Id |
Subject |
Object |
Predicate |
Lexical cue |
T7419 |
1296-1301 |
JJ |
denotes |
mixed |
T7418 |
1292-1295 |
CC |
denotes |
and |
T7417 |
1289-1291 |
NN |
denotes |
B6 |
T7416 |
1302-1313 |
NNS |
denotes |
backgrounds |
T7415 |
1285-1288 |
DT |
denotes |
the |
T7414 |
1282-1284 |
IN |
denotes |
on |
T7413 |
1268-1281 |
NNS |
denotes |
heterozygotes |
T7412 |
1263-1267 |
NN |
denotes |
Cftr |
T7411 |
1254-1262 |
VBG |
denotes |
breeding |
T7410 |
1249-1253 |
IN |
denotes |
from |
T7409 |
1239-1248 |
NN |
denotes |
offspring |
T7408 |
1234-1238 |
JJ |
denotes |
male |
T7407 |
1231-1233 |
IN |
denotes |
in |
T7406 |
1221-1230 |
NNS |
denotes |
genotypes |
T7405 |
1216-1220 |
NN |
denotes |
Cftr |
T7404 |
1213-1215 |
IN |
denotes |
of |
T7403 |
1200-1212 |
NN |
denotes |
Distribution |
T7364 |
3077-3078 |
. |
denotes |
. |
T7363 |
3076-3077 |
-RRB- |
denotes |
) |
T7362 |
3068-3069 |
SYM |
denotes |
< |
T7361 |
3066-3067 |
NN |
denotes |
P |
T7360 |
3070-3076 |
CD |
denotes |
0.0005 |
T7359 |
3065-3066 |
-LRB- |
denotes |
( |
T7358 |
3060-3064 |
NN |
denotes |
type |
T7357 |
3055-3059 |
JJ |
denotes |
wild |
T7356 |
3050-3054 |
IN |
denotes |
than |
T7355 |
3042-3049 |
JJR |
denotes |
earlier |
T7354 |
3028-3041 |
RB |
denotes |
significantly |
T7353 |
3018-3022 |
RB |
denotes |
also |
T7352 |
3004-3006 |
NN |
denotes |
B6 |
T7351 |
3007-3017 |
NN |
denotes |
background |
T7350 |
3000-3003 |
DT |
denotes |
the |
T7349 |
2997-2999 |
IN |
denotes |
on |
T7348 |
3023-3027 |
VBD |
denotes |
died |
T7347 |
2992-2996 |
NNS |
denotes |
mice |
T7346 |
2989-2991 |
NN |
denotes |
CF |
T7345 |
2988-3078 |
sentence |
denotes |
CF mice on the B6 background also died significantly earlier than wild type (P < 0.0005). |
T7344 |
2987-2988 |
. |
denotes |
. |
T7343 |
2986-2987 |
-RRB- |
denotes |
) |
T7342 |
2979-2980 |
SYM |
denotes |
= |
T7341 |
2977-2978 |
NN |
denotes |
P |
T7340 |
2981-2986 |
CD |
denotes |
0.025 |
T7339 |
2976-2977 |
-LRB- |
denotes |
( |
T7338 |
2962-2964 |
NN |
denotes |
B6 |
T7337 |
2965-2975 |
NN |
denotes |
background |
T7336 |
2958-2961 |
DT |
denotes |
the |
T7335 |
2955-2957 |
IN |
denotes |
on |
T7334 |
2950-2954 |
NNS |
denotes |
mice |
T7333 |
2947-2949 |
NN |
denotes |
CF |
T7332 |
2942-2946 |
IN |
denotes |
than |
T7331 |
2930-2935 |
JJR |
denotes |
later |
T7330 |
2936-2941 |
NN |
denotes |
death |
T7329 |
2916-2929 |
RB |
denotes |
significantly |
T7328 |
2912-2915 |
CC |
denotes |
and |
T7327 |
2910-2912 |
, |
denotes |
, |
T7326 |
2909-2910 |
-RRB- |
denotes |
) |
T7325 |
2902-2903 |
SYM |
denotes |
= |
T7324 |
2900-2901 |
NN |
denotes |
P |
T7323 |
2904-2909 |
CD |
denotes |
0.035 |
T7322 |
2899-2900 |
-LRB- |
denotes |
( |
T7321 |
2894-2898 |
NN |
denotes |
type |
T7320 |
2889-2893 |
JJ |
denotes |
wild |
T7319 |
2886-2888 |
IN |
denotes |
to |
T7318 |
2877-2885 |
VBN |
denotes |
compared |
T7317 |
2871-2876 |
NN |
denotes |
death |
T7316 |
2863-2870 |
JJR |
denotes |
earlier |
T7315 |
2849-2862 |
RB |
denotes |
significantly |
T7314 |
2828-2833 |
JJ |
denotes |
mixed |
T7313 |
2834-2844 |
NN |
denotes |
background |
T7312 |
2824-2827 |
DT |
denotes |
the |
T7311 |
2821-2823 |
IN |
denotes |
on |
T7310 |
2816-2820 |
NNS |
denotes |
mice |
T7309 |
2813-2815 |
NN |
denotes |
CF |
T7308 |
2811-2813 |
, |
denotes |
, |
T7307 |
2807-2811 |
NN |
denotes |
test |
T7306 |
2801-2802 |
HYPH |
denotes |
- |
T7305 |
2802-2806 |
NN |
denotes |
rank |
T7304 |
2798-2801 |
NN |
denotes |
log |
T7303 |
2845-2848 |
VBD |
denotes |
had |
T7302 |
2795-2797 |
IN |
denotes |
By |
T7301 |
2794-2988 |
sentence |
denotes |
By log-rank test, CF mice on the mixed background had significantly earlier death compared to wild type (P = 0.035), and significantly later death than CF mice on the B6 background (P = 0.025). |
T7300 |
2793-2794 |
. |
denotes |
. |
T7299 |
2779-2789 |
JJ |
denotes |
subsequent |
T7298 |
2790-2793 |
NN |
denotes |
day |
T7297 |
2775-2778 |
DT |
denotes |
the |
T7296 |
2772-2774 |
IN |
denotes |
as |
T7295 |
2761-2762 |
'' |
denotes |
' |
T7294 |
2756-2761 |
NN |
denotes |
death |
T7293 |
2763-2771 |
VBN |
denotes |
recorded |
T7292 |
2755-2756 |
`` |
denotes |
' |
T7291 |
2751-2754 |
CC |
denotes |
and |
T7290 |
2735-2739 |
VBD |
denotes |
were |
T7289 |
2726-2734 |
NN |
denotes |
distress |
T7288 |
2718-2725 |
JJ |
denotes |
obvious |
T7287 |
2715-2717 |
IN |
denotes |
in |
T7286 |
2740-2750 |
VBN |
denotes |
sacrificed |
T7285 |
2710-2714 |
NNS |
denotes |
mice |
T7284 |
2706-2709 |
CC |
denotes |
and |
T7283 |
2692-2696 |
PRP |
denotes |
they |
T7282 |
2697-2705 |
VBD |
denotes |
occurred |
T7281 |
2689-2691 |
IN |
denotes |
as |
T7280 |
2675-2679 |
VBD |
denotes |
were |
T7279 |
2680-2688 |
VBN |
denotes |
recorded |
T7278 |
2668-2674 |
NNS |
denotes |
Deaths |
T7277 |
2667-2794 |
sentence |
denotes |
Deaths were recorded as they occurred and mice in obvious distress were sacrificed and 'death' recorded as the subsequent day. |
T7276 |
2666-2667 |
. |
denotes |
. |
T7275 |
2650-2660 |
JJ |
denotes |
additional |
T7274 |
2661-2666 |
NNS |
denotes |
weeks |
T7273 |
2645-2647 |
IN |
denotes |
to |
T7272 |
2648-2649 |
CD |
denotes |
8 |
T7271 |
2642-2644 |
IN |
denotes |
up |
T7270 |
2638-2641 |
IN |
denotes |
for |
T7269 |
2627-2632 |
NN |
denotes |
mouse |
T7268 |
2621-2626 |
JJ |
denotes |
solid |
T7267 |
2633-2637 |
NN |
denotes |
chow |
T7266 |
