GO:0050909 denotes gustatory
T64 174-190 UBERON:0001033 denotes gustatory system
T65 211-218 NCBITaxon:33208 denotes animals
T66 256-260 CHEBI_EXT:33290 denotes food
T67 313-318 GO:0050909 denotes taste
T68 313-328 GO_EXT:0008527 denotes taste receptors
T1879 10085-10089 SO_EXT:0000771 denotes QTLs
T1878 9985-9988 SO_EXT:0000771 denotes QTL
T118 1741-1754 SO_EXT:polymorphism denotes polymorphisms
T119 1762-1774 SO_EXT:0000195 denotes coding exons
T120 1782-1787 PR_EXT:000036337 denotes Tas2r
T121 1863-1875 GO:0050913 denotes bitter taste
T122 1901-1904 PR_EXT:000036337 denotes T2R
T123 1905-1914 GO_EXT:0004872 denotes receptors
T124 1937-1946 SO_EXT:sequence_variation_entity_or_quality denotes variation
T2678 17275-17281 SO_EXT:0001023 denotes allele
T2677 17233-17244 SO_EXT:0000006 denotes PCR product
T2676 17227-17232 PR_EXT:000036337 denotes Tas2r
T2675 17133-17157 GO_EXT:0015666 denotes restriction endonuclease
T2674 17058-17065 SO_EXT:0001023 denotes alleles
T2673 17052-17057 PR_EXT:000036337 denotes Tas2r
T2672 17029-17034 GO:0050909 denotes taste
T2671 16956-16959 CHEBI_SO_EXT:DNA denotes DNA
T2670 16948-16959 SO_EXT:genomic_DNA denotes genomic DNA
T2669 16895-16900 GO:0050909 denotes taste
T2668 16862-16869 SO_EXT:0001023 denotes alleles
T2667 16856-16861 PR_EXT:000036337 denotes Tas2r
T2666 16831-16834 SO_EXT:0000771 denotes QTL
T2665 16825-16830 GO:0050909 denotes taste
T2664 16705-16714 GO_EXT:0004872 denotes receptors
T2663 16693-16704 SO:0000858 denotes orthologous
T2662 16669-16670 PR_EXT:000036337 denotes T
T2661 16136-16140 PR_EXT:000036337 denotes T2Rs
T3567 19814-19825 GO:0007631 denotes consumption
T3739 24827-24837 NCBITaxon:subspecies denotes subspecies
R5153 T6863 T6862 _lexicallyChainedTo positions,chromosome
R344 T57 T56 _lexicallyChainedTo chromosome,locus on
R352 T615 T614 _lexicallyChainedTo bitter,detection and transduction of
R353 T616 T615 _lexicallyChainedTo taste,bitter
R354 T617 T614 _lexicallyChainedTo umami,detection and transduction of
R355 T618 T617 _lexicallyChainedTo taste,umami
R356 T620 T619 _lexicallyChainedTo taste,detection and transduction of sweet
R357 T624 T623 _lexicallyChainedTo tasting,sweet-
R358 T715 T714 _lexicallyChainedTo chromosome,interval on
R1370 T1911 T1910 _lexicallyChainedTo chromosome,portion of
R2527 T3577 T3576 _lexicallyChainedTo chromosome,region on
R2528 T3658 T3657 _lexicallyChainedTo taste,sweet

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T7192 18933-18942 SO:0001024 denotes haplotype
T7191 18927-18932 PR:000036337 denotes Tas2r
T7190 18831-18840 SO:0001024 denotes haplotype
T7189 18825-18830 PR:000036337 denotes Tas2r
T7188 18777-18782 GO:0050909 denotes taste
T7187 18731-18735 NCBITaxon:10088 denotes mice
T7186 18647-18651 NCBITaxon:10088 denotes mice
T7185 18626-18635 SO:0001024 denotes haplotype
T7184 18605-18614 SO:0001024 denotes haplotype
T7183 18591-18600 SO:0001024 denotes haplotype
T7182 18585-18590 PR:000036337 denotes Tas2r
T7181 18483-18488 GO:0050909 denotes taste
T7180 18447-18452 PR:000036337 denotes Tas2r
T7082 18338-18344 SO:0001023 denotes allele
T7081 18320-18326 SO:0001023 denotes allele
T7080 18237-18242 PR:000036337 denotes Tas2r
T7079 18193-18200 SO:0001026 denotes genomic
T7078 18137-18143 PR:000036337 denotes Tas2rs
T7077 18111-18122 SO:0000195 denotes coding exon
T7076 18101-18105 NCBITaxon:10088 denotes mice
T7075 18078-18087 SO:0001024 denotes haplotype
T7074 18052-18057 PR:000036337 denotes Tas2r
T6955 16341-16349 PR:000016892 denotes Tas2r105
T6954 16327-16339 SO:0000006 denotes PCR products
