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PMC:1166548 / 129-2174 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T37 125-129 SO:0000704 denotes gene
T38 211-216 SO:0000704 denotes genes
T39 222-232 UBERON:0000160 denotes intestines
T40 236-240 PR:000001044 denotes Cftr
T41 251-255 NCBITaxon:10088 denotes mice
T42 260-264 NCBITaxon:10088 denotes mice
T43 266-270 PR:000001044 denotes Cftr
T44 316-321 UBERON:0000912 denotes mucus
T45 362-370 UBERON:0007109 denotes meconium
T46 388-398 UBERON:0000160 denotes intestinal
T47 465-472 SO:0000704 denotes genetic
T48 491-495 NCBITaxon:10088 denotes mice
T49 543-547 NCBITaxon:10088 denotes mice
T50 572-577 NCBITaxon:10088 denotes mouse
T51 578-582 CHEBI:33290 denotes chow
T52 609-624 UBERON:0002108 denotes small intestine
T53 727-737 UBERON:0000160 denotes intestinal
T54 777-781 NCBITaxon:10088 denotes mice
T55 793-800 SO:0000704 denotes genetic
T56 859-863 NCBITaxon:10088 denotes mice
T57 929-939 UBERON:0000160 denotes intestinal
T58 957-961 NCBITaxon:10088 denotes mice
T59 1030-1033 GO:0007631 denotes fed
T60 1038-1043 NCBITaxon:10088 denotes mouse
T61 1044-1048 CHEBI:33290 denotes chow
T62 1063-1073 UBERON:0000160 denotes intestinal
T63 1133-1138 SO:0000704 denotes genes
T64 1192-1197 UBERON:0000912 denotes mucus
T33 66-117 PR:000001044 denotes cystic fibrosis transmembrane conductance regulator
T34 82-107 GO:0055085 denotes transmembrane conductance
T35 87-95 GO:0016020 denotes membrane
T36 119-123 PR:000001044 denotes CFTR
T65 1218-1235 UBERON:0001983 denotes intestinal crypts
T66 1477-1483 SO:0001026 denotes genome
T67 1493-1499 SO:0001023 denotes allele
T68 1839-1844 NCBITaxon:10088 denotes mouse
T69 1845-1860 UBERON:0002108 denotes small intestine
T70 1865-1871 NCBITaxon:33208 denotes animal
T71 1926-1931 SO:0000704 denotes genes
T72 1996-2003 SO:0000704 denotes genetic
T73 2024-2034 UBERON:0000160 denotes intestinal

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T79 49-58 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T80 66-117 PR_EXT:000001044 denotes cystic fibrosis transmembrane conductance regulator
T81 82-107 GO:0055085 denotes transmembrane conductance
T82 87-95 GO:0016020 denotes membrane
T83 108-117 GO_EXT:regulator denotes regulator
T84 119-123 PR_EXT:000001044 denotes CFTR
T85 125-129 SO_EXT:0000704 denotes gene
T86 211-216 SO_EXT:0000704 denotes genes
T87 222-232 UBERON:0000160 denotes intestines
T88 236-240 PR_EXT:000001044 denotes Cftr
T89 251-255 NCBITaxon:10088 denotes mice
T90 260-264 NCBITaxon:10088 denotes mice
T91 266-270 PR_EXT:000001044 denotes Cftr
T92 316-321 UBERON:0000912 denotes mucus
T93 362-370 UBERON:0007109 denotes meconium
T94 388-398 UBERON:0000160 denotes intestinal
T95 465-472 SO_EXT:0000704 denotes genetic
T96 491-495 NCBITaxon:10088 denotes mice
T97 543-547 NCBITaxon:10088 denotes mice
T98 572-577 NCBITaxon:10088 denotes mouse
T99 578-582 CHEBI_EXT:33290 denotes chow
T100 589-601 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammation
T101 609-624 UBERON:0002108 denotes small intestine
T102 657-666 SO_EXT:wild_type_entity_or_quality denotes wild type
T103 727-737 UBERON:0000160 denotes intestinal
T104 777-781 NCBITaxon:10088 denotes mice
T105 793-800 SO_EXT:0000704 denotes genetic
T106 859-863 NCBITaxon:10088 denotes mice
T107 929-939 UBERON:0000160 denotes intestinal
T108 957-961 NCBITaxon:10088 denotes mice
T109 1030-1033 GO:0007631 denotes fed
T110 1038-1043 NCBITaxon:10088 denotes mouse
T111 1044-1048 CHEBI_EXT:33290 denotes chow
T112 1063-1073 UBERON:0000160 denotes intestinal
T113 1074-1086 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammation
T114 1115-1117 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T115 1126-1132 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T116 1133-1138 SO_EXT:0000704 denotes genes
T117 1157-1161 UBERON_EXT:body denotes body
T118 1192-1197 UBERON:0000912 denotes mucus
T119 1218-1235 UBERON:0001983 denotes intestinal crypts
T120 1284-1288 UBERON_EXT:body denotes body
T121 1302-1307 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T122 1410-1417 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T123 1477-1483 SO_EXT:0001026 denotes genome
T124 1493-1499 SO_EXT:0001023 denotes allele
T125 1598-1602 GO_SO_EXT:chromosome denotes chr.