2612-2620 |
JJ |
denotes |
standard |
T7265 |
2603-2607 |
VBD |
denotes |
were |
T7264 |
2598-2602 |
PRP |
denotes |
they |
T7263 |
2593-2597 |
NN |
denotes |
time |
T7262 |
2587-2592 |
WDT |
denotes |
which |
T7261 |
2608-2611 |
VBN |
denotes |
fed |
T7260 |
2584-2586 |
IN |
denotes |
at |
T7259 |
2582-2584 |
, |
denotes |
, |
T7258 |
2579-2582 |
NN |
denotes |
age |
T7257 |
2576-2578 |
IN |
denotes |
of |
T7256 |
2570-2575 |
NNS |
denotes |
weeks |
T7255 |
2568-2569 |
CD |
denotes |
8 |
T7254 |
2562-2567 |
IN |
denotes |
until |
T7253 |
2560-2561 |
-RRB- |
denotes |
) |
T7252 |
2552-2560 |
NNP |
denotes |
Peptamen |
T7251 |
2551-2552 |
-LRB- |
denotes |
( |
T7250 |
2539-2545 |
NN |
denotes |
liquid |
T7249 |
2546-2550 |
NN |
denotes |
diet |
T7248 |
2535-2538 |
DT |
denotes |
the |
T7247 |
2532-2534 |
IN |
denotes |
on |
T7246 |
2516-2520 |
VBD |
denotes |
were |
T7245 |
2521-2531 |
VBN |
denotes |
maintained |
T7244 |
2511-2515 |
NNS |
denotes |
Mice |
T7243 |
2510-2667 |
sentence |
denotes |
Mice were maintained on the liquid diet (Peptamen) until 8 weeks of age, at which time they were fed standard solid mouse chow for up to 8 additional weeks. |
T7242 |
2509-2510 |
. |
denotes |
. |
T7241 |
2505-2509 |
NN |
denotes |
chow |
T7240 |
2499-2504 |
JJ |
denotes |
solid |
T7239 |
2496-2498 |
IN |
denotes |
on |
T7238 |
2481-2486 |
NN |
denotes |
mouse |
T7237 |
2487-2495 |
NN |
denotes |
survival |
T7236 |
2478-2480 |
NN |
denotes |
CF |
T7235 |
2475-2477 |
IN |
denotes |
on |
T7234 |
2464-2474 |
NN |
denotes |
background |
T7233 |
2456-2463 |
JJ |
denotes |
genetic |
T7232 |
2453-2455 |
IN |
denotes |
of |
T7231 |
2446-2452 |
NN |
denotes |
Effect |
T3733 |
2434-2435 |
. |
denotes |
. |
T3732 |
2433-2434 |
-RRB- |
denotes |
) |
T3731 |
2432-2433 |
CD |
denotes |
4 |
T3730 |
2427-2431 |
NN |
denotes |
Fig. |
T3729 |
2426-2427 |
-LRB- |
denotes |
( |
T3728 |
2404-2409 |
JJ |
denotes |
mixed |
T3727 |
2410-2420 |
NN |
denotes |
background |
T3726 |
2400-2403 |
DT |
denotes |
the |
T3725 |
2397-2399 |
IN |
denotes |
on |
T3724 |
2389-2391 |
NN |
denotes |
CF |
T3723 |
2392-2396 |
NNS |
denotes |
mice |
T3722 |
2385-2388 |
DT |
denotes |
the |
T3721 |
2382-2384 |
IN |
denotes |
of |
T3720 |
2380-2381 |
NN |
denotes |
% |
T3719 |
2378-2380 |
CD |
denotes |
22 |
T3718 |
2373-2377 |
RB |
denotes |
only |
T3717 |
2371-2373 |
, |
denotes |
, |
T3716 |
2363-2371 |
NN |
denotes |
contrast |
T3715 |
2421-2425 |
VBD |
denotes |
died |
T3714 |
2360-2362 |
IN |
denotes |
In |
T3713 |
2359-2435 |
sentence |
denotes |
In contrast, only 22% of the CF mice on the mixed background died (Fig. 4). |
T3712 |
2358-2359 |
. |
denotes |
. |
T3711 |
2347-2351 |
NN |
denotes |
week |
T3710 |
2345-2346 |
CD |
denotes |
8 |
T3709 |
2352-2358 |
NN |
denotes |
period |
T3708 |
2341-2344 |
DT |
denotes |
the |
T3707 |
2336-2340 |
IN |
denotes |
over |
T3706 |
2326-2335 |
NN |
denotes |
mortality |
T3705 |
2324-2325 |
NN |
denotes |
% |
T3704 |
2322-2324 |
CD |
denotes |
60 |
T3703 |
2316-2321 |
RB |
denotes |
about |
T3702 |
2311-2315 |
IN |
denotes |
with |
T3701 |
2309-2311 |
, |
denotes |
, |
T3700 |
2305-2309 |
NN |
denotes |
chow |
T3699 |
2299-2304 |
JJ |
denotes |
solid |
T3698 |
2296-2298 |
IN |
denotes |
on |
T3697 |
2290-2295 |
NNS |
denotes |
weeks |
T3696 |
2287-2288 |
SYM |
denotes |
– |
T3695 |
2288-2289 |
CD |
denotes |
3 |
T3694 |
2286-2287 |
CD |
denotes |
2 |
T3693 |
2279-2285 |
IN |
denotes |
within |
T3692 |
2260-2262 |
NN |
denotes |
B6 |
T3691 |
2263-2273 |
NN |
denotes |
background |
T3690 |
2256-2259 |
DT |
denotes |
the |
T3689 |
2253-2255 |
IN |
denotes |
on |
T3688 |
2248-2252 |
NNS |
denotes |
mice |
T3687 |
2245-2247 |
NN |
denotes |
CF |
T3686 |
2242-2244 |
IN |
denotes |
of |
T3685 |
2274-2278 |
VBD |
denotes |
died |
T3684 |
2233-2241 |
NN |
denotes |
majority |
T3683 |
2229-2232 |
DT |
denotes |
The |
T3682 |
2228-2359 |
sentence |
denotes |
The majority of CF mice on the B6 background died within 2–3 weeks on solid chow, with about 60% mortality over the 8 week period. |
T3681 |
2227-2228 |
. |
denotes |
. |
T3680 |
2219-2227 |
VBN |
denotes |
expected |
T3679 |
2216-2218 |
IN |
denotes |
as |
T3678 |
2214-2216 |
, |
denotes |
, |
T3677 |
2210-2214 |
NN |
denotes |
chow |
T3676 |
2207-2209 |
IN |
denotes |
on |
T3675 |
2198-2206 |
NN |
denotes |
survival |
T3674 |
2196-2197 |
NN |
denotes |
% |
T3673 |
2193-2196 |
CD |
denotes |
100 |
T3672 |
2184-2188 |
NNS |
denotes |
mice |
T3671 |
2179-2183 |
NN |
denotes |
type |
T3670 |
2174-2178 |
JJ |
denotes |
wild |
T3669 |
2172-2174 |
, |
denotes |
, |
T3668 |
2171-2172 |
CD |
denotes |
4 |
T3667 |
2166-2170 |
NN |
denotes |
Fig. |
T3666 |
2163-2165 |
IN |
denotes |
in |
T3665 |
2189-2192 |
VBD |
denotes |
had |
T3664 |
2157-2162 |
VBN |
denotes |
shown |
T3663 |
2154-2156 |
IN |
denotes |
As |
T3662 |
2153-2228 |
sentence |
denotes |
As shown in Fig. 4, wild type mice had 100% survival on chow, as expected. |
T3661 |
2152-2153 |
. |
denotes |
. |
T3660 |
2147-2152 |
NNS |
denotes |
weeks |
T3659 |
2138-2140 |
IN |
denotes |
to |
T3658 |
2141-2146 |
CD |
denotes |
eight |
T3657 |
2135-2137 |
IN |
denotes |
up |
T3656 |
2131-2134 |
IN |
denotes |
for |
T3655 |
2126-2130 |
NN |
denotes |
chow |
T3654 |
2120-2125 |
JJ |
denotes |
solid |
T3653 |
2117-2119 |
IN |
denotes |
to |
T3652 |
2108-2116 |
VBN |
denotes |
switched |
