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Id Subject Object Predicate Lexical cue
T7419 15704-15709 JJ denotes mixed
T7418 15700-15703 CC denotes and
T7417 15697-15699 NN denotes B6
T7416 15710-15721 NNS denotes backgrounds
T7415 15693-15696 DT denotes the
T7414 15690-15692 IN denotes on
T7413 15676-15689 NNS denotes heterozygotes
T7412 15671-15675 NN denotes Cftr
T7411 15662-15670 VBG denotes breeding
T7410 15657-15661 IN denotes from
T7409 15647-15656 NN denotes offspring
T7408 15642-15646 JJ denotes male
T7407 15639-15641 IN denotes in
T7406 15629-15638 NNS denotes genotypes
T7405 15624-15628 NN denotes Cftr
T7404 15621-15623 IN denotes of
T7403 15608-15620 NN denotes Distribution
T7364 17485-17486 . denotes .
T7363 17484-17485 -RRB- denotes )
T7362 17476-17477 SYM denotes <
T7361 17474-17475 NN denotes P
T7360 17478-17484 CD denotes 0.0005
T7359 17473-17474 -LRB- denotes (
T7358 17468-17472 NN denotes type
T7357 17463-17467 JJ denotes wild
T7356 17458-17462 IN denotes than
T7355 17450-17457 JJR denotes earlier
T7354 17436-17449 RB denotes significantly
T7353 17426-17430 RB denotes also
T7352 17412-17414 NN denotes B6
T7351 17415-17425 NN denotes background
T7350 17408-17411 DT denotes the
T7349 17405-17407 IN denotes on
T7348 17431-17435 VBD denotes died
T7347 17400-17404 NNS denotes mice
T7346 17397-17399 NN denotes CF
T7345 17396-17486 sentence denotes CF mice on the B6 background also died significantly earlier than wild type (P < 0.0005).
T7344 17395-17396 . denotes .
T7343 17394-17395 -RRB- denotes )
T7342 17387-17388 SYM denotes =
T7341 17385-17386 NN denotes P
T7340 17389-17394 CD denotes 0.025
T7339 17384-17385 -LRB- denotes (
T7338 17370-17372 NN denotes B6
T7337 17373-17383 NN denotes background
T7336 17366-17369 DT denotes the
T7335 17363-17365 IN denotes on
T7334 17358-17362 NNS denotes mice
T7333 17355-17357 NN denotes CF
T7332 17350-17354 IN denotes than
T7331 17338-17343 JJR denotes later
T7330 17344-17349 NN denotes death
T7329 17324-17337 RB denotes significantly
T7328 17320-17323 CC denotes and
T7327 17318-17320 , denotes ,
T7326 17317-17318 -RRB- denotes )
T7325 17310-17311 SYM denotes =
T7324 17308-17309 NN denotes P
T7323 17312-17317 CD denotes 0.035
T7322 17307-17308 -LRB- denotes (
T7321 17302-17306 NN denotes type
T7320 17297-17301 JJ denotes wild
T7319 17294-17296 IN denotes to
T7318 17285-17293 VBN denotes compared
T7317 17279-17284 NN denotes death
T7316 17271-17278 JJR denotes earlier
T7315 17257-17270 RB denotes significantly
T7314 17236-17241 JJ denotes mixed
T7313 17242-17252 NN denotes background
T7312 17232-17235 DT denotes the
T7311 17229-17231 IN denotes on
T7310 17224-17228 NNS denotes mice
T7309 17221-17223 NN denotes CF
T7308 17219-17221 , denotes ,
T7307 17215-17219 NN denotes test
T7306 17209-17210 HYPH denotes -
T7305 17210-17214 NN denotes rank
T7304 17206-17209 NN denotes log
T7303 17253-17256 VBD denotes had
T7302 17203-17205 IN denotes By
T7301 17202-17396 sentence denotes By log-rank test, CF mice on the mixed background had significantly earlier death compared to wild type (P = 0.035), and significantly later death than CF mice on the B6 background (P = 0.025).
T7300 17201-17202 . denotes .
T7299 17187-17197 JJ denotes subsequent
T7298 17198-17201 NN denotes day
T7297 17183-17186 DT denotes the
T7296 17180-17182 IN denotes as
T7295 17169-17170 '' denotes '
T7294 17164-17169 NN denotes death
T7293 17171-17179 VBN denotes recorded
T7292 17163-17164 `` denotes '
T7291 17159-17162 CC denotes and
T7290 17143-17147 VBD denotes were
T7289 17134-17142 NN denotes distress
T7288 17126-17133 JJ denotes obvious
T7287 17123-17125 IN denotes in
T7286 17148-17158 VBN denotes sacrificed
T7285 17118-17122 NNS denotes mice
T7284 17114-17117 CC denotes and
T7283 17100-17104 PRP denotes they
T7282 17105-17113 VBD denotes occurred
T7281 17097-17099 IN denotes as
T7280 17083-17087 VBD denotes were
T7279 17088-17096 VBN denotes recorded
T7278 17076-17082 NNS denotes Deaths
T7277 17075-17202 sentence denotes Deaths were recorded as they occurred and mice in obvious distress were sacrificed and 'death' recorded as the subsequent day.
T7276 17074-17075 . denotes .
T7275 17058-17068 JJ denotes additional
T7274 17069-17074 NNS denotes weeks
T7273 17053-17055 IN denotes to
T7272 17056-17057 CD denotes 8
T7271 17050-17052 IN denotes up
T7270 17046-17049 IN denotes for
T7269 17035-17040 NN denotes mouse
T7268 17029-17034 JJ denotes solid
T7267 17041-17045 NN denotes chow
T7266 17020-17028 JJ denotes standard
T7265 17011-17015 VBD denotes were
T7264 17006-17010 PRP denotes they
T7263 17001-17005 NN denotes time
T7262 16995-17000 WDT denotes which
T7261 17016-17019 VBN denotes fed
T7260 16992-16994 IN denotes at
T7259 16990-16992 , denotes ,
T7258 16987-16990 NN denotes age
T7257 16984-16986 IN denotes of
T7256 16978-16983 NNS denotes weeks
T7255 16976-16977 CD denotes 8
T7254 16970-16975 IN denotes until
T7253 16968-16969 -RRB- denotes )
T7252 16960-16968 NNP denotes Peptamen
T6564 27642-27643 . denotes .
T6563 27631-27642 JJ denotes significant
T6562 27616-27619 VBD denotes was
T6561 27611-27615 CD denotes 0.05
T6560 27609-27610 SYM denotes <
T6559 27607-27608 NN denotes P
T6558 27605-27607 , denotes ,
T6557 27588-27599 JJ denotes statistical
T6556 27600-27605 NNS denotes tests
T6555 27584-27587 DT denotes all
T6554 27620-27630 VBN denotes considered
T6553 27580-27583 IN denotes For
T6552 27579-27643 sentence denotes For all statistical tests, P < 0.05 was considered significant.
T6551 27578-27579 . denotes .
T6550 27570-27578 NN denotes analysis
T6549 27562-27563 HYPH denotes -
T6548 27563-27569 NN denotes square
T6547 27559-27562 NN denotes Chi
T6546 27553-27558 VBG denotes using
T6545 27544-27552 NN denotes genetics
T6544 27534-27543 JJ denotes Mendelian
T6543 27531-27533 IN denotes by
T6542 27522-27530 VBN denotes expected
T6541 27517-27521 DT denotes that
T6540 27514-27516 IN denotes to
T6539 27500-27504 VBD denotes were
T6538 27493-27494 -RRB- denotes )
T6537 27492-27493 SYM denotes -
T6536 27491-27492 HYPH denotes /
T6535 27490-27491 SYM denotes +
T6534 27489-27490 -LRB- denotes (
T6533 27485-27489 NN denotes Cftr
T6532 27495-27499 NNS denotes mice
T6531 27476-27484 VBG denotes breeding
T6530 27471-27475 IN denotes from
T6529 27463-27470 VBG denotes weaning
T6528 27460-27462 IN denotes to
T6527 27450-27459 VBG denotes surviving
T6526 27445-27449 NNS denotes pups
T6525 27442-27444 IN denotes of
T6524 27432-27441 NNS denotes genotypes
T6523 27429-27431 IN denotes of
T6522 27505-27513 VBN denotes compared
T6521 27415-27428 NNS denotes distributions
T6520 27411-27414 DT denotes The
T6519 27410-27579 sentence denotes The distributions of genotypes of pups surviving to weaning from breeding Cftr(+/-) mice were compared to that expected by Mendelian genetics using Chi-square analysis.
T6518 27409-27410 . denotes .
T6517 27408-27409 -RRB- denotes )
T6516 27406-27408 , denotes ,
T6515 27393-27397 NN denotes PEPI
T6514 27398-27406 NN denotes software
T6476 27239-27243 NNS denotes data
T6475 27212-27222 NN denotes expression
T6474 27207-27211 NN denotes Gene
T6473 27206-27331 sentence denotes Gene expression and body weight data were compared by ANOVA with a post-hoc Tukey's analysis (Systat software, Chicago, IL).
T6472 27196-27206 NN denotes Statistics
T6452 27193-27194 . denotes .
T6451 27187-27193 NNS denotes mucins
T6450 27179-27186 JJ denotes neutral
T6449 27175-27178 IN denotes for
T6448 27173-27174 -RRB- denotes )
T6447 27169-27170 -LRB- denotes (
T6446 27166-27168 POS denotes 's
T6445 27170-27173 NN denotes PAS
T6444 27160-27166 NNP denotes Schiff
T6443 27155-27159 NN denotes acid
T6442 27146-27154 JJ denotes periodic
T6441 27141-27145 IN denotes with
T6440 27128-27132 VBD denotes were
T6439 27126-27127 -RRB- denotes )
T6438 27122-27123 CD denotes 5
T6437 27124-27126 NN denotes μm
T6436 27121-27122 -LRB- denotes (
T6435 27133-27140 VBN denotes stained
T6434 27112-27120 NNS denotes Sections
T6433 27111-27194 sentence denotes Sections (5 μm) were stained with periodic acid Schiff's (PAS) for neutral mucins.
T6432 27110-27111 . denotes .
T6431 27109-27110 -RRB- denotes )
T6430 27107-27109 NNP denotes VA
T6429 27105-27107 , denotes ,
T6428 27096-27105 NNP denotes Woodstock
T6427 27094-27096 , denotes ,
T6426 27090-27094 NNP denotes HSRL
T6425 27089-27090 -LRB- denotes (
T6424 27070-27080 JJ denotes commercial
T6423 27081-27088 NN denotes service
T6422 27068-27069 DT denotes a
T6421 27065-27067 IN denotes by
T6420 27054-27064 NN denotes sectioning
T6419 27050-27053 CC denotes and
T6418 27040-27049 NN denotes embedding
T6417 27031-27039 NN denotes paraffin
T6416 27027-27030 IN denotes for
T6415 27013-27017 RB denotes then
T6414 27008-27012 VBD denotes were
T6413 27018-27026 VBN denotes prepared
T6412 27000-27007 NNS denotes tissues
T6411 26996-26999 DT denotes The
T6410 26995-27111 sentence denotes The tissues were then prepared for paraffin embedding and sectioning by a commercial service (HSRL, Woodstock, VA).
T6409 26994-26995 . denotes .
T6408 26978-26994 NN denotes paraformaldehyde
T6407 26976-26977 NN denotes %
T6406 26975-26976 CD denotes 4
T6405 26972-26974 IN denotes in
T6404 26962-26971 RB denotes overnight
T6403 26956-26961 VBN denotes fixed
T6402 26946-26955 NN denotes immersion
T6401 26942-26945 CC denotes and
T6400 26926-26934 VBN denotes buffered
T6399 26935-26941 NN denotes saline
T6398 26916-26925 NN denotes phosphate
T6397 26911-26915 IN denotes with
T6396 26899-26902 VBD denotes was
T6395 26903-26910 VBN denotes flushed
T6394 26883-26888 JJ denotes small
T6393 26889-26898 NN denotes intestine
T6392 26879-26882 DT denotes The
T6391 26878-26995 sentence denotes The small intestine was flushed with phosphate buffered saline and immersion fixed overnight in 4% paraformaldehyde.
T6390 26869-26878 NN denotes Histology
T7251 16959-16960 -LRB- denotes (
T7250 16947-16953 NN denotes liquid
T7249 16954-16958 NN denotes diet
T7248 16943-16946 DT denotes the
T7247 16940-16942 IN denotes on
T7246 16924-16928 VBD denotes were
T7245 16929-16939 VBN denotes maintained
T7244 16919-16923 NNS denotes Mice
T7243 16918-17075 sentence denotes Mice were maintained on the liquid diet (Peptamen) until 8 weeks of age, at which time they were fed standard solid mouse chow for up to 8 additional weeks.
T7242 16917-16918 . denotes .
T7241 16913-16917 NN denotes chow
T7240 16907-16912 JJ denotes solid
T7239 16904-16906 IN denotes on
T7238 16889-16894 NN denotes mouse
T7237 16895-16903 NN denotes survival
T7236 16886-16888 NN denotes CF
T7235 16883-16885 IN denotes on
T7234 16872-16882 NN denotes background
T7233 16864-16871 JJ denotes genetic
T7232 16861-16863 IN denotes of
T7231 16854-16860 NN denotes Effect
T6375 26866-26867 . denotes .
T6374 26857-26858 -RRB- denotes )
T6373 26856-26857 SYM denotes '
T6372 26855-26856 CD denotes 3
T6371 26854-26855 HYPH denotes -
T6370 26848-26851 NN denotes CCA
T6369 26844-26847 NN denotes CTA
T6368 26840-26843 NN denotes TAT
T6367 26836-26839 NN denotes GTT
T6366 26832-26835 NN denotes GGT
T6365 26828-26831 NN denotes CAC
T6364 26827-26828 HYPH denotes -
T6363 26826-26827 SYM denotes '
T6362 26825-26826 CD denotes 5
T6361 26852-26854 NN denotes AC
T6360 26824-26825 -LRB- denotes (
T6359 26816-26823 JJ denotes reverse
T6358 26812-26815 CC denotes and
T6357 26810-26811 -RRB- denotes )
T6356 26809-26810 SYM denotes '
T6355 26808-26809 CD denotes 3
T6354 26807-26808 HYPH denotes -
T6353 26801-26804 NN denotes TGC
T6352 26797-26800 NN denotes CAC
T6351 26793-26796 NN denotes GGA
T6350 26789-26792 NN denotes GAT
T6349 26785-26788 NN denotes TTC
T6348 26781-26784 NN denotes GAC
T6347 26780-26781 HYPH denotes -
T6346 26779-26780 SYM denotes '
T6345 26778-26779 CD denotes 5
T6344 26805-26807 NN denotes TC
T6343 26777-26778 -LRB- denotes (
T6342 26769-26776 JJ denotes forward
T6341 26859-26866 NNS denotes primers
T6340 26765-26768 DT denotes the
T6339 26759-26764 VBG denotes using
T6338 26745-26749 RB denotes also
T6337 26741-26744 VBD denotes was
T6336 26739-26741 , denotes ,
T6335 26735-26739 NN denotes Muc2
T6334 26733-26735 , denotes ,
T6333 26717-26727 JJ denotes intestinal
T6332 26711-26716 JJ denotes major
T6331 26728-26733 NN denotes mucin
T6330 26707-26710 DT denotes the
T6329 26704-26706 IN denotes of
T6328 26750-26758 VBN denotes measured
T6327 26693-26703 NN denotes Expression
T6326 26692-26867 sentence denotes Expression of the major intestinal mucin, Muc2, was also measured using the forward (5'-GAC TTC GAT GGA CAC TGC TC-3') and reverse (5'-CAC GGT GTT TAT CTA CCA AC-3') primers.
T6325 26691-26692 . denotes .
T6324 26690-26691 -RRB- denotes ]
T6323 26688-26690 CD denotes 21
T6322 26687-26688 -LRB- denotes [
T6321 26671-26676 JJ denotes small
T6320 26665-26670 NN denotes mouse
T6319 26662-26664 NN denotes CF
T6318 26677-26686 NN denotes intestine
T6317 26658-26661 DT denotes the
T6316 26655-26657 IN denotes in
T6315 26643-26646 RB denotes not
T6314 26640-26642 VBZ denotes is
T6313 26622-26634 NN denotes housekeeping
T6312 26635-26639 NN denotes gene
T6311 26617-26621 DT denotes this
T6310 26614-26616 IN denotes of
T6309 26647-26654 VBN denotes altered
T6308 26603-26613 NN denotes expression
T6307 26599-26602 CC denotes and
T6306 26594-26598 NN denotes mRNA
T6305 26588-26593 NN denotes GAPDH
T6304 26585-26587 IN denotes to
T6303 26569-26573 VBD denotes were
T6302 26574-26584 VBN denotes normalized
T6301 26562-26568 NNS denotes Values
T6300 26561-26692 sentence denotes Values were normalized to GAPDH mRNA and expression of this housekeeping gene is not altered in the CF mouse small intestine [21].
T6299 26560-26561 . denotes .
T6298 26559-26560 -RRB- denotes ]
T6297 26557-26559 CD denotes 21
T6296 26556-26557 -LRB- denotes [
T6295 26538-26547 VBN denotes described
T6294 26527-26537 RB denotes previously
T6293 26548-26555 NNS denotes primers
T6292 26523-26526 DT denotes the
T6291 26517-26522 VBG denotes using
T6290 26511-26516 NNS denotes genes
T6289 26502-26510 JJ denotes specific
T6288 26499-26501 IN denotes of
T6287 26488-26498 NN denotes expression
T6286 26480-26487 VB denotes measure
T6285 26477-26479 TO denotes to
T6284 26468-26471 VBD denotes was
T6283 26472-26476 VBN denotes used
T6282 26463-26464 HYPH denotes -
T6281 26461-26463 NN denotes RT
T6280 26455-26456 HYPH denotes -
T6279 26456-26460 NN denotes time
T6278 26451-26455 JJ denotes real
T6277 26449-26451 , denotes ,
T6276 26464-26467 NN denotes PCR
T6275 26437-26449 JJ denotes Quantitative
T6274 26436-26561 sentence denotes Quantitative, real-time RT-PCR was used to measure expression of specific genes using the previously described primers [21].
T6273 26435-26436 . denotes .
T6272 26434-26435 -RRB- denotes ]
T6271 26432-26434 CD denotes 21
T6270 26431-26432 -LRB- denotes [
T6269 26410-26420 RB denotes previously
T6268 26421-26430 VBN denotes described
T6267 26407-26409 IN denotes as
T6266 26391-26396 JJ denotes small
T6265 26384-26390 JJ denotes entire
T6264 26397-26406 NN denotes intestine
T6263 26380-26383 DT denotes the
T6262 26375-26379 IN denotes from
T6261 26361-26364 VBD denotes was
T6255 26335-26339 NN denotes gene
T6254 26332-26334 IN denotes of
T6253 26320-26331 NN denotes Measurement
T6201 26317-26318 . denotes .
T6200 26299-26307 CD denotes nineteen
T6199 26308-26317 NNS denotes autosomes
T6198 26295-26298 DT denotes the
T6197 26290-26294 VBP denotes span
T6196 26286-26289 CC denotes and
T6195 26280-26285 RB denotes apart
T6194 26277-26279 NN denotes cM
T6193 26273-26274 SYM denotes –
T6192 26274-26276 CD denotes 13
T6191 26271-26273 CD denotes 12
T6190 26260-26263 VBP denotes are
T6189 26264-26270 VBN denotes spaced
T6188 26252-26259 NNS denotes markers
T6187 26248-26251 DT denotes The
T6186 26247-26318 sentence denotes The markers are spaced 12–13 cM apart and span the nineteen autosomes.
T6185 26246-26247 . denotes .
T6184 26235-26238 CD denotes 129
T6183 26231-26234 CC denotes and
T6182 26239-26246 NNS denotes strains
T6181 26228-26230 NN denotes B6
T6180 26220-26227 IN denotes between
T6179 26208-26219 VB denotes distinguish
T6178 26205-26207 TO denotes to
T6177 26196-26204 VBN denotes designed
T6176 26181-26187 VBN denotes mapped
T6175 26188-26195 NNS denotes markers
T6174 26177-26180 CD denotes 108
T6173 26174-26176 IN denotes of
T6172 26165-26173 VBZ denotes consists
T6171 26154-26158 NN denotes SSLP
T6170 26159-26164 NN denotes panel
T6169 26150-26153 DT denotes The
T6168 26149-26247 sentence denotes The SSLP panel consists of 108 mapped markers designed to distinguish between B6 and 129 strains.
T6167 26148-26149 . denotes .
T6166 26140-26147 NNS denotes alleles
T6165 26129-26132 CD denotes 129
T6164 26125-26128 CC denotes and
T6163 26133-26139 NN denotes strain
T6162 26122-26124 NN denotes B6
T6161 26118-26121 IN denotes for
T6160 26109-26117 JJ denotes specific
T6159 26096-26100 NN denotes DMit
T6513 27392-27393 -LRB- denotes (
T6512 27385-27391 NNS denotes values
T6511 27383-27384 NN denotes P
T6510 27379-27382 IN denotes for
T6509 27368-27369 HYPH denotes -
T6508 27369-27373 NN denotes rank
T6507 27365-27368 NN denotes log
T6506 27374-27378 NN denotes test
T6505 27363-27364 DT denotes a
T6504 27360-27362 IN denotes by
T6503 27346-27350 VBD denotes were
T6502 27351-27359 VBN denotes analyzed
T6501 27341-27345 NNS denotes data
T6500 27332-27340 NN denotes Survival
T6499 27331-27410 sentence denotes Survival data were analyzed by a log-rank test for P values (PEPI software, ).
T6498 27330-27331 . denotes .
T6497 27329-27330 -RRB- denotes )
T6496 27327-27329 NNP denotes IL
T6495 27325-27327 , denotes ,
T6494 27318-27325 NNP denotes Chicago
T6493 27316-27318 , denotes ,
T6492 27301-27307 NNP denotes Systat
T6491 27308-27316 NNP denotes software
T6490 27300-27301 -LRB- denotes (
T6489 27288-27290 POS denotes 's
T6488 27283-27288 NNP denotes Tukey
T6487 27274-27282 JJ denotes post-hoc
T6486 27291-27299 NN denotes analysis
T6485 27272-27273 DT denotes a
T6484 27267-27271 IN denotes with
T6483 27261-27266 NN denotes ANOVA
T6482 27258-27260 IN denotes by
T6481 27244-27248 VBD denotes were
T6480 27249-27257 VBN denotes compared
T6479 27232-27238 NN denotes weight
T6478 27227-27231 NN denotes body
T6477 27223-27226 CC denotes and
T6158 26101-26108 NNS denotes primers
T6157 26092-26095 DT denotes the
T6156 26087-26091 IN denotes with
T6155 26074-26077 NN denotes PCR
T6154 26072-26073 -RRB- denotes )
T6153 26068-26072 NN denotes SSLP
T6152 26067-26068 -LRB- denotes (
T6151 26078-26086 NN denotes analysis
T6150 26047-26053 NN denotes length
T6149 26038-26046 NN denotes sequence
T6148 26054-26066 NN denotes polymorphism
T6147 26031-26037 JJ denotes simple
T6146 26027-26030 IN denotes for
T6145 26008-26015 NNP denotes Jackson
T6144 26016-26026 NNP denotes Laboratory
T6143 26004-26007 DT denotes The
T6142 26001-26003 IN denotes to
T6141 25991-25995 VBD denotes were
T6140 25986-25990 NN denotes tail
T6139 25980-25985 NN denotes mouse
T6138 25977-25979 IN denotes of
T6137 25996-26000 VBN denotes sent
T6136 25970-25976 NNS denotes Pieces
T6135 25969-26149 sentence denotes Pieces of mouse tail were sent to The Jackson Laboratory for simple sequence length polymorphism (SSLP) PCR analysis with the DMit primers specific for B6 and 129 strain alleles .
T6134 25968-25969 . denotes .
T6133 25954-25963 JJ denotes interbred
T6132 25964-25968 NNS denotes mice
T6131 25950-25953 DT denotes the
T6130 25947-25949 IN denotes in
T6129 25935-25936 HYPH denotes /
T6128 25936-25938 NN denotes Sv
T6127 25932-25935 CD denotes 129
T6126 25928-25931 CC denotes and
T6125 25926-25927 CD denotes 6
T6124 25925-25926 HYPH denotes /
T6123 25939-25946 NNS denotes strains
T6122 25920-25925 NN denotes C57Bl
T6121 25917-25919 IN denotes of
T6120 25903-25916 NNS denotes contributions
T6119 25899-25902 DT denotes the
T6118 25889-25898 VB denotes determine
T6117 25886-25888 TO denotes to
T6116 25877-25880 VBD denotes was
T6115 25875-25876 -RRB- denotes )
T6114 25873-25875 NNP denotes ME
T6113 25871-25873 , denotes ,
T6112 25861-25864 NNP denotes Bar
T6111 25865-25871 NNP denotes Harbor
T6110 25860-25861 -LRB- denotes (
T6109 25841-25848 NNP denotes Jackson
T6108 25849-25859 NNP denotes Laboratory
T6107 25837-25840 DT denotes The
T6106 25834-25836 IN denotes of
T6105 25881-25885 VBN denotes used
T6104 25817-25825 NN denotes Scanning
T6103 25810-25816 NN denotes Genome
T6102 25826-25833 NN denotes Service
T6101 25806-25809 DT denotes The
T6100 25805-25969 sentence denotes The Genome Scanning Service of The Jackson Laboratory (Bar Harbor, ME) was used to determine the contributions of C57Bl/6 and 129/Sv strains in the interbred mice.
T6099 25792-25805 NN denotes determination
T6098 25781-25791 NN denotes background
T6097 25773-25780 JJ denotes Genetic
T6070 25770-25771 . denotes .
T6069 25765-25770 NNP denotes IACUC
T6068 25750-25757 NNP denotes Medical
T6067 25743-25749 NNP denotes Kansas
T6066 25740-25742 IN denotes of
T6065 25758-25764 NNP denotes Center
T6064 25729-25739 NNP denotes University
T6063 25725-25728 DT denotes the
T6062 25722-25724 IN denotes by
T6061 25708-25712 VBD denotes were
T6060 25713-25721 VBN denotes approved
T6059 25697-25707 NNS denotes procedures
T6058 25693-25696 DT denotes All
T6057 25692-25771 sentence denotes All procedures were approved by the University of Kansas Medical Center IACUC.
T6056 25691-25692 . denotes .
T6055 25686-25691 NNS denotes cages
T6054 25681-25682 HYPH denotes -
T6053 25682-25685 NN denotes top
T6052 25674-25681 NN denotes barrier
T6051 25671-25673 IN denotes in
T6050 25657-25661 JJ denotes free
T6049 25656-25657 HYPH denotes -
T6048 25648-25656 NN denotes pathogen
T6047 25639-25647 JJ denotes specific
T6046 25662-25670 NN denotes facility
T6045 25637-25638 DT denotes a
T6044 25634-25636 IN denotes in
T6043 25624-25628 VBD denotes were
T6042 25629-25633 VBN denotes kept
T6041 25619-25623 NNS denotes Mice
T6040 25618-25692 sentence denotes Mice were kept in a specific pathogen-free facility in barrier-top cages.
T5933 25102-25103 -LRB- denotes [
T5932 25081-25091 RB denotes previously
T5931 25092-25101 VBN denotes described
T5930 25078-25080 IN denotes as
T5929 25074-25077 NN denotes PCR
T5928 25071-25073 IN denotes by
T5927 25067-25070 NN denotes age
T5926 25064-25066 IN denotes of
T5925 25058-25063 NNS denotes weeks
T5924 25056-25057 CD denotes 2
T5923 25053-25055 IN denotes at
T5922 25038-25042 VBD denotes were
T5921 25043-25052 VBN denotes genotyped
T5920 25033-25037 NNS denotes Mice
T5919 25032-25107 sentence denotes Mice were genotyped at 2 weeks of age by PCR as previously described [21].
T5918 25031-25032 . denotes .
T5917 25030-25031 -RRB- denotes ]
T5916 25029-25030 -RRB- denotes )
T5915 25028-25029 SYM denotes -
T5914 25027-25028 HYPH denotes /
T5913 25026-25027 SYM denotes -
T5912 25025-25026 -LRB- denotes (
T5911 25021-25025 NN denotes Cftr
T5910 25020-25021 -LRB- denotes [
T5909 25015-25019 JJ denotes null
T5908 25004-25014 JJ denotes homozygous
T5907 24999-25003 NN denotes Cftr
T5906 24996-24998 CC denotes or
T5905 24994-24995 -RRB- denotes ]
T5904 24993-24994 -RRB- denotes )
T5903 24992-24993 SYM denotes +
T5902 24991-24992 HYPH denotes /
T5901 24990-24991 SYM denotes +
T5900 24989-24990 -LRB- denotes (
T5899 24985-24989 NN denotes Cftr
T5898 24984-24985 -LRB- denotes [
T5897 24974-24978 JJ denotes wild
T5896 24963-24973 JJ denotes homozygous
T5895 24958-24962 NN denotes Cftr
T5894 24979-24983 NN denotes type
T5893 24951-24957 CC denotes either
T5892 24947-24950 CC denotes and
T5891 24931-24938 NN denotes gastrin
T5890 24939-24946 NNS denotes alleles
T5889 24926-24930 CC denotes both
T5888 24922-24925 IN denotes for
T5887 24917-24921 NN denotes type
T5886 24912-24916 JJ denotes wild
T5885 24907-24911 NNS denotes mice
T5884 24900-24906 VB denotes obtain
T5883 24897-24899 TO denotes to
T5882 24887-24891 VBD denotes were
T5881 24892-24896 VBN denotes bred
T5880 24882-24886 NNS denotes mice
T5879 24876-24881 DT denotes These
T5878 24875-25032 sentence denotes These mice were bred to obtain mice wild type for both gastrin alleles and either Cftr homozygous wild type [Cftr(+/+)] or Cftr homozygous null [Cftr(-/-)].
T5877 24874-24875 . denotes .
T5876 24873-24874 -RRB- denotes )
T5875 24868-24873 RB denotes below
T5874 24864-24867 VB denotes see
T5873 24863-24864 -LRB- denotes (
T5872 24859-24862 CD denotes 129
T5871 24857-24858 NN denotes %
T5870 24856-24857 CD denotes 5
T5869 24852-24855 CC denotes and
T5868 24849-24851 NN denotes B6
T5867 24847-24848 NN denotes %
T5866 24845-24847 CD denotes 95
T5865 24839-24844 RB denotes about
T5864 24829-24833 NNS denotes mice
T5863 24825-24828 DT denotes the
T5862 24834-24838 VBD denotes were
T5861 24820-24824 IN denotes that
T5860 24807-24812 NN denotes point
T5859 24802-24806 DT denotes this
T5858 24799-24801 IN denotes at
T5857 24813-24819 VBD denotes showed
T5856 24787-24793 NN denotes genome
T5855 24794-24798 NN denotes scan
T5854 24785-24786 DT denotes A
T5853 24784-24875 sentence denotes A genome scan at this point showed that the mice were about 95% B6 and 5% 129 (see below).
T5852 24783-24784 . denotes .
T5851 24770-24772 NN denotes B6
T5850 24773-24783 NN denotes background
T5849 24766-24769 DT denotes the
T5848 24763-24765 IN denotes on
T5847 24754-24762 JJ denotes congenic
T5846 24747-24748 -RRB- denotes )
T5845 24746-24747 SYM denotes -
T5844 24745-24746 HYPH denotes /
T5843 24744-24745 SYM denotes +
T5842 24743-24744 -LRB- denotes (
T5841 24749-24753 NNS denotes mice
T5840 24739-24743 NN denotes Cftr
T5839 24734-24738 IN denotes with
T5838 24722-24733 NNS denotes generations
T5837 24718-24721 CD denotes six
T6260 26365-26374 VBN denotes extracted
T6259 26357-26360 NN denotes RNA
T6258 26351-26356 JJ denotes Total
T6257 26350-26436 sentence denotes Total RNA was extracted from the entire small intestine as previously described [21].
T6256 26340-26350 NN denotes expression
T5836 24714-24717 IN denotes for
T5835 24701-24705 RB denotes then
T5834 24696-24700 VBD denotes were
T5833 24706-24713 VBN denotes crossed
T5832 24689-24690 -RRB- denotes )
T5831 24688-24689 SYM denotes -
T5830 24687-24688 HYPH denotes /
T5829 24686-24687 SYM denotes +
T5828 24685-24686 -LRB- denotes (
T5827 24678-24685 NN denotes gastrin
T5826 24691-24695 NNS denotes mice
T5825 24674-24677 DT denotes The
T5824 24673-24784 sentence denotes The gastrin(+/-) mice were then crossed for six generations with Cftr(+/-) mice congenic on the B6 background.
T5823 24672-24673 . denotes .
T5822 24659-24661 NN denotes B6
T5821 24662-24672 NN denotes background
T5820 24655-24658 DT denotes the
T5819 24650-24654 IN denotes onto
T5818 24638-24649 NNS denotes generations
T5817 24632-24637 CD denotes eight
T5816 24628-24631 IN denotes for
T5815 24618-24622 VBD denotes were
T5814 24616-24617 -RRB- denotes ]
T5813 24614-24616 CD denotes 51
T5812 24613-24614 -LRB- denotes [
T5811 24598-24601 CD denotes 129
T5810 24597-24598 HYPH denotes /
T5809 24595-24597 NN denotes B6
T5808 24589-24594 JJ denotes mixed
T5807 24602-24612 NN denotes background
T5806 24587-24588 DT denotes a
T5805 24584-24586 IN denotes on
T5804 24571-24578 NN denotes gastrin
T5803 24579-24583 NN denotes gene
T5802 24567-24570 DT denotes the
T5801 24564-24566 IN denotes of
T5800 24546-24554 VBN denotes targeted
T5799 24555-24563 NN denotes mutation
T5798 24544-24545 DT denotes a
T5797 24535-24543 VBG denotes carrying
T5796 24623-24627 VBN denotes bred
T5795 24530-24534 NNS denotes Mice
T5794 24529-24673 sentence denotes Mice carrying a targeted mutation of the gastrin gene on a mixed B6/129 background [51] were bred for eight generations onto the B6 background.
T5793 24528-24529 . denotes .
T5792 24521-24528 VBZ denotes follows
T5791 24518-24520 IN denotes as
T5790 24516-24517 -RRB- denotes ]
T5789 24514-24516 CD denotes 20
T5788 24513-24514 -LRB- denotes [
T5787 24497-24506 VBN denotes published
T5786 24488-24496 RB denotes recently
T5785 24507-24512 NN denotes study
T5784 24486-24487 DT denotes a
T5783 24483-24485 IN denotes of
T5782 24478-24482 NN denotes part
T5781 24475-24477 IN denotes as
T5780 24447-24452 JJ denotes mixed
T5779 24453-24463 NN denotes background
T5778 24443-24446 DT denotes the
T5777 24440-24442 IN denotes on
T5776 24464-24474 VBD denotes originated
T5775 24435-24439 NNS denotes mice
T5774 24431-24434 DT denotes The
T5773 24430-24529 sentence denotes The mice on the mixed background originated as part of a recently published study [20] as follows.
T5772 24429-24430 . denotes .
T5771 24428-24429 -RRB- denotes )
T5770 24425-24428 CD denotes 129
T5769 24424-24425 -LRB- denotes (
T5768 24420-24421 HYPH denotes /
T5767 24417-24420 CD denotes 129
T5766 24421-24423 NN denotes Sv
T5765 24415-24416 NN denotes %
T5764 24414-24415 CD denotes 5
T5763 24410-24413 CC denotes and
T5762 24407-24409 NN denotes B6
T5761 24405-24406 NN denotes %
T5760 24403-24405 CD denotes 95
T5759 24397-24402 RB denotes about
T5758 24394-24396 IN denotes of
T5757 24377-24382 JJ denotes mixed
T5756 24383-24393 NN denotes background
T5755 24375-24376 DT denotes a
T5754 24372-24374 IN denotes on
T5753 24368-24371 VBD denotes was
T5752 24356-24361 JJ denotes other
T5751 24362-24367 NN denotes group
T5750 24352-24355 DT denotes The
T5749 24351-24430 sentence denotes The other group was on a mixed background of about 95% B6 and 5% 129/Sv (129).
T5748 24350-24351 . denotes .
T5747 24349-24350 -RRB- denotes ]
T5746 24347-24349 CD denotes 21
T5745 24346-24347 -LRB- denotes [
T5744 24325-24335 RB denotes previously
T5743 24336-24345 VBN denotes described
T5742 24322-24324 IN denotes as
T5741 24320-24322 , denotes ,
T5740 24308-24309 -RRB- denotes )
T5739 24306-24308 NN denotes B6
T5738 24305-24306 -LRB- denotes (
T5737 24303-24304 CD denotes 6
T5736 24302-24303 HYPH denotes /
T5735 24297-24302 NN denotes C57Bl
T5734 24310-24320 NN denotes background
T5733 24293-24296 DT denotes the
T5732 24290-24292 IN denotes on
T5731 24281-24289 JJ denotes congenic
T5730 24277-24280 VBD denotes was
T5729 24271-24276 NN denotes group
T5728 24267-24270 CD denotes One
T5727 24266-24351 sentence denotes One group was congenic on the C57Bl/6 (B6) background, as previously described [21].
T5726 24265-24266 . denotes .
T5725 24260-24265 NN denotes study
T5724 24255-24259 DT denotes this
T5723 24252-24254 IN denotes in
T5722 24242-24246 VBD denotes were
T5721 24222-24229 JJ denotes genetic
T5720 24212-24221 JJ denotes different
T5719 24230-24241 NNS denotes backgrounds
T5718 24208-24211 CD denotes two
T5584 24089-24091 IN denotes of
T5583 24078-24088 NN denotes expression
T5582 24071-24077 VBP denotes affect
T5581 24066-24070 WDT denotes that
T5580 24052-24065 NNS denotes polymorphisms
T5579 24042-24047 EX denotes there
T5578 24048-24051 VBP denotes are
T5577 24039-24041 IN denotes if
T5576 24027-24038 VBG denotes determining
T5575 24023-24026 CC denotes and
T5574 24015-24022 NNS denotes regions
T5573 24009-24014 DT denotes these
T5572 24004-24008 RP denotes down
T5571 23994-24003 VBG denotes narrowing
T5570 23991-23993 IN denotes on
T5569 23978-23984 MD denotes should
T5568 23985-23990 VB denotes focus
T5567 23973-23977 NN denotes work
T5566 23966-23972 JJ denotes Future
T5565 23965-24157 sentence denotes Future work should focus on narrowing down these regions and determining if there are polymorphisms that affect expression of specific genes that make the CF intestinal phenotype less severe.
T5564 23964-23965 . denotes .
T5563 23952-23954 NN denotes CF
T5562 23955-23964 NNS denotes modifiers
T5561 23942-23951 JJ denotes potential
T5560 23939-23941 IN denotes as
T5559 23930-23938 NN denotes interest
T5558 23922-23929 JJ denotes special
T5557 23919-23921 IN denotes of
T5556 23906-23914 NN denotes behavior
T5555 23902-23905 CC denotes and
T5554 23875-23885 NN denotes neutrophil
T5553 23871-23874 CC denotes and
T5552 23886-23901 NN denotes differentiation
T5551 23866-23870 NN denotes cell
T5550 23861-23865 NN denotes mast
T5549 23858-23860 IN denotes in
T5548 23845-23848 VBP denotes are
T5547 23849-23857 VBN denotes involved
T5546 23839-23844 WDT denotes which
T5545 23820-23830 VBN denotes identified
T5544 23831-23838 NNS denotes regions
T5543 23816-23819 DT denotes the
T5542 23813-23815 IN denotes in
T5541 23807-23812 NNS denotes genes
T5540 23803-23806 DT denotes the
T5539 23801-23803 , denotes ,
T5538 23792-23801 NN denotes secretion
T5537 23786-23791 NN denotes mucus
T5536 23783-23785 IN denotes on
T5535 23777-23782 NNS denotes cells
T5534 23770-23776 JJ denotes immune
T5533 23767-23769 IN denotes of
T5532 23750-23758 JJ denotes possible
T5531 23759-23766 NNS denotes effects
T5530 23746-23749 DT denotes the
T5529 23742-23745 CC denotes and
T5528 23740-23742 , denotes ,
T5527 23725-23730 JJ denotes small
T5526 23722-23724 NN denotes CF
T5525 23731-23740 NN denotes intestine
T5524 23718-23721 DT denotes the
T5523 23715-23717 IN denotes of
T5522 23702-23714 NN denotes inflammation
T5521 23698-23701 DT denotes the
T5520 23695-23697 IN denotes of
T5519 23915-23918 VBP denotes are
T5518 23687-23694 IN denotes Because
T5517 23686-23965 sentence denotes Because of the inflammation of the CF small intestine, and the possible effects of immune cells on mucus secretion, the genes in the identified regions which are involved in mast cell and neutrophil differentiation and behavior are of special interest as potential CF modifiers.
