PMC:1166548 / 22900-23418
Annnotations
craft-sa-dev
{"project":"craft-sa-dev","denotations":[{"id":"T5420","span":{"begin":508,"end":517},"obj":"NN"},{"id":"T5419","span":{"begin":502,"end":507},"obj":"NN"},{"id":"T5418","span":{"begin":490,"end":501},"obj":"VBG"},{"id":"T5417","span":{"begin":487,"end":489},"obj":"IN"},{"id":"T5416","span":{"begin":472,"end":481},"obj":"JJ"},{"id":"T5415","span":{"begin":482,"end":486},"obj":"NN"},{"id":"T5414","span":{"begin":469,"end":471},"obj":"DT"},{"id":"T5413","span":{"begin":462,"end":463},"obj":"-RRB-"},{"id":"T5412","span":{"begin":446,"end":448},"obj":","},{"id":"T5411","span":{"begin":437,"end":446},"obj":"NNS"},{"id":"T5410","span":{"begin":435,"end":437},"obj":","},{"id":"T5409","span":{"begin":448,"end":462},"obj":"NNS"},{"id":"T5408","span":{"begin":426,"end":435},"obj":"NN"},{"id":"T5407","span":{"begin":425,"end":426},"obj":"-LRB-"},{"id":"T5406","span":{"begin":413,"end":424},"obj":"NNS"},{"id":"T5405","span":{"begin":409,"end":412},"obj":"CC"},{"id":"T5404","span":{"begin":403,"end":408},"obj":"NNS"},{"id":"T5403","span":{"begin":398,"end":402},"obj":"NN"},{"id":"T5402","span":{"begin":395,"end":397},"obj":"IN"},{"id":"T5401","span":{"begin":386,"end":394},"obj":"VBN"},{"id":"T5400","span":{"begin":376,"end":385},"obj":"NNS"},{"id":"T5399","span":{"begin":367,"end":375},"obj":"NN"},{"id":"T5398","span":{"begin":464,"end":468},"obj":"VBP"},{"id":"T5397","span":{"begin":362,"end":366},"obj":"IN"},{"id":"T5396","span":{"begin":355,"end":361},"obj":"JJ"},{"id":"T5395","span":{"begin":352,"end":354},"obj":"VBZ"},{"id":"T5394","span":{"begin":349,"end":351},"obj":"PRP"},{"id":"T5393","span":{"begin":345,"end":348},"obj":"CC"},{"id":"T5392","span":{"begin":343,"end":345},"obj":","},{"id":"T5391","span":{"begin":342,"end":343},"obj":"-RRB-"},{"id":"T5390","span":{"begin":340,"end":342},"obj":"CD"},{"id":"T5389","span":{"begin":339,"end":340},"obj":"-LRB-"},{"id":"T5388","span":{"begin":336,"end":338},"obj":"NN"},{"id":"T5387","span":{"begin":333,"end":335},"obj":"IN"},{"id":"T5386","span":{"begin":327,"end":332},"obj":"NN"},{"id":"T5385","span":{"begin":324,"end":326},"obj":"IN"},{"id":"T5384","span":{"begin":309,"end":323},"obj":"NN"},{"id":"T5383","span":{"begin":305,"end":308},"obj":"IN"},{"id":"T5382","span":{"begin":296,"end":304},"obj":"NN"},{"id":"T5381","span":{"begin":291,"end":295},"obj":"RB"},{"id":"T5380","span":{"begin":282,"end":287},"obj":"EX"},{"id":"T5379","span":{"begin":280,"end":282},"obj":","},{"id":"T5378","span":{"begin":288,"end":290},"obj":"VBZ"},{"id":"T5377","span":{"begin":273,"end":280},"obj":"RB"},{"id":"T5376","span":{"begin":272,"end":518},"obj":"sentence"},{"id":"T5375","span":{"begin":271,"end":272},"obj":"."},{"id":"T5374","span":{"begin":265,"end":271},"obj":"NNS"},{"id":"T5373","span":{"begin":256,"end":264},"obj":"VBN"},{"id":"T5372","span":{"begin":253,"end":255},"obj":"IN"},{"id":"T5371","span":{"begin":246,"end":252},"obj":"NNS"},{"id":"T5370","span":{"begin":242,"end":245},"obj":"DT"},{"id":"T5369","span":{"begin":239,"end":241},"obj":"IN"},{"id":"T5340","span":{"begin":94,"end":96},"obj":"PRP"},{"id":"T5339","span":{"begin":93,"end":159},"obj":"sentence"},{"id":"T5338","span":{"begin":92,"end":93},"obj":"."