PMC:1166548 / 17530-18187 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T4431","span":{"begin":652,"end":653},"obj":"-LRB-"},{"id":"T4430","span":{"begin":649,"end":651},"obj":"NN"},{"id":"T4429","span":{"begin":645,"end":648},"obj":"CD"},{"id":"T4428","span":{"begin":643,"end":645},"obj":","},{"id":"T4427","span":{"begin":638,"end":643},"obj":"NN"},{"id":"T4426","span":{"begin":635,"end":637},"obj":"IN"},{"id":"T4425","span":{"begin":632,"end":634},"obj":"VBZ"},{"id":"T4424","span":{"begin":626,"end":631},"obj":"WDT"},{"id":"T4423","span":{"begin":616,"end":620},"obj":"NN"},{"id":"T4422","span":{"begin":607,"end":615},"obj":"VBN"},{"id":"T4421","span":{"begin":621,"end":625},"obj":"NN"},{"id":"T4420","span":{"begin":603,"end":606},"obj":"DT"},{"id":"T4419","span":{"begin":600,"end":602},"obj":"IN"},{"id":"T4418","span":{"begin":596,"end":599},"obj":"IN"},{"id":"T4417","span":{"begin":587,"end":595},"obj":"RB"},{"id":"T4416","span":{"begin":584,"end":586},"obj":"VBZ"},{"id":"T4415","span":{"begin":578,"end":583},"obj":"WDT"},{"id":"T4414","span":{"begin":575,"end":577},"obj":"NN"},{"id":"T4413","span":{"begin":573,"end":574},"obj":"CD"},{"id":"T4412","span":{"begin":571,"end":573},"obj":","},{"id":"T4411","span":{"begin":570,"end":571},"obj":"CD"},{"id":"T4410","span":{"begin":559,"end":569},"obj":"NN"},{"id":"T4409","span":{"begin":556,"end":558},"obj":"IN"},{"id":"T4408","span":{"begin":544,"end":547},"obj":"CD"},{"id":"T4407","span":{"begin":540,"end":543},"obj":"CC"},{"id":"T4406","span":{"begin":548,"end":555},"obj":"NNS"},{"id":"T4405","span":{"begin":537,"end":539},"obj":"NN"},{"id":"T4404","span":{"begin":532,"end":536},"obj":"CC"},{"id":"T4403","span":{"begin":528,"end":531},"obj":"VBD"},{"id":"T4402","span":{"begin":516,"end":522},"obj":"CD"},{"id":"T4401","span":{"begin":523,"end":527},"obj":"NNS"},{"id":"T4400","span":{"begin":512,"end":515},"obj":"DT"},{"id":"T4399","span":{"begin":511,"end":657},"obj":"sentence"},{"id":"T4398","span":{"begin":510,"end":511},"obj":"."},{"id":"T4397","span":{"begin":508,"end":510},"obj":"NN"},{"id":"T4396","span":{"begin":505,"end":507},"obj":"CD"},{"id":"T4395","span":{"begin":503,"end":505},"obj":","},{"id":"T4394","span":{"begin":498,"end":503},"obj":"NN"},{"id":"T4393","span":{"begin":495,"end":497},"obj":"IN"},{"id":"T4392","span":{"begin":487,"end":494},"obj":"NNS"},{"id":"T4391","span":{"begin":482,"end":486},"obj":"DT"},{"id":"T4390","span":{"begin":477,"end":481},"obj":"IN"},{"id":"T4389","span":{"begin":469,"end":476},"obj":"NNS"},{"id":"T4388","span":{"begin":453,"end":459},"obj":"CD"},{"id":"T4387","span":{"begin":460,"end":464},"obj":"NNS"},{"id":"T4386","span":{"begin":449,"end":452},"obj":"DT"},{"id":"T4385","span":{"begin":446,"end":448},"obj":"IN"},{"id":"T4384","span":{"begin":465,"end":468},"obj":"VBD"},{"id":"T4383","span":{"begin":442,"end":445},"obj":"CD"},{"id":"T4382","span":{"begin":441,"end":511},"obj":"sentence"},{"id":"T4381","span":{"begin":440,"end":441},"obj":"."