T5516 23685-23686 . denotes .
T5515 23669-23675 JJR denotes milder
T5514 23676-23685 NN denotes phenotype
T5513 23665-23668 DT denotes the
T5512 23660-23664 IN denotes with
T5511 23637-23648 RB denotes potentially
T5510 23633-23636 VBP denotes are
T5509 23649-23659 VBN denotes associated
T5508 23628-23632 WDT denotes that
T5507 23624-23627 VBP denotes are
T5506 23621-23623 CD denotes 10
T5505 23617-23620 CC denotes and
T5504 23615-23617 , denotes ,
T5503 23614-23615 CD denotes 9
T5502 23612-23614 , denotes ,
T5501 23611-23612 CD denotes 1
T5500 23607-23611 NN denotes chr.
T5499 23604-23606 IN denotes on
T5498 23596-23603 NNS denotes regions
T5497 23585-23595 VBD denotes identified
T5496 23564-23575 JJ denotes preliminary
T5495 23576-23584 NN denotes analysis
T5494 23562-23563 DT denotes A
T5493 23561-23686 sentence denotes A preliminary analysis identified regions on chr.1, 9, and 10 are that are potentially associated with the milder phenotype.
T5492 23560-23561 . denotes .
T5491 23553-23560 NNS denotes alleles
T5490 23549-23550 HYPH denotes /
T5489 23550-23552 NN denotes Sv
T5488 23546-23549 CD denotes 129
T6039 25617-25618 . denotes .
T6038 25614-25617 NN denotes age
T6037 25611-25613 IN denotes of
T6036 25605-25610 NNS denotes weeks
T6035 25601-25602 SYM denotes –
T6034 25602-25604 CD denotes 16
T6033 25600-25601 CD denotes 6
T6032 25597-25599 IN denotes at
T6031 25587-25591 VBD denotes were
T6030 25592-25596 VBN denotes used
T6029 25575-25581 JJ denotes female
T6028 25571-25574 CC denotes and
T6027 25582-25586 NNS denotes mice
T6026 25566-25570 JJ denotes Male
T6025 25565-25618 sentence denotes Male and female mice were used at 6–16 weeks of age.
T6024 25564-25565 . denotes .
T6023 25551-25560 VBG denotes following
T6022 25561-25564 NN denotes day
T6021 25547-25550 DT denotes the
T6020 25544-25546 IN denotes as
T6019 25531-25534 VBD denotes was
T6018 25526-25530 NN denotes chow
T6017 25523-25525 IN denotes on
T6016 25535-25543 VBN denotes recorded
T6015 25514-25522 NN denotes survival
T6014 25510-25513 CC denotes and
T6013 25494-25498 VBD denotes were
T6012 25485-25493 NN denotes distress
T6011 25476-25484 JJ denotes apparent
T6010 25471-25475 IN denotes with
T6009 25499-25509 VBN denotes sacrificed
T6008 25466-25470 NNS denotes Mice
T6007 25465-25565 sentence denotes Mice with apparent distress were sacrificed and survival on chow was recorded as the following day.
T6006 25464-25465 . denotes .
T6005 25452-25455 VBD denotes was
T6004 25456-25464 VBN denotes recorded
T6003 25443-25451 NN denotes survival
T6002 25439-25442 CC denotes and
T6001 25437-25439 , denotes ,
T6000 25429-25437 NNP denotes Peptamen
T5999 25426-25428 IN denotes of
T5998 25418-25425 RB denotes instead
T5997 25407-25412 NN denotes mouse
T5996 25413-25417 NN denotes chow
T5995 25401-25406 JJ denotes solid
T5994 25396-25400 IN denotes onto
T5993 25379-25383 VBD denotes were
T5992 25374-25378 NNS denotes mice
T5991 25370-25373 JJ denotes old
T5990 25365-25369 NN denotes week
T5989 25363-25364 CD denotes 8
T5988 25361-25363 , denotes ,
T5987 25350-25361 NNS denotes experiments
T5986 25345-25349 DT denotes some
T5985 25384-25395 VBN denotes transferred
T5984 25342-25344 IN denotes In
T5983 25341-25465 sentence denotes In some experiments, 8 week old mice were transferred onto solid mouse chow instead of Peptamen, and survival was recorded.
T5982 25340-25341 . denotes .
T5981 25331-25335 JJ denotes same
T5980 25336-25340 NN denotes diet
T5979 25327-25330 DT denotes the
T5978 25324-25326 IN denotes on
T5977 25308-25312 VBD denotes were
T5976 25313-25323 VBN denotes maintained
T5975 25296-25307 NNS denotes littermates
T5974 25291-25295 NN denotes type
T5973 25286-25290 JJ denotes Wild
T5972 25285-25341 sentence denotes Wild type littermates were maintained on the same diet.
T5971 25284-25285 . denotes .
T5970 25283-25284 -RRB- denotes ]
T5969 25281-25283 CD denotes 52
T5968 25280-25281 -LRB- denotes [
T5967 25275-25279 NNS denotes mice
T5966 25272-25274 NN denotes CF
T5965 25269-25271 IN denotes in
T5964 25262-25268 VBZ denotes occurs
T5963 25257-25261 WDT denotes that
T5962 25245-25256 NN denotes obstruction
T5961 25234-25244 JJ denotes intestinal
T5960 25226-25233 VB denotes prevent
T5959 25223-25225 TO denotes to
T5958 25221-25222 -RRB- denotes )
T5957 25219-25221 NNP denotes IL
T5956 25217-25219 , denotes ,
T5955 25201-25207 NNP denotes Nestle
T5954 25199-25200 : denotes ;
T5953 25191-25199 NNP denotes Peptamen
T5952 25208-25217 NNP denotes Deerfield
T5951 25190-25191 -LRB- denotes (
T5950 25178-25184 NN denotes liquid
T5949 25168-25177 JJ denotes elemental
T5948 25159-25167 JJ denotes complete
T5947 25185-25189 NN denotes diet
T5946 25157-25158 DT denotes a
T5945 25154-25156 IN denotes on
T5944 25138-25142 VBD denotes were
T5943 25133-25137 NNS denotes mice
T5942 25131-25133 , denotes ,
T5941 25143-25153 VBN denotes maintained
T5940 25115-25124 RB denotes otherwise
T5939 25125-25131 VBN denotes stated
T5938 25108-25114 IN denotes Unless
T5937 25107-25285 sentence denotes Unless otherwise stated, mice were maintained on a complete elemental liquid diet (Peptamen; Nestle Deerfield, IL) to prevent intestinal obstruction that occurs in CF mice [52].
T5936 25106-25107 . denotes .
T5935 25105-25106 -RRB- denotes ]
T5934 25103-25105 CD denotes 21
T5487 23543-23545 IN denotes of
T5486 23524-23529 JJ denotes small
T5485 23530-23542 NN denotes contribution
T5484 23522-23523 DT denotes a
T5483 23517-23521 IN denotes with
T5482 23512-23516 NNS denotes mice
T5481 23509-23511 IN denotes in
T5480 23502-23508 JJ denotes severe
T5479 23497-23501 RBR denotes less
T5478 23492-23496 RB denotes much
T5477 23466-23478 JJ denotes inflammatory
T5476 23463-23465 NN denotes CF
T5475 23479-23488 NN denotes phenotype
T5474 23459-23462 DT denotes the
T5473 23489-23491 VBZ denotes is
T5472 23454-23458 IN denotes that
T5471 23441-23453 VBD denotes demonstrated
T5470 23436-23440 NN denotes work
T5469 23431-23435 DT denotes This
T5420 23408-23417 NN denotes secretion
T5419 23402-23407 NN denotes mucus
T5418 23390-23401 VBG denotes stimulating
T5417 23387-23389 IN denotes in
T5416 23372-23381 JJ denotes important
T5415 23382-23386 NN denotes role
T5414 23369-23371 DT denotes an
T5413 23362-23363 -RRB- denotes )
T5412 23346-23348 , denotes ,
T5411 23337-23346 NNS denotes proteases
T5410 23335-23337 , denotes ,
T5409 23348-23362 NNS denotes prostaglandins
T5408 23326-23335 NN denotes histamine
T5407 23325-23326 -LRB- denotes (
T5406 23313-23324 NNS denotes neutrophils
T5405 23309-23312 CC denotes and
T5404 23303-23308 NNS denotes cells
T5403 23298-23302 NN denotes mast
T5402 23295-23297 IN denotes by
T5401 23286-23294 VBN denotes released
T5400 23276-23285 NNS denotes molecules
T5399 23267-23275 NN denotes effector
T5398 23364-23368 VBP denotes have
T5397 23262-23266 IN denotes that
T5396 23255-23261 JJ denotes likely
T5395 23252-23254 VBZ denotes is
T5394 23249-23251 PRP denotes it
T5393 23245-23248 CC denotes and
T5392 23243-23245 , denotes ,
T5391 23242-23243 -RRB- denotes ]
T5390 23240-23242 CD denotes 12
T5389 23239-23240 -LRB- denotes [
T5388 23236-23238 NN denotes CF
T5387 23233-23235 IN denotes in
T5386 23227-23232 NN denotes mucus
T5385 23224-23226 IN denotes of
T5384 23209-23223 NN denotes hypersecretion
T5383 23205-23208 IN denotes for
T5382 23196-23204 NN denotes evidence
T5381 23191-23195 RB denotes also
T5380 23182-23187 EX denotes there
T5379 23180-23182 , denotes ,
T5378 23188-23190 VBZ denotes is
T5377 23173-23180 RB denotes However
T5376 23172-23418 sentence denotes However, there is also evidence for hypersecretion of mucus in CF [12], and it is likely that effector molecules released by mast cells and neutrophils (histamine, proteases, prostaglandins) have an important role in stimulating mucus secretion.
T5375 23171-23172 . denotes .
T5374 23165-23171 NNS denotes organs
T5373 23156-23164 VBN denotes affected
T5372 23153-23155 IN denotes of
T5371 23146-23152 NNS denotes lumina
T5370 23142-23145 DT denotes the
T5369 23139-23141 IN denotes in
T5150 22046-22051 NN denotes chr.1
T5149 22043-22045 IN denotes at
T5148 22041-22042 CD denotes 8
T5147 22034-22040 NN denotes weight
T5146 22029-22033 NN denotes body
T5145 22027-22029 , denotes ,
T5144 22022-22027 NN denotes Bw8q1
T5143 22020-22021 : denotes ;
T5142 22018-22020 NN denotes cM
T5141 22015-22017 CD denotes 88
T5140 22013-22015 , denotes ,
T5139 22008-22013 NN denotes chr.1
T5138 22005-22007 IN denotes at
T5137 22003-22004 CD denotes 9
T5136 21995-22002 NN denotes obesity
T5135 21993-21995 , denotes ,
T5134 21989-21993 NN denotes Obq9
T5133 21987-21988 : denotes ;
T5132 21985-21987 NN denotes cM
T5131 21982-21984 CD denotes 85
T5130 21980-21982 , denotes ,
T5129 21975-21980 NN denotes chr.1
T5128 21972-21974 IN denotes at
T5127 21960-21964 NN denotes body
T5126 21954-21959 NN denotes mouse
T5125 21965-21971 NN denotes weight
T5124 21951-21953 NN denotes CF
T5123 21949-21951 , denotes ,
T5122 21944-21949 NN denotes Cfbw1
T5121 21942-21944 : denotes :
T5120 21936-21942 NN denotes weight
T5119 21931-21935 NN denotes body
T5118 21926-21930 IN denotes with
T5117 21915-21925 VBN denotes associated
T5116 21911-21914 NN denotes QTL
T5115 21908-21910 IN denotes of
T5114 21901-21907 NN denotes number
T5113 21899-21900 DT denotes a
T5112 21876-21886 VBN denotes identified
T5111 21887-21894 NNS denotes markers
T5110 21872-21875 DT denotes the
T5109 21867-21871 IN denotes near
T5108 21895-21898 VBP denotes are
T5107 21862-21866 RB denotes Also
T5106 21861-22243 sentence denotes Also near the identified markers are a number of QTL associated with body weight: Cfbw1, CF mouse body weight at chr.1, 85 cM; Obq9, obesity 9 at chr.1, 88 cM; Bw8q1, body weight 8 at chr.1, 100 cM; Lbm6, lean body mass 6 at chr.9, 7.7 cM; Bwtq4, body weight 4 at chr.9, 8 cM; Bgeq8, body growth early 8 at chr.10, 57 cM; and Pbwg5, postnatal body weight growth 5 at chr.10, 68 cM.
T5105 21860-21861 . denotes .
T5104 21859-21860 -RRB- denotes ]
T5103 21857-21859 CD denotes 50
T5102 21856-21857 -LRB- denotes [
T5101 21837-21846 NN denotes signaling
T5100 21847-21855 NNS denotes pathways
T5099 21823-21836 JJ denotes intracellular
T5098 21820-21822 IN denotes of
T5097 21809-21819 NNS denotes components
T5096 21799-21808 JJ denotes important
T5095 21795-21798 VBP denotes are
T5094 21789-21794 WDT denotes which
T5093 21787-21788 -RRB- denotes )
T5092 21785-21787 NN denotes cM
T5091 21782-21784 CD denotes 70
T5090 21780-21782 , denotes ,
T5089 21774-21780 NN denotes chr.10
T5088 21773-21774 -LRB- denotes (
T5087 21765-21766 CD denotes 6
T5086 21761-21764 CC denotes and
T5085 21755-21760 NN denotes Stat2
T5084 21767-21772 NNS denotes genes
T5083 21751-21754 DT denotes the
T5082 21747-21750 CC denotes and
T5081 21745-21746 : denotes ;
T5080 21744-21745 -RRB- denotes ]
T5079 21742-21744 CD denotes 49
T5078 21741-21742 -LRB- denotes [
T5077 21722-21733 NN denotes interleukin
T5076 21719-21721 CD denotes 10
T5075 21718-21719 HYPH denotes -
T5074 21716-21718 NN denotes IL
T5073 21698-21715 JJ denotes anti-inflammatory
T5072 21734-21740 NN denotes family
T5071 21694-21697 DT denotes the
T5070 21691-21693 IN denotes of
T5069 21684-21690 NN denotes member
T5068 21682-21683 DT denotes a
T5067 21680-21682 , denotes ,
T5066 21679-21680 -RRB- denotes )
T5065 21677-21679 NN denotes cM
T5064 21674-21676 CD denotes 67
T5063 21672-21674 , denotes ,
T5062 21666-21672 NN denotes chr.10
T5061 21665-21666 -LRB- denotes (
T5060 21660-21664 NN denotes Il22
T5059 21658-21659 : denotes ;
T5058 21657-21658 -RRB- denotes ]
T5057 21655-21657 CD denotes 48
T5056 21654-21655 -LRB- denotes [
T5055 21643-21653 NNS denotes conditions
T5054 21637-21642 JJ denotes other
T5717 24205-24207 IN denotes on
T5716 24247-24251 VBN denotes used
T5715 24195-24199 JJ denotes null
T5714 24190-24194 NN denotes Cftr
T5713 24186-24189 CC denotes and
T5712 24200-24204 NNS denotes mice
T5711 24181-24185 NN denotes type
T5710 24176-24180 JJ denotes Wild
T5709 24175-24266 sentence denotes Wild type and Cftr null mice on two different genetic backgrounds were used in this study.
T5708 24168-24175 NNS denotes Animals
T5595 24156-24157 . denotes .
T5594 24145-24149 RBR denotes less
T5593 24150-24156 JJ denotes severe
T5592 24124-24134 JJ denotes intestinal
T5591 24121-24123 NN denotes CF
T5590 24135-24144 NN denotes phenotype
T5589 24117-24120 DT denotes the
T5588 24112-24116 VBP denotes make
T5587 24107-24111 WDT denotes that
T5586 24101-24106 NNS denotes genes
T5585 24092-24100 JJ denotes specific
T5053 21629-21633 RB denotes well
T5052 21634-21636 IN denotes as
T5051 21626-21628 RB denotes as
T5050 21623-21625 NN denotes CF
T5049 21620-21622 IN denotes in
T5048 21600-21612 JJ denotes inflammatory
T5047 21590-21599 JJ denotes important
T5046 21613-21619 NN denotes signal
T5045 21587-21589 DT denotes an
T5044 21584-21586 VBZ denotes is
T5043 21578-21583 WDT denotes which
T5042 21576-21577 -RRB- denotes )
T5041 21574-21576 NN denotes cM
T5040 21571-21573 CD denotes 67
T5039 21569-21571 , denotes ,
T5038 21563-21569 NN denotes chr.10
T5037 21562-21563 -LRB- denotes (
T5036 21557-21561 NN denotes Ifng
T5035 21555-21556 : denotes ;
T5034 21554-21555 -RRB- denotes ]
T5033 21552-21554 CD denotes 47
T5032 21551-21552 -LRB- denotes [
T5031 21542-21550 NNS denotes bacteria
T5030 21539-21541 IN denotes of
T5029 21533-21538 NNS denotes walls
T5028 21528-21532 NN denotes cell
T5027 21520-21527 VBZ denotes digests
T5026 21515-21519 WDT denotes that
T5025 21502-21506 NN denotes cell
T5024 21495-21501 NN denotes Paneth
T5023 21507-21514 NN denotes product
T5022 21493-21494 DT denotes a
T5021 21490-21492 VBZ denotes is
T5020 21484-21489 WDT denotes which
T5019 21482-21483 -RRB- denotes )
T5018 21480-21482 NN denotes cM
T5017 21477-21479 CD denotes 66
T5016 21475-21477 , denotes ,
T5015 21469-21475 NN denotes chr.10
T5014 21468-21469 -LRB- denotes (
T5013 21463-21467 NN denotes Lyzs
T5012 21461-21462 : denotes ;
T5011 21460-21461 -RRB- denotes ]
T5010 21458-21460 CD denotes 46
T5009 21457-21458 -LRB- denotes [
T5008 21441-21442 HYPH denotes -
T5006 21433-21441 NN denotes antibody
T5005 21430-21432 IN denotes in
T5004 21418-21420 VBZ denotes is
T5003 21421-21429 VBN denotes involved
T5002 21412-21417 WDT denotes which
T5001 21410-21411 -RRB- denotes )
T5000 21408-21410 NN denotes cM
T4999 21405-21407 CD denotes 65
T4998 21403-21405 , denotes ,
T4997 21397-21403 NN denotes chr.10
T4996 21396-21397 -LRB- denotes (
T4995 21392-21395 NN denotes Im5
T4994 21390-21391 : denotes ;
T4993 21389-21390 -RRB- denotes ]
T4992 21387-21389 CD denotes 45
T4991 21386-21387 -LRB- denotes [
T4990 21370-21385 NN denotes differentiation
T4989 21365-21369 NN denotes cell
T4988 21360-21364 NN denotes mast
T4987 21356-21359 IN denotes for
T4986 21348-21355 JJ denotes crucial
T4985 21345-21347 VBZ denotes is
T4984 21341-21344 CC denotes and
T4983 21339-21341 , denotes ,
T4982 21333-21339 NN denotes factor
T4981 21328-21332 NN denotes cell
T4980 21323-21327 NN denotes stem
T4979 21320-21322 IN denotes as
T4978 21309-21313 RB denotes also
T4977 21306-21308 VBZ denotes is
T4976 21314-21319 VBN denotes known
T4975 21300-21305 WDT denotes which
T4974 21298-21299 -RRB- denotes )
T4973 21296-21298 NN denotes cM
T4972 21293-21295 CD denotes 57
T4971 21291-21293 , denotes ,
T4970 21285-21291 NN denotes chr.10
T4969 21284-21285 -LRB- denotes (
T4968 21279-21283 NN denotes Kitl
T4967 21277-21278 : denotes ;
T4966 21276-21277 -RRB- denotes ]
T4965 21274-21276 CD denotes 44
T4964 21273-21274 -LRB- denotes [
T4963 21265-21272 NNS denotes tissues
T4962 21256-21264 VBN denotes inflamed
T4961 21251-21255 IN denotes into
T4960 21238-21250 NN denotes infiltration
T4959 21227-21237 NN denotes lymphocyte
T4958 21224-21226 IN denotes in
T4957 21212-21214 VBZ denotes is
T4956 21215-21223 VBN denotes involved
T4955 21206-21211 WDT denotes which
T4954 21204-21205 -RRB- denotes )
T4953 21202-21204 NN denotes cM
T4952 21200-21201 CD denotes 7
T4951 21198-21200 , denotes ,
T4950 21193-21198 NN denotes chr.9
T4949 21192-21193 -LRB- denotes (
T4948 21186-21191 NN denotes Icam1
T4947 21184-21185 : denotes ;
T4946 21183-21184 -RRB- denotes ]
T4945 21181-21183 CD denotes 43
T4944 21180-21181 -LRB- denotes [
T4943 21178-21179 -RRB- denotes )
T4942 21168-21169 HYPH denotes -
T4941 21169-21178 NNS denotes defensins
T4940 21167-21168 NN denotes α
T4939 21166-21167 -LRB- denotes (
T4938 21156-21165 NNS denotes cryptdins
T4937 21147-21148 HYPH denotes -
T4936 21148-21155 VBN denotes derived
T4935 21143-21147 NN denotes cell
T4914 21059-21061 NN denotes cM
T4913 21057-21058 CD denotes 1
T4912 21055-21057 , denotes ,
T4911 21050-21055 NN denotes chr.9
T4910 21049-21050 -LRB- denotes (
T4909 21044-21048 NN denotes Mmp3
T4908 21042-21043 : denotes ;
T4907 21041-21042 -RRB- denotes )
T4906 21039-21041 NN denotes cM
T4905 21036-21038 CD denotes 98
T4904 21034-21036 , denotes ,
T4903 21029-21034 NN denotes chr.1
T4902 21028-21029 -LRB- denotes (
T4901 21023-21027 NN denotes Tlr5
T4900 21004-21013 NN denotes flagellin
T4899 21014-21022 NN denotes receptor
T4898 21000-21003 DT denotes the
T4897 20998-20999 : denotes ;
T4896 20997-20998 -RRB- denotes )
T4895 20995-20997 NN denotes cM
T4894 20990-20994 CD denotes 94.2
T4893 20988-20990 , denotes ,
T4892 20983-20988 NN denotes chr.1
T4891 20980-20982 IN denotes at
T4890 20973-20979 NN denotes Fcer1a
T4889 20971-20972 : denotes ;
T4888 20969-20971 NN denotes cM
T4887 20964-20968 CD denotes 93.3
T4886 20962-20964 , denotes ,
T4885 20957-20962 NN denotes chr.1
T4884 20954-20956 IN denotes at
T4883 20947-20953 NN denotes Fcer1g
T4882 20945-20946 : denotes ;
T4881 20943-20945 NN denotes cM
T4880 20938-20942 CD denotes 92.3
T4879 20936-20938 , denotes ,
T4878 20931-20936 NN denotes chr.1
T4877 20928-20930 IN denotes at
T4876 20922-20927 NN denotes Fcgr3
T4875 20918-20921 CC denotes and
T4874 20916-20918 , denotes ,
T4873 20910-20916 NN denotes Fcgr2b
T4872 20908-20910 , denotes ,
T4871 20903-20908 NN denotes Fcrl3
T4870 20902-20903 -LRB- denotes (
T4869 20884-20886 NN denotes Fc
T4868 20887-20895 NN denotes receptor
T4867 20869-20883 NN denotes immunoglobulin
T4866 20896-20901 NNS denotes genes
T4865 20861-20868 JJ denotes several
T4864 20859-20860 : denotes ;
T4863 20858-20859 -RRB- denotes ]
T4862 20856-20858 CD denotes 41
T4861 20855-20856 -LRB- denotes [
T4860 20843-20854 NNS denotes lymphocytes
T4859 20834-20842 VBZ denotes recruits
T4858 20830-20833 CC denotes and
T4857 20824-20829 NNS denotes cells
T4856 20819-20823 NN denotes mast
T4855 20816-20818 IN denotes by
T4854 20803-20805 VBZ denotes is
T4853 20806-20815 VBN denotes expressed
T4852 20797-20802 WDT denotes which
T4851 20795-20796 -RRB- denotes )
T4850 20793-20795 NN denotes cM
T4849 20790-20792 CD denotes 87
T4848 20788-20790 , denotes ,
T4847 20783-20788 NN denotes chr.1
T4846 20782-20783 -LRB- denotes (
T4845 20777-20781 NN denotes Xcl1
T4844 20762-20771 NN denotes chemokine
T4843 20772-20776 NN denotes gene
T4842 20758-20761 DT denotes the
T4841 20756-20757 : denotes ;
T4840 20755-20756 -RRB- denotes ]
T4839 20753-20755 CD denotes 40
T4838 20752-20753 -LRB- denotes [
T4837 20750-20751 -RRB- denotes )
T4836 20748-20750 NN denotes cM
T4835 20742-20743 SYM denotes –
T4834 20743-20747 CD denotes 93.3
T4833 20738-20742 CD denotes 89.5
T4832 20736-20738 , denotes ,
T4831 20729-20730 : denotes ;
T4830 20728-20729 CD denotes 9
T4829 20724-20727 CC denotes and
T4828 20722-20724 , denotes ,
T4827 20721-20722 CD denotes 6
T4826 20719-20721 , denotes ,
T4825 20718-20719 CD denotes 5
T4824 20716-20718 , denotes ,
T4823 20715-20716 CD denotes 2
T4822 20713-20715 , denotes ,
T4821 20707-20713 NN denotes slamf1
T4820 20731-20736 NN denotes chr.1
T4819 20706-20707 -LRB- denotes (
T4818 20694-20698 NN denotes Slam
T5340 22994-22996 PRP denotes It
T5339 22993-23059 sentence denotes It is unclear why mucus accumulates to high levels in CF tissues.
T5338 22992-22993 . denotes .
T5337 22980-22982 NN denotes CF
T5336 22983-22992 NN denotes intestine
T5335 22976-22979 DT denotes the
T5334 22973-22975 IN denotes in
T5333 22954-22959 NN denotes mucus
T5332 22960-22972 NN denotes accumulation
T5331 22944-22953 JJ denotes excessive
T5330 22941-22943 IN denotes to
T5329 22929-22933 RB denotes also
T5328 22925-22928 MD denotes may
T5327 22934-22940 VB denotes relate
T5326 22908-22914 JJ denotes immune
T5325 22915-22924 NNS denotes responses
T5324 22900-22907 VBN denotes Altered
T5323 22899-22993 sentence denotes Altered immune responses may also relate to excessive mucus accumulation in the CF intestine.
T5322 22898-22899 . denotes .
T5321 22883-22891 JJ denotes inflamed
T5320 22892-22898 NN denotes tissue
T5319 22879-22882 DT denotes the
T5318 22874-22878 IN denotes into
T5317 22862-22873 NN denotes circulation
T5316 22858-22861 DT denotes the
T5315 22853-22857 IN denotes from
T5314 22841-22852 NNS denotes neutrophils
T5313 22838-22840 IN denotes of
T5312 22824-22837 NN denotes extravasation
T5311 22820-22823 IN denotes for
T5310 22807-22810 VBP denotes are
T5309 22798-22806 NN denotes proteins
T5308 22792-22797 DT denotes these
T5307 22811-22819 VBN denotes required
T5306 22789-22791 IN denotes as
T5305 22787-22789 , denotes ,
T5304 22779-22787 NN denotes interest
T5303 22776-22778 IN denotes of
T5302 22766-22771 NN denotes Icam1
T5301 22762-22765 CC denotes and
T5300 22752-22761 NNS denotes selectins
T5299 22748-22751 DT denotes the
T5298 22736-22747 NNS denotes neutrophils
T5297 22732-22735 IN denotes for
T5296 22730-22732 , denotes ,
T5295 22772-22775 VBP denotes are
T5294 22721-22730 RB denotes Similarly
T5293 22720-22899 sentence denotes Similarly, for neutrophils the selectins and Icam1 are of interest, as these proteins are required for extravasation of neutrophils from the circulation into the inflamed tissue.
T5292 22719-22720 . denotes .
T5291 22714-22719 NN denotes Mcpt2
T5290 22711-22713 IN denotes of
T5289 22700-22710 NN denotes expression
T5288 22695-22699 JJR denotes less
T5287 22692-22694 IN denotes by
T5286 22683-22691 VBN denotes revealed
T5285 22680-22682 IN denotes as
T5284 22666-22668 NN denotes B6
T5283 22669-22679 NN denotes background
T5282 22662-22665 DT denotes the
T5281 22659-22661 IN denotes on
T5280 22654-22658 IN denotes than
T5279 22643-22647 NN denotes mast
T5278 22636-22642 JJ denotes mature
T5277 22648-22653 NNS denotes cells
T5276 22630-22635 JJR denotes fewer
T5275 22625-22629 RB denotes much
T5274 22603-22608 JJ denotes mixed
T5273 22609-22619 NN denotes background
T5272 22599-22602 DT denotes the
T5271 22596-22598 IN denotes on
T5270 22620-22624 VBP denotes have
T5269 22591-22595 NNS denotes mice
T5268 22588-22590 NN denotes CF
T5267 22584-22587 CC denotes and
T5266 22582-22584 , denotes ,
T5265 22577-22582 NNS denotes cells
T5264 22572-22576 NN denotes mast
T5263 22569-22571 IN denotes of
T5262 22553-22568 NN denotes differentiation
T5261 22549-22552 IN denotes for
T5260 22541-22548 JJ denotes crucial
T5259 22538-22540 VBZ denotes is
T5258 22528-22532 NN denotes Kitl
T5257 22533-22537 NN denotes gene
T5256 22524-22527 DT denotes The
T5255 22523-22720 sentence denotes The Kitl gene is crucial for differentiation of mast cells, and CF mice on the mixed background have much fewer mature mast cells than on the B6 background as revealed by less expression of Mcpt2.
T5254 22522-22523 . denotes .
T5253 22514-22522 NN denotes interest
T5252 22506-22513 JJ denotes special
T5251 22503-22505 IN denotes of
T5250 22493-22498 NNS denotes cells
T5249 22487-22492 DT denotes these
T5248 22480-22486 VBP denotes affect
T5247 22475-22479 WDT denotes that
T5246 22469-22474 NNS denotes genes
T5245 22465-22468 DT denotes the
T5244 22463-22465 , denotes ,
T5243 22452-22463 NNS denotes neutrophils
T5242 22448-22451 CC denotes and
T5241 22442-22447 NNS denotes cells
T5240 22437-22441 NN denotes mast
T5239 22434-22436 IN denotes in
T5238 22424-22433 NNS denotes increases
T5237 22419-22423 IN denotes with
T5236 22417-22419 , denotes ,
T5235 22402-22408 JJ denotes immune
T5234 22397-22401 NN denotes type
T5233 22390-22396 JJ denotes innate
T5232 22409-22417 NN denotes response
T5231 22387-22389 DT denotes an
T5230 22384-22386 IN denotes by
T5229 22499-22502 VBP denotes are
T5228 22367-22369 VBZ denotes is
T5227 22346-22356 JJ denotes intestinal
T5226 22340-22345 NN denotes mouse
T5225 22337-22339 NN denotes CF
T5224 22357-22366 NN denotes phenotype
T5223 22333-22336 DT denotes the
T5222 22370-22383 VBN denotes characterized
T5221 22325-22332 IN denotes Because
T5220 22324-22523 sentence denotes Because the CF mouse intestinal phenotype is characterized by an innate type immune response, with increases in mast cells and neutrophils, the genes that affect these cells are of special interest.
T5219 22323-22324 . denotes .
T5218 22318-22323 NN denotes study
T5217 22313-22317 DT denotes this
T5216 22310-22312 IN denotes in
T5215 22299-22309 VBN denotes identified
T5214 22285-22290 CD denotes three
T5213 22291-22298 NNS denotes regions
T5212 22281-22284 DT denotes the
T5211 22278-22280 IN denotes in
T5210 22272-22277 NNS denotes genes
T5209 22263-22271 JJ denotes numerous
T5208 22253-22258 EX denotes there
T5207 22251-22253 , denotes ,
T5206 22259-22262 VBP denotes are
T5205 22244-22251 RB denotes Clearly
T5204 22243-22324 sentence denotes Clearly, there are numerous genes in the three regions identified in this study.
T5203 22242-22243 . denotes .
T5202 22240-22242 NN denotes cM
T5201 22237-22239 CD denotes 68
T5200 22235-22237 , denotes ,
T5199 22229-22235 NN denotes chr.10
T5198 22226-22228 IN denotes at
T5197 22224-22225 CD denotes 5
T5196 22210-22216 NN denotes weight
T5195 22205-22209 NN denotes body
T5194 22217-22223 NN denotes growth
T5193 22195-22204 JJ denotes postnatal
T5192 22193-22195 , denotes ,
T5191 22188-22193 NN denotes Pbwg5
T5190 22184-22187 CC denotes and
T5189 22182-22183 : denotes ;
T5188 22180-22182 NN denotes cM
T5187 22177-22179 CD denotes 57
T5186 22175-22177 , denotes ,
T5185 22169-22175 NN denotes chr.10
T5184 22166-22168 IN denotes at
T5183 22164-22165 CD denotes 8
T5182 22158-22163 RB denotes early
T5181 22151-22157 NN denotes growth
T5180 22146-22150 NN denotes body
T5179 22144-22146 , denotes ,
T5178 22139-22144 NN denotes Bgeq8
T5177 22137-22138 : denotes ;
T5176 22135-22137 NN denotes cM
T5175 22133-22134 CD denotes 8
T5174 22131-22133 , denotes ,
T5173 22126-22131 NN denotes chr.9
T5172 22123-22125 IN denotes at
T5171 22121-22122 CD denotes 4
T5170 22114-22120 NN denotes weight
T5169 22109-22113 NN denotes body
T5168 22107-22109 , denotes ,
T5167 22102-22107 NN denotes Bwtq4
T5166 22100-22101 : denotes ;
T5165 22098-22100 NN denotes cM
T5164 22094-22097 CD denotes 7.7
T5163 22092-22094 , denotes ,
T5162 22087-22092 NN denotes chr.9
T5161 22084-22086 IN denotes at
T5160 22082-22083 CD denotes 6
T5159 22072-22076 NN denotes body
T5158 22077-22081 NN denotes mass
T5157 22067-22071 JJ denotes lean
T5156 22065-22067 , denotes ,
T5155 22061-22065 NN denotes Lbm6
T5154 22059-22060 : denotes ;
T5153 22057-22059 NN denotes cM
T5152 22053-22056 CD denotes 100
T5151 22051-22053 , denotes ,
T4817 20699-20705 NN denotes family
T4816 20690-20693 DT denotes the
T4815 20687-20689 IN denotes of
T4814 20670-20677 NN denotes surface
T4813 20678-20686 NN denotes proteins
T4812 20665-20669 NN denotes cell
T4811 20658-20664 JJ denotes immune
T4810 20655-20657 IN denotes of
T4809 20647-20654 NNS denotes members
T4808 20639-20646 JJ denotes several
T4807 20637-20638 : denotes ;
T4806 20636-20637 -RRB- denotes ]
T4805 20634-20636 CD denotes 39
T4804 20633-20634 -LRB- denotes [
T4803 20625-20632 NNS denotes tissues
T4802 20616-20624 JJ denotes inflamed
T4801 20611-20615 IN denotes into
T4800 20598-20610 NN denotes infiltration
T4799 20593-20597 NN denotes cell
T4798 20586-20592 JJ denotes immune
T4797 20583-20585 IN denotes in
T4796 20570-20573 VBP denotes are
T4795 20574-20582 VBN denotes involved
T4794 20564-20569 WDT denotes which
T4793 20562-20563 -RRB- denotes )
T4792 20560-20562 NN denotes cM
T4791 20555-20559 CD denotes 86.6
T4790 20553-20555 , denotes ,
T4789 20546-20548 , denotes ,
T4788 20542-20546 NN denotes Selp
T4787 20540-20542 , denotes ,
T4786 20536-20540 NN denotes Sell
T4785 20534-20536 , denotes ,
T4784 20530-20534 NN denotes Sele
T4783 20548-20553 NN denotes chr.1
T4782 20529-20530 -LRB- denotes (
T4781 20514-20522 NN denotes selectin
T4780 20523-20528 NNS denotes genes
T4779 20508-20513 CD denotes three
T4778 20506-20507 : denotes ;
T4777 20505-20506 -RRB- denotes ]
T4776 20502-20503 , denotes ,
T4775 20500-20502 CD denotes 37
T4774 20503-20505 CD denotes 38
T4773 20499-20500 -LRB- denotes [
T4772 20488-20498 NN denotes activation
T4771 20483-20487 NN denotes cell
T4770 20481-20482 NN denotes T
T4769 20478-20480 IN denotes in
T4768 20465-20468 VBP denotes are
T4767 20469-20477 VBN denotes involved
T4766 20459-20464 WDT denotes which
T4765 20457-20458 -RRB- denotes )
T4764 20455-20457 NN denotes cM
T4763 20451-20452 SYM denotes –
T4762 20452-20454 CD denotes 85
T4761 20447-20451 CD denotes 84.9
T4760 20445-20447 , denotes ,
T4759 20440-20445 NN denotes chr.1
T4758 20439-20440 -LRB- denotes (
T4757 20437-20438 CD denotes 8
T4756 20433-20436 CC denotes and
T4755 20431-20433 , denotes ,
T4754 20430-20431 CD denotes 6
T4753 20428-20430 , denotes ,
T4752 20414-20421 NNS denotes members
T4751 20402-20413 NN denotes superfamily
T4750 20422-20428 NN denotes Tnfsf4
T4749 20398-20401 NN denotes TNF
T4748 20396-20398 : denotes :
T4747 20386-20396 VBN denotes identified
T4746 20378-20385 NNS denotes markers
T4745 20374-20377 DT denotes the
T4744 20371-20373 IN denotes of
T4743 20363-20370 NNS denotes regions
T4742 20359-20362 DT denotes the
T4741 20356-20358 IN denotes in
T4740 20344-20347 VBP denotes are
T4739 20330-20336 JJ denotes immune
T4738 20337-20343 NN denotes system
T4737 20326-20329 DT denotes the
T4736 20322-20325 CC denotes and
T4735 20309-20321 NN denotes inflammation
T4734 20306-20308 IN denotes in
T4733 20297-20305 VBN denotes involved
T4732 20348-20355 VBN denotes located
T4731 20291-20296 NNS denotes genes
T4730 20283-20290 JJ denotes Several
T4729 20282-21861 sentence denotes Several genes involved in inflammation and the immune system are located in the regions of the markers identified: TNF superfamily members Tnfsf4, 6, and 8 (chr.1, 84.9–85 cM) which are involved in T cell activation [37,38]; three selectin genes (Sele, Sell, Selp, chr.1, 86.6 cM) which are involved in immune cell infiltration into inflamed tissues [39]; several members of immune cell surface proteins of the Slam family (slamf1, 2, 5, 6, and 9; chr.1, 89.5–93.3 cM) [40]; the chemokine gene Xcl1 (chr.1, 87 cM) which is expressed by mast cells and recruits lymphocytes [41]; several immunoglobulin Fc receptor genes (Fcrl3, Fcgr2b, and Fcgr3 at chr.1, 92.3 cM; Fcer1g at chr.1, 93.3 cM; Fcer1a at chr.1, 94.2 cM); the flagellin receptor Tlr5 (chr.1, 98 cM); Mmp3 (chr.9, 1 cM) which recruits CD4+ lymphocytes [42]; Mmp7 (chr.9, 1 cM) which activates Paneth cell-derived cryptdins (α-defensins) [43]; Icam1 (chr.9, 7 cM) which is involved in lymphocyte infiltration into inflamed tissues [44]; Kitl (chr.10, 57 cM) which is also known as stem cell factor, and is crucial for mast cell differentiation [45]; Im5 (chr.10, 65 cM) which is involved in antibody-responsiveness [46]; Lyzs (chr.10, 66 cM) which is a Paneth cell product that digests cell walls of bacteria [47]; Ifng (chr.10, 67 cM) which is an important inflammatory signal in CF as well as other conditions [48]; Il22 (chr.10, 67 cM), a member of the anti-inflammatory IL-10 interleukin family [49]; and the Stat2 and 6 genes (chr.10, 70 cM) which are important components of intracellular signaling pathways [50].