T126 1616-1622 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T127 1639-1643 GO_SO_EXT:chromosome denotes chr.
T128 1657-1663 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T129 1684-1688 GO_SO_EXT:chromosome denotes chr.
T130 1704-1710 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T131 1806-1818 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T132 1839-1844 NCBITaxon:10088 denotes mouse
T133 1845-1860 UBERON:0002108 denotes small intestine
T134 1865-1871 NCBITaxon:33208 denotes animal
T135 1900-1913 SO_EXT:polymorphism denotes polymorphisms
T136 1926-1931 SO_EXT:0000704 denotes genes
T137 1996-2003 SO_EXT:0000704 denotes genetic
T138 2024-2034 UBERON:0000160 denotes intestinal

craft-sa-dev

Id Subject Object Predicate Lexical cue
T160 0-10 sentence denotes Background
T161 0-10 NN denotes Background
T162 10-217 sentence denotes Although cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the severity of disease is highly variable indicating the influence of modifier genes.
T163 11-19 IN denotes Although
T164 39-45 VBN denotes caused
T165 20-26 JJ denotes cystic
T166 27-35 NN denotes fibrosis
T167 36-38 VBZ denotes is
T168 155-157 VBZ denotes is
T169 46-48 IN denotes by
T170 49-58 NNS denotes mutations
T171 59-61 IN denotes in
T172 62-65 DT denotes the
T173 125-129 NN denotes gene
T174 66-72 JJ denotes cystic
T175 108-117 NN denotes regulator
T176 73-81 NN denotes fibrosis
T177 82-95 JJ denotes transmembrane
T178 96-107 NN denotes conductance
T179 118-119 -LRB- denotes (
T180 119-123 NN denotes CFTR
T181 123-124 -RRB- denotes )
T182 129-131 , denotes ,
T183 131-134 DT denotes the
T184 135-143 NN denotes severity
T185 144-146 IN denotes of
T186 147-154 NN denotes disease
T187 158-164 RB denotes highly
T188 165-173 JJ denotes variable
T189 174-184 VBG denotes indicating
T190 185-188 DT denotes the
T191 189-198 NN denotes influence
T192 199-201 IN denotes of
T193 202-210 NN denotes modifier
T194 211-216 NNS denotes genes
T195 216-217 . denotes .
T196 217-420 sentence denotes The intestines of Cftr deficient mice (CF mice: Cftrtm1Unc) are prone to obstruction by excessive mucus accumulation and are used as a model of meconium ileus and distal intestinal obstruction syndrome.
T197 218-221 DT denotes The
T198 222-232 NNS denotes intestines
T199 278-281 VBP denotes are
T200 233-235 IN denotes of
T201 236-240 NN denotes Cftr
T202 241-250 JJ denotes deficient
T203 251-255 NNS denotes mice
T204 256-257 -LRB- denotes (
T205 257-259 NN denotes CF
T206 260-264 NNS denotes mice
T207 264-266 : denotes :
T208 266-276 NN denotes Cftrtm1Unc
T209 276-277 -RRB- denotes )
T210 282-287 JJ denotes prone
T211 288-290 IN denotes to
T212 291-302 NN denotes obstruction
T213 303-305 IN denotes by
T214 306-315 JJ denotes excessive
T215 322-334 NN denotes accumulation
T216 316-321 NN denotes mucus
T217 335-338 CC denotes and
T218 339-342 VBP denotes are
T219 343-347 VBN denotes used
T220 348-350 IN denotes as
T221 351-352 DT denotes a
T222 353-358 NN denotes model
T223 359-361 IN denotes of
T224 362-370 NN denotes meconium
T225 371-376 NN denotes ileus
T226 377-380 CC denotes and
T227 381-387 JJ denotes distal
T228 399-410 NN denotes obstruction
T229 388-398 JJ denotes intestinal
T230 411-419 NN denotes syndrome
T231 419-420 . denotes .
T232 420-496 sentence denotes This phenotype is strongly dependent on the genetic background of the mice.
T233 421-425 DT denotes This
T234 426-435 NN denotes phenotype
T235 436-438 VBZ denotes is
T236 439-447 RB denotes strongly
T237 448-457 JJ denotes dependent
T238 458-460 IN denotes on
T239 461-464 DT denotes the
T240 473-483 NN denotes background
T241 465-472 JJ denotes genetic
T242 484-486 IN denotes of
T243 487-490 DT denotes the
T244 491-495 NNS denotes mice
T245 495-496 . denotes .