},{"id":"T5337","span":{"begin":80,"end":82},"obj":"NN"},{"id":"T5336","span":{"begin":83,"end":92},"obj":"NN"},{"id":"T5335","span":{"begin":76,"end":79},"obj":"DT"},{"id":"T5334","span":{"begin":73,"end":75},"obj":"IN"},{"id":"T5333","span":{"begin":54,"end":59},"obj":"NN"},{"id":"T5332","span":{"begin":60,"end":72},"obj":"NN"},{"id":"T5331","span":{"begin":44,"end":53},"obj":"JJ"},{"id":"T5330","span":{"begin":41,"end":43},"obj":"IN"},{"id":"T5329","span":{"begin":29,"end":33},"obj":"RB"},{"id":"T5328","span":{"begin":25,"end":28},"obj":"MD"},{"id":"T5327","span":{"begin":34,"end":40},"obj":"VB"},{"id":"T5326","span":{"begin":8,"end":14},"obj":"JJ"},{"id":"T5325","span":{"begin":15,"end":24},"obj":"NNS"},{"id":"T5324","span":{"begin":0,"end":7},"obj":"VBN"},{"id":"T5368","span":{"begin":220,"end":226},"obj":"JJ"},{"id":"T5367","span":{"begin":215,"end":219},"obj":"RBR"},{"id":"T5366","span":{"begin":227,"end":238},"obj":"NN"},{"id":"T5365","span":{"begin":213,"end":214},"obj":"DT"},{"id":"T5364","span":{"begin":209,"end":212},"obj":"CC"},{"id":"T5363","span":{"begin":193,"end":198},"obj":"NN"},{"id":"T5362","span":{"begin":199,"end":208},"obj":"NN"},{"id":"T5361","span":{"begin":185,"end":192},"obj":"VBN"},{"id":"T5360","span":{"begin":182,"end":184},"obj":"IN"},{"id":"T5359","span":{"begin":178,"end":181},"obj":"IN"},{"id":"T5358","span":{"begin":171,"end":174},"obj":"MD"},{"id":"T5357","span":{"begin":168,"end":170},"obj":"PRP"},{"id":"T5356","span":{"begin":163,"end":167},"obj":"JJ"},{"id":"T5355","span":{"begin":175,"end":177},"obj":"VB"},{"id":"T5354","span":{"begin":160,"end":162},"obj":"IN"},{"id":"T5353","span":{"begin":159,"end":272},"obj":"sentence"},{"id":"T5352","span":{"begin":158,"end":159},"obj":"."},{"id":"T5351","span":{"begin":151,"end":158},"obj":"NNS"},{"id":"T5350","span":{"begin":148,"end":150},"obj":"NN"},{"id":"T5349","span":{"begin":145,"end":147},"obj":"IN"},{"id":"T5348","span":{"begin":138,"end":144},"obj":"NNS"},{"id":"T5347","span":{"begin":133,"end":137},"obj":"JJ"},{"id":"T5346","span":{"begin":130,"end":132},"obj":"IN"},{"id":"T5345","span":{"begin":112,"end":117},"obj":"NN"},{"id":"T5344","span":{"begin":118,"end":129},"obj":"VBZ"},{"id":"T5343","span":{"begin":108,"end":111},"obj":"WRB"},{"id":"T5342","span":{"begin":100,"end":107},"obj":"JJ"},{"id":"T5341","span":{"begin":97,"end":99},"obj":"VBZ"},{"id":"T5421","span":{"begin":517,"end":518},"obj":"."}],"relations":[{"id":"R3514","pred":"amod","subj":"T5324","obj":"T5325"},{"id":"R3515","pred":"nsubj","subj":"T5325","obj":"T5327"},{"id":"R3516","pred":"amod","subj":"T5326","obj":"T5325"},{"id":"R3517","pred":"aux","subj":"T5328","obj":"T5327"},{"id":"R3518","pred":"advmod","subj":"T5329","obj":"T5327"},{"id":"R3519","pred":"prep","subj":"T5330","obj":"T5327"},{"id":"R3520","pred":"amod","subj":"T5331","obj":"T5332"},{"id":"R3521","pred":"pobj","subj":"T5332","obj":"T5330"},{"id":"R3522","pred":"compound","subj":"T5333","obj":"T5332"},{"id":"R