T4728 20281-20282 . denotes .
T4727 20268-20281 JJ denotes controversial
T4726 20252-20264 NN denotes inflammation
T4725 20242-20251 JJ denotes excessive
T4724 20239-20241 IN denotes to
T4723 20227-20238 VBZ denotes predisposes
T4722 20222-20226 WDT denotes that
T4721 20219-20221 NN denotes CF
T4720 20216-20218 IN denotes in
T4719 20200-20208 JJ denotes inherent
T4718 20209-20215 NN denotes defect
T4717 20197-20199 DT denotes an
T4716 20265-20267 VBZ denotes is
T4715 20188-20193 EX denotes there
T4714 20194-20196 VBZ denotes is
T4713 20180-20187 IN denotes whether
T4712 20176-20179 CC denotes and
T4711 20174-20176 , denotes ,
T4710 20172-20174 NN denotes CF
T4709 20169-20171 IN denotes of
T4708 20160-20168 NN denotes hallmark
T4707 20158-20159 DT denotes a
T4706 20155-20157 VBZ denotes is
T4705 20142-20154 NN denotes Inflammation
T4704 20141-20282 sentence denotes Inflammation is a hallmark of CF, and whether there is an inherent defect in CF that predisposes to excessive inflammation is controversial.
T4703 20140-20141 . denotes .
T4702 20113-20119 NNP denotes Genome
T4701 20120-20131 NNP denotes Informatics
T4700 20107-20112 NNP denotes Mouse
T4699 20132-20139 NN denotes website
T4665 20002-20003 -RRB- denotes )
T4664 20000-20002 NN denotes cM
T4663 19995-19999 CD denotes 94.2
T4662 19993-19995 , denotes ,
T4661 19988-19993 NN denotes chr.1
T4660 19987-19988 -LRB- denotes (
T4659 19981-19986 NN denotes Kcnj9
T4658 19979-19981 : denotes :
T4657 19964-19969 NN denotes fluid
T4656 19960-19963 CC denotes and
T4655 19970-19979 NN denotes transport
T4654 19948-19959 NN denotes electrolyte
T4653 19935-19940 MD denotes could
T4652 19923-19934 RB denotes potentially
T4651 19941-19947 VB denotes affect
T4650 19918-19922 WDT denotes that
T4649 19899-19909 VBN denotes identified
T4648 19910-19917 NNS denotes regions
T4647 19895-19898 DT denotes the
T4646 19892-19894 IN denotes in
T4645 19878-19885 NN denotes channel
T4644 19868-19877 NN denotes potassium
T4643 19886-19891 NNS denotes genes
T4642 19860-19867 JJ denotes several
T4641 19856-19859 VBP denotes are
T4640 19850-19855 EX denotes There
T4639 19849-20078 sentence denotes There are several potassium channel genes in the identified regions that potentially could affect electrolyte and fluid transport: Kcnj9 (chr.1, 94.2 cM), Kcnj10 (chr.1, 93.5 cM), Kcnj5 (chr.9, 11 cM), and Kcnc2 (chr.10, 62 cM).
T4638 19848-19849 . denotes .
T4637 19832-19838 JJR denotes milder
T4636 19839-19848 NN denotes phenotype
T4635 19828-19831 DT denotes the
T4634 19823-19827 IN denotes with
T4633 19812-19822 VBN denotes associated
T4632 19794-19799 CD denotes three
T4631 19800-19811 NNS denotes chromosomes
T4630 19790-19793 DT denotes the
T4629 19787-19789 IN denotes of
T4628 19779-19786 NNS denotes regions
T4627 19775-19778 DT denotes the
T4626 19772-19774 IN denotes in
T4625 19755-19762 JJ denotes missing
T4624 19763-19767 NN denotes CFTR
T4623 19751-19754 DT denotes the
T4622 19747-19750 IN denotes for
T4621 19730-19735 MD denotes might
T4620 19736-19746 VB denotes substitute
T4619 19725-19729 WDT denotes that
T4618 19707-19715 NN denotes chloride
T4617 19701-19706 JJ denotes known
T4616 19716-19724 NNS denotes channels
T4615 19697-19700 DT denotes the
T4614 19694-19696 IN denotes of
T4613 19768-19771 VBP denotes are
T4612 19689-19693 NN denotes None
T4611 19688-19849 sentence denotes None of the known chloride channels that might substitute for the missing CFTR are in the regions of the three chromosomes associated with the milder phenotype.
T4610 19687-19688 . denotes .
T4609 19667-19677 JJ denotes intestinal
T4608 19664-19666 NN denotes CF
T4607 19657-19663 JJR denotes milder
T4606 19678-19687 NN denotes phenotype
T4605 19653-19656 DT denotes the
T4604 19650-19652 IN denotes to
T4603 19640-19649 NN denotes relevance
T4602 19630-19639 JJ denotes potential
T4601 19626-19629 IN denotes for
T4600 19623-19625 IN denotes at
T4599 19611-19615 VBD denotes were
T4598 19603-19610 NNS denotes markers
T4597 19599-19602 DT denotes the
T4596 19596-19598 IN denotes of
T4595 19591-19595 NN denotes side
T4594 19584-19590 DT denotes either
T4593 19581-19583 IN denotes on
T4592 19572-19580 NN denotes interval
T4591 19567-19571 DT denotes this
T4590 19564-19566 IN denotes of
T4589 19562-19563 NN denotes %
T4588 19560-19562 CD denotes 75
T4587 19553-19559 IN denotes within
T4586 19547-19552 NNS denotes genes
T4585 19545-19547 , denotes ,
T4584 19543-19545 NN denotes cM
T4583 19540-19542 CD denotes 12
T4582 19534-19539 IN denotes about
T5368 23120-23126 JJ denotes acidic
T5367 23115-23119 RBR denotes more
T5366 23127-23138 NN denotes environment
T5365 23113-23114 DT denotes a
T5364 23109-23112 CC denotes and
T5363 23093-23098 NN denotes fluid
T5362 23099-23108 NN denotes secretion
T5361 23085-23092 VBN denotes reduced
T5360 23082-23084 IN denotes to
T5359 23078-23081 IN denotes due
T5358 23071-23074 MD denotes may
T5357 23068-23070 PRP denotes it
T5356 23063-23067 JJ denotes part
T5355 23075-23077 VB denotes be
T5354 23060-23062 IN denotes In
T5353 23059-23172 sentence denotes In part it may be due to reduced fluid secretion and a more acidic environment in the lumina of affected organs.
T5352 23058-23059 . denotes .
T5351 23051-23058 NNS denotes tissues
T5350 23048-23050 NN denotes CF
T5349 23045-23047 IN denotes in
T5348 23038-23044 NNS denotes levels
T5347 23033-23037 JJ denotes high
T5346 23030-23032 IN denotes to
T5345 23012-23017 NN denotes mucus
T5344 23018-23029 VBZ denotes accumulates
T5343 23008-23011 WRB denotes why
T5342 23000-23007 JJ denotes unclear
T5341 22997-22999 VBZ denotes is
T4934 21136-21142 NN denotes Paneth
T4933 21126-21135 VBZ denotes activates
T4932 21120-21125 WDT denotes which
T4931 21118-21119 -RRB- denotes )
T4930 21116-21118 NN denotes cM
T4929 21114-21115 CD denotes 1
T4928 21112-21114 , denotes ,
T4927 21107-21112 NN denotes chr.9
T4926 21106-21107 -LRB- denotes (
T4925 21101-21105 NN denotes Mmp7
T4924 21099-21100 : denotes ;
T4923 21098-21099 -RRB- denotes ]
T4922 21096-21098 CD denotes 42
T4921 21095-21096 -LRB- denotes [
T4920 21081-21082 SYM denotes +
T4919 21083-21094 NNS denotes lymphocytes
T4918 21078-21081 NN denotes CD4
T4917 21069-21077 VBZ denotes recruits
T4916 21063-21068 WDT denotes which
T4915 21061-21062 -RRB- denotes )
T4549 18680-18681 -LRB- denotes (
T4548 18677-18679 NN denotes cM
T4547 18674-18676 CD denotes 65
T4546 18672-18674 , denotes ,
T4545 18666-18672 NN denotes chr.10
T4544 18662-18665 CC denotes and
T4543 18660-18661 : denotes ;
T4542 18659-18660 -RRB- denotes )
T4541 18648-18651 CD denotes 129
T4540 18652-18659 NNS denotes alleles
T4539 18644-18647 CD denotes two
T4538 18632-18634 CD denotes 11
T4537 18635-18639 NNS denotes mice
T4536 18628-18631 DT denotes all
T4535 18640-18643 VBD denotes had
T4534 18627-18628 -LRB- denotes (
T4533 18624-18626 NN denotes cM
T4532 18622-18623 CD denotes 9
T4531 18620-18622 , denotes ,
T4530 18615-18620 NN denotes chr.9
T4529 18613-18614 : denotes ;
T4528 18612-18613 -RRB- denotes )
T4527 18601-18604 CD denotes 129
T4526 18597-18600 CC denotes and
T4525 18605-18612 NNS denotes alleles
T4524 18594-18596 NN denotes B6
T4523 18589-18593 CC denotes both
T4522 18580-18584 NNS denotes mice
T4521 18574-18576 IN denotes of
T4520 18577-18579 CD denotes 11
T4519 18572-18573 CD denotes 9
T4518 18585-18588 VBD denotes had
T4517 18571-18572 -LRB- denotes (
T4516 18568-18570 NN denotes cM
T4515 18565-18567 CD denotes 92
T4514 18563-18565 , denotes ,
T4513 18558-18563 NN denotes chr.1
T4512 18555-18557 IN denotes at
T4511 18542-18544 NN denotes CF
T4510 18535-18541 NN denotes strain
T4509 18529-18534 JJ denotes mixed
T4508 18545-18549 NNS denotes mice
T4507 18525-18528 DT denotes the
T4506 18522-18524 IN denotes in
T4505 18550-18554 VBD denotes were
T4504 18510-18521 NNS denotes differences
T4503 18506-18509 DT denotes The
T4502 18505-18718 sentence denotes The differences in the mixed strain CF mice were at chr.1, 92 cM (9 of 11 mice had both B6 and 129 alleles); chr.9, 9 cM (all 11 mice had two 129 alleles); and chr.10, 65 cM (10 mice had both B6 and 129 alleles).
T4501 18504-18505 . denotes .
T4500 18503-18504 CD denotes 3
T4499 18497-18502 NN denotes Table
T4498 18494-18496 IN denotes in
T4497 18481-18484 VBP denotes are
T4496 18468-18471 CD denotes two
T4495 18472-18480 NNS denotes analyses
T4494 18464-18467 DT denotes the
T4493 18459-18463 IN denotes from
T4492 18453-18458 VBN denotes found
T4491 18485-18493 VBN denotes combined
T4490 18441-18452 NNS denotes differences
T4489 18437-18440 DT denotes The
T4488 18436-18505 sentence denotes The differences found from the two analyses are combined in Table 3.
T4487 18435-18436 . denotes .
T4486 18426-18428 NN denotes B6
T4485 18429-18435 NN denotes strain
T4484 18422-18425 DT denotes the
T4483 18417-18421 IN denotes from
T4482 18406-18416 NNS denotes variations
T4481 18398-18405 VBG denotes showing
T4480 18378-18389 JJ denotes chromosomal
T4479 18390-18397 NNS denotes regions
T4478 18374-18377 DT denotes the
T4477 18371-18373 IN denotes on
T4476 18365-18370 VB denotes focus
T4475 18362-18364 TO denotes to
T4474 18349-18353 VBD denotes were
T4473 18344-18348 VBN denotes used
T4472 18354-18361 VBN denotes refined
T4471 18336-18343 NNS denotes markers
T4470 18332-18335 DT denotes the
T4469 18328-18331 CC denotes and
T4468 18315-18318 VBD denotes was
T4467 18307-18309 NN denotes CF
T4466 18310-18314 NNS denotes mice
T4465 18305-18306 CD denotes 8
T4464 18302-18304 IN denotes of
T4463 18319-18327 VBN denotes analyzed
T4462 18289-18295 JJ denotes second
T4461 18296-18301 NN denotes group
T4460 18287-18288 DT denotes A
T4459 18286-18436 sentence denotes A second group of 8 CF mice was analyzed and the markers used were refined to focus on the chromosomal regions showing variations from the B6 strain.
T4458 18285-18286 . denotes .
T4457 18282-18285 CD denotes 129
T4456 18280-18281 NN denotes %
T4455 18279-18280 CD denotes 5
T4454 18277-18279 , denotes ,
T4453 18275-18277 NN denotes B6
T4452 18273-18274 NN denotes %
T4451 18271-18273 CD denotes 95
T4450 18268-18270 VB denotes be
T4431 18182-18183 -LRB- denotes [
T4430 18179-18181 NN denotes cM
T4429 18175-18178 CD denotes 3.1
T4428 18173-18175 , denotes ,
T4427 18168-18173 NN denotes chr.6
T4426 18165-18167 IN denotes at
T4425 18162-18164 VBZ denotes is
T4424 18156-18161 WDT denotes which
T4423 18146-18150 NN denotes Cftr
T4422 18137-18145 VBN denotes targeted
T4421 18151-18155 NN denotes gene
T4420 18133-18136 DT denotes the
T4419 18130-18132 IN denotes to
T4418 18126-18129 IN denotes due
T4417 18117-18125 RB denotes probably
T4416 18114-18116 VBZ denotes is
T4415 18108-18113 WDT denotes which
T4414 18105-18107 NN denotes cM
T4413 18103-18104 CD denotes 1
T4412 18101-18103 , denotes ,
T4411 18100-18101 CD denotes 6
T4410 18089-18099 NN denotes chromosome
T4409 18086-18088 IN denotes on
T4408 18074-18077 CD denotes 129
T4407 18070-18073 CC denotes and
T4406 18078-18085 NNS denotes markers
T4405 18067-18069 NN denotes B6
T4404 18062-18066 CC denotes both
T4403 18058-18061 VBD denotes had
T4402 18046-18052 CD denotes twelve
T4401 18053-18057 NNS denotes mice
T4400 18042-18045 DT denotes All
T4399 18041-18187 sentence denotes All twelve mice had both B6 and 129 markers on chromosome 6, 1 cM which is probably due to the targeted Cftr gene which is at chr.6, 3.1 cM [36].
T4398 18040-18041 . denotes .
T4397 18038-18040 NN denotes cM
T4396 18035-18037 CD denotes 40
T4395 18033-18035 , denotes ,
T4394 18028-18033 NN denotes chr.9
T4393 18025-18027 IN denotes at
T4392 18017-18024 NNS denotes strains
T4391 18012-18016 DT denotes both
T4390 18007-18011 IN denotes from
T4389 17999-18006 NNS denotes alleles
T4388 17983-17989 CD denotes twelve
T4387 17990-17994 NNS denotes mice
T4386 17979-17982 DT denotes the
T4385 17976-17978 IN denotes of
T4384 17995-17998 VBD denotes had
T4383 17972-17975 CD denotes One
T4382 17971-18041 sentence denotes One of the twelve mice had alleles from both strains at chr.9, 40 cM.
T4381 17970-17971 . denotes .
T4380 17960-17962 NN denotes B6
T4379 17963-17970 NNS denotes alleles
T4378 17958-17959 NN denotes %
T4377 17954-17958 CD denotes 99.5
T4376 17931-17933 NN denotes B6
T4375 17934-17944 NN denotes background
T4374 17927-17930 DT denotes the
T4373 17924-17926 IN denotes on
T4372 17945-17953 VBD denotes averaged
T4371 17916-17918 NN denotes CF
T4370 17919-17923 NNS denotes mice
T4369 17909-17915 CD denotes Twelve
T4368 17908-17971 sentence denotes Twelve CF mice on the B6 background averaged 99.5% B6 alleles.
T4367 17907-17908 . denotes .
T4366 17905-17907 NN denotes B6
T4365 17896-17904 JJ denotes congenic
T4364 17892-17895 VBP denotes are
T4363 17887-17891 PRP denotes they
T4362 17879-17886 VB denotes confirm
T4361 17876-17878 TO denotes to
T4360 17862-17866 RB denotes also
T4359 17857-17861 VBD denotes were
T4358 17855-17857 , denotes ,
T4357 17839-17844 JJ denotes mixed
T4356 17835-17838 CD denotes 129
T4355 17834-17835 HYPH denotes /
T4354 17832-17834 NN denotes B6
T4353 17845-17855 NN denotes background
T4352 17830-17831 DT denotes a
T4351 17827-17829 IN denotes on
T4350 17816-17826 RB denotes originally
T4349 17811-17815 NNS denotes mice
T4348 17806-17810 IN denotes from
T4347 17793-17797 VBD denotes were
T4346 17798-17805 VBN denotes derived
T4345 17787-17792 WDT denotes which
T4344 17785-17787 , denotes ,
T4343 17772-17774 NN denotes B6
T4342 17775-17785 NN denotes background
T4341 17768-17771 DT denotes the
T4340 17765-17767 IN denotes on
T4339 17756-17764 JJ denotes congenic
T4338 17867-17875 VBN denotes analyzed
T4337 17751-17755 NNS denotes Mice
T4336 17750-17908 sentence denotes Mice congenic on the B6 background, which were derived from mice originally on a B6/129 mixed background, were also analyzed to confirm they are congenic B6.
T4335 17749-17750 . denotes .
T4698 20103-20106 DT denotes the
T4697 20098-20102 IN denotes from
T4696 20094-20097 VBP denotes are
T4695 20083-20087 NN denotes gene
T4694 20088-20093 NNS denotes names
T4693 20079-20082 DT denotes All
T4692 20078-20141 sentence denotes All gene names are from the Mouse Genome Informatics website .
T4691 20077-20078 . denotes .
T4690 20076-20077 -RRB- denotes )
T4689 20074-20076 NN denotes cM
T4688 20071-20073 CD denotes 62
T4687 20069-20071 , denotes ,
T4686 20063-20069 NN denotes chr.10
T4685 20062-20063 -LRB- denotes (
T4684 20056-20061 NN denotes Kcnc2
T4683 20052-20055 CC denotes and
T4682 20050-20052 , denotes ,
T4681 20049-20050 -RRB- denotes )
T4680 20044-20046 CD denotes 11
T4679 20042-20044 , denotes ,
T4678 20037-20042 NN denotes chr.9
T4677 20047-20049 NN denotes cM
T4676 20036-20037 -LRB- denotes (
T4675 20030-20035 NN denotes Kcnj5
T4674 20028-20030 , denotes ,
T4673 20027-20028 -RRB- denotes )
T4672 20025-20027 NN denotes cM
T4671 20020-20024 CD denotes 93.5
T4670 20018-20020 , denotes ,
T4669 20013-20018 NN denotes chr.1
T4668 20012-20013 -LRB- denotes (
T4667 20005-20011 NN denotes Kcnj10
T4666 20003-20005 , denotes ,
T4334 17736-17741 NN denotes mouse
T4333 17732-17735 CD denotes two
T4332 17742-17749 NNS denotes strains
T4331 17726-17731 DT denotes these
T4330 17718-17725 IN denotes between
T4329 17704-17717 NNS denotes polymorphisms
T4328 17701-17703 IN denotes of
T4327 17693-17700 NNS denotes markers
T4326 17689-17692 IN denotes for
T4325 17685-17688 NN denotes PCR
T4324 17682-17684 IN denotes by
T4323 17669-17672 VBD denotes was
T4322 17665-17668 NN denotes DNA
T4321 17660-17664 NN denotes tail
T4320 17658-17660 , denotes ,
T4319 17642-17650 NN denotes modifier
T4318 17651-17658 NNS denotes regions
T4317 17632-17641 JJ denotes potential
T4316 17623-17631 VB denotes identify
T4315 17620-17622 TO denotes to
T4314 17616-17619 CC denotes and
T4313 17614-17616 , denotes ,
T4312 17596-17603 JJ denotes genetic
T4311 17590-17595 JJ denotes mixed
T4310 17604-17614 NN denotes background
T4309 17586-17589 DT denotes the
T4308 17583-17585 IN denotes to
T4307 17571-17574 CD denotes 129
T4306 17567-17570 CC denotes and
T4305 17575-17582 NNS denotes alleles
T4304 17564-17566 NN denotes B6
T4303 17561-17563 IN denotes of
T4302 17547-17560 NNS denotes contributions
T4301 17543-17546 DT denotes the
T4300 17673-17681 VBN denotes analyzed
T4299 17533-17542 VB denotes determine
T4298 17530-17532 TO denotes To
T4297 17529-17750 sentence denotes To determine the contributions of B6 and 129 alleles to the mixed genetic background, and to identify potential modifier regions, tail DNA was analyzed by PCR for markers of polymorphisms between these two mouse strains.
T4296 17516-17524 NN denotes modifier
T4295 17525-17529 NNS denotes loci
T4294 17506-17515 JJ denotes potential
T4293 17503-17505 IN denotes of
T4292 17488-17502 NN denotes Identification
T4449 18265-18267 TO denotes to
T4448 18259-18264 VBN denotes found
T4447 18254-18258 VBD denotes were
T4446 18250-18253 CC denotes and
T4445 18231-18240 RB denotes initially
T4444 18226-18230 VBD denotes were
T4443 18209-18214 JJ denotes mixed
T4442 18215-18225 NN denotes background
T4441 18205-18208 DT denotes the
T4440 18202-18204 IN denotes on
T4439 18241-18249 VBN denotes analyzed
T4438 18194-18196 NN denotes CF
T4437 18197-18201 NNS denotes mice
T4436 18188-18193 CD denotes Three
T4435 18187-18286 sentence denotes Three CF mice on the mixed background were initially analyzed and were found to be 95% B6, 5% 129.
T4434 18186-18187 . denotes .
T4433 18185-18186 -RRB- denotes ]
T4432 18183-18185 CD denotes 36
T3733 16842-16843 . denotes .
T3732 16841-16842 -RRB- denotes )
T3731 16840-16841 CD denotes 4
T3730 16835-16839 NN denotes Fig.
T3729 16834-16835 -LRB- denotes (
T3728 16812-16817 JJ denotes mixed
T3727 16818-16828 NN denotes background
T3726 16808-16811 DT denotes the
T3725 16805-16807 IN denotes on
T3724 16797-16799 NN denotes CF
T3723 16800-16804 NNS denotes mice
T3722 16793-16796 DT denotes the
T3721 16790-16792 IN denotes of
T3720 16788-16789 NN denotes %
T3719 16786-16788 CD denotes 22
T3718 16781-16785 RB denotes only
T3717 16779-16781 , denotes ,
T3716 16771-16779 NN denotes contrast
T3715 16829-16833 VBD denotes died
T3714 16768-16770 IN denotes In
T3713 16767-16843 sentence denotes In contrast, only 22% of the CF mice on the mixed background died (Fig. 4).
T3712 16766-16767 . denotes .
T3711 16755-16759 NN denotes week
T3710 16753-16754 CD denotes 8
T3709 16760-16766 NN denotes period
T3708 16749-16752 DT denotes the
T3707 16744-16748 IN denotes over
T3706 16734-16743 NN denotes mortality
T3705 16732-16733 NN denotes %
T3704 16730-16732 CD denotes 60
T3703 16724-16729 RB denotes about
T3702 16719-16723 IN denotes with
T3701 16717-16719 , denotes ,
T3700 16713-16717 NN denotes chow
T3699 16707-16712 JJ denotes solid
T3698 16704-16706 IN denotes on
T3697 16698-16703 NNS denotes weeks
T3696 16695-16696 SYM denotes –
T3695 16696-16697 CD denotes 3
T3694 16694-16695 CD denotes 2
T3693 16687-16693 IN denotes within
T3692 16668-16670 NN denotes B6
T3691 16671-16681 NN denotes background
T3690 16664-16667 DT denotes the
T3689 16661-16663 IN denotes on
T3688 16656-16660 NNS denotes mice
T3687 16653-16655 NN denotes CF
T3686 16650-16652 IN denotes of
T3685 16682-16686 VBD denotes died
T3684 16641-16649 NN denotes majority
T3683 16637-16640 DT denotes The
T3682 16636-16767 sentence denotes The majority of CF mice on the B6 background died within 2–3 weeks on solid chow, with about 60% mortality over the 8 week period.
T3681 16635-16636 . denotes .
T3680 16627-16635 VBN denotes expected
T3679 16624-16626 IN denotes as
T3678 16622-16624 , denotes ,
T3677 16618-16622 NN denotes chow
T3676 16615-16617 IN denotes on
T3675 16606-16614 NN denotes survival
T3674 16604-16605 NN denotes %
T3673 16601-16604 CD denotes 100
T3672 16592-16596 NNS denotes mice
T3671 16587-16591 NN denotes type
T3670 16582-16586 JJ denotes wild
T3669 16580-16582 , denotes ,
T3668 16579-16580 CD denotes 4
T3667 16574-16578 NN denotes Fig.
T3666 16571-16573 IN denotes in
T3665 16597-16600 VBD denotes had
T3664 16565-16570 VBN denotes shown
T3663 16562-16564 IN denotes As
T3662 16561-16636 sentence denotes As shown in Fig. 4, wild type mice had 100% survival on chow, as expected.
T3661 16560-16561 . denotes .
T3660 16555-16560 NNS denotes weeks
T3659 16546-16548 IN denotes to
T3658 16549-16554 CD denotes eight
T3657 16543-16545 IN denotes up
T3656 16539-16542 IN denotes for
T3655 16534-16538 NN denotes chow
T3654 16528-16533 JJ denotes solid
T3653 16525-16527 IN denotes to
T3652 16516-16524 VBN denotes switched
T3651 16511-16515 RB denotes then
T3650 16507-16510 CC denotes and
T3649 16505-16507 , denotes ,
T3648 16502-16505 NN denotes age
T3647 16499-16501 IN denotes of
T3646 16493-16498 NNS denotes weeks
T3645 16491-16492 CD denotes 8
T3644 16485-16490 IN denotes until
T3643 16473-16479 NN denotes liquid
T3642 16480-16484 NN denotes diet
T3641 16469-16472 DT denotes the
T3640 16466-16468 IN denotes on
T3639 16450-16454 VBD denotes were
T3638 16455-16465 VBN denotes maintained
T3637 16445-16449 NNS denotes Mice
T3636 16444-16561 sentence denotes Mice were maintained on the liquid diet until 8 weeks of age, and then switched to solid chow for up to eight weeks.
T3635 16443-16444 . denotes .
T3634 16433-16436 VBD denotes was
T3633 16428-16432 NN denotes chow
T3632 16422-16427 JJ denotes solid
T3631 16419-16421 IN denotes on
T3630 16411-16418 VB denotes survive
T3629 16408-16410 TO denotes to
T3628 16400-16407 NN denotes ability
T3627 16394-16399 PRP$ denotes their
T3626 16392-16394 , denotes ,
T3625 16377-16382 JJ denotes small
T3624 16383-16392 NN denotes intestine
T3623 16373-16376 DT denotes the
T3622 16370-16372 IN denotes in
T3621 16351-16356 NN denotes mucus
T3620 16357-16369 NN denotes accumulation
T3619 16346-16350 JJR denotes less
T3618 16342-16345 CC denotes and
T3617 16328-16330 NN denotes B6
T3616 16331-16341 NN denotes background
T3615 16324-16327 DT denotes the
T3614 16321-16323 IN denotes on
T3613 16316-16320 IN denotes than
T3612 16304-16310 NN denotes weight
T3611 16311-16315 NN denotes gain
T3610 16297-16303 JJR denotes better
T3609 16437-16443 VBN denotes tested
T3608 16276-16281 JJ denotes mixed
T3607 16282-16292 NN denotes background
T3606 16272-16275 DT denotes the
T3605 16269-16271 IN denotes on
T3604 16261-16263 NN denotes CF
T3603 16264-16268 NNS denotes mice
T3601 16293-16296 VBD denotes had
T3600 16251-16256 IN denotes Since
T3599 16250-16444 sentence denotes Since the CF mice on the mixed background had better weight gain than on the B6 background and less mucus accumulation in the small intestine, their ability to survive on solid chow was tested.
T3598 16249-16250 . denotes .
T3597 16248-16249 -RRB- denotes ]
T3596 16246-16248 CD denotes 35
T3595 16245-16246 -LRB- denotes [
T3594 16234-16239 NN denotes mouse
T3593 16228-16233 JJ denotes solid
T3592 16240-16244 NN denotes chow
T3591 16219-16227 JJ denotes standard
T3590 16211-16214 VBP denotes are
T3589 16206-16210 NNS denotes mice
T3588 16202-16205 DT denotes the
T3587 16215-16218 VBN denotes fed
T3586 16197-16201 WRB denotes when
T3585 16185-16187 VBZ denotes is
T3584 16188-16196 VBN denotes worsened
T3602 16257-16260 DT denotes the
T139 0-9 JJ denotes Potential
T140 18-27 NNS denotes modifiers
T141 0-118 sentence denotes Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10
T142 10-17 JJ denotes genetic
T143 28-30 IN denotes of
T144 31-34 DT denotes the
T145 75-84 NN denotes phenotype
T146 35-41 JJ denotes cystic
T147 42-50 NN denotes fibrosis
T148 51-61 JJ denotes intestinal
T149 62-74 JJ denotes inflammatory
T150 85-87 IN denotes on
T151 88-93 NN denotes mouse
T152 106-107 CD denotes 1
T153 94-105 NNS denotes chromosomes
T155 109-110 CD denotes 9
T156 110-112 , denotes ,
T157 112-115 CC denotes and
T158 116-118 CD denotes 10
T159 118-119 sentence denotes
T160 129-139 sentence denotes Background
T161 129-139 NN denotes Background
T162 139-346 sentence denotes Although cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the severity of disease is highly variable indicating the influence of modifier genes.
T163 140-148 IN denotes Although
T164 168-174 VBN denotes caused
T165 149-155 JJ denotes cystic
T166 156-164 NN denotes fibrosis
T167 165-167 VBZ denotes is
T168 284-286 VBZ denotes is
T169 175-177 IN denotes by
T170 178-187 NNS denotes mutations
T171 188-190 IN denotes in
T172 191-194 DT denotes the
T173 254-258 NN denotes gene
T174 195-201 JJ denotes cystic
T175 237-246 NN denotes regulator
T176 202-210 NN denotes fibrosis
T177 211-224 JJ denotes transmembrane
T178 225-236 NN denotes conductance
T179 247-248 -LRB- denotes (
T180 248-252 NN denotes CFTR
T181 252-253 -RRB- denotes )
T182 258-260 , denotes ,
T183 260-263 DT denotes the
T184 264-272 NN denotes severity
T185 273-275 IN denotes of
T186 276-283 NN denotes disease
T187 287-293 RB denotes highly
T188 294-302 JJ denotes variable
T189 303-313 VBG denotes indicating
T190 314-317 DT denotes the
T191 318-327 NN denotes influence
T192 328-330 IN denotes of
T193 331-339 NN denotes modifier
T194 340-345 NNS denotes genes
T195 345-346 . denotes .
T196 346-549 sentence denotes The intestines of Cftr deficient mice (CF mice: Cftrtm1Unc) are prone to obstruction by excessive mucus accumulation and are used as a model of meconium ileus and distal intestinal obstruction syndrome.
T197 347-350 DT denotes The
T198 351-361 NNS denotes intestines
T199 407-410 VBP denotes are
T200 362-364 IN denotes of
T201 365-369 NN denotes Cftr
T202 370-379 JJ denotes deficient
T203 380-384 NNS denotes mice
T204 385-386 -LRB- denotes (
T205 386-388 NN denotes CF
T206 389-393 NNS denotes mice
T207 393-395 : denotes :
T208 395-405 NN denotes Cftrtm1Unc
T209 405-406 -RRB- denotes )
T210 411-416 JJ denotes prone
T211 417-419 IN denotes to
T212 420-431 NN denotes obstruction
T213 432-434 IN denotes by
T214 435-444 JJ denotes excessive
T215 451-463 NN denotes accumulation
T216 445-450 NN denotes mucus
T217 464-467 CC denotes and
T218 468-471 VBP denotes are
T219 472-476 VBN denotes used
T220 477-479 IN denotes as
T221 480-481 DT denotes a
T222 482-487 NN denotes model
T223 488-490 IN denotes of
T224 491-499 NN denotes meconium
T225 500-505 NN denotes ileus
T226 506-509 CC denotes and
T227 510-516 JJ denotes distal
T228 528-539 NN denotes obstruction
T229 517-527 JJ denotes intestinal
T230 540-548 NN denotes syndrome
T231 548-549 . denotes .
T232 549-625 sentence denotes This phenotype is strongly dependent on the genetic background of the mice.
T233 550-554 DT denotes This
T234 555-564 NN denotes phenotype
T235 565-567 VBZ denotes is
T236 568-576 RB denotes strongly
T237 577-586 JJ denotes dependent
T238 587-589 IN denotes on
T239 590-593 DT denotes the
T240 602-612 NN denotes background
T241 594-601 JJ denotes genetic
T242 613-615 IN denotes of
T243 616-619 DT denotes the
T244 620-624 NNS denotes mice
T245 624-625 . denotes .
T246 625-808 sentence denotes On the C57Bl/6 background, the majority of CF mice cannot survive on solid mouse chow, have inflammation of the small intestine, and are about 30% smaller than wild type littermates.
T247 626-628 IN denotes On
T248 684-691 VB denotes survive
T249 629-632 DT denotes the
T250 641-651 NN denotes background
T251 633-638 NN denotes C57Bl
T252 638-639 HYPH denotes /
T253 639-640 CD denotes 6
T254 651-653 , denotes ,
T255 653-656 DT denotes the
T256 657-665 NN denotes majority
T257 666-668 IN denotes of
T258 669-671 NN denotes CF
T259 672-676 NNS denotes mice
T260 677-680 MD denotes can
T261 680-683 RB denotes not
T262 692-694 IN denotes on
T263 695-700 JJ denotes solid
T264 707-711 NN denotes chow
T265 701-706 NN denotes mouse
T266 711-713 , denotes ,
T267 713-717 VBP denotes have
T268 718-730 NN denotes inflammation
T269 731-733 IN denotes of
T270 734-737 DT denotes the
T271 744-753 NN denotes intestine
T272 738-743 JJ denotes small
T273 753-755 , denotes ,
T274 755-758 CC denotes and
T275 759-762 VBP denotes are
T276 763-768 IN denotes about
T277 769-771 CD denotes 30
T278 771-772 NN denotes %
T279 773-780 JJR denotes smaller
T280 781-785 IN denotes than
T281 786-790 JJ denotes wild
T282 791-795 NN denotes type
T283 796-807 NNS denotes littermates
T284 807-808 . denotes .
T285 808-893 sentence denotes In this work potential modifier loci of the CF intestinal phenotype were identified.
T286 809-811 IN denotes In
T287 882-892 VBN denotes identified
T288 812-816 DT denotes this
T289 817-821 NN denotes work
T290 822-831 NN denotes potential
T291 841-845 NNS denotes loci
T292 832-840 NN denotes modifier
T293 846-848 IN denotes of
T294 849-852 DT denotes the
T295 867-876 NN denotes phenotype
T296 853-855 NN denotes CF
T297 856-866 JJ denotes intestinal
T298 877-881 VBD denotes were
T299 892-893 . denotes .
T300 893-902 sentence denotes Results
T301 895-902 NNS denotes Results
T302 902-1082 sentence denotes CF mice on a mixed genetic background (95% C57Bl/6 and 5% 129Sv) were compared to CF mice congenic on the C57Bl/6 background for several parameters of the intestinal CF phenotype.
T303 903-905 NN denotes CF
T304 906-910 NNS denotes mice
T305 973-981 VBN denotes compared
T306 911-913 IN denotes on
T307 914-915 DT denotes a
T308 930-940 NN denotes background
T309 916-921 JJ denotes mixed
T310 922-929 JJ denotes genetic
T311 941-942 -LRB- denotes (
T312 946-951 NN denotes C57Bl
T313 942-944 CD denotes 95
T314 944-945 NN denotes %
T315 951-952 HYPH denotes /
T316 952-953 CD denotes 6
T317 954-957 CC denotes and
T318 958-959 CD denotes 5
T319 961-966 NN denotes 129Sv
T320 959-960 NN denotes %
T321 966-967 -RRB- denotes )
T322 968-972 VBD denotes were
T323 982-984 IN denotes to
T324 985-987 NN denotes CF
T325 988-992 NNS denotes mice
T326 993-1001 JJ denotes congenic
T327 1002-1004 IN denotes on
T328 1005-1008 DT denotes the
T329 1017-1027 NN denotes background
T330 1009-1014 NN denotes C57Bl
T331 1014-1015 HYPH denotes /
T332 1015-1016 CD denotes 6
T333 1028-1031 IN denotes for
T334 1032-1039 JJ denotes several
T335 1040-1050 NNS denotes parameters
T336 1051-1053 IN denotes of
T337 1054-1057 DT denotes the
T338 1072-1081 NN denotes phenotype
T339 1058-1068 JJ denotes intestinal
T340 1069-1071 NN denotes CF
T341 1081-1082 . denotes .
T342 1082-1365 sentence denotes CF mice on the mixed background exhibit significantly greater survival when fed dry mouse chow, have reduced intestinal inflammation as measured by quantitative RT-PCR for marker genes, have near normal body weight gain, and have reduced mucus accumulation in the intestinal crypts.
T343 1083-1085 NN denotes CF
T344 1086-1090 NNS denotes mice
T345 1115-1122 VBP denotes exhibit
T346 1091-1093 IN denotes on
T347 1094-1097 DT denotes the
T348 1104-1114 NN denotes background
T349 1098-1103 JJ denotes mixed
T350 1123-1136 RB denotes significantly
T351 1137-1144 JJR denotes greater
T352 1145-1153 NN denotes survival
T353 1154-1158 WRB denotes when
T354 1159-1162 VBN denotes fed
T355 1163-1166 JJ denotes dry
T356 1173-1177 NN denotes chow
T357 1167-1172 NN denotes mouse
T358 1177-1179 , denotes ,
T359 1179-1183 VBP denotes have
T360 1184-1191 VBN denotes reduced
T361 1203-1215 NN denotes inflammation
T362 1192-1202 JJ denotes intestinal
T363 1216-1218 IN denotes as
T364 1219-1227 VBN denotes measured
T365 1228-1230 IN denotes by
T366 1231-1243 JJ denotes quantitative
T367 1247-1250 NN denotes PCR
T368 1244-1246 NN denotes RT
T369 1246-1247 HYPH denotes -
T370 1251-1254 IN denotes for
T371 1255-1261 NN denotes marker
T372 1262-1267 NNS denotes genes
T373 1267-1269 , denotes ,
T374 1269-1273 VBP denotes have
T375 1274-1278 RB denotes near
T376 1279-1285 JJ denotes normal
T377 1298-1302 NN denotes gain
T378 1286-1290 NN denotes body
T379 1291-1297 NN denotes weight
T380 1302-1304 , denotes ,
T381 1304-1307 CC denotes and
T382 1308-1312 VBP denotes have
T383 1313-1320 VBN denotes reduced
T384 1327-1339 NN denotes accumulation
T385 1321-1326 NN denotes mucus
T386 1340-1342 IN denotes in
T387 1343-1346 DT denotes the
T388 1358-1364 NNS denotes crypts
T389 1347-1357 JJ denotes intestinal
T390 1364-1365 . denotes .
T391 1365-1588 sentence denotes There was an indication of a gender effect for body weight gain: males did not show a significant improvement at 4 weeks of age, but were of normal weight at 8 weeks, while females showed improvement at both 4 and 8 weeks.