T246 496-679 sentence denotes On the C57Bl/6 background, the majority of CF mice cannot survive on solid mouse chow, have inflammation of the small intestine, and are about 30% smaller than wild type littermates.
T247 497-499 IN denotes On
T248 555-562 VB denotes survive
T249 500-503 DT denotes the
T250 512-522 NN denotes background
T251 504-509 NN denotes C57Bl
T252 509-510 HYPH denotes /
T253 510-511 CD denotes 6
T254 522-524 , denotes ,
T255 524-527 DT denotes the
T256 528-536 NN denotes majority
T257 537-539 IN denotes of
T258 540-542 NN denotes CF
T259 543-547 NNS denotes mice
T260 548-551 MD denotes can
T261 551-554 RB denotes not
T262 563-565 IN denotes on
T263 566-571 JJ denotes solid
T264 578-582 NN denotes chow
T265 572-577 NN denotes mouse
T266 582-584 , denotes ,
T267 584-588 VBP denotes have
T268 589-601 NN denotes inflammation
T269 602-604 IN denotes of
T270 605-608 DT denotes the
T271 615-624 NN denotes intestine
T272 609-614 JJ denotes small
T273 624-626 , denotes ,
T274 626-629 CC denotes and
T275 630-633 VBP denotes are
T276 634-639 IN denotes about
T277 640-642 CD denotes 30
T278 642-643 NN denotes %
T279 644-651 JJR denotes smaller
T280 652-656 IN denotes than
T281 657-661 JJ denotes wild
T282 662-666 NN denotes type
T283 667-678 NNS denotes littermates
T284 678-679 . denotes .
T285 679-764 sentence denotes In this work potential modifier loci of the CF intestinal phenotype were identified.
T286 680-682 IN denotes In
T287 753-763 VBN denotes identified
T288 683-687 DT denotes this
T289 688-692 NN denotes work
T290 693-702 NN denotes potential
T291 712-716 NNS denotes loci
T292 703-711 NN denotes modifier
T293 717-719 IN denotes of
T294 720-723 DT denotes the
T295 738-747 NN denotes phenotype
T296 724-726 NN denotes CF
T297 727-737 JJ denotes intestinal
T298 748-752 VBD denotes were
T299 763-764 . denotes .
T300 764-773 sentence denotes Results
T301 766-773 NNS denotes Results
T302 773-953 sentence denotes CF mice on a mixed genetic background (95% C57Bl/6 and 5% 129Sv) were compared to CF mice congenic on the C57Bl/6 background for several parameters of the intestinal CF phenotype.
T303 774-776 NN denotes CF
T304 777-781 NNS denotes mice
T305 844-852 VBN denotes compared
T306 782-784 IN denotes on
T307 785-786 DT denotes a
T308 801-811 NN denotes background
T309 787-792 JJ denotes mixed
T310 793-800 JJ denotes genetic
T311 812-813 -LRB- denotes (
T312 817-822 NN denotes C57Bl
T313 813-815 CD denotes 95
T314 815-816 NN denotes %
T315 822-823 HYPH denotes /
T316 823-824 CD denotes 6
T317 825-828 CC denotes and
T318 829-830 CD denotes 5
T319 832-837 NN denotes 129Sv
T320 830-831 NN denotes %
T321 837-838 -RRB- denotes )
T322 839-843 VBD denotes were
T323 853-855 IN denotes to
T324 856-858 NN denotes CF
T325 859-863 NNS denotes mice
T326 864-872 JJ denotes congenic
T327 873-875 IN denotes on
T328 876-879 DT denotes the
T329 888-898 NN denotes background
T330 880-885 NN denotes C57Bl
T331 885-886 HYPH denotes /
T332 886-887 CD denotes 6
T333 899-902 IN denotes for
T334 903-910 JJ denotes several
T335 911-921 NNS denotes parameters
T336 922-924 IN denotes of
T337 925-928 DT denotes the
T338 943-952 NN denotes phenotype
T339 929-939 JJ denotes intestinal
T340 940-942 NN denotes CF
T341 952-953 . denotes .
T342 953-1236 sentence denotes CF mice on the mixed background exhibit significantly greater survival when fed dry mouse chow, have reduced intestinal inflammation as measured by quantitative RT-PCR for marker genes, have near normal body weight gain, and have reduced mucus accumulation in the intestinal crypts.