T6953 16245-16251 PR:000036337 denotes Tas2rs
T6952 16229-16236 SO:0001023 denotes alleles
T6951 16211-16217 PR:000036337 denotes Tas2rs
T6950 16169-16176 SO:0001023 denotes Allelic
T6845 13854-13860 SO:0001026 denotes genome
T6844 13751-13755 PR:000013555 denotes Prh1
T6843 13742-13746 PR:000013555 denotes Prp2
T6842 13723-13731 UBERON:0001836 denotes salivary
T6841 13695-13700 SO:0000704 denotes genes
T6840 13596-13602 PR:000036337 denotes Tas2rs
T6839 13550-13555 SO:0000704 denotes genes
T6838 13544-13549 PR:000036337 denotes Tas2r
T6837 13510-13515 PR:000036337 denotes Tas2r
T6682 13407-13413 SO:0001026 denotes genome
T6681 13401-13406 NCBITaxon:10088 denotes mouse
T6680 13272-13278 PR:000036337 denotes Tas2rs
T6679 13239-13251 GO:0050913 denotes bitter taste
T6678 13144-13147 SO:0000771 denotes QTL
T6677 13105-13111 SO:0001026 denotes genome
T6676 12849-12852 SO:0000771 denotes QTL
T6959 16471-16476 PR:000036337 denotes Tas2r
T6958 16422-16430 PR:000016902 denotes Tas2r120
T6957 16409-16420 SO:0000006 denotes PCR product
T6956 16351-16359 PR:000016899 denotes Tas2r116
T6584 10929-10935 SO:0001026 denotes genome
T6583 10873-10876 SO:0000771 denotes QTL
T6582 10808-10813 GO:0050909 denotes taste
T6581 10769-10772 SO:0000771 denotes QTL
T6580 10724-10727 SO:0000771 denotes QTL
T6579 10641-10646 NCBITaxon:10088 denotes mouse
T6578 10632-10637 GO:0050909 denotes taste
T6577 10619-10622 SO:0000771 denotes QTL
T6325 9623-9630 GO:0065007 denotes control
T6324 9617-9622 SO:0000704 denotes genic
T6323 9228-9233 GO:0050909 denotes taste
T6322 8790-8795 GO:0050909 denotes taste
T6321 8656-8660 NCBITaxon:10088 denotes mice
T6091 31069-31075 SO:0001023 denotes allele
T6090 31021-31032 SO:0000006 denotes PCR product
T6089 30994-31002 PR:000016902 denotes Tas2r120
T6088 30952-30959 SO:0001026 denotes genomic
T6087 30925-30930 PR:000036337 denotes Tas2r
T6086 30833-30840 SO:0001023 denotes alleles
T6085 30769-30786 SO:0000061 denotes restriction sites
T6084 30595-30605 CHEBI:33694 denotes Biopolymer
T6083 30465-30477 SO:0000006 denotes PCR products
T6082 30285-30292 SO:0001026 denotes genomic
T6081 30247-30252 PR:000036337 denotes Tas2r
T6080 30242-30246 SO:0000147 denotes exon
T6079 30209-30217 SO:0000357 denotes flanking
T6078 30164-30170 SO:0001026 denotes genome
T6077 30059-30066 SO:0001023 denotes alleles
T6076 30055-30058 PR:000036337 denotes T2R
T5360 29053-29057 NCBITaxon:10088 denotes mice
T5359 29010-29019 GO:0007608 denotes olfactory
T5358 28989-28994 GO:0050909 denotes taste
T5357 28967-28972 CHEBI:15377 denotes water
T5356 28929-28933 NCBITaxon:10088 denotes mice
T5355 28883-28888 CHEBI:15377 denotes water
T5354 28796-28801 CHEBI:15377 denotes water
T5353 28681-28688 NCBITaxon:33208 denotes animals
T5352 28658-28663 CHEBI:15377 denotes water
T5351 28617-28625 CHEBI:36357 denotes compound
T5350 28526-28533 CHEBI:17992 denotes sucrose
T5349 28518-28522 NCBITaxon:10088 denotes mice
T5348 28376-28380 NCBITaxon:10088 denotes mice
T5347 28269-28274 CHEBI:15377 denotes water
T5346 28243-28248 CHEBI:15377 denotes water
T5345 28156-28161 CHEBI:15377 denotes water
T5344 28065-28070 NCBITaxon:10088 denotes mouse
T5343 27977-27981 NCBITaxon:10088 denotes mice
T5342 27943-27948 CHEBI:15377 denotes water
T5341 27733-27740 CHEBI:17992 denotes sucrose
T5340 27689-27693 CHEBI:8502 denotes PROP
T5339 27630-27635 GO:0050909 denotes taste
T5338 27571-27575 NCBITaxon:10088 denotes Mice
T5337 27416-27420 NCBITaxon:10088 denotes mice
T5336 27341-27346 NCBITaxon:10088 denotes mouse
T5335 27245-27250 CHEBI:15377 denotes water
T5334 27137-27141 NCBITaxon:10088 denotes mice