T392 1366-1371 EX denotes There
T393 1372-1375 VBD denotes was
T394 1445-1449 VB denotes show
T395 1376-1378 DT denotes an
T396 1379-1389 NN denotes indication
T397 1390-1392 IN denotes of
T398 1393-1394 DT denotes a
T399 1402-1408 NN denotes effect
T400 1395-1401 NN denotes gender
T401 1409-1412 IN denotes for
T402 1413-1417 NN denotes body
T403 1425-1429 NN denotes gain
T404 1418-1424 NN denotes weight
T405 1429-1431 : denotes :
T406 1431-1436 NNS denotes males
T407 1437-1440 VBD denotes did
T408 1441-1444 RB denotes not
T409 1450-1451 DT denotes a
T410 1464-1475 NN denotes improvement
T411 1452-1463 JJ denotes significant
T412 1476-1478 IN denotes at
T413 1479-1480 CD denotes 4
T414 1481-1486 NNS denotes weeks
T415 1487-1489 IN denotes of
T416 1490-1493 NN denotes age
T417 1493-1495 , denotes ,
T418 1495-1498 CC denotes but
T419 1499-1503 VBD denotes were
T420 1504-1506 IN denotes of
T421 1507-1513 JJ denotes normal
T422 1514-1520 NN denotes weight
T423 1521-1523 IN denotes at
T424 1524-1525 CD denotes 8
T425 1526-1531 NNS denotes weeks
T426 1531-1533 , denotes ,
T427 1533-1538 IN denotes while
T428 1547-1553 VBD denotes showed
T429 1539-1546 NNS denotes females
T430 1554-1565 NN denotes improvement
T431 1566-1568 IN denotes at
T432 1569-1573 CC denotes both
T433 1574-1575 CD denotes 4
T434 1582-1587 NNS denotes weeks
T435 1576-1579 CC denotes and
T436 1580-1581 CD denotes 8
T437 1587-1588 . denotes .
T438 1588-1719 sentence denotes By a preliminary genome-wide PCR allele scanning, three regions were found to be potentially associated with the milder phenotype.
T439 1589-1591 IN denotes By
T440 1658-1663 VBN denotes found
T441 1592-1593 DT denotes a
T442 1629-1637 NN denotes scanning
T443 1594-1605 JJ denotes preliminary
T444 1606-1612 NN denotes genome
T445 1613-1617 JJ denotes wide
T446 1612-1613 HYPH denotes -
T447 1618-1621 NN denotes PCR
T448 1622-1628 NN denotes allele
T449 1637-1639 , denotes ,
T450 1639-1644 CD denotes three
T451 1645-1652 NNS denotes regions
T452 1653-1657 VBD denotes were
T453 1664-1666 TO denotes to
T454 1682-1692 VBN denotes associated
T455 1667-1669 VB denotes be
T456 1670-1681 RB denotes potentially
T457 1693-1697 IN denotes with
T458 1698-1701 DT denotes the
T459 1709-1718 NN denotes phenotype
T460 1702-1708 JJR denotes milder
T461 1718-1719 . denotes .
T462 1719-1849 sentence denotes One on chr.1, defined by marker D1Mit36, one on chr. 9 defined by marker D9Mit90, and one on chr. 10, defined by marker D10Mit14.
T463 1720-1723 CD denotes One
T464 1724-1726 IN denotes on
T465 1727-1732 NN denotes chr.1
T466 1732-1734 , denotes ,
T467 1734-1741 VBN denotes defined
T468 1742-1744 IN denotes by
T469 1745-1751 NN denotes marker
T470 1752-1759 NN denotes D1Mit36
T471 1759-1761 , denotes ,
T472 1761-1764 CD denotes one
T473 1765-1767 IN denotes on
T474 1768-1772 NN denotes chr.
T475 1773-1774 CD denotes 9
T476 1775-1782 VBN denotes defined
T477 1783-1785 IN denotes by
T478 1786-1792 NN denotes marker
T479 1793-1800 NN denotes D9Mit90
T480 1800-1802 , denotes ,
T481 1802-1805 CC denotes and
T482 1806-1809 CD denotes one
T483 1810-1812 IN denotes on
T484 1813-1817 NN denotes chr.
T485 1818-1820 CD denotes 10
T486 1820-1822 , denotes ,
T487 1822-1829 VBN denotes defined
T488 1830-1832 IN denotes by
T489 1833-1839 NN denotes marker
T490 1840-1848 NN denotes D10Mit14
T491 1848-1849 . denotes .
T492 1849-1861 sentence denotes Conclusion
T493 1851-1861 NN denotes Conclusion
T494 1861-2010 sentence denotes Potential modifier regions were found that have a positive impact on the inflammatory phenotype of the CF mouse small intestine and animal survival.
T495 1862-1871 JJ denotes Potential
T496 1881-1888 NNS denotes regions
T497 1872-1880 NN denotes modifier
T498 1894-1899 VBN denotes found
T499 1889-1893 VBD denotes were
T500 1900-1904 WDT denotes that
T501 1905-1909 VBP denotes have
T502 1910-1911 DT denotes a
T503 1921-1927 NN denotes impact
T504 1912-1920 JJ denotes positive
T505 1928-1930 IN denotes on
T506 1931-1934 DT denotes the
T507 1948-1957 NN denotes phenotype
T508 1935-1947 JJ denotes inflammatory
T509 1958-1960 IN denotes of
T510 1961-1964 DT denotes the
T511 1980-1989 NN denotes intestine
T512 1965-1967 NN denotes CF
T513 1968-1973 NN denotes mouse
T514 1974-1979 JJ denotes small
T515 1990-1993 CC denotes and
T516 1994-2000 NN denotes animal
T517 2001-2009 NN denotes survival
T518 2009-2010 . denotes .
T519 2010-2174 sentence denotes Identification of polymorphisms in specific genes in these regions should provide important new information about genetic modifiers of the CF intestinal phenotype.
T520 2011-2025 NN denotes Identification
T521 2085-2092 VB denotes provide
T522 2026-2028 IN denotes of
T523 2029-2042 NNS denotes polymorphisms
T524 2043-2045 IN denotes in
T525 2046-2054 JJ denotes specific
T526 2055-2060 NNS denotes genes
T527 2061-2063 IN denotes in
T528 2064-2069 DT denotes these
T529 2070-2077 NNS denotes regions
T530 2078-2084 MD denotes should
T531 2093-2102 JJ denotes important
T532 2107-2118 NN denotes information
T533 2103-2106 JJ denotes new
T534 2119-2124 IN denotes about
T535 2125-2132 JJ denotes genetic
T536 2133-2142 NNS denotes modifiers
T537 2143-2145 IN denotes of
T538 2146-2149 DT denotes the
T539 2164-2173 NN denotes phenotype
T540 2150-2152 NN denotes CF
T541 2153-2163 JJ denotes intestinal
T542 2173-2174 . denotes .
T795 2231-2233 IN denotes in
T796 2234-2237 DT denotes the
T797 2297-2301 NN denotes gene
T798 2238-2244 JJ denotes cystic
T799 2245-2253 NN denotes fibrosis
T800 2280-2289 NN denotes regulator
T801 2254-2267 JJ denotes transmembrane
T802 2268-2279 NN denotes conductance
T803 2290-2291 -LRB- denotes (
T804 2291-2295 NN denotes CFTR
T805 2295-2296 -RRB- denotes )
T806 2302-2303 -LRB- denotes [
T807 2303-2304 CD denotes 1
T808 2304-2305 -RRB- denotes ]
T809 2305-2306 . denotes .
T810 2306-2455 sentence denotes Different mutations have a range of effects on the levels of CFTR protein and its proper functioning in epithelial transport of Cl- and HCO3- [2,3].
T811 2307-2316 JJ denotes Different
T812 2317-2326 NNS denotes mutations
T813 2327-2331 VBP denotes have
T814 2332-2333 DT denotes a
T815 2334-2339 NN denotes range
T816 2340-2342 IN denotes of
T817 2343-2350 NNS denotes effects
T818 2351-2353 IN denotes on
T819 2354-2357 DT denotes the
T820 2358-2364 NNS denotes levels
T821 2365-2367 IN denotes of
T822 2368-2372 NN denotes CFTR
T823 2373-2380 NN denotes protein
T824 2381-2384 CC denotes and
T825 2385-2388 PRP$ denotes its
T826 2396-2407 NN denotes functioning
T827 2389-2395 JJ denotes proper
T828 2408-2410 IN denotes in
T829 2411-2421 JJ denotes epithelial
T830 2422-2431 NN denotes transport
T831 2432-2434 IN denotes of
T832 2435-2437 NN denotes Cl
T833 2437-2438 SYM denotes -
T834 2439-2442 CC denotes and
T835 2443-2447 NN denotes HCO3
T836 2447-2448 SYM denotes -
T837 2449-2450 -LRB- denotes [
T838 2452-2453 CD denotes 3
T839 2450-2451 CD denotes 2
T840 2451-2452 , denotes ,
T841 2453-2454 -RRB- denotes ]
T842 2454-2455 . denotes .
T843 2455-2599 sentence denotes The severity of the pancreatic phenotype in human CF is well correlated with the extent of impaired CFTR function caused by specific mutations.
T844 2456-2459 DT denotes The
T845 2460-2468 NN denotes severity
T846 2509-2511 VBZ denotes is
T847 2469-2471 IN denotes of
T848 2472-2475 DT denotes the
T849 2487-2496 NN denotes phenotype
T850 2476-2486 JJ denotes pancreatic
T851 2497-2499 IN denotes in
T852 2500-2505 JJ denotes human
T853 2506-2508 NN denotes CF
T854 2512-2516 RB denotes well
T855 2517-2527 JJ denotes correlated
T856 2528-2532 IN denotes with
T857 2533-2536 DT denotes the
T858 2537-2543 NN denotes extent
T859 2544-2546 IN denotes of
T860 2547-2555 JJ denotes impaired
T861 2561-2569 NN denotes function
T862 2556-2560 NN denotes CFTR
T863 2570-2576 VBN denotes caused
T864 2577-2579 IN denotes by
T865 2580-2588 JJ denotes specific
T866 2589-2598 NNS denotes mutations
T867 2598-2599 . denotes .
T868 2599-2706 sentence denotes Loss of CFTR function results in destruction of the exocrine tissue and eventual pancreatic insufficiency.
T869 2600-2604 NN denotes Loss
T870 2622-2629 VBZ denotes results
T871 2605-2607 IN denotes of
T872 2608-2612 NN denotes CFTR
T873 2613-2621 NN denotes function
T874 2630-2632 IN denotes in
T875 2633-2644 NN denotes destruction
T876 2645-2647 IN denotes of
T877 2648-2651 DT denotes the
T878 2661-2667 NN denotes tissue
T879 2652-2660 NN denotes exocrine
T880 2668-2671 CC denotes and
T881 2672-2680 JJ denotes eventual
T882 2692-2705 NN denotes insufficiency
T883 2681-2691 JJ denotes pancreatic
T884 2705-2706 . denotes .
T885 2706-2893 sentence denotes On the other hand, the effects of CF on organs including the airways and intestines is less well correlated with specific CFTR mutations and their effects on CFTR protein function [4-8].
T886 2707-2709 IN denotes On
T887 2791-2793 VBZ denotes is
T888 2710-2713 DT denotes the
T889 2720-2724 NN denotes hand
T890 2714-2719 JJ denotes other
T891 2724-2726 , denotes ,
T892 2726-2729 DT denotes the
T893 2730-2737 NNS denotes effects
T894 2738-2740 IN denotes of
T895 2741-2743 NN denotes CF
T896 2744-2746 IN denotes on
T897 2747-2753 NNS denotes organs
T898 2754-2763 VBG denotes including
T899 2764-2767 DT denotes the
T900 2768-2775 NNS denotes airways
T901 2776-2779 CC denotes and
T902 2780-2790 NNS denotes intestines
T903 2794-2798 RBR denotes less
T904 2804-2814 JJ denotes correlated
T905 2799-2803 RB denotes well
T906 2815-2819 IN denotes with
T907 2820-2828 JJ denotes specific
T908 2834-2843 NNS denotes mutations
T909 2829-2833 NN denotes CFTR
T910 2844-2847 CC denotes and
T911 2848-2853 PRP$ denotes their
T912 2854-2861 NNS denotes effects
T913 2862-2864 IN denotes on
T914 2865-2869 NN denotes CFTR
T915 2878-2886 NN denotes function
T916 2870-2877 NN denotes protein
T917 2887-2888 -LRB- denotes [
T918 2888-2889 CD denotes 4
T919 2889-2890 SYM denotes -
T920 2890-2891 CD denotes 8
T921 2891-2892 -RRB- denotes ]
T922 2892-2893 . denotes .
T923 2893-2986 sentence denotes This indicates that other genes are likely to be important as modifiers of the CF phenotype.
T924 2894-2898 DT denotes This
T925 2899-2908 VBZ denotes indicates
T926 2909-2913 IN denotes that
T927 2926-2929 VBP denotes are
T928 2914-2919 JJ denotes other
T929 2920-2925 NNS denotes genes
T930 2930-2936 JJ denotes likely
T931 2937-2939 TO denotes to
T932 2940-2942 VB denotes be
T933 2943-2952 JJ denotes important
T934 2953-2955 IN denotes as
T935 2956-2965 NNS denotes modifiers
T936 2966-2968 IN denotes of
T937 2969-2972 DT denotes the
T938 2976-2985 NN denotes phenotype
T939 2973-2975 NN denotes CF
T940 2985-2986 . denotes .
T941 2986-3137 sentence denotes With the exception of pancreatic insufficiency resulting in impaired digestion, other aspects of CF are less readily related to loss of CFTR function.
T942 2987-2991 IN denotes With
T943 3087-3090 VBP denotes are
T944 2992-2995 DT denotes the
T945 2996-3005 NN denotes exception
T946 3006-3008 IN denotes of
T947 3009-3019 JJ denotes pancreatic
T948 3020-3033 NN denotes insufficiency
T949 3034-3043 VBG denotes resulting
T950 3044-3046 IN denotes in
T951 3047-3055 VBN denotes impaired
T952 3056-3065 NN denotes digestion
T953 3065-3067 , denotes ,
T954 3067-3072 JJ denotes other
T955 3073-3080 NNS denotes aspects
T956 3081-3083 IN denotes of
T957 3084-3086 NN denotes CF
T958 3091-3095 RBR denotes less
T959 3096-3103 RB denotes readily
T960 3104-3111 JJ denotes related
T961 3112-3114 IN denotes to
T962 3115-3119 NN denotes loss
T963 3120-3122 IN denotes of
T964 3123-3127 NN denotes CFTR
T965 3128-3136 NN denotes function
T966 3136-3137 . denotes .
T967 3137-3363 sentence denotes Nutritional problems can persist even with adequate oral enzyme supplementation [9] and neutralization of gastric acid to improve lipase function [10], and may involve both impaired digestion and absorption of nutrients [11].
T968 3138-3149 JJ denotes Nutritional
T969 3150-3158 NNS denotes problems
T970 3163-3170 VB denotes persist
T971 3159-3162 MD denotes can
T972 3171-3175 RB denotes even
T973 3176-3180 IN denotes with
T974 3181-3189 JJ denotes adequate
T975 3202-3217 NN denotes supplementation
T976 3190-3194 JJ denotes oral
T977 3195-3201 NN denotes enzyme
T978 3218-3219 -LRB- denotes [
T979 3219-3220 CD denotes 9
T980 3220-3221 -RRB- denotes ]
T981 3222-3225 CC denotes and
T982 3226-3240 NN denotes neutralization
T983 3241-3243 IN denotes of
T984 3244-3251 JJ denotes gastric
T985 3252-3256 NN denotes acid
T986 3257-3259 TO denotes to
T987 3260-3267 VB denotes improve
T988 3268-3274 NN denotes lipase
T989 3275-3283 NN denotes function
T990 3284-3285 -LRB- denotes [
T991 3285-3287 CD denotes 10
T992 3287-3288 -RRB- denotes ]
T993 3288-3290 , denotes ,
T994 3290-3293 CC denotes and
T995 3294-3297 MD denotes may
T996 3298-3305 VB denotes involve
T997 3306-3310 CC denotes both
T998 3320-3329 NN denotes digestion
T999 3311-3319 JJ denotes impaired
T1000 3330-3333 CC denotes and
T1001 3334-3344 NN denotes absorption
T1002 3345-3347 IN denotes of
T1003 3348-3357 NNS denotes nutrients
T1004 3358-3359 -LRB- denotes [
T1005 3359-3361 CD denotes 11
T1006 3361-3362 -RRB- denotes ]
T1007 3362-3363 . denotes .
T1008 3363-3547 sentence denotes Inadequate absorption or assimilation of nutrients appears to be of greater importance because even with adequate oral enzyme supplementation nutrition is rarely fully corrected [11].
T1009 3364-3374 JJ denotes Inadequate
T1010 3375-3385 NN denotes absorption
T1011 3415-3422 VBZ denotes appears
T1012 3386-3388 CC denotes or
T1013 3389-3401 NN denotes assimilation
T1014 3402-3404 IN denotes of
T1015 3405-3414 NNS denotes nutrients
T1016 3423-3425 TO denotes to
T1017 3426-3428 VB denotes be
T1018 3429-3431 IN denotes of
T1019 3432-3439 JJR denotes greater
T1020 3440-3450 NN denotes importance
T1021 3451-3458 IN denotes because
T1022 3532-3541 VBN denotes corrected
T1023 3459-3463 RB denotes even
T1024 3464-3468 IN denotes with
T1025 3469-3477 JJ denotes adequate
T1026 3490-3505 NN denotes supplementation
T1027 3478-3482 JJ denotes oral
T1028 3483-3489 NN denotes enzyme
T1029 3506-3515 NN denotes nutrition
T1030 3516-3518 VBZ denotes is
T1031 3519-3525 RB denotes rarely
T1032 3526-3531 RB denotes fully
T1033 3542-3543 -LRB- denotes [
T1034 3543-3545 CD denotes 11
T1035 3545-3546 -RRB- denotes ]
T1036 3546-3547 . denotes .
T1037 3547-3658 sentence denotes There is also excessive mucus accumulation in the CF intestine, and inappropriate inflammation is common [12].
T1038 3548-3553 EX denotes There
T1039 3554-3556 VBZ denotes is
T1040 3557-3561 RB denotes also
T1041 3562-3571 JJ denotes excessive
T1042 3578-3590 NN denotes accumulation
T1043 3572-3577 NN denotes mucus
T1044 3591-3593 IN denotes in
T1045 3594-3597 DT denotes the
T1046 3601-3610 NN denotes intestine
T1047 3598-3600 NN denotes CF
T1048 3610-3612 , denotes ,
T1049 3612-3615 CC denotes and
T1050 3616-3629 JJ denotes inappropriate
T1051 3630-3642 NN denotes inflammation
T1052 3643-3645 VBZ denotes is
T1053 3646-3652 JJ denotes common
T1054 3653-3654 -LRB- denotes [
T1055 3654-3656 CD denotes 12
T1056 3656-3657 -RRB- denotes ]
T1057 3657-3658 . denotes .
T1058 3658-3842 sentence denotes Mucus is involved in obstruction of the gut which occurs frequently in CF infants (called meconium ileus, MI) and adults (called distal intestinal obstruction syndrome, DIOS) [11,13].
T1059 3659-3664 NN denotes Mucus
T1060 3668-3676 VBN denotes involved
T1061 3665-3667 VBZ denotes is
T1062 3677-3679 IN denotes in
T1063 3680-3691 NN denotes obstruction
T1064 3692-3694 IN denotes of
T1065 3695-3698 DT denotes the
T1066 3699-3702 NN denotes gut
T1067 3703-3708 WDT denotes which
T1068 3709-3715 VBZ denotes occurs
T1069 3716-3726 RB denotes frequently
T1070 3727-3729 IN denotes in
T1071 3730-3732 NN denotes CF
T1072 3733-3740 NNS denotes infants
T1073 3741-3742 -LRB- denotes (
T1074 3742-3748 VBN denotes called
T1075 3749-3757 NN denotes meconium
T1076 3758-3763 NN denotes ileus
T1077 3763-3765 , denotes ,
T1078 3765-3767 NN denotes MI
T1079 3767-3768 -RRB- denotes )
T1080 3769-3772 CC denotes and
T1081 3773-3779 NNS denotes adults
T1082 3780-3781 -LRB- denotes (
T1083 3781-3787 VBN denotes called
T1084 3788-3794 JJ denotes distal
T1085 3818-3826 NN denotes syndrome
T1086 3795-3805 JJ denotes intestinal
T1087 3806-3817 NN denotes obstruction
T1088 3826-3828 , denotes ,
T1089 3828-3832 NN denotes DIOS
T1090 3832-3833 -RRB- denotes )
T1091 3834-3835 -LRB- denotes [
T1092 3838-3840 CD denotes 13
T1093 3835-3837 CD denotes 11
T1094 3837-3838 , denotes ,
T1095 3840-3841 -RRB- denotes ]
T1096 3841-3842 . denotes .
T1097 3842-3930 sentence denotes And, similar to CF airways, there is also an inflammation of the CF intestines [14,15].
T1098 3843-3846 CC denotes And
T1099 3877-3879 VBZ denotes is
T1100 3846-3848 , denotes ,
T1101 3848-3855 JJ denotes similar
T1102 3856-3858 IN denotes to
T1103 3859-3861 NN denotes CF
T1104 3862-3869 NNS denotes airways
T1105 3869-3871 , denotes ,
T1106 3871-3876 EX denotes there
T1107 3880-3884 RB denotes also
T1108 3885-3887 DT denotes an
T1109 3888-3900 NN denotes inflammation
T1110 3901-3903 IN denotes of
T1111 3904-3907 DT denotes the
T1112 3911-3921 NNS denotes intestines
T1113 3908-3910 NN denotes CF
T1114 3922-3923 -LRB- denotes [
T1115 3926-3928 CD denotes 15
T1116 3923-3925 CD denotes 14
T1117 3925-3926 , denotes ,
T1118 3928-3929 -RRB- denotes ]
T1119 3929-3930 . denotes .
T1120 3930-4083 sentence denotes These changes are less directly related to specific mutations in the CFTR gene and are likely related to other differences in individual genetic makeup.
T1121 3931-3936 DT denotes These
T1122 3937-3944 NNS denotes changes
T1123 3945-3948 VBP denotes are
T1124 3949-3953 RBR denotes less
T1125 3954-3962 RB denotes directly
T1126 3963-3970 JJ denotes related
T1127 3971-3973 IN denotes to
T1128 3974-3982 JJ denotes specific
T1129 3983-3992 NNS denotes mutations
T1130 3993-3995 IN denotes in
T1131 3996-3999 DT denotes the
T1132 4005-4009 NN denotes gene
T1133 4000-4004 NN denotes CFTR
T1134 4010-4013 CC denotes and
T1135 4014-4017 VBP denotes are
T1136 4018-4024 RB denotes likely
T1137 4025-4032 JJ denotes related
T1138 4033-4035 IN denotes to
T1139 4036-4041 JJ denotes other
T1140 4042-4053 NNS denotes differences
T1141 4054-4056 IN denotes in
T1142 4057-4067 JJ denotes individual
T1143 4076-4082 NN denotes makeup
T1144 4068-4075 JJ denotes genetic
T1145 4082-4083 . denotes .
T1146 4083-4245 sentence denotes Previous work using human patients and genetically altered mice has identified some modifier genes and have advanced our understanding of CF pathophysiology [4].
T1147 4084-4092 JJ denotes Previous
T1148 4093-4097 NN denotes work
T1149 4152-4162 VBN denotes identified
T1150 4098-4103 VBG denotes using
T1151 4104-4109 JJ denotes human
T1152 4110-4118 NNS denotes patients
T1153 4119-4122 CC denotes and
T1154 4123-4134 RB denotes genetically
T1155 4135-4142 VBN denotes altered
T1156 4143-4147 NNS denotes mice
T1157 4148-4151 VBZ denotes has
T1158 4163-4167 DT denotes some
T1159 4177-4182 NNS denotes genes
T1160 4168-4176 NN denotes modifier
T1161 4183-4186 CC denotes and
T1162 4187-4191 VBP denotes have
T1163 4192-4200 VBN denotes advanced
T1164 4201-4204 PRP$ denotes our
T1165 4205-4218 NN denotes understanding
T1166 4219-4221 IN denotes of
T1167 4222-4224 NN denotes CF
T1168 4225-4240 NN denotes pathophysiology
T1169 4241-4242 -LRB- denotes [
T1170 4242-4243 CD denotes 4
T1171 4243-4244 -RRB- denotes ]
T1172 4244-4245 . denotes .
T1173 4245-4499 sentence denotes In one study using CF mice on different genetic backgrounds, a region on mouse chromosome 7 was shown to ameliorate intestinal blockage and the effect was in part due to a calcium-regulated Cl-channel which compensated for loss of CFTR function [16,17].
T1174 4246-4248 IN denotes In
T1175 4342-4347 VBN denotes shown
T1176 4249-4252 CD denotes one
T1177 4253-4258 NN denotes study
T1178 4259-4264 VBG denotes using
T1179 4265-4267 NN denotes CF
T1180 4268-4272 NNS denotes mice
T1181 4273-4275 IN denotes on
T1182 4276-4285 JJ denotes different
T1183 4294-4305 NNS denotes backgrounds
T1184 4286-4293 JJ denotes genetic
T1185 4305-4307 , denotes ,
T1186 4307-4308 DT denotes a
T1187 4309-4315 NN denotes region
T1188 4316-4318 IN denotes on
T1189 4319-4324 NN denotes mouse
T1190 4325-4335 NN denotes chromosome
T1191 4336-4337 CD denotes 7
T1192 4338-4341 VBD denotes was
T1193 4348-4350 TO denotes to
T1194 4351-4361 VB denotes ameliorate
T1195 4362-4372 JJ denotes intestinal
T1196 4373-4381 NN denotes blockage
T1197 4382-4385 CC denotes and
T1198 4386-4389 DT denotes the
T1199 4390-4396 NN denotes effect
T1200 4397-4400 VBD denotes was
T1201 4401-4403 IN denotes in
T1202 4404-4408 JJ denotes part
T1203 4409-4412 IN denotes due
T1204 4413-4415 IN denotes to
T1205 4416-4417 DT denotes a
T1206 4439-4446 NN denotes channel
T1207 4418-4425 NN denotes calcium
T1208 4426-4435 VBN denotes regulated
T1209 4425-4426 HYPH denotes -
T1210 4436-4438 NN denotes Cl
T1211 4438-4439 SYM denotes -
T1212 4447-4452 WDT denotes which
T1213 4453-4464 VBD denotes compensated
T1214 4465-4468 IN denotes for
T1215 4469-4473 NN denotes loss
T1216 4474-4476 IN denotes of
T1217 4477-4481 NN denotes CFTR
T1218 4482-4490 NN denotes function
T1219 4491-4492 -LRB- denotes [
T1220 4495-4497 CD denotes 17
T1221 4492-4494 CD denotes 16
T1222 4494-4495 , denotes ,
T1223 4497-4498 -RRB- denotes ]
T1224 4498-4499 . denotes .
T1225 4499-4640 sentence denotes Marker haplotypes of the syntenic region of human chromosome 19q13 were also shown to be associated with the risk of MI in CF patients [18].
T1226 4500-4506 NN denotes Marker
T1227 4507-4517 NNS denotes haplotypes
T1228 4577-4582 VBN denotes shown
T1229 4518-4520 IN denotes of
T1230 4521-4524 DT denotes the
T1231 4534-4540 NN denotes region
T1232 4525-4533 JJ denotes syntenic
T1233 4541-4543 IN denotes of
T1234 4544-4549 JJ denotes human
T1235 4550-4560 NN denotes chromosome
T1236 4561-4566 CD denotes 19q13
T1237 4567-4571 VBD denotes were
T1238 4572-4576 RB denotes also
T1239 4583-4585 TO denotes to
T1240 4589-4599 VBN denotes associated
T1241 4586-4588 VB denotes be
T1242 4600-4604 IN denotes with
T1243 4605-4608 DT denotes the
T1244 4609-4613 NN denotes risk
T1245 4614-4616 IN denotes of
T1246 4617-4619 NN denotes MI
T1247 4620-4622 IN denotes in
T1248 4623-4625 NN denotes CF
T1249 4626-4634 NNS denotes patients
T1250 4635-4636 -LRB- denotes [
T1251 4636-4638 CD denotes 18
T1252 4638-4639 -RRB- denotes ]
T1253 4639-4640 . denotes .
T1254 4640-4906 sentence denotes In other work, a region on mouse chr. 6 was strongly associated with lung inflammation, consisting of mononuclear cell interstitial infiltration and fibrosis in CF mouse airways; and other loci on chr. 1, 2, 10, and 17 were also linked to the airway phenotype [19].
T1255 4641-4643 IN denotes In
T1256 4694-4704 VBN denotes associated
T1257 4644-4649 JJ denotes other
T1258 4650-4654 NN denotes work
T1259 4654-4656 , denotes ,
T1260 4656-4657 DT denotes a
T1261 4658-4664 NN denotes region
T1262 4665-4667 IN denotes on
T1263 4668-4673 NN denotes mouse
T1264 4674-4678 NN denotes chr.
T1265 4679-4680 CD denotes 6
T1266 4681-4684 VBD denotes was
T1267 4685-4693 RB denotes strongly
T1268 4705-4709 IN denotes with
T1269 4710-4714 NN denotes lung
T1270 4715-4727 NN denotes inflammation
T1271 4727-4729 , denotes ,
T1272 4729-4739 VBG denotes consisting
T1273 4740-4742 IN denotes of
T1274 4743-4754 JJ denotes mononuclear
T1275 4755-4759 NN denotes cell
T1276 4773-4785 NN denotes infiltration
T1277 4760-4772 JJ denotes interstitial
T1278 4786-4789 CC denotes and
T1279 4790-4798 NN denotes fibrosis
T1280 4799-4801 IN denotes in
T1281 4802-4804 NN denotes CF
T1282 4811-4818 NNS denotes airways
T1283 4805-4810 NN denotes mouse
T1284 4818-4819 : denotes ;
T1285 4820-4823 CC denotes and
T1286 4824-4829 JJ denotes other
T1287 4830-4834 NNS denotes loci
T1288 4870-4876 VBN denotes linked
T1289 4835-4837 IN denotes on
T1290 4838-4842 NN denotes chr.
T1291 4843-4844 CD denotes 1
T1292 4844-4846 , denotes ,
T1293 4846-4847 CD denotes 2
T1294 4847-4849 , denotes ,
T1295 4849-4851 CD denotes 10
T1296 4851-4853 , denotes ,
T1297 4853-4856 CC denotes and
T1298 4857-4859 CD denotes 17
T1299 4860-4864 VBD denotes were
T1300 4865-4869 RB denotes also
T1301 4877-4879 IN denotes to
T1302 4880-4883 DT denotes the
T1303 4891-4900 NN denotes phenotype
T1304 4884-4890 NN denotes airway
T1305 4901-4902 -LRB- denotes [
T1306 4902-4904 CD denotes 19
T1307 4904-4905 -RRB- denotes ]
T1308 4905-4906 . denotes .
T1309 4906-5059 sentence denotes In this work, CF mice on a mixed strain background were found to have a less severe CF phenotype compared to CF mice congenic on the C57Bl/6 background.
T1310 4907-4909 IN denotes In
T1311 4963-4968 VBN denotes found
T1312 4910-4914 DT denotes this
T1313 4915-4919 NN denotes work
T1314 4919-4921 , denotes ,
T1315 4921-4923 NN denotes CF
T1316 4924-4928 NNS denotes mice
T1317 4929-4931 IN denotes on
T1318 4932-4933 DT denotes a
T1319 4947-4957 NN denotes background
T1320 4934-4939 JJ denotes mixed
T1321 4940-4946 NN denotes strain
T1322 4958-4962 VBD denotes were
T1323 4969-4971 TO denotes to
T1324 4972-4976 VB denotes have
T1325 4977-4978 DT denotes a
T1326 4994-5003 NN denotes phenotype
T1327 4979-4983 RBR denotes less
T1328 4984-4990 JJ denotes severe
T1329 4991-4993 NN denotes CF
T1330 5004-5012 VBN denotes compared
T1331 5013-5015 IN denotes to
T1332 5016-5018 NN denotes CF
T1333 5019-5023 NNS denotes mice
T1334 5024-5032 JJ denotes congenic
T1335 5033-5035 IN denotes on
T1336 5036-5039 DT denotes the
T1337 5048-5058 NN denotes background
T1338 5040-5045 NN denotes C57Bl
T1339 5045-5046 HYPH denotes /
T1340 5046-5047 CD denotes 6
T1341 5058-5059 . denotes .
T1342 5059-5166 sentence denotes There were no differences in the pancreatic phenotype comparing CF mice on the different backgrounds [20].
T1343 5060-5065 EX denotes There
T1344 5066-5070 VBD denotes were
T1345 5071-5073 DT denotes no
T1346 5074-5085 NNS denotes differences
T1347 5086-5088 IN denotes in
T1348 5089-5092 DT denotes the
T1349 5104-5113 NN denotes phenotype
T1350 5093-5103 JJ denotes pancreatic
T1351 5114-5123 VBG denotes comparing
T1352 5124-5126 NN denotes CF
T1353 5127-5131 NNS denotes mice
T1354 5132-5134 IN denotes on
T1355 5135-5138 DT denotes the
T1356 5149-5160 NNS denotes backgrounds
T1357 5139-5148 JJ denotes different
T1358 5161-5162 -LRB- denotes [
T1359 5162-5164 CD denotes 20
T1360 5164-5165 -RRB- denotes ]
T1361 5165-5166 . denotes .
T1362 5166-5315 sentence denotes However, mice on the mixed background seemed more robust than CF mice on the B6 background which prompted us to characterize them in greater detail.
T1363 5167-5174 RB denotes However
T1364 5205-5211 VBD denotes seemed
T1365 5174-5176 , denotes ,
T1366 5176-5180 NNS denotes mice
T1367 5181-5183 IN denotes on
T1368 5184-5187 DT denotes the
T1369 5194-5204 NN denotes background
T1370 5188-5193 JJ denotes mixed
T1371 5212-5216 RBR denotes more
T1372 5217-5223 JJ denotes robust
T1373 5224-5228 IN denotes than
T1374 5229-5231 NN denotes CF
T1375 5232-5236 NNS denotes mice
T1376 5237-5239 IN denotes on
T1377 5240-5243 DT denotes the
T1378 5247-5257 NN denotes background
T1379 5244-5246 NN denotes B6
T1380 5258-5263 WDT denotes which
T1381 5264-5272 VBD denotes prompted
T1382 5273-5275 PRP denotes us
T1383 5276-5278 TO denotes to
T1384 5279-5291 VB denotes characterize
T1385 5292-5296 PRP denotes them
T1386 5297-5299 IN denotes in
T1387 5300-5307 JJR denotes greater
T1388 5308-5314 NN denotes detail
T1389 5314-5315 . denotes .
T1390 5315-5441 sentence denotes Genome wide allele scanning was used to begin identification of regions associated with the less severe intestinal phenotype.
T1391 5316-5322 NN denotes Genome
T1392 5323-5327 JJ denotes wide
T1393 5335-5343 NN denotes scanning
T1394 5328-5334 NN denotes allele
T1395 5348-5352 VBN denotes used
T1396 5344-5347 VBD denotes was
T1397 5353-5355 TO denotes to
T1398 5356-5361 VB denotes begin
T1399 5362-5376 NN denotes identification
T1400 5377-5379 IN denotes of
T1401 5380-5387 NNS denotes regions
T1402 5388-5398 VBN denotes associated
T1403 5399-5403 IN denotes with
T1404 5404-5407 DT denotes the
T1405 5431-5440 NN denotes phenotype
T1406 5408-5412 RBR denotes less
T1407 5413-5419 JJ denotes severe
T1408 5420-5430 JJ denotes intestinal
T1409 5440-5441 . denotes .
T1410 5441-5554 sentence denotes Future identification of specific genes should further our understanding of the complex intestinal CF phenotype.
T1411 5442-5448 JJ denotes Future
T1412 5449-5463 NN denotes identification
T1413 5489-5496 VB denotes further
T1414 5464-5466 IN denotes of
T1415 5467-5475 JJ denotes specific
T1416 5476-5481 NNS denotes genes
T1417 5482-5488 MD denotes should
T1418 5497-5500 PRP$ denotes our
T1419 5501-5514 NN denotes understanding
T1420 5515-5517 IN denotes of
T1421 5518-5521 DT denotes the
T1422 5544-5553 NN denotes phenotype
T1423 5522-5529 JJ denotes complex
T1424 5530-5540 JJ denotes intestinal
T1425 5541-5543 NN denotes CF
T1426 5553-5554 . denotes .
T1472 5580-5582 NN denotes CF
T1473 5583-5587 NNS denotes mice
T1474 5612-5616 VBP denotes have
T1475 5588-5590 IN denotes on
T1476 5591-5594 DT denotes the
T1477 5601-5611 NN denotes background
T1478 5595-5600 JJ denotes mixed
T1479 5617-5625 VBN denotes improved
T1480 5638-5642 NN denotes gain
T1481 5626-5630 NN denotes body
T1482 5631-5637 NN denotes weight
T1483 5642-5715 sentence denotes Body mass was recorded for male and female mice at 4 and 8 weeks of age.
T1484 5643-5647 NN denotes Body
T1485 5648-5652 NN denotes mass
T1486 5657-5665 VBN denotes recorded
T1487 5653-5656 VBD denotes was
T1488 5666-5669 IN denotes for
T1489 5670-5674 JJ denotes male
T1490 5686-5690 NNS denotes mice
T1491 5675-5678 CC denotes and
T1492 5679-5685 JJ denotes female
T1493 5691-5693 IN denotes at
T1494 5694-5695 CD denotes 4
T1495 5702-5707 NNS denotes weeks
T1496 5696-5699 CC denotes and
T1497 5700-5701 CD denotes 8
T1498 5708-5710 IN denotes of
T1499 5711-5714 NN denotes age
T1500 5714-5715 . denotes .
T1501 5715-5843 sentence denotes On the B6 background, female and male mice are about 30% smaller than wild type mice at both 4 and 8 weeks of age (Fig. 1A, B).
T1502 5716-5718 IN denotes On
T1503 5759-5762 VBP denotes are
T1504 5719-5722 DT denotes the
T1505 5726-5736 NN denotes background
T1506 5723-5725 NN denotes B6
T1507 5736-5738 , denotes ,
T1508 5738-5744 JJ denotes female
T1509 5754-5758 NNS denotes mice
T1510 5745-5748 CC denotes and
T1511 5749-5753 JJ denotes male
T1512 5763-5768 IN denotes about
T1513 5769-5771 CD denotes 30
T1514 5771-5772 NN denotes %
T1515 5773-5780 JJR denotes smaller
T1516 5781-5785 IN denotes than
T1517 5786-5790 JJ denotes wild
T1518 5791-5795 NN denotes type
T1519 5796-5800 NNS denotes mice
T1520 5801-5803 IN denotes at
T1521 5804-5808 CC denotes both
T1522 5809-5810 CD denotes 4
T1523 5817-5822 NNS denotes weeks
T1524 5811-5814 CC denotes and
T1525 5815-5816 CD denotes 8
T1526 5823-5825 IN denotes of
T1527 5826-5829 NN denotes age
T1528 5830-5831 -LRB- denotes (
T1529 5840-5841 NN denotes B
T1530 5831-5835 NN denotes Fig.
T1531 5836-5838 CD denotes 1A
T1532 5838-5840 , denotes ,
T1533 5841-5842 -RRB- denotes )
T1534 5842-5843 . denotes .
T1535 5843-5977 sentence denotes By comparison, female CF mice on the mixed background were not significantly smaller than wild type mice at 4 weeks of age (Fig. 1A).
T1536 5844-5846 IN denotes By
T1537 5898-5902 VBD denotes were
T1538 5847-5857 NN denotes comparison
T1539 5857-5859 , denotes ,
T1540 5859-5865 JJ denotes female
T1541 5869-5873 NNS denotes mice
T1542 5866-5868 NN denotes CF
T1543 5874-5876 IN denotes on
T1544 5877-5880 DT denotes the
T1545 5887-5897 NN denotes background
T1546 5881-5886 JJ denotes mixed
T1547 5903-5906 RB denotes not
T1548 5907-5920 RB denotes significantly
T1549 5921-5928 JJR denotes smaller
T1550 5929-5933 IN denotes than
T1551 5934-5938 JJ denotes wild
T1552 5939-5943 NN denotes type
T1553 5944-5948 NNS denotes mice
T1554 5949-5951 IN denotes at
T1555 5952-5953 CD denotes 4
T1556 5954-5959 NNS denotes weeks
T1557 5960-5962 IN denotes of
T1558 5963-5966 NN denotes age
T1559 5967-5968 -LRB- denotes (
T1560 5968-5972 NN denotes Fig.