T343 954-956 NN denotes CF
T344 957-961 NNS denotes mice
T345 986-993 VBP denotes exhibit
T346 962-964 IN denotes on
T347 965-968 DT denotes the
T348 975-985 NN denotes background
T349 969-974 JJ denotes mixed
T350 994-1007 RB denotes significantly
T351 1008-1015 JJR denotes greater
T352 1016-1024 NN denotes survival
T353 1025-1029 WRB denotes when
T354 1030-1033 VBN denotes fed
T355 1034-1037 JJ denotes dry
T356 1044-1048 NN denotes chow
T357 1038-1043 NN denotes mouse
T358 1048-1050 , denotes ,
T359 1050-1054 VBP denotes have
T360 1055-1062 VBN denotes reduced
T361 1074-1086 NN denotes inflammation
T362 1063-1073 JJ denotes intestinal
T363 1087-1089 IN denotes as
T364 1090-1098 VBN denotes measured
T365 1099-1101 IN denotes by
T366 1102-1114 JJ denotes quantitative
T367 1118-1121 NN denotes PCR
T368 1115-1117 NN denotes RT
T369 1117-1118 HYPH denotes -
T370 1122-1125 IN denotes for
T371 1126-1132 NN denotes marker
T372 1133-1138 NNS denotes genes
T373 1138-1140 , denotes ,
T374 1140-1144 VBP denotes have
T375 1145-1149 RB denotes near
T376 1150-1156 JJ denotes normal
T377 1169-1173 NN denotes gain
T378 1157-1161 NN denotes body
T379 1162-1168 NN denotes weight
T380 1173-1175 , denotes ,
T381 1175-1178 CC denotes and
T382 1179-1183 VBP denotes have
T383 1184-1191 VBN denotes reduced
T384 1198-1210 NN denotes accumulation
T385 1192-1197 NN denotes mucus
T386 1211-1213 IN denotes in
T387 1214-1217 DT denotes the
T388 1229-1235 NNS denotes crypts
T389 1218-1228 JJ denotes intestinal
T390 1235-1236 . denotes .
T391 1236-1459 sentence denotes There was an indication of a gender effect for body weight gain: males did not show a significant improvement at 4 weeks of age, but were of normal weight at 8 weeks, while females showed improvement at both 4 and 8 weeks.
T392 1237-1242 EX denotes There
T393 1243-1246 VBD denotes was
T394 1316-1320 VB denotes show
T395 1247-1249 DT denotes an
T396 1250-1260 NN denotes indication
T397 1261-1263 IN denotes of
T398 1264-1265 DT denotes a
T399 1273-1279 NN denotes effect
T400 1266-1272 NN denotes gender
T401 1280-1283 IN denotes for
T402 1284-1288 NN denotes body
T403 1296-1300 NN denotes gain
T404 1289-1295 NN denotes weight
T405 1300-1302 : denotes :
T406 1302-1307 NNS denotes males
T407 1308-1311 VBD denotes did
T408 1312-1315 RB denotes not
T409 1321-1322 DT denotes a
T410 1335-1346 NN denotes improvement
T411 1323-1334 JJ denotes significant
T412 1347-1349 IN denotes at
T413 1350-1351 CD denotes 4
T414 1352-1357 NNS denotes weeks
T415 1358-1360 IN denotes of
T416 1361-1364 NN denotes age
T417 1364-1366 , denotes ,
T418 1366-1369 CC denotes but
T419 1370-1374 VBD denotes were
T420 1375-1377 IN denotes of
T421 1378-1384 JJ denotes normal
T422 1385-1391 NN denotes weight
T423 1392-1394 IN denotes at
T424 1395-1396 CD denotes 8
T425 1397-1402 NNS denotes weeks
T426 1402-1404 , denotes ,
T427 1404-1409 IN denotes while
T428 1418-1424 VBD denotes showed
T429 1410-1417 NNS denotes females
T430 1425-1436 NN denotes improvement
T431 1437-1439 IN denotes at
T432 1440-1444 CC denotes both
T433 1445-1446 CD denotes 4
T434 1453-1458 NNS denotes weeks
T435 1447-1450 CC denotes and
T436 1451-1452 CD denotes 8
T437 1458-1459 . denotes .
T438 1459-1590 sentence denotes By a preliminary genome-wide PCR allele scanning, three regions were found to be potentially associated with the milder phenotype.
T439 1460-1462 IN denotes By
T440 1529-1534 VBN denotes found
T441 1463-1464 DT denotes a
T442 1500-1508 NN denotes scanning
T443 1465-1476 JJ denotes preliminary
T444 1477-1483 NN denotes genome
T445 1484-1488 JJ denotes wide
T446 1483-1484 HYPH denotes -
T447 1489-1492 NN denotes PCR
T448 1493-1499 NN denotes allele
T449 1508-1510 , denotes ,
T450 1510-1515 CD denotes three
T451 1516-1523 NNS denotes regions
T452 1524-1528 VBD denotes were
T453 1535-1537 TO denotes to
T454 1553-1563 VBN denotes associated
T455 1538-1540 VB denotes be
T456 1541-1552 RB denotes potentially
T457 1564-1568 IN denotes with
T458 1569-1572 DT denotes the
T459 1580-1589 NN denotes phenotype
T460 1573-1579 JJR denotes milder
T461 1589-1590 . denotes .