},{"id":"T4380","span":{"begin":430,"end":432},"obj":"NN"},{"id":"T4379","span":{"begin":433,"end":440},"obj":"NNS"},{"id":"T4378","span":{"begin":428,"end":429},"obj":"NN"},{"id":"T4377","span":{"begin":424,"end":428},"obj":"CD"},{"id":"T4376","span":{"begin":401,"end":403},"obj":"NN"},{"id":"T4375","span":{"begin":404,"end":414},"obj":"NN"},{"id":"T4374","span":{"begin":397,"end":400},"obj":"DT"},{"id":"T4373","span":{"begin":394,"end":396},"obj":"IN"},{"id":"T4372","span":{"begin":415,"end":423},"obj":"VBD"},{"id":"T4371","span":{"begin":386,"end":388},"obj":"NN"},{"id":"T4370","span":{"begin":389,"end":393},"obj":"NNS"},{"id":"T4369","span":{"begin":379,"end":385},"obj":"CD"},{"id":"T4368","span":{"begin":378,"end":441},"obj":"sentence"},{"id":"T4367","span":{"begin":377,"end":378},"obj":"."},{"id":"T4366","span":{"begin":375,"end":377},"obj":"NN"},{"id":"T4365","span":{"begin":366,"end":374},"obj":"JJ"},{"id":"T4364","span":{"begin":362,"end":365},"obj":"VBP"},{"id":"T4363","span":{"begin":357,"end":361},"obj":"PRP"},{"id":"T4362","span":{"begin":349,"end":356},"obj":"VB"},{"id":"T4361","span":{"begin":346,"end":348},"obj":"TO"},{"id":"T4360","span":{"begin":332,"end":336},"obj":"RB"},{"id":"T4359","span":{"begin":327,"end":331},"obj":"VBD"},{"id":"T4358","span":{"begin":325,"end":327},"obj":","},{"id":"T4357","span":{"begin":309,"end":314},"obj":"JJ"},{"id":"T4356","span":{"begin":305,"end":308},"obj":"CD"},{"id":"T4355","span":{"begin":304,"end":305},"obj":"HYPH"},{"id":"T4354","span":{"begin":302,"end":304},"obj":"NN"},{"id":"T4353","span":{"begin":315,"end":325},"obj":"NN"},{"id":"T4352","span":{"begin":300,"end":301},"obj":"DT"},{"id":"T4351","span":{"begin":297,"end":299},"obj":"IN"},{"id":"T4350","span":{"begin":286,"end":296},"obj":"RB"},{"id":"T4349","span":{"begin":281,"end":285},"obj":"NNS"},{"id":"T4348","span":{"begin":276,"end":280},"obj":"IN"},{"id":"T4347","span":{"begin":263,"end":267},"obj":"VBD"},{"id":"T4346","span":{"begin":268,"end":275},"obj":"VBN"},{"id":"T4345","span":{"begin":257,"end":262},"obj":"WDT"},{"id":"T4344","span":{"begin":255,"end":257},"obj":","},{"id":"T4343","span":{"begin":242,"end":244},"obj":"NN"},{"id":"T4342","span":{"begin":245,"end":255},"obj":"NN"},{"id":"T4341","span":{"begin":238,"end":241},"obj":"DT"},{"id":"T4340","span":{"begin":235,"end":237},"obj":"IN"},{"id":"T4339","span":{"begin":226,"end":234},"obj":"JJ"},{"id":"T4338","span":{"begin":337,"end":345},"obj":"VBN"},{"id":"T4337","span":{"begin":221,"end":225},"obj":"NNS"},{"id":"T4336","span":{"begin":220,"end":378},"obj":"sentence"},{"id":"T4335","span":{"begin":219,"end":220},"obj":"."