T1561 5973-5975 CD denotes 1A
T1562 5975-5976 -RRB- denotes )
T1563 5976-5977 . denotes .
T1564 5977-6078 sentence denotes The improved body weight of female CF mice on the mixed background was maintained at 8 weeks of age.
T1565 5978-5981 DT denotes The
T1566 5996-6002 NN denotes weight
T1567 5982-5990 VBN denotes improved
T1568 5991-5995 NN denotes body
T1569 6049-6059 VBN denotes maintained
T1570 6003-6005 IN denotes of
T1571 6006-6012 JJ denotes female
T1572 6016-6020 NNS denotes mice
T1573 6013-6015 NN denotes CF
T1574 6021-6023 IN denotes on
T1575 6024-6027 DT denotes the
T1576 6034-6044 NN denotes background
T1577 6028-6033 JJ denotes mixed
T1578 6045-6048 VBD denotes was
T1579 6060-6062 IN denotes at
T1580 6063-6064 CD denotes 8
T1581 6065-6070 NNS denotes weeks
T1582 6071-6073 IN denotes of
T1583 6074-6077 NN denotes age
T1584 6077-6078 . denotes .
T1585 6078-6258 sentence denotes Male CF mice on the mixed background at 4 weeks of age were significantly smaller than wild type and not significantly larger than CF mice congenic on the B6 background (Fig. 1B).
T1586 6079-6083 JJ denotes Male
T1587 6087-6091 NNS denotes mice
T1588 6084-6086 NN denotes CF
T1589 6134-6138 VBD denotes were
T1590 6092-6094 IN denotes on
T1591 6095-6098 DT denotes the
T1592 6105-6115 NN denotes background
T1593 6099-6104 JJ denotes mixed
T1594 6116-6118 IN denotes at
T1595 6119-6120 CD denotes 4
T1596 6121-6126 NNS denotes weeks
T1597 6127-6129 IN denotes of
T1598 6130-6133 NN denotes age
T1599 6139-6152 RB denotes significantly
T1600 6153-6160 JJR denotes smaller
T1601 6161-6165 IN denotes than
T1602 6166-6170 JJ denotes wild
T1603 6171-6175 NN denotes type
T1604 6176-6179 CC denotes and
T1605 6180-6183 RB denotes not
T1606 6184-6197 RB denotes significantly
T1607 6198-6204 JJR denotes larger
T1608 6205-6209 IN denotes than
T1609 6210-6212 NN denotes CF
T1610 6213-6217 NNS denotes mice
T1611 6218-6226 JJ denotes congenic
T1612 6227-6229 IN denotes on
T1613 6230-6233 DT denotes the
T1614 6237-6247 NN denotes background
T1615 6234-6236 NN denotes B6
T1616 6248-6249 -LRB- denotes (
T1617 6249-6253 NN denotes Fig.
T1618 6254-6256 CD denotes 1B
T1619 6256-6257 -RRB- denotes )
T1620 6257-6258 . denotes .
T1621 6258-6406 sentence denotes By 8 weeks of age, CF males on the mixed background were 12% smaller but this was not significantly different compared to wild type mice (Fig. 1B).
T1622 6259-6261 IN denotes By
T1623 6311-6315 VBD denotes were
T1624 6262-6263 CD denotes 8
T1625 6264-6269 NNS denotes weeks
T1626 6270-6272 IN denotes of
T1627 6273-6276 NN denotes age
T1628 6276-6278 , denotes ,
T1629 6278-6280 NN denotes CF
T1630 6281-6286 NNS denotes males
T1631 6287-6289 IN denotes on
T1632 6290-6293 DT denotes the
T1633 6300-6310 NN denotes background
T1634 6294-6299 JJ denotes mixed
T1635 6316-6318 CD denotes 12
T1636 6318-6319 NN denotes %
T1637 6320-6327 JJR denotes smaller
T1638 6328-6331 CC denotes but
T1639 6332-6336 DT denotes this
T1640 6337-6340 VBD denotes was
T1641 6341-6344 RB denotes not
T1642 6345-6358 RB denotes significantly
T1643 6359-6368 JJ denotes different
T1644 6369-6377 VBN denotes compared
T1645 6378-6380 IN denotes to
T1646 6381-6385 JJ denotes wild
T1647 6386-6390 NN denotes type
T1648 6391-6395 NNS denotes mice
T1649 6396-6397 -LRB- denotes (
T1650 6397-6401 NN denotes Fig.
T1651 6402-6404 CD denotes 1B
T1652 6404-6405 -RRB- denotes )
T1653 6405-6406 . denotes .
T1974 6902-6904 NN denotes CF
T1975 6905-6909 NNS denotes mice
T1976 6934-6938 VBP denotes have
T1977 6910-6912 IN denotes on
T1978 6913-6916 DT denotes the
T1979 6923-6933 NN denotes background
T1980 6917-6922 JJ denotes mixed
T1981 6939-6946 VBN denotes reduced
T1982 6947-6957 NN denotes expression
T1983 6958-6960 IN denotes of
T1984 6961-6973 JJ denotes inflammatory
T1985 6974-6981 NNS denotes markers
T1986 6981-7098 sentence denotes Previous work showed that CF mice on the B6 background have an innate-type inflammation of the small intestine [21].
T1987 6982-6990 JJ denotes Previous
T1988 6991-6995 NN denotes work
T1989 6996-7002 VBD denotes showed
T1990 7003-7007 IN denotes that
T1991 7037-7041 VBP denotes have
T1992 7008-7010 NN denotes CF
T1993 7011-7015 NNS denotes mice
T1994 7016-7018 IN denotes on
T1995 7019-7022 DT denotes the
T1996 7026-7036 NN denotes background
T1997 7023-7025 NN denotes B6
T1998 7042-7044 DT denotes an
T1999 7057-7069 NN denotes inflammation
T2000 7045-7051 JJ denotes innate
T2001 7052-7056 NN denotes type
T2002 7051-7052 HYPH denotes -
T2003 7070-7072 IN denotes of
T2004 7073-7076 DT denotes the
T2005 7083-7092 NN denotes intestine
T2006 7077-7082 JJ denotes small
T2007 7093-7094 -LRB- denotes [
T2008 7094-7096 CD denotes 21
T2009 7096-7097 -RRB- denotes ]
T2010 7097-7098 . denotes .
T2011 7098-7266 sentence denotes To determine whether the mixed genetic background affected expression of inflammatory marker genes, quantitative, real-time RT-PCR was used to measure gene expression.
T2012 7099-7101 TO denotes To
T2013 7102-7111 VB denotes determine
T2014 7234-7238 VBN denotes used
T2015 7112-7119 IN denotes whether
T2016 7149-7157 VBD denotes affected
T2017 7120-7123 DT denotes the
T2018 7138-7148 NN denotes background
T2019 7124-7129 JJ denotes mixed
T2020 7130-7137 JJ denotes genetic
T2021 7158-7168 NN denotes expression
T2022 7169-7171 IN denotes of
T2023 7172-7184 JJ denotes inflammatory
T2024 7192-7197 NNS denotes genes
T2025 7185-7191 NN denotes marker
T2026 7197-7199 , denotes ,
T2027 7199-7211 JJ denotes quantitative
T2028 7226-7229 NN denotes PCR
T2029 7211-7213 , denotes ,
T2030 7213-7217 JJ denotes real
T2031 7218-7222 NN denotes time
T2032 7217-7218 HYPH denotes -
T2033 7223-7225 NN denotes RT
T2034 7225-7226 HYPH denotes -
T2035 7230-7233 VBD denotes was
T2036 7239-7241 TO denotes to
T2037 7242-7249 VB denotes measure
T2038 7250-7254 NN denotes gene
T2039 7255-7265 NN denotes expression
T2040 7265-7266 . denotes .
T2041 7266-7376 sentence denotes Expression of the following genes was compared in wild type and CF mice on the different genetic backgrounds.
T2042 7267-7277 NN denotes Expression
T2043 7305-7313 VBN denotes compared
T2044 7278-7280 IN denotes of
T2045 7281-7284 DT denotes the
T2046 7295-7300 NNS denotes genes
T2047 7285-7294 VBG denotes following
T2048 7301-7304 VBD denotes was
T2049 7314-7316 IN denotes in
T2050 7317-7321 JJ denotes wild
T2051 7322-7326 NN denotes type
T2052 7334-7338 NNS denotes mice
T2053 7327-7330 CC denotes and
T2054 7331-7333 NN denotes CF
T2055 7339-7341 IN denotes on
T2056 7342-7345 DT denotes the
T2057 7364-7375 NNS denotes backgrounds
T2058 7346-7355 JJ denotes different
T2059 7356-7363 JJ denotes genetic
T2060 7375-7376 . denotes .
T2061 7376-7514 sentence denotes Mast cell protease 2 (Mcpt2) is a marker of differentiated mast cells [22] and mast cells are more abundant in the B6 CF mouse intestine.
T2062 7377-7381 NN denotes Mast
T2063 7387-7395 NN denotes protease
T2064 7382-7386 NN denotes cell
T2065 7406-7408 VBZ denotes is
T2066 7396-7397 CD denotes 2
T2067 7398-7399 -LRB- denotes (
T2068 7399-7404 NN denotes Mcpt2
T2069 7404-7405 -RRB- denotes )
T2070 7409-7410 DT denotes a
T2071 7411-7417 NN denotes marker
T2072 7418-7420 IN denotes of
T2073 7421-7435 VBN denotes differentiated
T2074 7441-7446 NNS denotes cells
T2075 7436-7440 NN denotes mast
T2076 7447-7448 -LRB- denotes [
T2077 7448-7450 CD denotes 22
T2078 7450-7451 -RRB- denotes ]
T2079 7452-7455 CC denotes and
T2080 7456-7460 NN denotes mast
T2081 7461-7466 NNS denotes cells
T2082 7467-7470 VBP denotes are
T2083 7471-7475 RBR denotes more
T2084 7476-7484 JJ denotes abundant
T2085 7485-7487 IN denotes in
T2086 7488-7491 DT denotes the
T2087 7504-7513 NN denotes intestine
T2088 7492-7494 NN denotes B6
T2089 7495-7497 NN denotes CF
T2090 7498-7503 NN denotes mouse
T2091 7513-7514 . denotes .
T2092 7514-7654 sentence denotes Leucine-rich α2 glycoprotein (Lrg1, [23]) is a marker of differentiating neutrophils, which are more numerous in the B6 CF mouse intestine.
T2093 7515-7522 NN denotes Leucine
T2094 7531-7543 NN denotes glycoprotein
T2095 7522-7523 HYPH denotes -
T2096 7523-7527 JJ denotes rich
T2097 7528-7530 NN denotes α2
T2098 7557-7559 VBZ denotes is
T2099 7544-7545 -LRB- denotes (
T2100 7545-7549 NN denotes Lrg1
T2101 7549-7551 , denotes ,
T2102 7551-7552 -LRB- denotes [
T2103 7552-7554 CD denotes 23
T2104 7554-7555 -RRB- denotes ]
T2105 7555-7556 -RRB- denotes )
T2106 7560-7561 DT denotes a
T2107 7562-7568 NN denotes marker
T2108 7569-7571 IN denotes of
T2109 7572-7587 VBG denotes differentiating
T2110 7588-7599 NNS denotes neutrophils
T2111 7599-7601 , denotes ,
T2112 7601-7606 WDT denotes which
T2113 7607-7610 VBP denotes are
T2114 7611-7615 RBR denotes more
T2115 7616-7624 JJ denotes numerous
T2116 7625-7627 IN denotes in
T2117 7628-7631 DT denotes the
T2118 7644-7653 NN denotes intestine
T2119 7632-7634 NN denotes B6
T2120 7638-7643 NN denotes mouse
T2121 7635-7637 NN denotes CF
T2122 7653-7654 . denotes .
T2123 7654-7868 sentence denotes The same gene is also known as leucine-rich high endothelial cell glycoprotein (Lrhg) and has been shown to be a marker of high endothelial venules (HEV) [24] which increase in tissues during inflammation [25,26].
T2124 7655-7658 DT denotes The
T2125 7664-7668 NN denotes gene
T2126 7659-7663 JJ denotes same
T2127 7677-7682 VBN denotes known
T2128 7669-7671 VBZ denotes is
T2129 7672-7676 RB denotes also
T2130 7683-7685 IN denotes as
T2131 7686-7693 NN denotes leucine
T2132 7694-7698 JJ denotes rich
T2133 7693-7694 HYPH denotes -
T2134 7721-7733 NN denotes glycoprotein
T2135 7699-7703 JJ denotes high
T2136 7704-7715 JJ denotes endothelial
T2137 7716-7720 NN denotes cell
T2138 7734-7735 -LRB- denotes (
T2139 7735-7739 NN denotes Lrhg
T2140 7739-7740 -RRB- denotes )
T2141 7741-7744 CC denotes and
T2142 7745-7748 VBZ denotes has
T2143 7754-7759 VBN denotes shown
T2144 7749-7753 VBN denotes been
T2145 7760-7762 TO denotes to
T2146 7763-7765 VB denotes be
T2147 7766-7767 DT denotes a
T2148 7768-7774 NN denotes marker
T2149 7775-7777 IN denotes of
T2150 7778-7782 JJ denotes high
T2151 7795-7802 NNS denotes venules
T2152 7783-7794 JJ denotes endothelial
T2153 7803-7804 -LRB- denotes (
T2154 7804-7807 NN denotes HEV
T2155 7807-7808 -RRB- denotes )
T2156 7809-7810 -LRB- denotes [
T2157 7810-7812 CD denotes 24
T2158 7812-7813 -RRB- denotes ]
T2159 7814-7819 WDT denotes which
T2160 7820-7828 VBP denotes increase
T2161 7829-7831 IN denotes in
T2162 7832-7839 NNS denotes tissues
T2163 7840-7846 IN denotes during
T2164 7847-7859 NN denotes inflammation
T2165 7860-7861 -LRB- denotes [
T2166 7864-7866 CD denotes 26
T2167 7861-7863 CD denotes 25
T2168 7863-7864 , denotes ,
T2169 7866-7867 -RRB- denotes ]
T2170 7867-7868 . denotes .
T2171 7868-8030 sentence denotes Hematopoietic cell transcript 1 (HemT1, [27]) is a marker of blood cell proliferation and its expression is strongly elevated in the B6 CF mouse small intestine.
T2172 7869-7882 JJ denotes Hematopoietic
T2173 7888-7898 NN denotes transcript
T2174 7883-7887 NN denotes cell
T2175 7915-7917 VBZ denotes is
T2176 7899-7900 CD denotes 1
T2177 7901-7902 -LRB- denotes (
T2178 7902-7907 NN denotes HemT1
T2179 7907-7909 , denotes ,
T2180 7909-7910 -LRB- denotes [
T2181 7910-7912 CD denotes 27
T2182 7912-7913 -RRB- denotes ]
T2183 7913-7914 -RRB- denotes )
T2184 7918-7919 DT denotes a
T2185 7920-7926 NN denotes marker
T2186 7927-7929 IN denotes of
T2187 7930-7935 NN denotes blood
T2188 7941-7954 NN denotes proliferation
T2189 7936-7940 NN denotes cell
T2190 7955-7958 CC denotes and
T2191 7959-7962 PRP$ denotes its
T2192 7963-7973 NN denotes expression
T2193 7974-7976 VBZ denotes is
T2194 7977-7985 RB denotes strongly
T2195 7986-7994 JJ denotes elevated
T2196 7995-7997 IN denotes in
T2197 7998-8001 DT denotes the
T2198 8020-8029 NN denotes intestine
T2199 8002-8004 NN denotes B6
T2200 8008-8013 NN denotes mouse
T2201 8005-8007 NN denotes CF
T2202 8014-8019 JJ denotes small
T2203 8029-8030 . denotes .
T2204 8030-8166 sentence denotes Serum amyloid A3 (SAA3, [28]) is an acute phase gene and its expression in villus epithelial cells is increased in the B6 CF intestine.
T2205 8031-8036 NN denotes Serum
T2206 8045-8047 NN denotes A3
T2207 8037-8044 NN denotes amyloid
T2208 8061-8063 VBZ denotes is
T2209 8048-8049 -LRB- denotes (
T2210 8049-8053 NN denotes SAA3
T2211 8053-8055 , denotes ,
T2212 8055-8056 -LRB- denotes [
T2213 8056-8058 CD denotes 28
T2214 8058-8059 -RRB- denotes ]
T2215 8059-8060 -RRB- denotes )
T2216 8064-8066 DT denotes an
T2217 8079-8083 NN denotes gene
T2218 8067-8072 JJ denotes acute
T2219 8073-8078 NN denotes phase
T2220 8084-8087 CC denotes and
T2221 8088-8091 PRP$ denotes its
T2222 8092-8102 NN denotes expression
T2223 8130-8132 VBZ denotes is
T2224 8103-8105 IN denotes in
T2225 8106-8112 NN denotes villus
T2226 8124-8129 NNS denotes cells
T2227 8113-8123 JJ denotes epithelial
T2228 8133-8142 JJ denotes increased
T2229 8143-8145 IN denotes in
T2230 8146-8149 DT denotes the
T2231 8156-8165 NN denotes intestine
T2232 8150-8152 NN denotes B6
T2233 8153-8155 NN denotes CF
T2234 8165-8166 . denotes .
T2235 8166-8341 sentence denotes Suppressor of cytokine signaling 3 (SOCS3, [29]) is an anti-inflammatory gene that interacts with the JAK-STAT pathway and its expression in increased in the B6 CF intestine.
T2236 8167-8177 NN denotes Suppressor
T2237 8216-8218 VBZ denotes is
T2238 8178-8180 IN denotes of
T2239 8181-8189 NN denotes cytokine
T2240 8190-8199 NN denotes signaling
T2241 8200-8201 CD denotes 3
T2242 8202-8203 -LRB- denotes (
T2243 8203-8208 NN denotes SOCS3
T2244 8208-8210 , denotes ,
T2245 8210-8211 -LRB- denotes [
T2246 8211-8213 CD denotes 29
T2247 8213-8214 -RRB- denotes ]
T2248 8214-8215 -RRB- denotes )
T2249 8219-8221 DT denotes an
T2250 8240-8244 NN denotes gene
T2251 8222-8239 JJ denotes anti-inflammatory
T2252 8245-8249 WDT denotes that
T2253 8250-8259 VBZ denotes interacts
T2254 8260-8264 IN denotes with
T2255 8265-8268 DT denotes the
T2256 8278-8285 NN denotes pathway
T2257 8269-8272 NN denotes JAK
T2258 8273-8277 NN denotes STAT
T2259 8272-8273 HYPH denotes -
T2260 8286-8289 CC denotes and
T2261 8290-8293 PRP$ denotes its
T2262 8294-8304 NN denotes expression
T2263 8305-8307 VBZ denotes in
T2264 8308-8317 JJ denotes increased
T2265 8318-8320 IN denotes in
T2266 8321-8324 DT denotes the
T2267 8331-8340 NN denotes intestine
T2268 8325-8327 NN denotes B6
T2269 8328-8330 NN denotes CF
T2270 8340-8341 . denotes .
T2271 8341-8520 sentence denotes Muclin (also known as dmbt1, [30]) expression is upregulated in the B6 CF intestine; it is a cell surface glycoprotein postulated to be an epithelial protective molecule [21,31].
T2272 8342-8348 NN denotes Muclin
T2273 8377-8387 NN denotes expression
T2274 8349-8350 -LRB- denotes (
T2275 8355-8360 VBN denotes known
T2276 8350-8354 RB denotes also
T2277 8361-8363 IN denotes as
T2278 8364-8369 NN denotes dmbt1
T2279 8369-8371 , denotes ,
T2280 8371-8372 -LRB- denotes [
T2281 8372-8374 CD denotes 30
T2282 8374-8375 -RRB- denotes ]
T2283 8375-8376 -RRB- denotes )
T2284 8391-8402 VBN denotes upregulated
T2285 8388-8390 VBZ denotes is
T2286 8430-8432 VBZ denotes is
T2287 8403-8405 IN denotes in
T2288 8406-8409 DT denotes the
T2289 8416-8425 NN denotes intestine
T2290 8410-8412 NN denotes B6
T2291 8413-8415 NN denotes CF
T2292 8425-8426 : denotes ;
T2293 8427-8429 PRP denotes it
T2294 8433-8434 DT denotes a
T2295 8448-8460 NN denotes glycoprotein
T2296 8435-8439 NN denotes cell
T2297 8440-8447 NN denotes surface
T2298 8461-8471 VBN denotes postulated
T2299 8472-8474 TO denotes to
T2300 8475-8477 VB denotes be
T2301 8478-8480 DT denotes an
T2302 8503-8511 NN denotes molecule
T2303 8481-8491 JJ denotes epithelial
T2304 8492-8502 JJ denotes protective
T2305 8512-8513 -LRB- denotes [
T2306 8516-8518 CD denotes 31
T2307 8513-8515 CD denotes 21
T2308 8515-8516 , denotes ,
T2309 8518-8519 -RRB- denotes ]
T2310 8519-8520 . denotes .
T2311 8520-8654 sentence denotes Consistent with previous results, Mcpt2 was increased in CF mice on the B6 background by over 9-fold compared to wild type (Fig. 2A).
T2312 8521-8531 JJ denotes Consistent
T2313 8565-8574 VBN denotes increased
T2314 8532-8536 IN denotes with
T2315 8537-8545 JJ denotes previous
T2316 8546-8553 NNS denotes results
T2317 8553-8555 , denotes ,
T2318 8555-8560 NN denotes Mcpt2
T2319 8561-8564 VBD denotes was
T2320 8575-8577 IN denotes in
T2321 8578-8580 NN denotes CF
T2322 8581-8585 NNS denotes mice
T2323 8586-8588 IN denotes on
T2324 8589-8592 DT denotes the
T2325 8596-8606 NN denotes background
T2326 8593-8595 NN denotes B6
T2327 8607-8609 IN denotes by
T2328 8610-8614 IN denotes over
T2329 8615-8621 RB denotes 9-fold
T2330 8622-8630 VBN denotes compared
T2331 8631-8633 IN denotes to
T2332 8634-8638 JJ denotes wild
T2333 8639-8643 NN denotes type
T2334 8644-8645 -LRB- denotes (
T2335 8645-8649 NN denotes Fig.
T2336 8650-8652 CD denotes 2A
T2337 8652-8653 -RRB- denotes )
T2338 8653-8654 . denotes .
T2339 8654-8786 sentence denotes By contrast, there was not a significant difference in Mcpt2 expression between CF and wild type on the mixed background (Fig. 2A).
T2340 8655-8657 IN denotes By
T2341 8674-8677 VBD denotes was
T2342 8658-8666 NN denotes contrast
T2343 8666-8668 , denotes ,
T2344 8668-8673 EX denotes there
T2345 8678-8681 RB denotes not
T2346 8682-8683 DT denotes a
T2347 8696-8706 NN denotes difference
T2348 8684-8695 JJ denotes significant
T2349 8707-8709 IN denotes in
T2350 8710-8715 NN denotes Mcpt2
T2351 8716-8726 NN denotes expression
T2352 8727-8734 IN denotes between
T2353 8735-8737 NN denotes CF
T2354 8738-8741 CC denotes and
T2355 8742-8746 JJ denotes wild
T2356 8747-8751 NN denotes type
T2357 8752-8754 IN denotes on
T2358 8755-8758 DT denotes the
T2359 8765-8775 NN denotes background
T2360 8759-8764 JJ denotes mixed
T2361 8776-8777 -LRB- denotes (
T2362 8777-8781 NN denotes Fig.
T2363 8782-8784 CD denotes 2A
T2364 8784-8785 -RRB- denotes )
T2365 8785-8786 . denotes .
T2366 8786-8994 sentence denotes Lrg1/Lrhg expression was increased more than 20-fold in CF mice on the B6 background compared to wild type, but there was no significant difference between CF and wild type on the mixed background (Fig. 2B).
T2367 8787-8791 NN denotes Lrg1
T2368 8792-8796 NN denotes Lrhg
T2369 8791-8792 HYPH denotes /
T2370 8797-8807 NN denotes expression
T2371 8812-8821 VBN denotes increased
T2372 8808-8811 VBD denotes was
T2373 8822-8826 RBR denotes more
T2374 8832-8839 RB denotes 20-fold
T2375 8827-8831 IN denotes than
T2376 8840-8842 IN denotes in
T2377 8843-8845 NN denotes CF
T2378 8846-8850 NNS denotes mice
T2379 8851-8853 IN denotes on
T2380 8854-8857 DT denotes the
T2381 8861-8871 NN denotes background
T2382 8858-8860 NN denotes B6
T2383 8872-8880 VBN denotes compared
T2384 8881-8883 IN denotes to
T2385 8884-8888 JJ denotes wild
T2386 8889-8893 NN denotes type
T2387 8893-8895 , denotes ,
T2388 8895-8898 CC denotes but
T2389 8899-8904 EX denotes there
T2390 8905-8908 VBD denotes was
T2391 8909-8911 DT denotes no
T2392 8924-8934 NN denotes difference
T2393 8912-8923 JJ denotes significant
T2394 8935-8942 IN denotes between
T2395 8943-8945 NN denotes CF
T2396 8946-8949 CC denotes and
T2397 8950-8954 JJ denotes wild
T2398 8955-8959 NN denotes type
T2399 8960-8962 IN denotes on
T2400 8963-8966 DT denotes the
T2401 8973-8983 NN denotes background
T2402 8967-8972 JJ denotes mixed
T2403 8984-8985 -LRB- denotes (
T2404 8985-8989 NN denotes Fig.
T2405 8990-8992 CD denotes 2B
T2406 8992-8993 -RRB- denotes )
T2407 8993-8994 . denotes .
T2408 8994-9159 sentence denotes SAA3 mRNA was about 3.5-fold increased in CF mice on the B6 background, but was not significantly different compared to wild type on the mixed background (Fig. 2C).
T2409 8995-8999 NN denotes SAA3
T2410 9000-9004 NN denotes mRNA
T2411 9005-9008 VBD denotes was
T2412 9009-9014 IN denotes about
T2413 9015-9023 RB denotes 3.5-fold
T2414 9024-9033 JJ denotes increased
T2415 9034-9036 IN denotes in
T2416 9037-9039 NN denotes CF
T2417 9040-9044 NNS denotes mice
T2418 9045-9047 IN denotes on
T2419 9048-9051 DT denotes the
T2420 9055-9065 NN denotes background
T2421 9052-9054 NN denotes B6
T2422 9065-9067 , denotes ,
T2423 9067-9070 CC denotes but
T2424 9071-9074 VBD denotes was
T2425 9075-9078 RB denotes not
T2426 9079-9092 RB denotes significantly
T2427 9093-9102 JJ denotes different
T2428 9103-9111 VBN denotes compared
T2429 9112-9114 IN denotes to
T2430 9115-9119 JJ denotes wild
T2431 9120-9124 NN denotes type
T2432 9125-9127 IN denotes on
T2433 9128-9131 DT denotes the
T2434 9138-9148 NN denotes background
T2435 9132-9137 JJ denotes mixed
T2436 9149-9150 -LRB- denotes (
T2437 9150-9154 NN denotes Fig.
T2438 9155-9157 CD denotes 2C
T2439 9157-9158 -RRB- denotes )
T2440 9158-9159 . denotes .
T2441 9159-9371 sentence denotes SOCS3 was more than 2-fold increased in CF mice on the B6 background compared to wild type, and on the mixed background was only 1.5-fold greater than wild type, and the difference was not significant (Fig. 2D).
T2442 9160-9165 NN denotes SOCS3
T2443 9166-9169 VBD denotes was
T2444 9170-9174 JJR denotes more
T2445 9180-9186 RB denotes 2-fold
T2446 9175-9179 IN denotes than
T2447 9187-9196 JJ denotes increased
T2448 9197-9199 IN denotes in
T2449 9200-9202 NN denotes CF
T2450 9203-9207 NNS denotes mice
T2451 9208-9210 IN denotes on
T2452 9211-9214 DT denotes the
T2453 9218-9228 NN denotes background
T2454 9215-9217 NN denotes B6
T2455 9229-9237 VBN denotes compared
T2456 9238-9240 IN denotes to
T2457 9241-9245 JJ denotes wild
T2458 9246-9250 NN denotes type
T2459 9250-9252 , denotes ,
T2460 9252-9255 CC denotes and
T2461 9256-9258 IN denotes on
T2462 9280-9283 VBD denotes was
T2463 9259-9262 DT denotes the
T2464 9269-9279 NN denotes background
T2465 9263-9268 JJ denotes mixed
T2466 9284-9288 RB denotes only
T2467 9289-9297 RB denotes 1.5-fold
T2468 9298-9305 JJR denotes greater
T2469 9306-9310 IN denotes than
T2470 9311-9315 JJ denotes wild
T2471 9316-9320 NN denotes type
T2472 9320-9322 , denotes ,
T2473 9322-9325 CC denotes and
T2474 9326-9329 DT denotes the
T2475 9330-9340 NN denotes difference
T2476 9341-9344 VBD denotes was
T2477 9345-9348 RB denotes not
T2478 9349-9360 JJ denotes significant
T2479 9361-9362 -LRB- denotes (
T2480 9362-9366 NN denotes Fig.
T2481 9367-9369 CD denotes 2D
T2482 9369-9370 -RRB- denotes )
T2483 9370-9371 . denotes .
T2484 9371-9569 sentence denotes Muclin is overexpressed almost 3-fold in the CF intestine on the B6 background, but on the mixed background the expression level in CF mice was not significantly different than wild type (Fig. 2E).
T2485 9372-9378 NN denotes Muclin
T2486 9382-9395 VBN denotes overexpressed
T2487 9379-9381 VBZ denotes is
T2488 9396-9402 RB denotes almost
T2489 9403-9409 RB denotes 3-fold
T2490 9410-9412 IN denotes in
T2491 9413-9416 DT denotes the
T2492 9420-9429 NN denotes intestine
T2493 9417-9419 NN denotes CF
T2494 9430-9432 IN denotes on
T2495 9433-9436 DT denotes the
T2496 9440-9450 NN denotes background
T2497 9437-9439 NN denotes B6
T2498 9450-9452 , denotes ,
T2542 9662-9665 DT denotes the
T2543 9672-9682 NN denotes background
T2544 9666-9671 JJ denotes mixed
T2545 9683-9686 DT denotes the
T2546 9701-9706 NN denotes level
T2547 9687-9689 NN denotes CF
T2548 9690-9700 NN denotes expression
T2549 9711-9714 RB denotes not
T2550 9715-9728 RB denotes statistically
T2551 9729-9738 JJ denotes different
T2552 9739-9743 IN denotes from
T2553 9744-9748 JJ denotes wild
T2554 9749-9753 NN denotes type
T2555 9754-9755 -LRB- denotes (
T2556 9755-9759 NN denotes Fig.
T2557 9760-9762 CD denotes 2F
T2558 9762-9763 -RRB- denotes )
T2559 9763-9764 . denotes .
T2560 9764-10655 sentence denotes Figure 2 Effect of genetic background on inflammatory gene expression in CF mouse small intestine. RNA expression levels were determined by quantitative real-time RT-PCR using gene-specific primers. Data are expressed relative to GAPDH mRNA, which does not vary between wild type and CF mice. Data are means ± SEM. (*) CF vs wild type on the B6 background, P < 0.005; (+) CF on the mixed background vs CF on the B6 background, P < 0.05 by ANOVA with a post-hoc Tukey's test. There were no significant differences for any of the 6 genes comparing: wild type B6 mice vs wild type mixed background; or CF mice on the mixed background vs wild type on either background. There were 8–11 samples analyzed per group for each gene. Because of the gender differences in body weight, the gene expression data were analyzed by gender but there was no significant difference between females and males.
T2561 10490-10497 IN denotes Because
T2562 10570-10578 VBN denotes analyzed
T2563 10498-10500 IN denotes of
T2564 10501-10504 DT denotes the
T2565 10512-10523 NNS denotes differences
T2566 10505-10511 NN denotes gender
T2567 10524-10526 IN denotes in
T2568 10527-10531 NN denotes body
T2569 10532-10538 NN denotes weight
T2570 10538-10540 , denotes ,
T2571 10540-10543 DT denotes the
T2572 10560-10564 NNS denotes data
T2573 10544-10548 NN denotes gene
T2574 10549-10559 NN denotes expression
T2575 10565-10569 VBD denotes were
T2576 10579-10581 IN denotes by
T2577 10582-10588 NN denotes gender
T2578 10589-10592 CC denotes but
T2579 10593-10598 EX denotes there
T2580 10599-10602 VBD denotes was
T2581 10603-10605 DT denotes no
T2582 10618-10628 NN denotes difference
T2583 10606-10617 JJ denotes significant
T2584 10629-10636 IN denotes between
T2585 10637-10644 NNS denotes females
T2586 10645-10648 CC denotes and
T2587 10649-10654 NNS denotes males
T2588 10654-10655 . denotes .
T2589 10655-10734 sentence denotes With the limited number of animals, there was also no evidence for imprinting.
T2590 10656-10660 IN denotes With
T2591 10698-10701 VBD denotes was
T2592 10661-10664 DT denotes the
T2593 10673-10679 NN denotes number
T2594 10665-10672 JJ denotes limited
T2595 10680-10682 IN denotes of
T2596 10683-10690 NNS denotes animals
T2597 10690-10692 , denotes ,
T2598 10692-10697 EX denotes there
T2599 10702-10706 RB denotes also
T2600 10707-10709 DT denotes no
T2601 10710-10718 NN denotes evidence
T2602 10719-10722 IN denotes for
T2603 10723-10733 NN denotes imprinting
T2604 10733-10734 . denotes .
T2802 10736-10738 NN denotes CF
T2803 10739-10743 NNS denotes mice
T2804 10768-10772 VBP denotes have
T2805 10744-10746 IN denotes on
T2806 10747-10750 DT denotes the
T2807 10757-10767 NN denotes background
T2808 10751-10756 JJ denotes mixed
T2809 10773-10777 RBR denotes less
T2810 10795-10807 NN denotes accumulation
T2811 10778-10788 JJ denotes intestinal
T2812 10789-10794 NN denotes mucus
T2813 10807-11051 sentence denotes The most striking histological difference in the CF mouse small intestine is the accumulation of mucus in intestinal crypts which is associated with the lethal obstruction that results in death of these mice on a standard solid chow diet [32].
T2814 10808-10811 DT denotes The
T2815 10839-10849 NN denotes difference
T2816 10812-10816 RBS denotes most
T2817 10817-10825 JJ denotes striking
T2818 10826-10838 JJ denotes histological
T2819 10882-10884 VBZ denotes is
T2820 10850-10852 IN denotes in
T2821 10853-10856 DT denotes the
T2822 10872-10881 NN denotes intestine
T2823 10857-10859 NN denotes CF
T2824 10860-10865 NN denotes mouse
T2825 10866-10871 JJ denotes small
T2826 10885-10888 DT denotes the
T2827 10889-10901 NN denotes accumulation
T2828 10902-10904 IN denotes of
T2829 10905-10910 NN denotes mucus
T2830 10911-10913 IN denotes in
T2831 10914-10924 JJ denotes intestinal
T2832 10925-10931 NNS denotes crypts
T2833 10932-10937 WDT denotes which
T2834 10941-10951 VBN denotes associated
T2835 10938-10940 VBZ denotes is
T2836 10952-10956 IN denotes with
T2837 10957-10960 DT denotes the
T2838 10968-10979 NN denotes obstruction
T2839 10961-10967 JJ denotes lethal
T2840 10980-10984 WDT denotes that
T2841 10985-10992 VBZ denotes results
T2842 10993-10995 IN denotes in
T2843 10996-11001 NN denotes death
T2844 11002-11004 IN denotes of
T2845 11005-11010 DT denotes these
T2846 11011-11015 NNS denotes mice
T2847 11016-11018 IN denotes on
T2848 11019-11020 DT denotes a
T2849 11041-11045 NN denotes diet
T2850 11021-11029 JJ denotes standard
T2851 11030-11035 JJ denotes solid
T2852 11036-11040 NN denotes chow
T2853 11046-11047 -LRB- denotes [
T2854 11047-11049 CD denotes 32
T2855 11049-11050 -RRB- denotes ]
T2856 11050-11051 . denotes .
T2857 11051-11173 sentence denotes Using periodic acid Schiff's staining for neutral mucins, histological analysis of small intestine tissues was performed.
T2858 11052-11057 VBG denotes Using
T2859 11163-11172 VBN denotes performed
T2860 11058-11066 JJ denotes periodic
T2861 11067-11071 NN denotes acid
T2862 11081-11089 NN denotes staining
T2863 11072-11078 NNP denotes Schiff
T2864 11078-11080 POS denotes 's
T2865 11090-11093 IN denotes for
T2866 11094-11101 JJ denotes neutral
T2867 11102-11108 NNS denotes mucins
T2868 11108-11110 , denotes ,
T2869 11110-11122 JJ denotes histological
T2870 11123-11131 NN denotes analysis
T2871 11132-11134 IN denotes of
T2872 11135-11140 JJ denotes small
T2873 11151-11158 NNS denotes tissues
T2874 11141-11150 NN denotes intestine
T2875 11159-11162 VBD denotes was
T2876 11172-11173 . denotes .
T2877 11173-11266 sentence denotes The wild type small intestine on both the B6 and the mixed genetic backgrounds were similar.
T2878 11174-11177 DT denotes The
T2879 11194-11203 NN denotes intestine
T2880 11178-11182 JJ denotes wild
T2881 11183-11187 NN denotes type
T2882 11188-11193 JJ denotes small
T2883 11253-11257 VBD denotes were
T2884 11204-11206 IN denotes on
T2885 11207-11211 CC denotes both
T2886 11216-11218 NN denotes B6
T2887 11212-11215 DT denotes the
T2888 11219-11222 CC denotes and
T2889 11223-11226 DT denotes the
T2890 11227-11232 JJ denotes mixed
T2891 11241-11252 NNS denotes backgrounds
T2892 11233-11240 JJ denotes genetic
T2893 11258-11265 JJ denotes similar
T2894 11265-11266 . denotes .
T2895 11266-11384 sentence denotes The intestinal crypts were very small with only traces of PAS-reactivity in the lumen (Fig. 3A and 3C, respectively).
T2896 11267-11270 DT denotes The
T2897 11282-11288 NNS denotes crypts
T2898 11271-11281 JJ denotes intestinal
T2899 11289-11293 VBD denotes were
T2900 11294-11298 RB denotes very
T2901 11299-11304 JJ denotes small
T2902 11305-11309 IN denotes with
T2903 11310-11314 JJ denotes only
T2904 11315-11321 NNS denotes traces
T2905 11322-11324 IN denotes of
T2906 11325-11328 NN denotes PAS
T2907 11329-11339 NN denotes reactivity
T2908 11328-11329 HYPH denotes -
T2909 11340-11342 IN denotes in
T2910 11343-11346 DT denotes the
T2911 11347-11352 NN denotes lumen
T2912 11353-11354 -LRB- denotes (
T2913 11359-11361 CD denotes 3A
T2914 11354-11358 NN denotes Fig.
T2915 11362-11365 CC denotes and
T2916 11366-11368 CD denotes 3C
T2917 11368-11370 , denotes ,
T2918 11370-11382 RB denotes respectively
T2919 11382-11383 -RRB- denotes )
T2920 11383-11384 . denotes .
T2921 11384-11511 sentence denotes The surfaces of the villus epithelium were moderately stained and goblet cells were strongly stained in the wild type tissues.
T2922 11385-11388 DT denotes The
T2923 11389-11397 NNS denotes surfaces
T2924 11423-11427 VBD denotes were
T2925 11398-11400 IN denotes of
T2926 11401-11404 DT denotes the
T2927 11412-11422 NN denotes epithelium
T2928 11405-11411 NN denotes villus
T2929 11428-11438 RB denotes moderately
T2930 11439-11446 JJ denotes stained
T2931 11447-11450 CC denotes and
T2932 11451-11457 NN denotes goblet
T2933 11458-11463 NNS denotes cells
T2934 11478-11485 VBN denotes stained
T2935 11464-11468 VBD denotes were
T2936 11469-11477 RB denotes strongly
T2937 11486-11488 IN denotes in
T2938 11489-11492 DT denotes the
T2939 11503-11510 NNS denotes tissues
T2940 11493-11497 JJ denotes wild
T2941 11498-11502 NN denotes type
T2942 11510-11511 . denotes .