T462 1590-1720 sentence denotes One on chr.1, defined by marker D1Mit36, one on chr. 9 defined by marker D9Mit90, and one on chr. 10, defined by marker D10Mit14.
T463 1591-1594 CD denotes One
T464 1595-1597 IN denotes on
T465 1598-1603 NN denotes chr.1
T466 1603-1605 , denotes ,
T467 1605-1612 VBN denotes defined
T468 1613-1615 IN denotes by
T469 1616-1622 NN denotes marker
T470 1623-1630 NN denotes D1Mit36
T471 1630-1632 , denotes ,
T472 1632-1635 CD denotes one
T473 1636-1638 IN denotes on
T474 1639-1643 NN denotes chr.
T475 1644-1645 CD denotes 9
T476 1646-1653 VBN denotes defined
T477 1654-1656 IN denotes by
T478 1657-1663 NN denotes marker
T479 1664-1671 NN denotes D9Mit90
T480 1671-1673 , denotes ,
T481 1673-1676 CC denotes and
T482 1677-1680 CD denotes one
T483 1681-1683 IN denotes on
T484 1684-1688 NN denotes chr.
T485 1689-1691 CD denotes 10
T486 1691-1693 , denotes ,
T487 1693-1700 VBN denotes defined
T488 1701-1703 IN denotes by
T489 1704-1710 NN denotes marker
T490 1711-1719 NN denotes D10Mit14
T491 1719-1720 . denotes .
T492 1720-1732 sentence denotes Conclusion
T493 1722-1732 NN denotes Conclusion
T494 1732-1881 sentence denotes Potential modifier regions were found that have a positive impact on the inflammatory phenotype of the CF mouse small intestine and animal survival.
T495 1733-1742 JJ denotes Potential
T496 1752-1759 NNS denotes regions
T497 1743-1751 NN denotes modifier
T498 1765-1770 VBN denotes found
T499 1760-1764 VBD denotes were
T500 1771-1775 WDT denotes that
T501 1776-1780 VBP denotes have
T502 1781-1782 DT denotes a
T503 1792-1798 NN denotes impact
T504 1783-1791 JJ denotes positive
T505 1799-1801 IN denotes on
T506 1802-1805 DT denotes the
T507 1819-1828 NN denotes phenotype
T508 1806-1818 JJ denotes inflammatory
T509 1829-1831 IN denotes of
T510 1832-1835 DT denotes the
T511 1851-1860 NN denotes intestine
T512 1836-1838 NN denotes CF
T513 1839-1844 NN denotes mouse
T514 1845-1850 JJ denotes small
T515 1861-1864 CC denotes and
T516 1865-1871 NN denotes animal
T517 1872-1880 NN denotes survival
T518 1880-1881 . denotes .
T519 1881-2045 sentence denotes Identification of polymorphisms in specific genes in these regions should provide important new information about genetic modifiers of the CF intestinal phenotype.
T520 1882-1896 NN denotes Identification
T521 1956-1963 VB denotes provide
T522 1897-1899 IN denotes of
T523 1900-1913 NNS denotes polymorphisms
T524 1914-1916 IN denotes in
T525 1917-1925 JJ denotes specific
T526 1926-1931 NNS denotes genes
T527 1932-1934 IN denotes in
T528 1935-1940 DT denotes these
T529 1941-1948 NNS denotes regions
T530 1949-1955 MD denotes should
T531 1964-1973 JJ denotes important
T532 1978-1989 NN denotes information
T533 1974-1977 JJ denotes new
T534 1990-1995 IN denotes about
T535 1996-2003 JJ denotes genetic
T536 2004-2013 NNS denotes modifiers
T537 2014-2016 IN denotes of
T538 2017-2020 DT denotes the
T539 2035-2044 NN denotes phenotype
T540 2021-2023 NN denotes CF
T541 2024-2034 JJ denotes intestinal
T542 2044-2045 . denotes .