},{"id":"T4334","span":{"begin":206,"end":211},"obj":"NN"},{"id":"T4333","span":{"begin":202,"end":205},"obj":"CD"},{"id":"T4332","span":{"begin":212,"end":219},"obj":"NNS"},{"id":"T4331","span":{"begin":196,"end":201},"obj":"DT"},{"id":"T4330","span":{"begin":188,"end":195},"obj":"IN"},{"id":"T4329","span":{"begin":174,"end":187},"obj":"NNS"},{"id":"T4328","span":{"begin":171,"end":173},"obj":"IN"},{"id":"T4327","span":{"begin":163,"end":170},"obj":"NNS"},{"id":"T4326","span":{"begin":159,"end":162},"obj":"IN"},{"id":"T4325","span":{"begin":155,"end":158},"obj":"NN"},{"id":"T4324","span":{"begin":152,"end":154},"obj":"IN"},{"id":"T4323","span":{"begin":139,"end":142},"obj":"VBD"},{"id":"T4322","span":{"begin":135,"end":138},"obj":"NN"},{"id":"T4321","span":{"begin":130,"end":134},"obj":"NN"},{"id":"T4320","span":{"begin":128,"end":130},"obj":","},{"id":"T4319","span":{"begin":112,"end":120},"obj":"NN"},{"id":"T4318","span":{"begin":121,"end":128},"obj":"NNS"},{"id":"T4317","span":{"begin":102,"end":111},"obj":"JJ"},{"id":"T4316","span":{"begin":93,"end":101},"obj":"VB"},{"id":"T4315","span":{"begin":90,"end":92},"obj":"TO"},{"id":"T4314","span":{"begin":86,"end":89},"obj":"CC"},{"id":"T4313","span":{"begin":84,"end":86},"obj":","},{"id":"T4312","span":{"begin":66,"end":73},"obj":"JJ"},{"id":"T4311","span":{"begin":60,"end":65},"obj":"JJ"},{"id":"T4310","span":{"begin":74,"end":84},"obj":"NN"},{"id":"T4309","span":{"begin":56,"end":59},"obj":"DT"},{"id":"T4308","span":{"begin":53,"end":55},"obj":"IN"},{"id":"T4307","span":{"begin":41,"end":44},"obj":"CD"},{"id":"T4306","span":{"begin":37,"end":40},"obj":"CC"},{"id":"T4305","span":{"begin":45,"end":52},"obj":"NNS"},{"id":"T4304","span":{"begin":34,"end":36},"obj":"NN"},{"id":"T4303","span":{"begin":31,"end":33},"obj":"IN"},{"id":"T4302","span":{"begin":17,"end":30},"obj":"NNS"},{"id":"T4301","span":{"begin":13,"end":16},"obj":"DT"},{"id":"T4300","span":{"begin":143,"end":151},"obj":"VBN"},{"id":"T4299","span":{"begin":3,"end":12},"obj":"VB"},{"id":"T4298","span":{"begin":0,"end":2},"obj":"TO"},{"id":"T4434","span":{"begin":656,"end":657},"obj":"."},{"id":"T4433","span":{"begin":655,"end":656},"obj":"-RRB-"},{"id":"T4432","span":{"begin":653,"end":655},"obj":"CD"}],"relations":[{"id":"R2539","pred":"aux","subj":"T4298","obj":"T4299"},{"id":"R2540","pred":"advcl","subj":"T4299","obj":"T4300"},{"id":"R2541","pred":"det","subj":"T4301","obj":"T4302"},{"id":"R2542","pred":"dobj","subj":"T4302","obj":"T4299"},{"id":"R2543","pred":"prep","subj":"T4303","obj":"T4302"},{"id":"R2544","pred":"nmod","subj":"T4304","obj":"T4305"},{"id":"R2545","pred":"pobj","subj":"T4305","obj":"T4303"},{"id":"R2546","pred":"cc","subj":"T4306","obj":"T4304"},{"id":"R2547","pred":"conj","subj":"T4307","obj":"T4304"},{"id":"R2548","pred":"prep","subj":"T4308","obj":"T4302"},{"id":"R2549","pred":"det","subj":"T4309","