T2943 11511-11653 sentence denotes In contrast, the intestine of CF mice on the B6 genetic background exhibited greatly dilated crypts filled with PAS-reactive mucus (Fig. 3B).
T2944 11512-11514 IN denotes In
T2945 11579-11588 VBD denotes exhibited
T2946 11515-11523 NN denotes contrast
T2947 11523-11525 , denotes ,
T2948 11525-11528 DT denotes the
T2949 11529-11538 NN denotes intestine
T2950 11539-11541 IN denotes of
T2951 11542-11544 NN denotes CF
T2952 11545-11549 NNS denotes mice
T2953 11550-11552 IN denotes on
T2954 11553-11556 DT denotes the
T2955 11568-11578 NN denotes background
T2956 11557-11559 NN denotes B6
T2957 11560-11567 JJ denotes genetic
T2958 11589-11596 RB denotes greatly
T2959 11597-11604 VBN denotes dilated
T2960 11605-11611 NNS denotes crypts
T2961 11612-11618 VBN denotes filled
T2962 11619-11623 IN denotes with
T2963 11624-11627 NN denotes PAS
T2964 11628-11636 JJ denotes reactive
T2965 11627-11628 HYPH denotes -
T2966 11637-11642 NN denotes mucus
T2967 11643-11644 -LRB- denotes (
T2968 11644-11648 NN denotes Fig.
T2969 11649-11651 CD denotes 3B
T2970 11651-11652 -RRB- denotes )
T2971 11652-11653 . denotes .
T2972 11653-11760 sentence denotes CF mice on the mixed background had less mucus accumulation than CF mice on the B6 background (Fig. 3D-F).
T2973 11654-11656 NN denotes CF
T2974 11657-11661 NNS denotes mice
T2975 11686-11689 VBD denotes had
T2976 11662-11664 IN denotes on
T2977 11665-11668 DT denotes the
T2978 11675-11685 NN denotes background
T2979 11669-11674 JJ denotes mixed
T2980 11690-11694 JJ denotes less
T2981 11701-11713 NN denotes accumulation
T2982 11695-11700 NN denotes mucus
T2983 11714-11718 IN denotes than
T2984 11719-11721 NN denotes CF
T2985 11722-11726 NNS denotes mice
T2986 11727-11729 IN denotes on
T2987 11730-11733 DT denotes the
T2988 11737-11747 NN denotes background
T2989 11734-11736 NN denotes B6
T2990 11748-11749 -LRB- denotes (
T2991 11749-11753 NN denotes Fig.
T2992 11754-11756 CD denotes 3D
T2993 11756-11757 SYM denotes -
T2994 11757-11758 NN denotes F
T2995 11758-11759 -RRB- denotes )
T2996 11759-11760 . denotes .
T2997 11760-11849 sentence denotes The amount of mucus in CF mice on the mixed background was variable from mouse to mouse.
T2998 11761-11764 DT denotes The
T2999 11765-11771 NN denotes amount
T3000 11816-11819 VBD denotes was
T3001 11772-11774 IN denotes of
T3002 11775-11780 NN denotes mucus
T3003 11781-11783 IN denotes in
T3004 11784-11786 NN denotes CF
T3005 11787-11791 NNS denotes mice
T3006 11792-11794 IN denotes on
T3007 11795-11798 DT denotes the
T3008 11805-11815 NN denotes background
T3009 11799-11804 JJ denotes mixed
T3010 11820-11828 JJ denotes variable
T3011 11829-11833 IN denotes from
T3012 11834-11839 NN denotes mouse
T3013 11840-11842 IN denotes to
T3014 11843-11848 NN denotes mouse
T3015 11848-11849 . denotes .
T3016 11849-11962 sentence denotes In some mice (Fig. 3D), only occasional crypts had accumulated mucus and the crypt lumina were not very dilated.
T3017 11850-11852 IN denotes In
T3018 11901-11912 VBN denotes accumulated
T3019 11853-11857 DT denotes some
T3020 11858-11862 NNS denotes mice
T3021 11863-11864 -LRB- denotes (
T3022 11864-11868 NN denotes Fig.
T3023 11869-11871 CD denotes 3D
T3024 11871-11872 -RRB- denotes )
T3025 11872-11874 , denotes ,
T3026 11874-11878 RB denotes only
T3027 11890-11896 NNS denotes crypts
T3028 11879-11889 JJ denotes occasional
T3029 11897-11900 VBD denotes had
T3030 11913-11918 NN denotes mucus
T3031 11919-11922 CC denotes and
T3032 11923-11926 DT denotes the
T3033 11933-11939 NNS denotes lumina
T3034 11927-11932 NN denotes crypt
T3035 11940-11944 VBD denotes were
T3036 11945-11948 RB denotes not
T3037 11949-11953 RB denotes very
T3038 11954-11961 JJ denotes dilated
T3039 11961-11962 . denotes .
T3040 11962-12077 sentence denotes In some mice there was more mucus in the crypts (Fig. 3E), while others had moderate mucus accumulation (Fig. 3F).
T3041 11963-11965 IN denotes In
T3042 11982-11985 VBD denotes was
T3043 11966-11970 DT denotes some
T3044 11971-11975 NNS denotes mice
T3045 11976-11981 EX denotes there
T3046 11986-11990 JJR denotes more
T3047 11991-11996 NN denotes mucus
T3048 11997-11999 IN denotes in
T3072 12089-12092 CD denotes six
T3073 12096-12100 NNS denotes mice
T3074 12093-12095 NN denotes CF
T3075 12101-12103 IN denotes on
T3076 12104-12107 DT denotes the
T3077 12114-12124 NN denotes background
T3078 12108-12113 JJ denotes mixed
T3079 12125-12129 VBD denotes were
T3080 12139-12153 RB denotes histologically
T3081 12153-12155 , denotes ,
T3082 12155-12158 CC denotes and
T3083 12159-12164 CD denotes three
T3084 12165-12168 VBD denotes had
T3085 12169-12175 JJ denotes little
T3086 12176-12181 NN denotes mucus
T3087 12181-12183 , denotes ,
T3088 12183-12186 CD denotes one
T3089 12187-12190 VBD denotes had
T3090 12191-12195 DT denotes some
T3091 12196-12201 NN denotes mucus
T3092 12201-12203 , denotes ,
T3093 12203-12206 CC denotes and
T3094 12207-12210 CD denotes two
T3095 12211-12214 VBD denotes had
T3096 12215-12223 JJ denotes moderate
T3097 12224-12231 NNS denotes amounts
T3098 12232-12234 IN denotes of
T3099 12235-12240 NN denotes mucus
T3100 12240-12241 . denotes .
T3101 12241-12400 sentence denotes Despite the variability, all the CF mice on the mixed background had less crypt dilation and less mucus accumulation compared to CF mice on the B6 background.
T3102 12242-12249 IN denotes Despite
T3103 12307-12310 VBD denotes had
T3104 12250-12253 DT denotes the
T3105 12254-12265 NN denotes variability
T3106 12265-12267 , denotes ,
T3107 12267-12270 PDT denotes all
T3108 12278-12282 NNS denotes mice
T3109 12271-12274 DT denotes the
T3110 12275-12277 NN denotes CF
T3111 12283-12285 IN denotes on
T3112 12286-12289 DT denotes the
T3113 12296-12306 NN denotes background
T3114 12290-12295 JJ denotes mixed
T3115 12311-12315 JJ denotes less
T3116 12322-12330 NN denotes dilation
T3117 12316-12321 NN denotes crypt
T3118 12331-12334 CC denotes and
T3119 12335-12339 JJ denotes less
T3120 12346-12358 NN denotes accumulation
T3121 12340-12345 NN denotes mucus
T3122 12359-12367 VBN denotes compared
T3123 12368-12370 IN denotes to
T3124 12371-12373 NN denotes CF
T3125 12374-12378 NNS denotes mice
T3126 12379-12381 IN denotes on
T3127 12382-12385 DT denotes the
T3128 12389-12399 NN denotes background
T3129 12386-12388 NN denotes B6
T3130 12399-12400 . denotes .
T3133 13432-13439 VBZ denotes appears
T3134 13427-13429 , denotes ,
T3135 13429-13431 PRP denotes it
T3136 13440-13444 IN denotes that
T3137 13533-13539 VBP denotes affect
T3138 13445-13453 WDT denotes whatever
T3139 13458-13464 NN denotes nature
T3140 13454-13457 DT denotes the
T3141 13465-13467 IN denotes of
T3142 13468-13471 DT denotes the
T3143 13480-13491 NNS denotes differences
T3144 13472-13479 JJ denotes genetic
T3145 13492-13499 IN denotes between
T3146 13500-13503 DT denotes the
T3147 13519-13526 NNS denotes strains
T3148 13504-13507 CD denotes two
T3149 13508-13518 NN denotes background
T3150 13526-13528 , denotes ,
T3151 13528-13532 PRP denotes they
T3152 13540-13549 NN denotes secretion
T3153 13550-13553 CC denotes and
T3154 13554-13566 NN denotes accumulation
T3155 13567-13569 IN denotes of
T3156 13570-13575 NN denotes mucus
T3157 13576-13578 IN denotes in
T3158 13579-13582 DT denotes the
T3159 13592-13601 NN denotes intestine
T3160 13583-13585 NN denotes CF
T3161 13586-13591 JJ denotes small
T3162 13601-13602 . denotes .
T3163 13602-13794 sentence denotes To determine if the difference could be accounted for by altered mucin gene expression, quantitative RT-PCR was used to measure mRNA expression of the intestinal goblet cell mucin gene, Muc2.
T3164 13603-13605 TO denotes To
T3165 13606-13615 VB denotes determine
T3166 13715-13719 VBN denotes used
T3167 13616-13618 IN denotes if
T3168 13643-13652 VBN denotes accounted
T3169 13619-13622 DT denotes the
T3170 13623-13633 NN denotes difference
T3171 13634-13639 MD denotes could
T3172 13640-13642 VB denotes be
T3173 13653-13656 IN denotes for
T3174 13657-13659 IN denotes by
T3175 13660-13667 JJ denotes altered
T3176 13674-13678 NN denotes gene
T3177 13668-13673 NN denotes mucin
T3178 13679-13689 NN denotes expression
T3179 13689-13691 , denotes ,
T3180 13691-13703 JJ denotes quantitative
T3181 13707-13710 NN denotes PCR
T3182 13704-13706 NN denotes RT
T3183 13706-13707 HYPH denotes -
T3184 13711-13714 VBD denotes was
T3185 13720-13722 TO denotes to
T3186 13723-13730 VB denotes measure
T3187 13731-13735 NN denotes mRNA
T3188 13736-13746 NN denotes expression
T3189 13747-13749 IN denotes of
T3190 13750-13753 DT denotes the
T3191 13783-13787 NN denotes gene
T3192 13754-13764 JJ denotes intestinal
T3193 13772-13776 NN denotes cell
T3194 13765-13771 NN denotes goblet
T3195 13777-13782 NN denotes mucin
T3196 13787-13789 , denotes ,
T3197 13789-13793 NN denotes Muc2
T3198 13793-13794 . denotes .
T3199 13794-13944 sentence denotes In wild type intestine, B6 mice had 0.079 +/- 0.024 copies of Muc2/GAPDH (n = 8), and on the mixed background the level was 0.077 +/- 0.012 (n = 11).
T3200 13795-13797 IN denotes In
T3201 13827-13830 VBD denotes had
T3202 13798-13802 JJ denotes wild
T3203 13803-13807 NN denotes type
T3204 13808-13817 NN denotes intestine
T3205 13817-13819 , denotes ,
T3206 13819-13821 NN denotes B6
T3207 13822-13826 NNS denotes mice
T3208 13831-13836 CD denotes 0.079
T3209 13841-13846 CD denotes 0.024
T3210 13837-13838 SYM denotes +
T3211 13838-13839 HYPH denotes /
T3212 13839-13840 SYM denotes -
T3213 13847-13853 NNS denotes copies
T3214 13854-13856 IN denotes of
T3215 13857-13861 NN denotes Muc2
T3216 13862-13867 NN denotes GAPDH
T3217 13861-13862 HYPH denotes /
T3218 13868-13869 -LRB- denotes (
T3219 13873-13874 CD denotes 8
T3220 13869-13870 NN denotes n
T3221 13871-13872 SYM denotes =
T3222 13874-13875 -RRB- denotes )
T3223 13875-13877 , denotes ,
T3224 13877-13880 CC denotes and
T3225 13881-13883 IN denotes on
T3226 13915-13918 VBD denotes was
T3227 13884-13887 DT denotes the
T3228 13894-13904 NN denotes background
T3229 13888-13893 JJ denotes mixed
T3230 13905-13908 DT denotes the
T3231 13909-13914 NN denotes level
T3232 13919-13924 CD denotes 0.077
T3233 13929-13934 CD denotes 0.012
T3234 13925-13926 SYM denotes +
T3235 13926-13927 HYPH denotes /
T3236 13927-13928 SYM denotes -
T3237 13935-13936 -LRB- denotes (
T3238 13940-13942 CD denotes 11
T3239 13936-13937 NN denotes n
T3240 13938-13939 SYM denotes =
T3241 13942-13943 -RRB- denotes )
T3242 13943-13944 . denotes .
T3243 13944-14101 sentence denotes CF mice on the B6 background had 0.059 +/- 0.024 copies of Muc2 mRNA per GAPDH (n = 11), and on the mixed background the level was 0.056 +/- 0.010 (n = 11).
T3244 13945-13947 NN denotes CF
T3245 13948-13952 NNS denotes mice
T3246 13974-13977 VBD denotes had
T3247 13953-13955 IN denotes on
T3248 13956-13959 DT denotes the
T3249 13963-13973 NN denotes background
T3250 13960-13962 NN denotes B6
T3251 13978-13983 CD denotes 0.059
T3252 13988-13993 CD denotes 0.024
T3253 13984-13985 SYM denotes +
T3254 13985-13986 HYPH denotes /
T3255 13986-13987 SYM denotes -
T3256 13994-14000 NNS denotes copies
T3257 14001-14003 IN denotes of
T3258 14004-14008 NN denotes Muc2
T3259 14009-14013 NN denotes mRNA
T3260 14014-14017 IN denotes per
T3261 14018-14023 NN denotes GAPDH
T3262 14024-14025 -LRB- denotes (
T3263 14029-14031 CD denotes 11
T3264 14025-14026 NN denotes n
T3265 14027-14028 SYM denotes =
T3266 14031-14032 -RRB- denotes )
T3267 14032-14034 , denotes ,
T3268 14034-14037 CC denotes and
T3269 14038-14040 IN denotes on
T3270 14072-14075 VBD denotes was
T3271 14041-14044 DT denotes the
T3272 14051-14061 NN denotes background
T3273 14045-14050 JJ denotes mixed
T3274 14062-14065 DT denotes the
T3275 14066-14071 NN denotes level
T3276 14076-14081 CD denotes 0.056
T3277 14086-14091 CD denotes 0.010
T3278 14082-14083 SYM denotes +
T3279 14083-14084 HYPH denotes /
T3280 14084-14085 SYM denotes -
T3281 14092-14093 -LRB- denotes (
T3282 14097-14099 CD denotes 11
T3283 14093-14094 NN denotes n
T3284 14095-14096 SYM denotes =
T3285 14099-14100 -RRB- denotes )
T3286 14100-14101 . denotes .
T3287 14101-14258 sentence denotes Despite the increased mucus accumulation in CF, there is a slight decrease in Muc2 mRNA in the CF small intestine (P < 0.0001), as previously reported [33].
T3288 14102-14109 IN denotes Despite
T3289 14156-14158 VBZ denotes is
T3290 14110-14113 DT denotes the
T3291 14130-14142 NN denotes accumulation
T3292 14114-14123 VBN denotes increased
T3293 14124-14129 NN denotes mucus
T3294 14143-14145 IN denotes in
T3295 14146-14148 NN denotes CF
T3296 14148-14150 , denotes ,
T3297 14150-14155 EX denotes there
T3298 14159-14160 DT denotes a
T3299 14168-14176 NN denotes decrease
T3300 14161-14167 JJ denotes slight
T3301 14177-14179 IN denotes in
T3302 14180-14184 NN denotes Muc2
T3303 14185-14189 NN denotes mRNA
T3304 14190-14192 IN denotes in
T3305 14193-14196 DT denotes the
T3306 14206-14215 NN denotes intestine
T3307 14197-14199 NN denotes CF
T3308 14200-14205 JJ denotes small
T3309 14216-14217 -LRB- denotes (
T3310 14221-14227 CD denotes 0.0001
T3311 14217-14218 NN denotes P
T3312 14219-14220 SYM denotes <
T3313 14227-14228 -RRB- denotes )
T3314 14228-14230 , denotes ,
T3315 14230-14232 IN denotes as
T3316 14244-14252 VBN denotes reported
T3317 14233-14243 RB denotes previously
T3318 14253-14254 -LRB- denotes [
T3319 14254-14256 CD denotes 33
T3320 14256-14257 -RRB- denotes ]
T3321 14257-14258 . denotes .
T3322 14258-14406 sentence denotes However, the milder CF phenotype on the mixed background, which includes less mucus accumulation, does not involve decreased mucin gene expression.
T3323 14259-14266 RB denotes However
T3324 14366-14373 VB denotes involve
T3325 14266-14268 , denotes ,
T3326 14268-14271 DT denotes the
T3327 14282-14291 NN denotes phenotype
T3328 14272-14278 JJR denotes milder
T3329 14279-14281 NN denotes CF
T3330 14292-14294 IN denotes on
T3331 14295-14298 DT denotes the
T3332 14305-14315 NN denotes background
T3333 14299-14304 JJ denotes mixed
T3334 14315-14317 , denotes ,
T3335 14317-14322 WDT denotes which
T3336 14323-14331 VBZ denotes includes
T3337 14332-14336 JJ denotes less
T3338 14343-14355 NN denotes accumulation
T3339 14337-14342 NN denotes mucus
T3340 14355-14357 , denotes ,
T3341 14357-14361 VBZ denotes does
T3342 14362-14365 RB denotes not
T3343 14374-14383 VBN denotes decreased
T3344 14395-14405 NN denotes expression
T3345 14384-14389 NN denotes mucin
T3346 14390-14394 NN denotes gene
T3347 14405-14406 . denotes .
T3428 14408-14410 NN denotes CF
T3429 14411-14415 NNS denotes mice
T3430 14440-14444 VBP denotes have
T3431 14416-14418 IN denotes on
T3432 14419-14422 DT denotes the
T3433 14429-14439 NN denotes background
T3434 14423-14428 JJ denotes mixed
T3435 14445-14453 VBN denotes improved
T3436 14454-14462 NN denotes survival
T3437 14462-14658 sentence denotes As reported by others [34], the expected number of Cftr null mice on the B6 background that survived to weaning was significantly less than that expected from Mendelian genetics (Tables 1 and 2).
T3438 14463-14465 IN denotes As
T3439 14466-14474 VBN denotes reported
T3440 14575-14578 VBD denotes was
T3441 14475-14477 IN denotes by
T3442 14478-14484 NNS denotes others
T3443 14485-14486 -LRB- denotes [
T3444 14486-14488 CD denotes 34
T3445 14488-14489 -RRB- denotes ]
T3446 14489-14491 , denotes ,
T3447 14491-14494 DT denotes the
T3448 14504-14510 NN denotes number
T3449 14495-14503 VBN denotes expected
T3450 14511-14513 IN denotes of
T3451 14514-14518 NN denotes Cftr
T3452 14524-14528 NNS denotes mice
T3453 14519-14523 JJ denotes null
T3454 14529-14531 IN denotes on
T3455 14532-14535 DT denotes the
T3456 14539-14549 NN denotes background
T3457 14536-14538 NN denotes B6
T3458 14550-14554 WDT denotes that
T3459 14555-14563 VBD denotes survived
T3460 14564-14566 IN denotes to
T3461 14567-14574 NN denotes weaning
T3462 14579-14592 RB denotes significantly
T3463 14593-14597 JJR denotes less
T3464 14598-14602 IN denotes than
T3465 14603-14607 DT denotes that
T3466 14608-14616 VBN denotes expected
T3467 14617-14621 IN denotes from
T3468 14622-14631 JJ denotes Mendelian
T3469 14632-14640 NN denotes genetics
T3470 14641-14642 -LRB- denotes (
T3471 14649-14650 CD denotes 1
T3472 14642-14648 NNS denotes Tables
T3473 14651-14654 CC denotes and
T3474 14655-14656 CD denotes 2
T3475 14656-14657 -RRB- denotes )
T3476 14657-14658 . denotes .
T3477 14658-14729 sentence denotes The degree of significance was greater for male mice (Tables 1 and 2).
T3478 14659-14662 DT denotes The
T3479 14663-14669 NN denotes degree
T3480 14686-14689 VBD denotes was
T3481 14670-14672 IN denotes of
T3482 14673-14685 NN denotes significance
T3483 14690-14697 JJR denotes greater
T3484 14698-14701 IN denotes for
T3485 14702-14706 JJ denotes male
T3486 14707-14711 NNS denotes mice
T3487 14712-14713 -LRB- denotes (
T3488 14720-14721 CD denotes 1
T3489 14713-14719 NNS denotes Tables
T3490 14722-14725 CC denotes and
T3491 14726-14727 CD denotes 2
T3492 14727-14728 -RRB- denotes )
T3493 14728-14729 . denotes .
T3494 14729-14879 sentence denotes In contrast, on the mixed background, the distribution of genotypes of female offspring was not significantly different from the expected (Tables 1).
T3495 14730-14732 IN denotes In
T3496 14818-14821 VBD denotes was
T3497 14733-14741 NN denotes contrast
T3498 14741-14743 , denotes ,
T3499 14743-14745 IN denotes on
T3500 14746-14749 DT denotes the
T3501 14756-14766 NN denotes background
T3502 14750-14755 JJ denotes mixed
T3503 14766-14768 , denotes ,
T3504 14768-14771 DT denotes the
T3546 14997-14998 -LRB- denotes (
T3547 14998-15003 NN denotes Table
T3548 15004-15005 CD denotes 2
T3549 15005-15006 -RRB- denotes )
T3550 15006-15007 . denotes .
T3551 15007-15103 sentence denotes These data indicate that the mixed background is associated with increased survival of CF mice.
T3552 15008-15013 DT denotes These
T3553 15014-15018 NNS denotes data
T3554 15019-15027 VBP denotes indicate
T3555 15028-15032 IN denotes that
T3556 15057-15067 VBN denotes associated
T3557 15033-15036 DT denotes the
T3558 15043-15053 NN denotes background
T3559 15037-15042 JJ denotes mixed
T3560 15054-15056 VBZ denotes is
T3561 15068-15072 IN denotes with
T3562 15073-15082 VBN denotes increased
T3563 15083-15091 NN denotes survival
T3564 15092-15094 IN denotes of
T3565 15095-15097 NN denotes CF
T3566 15098-15102 NNS denotes mice
T3567 15102-15103 . denotes .
T5007 21442-21456 NN denotes responsiveness
T5421 23417-23418 . denotes .
T6584 6417-6423 NN denotes Effect
T6585 6424-6426 IN denotes of
T6586 6427-6434 JJ denotes genetic
T6587 6435-6445 NN denotes background
T6588 6446-6448 IN denotes on
T6589 6449-6453 NN denotes body
T6590 6454-6461 NNS denotes weights
T6591 6462-6464 IN denotes of
T6592 6465-6467 NN denotes CF
T6593 6468-6472 NNS denotes mice
T6594 6472-6473 . denotes .
T6595 6473-6540 sentence denotes (A) Female and (B) male mice were weighed at 4 and 8 weeks of age.
T6596 6474-6475 -LRB- denotes (
T6597 6475-6476 NN denotes A
T6598 6478-6484 JJ denotes Female
T6599 6476-6477 -RRB- denotes )
T6600 6498-6502 NNS denotes mice
T6601 6485-6488 CC denotes and
T6602 6489-6490 -LRB- denotes (
T6603 6490-6491 NN denotes B
T6604 6493-6497 JJ denotes male
T6605 6491-6492 -RRB- denotes )
T6606 6508-6515 VBN denotes weighed
T6607 6503-6507 VBD denotes were
T6608 6516-6518 IN denotes at
T6609 6519-6520 CD denotes 4
T6610 6527-6532 NNS denotes weeks
T6611 6521-6524 CC denotes and
T6612 6525-6526 CD denotes 8
T6613 6533-6535 IN denotes of
T6614 6536-6539 NN denotes age
T6615 6539-6540 . denotes .
T6616 6540-6562 sentence denotes Data are means ± SEM.
T6617 6541-6545 NNS denotes Data
T6618 6546-6549 VBP denotes are
T6619 6550-6555 NNS denotes means
T6620 6558-6561 NN denotes SEM
T6621 6556-6557 SYM denotes ±
T6622 6561-6562 . denotes .
T6623 6562-6637 sentence denotes (*) P < 0.001 vs other three groups by ANOVA with a post-hoc Tukey's test.
T6624 6563-6564 -LRB- denotes (
T6625 6564-6565 LS denotes *
T6626 6571-6576 CD denotes 0.001
T6627 6565-6566 -RRB- denotes )
T6628 6567-6568 NN denotes P
T6629 6569-6570 SYM denotes <
T6630 6577-6579 CC denotes vs
T6631 6580-6585 JJ denotes other
T6632 6592-6598 NNS denotes groups
T6633 6586-6591 CD denotes three
T6634 6599-6601 IN denotes by
T6635 6602-6607 NN denotes ANOVA
T6636 6608-6612 IN denotes with
T6637 6613-6614 DT denotes a
T6638 6632-6636 NN denotes test
T6639 6615-6623 JJ denotes post-hoc
T6640 6624-6629 NNP denotes Tukey
T6641 6629-6631 POS denotes 's
T6642 6636-6637 . denotes .
T6643 6637-6709 sentence denotes There were no significant differences for any of the other comparisons.
T6644 6638-6643 EX denotes There
T6645 6644-6648 VBD denotes were
T6646 6649-6651 DT denotes no
T6647 6664-6675 NNS denotes differences
T6648 6652-6663 JJ denotes significant
T6649 6676-6679 IN denotes for
T6650 6680-6683 DT denotes any
T6651 6684-6686 IN denotes of
T6652 6687-6690 DT denotes the
T6653 6697-6708 NNS denotes comparisons
T6654 6691-6696 JJ denotes other
T6655 6708-6709 . denotes .
T6656 6709-6900 sentence denotes Data were obtained from: 65 wild type and 26 CF B6 females, 36 wild type and 8 CF mixed background females, 68 wild type and 30 CF B6 males, and 37 wild type and 6 CF mixed background males.
T6657 6710-6714 NNS denotes Data
T6658 6720-6728 VBN denotes obtained
T6659 6715-6719 VBD denotes were
T6660 6729-6733 IN denotes from
T6661 6733-6735 : denotes :
T6662 6735-6737 CD denotes 65
T6663 6743-6747 NN denotes type
T6664 6738-6742 JJ denotes wild
T6665 6748-6751 CC denotes and
T6666 6752-6754 CD denotes 26
T6667 6758-6760 NN denotes B6
T6668 6755-6757 NN denotes CF
T6669 6761-6768 NNS denotes females
T6670 6768-6770 , denotes ,
T6671 6770-6772 CD denotes 36
T6672 6778-6782 NN denotes type
T6673 6773-6777 JJ denotes wild
T6674 6783-6786 CC denotes and
T6675 6787-6788 CD denotes 8
T6676 6798-6808 NN denotes background
T6677 6789-6791 NN denotes CF
T6678 6792-6797 JJ denotes mixed
T6679 6809-6816 NNS denotes females
T6680 6816-6818 , denotes ,
T6681 6818-6820 CD denotes 68
T6682 6826-6830 NN denotes type
T6683 6821-6825 JJ denotes wild
T6684 6831-6834 CC denotes and
T6685 6835-6837 CD denotes 30
T6686 6841-6843 NN denotes B6
T6687 6838-6840 NN denotes CF
T6688 6844-6849 NNS denotes males
T6689 6849-6851 , denotes ,
T6690 6851-6854 CC denotes and
T6691 6855-6857 CD denotes 37
T6692 6863-6867 NN denotes type
T6693 6858-6862 JJ denotes wild
T6694 6868-6871 CC denotes and
T6695 6872-6873 CD denotes 6
T6696 6883-6893 NN denotes background
T6697 6874-6876 NN denotes CF
T6698 6877-6882 JJ denotes mixed
T6699 6894-6899 NNS denotes males
T6700 6899-6900 . denotes .
T6751 9775-9781 NN denotes Effect
T6752 9782-9784 IN denotes of
T6753 9785-9792 JJ denotes genetic
T6754 9793-9803 NN denotes background
T6755 9804-9806 IN denotes on
T6756 9807-9819 JJ denotes inflammatory
T6757 9825-9835 NN denotes expression
T6758 9820-9824 NN denotes gene
T6759 9836-9838 IN denotes in
T6760 9839-9841 NN denotes CF
T6761 9842-9847 NN denotes mouse
T6762 9854-9863 NN denotes intestine
T6763 9848-9853 JJ denotes small
T6764 9863-9864 . denotes .
T6765 9864-9964 sentence denotes RNA expression levels were determined by quantitative real-time RT-PCR using gene-specific primers.
T6766 9865-9868 NN denotes RNA
T6767 9880-9886 NNS denotes levels
T6768 9869-9879 NN denotes expression
T6769 9892-9902 VBN denotes determined
T6770 9887-9891 VBD denotes were
T6771 9903-9905 IN denotes by
T6772 9906-9918 JJ denotes quantitative
T6773 9932-9935 NN denotes PCR
T6774 9919-9923 JJ denotes real
T6775 9924-9928 NN denotes time
T6776 9923-9924 HYPH denotes -
T6777 9929-9931 NN denotes RT
T6778 9931-9932 HYPH denotes -
T6779 9936-9941 VBG denotes using
T6780 9942-9946 NN denotes gene
T6781 9947-9955 JJ denotes specific
T6782 9946-9947 HYPH denotes -
T6783 9956-9963 NNS denotes primers
T6784 9963-9964 . denotes .
T6785 9964-10058 sentence denotes Data are expressed relative to GAPDH mRNA, which does not vary between wild type and CF mice.
T6786 9965-9969 NNS denotes Data
T6787 9974-9983 VBN denotes expressed
T6788 9970-9973 VBP denotes are
T6789 9984-9992 JJ denotes relative
T6790 9993-9995 IN denotes to
T6791 9996-10001 NN denotes GAPDH
T6792 10002-10006 NN denotes mRNA
T6793 10006-10008 , denotes ,
T6794 10008-10013 WDT denotes which
T6795 10023-10027 VB denotes vary
T6796 10014-10018 VBZ denotes does
T6797 10019-10022 RB denotes not
T6798 10028-10035 IN denotes between
T6799 10036-10040 JJ denotes wild
T6800 10041-10045 NN denotes type
T6801 10053-10057 NNS denotes mice
T6802 10046-10049 CC denotes and
T6803 10050-10052 NN denotes CF
T6804 10057-10058 . denotes .
T6805 10058-10080 sentence denotes Data are means ± SEM.
T6806 10059-10063 NNS denotes Data
T6807 10064-10067 VBP denotes are
T6808 10068-10073 NNS denotes means
T6809 10076-10079 NN denotes SEM
T6810 10074-10075 SYM denotes ±
T6811 10079-10080 . denotes .
T6812 10080-10240 sentence denotes (*) CF vs wild type on the B6 background, P < 0.005; (+) CF on the mixed background vs CF on the B6 background, P < 0.05 by ANOVA with a post-hoc Tukey's test.
T6813 10081-10082 -LRB- denotes (
T6814 10082-10083 LS denotes *
T6815 10127-10132 CD denotes 0.005
T6816 10083-10084 -RRB- denotes )
T6817 10085-10087 NN denotes CF
T6818 10088-10090 CC denotes vs
T6819 10091-10095 JJ denotes wild
T6820 10096-10100 NN denotes type
T6821 10101-10103 IN denotes on
T6822 10104-10107 DT denotes the
T6823 10111-10121 NN denotes background
T6824 10108-10110 NN denotes B6
T6825 10121-10123 , denotes ,
T6826 10123-10124 NN denotes P
T6827 10125-10126 SYM denotes <
T6828 10138-10140 NN denotes CF
T6829 10132-10133 : denotes ;
T6830 10134-10135 -LRB- denotes (
T6831 10135-10136 LS denotes +
T6832 10136-10137 -RRB- denotes )
T6833 10141-10143 IN denotes on
T6834 10144-10147 DT denotes the
T6835 10154-10164 NN denotes background
T6836 10148-10153 JJ denotes mixed
T6837 10165-10167 CC denotes vs
T6838 10168-10170 NN denotes CF
T6839 10171-10173 IN denotes on
T6840 10174-10177 DT denotes the
T6841 10181-10191 NN denotes background
T6842 10178-10180 NN denotes B6
T6843 10191-10193 , denotes ,
T6844 10193-10194 NN denotes P
T6845 10197-10201 CD denotes 0.05
T6846 10195-10196 SYM denotes <
T6847 10202-10204 IN denotes by
T6848 10205-10210 NN denotes ANOVA
T6849 10211-10215 IN denotes with
T6850 10216-10217 DT denotes a
T6851 10235-10239 NN denotes test
T6852 10218-10226 JJ denotes post-hoc
T6853 10227-10232 NNP denotes Tukey
T6854 10232-10234 POS denotes 's
T6855 10239-10240 . denotes .
T6856 10240-10431 sentence denotes There were no significant differences for any of the 6 genes comparing: wild type B6 mice vs wild type mixed background; or CF mice on the mixed background vs wild type on either background.
T6857 10241-10246 EX denotes There
T6858 10247-10251 VBD denotes were
T6859 10252-10254 DT denotes no
T6860 10267-10278 NNS denotes differences
T6861 10255-10266 JJ denotes significant
T6862 10279-10282 IN denotes for
T6863 10283-10286 DT denotes any
T6864 10287-10289 IN denotes of
T6865 10290-10293 DT denotes the
T6866 10296-10301 NNS denotes genes
T6867 10294-10295 CD denotes 6
T6868 10302-10311 VBG denotes comparing
T6869 10311-10313 : denotes :
T6870 10313-10317 JJ denotes wild
T6871 10318-10322 NN denotes type
T6872 10326-10330 NNS denotes mice
T6873 10323-10325 NN denotes B6
T6874 10331-10333 CC denotes vs
T6875 10334-10338 JJ denotes wild
T6876 10339-10343 NN denotes type
T6877 10350-10360 NN denotes background
T6878 10344-10349 JJ denotes mixed
T6879 10360-10361 : denotes ;
T6880 10362-10364 CC denotes or
T6881 10365-10367 NN denotes CF
T6882 10368-10372 NNS denotes mice
T6883 10373-10375 IN denotes on
T6884 10376-10379 DT denotes the
T6885 10386-10396 NN denotes background
T6886 10380-10385 JJ denotes mixed
T6887 10397-10399 CC denotes vs
T6888 10400-10404 JJ denotes wild
T6889 10405-10409 NN denotes type
T6890 10410-10412 IN denotes on
T6891 10413-10419 DT denotes either
T6892 10420-10430 NN denotes background
T6893 10430-10431 . denotes .
T6894 10431-10489 sentence denotes There were 8–11 samples analyzed per group for each gene.
T6895 10432-10437 EX denotes There
T6896 10438-10442 VBD denotes were
T6897 10443-10444 CD denotes 8
T6898 10445-10447 CD denotes 11
T6899 10444-10445 SYM denotes –
T6900 10448-10455 NNS denotes samples
T6901 10456-10464 VBN denotes analyzed
T6902 10465-10468 IN denotes per
T6903 10469-10474 NN denotes group
T6904 10475-10478 IN denotes for
T6905 10479-10483 DT denotes each
T6906 10484-10488 NN denotes gene
T6907 10488-10489 . denotes .
T6955 12411-12423 JJ denotes Histological
T6956 12424-12434 NN denotes appearance
T6957 12435-12437 IN denotes of
T6958 12438-12441 DT denotes the
T6959 12448-12457 NN denotes intestine
T6960 12442-12447 JJ denotes small
T6961 12458-12460 IN denotes of
T6962 12461-12465 JJ denotes wild
T6963 12466-12470 NN denotes type
T6964 12478-12482 NNS denotes mice
T6965 12471-12474 CC denotes and
T6966 12475-12477 NN denotes CF
T6967 12483-12485 IN denotes on
T6968 12486-12489 DT denotes the
T6969 12508-12519 NNS denotes backgrounds
T6970 12490-12499 JJ denotes different
T6971 12500-12507 JJ denotes genetic
T6972 12519-12520 . denotes .
T6973 12520-12590 sentence denotes Tissue was paraffin embedded and stained with PAS for neutral mucins.
T6974 12521-12527 NN denotes Tissue
T6975 12541-12549 VBN denotes embedded
T6976 12528-12531 VBD denotes was
T6977 12532-12540 NN denotes paraffin
T6978 12550-12553 CC denotes and
T6979 12554-12561 VBN denotes stained
T6980 12562-12566 IN denotes with
T6981 12567-12570 NN denotes PAS
T6982 12571-12574 IN denotes for
T6983 12575-12582 JJ denotes neutral
T6984 12583-12589 NNS denotes mucins
T6985 12589-12590 . denotes .
T6986 12590-12654 sentence denotes The sections are from the middle portion of the small intestine
T6987 12591-12594 DT denotes The
T6988 12595-12603 NNS denotes sections
T6989 12604-12607 VBP denotes are
T6990 12608-12612 IN denotes from
T6991 12613-12616 DT denotes the
T6992 12624-12631 NN denotes portion
T6993 12617-12623 JJ denotes middle
T6994 12632-12634 IN denotes of
T6995 12635-12638 DT denotes the
T6996 12645-12654 NN denotes intestine
T6997 12639-12644 JJ denotes small
T6998 12654-12690 sentence denotes (A) Wild type on the B6 background.
T6999 12655-12656 -LRB- denotes (
T7000 12656-12657 LS denotes A
T7001 12664-12668 NN denotes type
T7002 12657-12658 -RRB- denotes )
T7003 12659-12663 JJ denotes Wild
T7004 12669-12671 IN denotes on
T7005 12672-12675 DT denotes the
T7006 12679-12689 NN denotes background
T7007 12676-12678 NN denotes B6
T7008 12689-12690 . denotes .
T7009 12690-12719 sentence denotes (B) CF on the B6 background.
T7010 12691-12692 -LRB- denotes (
T7011 12692-12693 LS denotes B
T7012 12695-12697 NN denotes CF
T7013 12693-12694 -RRB- denotes )
T7014 12698-12700 IN denotes on
T7015 12701-12704 DT denotes the
T7016 12708-12718 NN denotes background
T7017 12705-12707 NN denotes B6
T7018 12718-12719 . denotes .
T7019 12719-12758 sentence denotes (C) Wild type on the mixed background.
T7020 12720-12721 -LRB- denotes (
T7021 12721-12722 LS denotes C
T7022 12729-12733 NN denotes type
T7023 12722-12723 -RRB- denotes )
T7024 12724-12728 JJ denotes Wild
T7025 12734-12736 IN denotes on
T7026 12737-12740 DT denotes the
T7027 12747-12757 NN denotes background
T7028 12741-12746 JJ denotes mixed
T7029 12757-12758 . denotes .
T7030 12758-12792 sentence denotes (D-F) CF on the mixed background.
T7031 12759-12760 -LRB- denotes (
T7032 12760-12761 LS denotes D
T7033 12765-12767 NN denotes CF
T7034 12761-12762 HYPH denotes -
T7035 12762-12763 LS denotes F
T7036 12763-12764 -RRB- denotes )
T7037 12768-12770 IN denotes on
T7038 12771-12774 DT denotes the
T7039 12781-12791 NN denotes background
T7040 12775-12780 JJ denotes mixed
T7041 12791-12792 . denotes .
T7042 12792-12900 sentence denotes (A, C) In the wild type tissue from both backgrounds, the crypts are small and have narrow lumina (arrows).