T5333 27097-27102 CHEBI:15377 denotes water
T5332 27004-27008 NCBITaxon:10088 denotes mice
T5331 26979-26984 CHEBI:15377 denotes water
T5890 29924-29927 SO:0000771 denotes QTL
T5889 29768-29774 SO:0001026 denotes genome
T5888 29530-29533 SO:0000771 denotes QTL
T5887 29504-29528 SO:0000771 denotes quantitative trait locus
T5886 29187-29191 NCBITaxon:10088 denotes mice
T5885 29137-29140 SO:0000771 denotes QTL
T5058 26700-26706 NCBITaxon:33208 denotes Animal
T5057 26642-26648 NCBITaxon:33208 denotes animal
T5056 26588-26593 GO:0050909 denotes taste
T5055 26573-26578 CHEBI:15377 denotes water
T5054 26526-26534 CHEBI:75958 denotes solution
T5053 26451-26464 CHEBI:17883 denotes hydrochloride
T5052 26443-26450 CHEBI:15854 denotes quinine
T5051 26418-26438 CHEBI:8502 denotes 6-n-propylthiouracil
T5050 26408-26416 CHEBI:16150 denotes benzoate
T5049 26388-26395 CHEBI:17992 denotes Sucrose
T5048 26363-26370 CHEBI:33893 denotes reagent
T5047 26310-26315 GO:0050909 denotes Taste
T5046 26296-26302 NCBITaxon:9989 denotes rodent
T5045 26278-26282 CHEBI:33290 denotes food
T5044 26185-26189 NCBITaxon:10088 denotes mice
T5043 26142-26148 GO:0007618 denotes mating
T5042 26054-26058 NCBITaxon:10088 denotes mice
T5041 25915-25919 NCBITaxon:10088 denotes mice
T5040 25760-25764 NCBITaxon:10088 denotes mice
T5039 25738-25743 UBERON:0007023 denotes adult
T5038 25713-25722 CHEBI:75958 denotes solutions
T5037 25704-25708 NCBITaxon:10088 denotes Mice
T4862 25625-25636 CL:0000209 denotes taste cells
T4861 25625-25630 GO:0050909 denotes taste
T4860 25596-25606 GO:0010467 denotes expressing
T4859 25592-25595 PR:000036337 denotes T2R
T4858 25470-25474 PR:000036337 denotes T2Rs
T4857 25442-25447 NCBITaxon:10088 denotes mouse
T4856 25403-25406 PR:000036337 denotes T2R
T4855 25356-25361 GO:0050909 denotes taste
T4854 25348-25355 CHEBI:15854 denotes quinine
T4853 25317-25326 SO:0001024 denotes haplotype
T4852 25279-25283 NCBITaxon:10088 denotes mice
T4851 25197-25202 SO:0000704 denotes genes
T4850 25191-25196 PR:000036337 denotes Tas2r
T4849 25171-25174 PR:000036337 denotes T2R
T4848 25117-25122 GO:0050909 denotes taste
T4847 25109-25116 CHEBI:15854 denotes quinine
T4846 25070-25074 NCBITaxon:10088 denotes mice
T4845 25055-25060 SO:0000704 denotes genic
T4844 25012-25017 GO:0050909 denotes taste
T4843 24987-24994 CHEBI:15854 denotes quinine
T4842 24962-24976 GO:0050913 denotes bitter-tasting
T3494 22780-22789 CHEBI:32111 denotes saccharin
T3493 22764-22769 SO:0000704 denotes genes
T3492 22714-22720 NCBITaxon:9606 denotes humans
T3491 22693-22698 GO:0050909 denotes taste
T3490 22688-22691 CHEBI:46261 denotes PTC
T3489 22667-22686 CHEBI:46261 denotes phenylthiocarbamide
T3488 22617-22622 PR:000036337 denotes Tas2r
T3487 22539-22550 GO:0050917 denotes umami taste
T3486 22545-22550 GO:0050916 denotes taste
T3485 22529-22534 _FRAGMENT denotes sweet
T3484 22486-22490 SO:0000704 denotes gene
T3483 22479-22485 PR:000016062 denotes Tas1r3
T3482 22451-22456 GO:0050909 denotes taste
T3481 22433-22438 SO:0000704 denotes genes
T3480 22377-22384 SO:0000704 denotes genetic
T3479 22334-22339 PR:000036337 denotes Tas2r
T3478 22264-22270 PR:000036337 denotes Tas2rs
T3477 22134-22139 GO:0050909 denotes taste
T3476 22126-22133 CHEBI:15854 denotes quinine
T3475 22107-22113 PR:000036337 denotes Tas2rs
T3474 22007-22010 SO:0000771 denotes QTL
T3473 21855-21860 PR:000036337 denotes Tas2r
T3472 21742-21754 GO:0050913 denotes bitter taste
T3471 21638-21643 GO:0050909 denotes taste
T3470 21630-21637 CHEBI:15854 denotes quinine
T3469 21613-21616 SO:0000771 denotes QTL