3523","pred":"prep","subj":"T5334","obj":"T5332"},{"id":"R3524","pred":"det","subj":"T5335","obj":"T5336"},{"id":"R3525","pred":"pobj","subj":"T5336","obj":"T5334"},{"id":"R3526","pred":"compound","subj":"T5337","obj":"T5336"},{"id":"R3527","pred":"punct","subj":"T5338","obj":"T5327"},{"id":"R3528","pred":"nsubj","subj":"T5340","obj":"T5341"},{"id":"R3529","pred":"acomp","subj":"T5342","obj":"T5341"},{"id":"R3530","pred":"advmod","subj":"T5343","obj":"T5344"},{"id":"R3531","pred":"ccomp","subj":"T5344","obj":"T5341"},{"id":"R3532","pred":"nsubj","subj":"T5345","obj":"T5344"},{"id":"R3533","pred":"prep","subj":"T5346","obj":"T5344"},{"id":"R3534","pred":"amod","subj":"T5347","obj":"T5348"},{"id":"R3535","pred":"pobj","subj":"T5348","obj":"T5346"},{"id":"R3536","pred":"prep","subj":"T5349","obj":"T5344"},{"id":"R3537","pred":"compound","subj":"T5350","obj":"T5351"},{"id":"R3538","pred":"pobj","subj":"T5351","obj":"T5349"},{"id":"R3539","pred":"punct","subj":"T5352","obj":"T5341"},{"id":"R3540","pred":"prep","subj":"T5354","obj":"T5355"},{"id":"R3541","pred":"amod","subj":"T5356","obj":"T5354"},{"id":"R3542","pred":"nsubj","subj":"T5357","obj":"T5355"},{"id":"R3543","pred":"aux","subj":"T5358","obj":"T5355"},{"id":"R3544","pred":"prep","subj":"T5359","obj":"T5355"},{"id":"R3545","pred":"pcomp","subj":"T5360","obj":"T5359"},{"id":"R3546","pred":"amod","subj":"T5361","obj":"T5362"},{"id":"R3547","pred":"pobj","subj":"T5362","obj":"T5359"},{"id":"R3548","pred":"compound","subj":"T5363","obj":"T5362"},{"id":"R3549","pred":"cc","subj":"T5364","obj":"T5362"},{"id":"R3550","pred":"det","subj":"T5365","obj":"T5366"},{"id":"R3551","pred":"conj","subj":"T5366","obj":"T5362"},{"id":"R3552","pred":"advmod","subj":"T5367","obj":"T5368"},{"id":"R3553","pred":"amod","subj":"T5368","obj":"T5366"},{"id":"R3554","pred":"prep","subj":"T5369","obj":"T5366"},{"id":"R3555","pred":"det","subj":"T5370","obj":"T5371"},{"id":"R3556","pred":"pobj","subj":"T5371","obj":"T5369"},{"id":"R3557","pred":"prep","subj":"T5372","obj":"T5371"},{"id":"R3558","pred":"amod","subj":"T5373","obj":"T5374"},{"id":"R3559","pred":"pobj","subj":"T5374","obj":"T5372"},{"id":"R3560","pred":"punct","subj":"T5375","obj":"T5355"},{"id":"R3561","pred":"advmod","subj":"T5377","obj":"T5378"},{"id":"R3562","pred":"punct","subj":"T5379","obj":"T5378"},{"id":"R3563","pred":"expl","subj":"T5380","obj":"T5378"},{"id":"R3564","pred":"advmod","subj":"T5381","obj":"T5378"},{"id":"R3565","pred":"attr","subj":"T5382","obj":"T5378"},{"id":"R3566","pred":"prep","subj":"T5383","obj":"T5382"},{"id":"R3567","pred":"pobj","subj":"T5384","obj":"T5383"},{"id":"R3568","pred":"prep","subj":"T5385","obj":"T5384"},{"id":"R3569","pred":"pobj","subj":"T5386","obj":"T5385"},{"id":"R3570","pred":"prep","subj":"T5387","obj":"T5384"},{"id":"R3571","pred":"pobj","subj":"T5388","obj":"T5387"},{"id":"R3572","pred":"punct","subj":"T5389","obj":"T5390"},{"id":"R3573","pred":"parataxis","subj":"T5390","obj":"T5378"},{"id":"R3574","pred":"punct","subj":"T5391","obj":"T5390"},{"id":"R3575","pred":"punct","subj":"T5392","obj":"T5378"},{"id":"R3576","pred":"