T7043 12793-12794 -LRB- denotes (
T7044 12794-12795 LS denotes A
T7045 12858-12861 VBP denotes are
T7046 12795-12797 , denotes ,
T7047 12797-12798 LS denotes C
T7048 12798-12799 -RRB- denotes )
T7049 12800-12802 IN denotes In
T7050 12803-12806 DT denotes the
T7051 12817-12823 NN denotes tissue
T7052 12807-12811 JJ denotes wild
T7053 12812-12816 NN denotes type
T7054 12824-12828 IN denotes from
T7055 12829-12833 DT denotes both
T7056 12834-12845 NNS denotes backgrounds
T7057 12845-12847 , denotes ,
T7058 12847-12850 DT denotes the
T7059 12851-12857 NNS denotes crypts
T7060 12862-12867 JJ denotes small
T7061 12868-12871 CC denotes and
T7062 12872-12876 VBP denotes have
T7063 12877-12883 JJ denotes narrow
T7064 12884-12890 NNS denotes lumina
T7065 12891-12892 -LRB- denotes (
T7066 12892-12898 NNS denotes arrows
T7067 12898-12899 -RRB- denotes )
T7068 12899-12900 . denotes .
T7069 12900-13025 sentence denotes (B) In the CF tissue on the B6 background, the crypt lumina are greatly dilated and filled with PAS-reactive mucus (arrows).
T7070 12901-12902 -LRB- denotes (
T7071 12902-12903 LS denotes B
T7072 12961-12964 VBP denotes are
T7073 12903-12904 -RRB- denotes )
T7074 12905-12907 IN denotes In
T7075 12908-12911 DT denotes the
T7076 12915-12921 NN denotes tissue
T7077 12912-12914 NN denotes CF
T7078 12922-12924 IN denotes on
T7079 12925-12928 DT denotes the
T7080 12932-12942 NN denotes background
T7081 12929-12931 NN denotes B6
T7082 12942-12944 , denotes ,
T7083 12944-12947 DT denotes the
T7084 12954-12960 NNS denotes lumina
T7085 12948-12953 NN denotes crypt
T7086 12965-12972 RB denotes greatly
T7087 12973-12980 VBN denotes dilated
T7088 12981-12984 CC denotes and
T7089 12985-12991 VBN denotes filled
T7090 12992-12996 IN denotes with
T7091 12997-13000 NN denotes PAS
T7092 13001-13009 JJ denotes reactive
T7093 13000-13001 HYPH denotes -
T7094 13010-13015 NN denotes mucus
T7095 13016-13017 -LRB- denotes (
T7096 13017-13023 NNS denotes arrows
T7097 13023-13024 -RRB- denotes )
T7098 13024-13025 . denotes .
T7099 13025-13172 sentence denotes In some CF mice on the mixed background, the crypts are not apparently different than wild type (D), and the crypts are normal appearing (arrows).
T7100 13026-13028 IN denotes In
T7101 13078-13081 VBP denotes are
T7102 13029-13033 DT denotes some
T7103 13037-13041 NNS denotes mice
T7104 13034-13036 NN denotes CF
T7105 13042-13044 IN denotes on
T7106 13045-13048 DT denotes the
T7107 13055-13065 NN denotes background
T7108 13049-13054 JJ denotes mixed
T7109 13065-13067 , denotes ,
T7110 13067-13070 DT denotes the
T7111 13071-13077 NNS denotes crypts
T7112 13082-13085 RB denotes not
T7113 13086-13096 RB denotes apparently
T7114 13097-13106 JJ denotes different
T7115 13107-13111 IN denotes than
T7116 13112-13116 JJ denotes wild
T7117 13117-13121 NN denotes type
T7118 13122-13123 -LRB- denotes (
T7119 13123-13124 NN denotes D
T7120 13124-13125 -RRB- denotes )
T7121 13125-13127 , denotes ,
T7122 13127-13130 CC denotes and
T7123 13131-13134 DT denotes the
T7124 13135-13141 NNS denotes crypts
T7125 13142-13145 VBP denotes are
T7126 13146-13152 JJ denotes normal
T7127 13153-13162 VBG denotes appearing
T7128 13163-13164 -LRB- denotes (
T7129 13164-13170 NNS denotes arrows
T7130 13170-13171 -RRB- denotes )
T7131 13171-13172 . denotes .
T7132 13172-13309 sentence denotes Some CF mice on the mixed background had mildly affected crypts (E), while others had greater crypt dilation and mucus accumulation (F).
T7133 13173-13177 DT denotes Some
T7134 13181-13185 NNS denotes mice
T7135 13178-13180 NN denotes CF
T7136 13210-13213 VBD denotes had
T7137 13186-13188 IN denotes on
T7138 13189-13192 DT denotes the
T7139 13199-13209 NN denotes background
T7140 13193-13198 JJ denotes mixed
T7141 13214-13220 RB denotes mildly
T7142 13230-13236 NNS denotes crypts
T7143 13221-13229 VBN denotes affected
T7144 13237-13238 -LRB- denotes (
T7145 13238-13239 NN denotes E
T7146 13239-13240 -RRB- denotes )
T7147 13240-13242 , denotes ,
T7148 13242-13247 IN denotes while
T7149 13255-13258 VBD denotes had
T7150 13248-13254 NNS denotes others
T7151 13259-13266 JJR denotes greater
T7152 13273-13281 NN denotes dilation
T7153 13267-13272 NN denotes crypt
T7154 13282-13285 CC denotes and
T7155 13286-13291 NN denotes mucus
T7156 13292-13304 NN denotes accumulation
T7157 13305-13306 -LRB- denotes (
T7158 13306-13307 NN denotes F
T7159 13307-13308 -RRB- denotes )
T7160 13308-13309 . denotes .
T7161 13309-13422 sentence denotes Overall, the CF mice on the mixed background were less severely affected compared to those on the B6 background.
T7162 13310-13317 RB denotes Overall
T7163 13374-13382 VBN denotes affected
T7164 13317-13319 , denotes ,
T7165 13319-13322 DT denotes the
T7166 13326-13330 NNS denotes mice
T7167 13323-13325 NN denotes CF
T7168 13331-13333 IN denotes on
T7169 13334-13337 DT denotes the
T7170 13344-13354 NN denotes background
T7171 13338-13343 JJ denotes mixed
T7172 13355-13359 VBD denotes were
T7173 13360-13364 RBR denotes less
T7174 13365-13373 RB denotes severely
T7175 13383-13391 VBN denotes compared
T7176 13392-13394 IN denotes to
T7177 13395-13400 DT denotes those
T7178 13401-13403 IN denotes on
T7179 13404-13407 DT denotes the
T7180 13411-13421 NN denotes background
T7181 13408-13410 NN denotes B6
T7182 13421-13422 . denotes .
T7375 15113-15125 NN denotes Distribution
T7376 15126-15128 IN denotes of
T7377 15129-15133 NN denotes Cftr
T7378 15134-15143 NNS denotes genotypes
T7379 15144-15146 IN denotes in
T7380 15147-15153 JJ denotes female
T7381 15154-15163 NN denotes offspring
T7382 15164-15168 IN denotes from
T7383 15169-15177 VBG denotes breeding
T7384 15178-15182 NN denotes Cftr
T7385 15183-15196 NNS denotes heterozygotes
T7386 15197-15199 IN denotes on
T7387 15200-15203 DT denotes the
T7388 15217-15228 NNS denotes backgrounds
T7389 15204-15206 NN denotes B6
T7390 15207-15210 CC denotes and
T7391 15211-15216 JJ denotes mixed
T7392 15228-15229 . denotes .
T7436 18787-18788 . denotes .
T7435 18771-18776 JJ denotes mixed
T7434 18777-18787 NN denotes background
T7433 18767-18770 DT denotes the
T7432 18764-18766 IN denotes on
T7431 18759-18763 NNS denotes mice
T7430 18756-18758 NN denotes CF
T7429 18753-18755 IN denotes of
T7428 18735-18743 NN denotes scanning
T7427 18744-18752 NN denotes analysis
T7426 18728-18734 NN denotes Genome
T7420 15721-15722 . denotes .
T3545 14988-14990 NN denotes B6
T3583 16173-16184 NN denotes obstruction
T3582 16162-16172 JJ denotes intestinal
T3581 16158-16161 CC denotes and
T3580 16156-16158 , denotes ,
T3579 16145-16156 NN denotes obstruction
T3578 16134-16144 JJ denotes intestinal
T3577 16126-16130 NNS denotes mice
T3576 16123-16125 NN denotes CF
T3575 16120-16122 IN denotes in
T3574 16114-16119 NN denotes death
T3573 16111-16113 IN denotes of
T3572 16131-16133 VBZ denotes is
T3571 16099-16104 JJ denotes major
T3570 16105-16110 NN denotes cause
T3569 15104-16098 DT denotes Table 1 Distribution of Cftr genotypes in female offspring from breeding Cftr heterozygotes on the B6 and mixed backgrounds. B6 Background Mixed Background Cftr Observed Expected Observed Expected +/+ 207 175 57 47 +/- 371 350 88 94 -/- 122 175 42 47 P 0.00001 (0.04533)* 0.21724 Statistical analysis was by Chi-square. (*) P-value if the sample size for the B6 mice is adjusted to be equal to that of the mixed background mice, assuming the same distribution of genotypes. Table 2 Distribution of Cftr genotypes in male offspring from breeding Cftr heterozygotes on the B6 and mixed backgrounds. B6 Background Mixed Background Cftr Observed Expected Observed Expected +/+ 240 201 57 52 +/- 431 403 115 104 -/- 134 201 36 52 P <0.00001 (0.01612)* 0.03749 Statistical analysis was by Chi-square. (*) P-value if the sample size for the B6 mice is adjusted to be equal to that of the mixed background mice, assuming the same distribution of genotypes. The
T3568 15103-16250 sentence denotes Table 1 Distribution of Cftr genotypes in female offspring from breeding Cftr heterozygotes on the B6 and mixed backgrounds. B6 Background Mixed Background Cftr Observed Expected Observed Expected +/+ 207 175 57 47 +/- 371 350 88 94 -/- 122 175 42 47 P 0.00001 (0.04533)* 0.21724 Statistical analysis was by Chi-square. (*) P-value if the sample size for the B6 mice is adjusted to be equal to that of the mixed background mice, assuming the same distribution of genotypes. Table 2 Distribution of Cftr genotypes in male offspring from breeding Cftr heterozygotes on the B6 and mixed backgrounds. B6 Background Mixed Background Cftr Observed Expected Observed Expected +/+ 240 201 57 52 +/- 431 403 115 104 -/- 134 201 36 52 P <0.00001 (0.01612)* 0.03749 Statistical analysis was by Chi-square. (*) P-value if the sample size for the B6 mice is adjusted to be equal to that of the mixed background mice, assuming the same distribution of genotypes. The major cause of death in CF mice is intestinal obstruction, and intestinal obstruction is worsened when the mice are fed standard solid mouse chow [35].
T3505 14772-14784 NN denotes distribution
T3506 14785-14787 IN denotes of
T3507 14788-14797 NNS denotes genotypes
T3508 14798-14800 IN denotes of
T3509 14801-14807 JJ denotes female
T3510 14808-14817 NN denotes offspring
T3511 14822-14825 RB denotes not
T3512 14826-14839 RB denotes significantly
T3513 14840-14849 JJ denotes different
T3514 14850-14854 IN denotes from
T3515 14855-14858 DT denotes the
T3516 14859-14867 VBN denotes expected
T3517 14868-14869 -LRB- denotes (
T3518 14869-14875 NNS denotes Tables
T3519 14876-14877 CD denotes 1
T3520 14877-14878 -RRB- denotes )
T3521 14878-14879 . denotes .
T3522 14879-15007 sentence denotes For male mice on the mixed background, the P-value was less significant but still different compared to the B6 males (Table 2).
T3523 14880-14883 IN denotes For
T3524 14931-14934 VBD denotes was
T3525 14884-14888 JJ denotes male
T3526 14889-14893 NNS denotes mice
T3527 14894-14896 IN denotes on
T3528 14897-14900 DT denotes the
T3529 14907-14917 NN denotes background
T3530 14901-14906 JJ denotes mixed
T3531 14917-14919 , denotes ,
T3532 14919-14922 DT denotes the
T3533 14925-14930 NN denotes value
T3534 14923-14924 NN denotes P
T3535 14924-14925 HYPH denotes -
T3536 14935-14939 RBR denotes less
T3537 14940-14951 JJ denotes significant
T3538 14952-14955 CC denotes but
T3539 14956-14961 RB denotes still
T3540 14962-14971 JJ denotes different
T3541 14972-14980 VBN denotes compared
T3542 14981-14983 IN denotes to
T3543 14984-14987 DT denotes the
T3544 14991-14996 NNS denotes males
T154 107-109 , denotes ,
T2536 9644-9648 JJ denotes wild
T2537 9649-9653 NN denotes type
T2538 9653-9655 , denotes ,
T2539 9655-9658 CC denotes and
T2540 9659-9661 IN denotes on
T3049 12000-12003 DT denotes the
T3050 12004-12010 NNS denotes crypts
T3051 12011-12012 -LRB- denotes (
T3052 12012-12016 NN denotes Fig.
T3053 12017-12019 CD denotes 3E
T3054 12019-12020 -RRB- denotes )
T3055 12020-12022 , denotes ,
T3056 12022-12027 IN denotes while
T3057 12035-12038 VBD denotes had
T3058 12028-12034 NNS denotes others
T3059 12039-12047 JJ denotes moderate
T3060 12054-12066 NN denotes accumulation
T3061 12048-12053 NN denotes mucus
T3062 12067-12068 -LRB- denotes (
T3063 12068-12072 NN denotes Fig.
T3064 12073-12075 CD denotes 3F
T3065 12075-12076 -RRB- denotes )
T3066 12076-12077 . denotes .
T3067 12077-12241 sentence denotes A total of six CF mice on the mixed background were examined histologically, and three had little mucus, one had some mucus, and two had moderate amounts of mucus.
T3068 12078-12079 DT denotes A
T3069 12080-12085 NN denotes total
T3070 12130-12138 VBN denotes examined
T3071 12086-12088 IN denotes of
T2541 9707-9710 VBD denotes was
T3131 12400-13602 sentence denotes Figure 3 Histological appearance of the small intestine of wild type and CF mice on the different genetic backgrounds. Tissue was paraffin embedded and stained with PAS for neutral mucins. The sections are from the middle portion of the small intestine (A) Wild type on the B6 background. (B) CF on the B6 background. (C) Wild type on the mixed background. (D-F) CF on the mixed background. (A, C) In the wild type tissue from both backgrounds, the crypts are small and have narrow lumina (arrows). (B) In the CF tissue on the B6 background, the crypt lumina are greatly dilated and filled with PAS-reactive mucus (arrows). In some CF mice on the mixed background, the crypts are not apparently different than wild type (D), and the crypts are normal appearing (arrows). Some CF mice on the mixed background had mildly affected crypts (E), while others had greater crypt dilation and mucus accumulation (F). Overall, the CF mice on the mixed background were less severely affected compared to those on the B6 background. Thus, it appears that whatever the nature of the genetic differences between the two background strains, they affect secretion and accumulation of mucus in the CF small intestine.
T3132 13423-13427 RB denotes Thus
T786 2187-2193 JJ denotes Cystic
T787 2194-2202 NN denotes fibrosis
T788 2211-2217 VBN denotes caused
T2499 9452-9455 CC denotes but
T2500 9456-9458 IN denotes on
T2501 9512-9515 VBD denotes was
T2502 9459-9462 DT denotes the
T2503 9469-9479 NN denotes background
T2504 9463-9468 JJ denotes mixed
T2505 9480-9483 DT denotes the
T2506 9495-9500 NN denotes level
T2507 9484-9494 NN denotes expression
T2508 9501-9503 IN denotes in
T2509 9504-9506 NN denotes CF
T2510 9507-9511 NNS denotes mice
T2511 9516-9519 RB denotes not
T2512 9520-9533 RB denotes significantly
T2513 9534-9543 JJ denotes different
T2514 9544-9548 IN denotes than
T2515 9549-9553 JJ denotes wild
T2516 9554-9558 NN denotes type
T2517 9559-9560 -LRB- denotes (
T2518 9560-9564 NN denotes Fig.
T2519 9565-9567 CD denotes 2E
T2520 9567-9568 -RRB- denotes )
T2521 9568-9569 . denotes .
T2522 9569-9764 sentence denotes Finally, HemT1 was overexpressed almost 20-fold in B6 CF mice compared to wild type, and on the mixed background the CF expression level was not statistically different from wild type (Fig. 2F).
T2523 9570-9577 RB denotes Finally
T2524 9589-9602 VBN denotes overexpressed
T2525 9577-9579 , denotes ,
T2526 9579-9584 NN denotes HemT1
T2527 9585-9588 VBD denotes was
T2528 9603-9609 RB denotes almost
T2529 9610-9617 RB denotes 20-fold
T2530 9618-9620 IN denotes in
T2531 9621-9623 NN denotes B6
T2532 9627-9631 NNS denotes mice
T2533 9624-9626 NN denotes CF
T2534 9632-9640 VBN denotes compared
T2535 9641-9643 IN denotes to
T789 2203-2204 -LRB- denotes (
T790 2204-2206 NN denotes CF
T791 2206-2207 -RRB- denotes )
T792 2208-2210 VBZ denotes is
T793 2218-2220 IN denotes by
T794 2221-2230 NNS denotes mutations
T4573 19507-19508 NNS denotes p
T4572 19508-19509 VBN denotes a
T4571 19507-19509 sentence denotes pa
T4570 19502-19505 DT denotes the
T4569 19506-19507 NNS denotes s
T4568 19502-19507 sentence denotes the s
T4567 19500-19501 VBN denotes e
T4566 19500-19502 sentence denotes e
T4565 19497-19500 NNS denotes aus
T4564 19496-19497 NNS denotes c
T4563 19495-19496 NNS denotes e
T4562 19494-19495 NN denotes B
T4561 19494-19500 sentence denotes Becaus
T4560 18718-18719 sentence denotes
T4559 18717-18718 . denotes .
T4558 18716-18717 -RRB- denotes )
T4557 18705-18708 CD denotes 129
T4556 18701-18704 CC denotes and
T4555 18709-18716 NNS denotes alleles
T4554 18698-18700 NN denotes B6
T4553 18693-18697 CC denotes both
T4552 18684-18688 NNS denotes mice
T4551 18681-18683 CD denotes 10
T4550 18689-18692 VBD denotes had
T4581 19616-19622 VBN denotes looked
T4580 19525-19529 VBN denotes used
T4579 19517-19524 NNS denotes markers
T4578 19514-19516 IN denotes of
T4577 19510-19513 NN denotes ing
T4576 19530-19533 VBD denotes was
T4575 19509-19510 IN denotes c
T4574 19509-19688 sentence denotes cing of markers used was about 12 cM, genes within 75% of this interval on either side of the markers were looked at for potential relevance to the milder CF intestinal phenotype.
R79 T227 T228 amod distal,obstruction
R5 T145 T143 pobj phenotype,of
R6 T146 T147 amod cystic,fibrosis
R7 T147 T145 nmod fibrosis,phenotype
R8 T148 T145 amod intestinal,phenotype
R9 T149 T145 amod inflammatory,phenotype
R12 T152 T150 pobj 1,on
R13 T153 T152 nmod chromosomes,1
R14 T155 T152 conj 9,1
R15 T156 T155 punct ", ",9
R16 T157 T155 cc and,9
R17 T158 T155 conj 10,9
R18 T163 T164 mark Although,caused
R19 T164 T168 advcl caused,is
R23 T169 T164 agent by,caused
R24 T170 T169 pobj mutations,by
R25 T171 T170 prep in,mutations
R26 T172 T173 det the,gene
R27 T173 T171 pobj gene,in
R29 T175 T173 nmod regulator,gene
R30 T176 T175 nmod fibrosis,regulator
R31 T177 T175 amod transmembrane,regulator
R32 T178 T175 nmod conductance,regulator
R36 T182 T168 punct ", ",is
R37 T183 T184 det the,severity
R38 T184 T168 nsubj severity,is
R39 T185 T184 prep of,severity
R40 T186 T185 pobj disease,of
R41 T187 T188 advmod highly,variable
R42 T188 T168 acomp variable,is
R43 T189 T168 advcl indicating,is
R44 T190 T191 det the,influence
R45 T191 T189 dobj influence,indicating
R46 T192 T191 prep of,influence
R47 T193 T194 compound modifier,genes
R48 T194 T192 pobj genes,of
R49 T195 T168 punct .,is
R50 T197 T198 det The,intestines
R51 T198 T199 nsubj intestines,are
R52 T200 T198 prep of,intestines
R53 T201 T202 npadvmod Cftr,deficient
R54 T202 T203 amod deficient,mice
R55 T203 T200 pobj mice,of
R56 T204 T203 punct (,mice
R57 T205 T206 compound CF,mice
R58 T206 T203 appos mice,mice
R59 T207 T206 punct : ,mice
R60 T208 T206 appos Cftrtm1Unc,mice
R61 T209 T199 punct ),are
R62 T210 T199 acomp prone,are
R63 T211 T210 prep to,prone
R64 T212 T211 pobj obstruction,to
R65 T213 T212 prep by,obstruction
R66 T214 T215 amod excessive,accumulation
R67 T215 T213 pobj accumulation,by
R69 T217 T199 cc and,are
R70 T218 T219 auxpass are,used
R71 T219 T199 conj used,are
R72 T220 T219 prep as,used
R73 T221 T222 det a,model
R74 T222 T220 pobj model,as
R75 T223 T222 prep of,model
R76 T224 T225 compound meconium,ileus
R77 T225 T223 pobj ileus,of
R78 T226 T225 cc and,ileus
R80 T228 T230 compound obstruction,syndrome
R82 T230 T225 conj syndrome,ileus
R83 T231 T199 punct .,are
R84 T233 T234 det This,phenotype
R85 T234 T235 nsubj phenotype,is
R86 T236 T237 advmod strongly,dependent
R87 T237 T235 acomp dependent,is
R88 T238 T237 prep on,dependent
R89 T239 T240 det the,background
R90 T240 T238 pobj background,on
R92 T242 T240 prep of,background
R93 T243 T244 det the,mice
R94 T244 T242 pobj mice,of
R95 T245 T235 punct .,is
R96 T247 T248 prep On,survive
R97 T249 T250 det the,background
R98 T250 T247 pobj background,On
R102 T254 T248 punct ", ",survive
R103 T255 T256 det the,majority
R104 T256 T248 nsubj majority,survive
R105 T257 T256 prep of,majority
R106 T258 T259 compound CF,mice
R107 T259 T257 pobj mice,of
R108 T260 T248 aux can,survive
R109 T261 T248 neg not,survive
R110 T262 T248 prep on,survive
R111 T263 T264 amod solid,chow
R112 T264 T262 pobj chow,on
R114 T266 T248 punct ", ",survive
R115 T267 T248 conj have,survive
R116 T268 T267 dobj inflammation,have
R117 T269 T268 prep of,inflammation
R118 T270 T271 det the,intestine
R119 T271 T269 pobj intestine,of
R121 T273 T267 punct ", ",have
R122 T274 T267 cc and,have
R123 T275 T267 conj are,have
R124 T276 T277 quantmod about,30
R125 T277 T278 nummod 30,%
R126 T278 T279 npadvmod %,smaller
R127 T279 T275 acomp smaller,are
R128 T280 T279 prep than,smaller
R129 T281 T282 amod wild,type
R130 T282 T283 compound type,littermates
R131 T283 T280 pobj littermates,than
R132 T284 T248 punct .,survive
R133 T286 T287 prep In,identified
R134 T288 T289 det this,work
R135 T289 T286 pobj work,In
R136 T290 T291 compound potential,loci
R137 T291 T287 nsubjpass loci,identified
R139 T293 T291 prep of,loci
R140 T294 T295 det the,phenotype
R141 T295 T293 pobj phenotype,of
R144 T298 T287 auxpass were,identified
R145 T299 T287 punct .,identified
R146 T303 T304 compound CF,mice
R147 T304 T305 nsubjpass mice,compared
R148 T306 T304 prep on,mice
R149 T307 T308 det a,background
R150 T308 T306 pobj background,on
R153 T311 T312 punct (,C57Bl
R154 T312 T304 parataxis C57Bl,mice
R157 T315 T312 punct /,C57Bl
R158 T316 T312 nummod 6,C57Bl
R159 T317 T312 cc and,C57Bl
R160 T318 T319 nummod 5,129Sv
R161 T319 T312 conj 129Sv,C57Bl
R163 T321 T312 punct ),C57Bl
R164 T322 T305 auxpass were,compared
R165 T323 T305 prep to,compared
R166 T324 T325 compound CF,mice
R167 T325 T323 pobj mice,to
R168 T326 T325 amod congenic,mice
R169 T327 T326 prep on,congenic
R170 T328 T329 det the,background
R171 T329 T327 pobj background,on
R175 T333 T305 prep for,compared
R176 T334 T335 amod several,parameters
R177 T335 T333 pobj parameters,for
R178 T336 T335 prep of,parameters
R179 T337 T338 det the,phenotype
R180 T338 T336 pobj phenotype,of
R183 T341 T305 punct .,compared
R184 T343 T344 compound CF,mice
R185 T344 T345 nsubj mice,exhibit
R186 T346 T344 prep on,mice
R187 T347 T348 det the,background
R188 T348 T346 pobj background,on
R190 T350 T351 advmod significantly,greater
R191 T351 T352 amod greater,survival
R192 T352 T345 dobj survival,exhibit
R193 T353 T354 advmod when,fed
R194 T354 T345 advcl fed,exhibit
R195 T355 T356 amod dry,chow
R196 T356 T354 dobj chow,fed
R198 T358 T345 punct ", ",exhibit
R199 T359 T345 conj have,exhibit
R200 T360 T361 amod reduced,inflammation
R201 T361 T359 dobj inflammation,have
R203 T363 T364 mark as,measured
R204 T364 T359 advcl measured,have
R205 T365 T364 prep by,measured
R206 T366 T367 amod quantitative,PCR
R207 T367 T365 pobj PCR,by
R210 T370 T367 prep for,PCR
R211 T371 T372 compound marker,genes
R212 T372 T370 pobj genes,for
R213 T373 T359 punct ", ",have
R214 T374 T359 conj have,have
R215 T375 T376 advmod near,normal
R216 T376 T377 amod normal,gain
R217 T377 T374 dobj gain,have
R220 T380 T374 punct ", ",have
R221 T381 T374 cc and,have
R222 T382 T374 conj have,have
R223 T383 T384 amod reduced,accumulation
R224 T384 T382 dobj accumulation,have
R226 T386 T382 prep in,have
R227 T387 T388 det the,crypts
R228 T388 T386 pobj crypts,in
R230 T390 T345 punct .,exhibit
R231 T392 T393 expl There,was
R232 T393 T394 ccomp was,show
R233 T395 T396 det an,indication
R234 T396 T393 attr indication,was
R235 T397 T396 prep of,indication
R236 T398 T399 det a,effect
R237 T399 T397 pobj effect,of
R239 T401 T399 prep for,effect
R240 T402 T403 compound body,gain
R241 T403 T401 pobj gain,for
R243 T405 T394 punct : ,show
R244 T406 T394 nsubj males,show
R245 T407 T394 aux did,show
R246 T408 T394 neg not,show
R247 T409 T410 det a,improvement
R248 T410 T394 dobj improvement,show
R250 T412 T394 prep at,show
R251 T413 T414 nummod 4,weeks
R252 T414 T412 pobj weeks,at
R253 T415 T414 prep of,weeks
R254 T416 T415 pobj age,of
R255 T417 T394 punct ", ",show
R256 T418 T394 cc but,show
R257 T419 T394 conj were,show
R258 T420 T419 prep of,were
R259 T421 T422 amod normal,weight
R260 T422 T420 pobj weight,of
R261 T423 T419 prep at,were
R262 T424 T425 nummod 8,weeks
R263 T425 T423 pobj weeks,at
R264 T426 T394 punct ", ",show
R265 T427 T428 mark while,showed
R266 T428 T394 advcl showed,show
R268 T430 T428 dobj improvement,showed
R269 T431 T428 prep at,showed
R270 T432 T433 preconj both,4
R271 T433 T434 nummod 4,weeks
R272 T434 T431 pobj weeks,at
R275 T437 T394 punct .,show
R276 T439 T440 prep By,found
R277 T441 T442 det a,scanning
R278 T442 T439 pobj scanning,By
R281 T445 T442 amod wide,scanning
R282 T446 T445 punct -,wide
R285 T449 T440 punct ", ",found
R286 T450 T451 nummod three,regions
R287 T451 T440 nsubjpass regions,found
R288 T452 T440 auxpass were,found
R289 T453 T454 aux to,associated
R290 T454 T440 xcomp associated,found
R293 T457 T454 prep with,associated
R294 T458 T459 det the,phenotype
R295 T459 T457 pobj phenotype,with
R297 T461 T440 punct .,found
R298 T464 T463 prep on,One
R299 T465 T464 pobj chr.1,on
R300 T466 T463 punct ", ",One
R301 T467 T463 acl defined,One
R302 T468 T467 prep by,defined
R303 T469 T470 compound marker,D1Mit36
R304 T470 T468 pobj D1Mit36,by
R305 T471 T463 punct ", ",One
R306 T472 T463 conj one,One
R307 T473 T472 prep on,one
R308 T474 T473 pobj chr.,on
R309 T475 T474 nummod 9,chr.
R310 T476 T472 acl defined,one
R311 T477 T476 prep by,defined
R312 T478 T479 compound marker,D9Mit90
R313 T479 T477 pobj D9Mit90,by
R314 T480 T472 punct ", ",one
R315 T481 T472 cc and,one
R316 T482 T472 conj one,one
R317 T483 T482 prep on,one
R318 T484 T483 pobj chr.,on
R319 T485 T484 nummod 10,chr.
R320 T486 T482 punct ", ",one
R321 T487 T482 acl defined,one
R322 T488 T487 prep by,defined
R323 T489 T490 compound marker,D10Mit14
R324 T490 T488 pobj D10Mit14,by
R325 T491 T482 punct .,one
R326 T495 T496 amod Potential,regions
R327 T496 T498 nsubjpass regions,found
R329 T499 T498 auxpass were,found
R330 T500 T501 dep that,have
R331 T501 T498 ccomp have,found
R332 T502 T503 det a,impact
R333 T503 T501 dobj impact,have
R335 T505 T501 prep on,have
R336 T506 T507 det the,phenotype
R337 T507 T505 pobj phenotype,on
R339 T509 T507 prep of,phenotype
R340 T510 T511 det the,intestine
R341 T511 T509 pobj intestine,of
R345 T515 T507 cc and,phenotype
R346 T516 T517 compound animal,survival
R347 T517 T507 conj survival,phenotype
R348 T518 T498 punct .,found
R349 T520 T521 nsubj Identification,provide
R350 T522 T520 prep of,Identification
R351 T523 T522 pobj polymorphisms,of
R352 T524 T520 prep in,Identification
R353 T525 T526 amod specific,genes
R354 T526 T524 pobj genes,in
R355 T527 T526 prep in,genes
R356 T528 T529 det these,regions
R357 T529 T527 pobj regions,in
R358 T530 T521 aux should,provide
R359 T531 T532 amod important,information
R360 T532 T521 dobj information,provide
R362 T534 T532 prep about,information
R363 T535 T536 amod genetic,modifiers
R364 T536 T534 pobj modifiers,about
R365 T537 T536 prep of,modifiers
R366 T538 T539 det the,phenotype
R367 T539 T537 pobj phenotype,of
R370 T542 T521 punct .,provide
R371 T154 T152 punct ", ",1
R394 T802 T800 nmod conductance,regulator
R395 T803 T800 punct (,regulator
R396 T804 T800 appos CFTR,regulator
R397 T805 T797 punct ),gene
R398 T806 T807 punct [,1
R399 T807 T788 parataxis 1,caused
R400 T808 T807 punct ],1
R401 T809 T788 punct .,caused
R402 T811 T812 amod Different,mutations
R403 T812 T813 nsubj mutations,have
R404 T814 T815 det a,range
R405 T815 T813 dobj range,have
R406 T816 T815 prep of,range
R407 T817 T816 pobj effects,of
R408 T818 T817 prep on,effects
R409 T819 T820 det the,levels
R410 T820 T818 pobj levels,on
R411 T821 T820 prep of,levels
R412 T822 T823 compound CFTR,protein
R413 T823 T821 pobj protein,of
R414 T824 T820 cc and,levels
R415 T825 T826 poss its,functioning
R416 T826 T820 conj functioning,levels
R417 T827 T826 amod proper,functioning
R418 T828 T826 prep in,functioning
R419 T829 T830 amod epithelial,transport
R420 T830 T828 pobj transport,in
R421 T831 T830 prep of,transport
R422 T832 T831 pobj Cl,of
R423 T833 T832 punct -,Cl
R424 T834 T832 cc and,Cl
R425 T835 T832 conj HCO3,Cl
R426 T836 T835 punct -,HCO3
R427 T837 T838 punct [,3
R428 T838 T813 parataxis 3,have
R429 T839 T838 nummod 2,3
R430 T840 T838 punct ",",3
R431 T841 T838 punct ],3
R432 T842 T813 punct .,have
R433 T844 T845 det The,severity
R434 T845 T846 nsubj severity,is
R435 T847 T845 prep of,severity
R436 T848 T849 det the,phenotype
R437 T849 T847 pobj phenotype,of
R438 T850 T849 amod pancreatic,phenotype
R439 T851 T845 prep in,severity
R440 T852 T853 amod human,CF
R441 T853 T851 pobj CF,in
R442 T854 T855 advmod well,correlated
R443 T855 T846 acomp correlated,is
R444 T856 T855 prep with,correlated
R445 T857 T858 det the,extent
R446 T858 T856 pobj extent,with
R447 T859 T858 prep of,extent
R448 T860 T861 amod impaired,function
R449 T861 T859 pobj function,of
R450 T862 T861 compound CFTR,function
R451 T863 T861 acl caused,function
R452 T864 T863 prep by,caused
R453 T865 T866 amod specific,mutations
R454 T866 T864 pobj mutations,by
R455 T867 T846 punct .,is
R456 T869 T870 nsubj Loss,results
R457 T871 T869 prep of,Loss
R458 T872 T873 compound CFTR,function
R459 T873 T871 pobj function,of
R460 T874 T870 prep in,results
R461 T875 T874 pobj destruction,in
R462 T876 T875 prep of,destruction
R463 T877 T878 det the,tissue
R464 T878 T876 pobj tissue,of
R465 T879 T878 compound exocrine,tissue
R466 T880 T878 cc and,tissue
R467 T881 T882 amod eventual,insufficiency
R468 T882 T878 conj insufficiency,tissue
R469 T883 T882 amod pancreatic,insufficiency
R470 T884 T870 punct .,results
R471 T886 T887 prep On,is
R472 T888 T889 det the,hand
R473 T889 T886 pobj hand,On
R474 T890 T889 amod other,hand
R475 T891 T887 punct ", ",is
R476 T892 T893 det the,effects
R477 T893 T887 nsubj effects,is
R478 T894 T893 prep of,effects
R479 T895 T894 pobj CF,of
R480 T896 T893 prep on,effects
R481 T897 T896 pobj organs,on
R482 T898 T897 prep including,organs
R483 T899 T900 det the,airways
R484 T900 T898 pobj airways,including
R485 T901 T900 cc and,airways
R486 T902 T900 conj intestines,airways
R487 T903 T904 advmod less,correlated
R488 T904 T887 acomp correlated,is
R489 T905 T904 advmod well,correlated
R490 T906 T904 prep with,correlated
R491 T907 T908 amod specific,mutations
R492 T908 T906 pobj mutations,with
R493 T909 T908 compound CFTR,mutations
R494 T910 T908 cc and,mutations
R495 T911 T912 poss their,effects
R496 T912 T908 conj effects,mutations
R497 T913 T912 prep on,effects
R498 T914 T915 compound CFTR,function
R499 T915 T913 pobj function,on
R500 T916 T915 compound protein,function
R501 T917 T918 punct [,4
R502 T918 T887 parataxis 4,is
R503 T919 T920 punct -,8
R504 T920 T918 prep 8,4
R505 T921 T918 punct ],4
R506 T922 T887 punct .,is
R507 T924 T925 nsubj This,indicates
R508 T926 T927 mark that,are
R509 T927 T925 ccomp are,indicates
R510 T928 T929 amod other,genes
R511 T929 T927 nsubj genes,are
R512 T930 T927 acomp likely,are
R513 T931 T932 aux to,be
R514 T932 T930 xcomp be,likely
R515 T933 T932 acomp important,be
R516 T934 T932 prep as,be
R517 T935 T934 pobj modifiers,as
R518 T936 T935 prep of,modifiers
R519 T937 T938 det the,phenotype
R520 T938 T936 pobj phenotype,of
R521 T939 T938 compound CF,phenotype
R522 T940 T925 punct .,indicates
R523 T942 T943 prep With,are
R524 T944 T945 det the,exception
R525 T945 T942 pobj exception,With
R526 T946 T945 prep of,exception
R527 T947 T948 amod pancreatic,insufficiency
R528 T948 T949 nsubj insufficiency,resulting
R529 T949 T946 pcomp resulting,of
R530 T950 T949 prep in,resulting
R531 T951 T952 amod impaired,digestion
R532 T952 T950 pobj digestion,in
R533 T953 T943 punct ", ",are
R534 T954 T955 amod other,aspects
R535 T955 T943 nsubj aspects,are
R536 T956 T955 prep of,aspects
R537 T957 T956 pobj CF,of
R538 T958 T959 advmod less,readily
R539 T959 T960 advmod readily,related
R540 T960 T943 acomp related,are
R541 T961 T960 prep to,related
R542 T962 T961 pobj loss,to
R543 T963 T962 prep of,loss
R544 T964 T965 compound CFTR,function
R545 T965 T963 pobj function,of
R546 T966 T943 punct .,are
R547 T968 T969 amod Nutritional,problems
R548 T969 T970 nsubj problems,persist
R549 T971 T970 aux can,persist
R550 T972 T973 advmod even,with
R551 T973 T970 prep with,persist
R552 T974 T975 amod adequate,supplementation
R553 T975 T973 pobj supplementation,with
R554 T976 T977 amod oral,enzyme
R555 T977 T975 compound enzyme,supplementation
R556 T978 T979 punct [,9
R557 T979 T975 parataxis 9,supplementation
R558 T980 T979 punct ],9
R559 T981 T975 cc and,supplementation
R560 T982 T975 conj neutralization,supplementation
R561 T983 T982 prep of,neutralization
R562 T984 T985 amod gastric,acid
R563 T985 T983 pobj acid,of
R564 T986 T987 aux to,improve
R565 T987 T982 advcl improve,neutralization
R566 T988 T987 dep lipase,improve
R567 T989 T987 dep function,improve
R568 T990 T991 punct [,10
R569 T991 T982 parataxis 10,neutralization
R570 T992 T991 punct ],10
R571 T993 T970 punct ", ",persist
R572 T994 T970 cc and,persist
R573 T995 T996 aux may,involve
R574 T996 T970 conj involve,persist
R575 T997 T998 preconj both,digestion
R576 T998 T996 dobj digestion,involve
R577 T999 T998 amod impaired,digestion
R578 T1000 T998 cc and,digestion
R579 T1001 T998 conj absorption,digestion
R580 T1002 T998 prep of,digestion
R581 T1003 T1002 pobj nutrients,of
R582 T1004 T1005 punct [,11
R583 T1005 T996 parataxis 11,involve
R584 T1006 T1005 punct ],11
R585 T1007 T970 punct .,persist
R586 T1009 T1010 amod Inadequate,absorption
R587 T1010 T1011 nsubj absorption,appears
R588 T1012 T1010 cc or,absorption
R589 T1013 T1010 conj assimilation,absorption
R590 T1014 T1010 prep of,absorption
R591 T1015 T1014 pobj nutrients,of
R592 T1016 T1017 aux to,be
R593 T1017 T1011 xcomp be,appears
R594 T1018 T1017 prep of,be
R595 T1019 T1020 amod greater,importance
R596 T1020 T1018 pobj importance,of
R597 T1021 T1022 mark because,corrected
R598 T1022 T1011 advcl corrected,appears
R599 T1023 T1024 advmod even,with
R600 T1024 T1022 prep with,corrected
R601 T1025 T1026 amod adequate,supplementation
R602 T1026 T1024 pobj supplementation,with
R603 T1027 T1028 amod oral,enzyme
R604 T1028 T1026 compound enzyme,supplementation
R605 T1029 T1022 nsubjpass nutrition,corrected
R606 T1030 T1022 auxpass is,corrected
R607 T1031 T1022 advmod rarely,corrected
R608 T1032 T1022 advmod fully,corrected
R609 T1033 T1034 punct [,11
R610 T1034 T1011 parataxis 11,appears
R611 T1035 T1034 punct ],11
R612 T1036 T1011 punct .,appears
R613 T1038 T1039 expl There,is
R614 T1040 T1039 advmod also,is
R615 T1041 T1042 amod excessive,accumulation
R616 T1042 T1039 attr accumulation,is
R617 T1043 T1042 compound mucus,accumulation
R618 T1044 T1039 prep in,is
R619 T1045 T1046 det the,intestine
R620 T1046 T1044 pobj intestine,in
R621 T1047 T1046 compound CF,intestine
R622 T1048 T1039 punct ", ",is
R623 T1049 T1039 cc and,is
R624 T1050 T1051 amod inappropriate,inflammation
R625 T1051 T1052 nsubj inflammation,is
R626 T1052 T1039 conj is,is
R627 T1053 T1052 acomp common,is
R628 T1054 T1055 punct [,12
R629 T1055 T1052 parataxis 12,is
R630 T1056 T1055 punct ],12
R631 T1057 T1052 punct .,is
R632 T1059 T1060 nsubjpass Mucus,involved
R633 T1061 T1060 auxpass is,involved
R634 T1062 T1060 prep in,involved
R635 T1063 T1062 pobj obstruction,in
R636 T1064 T1063 prep of,obstruction
R637 T1065 T1066 det the,gut
R638 T1066 T1064 pobj gut,of
R639 T1067 T1068 dep which,occurs
R640 T1068 T1063 relcl occurs,obstruction
R641 T1069 T1068 advmod frequently,occurs
R642 T1070 T1068 prep in,occurs
R643 T1071 T1072 compound CF,infants
R644 T1072 T1070 pobj infants,in
R645 T1073 T1072 punct (,infants
R646 T1074 T1072 acl called,infants
R647 T1075 T1076 compound meconium,ileus
R648 T1076 T1074 oprd ileus,called
R649 T1077 T1076 punct ", ",ileus
R650 T1078 T1076 appos MI,ileus
R651 T1079 T1072 punct ),infants
R652 T1080 T1072 cc and,infants
R653 T1081 T1072 conj adults,infants
R654 T1082 T1081 punct (,adults
R655 T1083 T1081 acl called,adults
R656 T1084 T1085 amod distal,syndrome
R657 T1085 T1083 oprd syndrome,called
R658 T1086 T1085 amod intestinal,syndrome
R659 T1087 T1085 compound obstruction,syndrome
R660 T1088 T1085 punct ", ",syndrome
R661 T1089 T1085 appos DIOS,syndrome
R662 T1090 T1060 punct ),involved
R663 T1091 T1092 punct [,13
R664 T1092 T1060 parataxis 13,involved
R665 T1093 T1092 nummod 11,13
R666 T1094 T1092 punct ",",13
R667 T1095 T1092 punct ],13
R668 T1096 T1060 punct .,involved
R669 T1098 T1099 cc And,is
R670 T1100 T1099 punct ", ",is
R671 T1101 T1099 advcl similar,is
R672 T1102 T1101 prep to,similar
R673 T1103 T1104 compound CF,airways
R674 T1104 T1102 pobj airways,to
R675 T1105 T1099 punct ", ",is
R676 T1106 T1099 expl there,is
R677 T1107 T1099 advmod also,is
R678 T1108 T1109 det an,inflammation
R679 T1109 T1099 attr inflammation,is
R680 T1110 T1109 prep of,inflammation
R681 T1111 T1112 det the,intestines
R682 T1112 T1110 pobj intestines,of
R683 T1113 T1112 compound CF,intestines
R684 T1114 T1115 punct [,15
R685 T1115 T1099 parataxis 15,is
R686 T1116 T1115 nummod 14,15
R687 T1117 T1115 punct ",",15
R688 T1118 T1115 punct ],15
R689 T1119 T1099 punct .,is
R690 T1121 T1122 det These,changes
R691 T1122 T1123 nsubj changes,are
R692 T1124 T1125 advmod less,directly
R693 T1125 T1126 advmod directly,related
R694 T1126 T1123 acomp related,are
R695 T1127 T1126 prep to,related
R696 T1128 T1129 amod specific,mutations
R697 T1129 T1127 pobj mutations,to
R698 T1130 T1129 prep in,mutations
R699 T1131 T1132 det the,gene
R700 T1132 T1130 pobj gene,in
R701 T1133 T1132 compound CFTR,gene
R702 T1134 T1123 cc and,are
R703 T1135 T1123 conj are,are
R704 T1136 T1135 advmod likely,are
R705 T1137 T1135 acomp related,are
R706 T1138 T1137 prep to,related
R707 T1139 T1140 amod other,differences
R708 T1140 T1138 pobj differences,to
R709 T1141 T1140 prep in,differences
R710 T1142 T1143 amod individual,makeup
R711 T1143 T1141 pobj makeup,in
R712 T1144 T1143 amod genetic,makeup
R713 T1145 T1123 punct .,are
R714 T1147 T1148 amod Previous,work
R715 T1148 T1149 nsubj work,identified
R716 T1150 T1148 acl using,work
R717 T1151 T1152 amod human,patients
R718 T1152 T1150 dobj patients,using
R719 T1153 T1152 cc and,patients
R720 T1154 T1155 advmod genetically,altered
R721 T1155 T1156 amod altered,mice
R722 T1156 T1152 conj mice,patients
R723 T1157 T1149 aux has,identified
R724 T1158 T1159 det some,genes
R725 T1159 T1149 dobj genes,identified
R726 T1160 T1159 compound modifier,genes
R727 T1161 T1149 cc and,identified
R728 T1162 T1163 aux have,advanced
R729 T1163 T1149 conj advanced,identified
R730 T1164 T1165 poss our,understanding
R731 T1165 T1163 dobj understanding,advanced
R732 T1166 T1165 prep of,understanding
R733 T1167 T1168 compound CF,pathophysiology
R734 T1168 T1166 pobj pathophysiology,of
R735 T1169 T1170 punct [,4
R736 T1170 T1163 parataxis 4,advanced
R737 T1171 T1170 punct ],4
R738 T1172 T1149 punct .,identified
R739 T1174 T1175 prep In,shown
R740 T1176 T1177 nummod one,study
R741 T1177 T1174 pobj study,In
R742 T1178 T1177 acl using,study
R743 T1179 T1180 compound CF,mice
R744 T1180 T1178 dobj mice,using
R745 T1181 T1180 prep on,mice
R746 T1182 T1183 amod different,backgrounds
R747 T1183 T1181 pobj backgrounds,on
R748 T1184 T1183 amod genetic,backgrounds
R749 T1185 T1175 punct ", ",shown
R750 T1186 T1187 det a,region
R751 T1187 T1175 nsubjpass region,shown
R752 T1188 T1187 prep on,region
R753 T1189 T1190 compound mouse,chromosome
R754 T1190 T1188 pobj chromosome,on
R755 T1191 T1190 nummod 7,chromosome
R756 T1192 T1175 auxpass was,shown
R757 T1193 T1194 aux to,ameliorate
R758 T1194 T1175 xcomp ameliorate,shown
R759 T1195 T1196 amod intestinal,blockage
R760 T1196 T1194 dobj blockage,ameliorate
R761 T1197 T1175 cc and,shown
R762 T1198 T1199 det the,effect
R763 T1199 T1200 nsubj effect,was
R764 T1200 T1175 conj was,shown
R765 T1201 T1200 prep in,was
R766 T1202 T1201 amod part,in
R767 T1203 T1200 prep due,was
R768 T1204 T1203 pcomp to,due
R769 T1205 T1206 det a,channel
R770 T1206 T1203 pobj channel,due
R771 T1207 T1208 npadvmod calcium,regulated
R772 T1208 T1206 amod regulated,channel
R773 T1209 T1208 punct -,regulated
R774 T1210 T1206 nmod Cl,channel
R775 T1211 T1206 punct -,channel
R776 T1212 T1213 dep which,compensated
R777 T1213 T1206 relcl compensated,channel
R778 T1214 T1213 prep for,compensated
R779 T1215 T1214 pobj loss,for
R780 T1216 T1215 prep of,loss
R781 T1217 T1218 compound CFTR,function
R782 T1218 T1216 pobj function,of
R783 T1219 T1220 punct [,17
R784 T1220 T1200 parataxis 17,was
R785 T1221 T1220 nummod 16,17
R786 T1222 T1220 punct ",",17
R787 T1223 T1220 punct ],17
R788 T1224 T1200 punct .,was
R789 T1226 T1227 compound Marker,haplotypes
R790 T1227 T1228 nsubjpass haplotypes,shown
R791 T1229 T1227 prep of,haplotypes
R792 T1230 T1231 det the,region
R793 T1231 T1229 pobj region,of
R794 T1232 T1231 amod syntenic,region
R795 T1233 T1231 prep of,region
R796 T1234 T1235 amod human,chromosome
R797 T1235 T1233 pobj chromosome,of
R798 T1236 T1235 nummod 19q13,chromosome
R799 T1237 T1228 auxpass were,shown
R800 T1238 T1228 advmod also,shown
R801 T1239 T1240 aux to,associated
R802 T1240 T1228 xcomp associated,shown
R803 T1241 T1240 auxpass be,associated
R804 T1242 T1240 prep with,associated
R805 T1243 T1244 det the,risk
R806 T1244 T1242 pobj risk,with
R807 T1245 T1244 prep of,risk
R808 T1246 T1245 pobj MI,of
R809 T1247 T1240 prep in,associated
R810 T1248 T1249 compound CF,patients
R811 T1249 T1247 pobj patients,in
R812 T1250 T1251 punct [,18
R813 T1251 T1228 parataxis 18,shown
R814 T1252 T1251 punct ],18
R815 T1253 T1228 punct .,shown
R816 T1255 T1256 prep In,associated
R817 T1257 T1258 amod other,work
R818 T1258 T1255 pobj work,In
R819 T1259 T1256 punct ", ",associated
R820 T1260 T1261 det a,region
R821 T1261 T1256 nsubjpass region,associated
R822 T1262 T1261 prep on,region
R823 T1263 T1264 compound mouse,chr.