T3651 |
2103-2107 |
RB |
denotes |
then |
T3650 |
2099-2102 |
CC |
denotes |
and |
T3649 |
2097-2099 |
, |
denotes |
, |
T3648 |
2094-2097 |
NN |
denotes |
age |
T3647 |
2091-2093 |
IN |
denotes |
of |
T3646 |
2085-2090 |
NNS |
denotes |
weeks |
T3645 |
2083-2084 |
CD |
denotes |
8 |
T3644 |
2077-2082 |
IN |
denotes |
until |
T3643 |
2065-2071 |
NN |
denotes |
liquid |
T3642 |
2072-2076 |
NN |
denotes |
diet |
T3641 |
2061-2064 |
DT |
denotes |
the |
T3640 |
2058-2060 |
IN |
denotes |
on |
T3639 |
2042-2046 |
VBD |
denotes |
were |
T3638 |
2047-2057 |
VBN |
denotes |
maintained |
T3637 |
2037-2041 |
NNS |
denotes |
Mice |
T3636 |
2036-2153 |
sentence |
denotes |
Mice were maintained on the liquid diet until 8 weeks of age, and then switched to solid chow for up to eight weeks. |
T3635 |
2035-2036 |
. |
denotes |
. |
T3634 |
2025-2028 |
VBD |
denotes |
was |
T3633 |
2020-2024 |
NN |
denotes |
chow |
T3632 |
2014-2019 |
JJ |
denotes |
solid |
T3631 |
2011-2013 |
IN |
denotes |
on |
T3630 |
2003-2010 |
VB |
denotes |
survive |
T3629 |
2000-2002 |
TO |
denotes |
to |
T3628 |
1992-1999 |
NN |
denotes |
ability |
T3627 |
1986-1991 |
PRP$ |
denotes |
their |
T3626 |
1984-1986 |
, |
denotes |
, |
T3625 |
1969-1974 |
JJ |
denotes |
small |
T3624 |
1975-1984 |
NN |
denotes |
intestine |
T3623 |
1965-1968 |
DT |
denotes |
the |
T3622 |
1962-1964 |
IN |
denotes |
in |
T3621 |
1943-1948 |
NN |
denotes |
mucus |
T3620 |
1949-1961 |
NN |
denotes |
accumulation |
T3619 |
1938-1942 |
JJR |
denotes |
less |
T3618 |
1934-1937 |
CC |
denotes |
and |
T3617 |
1920-1922 |
NN |
denotes |
B6 |
T3616 |
1923-1933 |
NN |
denotes |
background |
T3615 |
1916-1919 |
DT |
denotes |
the |
T3614 |
1913-1915 |
IN |
denotes |
on |
T3613 |
1908-1912 |
IN |
denotes |
than |
T3612 |
1896-1902 |
NN |
denotes |
weight |
T3611 |
1903-1907 |
NN |
denotes |
gain |
T3610 |
1889-1895 |
JJR |
denotes |
better |
T3609 |
2029-2035 |
VBN |
denotes |
tested |
T3608 |
1868-1873 |
JJ |
denotes |
mixed |
T3607 |
1874-1884 |
NN |
denotes |
background |
T3606 |
1864-1867 |
DT |
denotes |
the |
T3605 |
1861-1863 |
IN |
denotes |
on |
T3604 |
1853-1855 |
NN |
denotes |
CF |
T3603 |
1856-1860 |
NNS |
denotes |
mice |
T3601 |
1885-1888 |
VBD |
denotes |
had |
T3600 |
1843-1848 |
IN |
denotes |
Since |
T3599 |
1842-2036 |
sentence |
denotes |
Since the CF mice on the mixed background had better weight gain than on the B6 background and less mucus accumulation in the small intestine, their ability to survive on solid chow was tested. |
T3598 |
1841-1842 |
. |
denotes |
. |
T3597 |
1840-1841 |
-RRB- |
denotes |
] |
T3596 |
1838-1840 |
CD |
denotes |
35 |
T3595 |
1837-1838 |
-LRB- |
denotes |
[ |
T3594 |
1826-1831 |
NN |
denotes |
mouse |
T3593 |
1820-1825 |
JJ |
denotes |
solid |
T3592 |
1832-1836 |
NN |
denotes |
chow |
T3591 |
1811-1819 |
JJ |
denotes |
standard |
T3590 |
1803-1806 |
VBP |
denotes |
are |
T3589 |
1798-1802 |
NNS |
denotes |
mice |
T3588 |
1794-1797 |
DT |
denotes |
the |
T3587 |
1807-1810 |
VBN |
denotes |
fed |
T3586 |
1789-1793 |
WRB |
denotes |
when |
T3585 |
1777-1779 |
VBZ |
denotes |
is |
T3584 |
1780-1788 |
VBN |
denotes |
worsened |
T3602 |
1849-1852 |
DT |
denotes |
the |
T3428 |
0-2 |
NN |
denotes |
CF |
T3429 |
3-7 |
NNS |
denotes |
mice |
T3430 |
32-36 |
VBP |
denotes |
have |
T3431 |
8-10 |
IN |
denotes |
on |
T3432 |
11-14 |
DT |
denotes |
the |
T3433 |
21-31 |
NN |
denotes |
background |
T3434 |
15-20 |
JJ |
denotes |
mixed |
T3435 |
37-45 |
VBN |
denotes |
improved |
T3436 |
46-54 |
NN |
denotes |
survival |
T3437 |
54-250 |
sentence |
denotes |
As reported by others [34], the expected number of Cftr null mice on the B6 background that survived to weaning was significantly less than that expected from Mendelian genetics (Tables 1 and 2). |
T3438 |
55-57 |
IN |
denotes |
As |
T3439 |
58-66 |
VBN |
denotes |
reported |
T3440 |
167-170 |
VBD |
denotes |
was |
T3441 |
67-69 |
IN |
denotes |
by |
T3442 |
70-76 |
NNS |
denotes |
others |
T3443 |
77-78 |
-LRB- |
denotes |
[ |
T3444 |
78-80 |
CD |
denotes |
34 |
T3445 |
80-81 |
-RRB- |
denotes |
] |
T3446 |
81-83 |
, |
denotes |
, |
T3447 |
83-86 |
DT |
denotes |
the |
T3448 |
96-102 |
NN |
denotes |
number |
T3449 |
87-95 |
VBN |
denotes |
expected |
T3450 |
103-105 |
IN |
denotes |
of |
T3451 |
106-110 |
NN |
denotes |
Cftr |
T3452 |
116-120 |
NNS |
denotes |
mice |
T3453 |
111-115 |
JJ |
denotes |
null |
T3454 |
121-123 |
IN |
denotes |
on |
T3455 |
124-127 |
DT |
denotes |
the |
T3456 |
131-141 |
NN |
denotes |
background |
T3457 |
128-130 |
NN |
denotes |
B6 |
T3458 |
142-146 |
WDT |
denotes |
that |
T3459 |
147-155 |
VBD |
denotes |
survived |
T3460 |
156-158 |
IN |
denotes |
to |
T3461 |
159-166 |
NN |
denotes |
weaning |
T3462 |
171-184 |
RB |
denotes |
significantly |
T3463 |
185-189 |
JJR |
denotes |
less |
T3464 |
190-194 |
IN |
denotes |
than |
T3465 |
195-199 |
DT |
denotes |
that |
T3466 |
200-208 |
VBN |
denotes |
expected |
T3467 |
209-213 |
IN |
denotes |
from |
T3468 |
214-223 |
JJ |
denotes |
Mendelian |
T3469 |
224-232 |
NN |
denotes |
genetics |
T3470 |
233-234 |
-LRB- |
denotes |
( |
T3471 |
241-242 |
CD |
denotes |
1 |
T3472 |
234-240 |
NNS |
denotes |
Tables |
T3473 |
243-246 |
CC |
denotes |
and |
T3474 |
247-248 |
CD |
denotes |
2 |
T3475 |
248-249 |
-RRB- |
denotes |
) |
T3476 |
249-250 |
. |
denotes |
. |
T3477 |
250-321 |
sentence |