R79 T227 T228 amod distal,obstruction
R18 T163 T164 mark Although,caused
R19 T164 T168 advcl caused,is
R23 T169 T164 agent by,caused
R24 T170 T169 pobj mutations,by
R25 T171 T170 prep in,mutations
R26 T172 T173 det the,gene
R27 T173 T171 pobj gene,in
R29 T175 T173 nmod regulator,gene
R30 T176 T175 nmod fibrosis,regulator
R31 T177 T175 amod transmembrane,regulator
R32 T178 T175 nmod conductance,regulator
R36 T182 T168 punct ", ",is
R37 T183 T184 det the,severity
R38 T184 T168 nsubj severity,is
R39 T185 T184 prep of,severity
R40 T186 T185 pobj disease,of
R41 T187 T188 advmod highly,variable
R42 T188 T168 acomp variable,is
R43 T189 T168 advcl indicating,is
R44 T190 T191 det the,influence
R45 T191 T189 dobj influence,indicating
R46 T192 T191 prep of,influence
R47 T193 T194 compound modifier,genes
R48 T194 T192 pobj genes,of
R49 T195 T168 punct .,is
R50 T197 T198 det The,intestines
R51 T198 T199 nsubj intestines,are
R52 T200 T198 prep of,intestines
R53 T201 T202 npadvmod Cftr,deficient
R54 T202 T203 amod deficient,mice
R55 T203 T200 pobj mice,of
R56 T204 T203 punct (,mice
R57 T205 T206 compound CF,mice
R58 T206 T203 appos mice,mice
R59 T207 T206 punct : ,mice
R60 T208 T206 appos Cftrtm1Unc,mice
R61 T209 T199 punct ),are
R62 T210 T199 acomp prone,are
R63 T211 T210 prep to,prone
R64 T212 T211 pobj obstruction,to
R65 T213 T212 prep by,obstruction
R66 T214 T215 amod excessive,accumulation
R67 T215 T213 pobj accumulation,by
R69 T217 T199 cc and,are
R70 T218 T219 auxpass are,used
R71 T219 T199 conj used,are
R72 T220 T219 prep as,used
R73 T221 T222 det a,model
R74 T222 T220 pobj model,as
R75 T223 T222 prep of,model
R76 T224 T225 compound meconium,ileus
R77 T225 T223 pobj ileus,of
R78 T226 T225 cc and,ileus
R80 T228 T230 compound obstruction,syndrome
R82 T230 T225 conj syndrome,ileus
R83 T231 T199 punct .,are
R84 T233 T234 det This,phenotype
R85 T234 T235 nsubj phenotype,is
R86 T236 T237 advmod strongly,dependent
R87 T237 T235 acomp dependent,is
R88 T238 T237 prep on,dependent
R89 T239 T240 det the,background
R90 T240 T238 pobj background,on
R92 T242 T240 prep of,background
R93 T243 T244 det the,mice
R94 T244 T242 pobj mice,of
R95 T245 T235 punct .,is
R96 T247 T248 prep On,survive
R97 T249 T250 det the,background
R98 T250 T247 pobj background,On
R102 T254 T248 punct ", ",survive
R103 T255 T256 det the,majority
R104 T256 T248 nsubj majority,survive
R105 T257 T256 prep of,majority
R106 T258 T259 compound CF,mice
R107 T259 T257 pobj mice,of
R108 T260 T248 aux can,survive
R109 T261 T248 neg not,survive
R110 T262 T248 prep on,survive
R111 T263 T264 amod solid,chow
R112 T264 T262 pobj chow,on
R114 T266 T248 punct ", ",survive
R115 T267 T248 conj have,survive
R116 T268 T267 dobj inflammation,have
R117 T269 T268 prep of,inflammation
R118 T270 T271 det the,intestine
R119 T271 T269 pobj intestine,of
R121 T273 T267 punct ", ",have
R122 T274 T267 cc and,have
R123 T275 T267 conj are,have
R124 T276 T277 quantmod about,30
R125 T277 T278 nummod 30,%
R126 T278 T279 npadvmod %,smaller
R127 T279 T275 acomp smaller,are
R128 T280 T279 prep than,smaller
R129 T281 T282 amod wild,type
R130 T282 T283 compound type,littermates
R131 T283 T280 pobj littermates,than
R132 T284 T248 punct .,survive
R133 T286 T287 prep In,identified
R134 T288 T289 det this,work
R135 T289 T286 pobj work,In
R136 T290 T291 compound potential,loci
R137 T291 T287 nsubjpass loci,identified
R139 T293 T291 prep of,loci
R140 T294 T295 det the,phenotype
R141 T295 T293 pobj phenotype,of
R144 T298 T287 auxpass were,identified
R145 T299 T287 punct .,identified
R146 T303 T304 compound CF,mice
R147 T304 T305 nsubjpass mice,compared
R148 T306 T304 prep on,mice
R149 T307 T308 det a,background
R150 T308 T306 pobj background,on
R153 T311 T312 punct (,C57Bl
R154 T312 T304 parataxis C57Bl,mice
R157 T315 T312 punct /,C57Bl
R158 T316 T312 nummod 6,C57Bl
R159 T317 T312 cc and,C57Bl