T3468 21468-21471 CHEBI:24870 denotes ion
T3467 21453-21458 SO:0000704 denotes genes
T3466 21417-21422 SO:0000704 denotes genes
T3465 21411-21416 PR:000036337 denotes Tas2r
T3464 21370-21373 SO:0000771 denotes QTL
T3463 21336-21341 GO:0050909 denotes taste
T3462 21328-21335 CHEBI:15854 denotes quinine
T3461 21312-21317 SO:0000704 denotes genic
T3460 21060-21067 CHEBI:15854 denotes quinine
T3459 20968-20971 PR:000036337 denotes T2R
T3458 20951-20956 GO:0050909 denotes taste
T3457 20943-20950 CHEBI:15854 denotes quinine
T3456 20883-20903 CL:0000209 denotes taste receptor cells
T3455 20883-20888 GO:0050909 denotes taste
T3454 20868-20870 CHEBI:29103 denotes K+
T3453 20832-20853 GO:0006812 denotes cationic conductances
T3452 20832-20840 CHEBI:36916 denotes cationic
T3451 20788-20795 CHEBI:15854 denotes quinine
T3450 20715-20722 CHEBI:15854 denotes quinine
T3449 20653-20661 GO:0016020 denotes membrane
T3448 20581-20585 PR:000036337 denotes T2Rs
T3447 20559-20566 CHEBI:15854 denotes quinine
T3444 20396-20416 CL:0000209 denotes taste receptor cells
T3443 20396-20401 GO:0050909 denotes taste
T3442 20382-20392 GO:0010467 denotes expression
T3441 20356-20363 SO:0000704 denotes gene(s)
T3440 20286-20292 PR:000036337 denotes Tas2rs
T3439 20267-20279 GO:0050913 denotes bitter taste
T3438 20213-20217 PR:000013555 denotes Prh1
T3437 20204-20208 PR:000013555 denotes Prp2
T3436 20185-20193 UBERON:0001836 denotes salivary
T3435 20154-20159 SO:0000704 denotes genes
T3434 20103-20108 SO:0000704 denotes genes
T3433 20078-20083 SO:0000704 denotes genes
T3432 20072-20077 PR:000036337 denotes Tas2r
T3431 20009-20012 SO:0000771 denotes QTL
T3430 20003-20008 GO:0050909 denotes taste
T3429 19995-20002 CHEBI:15854 denotes quinine
T3428 19895-19900 GO:0050909 denotes taste
T3427 19829-19843 GO:0050913 denotes bitter-tasting
T3426 19814-19825 GO:0007631 denotes consumption
T3425 19755-19762 CHEBI:15854 denotes quinine
T3424 19744-19754 GO:0065007 denotes regulating
T3423 19715-19720 GO:0050909 denotes taste
T3422 19686-19689 CHEBI:15854 denotes Qui
T3421 19678-19684 GO:0007631 denotes intake
T3420 19670-19677 CHEBI:15854 denotes quinine
T3419 19662-19665 SO:0000771 denotes QTL
T3418 19593-19596 SO:0000771 denotes QTL
T3417 19582-19586 NCBITaxon:10088 denotes mice
T3416 19546-19551 GO:0050909 denotes taste
T3415 19476-19479 SO:0000771 denotes QTL
T3414 19397-19419 UBERON:0001017 denotes central nervous system
T3413 19356-19375 GO:0001775 denotes cellular activation
T3412 19327-19347 CL:0000209 denotes taste receptor cells
T3411 19327-19332 GO:0050909 denotes taste
T3410 19145-19159 GO:0050913 denotes bitter-tasting
T3409 19084-19091 NCBITaxon:40674 denotes mammals
T3408 19064-19080 UBERON:0001033 denotes gustatory system
T3407 19064-19073 GO:0050909 denotes gustatory
T3536 24827-24837 NCBITaxon:subspecies denotes subspecies
T3535 24816-24823 NCBITaxon:species denotes species
T3534 24810-24815 NCBITaxon:10088 denotes mouse
T3533 24778-24783 PR:000036337 denotes Tas2r
T3532 24719-24724 NCBITaxon:10088 denotes mouse
T3531 24692-24702 SO:0001024 denotes haplotypes
T3530 24686-24691 PR:000036337 denotes Tas2r
T3529 24605-24609 NCBITaxon:10088 denotes mice
T3528 24507-24514 NCBITaxon:species denotes species
T3527 24472-24477 NCBITaxon:10088 denotes mouse
T3526 24374-24380 PR:000036337 denotes Tas2rs
T3525 24343-24360 NCBITaxon:9527 denotes old world monkeys
T3524 24328-24338 NCBITaxon:9604 denotes great apes
T3523 24320-24326 NCBITaxon:9606 denotes humans
T3522 24310-24316 PR:000036337 denotes Tas2rs
T3521 24227-24238 SO:0000855 denotes orthologues