cc","subj":"T5393","obj":"T5378"},{"id":"R3577","pred":"nsubj","subj":"T5394","obj":"T5395"},{"id":"R3578","pred":"conj","subj":"T5395","obj":"T5378"},{"id":"R3579","pred":"acomp","subj":"T5396","obj":"T5395"},{"id":"R3580","pred":"mark","subj":"T5397","obj":"T5398"},{"id":"R3581","pred":"ccomp","subj":"T5398","obj":"T5395"},{"id":"R3582","pred":"compound","subj":"T5399","obj":"T5400"},{"id":"R3583","pred":"nsubj","subj":"T5400","obj":"T5398"},{"id":"R3584","pred":"acl","subj":"T5401","obj":"T5400"},{"id":"R3585","pred":"agent","subj":"T5402","obj":"T5401"},{"id":"R3586","pred":"compound","subj":"T5403","obj":"T5404"},{"id":"R3587","pred":"pobj","subj":"T5404","obj":"T5402"},{"id":"R3588","pred":"cc","subj":"T5405","obj":"T5404"},{"id":"R3589","pred":"conj","subj":"T5406","obj":"T5404"},{"id":"R3590","pred":"punct","subj":"T5407","obj":"T5406"},{"id":"R3591","pred":"nmod","subj":"T5408","obj":"T5409"},{"id":"R3592","pred":"appos","subj":"T5409","obj":"T5406"},{"id":"R3593","pred":"punct","subj":"T5410","obj":"T5409"},{"id":"R3594","pred":"nmod","subj":"T5411","obj":"T5409"},{"id":"R3595","pred":"punct","subj":"T5412","obj":"T5409"},{"id":"R3596","pred":"punct","subj":"T5413","obj":"T5406"},{"id":"R3597","pred":"det","subj":"T5414","obj":"T5415"},{"id":"R3598","pred":"dobj","subj":"T5415","obj":"T5398"},{"id":"R3599","pred":"amod","subj":"T5416","obj":"T5415"},{"id":"R3600","pred":"prep","subj":"T5417","obj":"T5415"},{"id":"R3601","pred":"pcomp","subj":"T5418","obj":"T5417"},{"id":"R3602","pred":"compound","subj":"T5419","obj":"T5420"},{"id":"R3603","pred":"dobj","subj":"T5420","obj":"T5418"},{"id":"R3604","pred":"punct","subj":"T5421","obj":"T5395"}],"text":"Altered immune responses may also relate to excessive mucus accumulation in the CF intestine. It is unclear why mucus accumulates to high levels in CF tissues. In part it may be due to reduced fluid secretion and a more acidic environment in the lumina of affected organs. However, there is also evidence for hypersecretion of mucus in CF [12], and it is likely that effector molecules released by mast cells and neutrophils (histamine, proteases, prostaglandins) have an important role in stimulating mucus secretion."}
craft-ca-core-ex-dev
{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T4291","span":{"begin":508,"end":517},"obj":"GO_EXT:secretion_entity_or_process"},{"id":"T4290","span":{"begin":502,"end":507},"obj":"UBERON:0000912"},{"id":"T4289","span":{"begin":448,"end":462},"obj":"CHEBI:26333"},{"id":"T4288","span":{"begin":437,"end":446},"obj":"GO_EXT:0008233"},{"id":"T4287","span":{"begin":426,"end":435},"obj":"CHEBI:18295"},{"id":"T4286","span":{"begin":413,"end":424},"obj":"CL:0000775"},{"id":"T4285","span":{"begin":403,"end":408},"obj":"CL_GO_EXT:cell"},{"id":"T4284","span":{"begin":398,"end":408},"obj":"CL:0000097"},{"id":"T4283","span":{"begin":386,"end":394},"obj":"GO_EXT:biological_release"},{"id":"T4282","span":{"begin":376,"end":385},"obj":"CHEBI:36357"},{"id":"T4281","span":{"begin":367,"end":375},"obj":"CHEBI_EXT:35224"},{"id":"T4280","span":{"begin":327,"end":332},"obj":"UBERON:0000912"},