denotes |
The degree of significance was greater for male mice (Tables 1 and 2). |
T3478 |
251-254 |
DT |
denotes |
The |
T3479 |
255-261 |
NN |
denotes |
degree |
T3480 |
278-281 |
VBD |
denotes |
was |
T3481 |
262-264 |
IN |
denotes |
of |
T3482 |
265-277 |
NN |
denotes |
significance |
T3483 |
282-289 |
JJR |
denotes |
greater |
T3484 |
290-293 |
IN |
denotes |
for |
T3485 |
294-298 |
JJ |
denotes |
male |
T3486 |
299-303 |
NNS |
denotes |
mice |
T3487 |
304-305 |
-LRB- |
denotes |
( |
T3488 |
312-313 |
CD |
denotes |
1 |
T3489 |
305-311 |
NNS |
denotes |
Tables |
T3490 |
314-317 |
CC |
denotes |
and |
T3491 |
318-319 |
CD |
denotes |
2 |
T3492 |
319-320 |
-RRB- |
denotes |
) |
T3493 |
320-321 |
. |
denotes |
. |
T3494 |
321-471 |
sentence |
denotes |
In contrast, on the mixed background, the distribution of genotypes of female offspring was not significantly different from the expected (Tables 1). |
T3495 |
322-324 |
IN |
denotes |
In |
T3496 |
410-413 |
VBD |
denotes |
was |
T3497 |
325-333 |
NN |
denotes |
contrast |
T3498 |
333-335 |
, |
denotes |
, |
T3499 |
335-337 |
IN |
denotes |
on |
T3500 |
338-341 |
DT |
denotes |
the |
T3501 |
348-358 |
NN |
denotes |
background |
T3502 |
342-347 |
JJ |
denotes |
mixed |
T3503 |
358-360 |
, |
denotes |
, |
T3504 |
360-363 |
DT |
denotes |
the |
T3546 |
589-590 |
-LRB- |
denotes |
( |
T3547 |
590-595 |
NN |
denotes |
Table |
T3548 |
596-597 |
CD |
denotes |
2 |
T3549 |
597-598 |
-RRB- |
denotes |
) |
T3550 |
598-599 |
. |
denotes |
. |
T3551 |
599-695 |
sentence |
denotes |
These data indicate that the mixed background is associated with increased survival of CF mice. |
T3552 |
600-605 |
DT |
denotes |
These |
T3553 |
606-610 |
NNS |
denotes |
data |
T3554 |
611-619 |
VBP |
denotes |
indicate |
T3555 |
620-624 |
IN |
denotes |
that |
T3556 |
649-659 |
VBN |
denotes |
associated |
T3557 |
625-628 |
DT |
denotes |
the |
T3558 |
635-645 |
NN |
denotes |
background |
T3559 |
629-634 |
JJ |
denotes |
mixed |
T3560 |
646-648 |
VBZ |
denotes |
is |
T3561 |
660-664 |
IN |
denotes |
with |
T3562 |
665-674 |
VBN |
denotes |
increased |
T3563 |
675-683 |
NN |
denotes |
survival |
T3564 |
684-686 |
IN |
denotes |
of |
T3565 |
687-689 |
NN |
denotes |
CF |
T3566 |
690-694 |
NNS |
denotes |
mice |
T3567 |
694-695 |
. |
denotes |
. |
T7375 |
705-717 |
NN |
denotes |
Distribution |
T7376 |
718-720 |
IN |
denotes |
of |
T7377 |
721-725 |
NN |
denotes |
Cftr |
T7378 |
726-735 |
NNS |
denotes |
genotypes |
T7379 |
736-738 |
IN |
denotes |
in |
T7380 |
739-745 |
JJ |
denotes |
female |
T7381 |
746-755 |
NN |
denotes |
offspring |
T7382 |
756-760 |
IN |
denotes |
from |
T7383 |
761-769 |
VBG |
denotes |
breeding |
T7384 |
770-774 |
NN |
denotes |
Cftr |
T7385 |
775-788 |
NNS |
denotes |
heterozygotes |
T7386 |
789-791 |
IN |
denotes |
on |
T7387 |
792-795 |
DT |
denotes |
the |
T7388 |
809-820 |
NNS |
denotes |
backgrounds |
T7389 |
796-798 |
NN |
denotes |
B6 |
T7390 |
799-802 |
CC |
denotes |
and |
T7391 |
803-808 |
JJ |
denotes |
mixed |
T7392 |
820-821 |
. |
denotes |
. |
T7420 |
1313-1314 |
. |
denotes |
. |
T3545 |
580-582 |
NN |
denotes |
B6 |
T3583 |
1765-1776 |
NN |
denotes |
obstruction |
T3582 |
1754-1764 |
JJ |
denotes |
intestinal |
T3581 |
1750-1753 |
CC |
denotes |
and |
T3580 |
1748-1750 |
, |
denotes |
, |
T3579 |
1737-1748 |
NN |
denotes |
obstruction |
T3578 |
1726-1736 |
JJ |
denotes |
intestinal |
T3577 |
1718-1722 |
NNS |
denotes |
mice |
T3576 |
1715-1717 |
NN |
denotes |
CF |
T3575 |
1712-1714 |
IN |
denotes |
in |
T3574 |
1706-1711 |
NN |
denotes |
death |
T3573 |
1703-1705 |
IN |
denotes |
of |
T3572 |
1723-1725 |
VBZ |
denotes |
is |
T3571 |
1691-1696 |
JJ |
denotes |
major |
T3570 |
1697-1702 |
NN |
denotes |
cause |
T3569 |
696-1690 |
DT |
denotes |
Table 1 Distribution of Cftr genotypes in female offspring from breeding Cftr heterozygotes on the B6 and mixed backgrounds.
B6 Background Mixed Background
Cftr Observed Expected Observed Expected
+/+ 207 175 57 47
+/- 371 350 88 94
-/- 122 175 42 47
P 0.00001 (0.04533)* 0.21724
Statistical analysis was by Chi-square. (*) P-value if the sample size for the B6 mice is adjusted to be equal to that of the mixed background mice, assuming the same distribution of genotypes.
Table 2 Distribution of Cftr genotypes in male offspring from breeding Cftr heterozygotes on the B6 and mixed backgrounds.
B6 Background Mixed Background
Cftr Observed Expected Observed Expected
+/+ 240 201 57 52
+/- 431 403 115 104
-/- 134 201 36 52
P <0.00001 (0.01612)* 0.03749
Statistical analysis was by Chi-square. (*) P-value if the sample size for the B6 mice is adjusted to be equal to that of the mixed background mice, assuming the same distribution of genotypes. The |
T3568 |
695-1842 |
sentence |
denotes |
Table 1 Distribution of Cftr genotypes in female offspring from breeding Cftr heterozygotes on the B6 and mixed backgrounds.
B6 Background Mixed Background
Cftr Observed Expected Observed Expected
+/+ 207 175 57 47
+/- 371 350 88 94
-/- 122 175 42 47
P 0.00001 (0.04533)* 0.21724
Statistical analysis was by Chi-square. (*) P-value if the sample size for the B6 mice is adjusted to be equal to that of the mixed background mice, assuming the same distribution of genotypes.
Table 2 Distribution of Cftr genotypes in male offspring from breeding Cftr heterozygotes on the B6 and mixed backgrounds.