T3520 24191-24204 SO:0001816 denotes nonsynonymous
T3519 23992-23995 PR:000036337 denotes T2R
T3518 23906-23910 PR:000036337 denotes T2Rs
T3517 23780-23793 GO:0005576 denotes extracellular
T3516 23752-23758 PR:000036337 denotes Tas2rs
T3515 23620-23627 SO:0000417 denotes domains
T3514 23516-23522 PR:000036337 denotes Tas2rs
T3513 23448-23461 CHEBI:27641 denotes cyclohexamide
T3512 23424-23433 CHEBI:36357 denotes compounds
T3511 23398-23403 GO:0050909 denotes taste
T3510 23351-23355 NCBITaxon:10088 denotes mice
T3509 23298-23304 PR:000036337 denotes Tas2rs
T3508 23211-23217 PR:000036337 denotes Tas2rs
T3507 23157-23162 GO:0050909 denotes taste
T3506 23149-23156 CHEBI:15854 denotes quinine
T3505 23141-23144 SO:0000771 denotes QTL
T3504 23057-23061 CHEBI:8502 denotes PROP
T3503 23049-23052 SO:0000771 denotes QTL
T3502 22993-22996 PR:000036337 denotes T2R
T3501 22956-22975 CHEBI:62488 denotes signaling molecules
T3500 22930-22935 SO:0000704 denotes genes
T3499 22876-22883 SO:0000704 denotes genetic
T3498 22851-22863 GO:0050913 denotes bitter taste
T3497 22835-22845 SO:0000854 denotes paralogues
T3496 22797-22802 GO:0050909 denotes taste
T2566 17991-18000 SO:0001024 denotes haplotype
T2565 17965-17970 PR:000036337 denotes Tas2r
T2564 17906-17911 GO:0050909 denotes taste
T2563 17869-17873 SO:0000704 denotes gene
T2562 17863-17868 PR:000036337 denotes Tas2r
T2561 17737-17742 PR:000036337 denotes Tas2r
T2560 17536-17540 SO:0000704 denotes gene
T2559 17481-17492 SO:0000006 denotes PCR product
T2558 17458-17462 NCBITaxon:10088 denotes mice
T2557 17418-17426 PR:000016902 denotes Tas2r120
T2556 17338-17346 PR:000016896 denotes Tas2r110
T2555 17325-17333 PR:000016898 denotes Tas2r114
T2554 17315-17323 PR:000016891 denotes Tas2r104
T2553 17308-17313 SO:0000704 denotes genes
T2552 17275-17281 SO:0001023 denotes allele
T2551 17233-17244 SO:0000006 denotes PCR product
T2550 17227-17232 PR:000036337 denotes Tas2r
T2549 17058-17065 SO:0001023 denotes alleles
T2548 17052-17057 PR:000036337 denotes Tas2r
T2547 17029-17034 GO:0050909 denotes taste
T2546 16948-16955 SO:0001026 denotes genomic
T2545 16895-16900 GO:0050909 denotes taste
T2544 16862-16869 SO:0001023 denotes alleles
T2543 16856-16861 PR:000036337 denotes Tas2r
T2542 16831-16834 SO:0000771 denotes QTL
T2541 16825-16830 GO:0050909 denotes taste
T2540 16693-16704 SO:0000858 denotes orthologous
T2539 16669-16670 PR:000036337 denotes T
T2538 16136-16140 PR:000036337 denotes T2Rs
T2537 16109-16122 GO:0005576 denotes extracellular
T2536 15999-16005 PR:000036337 denotes Tas2rs
T2535 15920-15932 SO:0000195 denotes coding exons
T2534 15869-15900 SO:0000694 denotes single nucleotide polymorphisms
T2533 15855-15859 NCBITaxon:10088 denotes mice
T2532 15834-15841 SO:0001023 denotes alleles
T2531 15803-15809 PR:000036337 denotes Tas2rs
T2530 15740-15746 PR:000036337 denotes Tas2rs
T1877 12825-12828 SO:0000771 denotes QTL
T1876 12807-12812 GO:0050909 denotes taste
T1875 12750-12756 PR:000036337 denotes Tas2rs
T1874 12696-12705 CHEBI:36357 denotes compounds
T1873 12681-12695 GO:0050913 denotes bitter-tasting
T1872 12610-12630 CL:0000209 denotes taste receptor cells
T1871 12610-12615 GO:0050909 denotes taste
T1870 12596-12606 GO:0010467 denotes expression
T1869 12429-12433 PR:000036337 denotes T2Rs
T1868 12405-12410 SO:0000704 denotes genes
T1867 12399-12404 PR:000036337 denotes Tas2r
T1866 12378-12383 GO:0050909 denotes taste
T1865 12369-12393 PR:000036337 denotes T2R-type taste receptors
T1864 12322-12341 CL:0000623 denotes natural killer cell
T1863 12244-12249 SO:0000704 denotes genes
T1862 12169-12172 SO:0000771 denotes QTL