obj":"T4310"},{"id":"R2550","pred":"pobj","subj":"T4310","obj":"T4308"},{"id":"R2551","pred":"amod","subj":"T4311","obj":"T4310"},{"id":"R2552","pred":"amod","subj":"T4312","obj":"T4310"},{"id":"R2553","pred":"punct","subj":"T4313","obj":"T4299"},{"id":"R2554","pred":"cc","subj":"T4314","obj":"T4299"},{"id":"R2555","pred":"aux","subj":"T4315","obj":"T4316"},{"id":"R2556","pred":"conj","subj":"T4316","obj":"T4299"},{"id":"R2557","pred":"amod","subj":"T4317","obj":"T4318"},{"id":"R2558","pred":"dobj","subj":"T4318","obj":"T4316"},{"id":"R2559","pred":"compound","subj":"T4319","obj":"T4318"},{"id":"R2560","pred":"punct","subj":"T4320","obj":"T4300"},{"id":"R2561","pred":"compound","subj":"T4321","obj":"T4322"},{"id":"R2562","pred":"nsubjpass","subj":"T4322","obj":"T4300"},{"id":"R2563","pred":"auxpass","subj":"T4323","obj":"T4300"},{"id":"R2564","pred":"prep","subj":"T4324","obj":"T4300"},{"id":"R2565","pred":"pobj","subj":"T4325","obj":"T4324"},{"id":"R2566","pred":"prep","subj":"T4326","obj":"T4300"},{"id":"R2567","pred":"pobj","subj":"T4327","obj":"T4326"},{"id":"R2568","pred":"prep","subj":"T4328","obj":"T4327"},{"id":"R2569","pred":"pobj","subj":"T4329","obj":"T4328"},{"id":"R2570","pred":"prep","subj":"T4330","obj":"T4329"},{"id":"R2571","pred":"det","subj":"T4331","obj":"T4332"},{"id":"R2572","pred":"pobj","subj":"T4332","obj":"T4330"},{"id":"R2573","pred":"nummod","subj":"T4333","obj":"T4332"},{"id":"R2574","pred":"compound","subj":"T4334","obj":"T4332"},{"id":"R2575","pred":"punct","subj":"T4335","obj":"T4300"},{"id":"R2576","pred":"nsubjpass","subj":"T4337","obj":"T4338"},{"id":"R2577","pred":"amod","subj":"T4339","obj":"T4337"},{"id":"R2578","pred":"prep","subj":"T4340","obj":"T4339"},{"id":"R2579","pred":"det","subj":"T4341","obj":"T4342"},{"id":"R2580","pred":"pobj","subj":"T4342","obj":"T4340"},{"id":"R2581","pred":"compound","subj":"T4343","obj":"T4342"},{"id":"R2582","pred":"punct","subj":"T4344","obj":"T4337"},{"id":"R2583","pred":"dep","subj":"T4345","obj":"T4346"},{"id":"R2584","pred":"relcl","subj":"T4346","obj":"T4337"},{"id":"R2585","pred":"auxpass","subj":"T4347","obj":"T4346"},{"id":"R2586","pred":"prep","subj":"T4348","obj":"T4346"},{"id":"R2587","pred":"pobj","subj":"T4349","obj":"T4348"},{"id":"R2588","pred":"advmod","subj":"T4350","obj":"T4351"},{"id":"R2589","pred":"prep","subj":"T4351","obj":"T4349"},{"id":"R2590","pred":"det","subj":"T4352","obj":"T4353"},{"id":"R2591","pred":"pobj","subj":"T4353","obj":"T4351"},{"id":"R2592","pred":"nmod","subj":"T4354","obj":"T4353"},{"id":"R2593","pred":"punct","subj":"T4355","obj":"T4354"},{"id":"R2594","pred":"nummod","subj":"T4356","obj":"T4354"},{"id":"R2595","pred":"amod","subj":"T4357","obj":"T4353"},{"id":"R2596","pred":"punct","subj":"T4358","obj":"T4338"},{"id":"R2597","pred":"auxpass","subj":"T4359","obj":"T4338"},{"id":