R160 T318 T319 nummod 5,129Sv
R161 T319 T312 conj 129Sv,C57Bl
R163 T321 T312 punct ),C57Bl
R164 T322 T305 auxpass were,compared
R165 T323 T305 prep to,compared
R166 T324 T325 compound CF,mice
R167 T325 T323 pobj mice,to
R168 T326 T325 amod congenic,mice
R169 T327 T326 prep on,congenic
R170 T328 T329 det the,background
R171 T329 T327 pobj background,on
R175 T333 T305 prep for,compared
R176 T334 T335 amod several,parameters
R177 T335 T333 pobj parameters,for
R178 T336 T335 prep of,parameters
R179 T337 T338 det the,phenotype
R180 T338 T336 pobj phenotype,of
R183 T341 T305 punct .,compared
R184 T343 T344 compound CF,mice
R185 T344 T345 nsubj mice,exhibit
R186 T346 T344 prep on,mice
R187 T347 T348 det the,background
R188 T348 T346 pobj background,on
R190 T350 T351 advmod significantly,greater
R191 T351 T352 amod greater,survival
R192 T352 T345 dobj survival,exhibit
R193 T353 T354 advmod when,fed
R194 T354 T345 advcl fed,exhibit
R195 T355 T356 amod dry,chow
R196 T356 T354 dobj chow,fed
R198 T358 T345 punct ", ",exhibit
R199 T359 T345 conj have,exhibit
R200 T360 T361 amod reduced,inflammation
R201 T361 T359 dobj inflammation,have
R203 T363 T364 mark as,measured
R204 T364 T359 advcl measured,have
R205 T365 T364 prep by,measured
R206 T366 T367 amod quantitative,PCR
R207 T367 T365 pobj PCR,by
R210 T370 T367 prep for,PCR
R211 T371 T372 compound marker,genes
R212 T372 T370 pobj genes,for
R213 T373 T359 punct ", ",have
R214 T374 T359 conj have,have
R215 T375 T376 advmod near,normal
R216 T376 T377 amod normal,gain
R217 T377 T374 dobj gain,have
R220 T380 T374 punct ", ",have
R221 T381 T374 cc and,have
R222 T382 T374 conj have,have
R223 T383 T384 amod reduced,accumulation
R224 T384 T382 dobj accumulation,have
R226 T386 T382 prep in,have
R227 T387 T388 det the,crypts
R228 T388 T386 pobj crypts,in
R230 T390 T345 punct .,exhibit
R231 T392 T393 expl There,was
R232 T393 T394 ccomp was,show
R233 T395 T396 det an,indication
R234 T396 T393 attr indication,was
R235 T397 T396 prep of,indication
R236 T398 T399 det a,effect
R237 T399 T397 pobj effect,of
R239 T401 T399 prep for,effect
R240 T402 T403 compound body,gain
R241 T403 T401 pobj gain,for
R243 T405 T394 punct : ,show
R244 T406 T394 nsubj males,show
R245 T407 T394 aux did,show
R246 T408 T394 neg not,show
R247 T409 T410 det a,improvement
R248 T410 T394 dobj improvement,show
R250 T412 T394 prep at,show
R251 T413 T414 nummod 4,weeks
R252 T414 T412 pobj weeks,at
R253 T415 T414 prep of,weeks
R254 T416 T415 pobj age,of
R255 T417 T394 punct ", ",show
R256 T418 T394 cc but,show
R257 T419 T394 conj were,show
R258 T420 T419 prep of,were
R259 T421 T422 amod normal,weight
R260 T422 T420 pobj weight,of
R261 T423 T419 prep at,were
R262 T424 T425 nummod 8,weeks
R263 T425 T423 pobj weeks,at
R264 T426 T394 punct ", ",show
R265 T427 T428 mark while,showed
R266 T428 T394 advcl showed,show
R268 T430 T428 dobj improvement,showed
R269 T431 T428 prep at,showed
R270 T432 T433 preconj both,4
R271 T433 T434 nummod 4,weeks
R272 T434 T431 pobj weeks,at
R275 T437 T394 punct .,show
R276 T439 T440 prep By,found
R277 T441 T442 det a,scanning
R278 T442 T439 pobj scanning,By
R281 T445 T442 amod wide,scanning
R282 T446 T445 punct -,wide
R285 T449 T440 punct ", ",found
R286 T450 T451 nummod three,regions
R287 T451 T440 nsubjpass regions,found
R288 T452 T440 auxpass were,found
R289 T453 T454 aux to,associated
R290 T454 T440 xcomp associated,found
R293 T457 T454 prep with,associated
R294 T458 T459 det the,phenotype
R295 T459 T457 pobj phenotype,with
R297 T461 T440 punct .,found
R298 T464 T463 prep on,One
R299 T465 T464 pobj chr.1,on
R300 T466 T463 punct ", ",One
R301 T467 T463 acl defined,One
R302 T468 T467 prep by,defined
R303 T469 T470 compound marker,D1Mit36
R304 T470 T468 pobj D1Mit36,by
R305 T471 T463 punct ", ",One
R306 T472 T463 conj one,One
R307 T473 T472 prep on,one
R308 T474 T473 pobj chr.,on
R309 T475 T474 nummod 9,chr.