T1861 12094-12100 SO:0001026 denotes genome
T1860 11776-11781 NCBITaxon:10088 denotes mouse
T1859 11714-11717 SO:0000771 denotes QTL
T1858 11693-11696 SO:0000771 denotes QTL
T1857 11554-11559 GO:0050909 denotes taste
T1856 11511-11515 NCBITaxon:10088 denotes mice
T1855 11109-11112 SO:0000771 denotes QTL
T1854 10978-10979 GO:0050909 denotes s
T1853 10972-10975 SO:0000771 denotes QTL
T1852 10955-10956 SO:0000771 denotes T
T1851 10563-10569 SO:0001026 denotes genome
T1850 10512-10515 SO:0000771 denotes QTL
T1849 10451-10454 SO:0000771 denotes QTL
T1848 10429-10435 SO:0001026 denotes genome
T1847 10326-10329 SO:0000771 denotes QTL
T1846 10304-10310 SO:0001026 denotes genome
T1845 10231-10237 SO:0001026 denotes genome
T1844 10113-10118 GO:0050909 denotes taste
T1843 10085-10089 SO:0000771 denotes QTLs
T1842 9985-9988 SO:0000771 denotes QTL
T2520 15251-15259 PR:000016904 denotes Tas2r124
T2519 15238-15246 PR:000016893 denotes Tas2r106
T2518 15220-15227 SO:0001023 denotes alleles
T2517 15214-15219 PR:000036337 denotes Tas2r
T2516 15160-15171 SO:0000855 denotes orthologues
T2515 15095-15102 SO:0000440 denotes vectors
T2514 15054-15066 SO:0000006 denotes PCR products
T2513 15041-15048 SO:0001026 denotes genomic
T2512 15011-15016 PR:000036337 denotes Tas2r
T2511 14942-14947 PR:000036337 denotes Tas2r
T2510 14898-14906 SO:0000357 denotes flanking
T2509 14825-14829 NCBITaxon:10088 denotes mice
T2508 14750-14761 SO:0000336 denotes pseudogenes
T2507 14744-14749 PR:000036337 denotes Tas2r
T2506 14710-14716 PR:000036337 denotes Tas2rs
T2505 14660-14665 GO:0050909 denotes taste
T2504 14624-14629 PR:000036337 denotes Tas2r
T2503 14415-14425 GO:0010467 denotes expression
T2502 14400-14406 SO:0001023 denotes allele
T2501 14394-14399 PR:000036337 denotes Tas2r
T2500 14367-14385 SO:0005836 denotes regulatory regions
T2499 14367-14377 GO:0065007 denotes regulatory
T2498 14227-14233 SO:0001023 denotes allele
T2497 14221-14226 PR:000036337 denotes Tas2r
T2496 14201-14212 SO:0000195 denotes coding exon
T2495 14158-14162 NCBITaxon:10088 denotes mice
T2494 14076-14086 SO:0000336 denotes pseudogene
T2493 14064-14070 SO:0001023 denotes allele
T2492 14058-14063 PR:000036337 denotes Tas2r
T2491 13995-14000 SO:0000704 denotes genes
T2490 13989-13994 PR:000036337 denotes Tas2r
T2489 13948-13951 SO:0000771 denotes QTL
T2488 13930-13935 GO:0050909 denotes taste
T2487 13892-13898 PR:000036337 denotes Tas2rs
T2486 13867-13874 SO:0001023 denotes alleles
T2485 13863-13866 PR:000036337 denotes T2R
T1499 9818-9823 GO:0050909 denotes taste
T1498 9694-9698 NCBITaxon:10088 denotes mice
T1497 9647-9651 NCBITaxon:10088 denotes mice
T16 374-394 CL:0000209 denotes taste receptor cells
T17 402-408 UBERON:0001723 denotes tongue
T18 559-566 CHEBI:15854 denotes quinine
T19 567-580 CHEBI:17883 denotes hydrochloride
T20 603-611 CHEBI:16150 denotes benzoate
T21 659-664 GO:0050909 denotes taste
T22 707-712 NCBITaxon:10088 denotes mouse
T23 738-762 SO:0000771 denotes quantitative trait locus
T24 764-767 SO:0000771 denotes QTL
T25 773-778 GO:0050909 denotes taste
T26 805-808 SO:0000771 denotes QTL
T27 876-881 SO:0000704 denotes genes
T28 891-895 PR:000036337 denotes T2Rs
T29 897-903 PR:000036337 denotes Tas2rs
T30 906-912 PR:000036337 denotes Tas2rs
T31 962-993 SO:0000694 denotes single nucleotide polymorphisms
T32 995-999 SO:0000694 denotes SNPs
T33 1055-1062 CHEBI:15854 denotes quinine
T34 1086-1093 CHEBI:15854 denotes quinine
T35 1223-1228 PR:000036337 denotes Tas2r
T36 1229-1236 SO:0001023 denotes alleles
T37 1285-1290 PR:000036337 denotes Tas2r