B6 Background Mixed Background
Cftr Observed Expected Observed Expected
+/+ 240 201 57 52
+/- 431 403 115 104
-/- 134 201 36 52
P <0.00001 (0.01612)* 0.03749
Statistical analysis was by Chi-square. (*) P-value if the sample size for the B6 mice is adjusted to be equal to that of the mixed background mice, assuming the same distribution of genotypes. The major cause of death in CF mice is intestinal obstruction, and intestinal obstruction is worsened when the mice are fed standard solid mouse chow [35]. |
T3505 |
364-376 |
NN |
denotes |
distribution |
T3506 |
377-379 |
IN |
denotes |
of |
T3507 |
380-389 |
NNS |
denotes |
genotypes |
T3508 |
390-392 |
IN |
denotes |
of |
T3509 |
393-399 |
JJ |
denotes |
female |
T3510 |
400-409 |
NN |
denotes |
offspring |
T3511 |
414-417 |
RB |
denotes |
not |
T3512 |
418-431 |
RB |
denotes |
significantly |
T3513 |
432-441 |
JJ |
denotes |
different |
T3514 |
442-446 |
IN |
denotes |
from |
T3515 |
447-450 |
DT |
denotes |
the |
T3516 |
451-459 |
VBN |
denotes |
expected |
T3517 |
460-461 |
-LRB- |
denotes |
( |
T3518 |
461-467 |
NNS |
denotes |
Tables |
T3519 |
468-469 |
CD |
denotes |
1 |
T3520 |
469-470 |
-RRB- |
denotes |
) |
T3521 |
470-471 |
. |
denotes |
. |
T3522 |
471-599 |
sentence |
denotes |
For male mice on the mixed background, the P-value was less significant but still different compared to the B6 males (Table 2). |
T3523 |
472-475 |
IN |
denotes |
For |
T3524 |
523-526 |
VBD |
denotes |
was |
T3525 |
476-480 |
JJ |
denotes |
male |
T3526 |
481-485 |
NNS |
denotes |
mice |
T3527 |
486-488 |
IN |
denotes |
on |
T3528 |
489-492 |
DT |
denotes |
the |
T3529 |
499-509 |
NN |
denotes |
background |
T3530 |
493-498 |
JJ |
denotes |
mixed |
T3531 |
509-511 |
, |
denotes |
, |
T3532 |
511-514 |
DT |
denotes |
the |
T3533 |
517-522 |
NN |
denotes |
value |
T3534 |
515-516 |
NN |
denotes |
P |
T3535 |
516-517 |
HYPH |
denotes |
- |
T3536 |
527-531 |
RBR |
denotes |
less |
T3537 |
532-543 |
JJ |
denotes |
significant |
T3538 |
544-547 |
CC |
denotes |
but |
T3539 |
548-553 |
RB |
denotes |
still |
T3540 |
554-563 |
JJ |
denotes |
different |
T3541 |
564-572 |
VBN |
denotes |
compared |
T3542 |
573-575 |
IN |
denotes |
to |
T3543 |
576-579 |
DT |
denotes |
the |
T3544 |
583-588 |
NNS |
denotes |
males |
R2247 |
T3428 |
T3429 |
compound |
CF,mice |
R2248 |
T3429 |
T3430 |
nsubj |
mice,have |
R2249 |
T3431 |
T3429 |
prep |
on,mice |
R2250 |
T3432 |
T3433 |
det |
the,background |
R2251 |
T3433 |
T3431 |
pobj |
background,on |
R2252 |
T3434 |
T3433 |
amod |
mixed,background |
R2253 |
T3435 |
T3436 |
amod |
improved,survival |
R2254 |
T3436 |
T3430 |
dobj |
survival,have |
R2255 |
T3438 |
T3439 |
mark |
As,reported |
R2256 |
T3439 |
T3440 |
advcl |
reported,was |
R2257 |
T3441 |
T3439 |
agent |
by,reported |
R2258 |
T3442 |
T3441 |
pobj |
others,by |
R2259 |
T3443 |
T3444 |
punct |
[,34 |
R2260 |
T3444 |
T3439 |
parataxis |
34,reported |
R2261 |
T3445 |
T3444 |
punct |
],34 |
R2262 |
T3446 |
T3440 |
punct |
", ",was |
R2263 |
T3447 |
T3448 |
det |
the,number |
R2264 |
T3448 |
T3440 |
nsubj |
number,was |
R2265 |
T3449 |
T3448 |
amod |
expected,number |
R2266 |
T3450 |
T3448 |
prep |
of,number |
R2267 |
T3451 |
T3452 |
nmod |
Cftr,mice |
R2268 |
T3452 |
T3450 |
pobj |
mice,of |
R2269 |
T3453 |
T3452 |
amod |
null,mice |
R2270 |
T3454 |
T3452 |
prep |
on,mice |
R2271 |
T3455 |
T3456 |
det |
the,background |
R2272 |
T3456 |
T3454 |
pobj |
background,on |
R2273 |
T3457 |
T3456 |
compound |
B6,background |
R2274 |
T3458 |
T3459 |
dep |
that,survived |
R2275 |
T3459 |
T3448 |
relcl |
survived,number |
R2276 |
T3460 |
T3459 |
prep |
to,survived |
R2277 |
T3461 |
T3460 |
pobj |
weaning,to |
R2278 |
T3462 |
T3463 |
advmod |
significantly,less |
R2279 |
T3463 |
T3440 |
acomp |
less,was |
R2280 |
T3464 |
T3463 |
prep |
than,less |
R2281 |
T3465 |
T3464 |
pobj |
that,than |
R2282 |
T3466 |
T3465 |
acl |
expected,that |
R2283 |
T3467 |
T3466 |
prep |
from,expected |
R2284 |
T3468 |
T3469 |
amod |
Mendelian,genetics |
R2285 |
T3469 |
T3467 |
pobj |
genetics,from |
R2286 |
T3470 |
T3471 |
punct |
(,1 |
R2287 |
T3471 |
T3440 |
parataxis |
1,was |
R2288 |
T3472 |
T3471 |
nmod |
Tables,1 |
R2289 |
T3473 |
T3471 |
cc |
and,1 |
R2290 |
T3474 |
T3471 |
conj |
2,1 |
R2291 |
T3475 |
T3471 |
punct |
),1 |
R2292 |
T3476 |
T3440 |
punct |
.,was |
R2293 |
T3478 |
T3479 |
det |
The,degree |
R2294 |
T3479 |
T3480 |
nsubj |
degree,was |
R2295 |
T3481 |
T3479 |
prep |
of,degree |
R2296 |
T3482 |
T3481 |
pobj |
significance,of |
R2297 |
T3483 |
T3480 |
acomp |
greater,was |
R2298 |
T3484 |
T3480 |
prep |
for,was |
R2299 |
T3485 |
T3486 |
amod |
male,mice |
R2300 |
T3486 |
T3484 |
pobj |
mice,for |
R2301 |
T3487 |
T3488 |
punct |
(,1 |
R2302 |
T3488 |
T3480 |
parataxis |
1,was |
R2303 |
T3489 |
T3488 |
nmod |
Tables,1 |
R2304 |
T3490 |
T3488 |
cc |
and,1 |
R2305 |
T3491 |
T3488 |
conj |
2,1 |
R2306 |
T3492 |
T3488 |
punct |
),1 |
R2307 |
T3493 |
T3480 |
punct |
.,was |
R2308 |
T3495 |
T3496 |
prep |
In,was |
R2309 |
T3497 |
T3495 |
pobj |
contrast,In |
R2310 |
T3498 |
T3496 |
punct |
", ",was |
R2311 |
T3499 |
T3496 |
prep |
on,was |
R2312 |
T3500 |
T3501 |
det |
the,background |
R2313 |
T3501 |
T3499 |
pobj |
background,on |
R2314 |
T3502 |
T3501 |
amod |
mixed,background |
R2335 |
T3525 |
T3526 |
amod |
male,mice |
R2336 |
T3526 |
T3523 |
pobj |
mice,For |
R2337 |
T3527 |
T3526 |
prep |
on,mice |
R2338 |
T3528 |
T3529 |
det |
the,background |
R2339 |
T3529 |
T3527 |
pobj |
background,on |
R2340 |
T3530 |
T3529 |
amod |
mixed,background |
R2341 |
T3531 |
T3524 |
punct |
", ",was |
R2342 |
T3532 |
T3533 |
det |
the,value |
R2343 |
T3533 |
T3524 |
nsubj |
value,was |
R2344 |
T3534 |
T3533 |
compound |
P,value |
R2345 |
T3535 |
T3533 |
punct |
-,value |
R2346 |
T3536 |
T3537 |
advmod |
less,significant |
R2347 |