"R2598","pred":"advmod","subj":"T4360","obj":"T4338"},{"id":"R2599","pred":"aux","subj":"T4361","obj":"T4362"},{"id":"R2600","pred":"advcl","subj":"T4362","obj":"T4338"},{"id":"R2601","pred":"nsubj","subj":"T4363","obj":"T4364"},{"id":"R2602","pred":"advcl","subj":"T4364","obj":"T4362"},{"id":"R2603","pred":"amod","subj":"T4365","obj":"T4366"},{"id":"R2604","pred":"attr","subj":"T4366","obj":"T4364"},{"id":"R2605","pred":"punct","subj":"T4367","obj":"T4338"},{"id":"R2606","pred":"nummod","subj":"T4369","obj":"T4370"},{"id":"R2607","pred":"nsubj","subj":"T4370","obj":"T4372"},{"id":"R2608","pred":"compound","subj":"T4371","obj":"T4370"},{"id":"R2609","pred":"prep","subj":"T4373","obj":"T4370"},{"id":"R2610","pred":"det","subj":"T4374","obj":"T4375"},{"id":"R2611","pred":"pobj","subj":"T4375","obj":"T4373"},{"id":"R2612","pred":"compound","subj":"T4376","obj":"T4375"},{"id":"R2613","pred":"nummod","subj":"T4377","obj":"T4378"},{"id":"R2614","pred":"compound","subj":"T4378","obj":"T4379"},{"id":"R2615","pred":"dobj","subj":"T4379","obj":"T4372"},{"id":"R2616","pred":"compound","subj":"T4380","obj":"T4379"},{"id":"R2617","pred":"punct","subj":"T4381","obj":"T4372"},{"id":"R2618","pred":"nsubj","subj":"T4383","obj":"T4384"},{"id":"R2619","pred":"prep","subj":"T4385","obj":"T4383"},{"id":"R2620","pred":"det","subj":"T4386","obj":"T4387"},{"id":"R2621","pred":"pobj","subj":"T4387","obj":"T4385"},{"id":"R2622","pred":"nummod","subj":"T4388","obj":"T4387"},{"id":"R2623","pred":"dobj","subj":"T4389","obj":"T4384"},{"id":"R2624","pred":"prep","subj":"T4390","obj":"T4389"},{"id":"R2625","pred":"det","subj":"T4391","obj":"T4392"},{"id":"R2626","pred":"pobj","subj":"T4392","obj":"T4390"},{"id":"R2627","pred":"prep","subj":"T4393","obj":"T4384"},{"id":"R2628","pred":"pobj","subj":"T4394","obj":"T4393"},{"id":"R2629","pred":"punct","subj":"T4395","obj":"T4394"},{"id":"R2630","pred":"nummod","subj":"T4396","obj":"T4397"},{"id":"R2631","pred":"npadvmod","subj":"T4397","obj":"T4394"},{"id":"R2632","pred":"punct","subj":"T4398","obj":"T4384"},{"id":"R2633","pred":"det","subj":"T4400","obj":"T4401"},{"id":"R2634","pred":"nsubj","subj":"T4401","obj":"T4403"},{"id":"R2635","pred":"nummod","subj":"T4402","obj":"T4401"},{"id":"R2636","pred":"preconj","subj":"T4404","obj":"T4405"},{"id":"R2637","pred":"nmod","subj":"T4405","obj":"T4406"},{"id":"R2638","pred":"dobj","subj":"T4406","obj":"T4403"},{"id":"R2639","pred":"cc","subj":"T4407","obj":"T4405"},{"id":"R2640","pred":"conj","subj":"T4408","obj":"T4405"},{"id":"R2641","pred":"prep","subj":"T4409","obj":"T4403"},{"id":"R2642","pred":"pobj","subj":"T4410","obj":"T4409"},{"id":"R2643","pred":"nummod","subj":"T4411","obj":"T4410"},{"id":"R2644","pred":"punct","subj":"T4412","obj":"T4410"},{"id":"R2645","pred":"nummod","subj":"T4413","obj":"T4414"},{"id":"R2646","pred":