T38 1291-1298 SO:0001023 denotes alleles
T39 1359-1366 SO:0001023 denotes alleles
T40 1385-1390 PR:000036337 denotes Tas2r
T41 1417-1426 SO:0001024 denotes haplotype
T42 1448-1455 CHEBI:15854 denotes quinine
T43 1516-1521 GO:0050909 denotes taste
T44 1553-1556 SO:0000771 denotes QTL
T45 1561-1568 CHEBI:15854 denotes quinine
T46 1569-1574 GO:0050909 denotes taste
T47 1592-1595 PR:000036337 denotes T2R
T48 1681-1688 CHEBI:15854 denotes quinine
T49 1689-1694 GO:0050909 denotes taste
T50 1762-1774 SO:0000195 denotes coding exons
T51 1782-1787 PR:000036337 denotes Tas2r
T52 1863-1875 GO:0050913 denotes bitter taste
T53 1901-1904 PR:000036337 denotes T2R
T503 2063-2068 CHEBI:33290 denotes foods
T504 2126-2140 GO:0050913 denotes bitter-tasting
T505 2141-2146 CHEBI:33290 denotes foods
T506 2258-2267 GO:0010467 denotes expressed
T507 2289-2294 GO:0050909 denotes taste
T508 2289-2309 CL:0000209 denotes taste receptor cells
T509 2311-2315 CL:0000209 denotes TRCs
T510 2324-2333 GO:0050909 denotes gustatory
T511 2324-2344 UBERON:0002926 denotes gustatory epithelium
T512 2373-2402 _FRAGMENT denotes detection and transduction of
T513 2410-2416 _FRAGMENT denotes bitter
T514 2445-2450 GO:0001580 denotes taste
T515 2421-2426 _FRAGMENT denotes umami
T516 2445-2450 GO:0046535 denotes taste
T517 2373-2408 _FRAGMENT denotes detection and transduction of sweet
T518 2445-2450 GO:0001582 denotes taste
T519 2452-2456 PR:000036336 denotes T1Rs
T520 2461-2467 _FRAGMENT denotes sweet-
T521 2477-2484 GO:0050916 denotes tasting
T522 2471-2484 GO:0050917 denotes umami-tasting
T523 2504-2508 PR:000036337 denotes T2Rs
T524 2513-2527 GO:0050913 denotes bitter-tasting
T525 2528-2537 CHEBI:36357 denotes compounds
T526 2550-2555 SO:0000704 denotes genes
T527 2568-2572 PR:000036337 denotes T2Rs
T528 2578-2584 PR:000036337 denotes Tas2rs
T529 2630-2639 NCBITaxon:40674 denotes mammalian
T530 2640-2647 SO:0001026 denotes genomes
T531 2709-2721 GO:0050913 denotes bitter taste
T532 2748-2752 NCBITaxon:10088 denotes mice
T533 2770-2776 PR:000036337 denotes Tas2rs
T534 2842-2847 NCBITaxon:9606 denotes human
T535 2848-2854 PR:000036337 denotes Tas2rs
T536 2868-2879 SO:0000336 denotes pseudogenes
T537 2896-2901 NCBITaxon:10088 denotes mouse
T538 2902-2908 PR:000036337 denotes Tas2rs
T539 2922-2933 SO:0000336 denotes pseudogenes
T540 2946-2950 NCBITaxon:10088 denotes mice
T541 3058-3068 GO:0010467 denotes expression
T542 3120-3124 SO:0000704 denotes gene
T543 3140-3152 GO:0050913 denotes bitter taste
T544 3192-3215 SO:0000771 denotes quantitative trait loci
T545 3217-3220 SO:0000771 denotes QTL
T546 3269-3275 GO:0007631 denotes intake
T547 3301-3306 NCBITaxon:10088 denotes mouse
T548 3327-3334 CHEBI:15854 denotes quinine
T549 3336-3339 CHEBI:15854 denotes Qui
T550 3353-3366 CHEBI:27641 denotes cyclohexamide
T551 3368-3371 CHEBI:27641 denotes Cyx
T552 3446-3449 SO:0000771 denotes QTL
T553 3457-3462 NCBITaxon:10088 denotes mouse
T554 3562-3568 PR:000036337 denotes Tas2rs
T555 3584-3590 SO:0001026 denotes genome
T556 3883-3886 SO:0000771 denotes QTL
T557 3927-3939 GO:0050913 denotes bitter taste
T558 3940-3944 SO:0000771 denotes QTLs
T559 3987-3998 GO:0007631 denotes consumption
T560 4051-4060 GO:0007631 denotes ingestive
T561 4164-4176 GO:0050913 denotes bitter taste
T562 4260-4264 SO:0000771 denotes QTLs
T563 4268-4280 GO:0050913 denotes bitter taste
T564 4389-4400 CHEBI:59941 denotes amphiphilic
T565 4408-4417 CHEBI:36357 denotes compounds
T566 4427-4434 CHEBI:15854 denotes quinine
T567 4450-4458 CHEBI:16150 denotes benzoate
T568 4474-4479 GO:0050909 denotes taste