R310 T476 T472 acl defined,one
R311 T477 T476 prep by,defined
R312 T478 T479 compound marker,D9Mit90
R313 T479 T477 pobj D9Mit90,by
R314 T480 T472 punct ", ",one
R315 T481 T472 cc and,one
R316 T482 T472 conj one,one
R317 T483 T482 prep on,one
R318 T484 T483 pobj chr.,on
R319 T485 T484 nummod 10,chr.
R320 T486 T482 punct ", ",one
R321 T487 T482 acl defined,one
R322 T488 T487 prep by,defined
R323 T489 T490 compound marker,D10Mit14
R324 T490 T488 pobj D10Mit14,by
R325 T491 T482 punct .,one
R326 T495 T496 amod Potential,regions
R327 T496 T498 nsubjpass regions,found
R329 T499 T498 auxpass were,found
R330 T500 T501 dep that,have
R331 T501 T498 ccomp have,found
R332 T502 T503 det a,impact
R333 T503 T501 dobj impact,have
R335 T505 T501 prep on,have
R336 T506 T507 det the,phenotype
R337 T507 T505 pobj phenotype,on
R339 T509 T507 prep of,phenotype
R340 T510 T511 det the,intestine
R341 T511 T509 pobj intestine,of
R345 T515 T507 cc and,phenotype
R346 T516 T517 compound animal,survival
R347 T517 T507 conj survival,phenotype
R348 T518 T498 punct .,found
R349 T520 T521 nsubj Identification,provide
R350 T522 T520 prep of,Identification
R351 T523 T522 pobj polymorphisms,of
R352 T524 T520 prep in,Identification
R353 T525 T526 amod specific,genes
R354 T526 T524 pobj genes,in
R355 T527 T526 prep in,genes
R356 T528 T529 det these,regions
R357 T529 T527 pobj regions,in
R358 T530 T521 aux should,provide
R359 T531 T532 amod important,information
R360 T532 T521 dobj information,provide
R362 T534 T532 prep about,information
R363 T535 T536 amod genetic,modifiers
R364 T536 T534 pobj modifiers,about
R365 T537 T536 prep of,modifiers
R366 T538 T539 det the,phenotype
R367 T539 T537 pobj phenotype,of
R370 T542 T521 punct .,provide
R20 T165 T166 amod cystic,fibrosis
R21 T166 T164 nsubjpass fibrosis,caused
R22 T167 T164 auxpass is,caused
R28 T174 T175 amod cystic,regulator
R33 T179 T175 punct (,regulator
R34 T180 T175 appos CFTR,regulator
R35 T181 T173 punct ),gene
R68 T216 T215 compound mucus,accumulation
R81 T229 T228 amod intestinal,obstruction
R91 T241 T240 amod genetic,background
R99 T251 T250 nmod C57Bl,background
R100 T252 T251 punct /,C57Bl
R101 T253 T251 nummod 6,C57Bl
R113 T265 T264 compound mouse,chow
R120 T272 T271 amod small,intestine
R138 T292 T291 compound modifier,loci
R142 T296 T295 nmod CF,phenotype
R143 T297 T295 amod intestinal,phenotype
R151 T309 T308 amod mixed,background
R152 T310 T308 amod genetic,background
R155 T313 T312 nummod 95,C57Bl
R156 T314 T313 quantmod %,95
R162 T320 T318 quantmod %,5
R172 T330 T329 nmod C57Bl,background
R173 T331 T330 punct /,C57Bl
R174 T332 T330 nummod 6,C57Bl
R181 T339 T338 amod intestinal,phenotype
R182 T340 T338 compound CF,phenotype
R189 T349 T348 amod mixed,background
R197 T357 T356 compound mouse,chow
R202 T362 T361 amod intestinal,inflammation
R208 T368 T367 compound RT,PCR
R209 T369 T367 punct -,PCR
R218 T378 T379 compound body,weight
R219 T379 T377 compound weight,gain
R225 T385 T384 compound mucus,accumulation
R229 T389 T388 amod intestinal,crypts
R238 T400 T399 compound gender,effect
R242 T404 T403 compound weight,gain
R249 T411 T410 amod significant,improvement
R267 T429 T428 nsubj females,showed
R273 T435 T433 cc and,4
R274 T436 T433 conj 8,4
R279 T443 T442 amod preliminary,scanning
R280 T444 T445 npadvmod genome,wide
R283 T447 T448 compound PCR,allele
R284 T448 T442 compound allele,scanning
R291 T455 T454 auxpass be,associated
R292 T456 T454 advmod potentially,associated
R296 T460 T459 amod milder,phenotype
R328 T497 T496 compound modifier,regions
R334 T504 T503 amod positive,impact
R338 T508 T507 amod inflammatory,phenotype
R342 T512 T513 nmod CF,mouse
R343 T513 T511 nmod mouse,intestine
R344 T514 T511 amod small,intestine
R361 T533 T532 amod new,information
R368 T540 T539 nmod CF,phenotype
R369 T541 T539 amod intestinal,phenotype