"npadvmod","subj":"T4414","obj":"T4410"},{"id":"R2647","pred":"dep","subj":"T4415","obj":"T4416"},{"id":"R2648","pred":"advcl","subj":"T4416","obj":"T4403"},{"id":"R2649","pred":"advmod","subj":"T4417","obj":"T4416"},{"id":"R2650","pred":"prep","subj":"T4418","obj":"T4416"},{"id":"R2651","pred":"pcomp","subj":"T4419","obj":"T4418"},{"id":"R2652","pred":"det","subj":"T4420","obj":"T4421"},{"id":"R2653","pred":"pobj","subj":"T4421","obj":"T4418"},{"id":"R2654","pred":"amod","subj":"T4422","obj":"T4421"},{"id":"R2655","pred":"compound","subj":"T4423","obj":"T4421"},{"id":"R2656","pred":"dep","subj":"T4424","obj":"T4425"},{"id":"R2657","pred":"relcl","subj":"T4425","obj":"T4421"},{"id":"R2658","pred":"prep","subj":"T4426","obj":"T4425"},{"id":"R2659","pred":"pobj","subj":"T4427","obj":"T4426"},{"id":"R2660","pred":"punct","subj":"T4428","obj":"T4427"},{"id":"R2661","pred":"nummod","subj":"T4429","obj":"T4430"},{"id":"R2662","pred":"npadvmod","subj":"T4430","obj":"T4427"},{"id":"R2663","pred":"punct","subj":"T4431","obj":"T4432"},{"id":"R2664","pred":"parataxis","subj":"T4432","obj":"T4403"},{"id":"R2665","pred":"punct","subj":"T4433","obj":"T4432"},{"id":"R2666","pred":"punct","subj":"T4434","obj":"T4403"}],"text":"To determine the contributions of B6 and 129 alleles to the mixed genetic background, and to identify potential modifier regions, tail DNA was analyzed by PCR for markers of polymorphisms between these two mouse strains. Mice congenic on the B6 background, which were derived from mice originally on a B6/129 mixed background, were also analyzed to confirm they are congenic B6. Twelve CF mice on the B6 background averaged 99.5% B6 alleles. One of the twelve mice had alleles from both strains at chr.9, 40 cM. All twelve mice had both B6 and 129 markers on chromosome 6, 1 cM which is probably due to the targeted Cftr gene which is at chr.6, 3.1 cM [36]."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T4077","span":{"begin":638,"end":642},"obj":"GO_SO_EXT:chromosome"},{"id":"T4076","span":{"begin":621,"end":625},"obj":"SO_EXT:0000704"},{"id":"T4075","span":{"begin":616,"end":620},"obj":"PR_EXT:000001044"},{"id":"T4074","span":{"begin":559,"end":569},"obj":"GO_SO_EXT:chromosome"},{"id":"T4073","span":{"begin":548,"end":555},"obj":"CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag"},{"id":"T4072","span":{"begin":523,"end":527},"obj":"NCBITaxon:10088"},{"id":"T4071","span":{"begin":498,"end":502},"obj":"GO_SO_EXT:chromosome"},{"id":"T4070","span":{"begin":469,"end":476},"obj":"SO_EXT:0001023"},{"id":"T4069","span":{"begin":460,"end":464},"obj":"NCBITaxon:10088"},{"id":"T4068","span":{"begin":433,"end":440},"obj":"SO_EXT:0001023"},{"id":"T4067","span":{"begin":389,"end":393},"obj":"NCBITaxon:10088"},{"id":"T4066","span":{"begin":281,"end":285},"obj":"NCBITaxon:10088"},{"id":"T4065","