T3537 |
T3524 |
acomp |
significant,was |
R2348 |
T3538 |
T3537 |
cc |
but,significant |
R2349 |
T3539 |
T3540 |
advmod |
still,different |
R2350 |
T3540 |
T3537 |
conj |
different,significant |
R2351 |
T3541 |
T3524 |
prep |
compared,was |
R2352 |
T3542 |
T3541 |
prep |
to,compared |
R2353 |
T3543 |
T3544 |
det |
the,males |
R2354 |
T3544 |
T3542 |
pobj |
males,to |
R2355 |
T3545 |
T3544 |
compound |
B6,males |
R2356 |
T3546 |
T3547 |
punct |
(,Table |
R2357 |
T3547 |
T3524 |
parataxis |
Table,was |
R2358 |
T3548 |
T3547 |
nummod |
2,Table |
R2359 |
T3549 |
T3547 |
punct |
),Table |
R2360 |
T3550 |
T3524 |
punct |
.,was |
R2361 |
T3552 |
T3553 |
det |
These,data |
R2362 |
T3553 |
T3554 |
nsubj |
data,indicate |
R2363 |
T3555 |
T3556 |
mark |
that,associated |
R2364 |
T3556 |
T3554 |
ccomp |
associated,indicate |
R2365 |
T3557 |
T3558 |
det |
the,background |
R2366 |
T3558 |
T3556 |
nsubjpass |
background,associated |
R2367 |
T3559 |
T3558 |
amod |
mixed,background |
R2368 |
T3560 |
T3556 |
auxpass |
is,associated |
R2369 |
T3561 |
T3556 |
prep |
with,associated |
R2370 |
T3562 |
T3563 |
amod |
increased,survival |
R2371 |
T3563 |
T3561 |
pobj |
survival,with |
R2372 |
T3564 |
T3563 |
prep |
of,survival |
R2373 |
T3565 |
T3566 |
compound |
CF,mice |
R2374 |
T3566 |
T3564 |
pobj |
mice,of |
R2375 |
T3567 |
T3554 |
punct |
.,indicate |
R2392 |
T3586 |
T3587 |
advmod |
when,fed |
R2393 |
T3587 |
T3584 |
advcl |
fed,worsened |
R2394 |
T3588 |
T3589 |
det |
the,mice |
R2395 |
T3589 |
T3587 |
nsubjpass |
mice,fed |
R2396 |
T3590 |
T3587 |
auxpass |
are,fed |
R2397 |
T3591 |
T3592 |
amod |
standard,chow |
R2398 |
T3592 |
T3587 |
dobj |
chow,fed |
R2399 |
T3593 |
T3592 |
amod |
solid,chow |
R2400 |
T3594 |
T3592 |
compound |
mouse,chow |
R2401 |
T3595 |
T3596 |
punct |
[,35 |
R2402 |
T3596 |
T3584 |
parataxis |
35,worsened |
R2403 |
T3597 |
T3596 |
punct |
],35 |
R2404 |
T3598 |
T3584 |
punct |
.,worsened |
R2405 |
T3600 |
T3601 |
mark |
Since,had |
R2406 |
T3601 |
T3609 |
advcl |
had,tested |
R2407 |
T3602 |
T3603 |
det |
the,mice |
R2408 |
T3603 |
T3601 |
nsubj |
mice,had |
R2409 |
T3604 |
T3603 |
compound |
CF,mice |
R2410 |
T3605 |
T3603 |
prep |
on,mice |
R2411 |
T3606 |
T3607 |
det |
the,background |
R2412 |
T3607 |
T3605 |
pobj |
background,on |
R2413 |
T3608 |
T3607 |
amod |
mixed,background |
R2414 |
T3610 |
T3611 |
amod |
better,gain |
R2415 |
T3611 |
T3601 |
dobj |
gain,had |
R2416 |
T3612 |
T3611 |
compound |
weight,gain |
R2417 |
T3613 |
T3611 |
prep |
than,gain |
R2418 |
T3614 |
T3613 |
prep |
on,than |
R2419 |
T3615 |
T3616 |
det |
the,background |
R2420 |
T3616 |
T3614 |
pobj |
background,on |
R2421 |
T3617 |
T3616 |
compound |
B6,background |
R2422 |
T3618 |
T3611 |
cc |
and,gain |
R2423 |
T3619 |
T3620 |
amod |
less,accumulation |
R2424 |
T3620 |
T3611 |
conj |
accumulation,gain |
R2425 |
T3621 |
T3620 |
compound |
mucus,accumulation |
R2426 |
T3622 |
T3620 |
prep |
in,accumulation |
R2427 |
T3623 |
T3624 |
det |
the,intestine |
R2428 |
T3624 |
T3622 |
pobj |
intestine,in |
R2429 |
T3625 |
T3624 |
amod |
small,intestine |
R2430 |
T3626 |
T3609 |
punct |
", ",tested |
R2431 |
T3627 |
T3628 |
poss |
their,ability |
R2432 |
T3628 |
T3609 |
nsubjpass |
ability,tested |
R2433 |
T3629 |
T3630 |
aux |
to,survive |
R2434 |
T3630 |
T3628 |
acl |
survive,ability |
R2435 |
T3631 |
T3630 |
prep |
on,survive |
R2436 |
T3632 |
T3633 |
amod |
solid,chow |
R2437 |
T3633 |
T3631 |
pobj |
chow,on |
R2438 |
T3634 |
T3609 |
auxpass |
was,tested |
R2439 |
T3635 |
T3609 |
punct |
.,tested |
R2440 |
T3637 |
T3638 |
nsubjpass |
Mice,maintained |
R2441 |
T3639 |
T3638 |
auxpass |
were,maintained |
R2442 |
T3640 |
T3638 |
prep |
on,maintained |
R2443 |
T3641 |
T3642 |
det |
the,diet |
R2444 |
T3642 |
T3640 |
pobj |
diet,on |
R2445 |
T3643 |
T3642 |
compound |
liquid,diet |
R2446 |
T3644 |
T3638 |
prep |
until,maintained |
R2447 |
T3645 |
T3646 |
nummod |
8,weeks |
R2448 |
T3646 |
T3644 |
pobj |
weeks,until |
R2449 |
T3647 |
T3646 |
prep |
of,weeks |
R2450 |
T3648 |
T3647 |
pobj |
age,of |
R2451 |
T3649 |
T3638 |
punct |
", ",maintained |
R2452 |
T3650 |
T3638 |
cc |
and,maintained |
R2453 |
T3651 |
T3650 |
advmod |
then,and |
R2454 |
T3652 |
T3638 |
conj |
switched,maintained |
R2455 |
T3653 |
T3652 |
prep |
to,switched |
R2456 |
T3654 |
T3655 |
amod |
solid,chow |
R2457 |
T3655 |
T3653 |
pobj |
chow,to |
R2458 |
T3656 |
T3652 |
prep |
for,switched |
R2459 |
T3657 |
T3658 |
quantmod |
up,eight |
R2460 |
T3658 |
T3660 |
nummod |
eight,weeks |
R2461 |
T3659 |
T3658 |
quantmod |
to,eight |
R2462 |
T3660 |
T3656 |
pobj |
weeks,for |
R2463 |
T3661 |
T3638 |
punct |
.,maintained |
R2464 |
T3663 |
T3664 |
mark |
As,shown |
R2465 |
T3664 |
T3665 |
advcl |
shown,had |
R2466 |
T3666 |
T3664 |
prep |
in,shown |
R2467 |
T3667 |
T3666 |
pobj |
Fig.,in |
R2468 |
T3668 |
T3667 |
nummod |
4,Fig. |
R2469 |
T3669 |
T3665 |
punct |
", ",had |
R2470 |
T3670 |
T3671 |
amod |
wild,type |
R2471 |
T3671 |
T3672 |
compound |
type,mice |
R2472 |
T3672 |
T3665 |
nsubj |
mice,had |
R2473 |
T3673 |
T3674 |
nummod |
100,% |
R2474 |
T3674 |
T3675 |
compound |
%,survival |
R2475 |
T3675 |
T3665 |
dobj |
survival,had |
R2476 |
T3676 |
T3665 |
prep |
on,had |
R2477 |
T3677 |
T3676 |
pobj |
chow,on |
R2478 |
T3678 |
T3665 |
punct |
", ",had |
R2479 |
T3679 |
T3680 |
mark |
as,expected |
R2480 |
T3680 |
T3665 |
advcl |
expected,had |
R2481 |
T3681 |
T3665 |
punct |
.,had |
R2482 |
T3683 |
T3684 |
det |
The,majority |
R2483 |
T3684 |
T3685 |
nsubj |
majority,died |
R2484 |
T3686 |
T3684 |
prep |
of,majority |
R2485 |
T3687 |
T3688 |
compound |
CF,mice |
R2486 |
T3688 |
T3686 |
pobj |
mice,of |
R2487 |
T3689 |
T3688 |
prep |
on,mice |
R2488 |
T3690 |
T3691 |
det |
the,background |
R2489 |
T3691 |
T3689 |
pobj |
background,on |
R2490 |
T3692 |
T3691 |
compound |