{"id":"T4279","span":{"begin":314,"end":323},"obj":"GO_EXT:secretion_entity_or_process"},{"id":"T4278","span":{"begin":265,"end":271},"obj":"UBERON:0000062"},{"id":"T4277","span":{"begin":246,"end":252},"obj":"GO_UBERON_EXT:lumen"},{"id":"T4276","span":{"begin":220,"end":226},"obj":"CHEBI_EXT:37527"},{"id":"T4275","span":{"begin":199,"end":208},"obj":"GO_EXT:secretion_entity_or_process"},{"id":"T4274","span":{"begin":193,"end":198},"obj":"UBERON:0006314"},{"id":"T4273","span":{"begin":151,"end":158},"obj":"UBERON:0000479"},{"id":"T4272","span":{"begin":112,"end":117},"obj":"UBERON:0000912"},{"id":"T4271","span":{"begin":83,"end":92},"obj":"UBERON:0000160"},{"id":"T4270","span":{"begin":54,"end":59},"obj":"UBERON:0000912"},{"id":"T4269","span":{"begin":8,"end":24},"obj":"GO:0006955"},{"id":"T4268","span":{"begin":8,"end":14},"obj":"UBERON:0002405"}],"text":"Altered immune responses may also relate to excessive mucus accumulation in the CF intestine. It is unclear why mucus accumulates to high levels in CF tissues. In part it may be due to reduced fluid secretion and a more acidic environment in the lumina of affected organs. However, there is also evidence for hypersecretion of mucus in CF [12], and it is likely that effector molecules released by mast cells and neutrophils (histamine, proteases, prostaglandins) have an important role in stimulating mucus secretion."}
craft-ca-core-dev
{"project":"craft-ca-core-dev","denotations":[{"id":"T4057","span":{"begin":502,"end":507},"obj":"UBERON:0000912"},{"id":"T4056","span":{"begin":448,"end":462},"obj":"CHEBI:26333"},{"id":"T4055","span":{"begin":426,"end":435},"obj":"CHEBI:18295"},{"id":"T4054","span":{"begin":413,"end":424},"obj":"CL:0000775"},{"id":"T4053","span":{"begin":398,"end":408},"obj":"CL:0000097"},{"id":"T4052","span":{"begin":376,"end":385},"obj":"CHEBI:36357"},{"id":"T4051","span":{"begin":367,"end":375},"obj":"CHEBI:35224"},{"id":"T4050","span":{"begin":327,"end":332},"obj":"UBERON:0000912"},{"id":"T4049","span":{"begin":265,"end":271},"obj":"UBERON:0000062"},{"id":"T4048","span":{"begin":220,"end":226},"obj":"CHEBI:37527"},{"id":"T4047","span":{"begin":193,"end":198},"obj":"UBERON:0006314"},{"id":"T4046","span":{"begin":151,"end":158},"obj":"UBERON:0000479"},{"id":"T4045","span":{"begin":112,"end":117},"obj":"UBERON:0000912"},{"id":"T4044","span":{"begin":83,"end":92},"obj":"UBERON:0000160"},{"id":"T4043","span":{"begin":54,"end":59},"obj":"UBERON:0000912"},{"id":"T4042","span":{"begin":8,"end":24},"obj":"GO:0006955"},{"id":"T4041","span":{"begin":8,"end":14},"obj":"UBERON:0002405"}],"text":"Altered immune responses may also relate to excessive mucus accumulation in the CF intestine. It is unclear why mucus accumulates to high levels in CF tissues. In part it may be due to reduced fluid secretion and a more acidic environment in the lumina of affected organs. However, there is also evidence for hypersecretion of mucus in CF [12], and it is likely that effector molecules released by mast cells and neutrophils (histamine, proteases, prostaglandins) have an important role in stimulating mucus secretion."}