span":{"begin":221,"end":225},"obj":"NCBITaxon:10088"},{"id":"T4064","span":{"begin":206,"end":211},"obj":"NCBITaxon:10088"},{"id":"T4063","span":{"begin":174,"end":187},"obj":"SO_EXT:polymorphism"},{"id":"T4062","span":{"begin":163,"end":170},"obj":"CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag"},{"id":"T4061","span":{"begin":135,"end":138},"obj":"CHEBI_SO_EXT:DNA"},{"id":"T4060","span":{"begin":130,"end":134},"obj":"UBERON:0002415"},{"id":"T4059","span":{"begin":66,"end":73},"obj":"SO_EXT:0000704"},{"id":"T4058","span":{"begin":45,"end":52},"obj":"SO_EXT:0001023"}],"text":"To determine the contributions of B6 and 129 alleles to the mixed genetic background, and to identify potential modifier regions, tail DNA was analyzed by PCR for markers of polymorphisms between these two mouse strains. Mice congenic on the B6 background, which were derived from mice originally on a B6/129 mixed background, were also analyzed to confirm they are congenic B6. Twelve CF mice on the B6 background averaged 99.5% B6 alleles. One of the twelve mice had alleles from both strains at chr.9, 40 cM. All twelve mice had both B6 and 129 markers on chromosome 6, 1 cM which is probably due to the targeted Cftr gene which is at chr.6, 3.1 cM [36]."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T3934","span":{"begin":621,"end":625},"obj":"SO:0000704"},{"id":"T3933","span":{"begin":616,"end":620},"obj":"PR:000001044"},{"id":"T3932","span":{"begin":523,"end":527},"obj":"NCBITaxon:10088"},{"id":"T3931","span":{"begin":469,"end":476},"obj":"SO:0001023"},{"id":"T3930","span":{"begin":460,"end":464},"obj":"NCBITaxon:10088"},{"id":"T3929","span":{"begin":433,"end":440},"obj":"SO:0001023"},{"id":"T3928","span":{"begin":389,"end":393},"obj":"NCBITaxon:10088"},{"id":"T3927","span":{"begin":281,"end":285},"obj":"NCBITaxon:10088"},{"id":"T3926","span":{"begin":221,"end":225},"obj":"NCBITaxon:10088"},{"id":"T3925","span":{"begin":206,"end":211},"obj":"NCBITaxon:10088"},{"id":"T3924","span":{"begin":130,"end":134},"obj":"UBERON:0002415"},{"id":"T3923","span":{"begin":66,"end":73},"obj":"SO:0000704"},{"id":"T3922","span":{"begin":45,"end":52},"obj":"SO:0001023"}],"text":"To determine the contributions of B6 and 129 alleles to the mixed genetic background, and to identify potential modifier regions, tail DNA was analyzed by PCR for markers of polymorphisms between these two mouse strains. Mice congenic on the B6 background, which were derived from mice originally on a B6/129 mixed background, were also analyzed to confirm they are congenic B6. Twelve CF mice on the B6 background averaged 99.5% B6 alleles. One of the twelve mice had alleles from both strains at chr.9, 40 cM. All twelve mice had both B6 and 129 markers on chromosome 6, 1 cM which is probably due to the targeted Cftr gene which is at chr.6, 3.1 cM [36]."}