B6,background |
R2491 |
T3693 |
T3685 |
prep |
within,died |
R2492 |
T3694 |
T3695 |
quantmod |
2,3 |
R2493 |
T3695 |
T3697 |
nummod |
3,weeks |
R2494 |
T3696 |
T3695 |
punct |
–,3 |
R2495 |
T3697 |
T3693 |
pobj |
weeks,within |
R2496 |
T3698 |
T3685 |
prep |
on,died |
R2497 |
T3699 |
T3700 |
amod |
solid,chow |
R2498 |
T3700 |
T3698 |
pobj |
chow,on |
R2499 |
T3701 |
T3685 |
punct |
", ",died |
R2500 |
T3702 |
T3685 |
prep |
with,died |
R2501 |
T3703 |
T3704 |
advmod |
about,60 |
R2502 |
T3704 |
T3705 |
nummod |
60,% |
R2503 |
T3705 |
T3706 |
compound |
%,mortality |
R2504 |
T3706 |
T3702 |
pobj |
mortality,with |
R2505 |
T3707 |
T3706 |
prep |
over,mortality |
R2506 |
T3708 |
T3709 |
det |
the,period |
R2507 |
T3709 |
T3707 |
pobj |
period,over |
R2508 |
T3710 |
T3711 |
nummod |
8,week |
R2509 |
T3711 |
T3709 |
compound |
week,period |
R2510 |
T3712 |
T3685 |
punct |
.,died |
R2511 |
T3714 |
T3715 |
prep |
In,died |
R2512 |
T3716 |
T3714 |
pobj |
contrast,In |
R2513 |
T3717 |
T3715 |
punct |
", ",died |
R2514 |
T3718 |
T3719 |
advmod |
only,22 |
R2515 |
T3719 |
T3720 |
nummod |
22,% |
R2516 |
T3720 |
T3715 |
nsubj |
%,died |
R2517 |
T3721 |
T3720 |
prep |
of,% |
R2518 |
T3722 |
T3723 |
det |
the,mice |
R2519 |
T3723 |
T3721 |
pobj |
mice,of |
R2520 |
T3724 |
T3723 |
compound |
CF,mice |
R2521 |
T3725 |
T3723 |
prep |
on,mice |
R2522 |
T3726 |
T3727 |
det |
the,background |
R2523 |
T3727 |
T3725 |
pobj |
background,on |
R2524 |
T3728 |
T3727 |
amod |
mixed,background |
R2525 |
T3729 |
T3730 |
punct |
(,Fig. |
R2526 |
T3730 |
T3715 |
parataxis |
Fig.,died |
R2527 |
T3731 |
T3730 |
nummod |
4,Fig. |
R2528 |
T3732 |
T3730 |
punct |
),Fig. |
R2529 |
T3733 |
T3715 |
punct |
.,died |
R4865 |
T7232 |
T7231 |
prep |
of,Effect |
R4866 |
T7233 |
T7234 |
amod |
genetic,background |
R4867 |
T7234 |
T7232 |
pobj |
background,of |
R4868 |
T7235 |
T7231 |
prep |
on,Effect |
R4869 |
T7236 |
T7237 |
compound |
CF,survival |
R4870 |
T7237 |
T7235 |
pobj |
survival,on |
R4871 |
T7238 |
T7237 |
compound |
mouse,survival |
R4872 |
T7239 |
T7237 |
prep |
on,survival |
R4873 |
T7240 |
T7241 |
amod |
solid,chow |
R4874 |
T7241 |
T7239 |
pobj |
chow,on |
R4875 |
T7242 |
T7231 |
punct |
.,Effect |
R4876 |
T7244 |
T7245 |
nsubjpass |
Mice,maintained |
R4877 |
T7246 |
T7245 |
auxpass |
were,maintained |
R4878 |
T7247 |
T7245 |
prep |
on,maintained |
R4879 |
T7248 |
T7249 |
det |
the,diet |
R4880 |
T7249 |
T7247 |
pobj |
diet,on |
R4881 |
T7250 |
T7249 |
compound |
liquid,diet |
R4882 |
T7251 |
T7252 |
punct |
(,Peptamen |
R4883 |
T7252 |
T7249 |
parataxis |
Peptamen,diet |
R4884 |
T7253 |
T7252 |
punct |
),Peptamen |
R4885 |
T7254 |
T7245 |
prep |
until,maintained |
R4886 |
T7255 |
T7256 |
nummod |
8,weeks |
R4887 |
T7256 |
T7254 |
pobj |
weeks,until |
R4888 |
T7257 |
T7256 |
prep |
of,weeks |
R4889 |
T7258 |
T7257 |
pobj |
age,of |
R4890 |
T7259 |
T7256 |
punct |
", ",weeks |
R4891 |
T7260 |
T7261 |
prep |
at,fed |
R4892 |
T7261 |
T7256 |
advcl |
fed,weeks |
R4893 |
T7262 |
T7263 |
det |
which,time |
R4894 |
T7263 |
T7260 |
pcomp |
time,at |
R4895 |
T7264 |
T7261 |
nsubjpass |
they,fed |
R4896 |
T7265 |
T7261 |
auxpass |
were,fed |
R4897 |
T7266 |
T7267 |
amod |
standard,chow |
R4898 |
T7267 |
T7261 |
dobj |
chow,fed |
R4899 |
T7268 |
T7267 |
amod |
solid,chow |
R4900 |
T7269 |
T7267 |
compound |
mouse,chow |
R4901 |
T7270 |
T7261 |
prep |
for,fed |
R4902 |
T7271 |
T7272 |
quantmod |
up,8 |
R4903 |
T7272 |
T7274 |
nummod |
8,weeks |
R4904 |
T7273 |
T7272 |
quantmod |
to,8 |
R4905 |
T7274 |
T7270 |
pobj |
weeks,for |
R4906 |
T7275 |
T7274 |
amod |
additional,weeks |
R4907 |
T7276 |
T7245 |
punct |
.,maintained |
R4908 |
T7278 |
T7279 |
nsubjpass |
Deaths,recorded |
R4909 |
T7280 |
T7279 |
auxpass |
were,recorded |
R4910 |
T7281 |
T7282 |
mark |
as,occurred |
R4911 |
T7282 |
T7279 |
advcl |
occurred,recorded |
R4912 |
T7283 |
T7282 |
nsubj |
they,occurred |
R4913 |
T7284 |
T7279 |
cc |
and,recorded |
R4914 |
T7285 |
T7286 |
nsubjpass |
mice,sacrificed |
R4915 |
T7286 |
T7279 |
conj |
sacrificed,recorded |
R4916 |
T7287 |
T7285 |
prep |
in,mice |
R4917 |
T7288 |
T7289 |
amod |
obvious,distress |
R4918 |
T7289 |
T7287 |
pobj |
distress,in |
R4919 |
T7290 |
T7286 |
auxpass |
were,sacrificed |
R4920 |
T7291 |
T7286 |
cc |
and,sacrificed |
R4921 |
T7292 |
T7293 |
punct |
',recorded |
R4922 |
T7293 |
T7286 |
conj |
recorded,sacrificed |
R4923 |
T7294 |
T7293 |
nsubj |
death,recorded |
R4924 |
T7295 |
T7293 |
punct |
',recorded |
R4925 |
T7296 |
T7293 |
prep |
as,recorded |
R4926 |
T7297 |
T7298 |
det |
the,day |
R4927 |
T7298 |
T7296 |
pobj |
day,as |
R4928 |
T7299 |
T7298 |
amod |
subsequent,day |
R4929 |
T7300 |
T7286 |
punct |
.,sacrificed |
R4930 |
T7302 |
T7303 |
prep |
By,had |
R4931 |
T7304 |
T7305 |
compound |
log,rank |
R4932 |
T7305 |
T7307 |
compound |
rank,test |
R4933 |
T7306 |
T7305 |
punct |
-,rank |
R4934 |
T7307 |
T7302 |
pobj |
test,By |
R4935 |
T7308 |
T7303 |
punct |
", ",had |
R4936 |
T7309 |
T7310 |
compound |
CF,mice |
R4937 |
T7310 |
T7303 |
nsubj |
mice,had |
R4938 |
T7311 |
T7310 |
prep |
on,mice |
R4939 |
T7312 |
T7313 |
det |
the,background |
R4940 |
T7313 |
T7311 |
pobj |
background,on |
R4941 |
T7314 |
T7313 |
amod |
mixed,background |
R4942 |
T7315 |
T7316 |
advmod |
significantly,earlier |
R4943 |
T7316 |
T7317 |
amod |
earlier,death |
R4944 |
T7317 |
T7303 |
dobj |
death,had |
R4945 |
T7318 |
T7317 |
prep |
compared,death |
R4946 |
T7319 |
T7318 |
prep |
to,compared |
R4947 |
T7320 |
T7321 |
amod |
wild,type |
R4948 |
T7321 |
T7319 |
pobj |
type,to |
R4949 |
T7322 |
T7323 |
punct |
(,0.035 |
R4950 |
T7323 |
T7317 |
parataxis |
0.035,death |
R4951 |
T7324 |
T7323 |
nsubj |
P,0.035 |
R4952 |
T7325 |
T7323 |
punct |
=,0.035 |
R4953 |
T7326 |
T7323 |
punct |
),0.035 |
R4954 |
T7327 |
T7317 |
punct |
", ",death |
R4955 |