T569 4474-4494 CL:0000209 denotes taste receptor cells
T570 4531-4538 CHEBI:15854 denotes Quinine
T571 4582-4589 CHEBI:15854 denotes quinine
T572 4615-4617 CHEBI:29103 denotes K+
T573 4637-4645 CHEBI:27732 denotes caffeine
T574 4655-4669 GO:0050913 denotes bitter-tasting
T575 4699-4712 GO:0005622 denotes intracellular
T576 4776-4779 PR:000036337 denotes T2R
T577 4794-4797 PR:000036337 denotes T2R
T578 4889-4894 GO:0050909 denotes taste
T579 4945-4950 GO:0050909 denotes taste
T580 5036-5040 NCBITaxon:10088 denotes mice
T581 5064-5071 CHEBI:15854 denotes quinine
T582 5072-5085 CHEBI:17883 denotes hydrochloride
T583 5108-5116 CHEBI:16150 denotes benzoate
T584 5220-5223 SO:0000771 denotes QTL
T585 5233-5238 GO:0050909 denotes taste
T586 5310-5315 PR:000036337 denotes Tas2r
T587 5316-5321 SO:0000704 denotes genes
T588 5378-5383 PR:000036337 denotes Tas2r
T589 5384-5390 SO:0001023 denotes allele
T590 5479-5484 SO:0000704 denotes genes
T591 5544-5550 PR:000036337 denotes Tas2rs
T592 5569-5578 SO:0001024 denotes haplotype
T593 5605-5610 GO:0050909 denotes taste
T1481 5634-5639 GO:0050909 denotes Taste
T1482 5672-5675 SO:0000771 denotes QTL
T1483 5680-5692 GO:0050913 denotes bitter taste
T1484 5707-5718 GO:0007631 denotes consumption
T1485 5777-5786 GO:0007631 denotes ingestive
T1486 5932-5936 NCBITaxon:10088 denotes mice
T1487 5960-5965 GO:0050909 denotes taste
T1488 5985-5990 GO:0050909 denotes taste
T1489 6048-6052 NCBITaxon:10088 denotes mice
T1490 6181-6189 CHEBI:36357 denotes compound
T1491 6243-6248 GO:0050909 denotes taste
T1492 6390-6394 NCBITaxon:10088 denotes mice
T1493 6493-6502 CHEBI:36357 denotes compounds
T1494 6625-6629 NCBITaxon:10088 denotes mice
T1495 6674-6678 NCBITaxon:10088 denotes mice
T1496 6766-6771 GO:0050909 denotes taste
T3495 22793-22796 CHEBI:46261 denotes PTC
T7342 6893-6897 NCBITaxon:10088 denotes mice
T499 1976-1985 GO:0050909 denotes gustatory
T500 1976-1992 UBERON:0001033 denotes gustatory system
T501 2022-2026 CHEBI:33290 denotes food
T502 2049-2062 GO:0050916 denotes sweet-tasting
T1 0-10 SO:0001024 denotes Haplotypes
T2 18-23 PR:000036337 denotes Tas2r
T3 63-70 CHEBI:15854 denotes quinine
T4 71-76 GO:0050909 denotes taste
T5 99-103 NCBITaxon:10088 denotes mice
T6 142-156 GO:0050913 denotes bitter-tasting
T7 157-166 CHEBI:36357 denotes compounds
T8 174-183 GO:0050909 denotes gustatory
T9 174-190 UBERON:0001033 denotes gustatory system
T10 211-218 NCBITaxon:33208 denotes animals
T11 256-260 CHEBI:33290 denotes food
T12 313-318 GO:0050909 denotes taste
T13 334-338 PR:000036337 denotes T2Rs
T14 350-359 GO:0010467 denotes expressed
T15 374-379 GO:0050909 denotes taste
T498 1960-1967 NCBITaxon:33208 denotes Animals
T2529 15695-15706 SO:0000336 denotes pseudogenes
T2528 15682-15687 SO:0000704 denotes genes
T2527 15552-15560 PR:000016900 denotes Tas2r117
T2526 15539-15547 PR:000016890 denotes Tas2r103
T2525 15530-15537 SO:0001023 denotes alleles
T2524 15517-15521 NCBITaxon:10088 denotes mice
T2523 15494-15499 PR:000036337 denotes Tas2r
T2522 15383-15390 SO:0001026 denotes genomic
T2521 15342-15350 PR:000016902 denotes Tas2r120
T3446 20502-20514 GO:0050913 denotes bitter taste
T3445 20425-20432 SO:0000704 denotes genetic
R346 T513 T512 _lexicallyChainedTo bitter,detection and transduction of
R347 T514 T513 _lexicallyChainedTo taste,bitter
R348 T515 T512 _lexicallyChainedTo umami,detection and transduction of
R349 T516 T515 _lexicallyChainedTo taste,umami
R350 T518 T517 _lexicallyChainedTo taste,detection and transduction of sweet
R351 T521 T520 _lexicallyChainedTo tasting,sweet-
R2526 T3486 T3485 _lexicallyChainedTo taste,sweet