T7328 |
T7317 |
cc |
and,death |
R4956 |
T7329 |
T7330 |
advmod |
significantly,death |
R4957 |
T7330 |
T7317 |
conj |
death,death |
R4958 |
T7331 |
T7330 |
amod |
later,death |
R4959 |
T7332 |
T7330 |
prep |
than,death |
R4960 |
T7333 |
T7334 |
compound |
CF,mice |
R4961 |
T7334 |
T7332 |
pobj |
mice,than |
R4962 |
T7335 |
T7334 |
prep |
on,mice |
R4963 |
T7336 |
T7337 |
det |
the,background |
R4964 |
T7337 |
T7335 |
pobj |
background,on |
R4965 |
T7338 |
T7337 |
compound |
B6,background |
R4966 |
T7339 |
T7340 |
punct |
(,0.025 |
R4967 |
T7340 |
T7330 |
parataxis |
0.025,death |
R4968 |
T7341 |
T7340 |
nsubj |
P,0.025 |
R4969 |
T7342 |
T7340 |
punct |
=,0.025 |
R4970 |
T7343 |
T7340 |
punct |
),0.025 |
R4971 |
T7344 |
T7303 |
punct |
.,had |
R4972 |
T7346 |
T7347 |
compound |
CF,mice |
R4973 |
T7347 |
T7348 |
nsubj |
mice,died |
R4974 |
T7349 |
T7347 |
prep |
on,mice |
R4975 |
T7350 |
T7351 |
det |
the,background |
R4976 |
T7351 |
T7349 |
pobj |
background,on |
R4977 |
T7352 |
T7351 |
compound |
B6,background |
R4978 |
T7353 |
T7348 |
advmod |
also,died |
R4979 |
T7354 |
T7355 |
advmod |
significantly,earlier |
R4980 |
T7355 |
T7348 |
advcl |
earlier,died |
R4981 |
T7356 |
T7355 |
prep |
than,earlier |
R4982 |
T7357 |
T7358 |
amod |
wild,type |
R4983 |
T7358 |
T7356 |
pobj |
type,than |
R4984 |
T7359 |
T7360 |
punct |
(,0.0005 |
R4985 |
T7360 |
T7348 |
parataxis |
0.0005,died |
R4986 |
T7361 |
T7360 |
nsubj |
P,0.0005 |
R4987 |
T7362 |
T7360 |
punct |
<,0.0005 |
R4988 |
T7363 |
T7360 |
punct |
),0.0005 |
R4989 |
T7364 |
T7348 |
punct |
.,died |
R4990 |
T7376 |
T7375 |
prep |
of,Distribution |
R4991 |
T7377 |
T7378 |
compound |
Cftr,genotypes |
R4992 |
T7378 |
T7376 |
pobj |
genotypes,of |
R4993 |
T7379 |
T7375 |
prep |
in,Distribution |
R4994 |
T7380 |
T7381 |
amod |
female,offspring |
R4995 |
T7381 |
T7379 |
pobj |
offspring,in |
R4996 |
T7382 |
T7381 |
prep |
from,offspring |
R4997 |
T7383 |
T7382 |
pcomp |
breeding,from |
R4998 |
T7384 |
T7385 |
compound |
Cftr,heterozygotes |
R4999 |
T7385 |
T7383 |
dobj |
heterozygotes,breeding |
R5000 |
T7386 |
T7383 |
prep |
on,breeding |
R5001 |
T7387 |
T7388 |
det |
the,backgrounds |
R5002 |
T7388 |
T7386 |
pobj |
backgrounds,on |
R5003 |
T7389 |
T7388 |
nmod |
B6,backgrounds |
R5004 |
T7390 |
T7389 |
cc |
and,B6 |
R5005 |
T7391 |
T7389 |
conj |
mixed,B6 |
R5006 |
T7392 |
T7375 |
punct |
.,Distribution |
R5007 |
T7404 |
T7403 |
prep |
of,Distribution |
R5008 |
T7405 |
T7406 |
compound |
Cftr,genotypes |
R5009 |
T7406 |
T7404 |
pobj |
genotypes,of |
R5010 |
T7407 |
T7403 |
prep |
in,Distribution |
R5011 |
T7408 |
T7409 |
amod |
male,offspring |
R5012 |
T7409 |
T7407 |
pobj |
offspring,in |
R5013 |
T7410 |
T7409 |
prep |
from,offspring |
R5014 |
T7411 |
T7410 |
pcomp |
breeding,from |
R5015 |
T7412 |
T7413 |
compound |
Cftr,heterozygotes |
R5016 |
T7413 |
T7411 |
dobj |
heterozygotes,breeding |
R5017 |
T7414 |
T7411 |
prep |
on,breeding |
R5018 |
T7415 |
T7416 |
det |
the,backgrounds |
R5019 |
T7416 |
T7414 |
pobj |
backgrounds,on |
R5020 |
T7417 |
T7416 |
nmod |
B6,backgrounds |
R5021 |
T7418 |
T7417 |
cc |
and,B6 |
R5022 |
T7419 |
T7417 |
conj |
mixed,B6 |
R5023 |
T7420 |
T7403 |
punct |
.,Distribution |
R2315 |
T3503 |
T3496 |
punct |
", ",was |
R2316 |
T3504 |
T3505 |
det |
the,distribution |
R2317 |
T3505 |
T3496 |
nsubj |
distribution,was |
R2318 |
T3506 |
T3505 |
prep |
of,distribution |
R2319 |
T3507 |
T3506 |
pobj |
genotypes,of |
R2320 |
T3508 |
T3507 |
prep |
of,genotypes |
R2321 |
T3509 |
T3510 |
amod |
female,offspring |
R2322 |
T3510 |
T3508 |
pobj |
offspring,of |
R2323 |
T3511 |
T3496 |
neg |
not,was |
R2324 |
T3512 |
T3513 |
advmod |
significantly,different |
R2325 |
T3513 |
T3496 |
acomp |
different,was |
R2326 |
T3514 |
T3513 |
prep |
from,different |
R2327 |
T3515 |
T3516 |
det |
the,expected |
R2328 |
T3516 |
T3514 |
pobj |
expected,from |
R2329 |
T3517 |
T3518 |
punct |
(,Tables |
R2330 |
T3518 |
T3513 |
parataxis |
Tables,different |
R2331 |
T3519 |
T3518 |
nummod |
1,Tables |
R2332 |
T3520 |
T3518 |
punct |
),Tables |
R2333 |
T3521 |
T3496 |
punct |
.,was |
R2334 |
T3523 |
T3524 |
prep |
For,was |
R2376 |
T3569 |
T3570 |
det |
"Table 1 Distribution of Cftr genotypes in female offspring from breeding Cftr heterozygotes on the B6 and mixed backgrounds.
B6 Background Mixed Background
Cftr Observed Expected Observed Expected
+/+ 207 175 57 47
+/- 371 350 88 94
-/- 122 175 42 47
P 0.00001 (0.04533)* 0.21724
Statistical analysis was by Chi-square. (*) P-value if the sample size for the B6 mice is adjusted to be equal to that of the mixed background mice, assuming the same distribution of genotypes.
Table 2 Distribution of Cftr genotypes in male offspring from breeding Cftr heterozygotes on the B6 and mixed backgrounds.
B6 Background Mixed Background
Cftr Observed Expected Observed Expected
+/+ 240 201 57 52
+/- 431 403 115 104
-/- 134 201 36 52
P <0.00001 (0.01612)* 0.03749
Statistical analysis was by Chi-square. (*) P-value if the sample size for the B6 mice is adjusted to be equal to that of the mixed background mice, assuming the same distribution of genotypes. The",cause |
R2377 |
T3570 |
T3572 |
nsubj |
cause,is |
R2378 |
T3571 |
T3570 |
amod |
major,cause |
R2379 |
T3573 |
T3570 |
prep |
of,cause |
R2380 |
T3574 |
T3573 |
pobj |
death,of |
R2381 |
T3575 |
T3570 |
prep |
in,cause |
R2382 |
T3576 |
T3577 |
compound |
CF,mice |
R2383 |
T3577 |
T3575 |
pobj |
mice,in |
R2384 |
T3578 |
T3579 |
amod |
intestinal,obstruction |
R2385 |
T3579 |
T3572 |
attr |
obstruction,is |
R2386 |
T3580 |
T3572 |
punct |
", ",is |
R2387 |
T3581 |
T3572 |
cc |
and,is |
R2388 |
T3582 |
T3583 |
amod |
intestinal,obstruction |
R2389 |
T3583 |
T3584 |
nsubjpass |
obstruction,worsened |
R2390 |
T3584 |
T3572 |
conj |
worsened,is |
R2391 |
T3585 |
T3584 |
auxpass |
is,worsened |