R824 T1264 T1262 pobj chr.,on
R825 T1265 T1264 nummod 6,chr.
R826 T1266 T1256 auxpass was,associated
R827 T1267 T1256 advmod strongly,associated
R828 T1268 T1256 prep with,associated
R829 T1269 T1270 compound lung,inflammation
R830 T1270 T1268 pobj inflammation,with
R831 T1271 T1270 punct ", ",inflammation
R832 T1272 T1270 acl consisting,inflammation
R833 T1273 T1272 prep of,consisting
R834 T1274 T1275 amod mononuclear,cell
R835 T1275 T1276 nmod cell,infiltration
R836 T1276 T1273 pobj infiltration,of
R837 T1277 T1276 amod interstitial,infiltration
R838 T1278 T1276 cc and,infiltration
R839 T1279 T1276 conj fibrosis,infiltration
R840 T1280 T1272 prep in,consisting
R841 T1281 T1282 compound CF,airways
R842 T1282 T1280 pobj airways,in
R843 T1283 T1282 compound mouse,airways
R844 T1284 T1256 punct ;,associated
R845 T1285 T1256 cc and,associated
R846 T1286 T1287 amod other,loci
R847 T1287 T1288 nsubjpass loci,linked
R848 T1288 T1256 conj linked,associated
R849 T1289 T1287 prep on,loci
R850 T1290 T1291 nmod chr.,1
R851 T1291 T1289 pobj 1,on
R852 T1292 T1291 punct ", ",1
R853 T1293 T1291 conj 2,1
R854 T1294 T1293 punct ", ",2
R855 T1295 T1293 conj 10,2
R856 T1296 T1295 punct ", ",10
R857 T1297 T1295 cc and,10
R858 T1298 T1295 conj 17,10
R859 T1299 T1288 auxpass were,linked
R860 T1300 T1288 advmod also,linked
R861 T1301 T1288 prep to,linked
R862 T1302 T1303 det the,phenotype
R863 T1303 T1301 pobj phenotype,to
R864 T1304 T1303 compound airway,phenotype
R865 T1305 T1306 punct [,19
R866 T1306 T1288 parataxis 19,linked
R867 T1307 T1306 punct ],19
R868 T1308 T1256 punct .,associated
R869 T1310 T1311 prep In,found
R870 T1312 T1313 det this,work
R871 T1313 T1310 pobj work,In
R872 T1314 T1311 punct ", ",found
R873 T1315 T1316 compound CF,mice
R874 T1316 T1311 nsubjpass mice,found
R875 T1317 T1316 prep on,mice
R876 T1318 T1319 det a,background
R877 T1319 T1317 pobj background,on
R878 T1320 T1321 amod mixed,strain
R879 T1321 T1319 compound strain,background
R880 T1322 T1311 auxpass were,found
R881 T1323 T1324 aux to,have
R882 T1324 T1311 xcomp have,found
R883 T1325 T1326 det a,phenotype
R884 T1326 T1324 dobj phenotype,have
R885 T1327 T1328 advmod less,severe
R886 T1328 T1326 amod severe,phenotype
R887 T1329 T1326 compound CF,phenotype
R888 T1330 T1324 prep compared,have
R889 T1331 T1330 prep to,compared
R890 T1332 T1333 compound CF,mice
R891 T1333 T1331 pobj mice,to
R892 T1334 T1333 amod congenic,mice
R893 T1335 T1334 prep on,congenic
R894 T1336 T1337 det the,background
R895 T1337 T1335 pobj background,on
R896 T1338 T1337 nmod C57Bl,background
R897 T1339 T1338 punct /,C57Bl
R898 T1340 T1338 nummod 6,C57Bl
R899 T1341 T1311 punct .,found
R900 T1343 T1344 expl There,were
R901 T1345 T1346 det no,differences
R902 T1346 T1344 attr differences,were
R903 T1347 T1346 prep in,differences
R904 T1348 T1349 det the,phenotype
R905 T1349 T1347 pobj phenotype,in
R906 T1350 T1349 amod pancreatic,phenotype
R907 T1351 T1344 advcl comparing,were
R908 T1352 T1353 compound CF,mice
R909 T1353 T1351 dobj mice,comparing
R910 T1354 T1351 prep on,comparing
R911 T1355 T1356 det the,backgrounds
R912 T1356 T1354 pobj backgrounds,on
R913 T1357 T1356 amod different,backgrounds
R914 T1358 T1359 punct [,20
R915 T1359 T1344 parataxis 20,were
R916 T1360 T1359 punct ],20
R917 T1361 T1344 punct .,were
R918 T1363 T1364 advmod However,seemed
R919 T1365 T1364 punct ", ",seemed
R920 T1366 T1364 nsubj mice,seemed
R921 T1367 T1366 prep on,mice
R922 T1368 T1369 det the,background
R923 T1369 T1367 pobj background,on
R924 T1370 T1369 amod mixed,background
R925 T1371 T1372 advmod more,robust
R926 T1372 T1364 oprd robust,seemed
R927 T1373 T1372 prep than,robust
R928 T1374 T1375 compound CF,mice
R929 T1375 T1373 pobj mice,than
R930 T1376 T1375 prep on,mice
R931 T1377 T1378 det the,background
R932 T1378 T1376 pobj background,on
R933 T1379 T1378 compound B6,background
R934 T1380 T1381 dep which,prompted
R935 T1381 T1364 advcl prompted,seemed
R936 T1382 T1381 dobj us,prompted
R937 T1383 T1384 aux to,characterize
R938 T1384 T1381 xcomp characterize,prompted
R939 T1385 T1384 dobj them,characterize
R940 T1386 T1384 prep in,characterize
R941 T1387 T1388 amod greater,detail
R942 T1388 T1386 pobj detail,in
R943 T1389 T1364 punct .,seemed
R944 T1391 T1392 npadvmod Genome,wide
R945 T1392 T1393 amod wide,scanning
R946 T1393 T1395 nsubjpass scanning,used
R947 T1394 T1393 compound allele,scanning
R948 T1396 T1395 auxpass was,used
R949 T1397 T1398 aux to,begin
R950 T1398 T1395 xcomp begin,used
R951 T1399 T1398 dobj identification,begin
R952 T1400 T1399 prep of,identification
R953 T1401 T1400 pobj regions,of
R954 T1402 T1401 acl associated,regions
R955 T1403 T1402 prep with,associated
R956 T1404 T1405 det the,phenotype
R957 T1405 T1403 pobj phenotype,with
R958 T1406 T1407 advmod less,severe
R959 T1407 T1405 amod severe,phenotype
R960 T1408 T1405 amod intestinal,phenotype
R961 T1409 T1395 punct .,used
R962 T1411 T1412 amod Future,identification
R963 T1412 T1413 nsubj identification,further
R964 T1414 T1412 prep of,identification
R965 T1415 T1416 amod specific,genes
R966 T1416 T1414 pobj genes,of
R967 T1417 T1413 aux should,further
R968 T1418 T1419 poss our,understanding
R969 T1419 T1413 dobj understanding,further
R970 T1420 T1419 prep of,understanding
R971 T1421 T1422 det the,phenotype
R972 T1422 T1420 pobj phenotype,of
R973 T1423 T1422 amod complex,phenotype
R974 T1424 T1422 amod intestinal,phenotype
R975 T1425 T1422 compound CF,phenotype
R976 T1426 T1413 punct .,further
R977 T1472 T1473 compound CF,mice
R978 T1473 T1474 nsubj mice,have
R979 T1475 T1473 prep on,mice
R980 T1476 T1477 det the,background
R981 T1477 T1475 pobj background,on
R982 T1478 T1477 amod mixed,background
R983 T1479 T1480 amod improved,gain
R984 T1480 T1474 dobj gain,have
R985 T1481 T1480 compound body,gain
R986 T1482 T1480 compound weight,gain
R987 T1484 T1485 compound Body,mass
R988 T1485 T1486 nsubjpass mass,recorded
R989 T1487 T1486 auxpass was,recorded
R990 T1488 T1486 prep for,recorded
R991 T1489 T1490 amod male,mice
R992 T1490 T1488 pobj mice,for
R993 T1491 T1489 cc and,male
R994 T1492 T1489 conj female,male
R995 T1493 T1486 prep at,recorded
R996 T1494 T1495 nummod 4,weeks
R997 T1495 T1493 pobj weeks,at
R998 T1496 T1494 cc and,4
R999 T1497 T1494 conj 8,4
R1000 T1498 T1495 prep of,weeks
R1001 T1499 T1498 pobj age,of
R1002 T1500 T1486 punct .,recorded
R1003 T1502 T1503 prep On,are
R1004 T1504 T1505 det the,background
R1005 T1505 T1502 pobj background,On
R1006 T1506 T1505 compound B6,background
R1007 T1507 T1503 punct ", ",are
R1008 T1508 T1509 amod female,mice
R1009 T1509 T1503 nsubj mice,are
R1010 T1510 T1508 cc and,female
R1011 T1511 T1508 conj male,female
R1012 T1512 T1513 quantmod about,30
R1013 T1513 T1514 nummod 30,%
R1014 T1514 T1515 npadvmod %,smaller
R1015 T1515 T1503 acomp smaller,are
R1016 T1516 T1515 prep than,smaller
R1017 T1517 T1518 amod wild,type
R1018 T1518 T1519 compound type,mice
R1019 T1519 T1516 pobj mice,than
R1020 T1520 T1503 prep at,are
R1021 T1521 T1522 preconj both,4
R1022 T1522 T1523 nummod 4,weeks
R1023 T1523 T1520 pobj weeks,at
R1024 T1524 T1522 cc and,4
R1025 T1525 T1522 conj 8,4
R1026 T1526 T1523 prep of,weeks
R1027 T1527 T1526 pobj age,of
R1028 T1528 T1529 punct (,B
R1029 T1529 T1503 parataxis B,are
R1030 T1530 T1529 nmod Fig.,B
R1031 T1531 T1529 nummod 1A,B
R1032 T1532 T1529 punct ", ",B
R1033 T1533 T1529 punct ),B
R1034 T1534 T1503 punct .,are
R1035 T1536 T1537 prep By,were
R1036 T1538 T1536 pobj comparison,By
R1037 T1539 T1537 punct ", ",were
R1038 T1540 T1541 amod female,mice
R1039 T1541 T1537 nsubj mice,were
R1040 T1542 T1541 compound CF,mice
R1041 T1543 T1541 prep on,mice
R1042 T1544 T1545 det the,background
R1043 T1545 T1543 pobj background,on
R1044 T1546 T1545 amod mixed,background
R1045 T1547 T1537 neg not,were
R1046 T1548 T1549 advmod significantly,smaller
R1047 T1549 T1537 acomp smaller,were
R1048 T1550 T1549 prep than,smaller
R1049 T1551 T1552 amod wild,type
R1050 T1552 T1553 compound type,mice
R1051 T1553 T1550 pobj mice,than
R1052 T1554 T1537 prep at,were
R1053 T1555 T1556 nummod 4,weeks
R1054 T1556 T1554 pobj weeks,at
R1055 T1557 T1556 prep of,weeks
R1056 T1558 T1557 pobj age,of
R1057 T1559 T1560 punct (,Fig.
R1058 T1560 T1537 parataxis Fig.,were
R1059 T1561 T1560 nummod 1A,Fig.
R1060 T1562 T1560 punct ),Fig.
R1061 T1563 T1537 punct .,were
R1062 T1565 T1566 det The,weight
R1063 T1566 T1569 nsubjpass weight,maintained
R1064 T1567 T1566 amod improved,weight
R1065 T1568 T1566 compound body,weight
R1066 T1570 T1566 prep of,weight
R1067 T1571 T1572 amod female,mice
R1068 T1572 T1570 pobj mice,of
R1069 T1573 T1572 compound CF,mice
R1070 T1574 T1572 prep on,mice
R1071 T1575 T1576 det the,background
R1072 T1576 T1574 pobj background,on
R1073 T1577 T1576 amod mixed,background
R1074 T1578 T1569 auxpass was,maintained
R1075 T1579 T1569 prep at,maintained
R1076 T1580 T1581 nummod 8,weeks
R1077 T1581 T1579 pobj weeks,at
R1078 T1582 T1581 prep of,weeks
R1079 T1583 T1582 pobj age,of
R1080 T1584 T1569 punct .,maintained
R1081 T1586 T1587 amod Male,mice
R1082 T1587 T1589 nsubj mice,were
R1083 T1588 T1587 compound CF,mice
R1084 T1590 T1587 prep on,mice
R1085 T1591 T1592 det the,background
R1086 T1592 T1590 pobj background,on
R1087 T1593 T1592 amod mixed,background
R1088 T1594 T1589 prep at,were
R1089 T1595 T1596 nummod 4,weeks
R1090 T1596 T1594 pobj weeks,at
R1091 T1597 T1596 prep of,weeks
R1092 T1598 T1597 pobj age,of
R1093 T1599 T1600 advmod significantly,smaller
R1094 T1600 T1589 acomp smaller,were
R1095 T1601 T1600 prep than,smaller
R1096 T1602 T1603 amod wild,type
R1097 T1603 T1601 pobj type,than
R1098 T1604 T1600 cc and,smaller
R1099 T1605 T1604 neg not,and
R1100 T1606 T1607 advmod significantly,larger
R1101 T1607 T1600 conj larger,smaller
R1102 T1608 T1607 prep than,larger
R1103 T1609 T1610 compound CF,mice
R1104 T1610 T1608 pobj mice,than
R1105 T1611 T1610 amod congenic,mice
R1106 T1612 T1611 prep on,congenic
R1107 T1613 T1614 det the,background
R1108 T1614 T1612 pobj background,on
R1109 T1615 T1614 compound B6,background
R1110 T1616 T1617 punct (,Fig.
R1111 T1617 T1589 parataxis Fig.,were
R1112 T1618 T1617 nummod 1B,Fig.
R1113 T1619 T1617 punct ),Fig.
R1114 T1620 T1589 punct .,were
R1115 T1622 T1623 prep By,were
R1116 T1624 T1625 nummod 8,weeks
R1117 T1625 T1622 pobj weeks,By
R1118 T1626 T1625 prep of,weeks
R1119 T1627 T1626 pobj age,of
R1120 T1628 T1623 punct ", ",were
R1121 T1629 T1630 compound CF,males
R1122 T1630 T1623 nsubj males,were
R1123 T1631 T1630 prep on,males
R1124 T1632 T1633 det the,background
R1125 T1633 T1631 pobj background,on
R1126 T1634 T1633 amod mixed,background
R1127 T1635 T1636 nummod 12,%
R1128 T1636 T1637 npadvmod %,smaller
R1129 T1637 T1623 acomp smaller,were
R1130 T1638 T1623 cc but,were
R1131 T1639 T1640 nsubj this,was
R1132 T1640 T1623 conj was,were
R1133 T1641 T1640 neg not,was
R1134 T1642 T1643 advmod significantly,different
R1135 T1643 T1640 acomp different,was
R1136 T1644 T1640 prep compared,was
R1137 T1645 T1644 prep to,compared
R1138 T1646 T1647 amod wild,type
R1139 T1647 T1648 compound type,mice
R1140 T1648 T1645 pobj mice,to
R1141 T1649 T1650 punct (,Fig.
R1142 T1650 T1640 parataxis Fig.,was
R1143 T1651 T1650 nummod 1B,Fig.
R1144 T1652 T1650 punct ),Fig.
R1145 T1653 T1640 punct .,was
R1146 T1974 T1975 compound CF,mice
R1147 T1975 T1976 nsubj mice,have
R1148 T1977 T1975 prep on,mice
R1149 T1978 T1979 det the,background
R1150 T1979 T1977 pobj background,on
R1151 T1980 T1979 amod mixed,background
R1152 T1981 T1982 amod reduced,expression
R1153 T1982 T1976 dobj expression,have
R1154 T1983 T1982 prep of,expression
R1155 T1984 T1985 amod inflammatory,markers
R1156 T1985 T1983 pobj markers,of
R1157 T1987 T1988 amod Previous,work
R1158 T1988 T1989 nsubj work,showed
R1159 T1990 T1991 mark that,have
R1160 T1991 T1989 ccomp have,showed
R1161 T1992 T1993 compound CF,mice
R1162 T1993 T1991 nsubj mice,have
R1163 T1994 T1993 prep on,mice
R1164 T1995 T1996 det the,background
R1165 T1996 T1994 pobj background,on
R1166 T1997 T1996 compound B6,background
R1167 T1998 T1999 det an,inflammation
R1168 T1999 T1991 dobj inflammation,have
R1169 T2000 T2001 amod innate,type
R1170 T2001 T1999 compound type,inflammation
R1171 T2002 T2001 punct -,type
R1172 T2003 T1999 prep of,inflammation
R1173 T2004 T2005 det the,intestine
R1174 T2005 T2003 pobj intestine,of
R1175 T2006 T2005 amod small,intestine
R1176 T2007 T2008 punct [,21
R1177 T2008 T1989 parataxis 21,showed
R1178 T2009 T2008 punct ],21
R1179 T2010 T1989 punct .,showed
R1180 T2012 T2013 aux To,determine
R1181 T2013 T2014 advcl determine,used
R1182 T2015 T2016 mark whether,affected
R1183 T2016 T2013 ccomp affected,determine
R1184 T2017 T2018 det the,background
R1185 T2018 T2016 nsubj background,affected
R1186 T2019 T2018 amod mixed,background
R1187 T2020 T2018 amod genetic,background
R1188 T2021 T2016 dobj expression,affected
R1189 T2022 T2021 prep of,expression
R1190 T2023 T2024 amod inflammatory,genes
R1191 T2024 T2022 pobj genes,of
R1192 T2025 T2024 compound marker,genes
R1193 T2026 T2014 punct ", ",used
R1194 T2027 T2028 amod quantitative,PCR
R1195 T2028 T2014 nsubjpass PCR,used
R1196 T2029 T2028 punct ", ",PCR
R1197 T2030 T2031 amod real,time
R1198 T2031 T2028 compound time,PCR
R1199 T2032 T2031 punct -,time
R1200 T2033 T2028 compound RT,PCR
R1201 T2034 T2028 punct -,PCR
R1202 T2035 T2014 auxpass was,used
R1203 T2036 T2037 aux to,measure
R1204 T2037 T2014 advcl measure,used
R1205 T2038 T2039 compound gene,expression
R1206 T2039 T2037 dobj expression,measure
R1207 T2040 T2014 punct .,used
R1208 T2042 T2043 nsubjpass Expression,compared
R1209 T2044 T2042 prep of,Expression
R1210 T2045 T2046 det the,genes
R1211 T2046 T2044 pobj genes,of
R1212 T2047 T2046 amod following,genes
R1213 T2048 T2043 auxpass was,compared
R1214 T2049 T2043 prep in,compared
R1215 T2050 T2051 amod wild,type
R1216 T2051 T2052 nmod type,mice
R1217 T2052 T2049 pobj mice,in
R1218 T2053 T2051 cc and,type
R1219 T2054 T2051 conj CF,type
R1220 T2055 T2052 prep on,mice
R1221 T2056 T2057 det the,backgrounds
R1222 T2057 T2055 pobj backgrounds,on
R1223 T2058 T2057 amod different,backgrounds
R1224 T2059 T2057 amod genetic,backgrounds
R1225 T2060 T2043 punct .,compared
R1226 T2062 T2063 compound Mast,protease
R1227 T2063 T2065 nsubj protease,is
R1228 T2064 T2063 compound cell,protease
R1229 T2066 T2063 nummod 2,protease
R1230 T2067 T2063 punct (,protease
R1231 T2068 T2063 appos Mcpt2,protease
R1232 T2069 T2065 punct ),is
R1233 T2070 T2071 det a,marker
R1234 T2071 T2065 attr marker,is
R1235 T2072 T2071 prep of,marker
R1236 T2073 T2074 amod differentiated,cells
R1237 T2074 T2072 pobj cells,of
R1238 T2075 T2074 compound mast,cells
R1239 T2076 T2077 punct [,22
R1240 T2077 T2065 parataxis 22,is
R1241 T2078 T2077 punct ],22
R1242 T2079 T2065 cc and,is
R1243 T2080 T2081 compound mast,cells
R1244 T2081 T2082 nsubj cells,are
R1245 T2082 T2065 conj are,is
R1246 T2083 T2084 advmod more,abundant
R1247 T2084 T2082 acomp abundant,are
R1248 T2085 T2082 prep in,are
R1249 T2086 T2087 det the,intestine
R1250 T2087 T2085 pobj intestine,in
R1251 T2088 T2087 compound B6,intestine
R1252 T2089 T2087 compound CF,intestine
R1253 T2090 T2087 compound mouse,intestine
R1254 T2091 T2082 punct .,are
R1255 T2093 T2094 nmod Leucine,glycoprotein
R1256 T2094 T2098 nsubj glycoprotein,is
R1257 T2095 T2093 punct -,Leucine
R1258 T2096 T2093 amod rich,Leucine
R1259 T2097 T2094 compound α2,glycoprotein
R1260 T2099 T2094 punct (,glycoprotein
R1261 T2100 T2094 appos Lrg1,glycoprotein
R1262 T2101 T2094 punct ", ",glycoprotein
R1263 T2102 T2103 punct [,23
R1264 T2103 T2094 parataxis 23,glycoprotein
R1265 T2104 T2103 punct ],23
R1266 T2105 T2098 punct ),is
R1267 T2106 T2107 det a,marker
R1268 T2107 T2098 attr marker,is
R1269 T2108 T2107 prep of,marker
R1270 T2109 T2110 amod differentiating,neutrophils
R1271 T2110 T2108 pobj neutrophils,of
R1272 T2111 T2110 punct ", ",neutrophils
R1273 T2112 T2113 dep which,are
R1274 T2113 T2110 relcl are,neutrophils
R1275 T2114 T2115 advmod more,numerous
R1276 T2115 T2113 acomp numerous,are
R1277 T2116 T2113 prep in,are
R1278 T2117 T2118 det the,intestine
R1279 T2118 T2116 pobj intestine,in
R1280 T2119 T2120 compound B6,mouse
R1281 T2120 T2118 compound mouse,intestine
R1282 T2121 T2120 compound CF,mouse
R1283 T2122 T2098 punct .,is
R1284 T2124 T2125 det The,gene
R1285 T2125 T2127 nsubjpass gene,known
R1286 T2126 T2125 amod same,gene
R1287 T2128 T2127 auxpass is,known
R1288 T2129 T2127 advmod also,known
R1289 T2130 T2127 prep as,known
R1290 T2131 T2132 npadvmod leucine,rich
R1291 T2132 T2134 amod rich,glycoprotein
R1292 T2133 T2132 punct -,rich
R1293 T2134 T2130 pobj glycoprotein,as
R1294 T2135 T2134 amod high,glycoprotein
R1295 T2136 T2134 amod endothelial,glycoprotein
R1296 T2137 T2134 compound cell,glycoprotein
R1297 T2138 T2134 punct (,glycoprotein
R1298 T2139 T2134 appos Lrhg,glycoprotein
R1299 T2140 T2127 punct ),known
R1300 T2141 T2127 cc and,known
R1301 T2142 T2143 aux has,shown
R1302 T2143 T2127 conj shown,known
R1303 T2144 T2143 auxpass been,shown
R1304 T2145 T2146 aux to,be
R1305 T2146 T2143 xcomp be,shown
R1306 T2147 T2148 det a,marker
R1307 T2148 T2146 attr marker,be
R1308 T2149 T2148 prep of,marker
R1309 T2150 T2151 amod high,venules
R1310 T2151 T2149 pobj venules,of
R1311 T2152 T2151 amod endothelial,venules
R1312 T2153 T2151 punct (,venules
R1313 T2154 T2151 appos HEV,venules
R1314 T2155 T2148 punct ),marker
R1315 T2156 T2157 punct [,24
R1316 T2157 T2148 parataxis 24,marker
R1317 T2158 T2157 punct ],24
R1318 T2159 T2160 dep which,increase
R1319 T2160 T2148 relcl increase,marker
R1320 T2161 T2160 prep in,increase
R1321 T2162 T2161 pobj tissues,in
R1322 T2163 T2160 prep during,increase
R1323 T2164 T2163 pobj inflammation,during
R1324 T2165 T2166 punct [,26
R1325 T2166 T2143 parataxis 26,shown
R1326 T2167 T2166 nummod 25,26
R1327 T2168 T2166 punct ",",26
R1328 T2169 T2166 punct ],26
R1329 T2170 T2127 punct .,known
R1330 T2172 T2173 amod Hematopoietic,transcript
R1331 T2173 T2175 nsubj transcript,is
R1332 T2174 T2173 compound cell,transcript
R1333 T2176 T2173 nummod 1,transcript
R1334 T2177 T2173 punct (,transcript
R1335 T2178 T2173 appos HemT1,transcript
R1336 T2179 T2173 punct ", ",transcript
R1337 T2180 T2181 punct [,27
R1338 T2181 T2173 parataxis 27,transcript
R1339 T2182 T2181 punct ],27
R1340 T2183 T2173 punct ),transcript
R1341 T2184 T2185 det a,marker
R1342 T2185 T2175 attr marker,is
R1343 T2186 T2185 prep of,marker
R1344 T2187 T2188 compound blood,proliferation
R1345 T2188 T2186 pobj proliferation,of
R1346 T2189 T2188 compound cell,proliferation
R1347 T2190 T2175 cc and,is
R1348 T2191 T2192 poss its,expression
R1349 T2192 T2193 nsubj expression,is
R1350 T2193 T2175 conj is,is
R1351 T2194 T2195 advmod strongly,elevated
R1352 T2195 T2193 acomp elevated,is
R1353 T2196 T2193 prep in,is
R1354 T2197 T2198 det the,intestine
R1355 T2198 T2196 pobj intestine,in
R1356 T2199 T2200 nmod B6,mouse
R1357 T2200 T2198 nmod mouse,intestine
R1358 T2201 T2200 nmod CF,mouse
R1359 T2202 T2198 amod small,intestine
R1360 T2203 T2193 punct .,is
R1361 T2205 T2206 compound Serum,A3
R1362 T2206 T2208 nsubj A3,is
R1363 T2207 T2206 compound amyloid,A3
R1364 T2209 T2206 punct (,A3
R1365 T2210 T2206 appos SAA3,A3
R1366 T2211 T2206 punct ", ",A3
R1367 T2212 T2213 punct [,28
R1368 T2213 T2206 parataxis 28,A3
R1369 T2214 T2213 punct ],28
R1370 T2215 T2206 punct ),A3
R1371 T2216 T2217 det an,gene
R1372 T2217 T2208 attr gene,is
R1373 T2218 T2217 amod acute,gene
R1374 T2219 T2217 compound phase,gene
R1375 T2220 T2208 cc and,is
R1376 T2221 T2222 poss its,expression
R1377 T2222 T2223 nsubj expression,is
R1378 T2223 T2208 conj is,is
R1379 T2224 T2222 prep in,expression
R1380 T2225 T2226 nmod villus,cells
R1381 T2226 T2224 pobj cells,in
R1382 T2227 T2226 amod epithelial,cells
R1383 T2228 T2223 acomp increased,is
R1384 T2229 T2223 prep in,is
R1385 T2230 T2231 det the,intestine
R1386 T2231 T2229 pobj intestine,in
R1387 T2232 T2233 compound B6,CF
R1388 T2233 T2231 compound CF,intestine
R1389 T2234 T2223 punct .,is
R1390 T2236 T2237 nsubj Suppressor,is
R1391 T2238 T2236 prep of,Suppressor
R1392 T2239 T2240 compound cytokine,signaling
R1393 T2240 T2238 pobj signaling,of
R1394 T2241 T2240 nummod 3,signaling
R1395 T2242 T2240 punct (,signaling
R1396 T2243 T2240 appos SOCS3,signaling
R1397 T2244 T2240 punct ", ",signaling
R1398 T2245 T2246 punct [,29
R1399 T2246 T2240 parataxis 29,signaling
R1400 T2247 T2246 punct ],29
R1401 T2248 T2237 punct ),is
R1402 T2249 T2250 det an,gene
R1403 T2250 T2237 attr gene,is
R1404 T2251 T2250 amod anti-inflammatory,gene
R1405 T2252 T2253 dep that,interacts
R1406 T2253 T2250 relcl interacts,gene
R1407 T2254 T2253 prep with,interacts
R1408 T2255 T2256 det the,pathway
R1409 T2256 T2254 pobj pathway,with
R1410 T2257 T2258 compound JAK,STAT
R1411 T2258 T2256 compound STAT,pathway
R1412 T2259 T2258 punct -,STAT
R1413 T2260 T2237 cc and,is
R1414 T2261 T2262 poss its,expression
R1415 T2262 T2263 nsubj expression,in
R1416 T2263 T2237 conj in,is
R1417 T2264 T2263 acomp increased,in
R1418 T2265 T2263 prep in,in
R1419 T2266 T2267 det the,intestine
R1420 T2267 T2265 pobj intestine,in
R1421 T2268 T2269 compound B6,CF
R1422 T2269 T2267 compound CF,intestine
R1423 T2270 T2263 punct .,in
R1424 T2272 T2273 nmod Muclin,expression
R1425 T2273 T2284 nsubjpass expression,upregulated
R1426 T2274 T2275 punct (,known
R1427 T2275 T2273 parataxis known,expression
R1428 T2276 T2275 advmod also,known
R1429 T2277 T2275 prep as,known
R1430 T2278 T2277 pobj dmbt1,as
R1431 T2279 T2278 punct ", ",dmbt1
R1432 T2280 T2281 punct [,30
R1433 T2281 T2278 parataxis 30,dmbt1
R1434 T2282 T2281 punct ],30
R1435 T2283 T2275 punct ),known
R1436 T2284 T2286 ccomp upregulated,is
R1437 T2285 T2284 auxpass is,upregulated
R1438 T2287 T2284 prep in,upregulated
R1439 T2288 T2289 det the,intestine
R1440 T2289 T2287 pobj intestine,in
R1441 T2290 T2291 compound B6,CF
R1442 T2291 T2289 compound CF,intestine
R1443 T2292 T2286 punct ;,is
R1444 T2293 T2286 nsubj it,is
R1445 T2294 T2295 det a,glycoprotein
R1446 T2295 T2286 attr glycoprotein,is
R1447 T2296 T2295 compound cell,glycoprotein
R1448 T2297 T2295 compound surface,glycoprotein
R1449 T2298 T2295 acl postulated,glycoprotein
R1450 T2299 T2300 aux to,be
R1451 T2300 T2298 xcomp be,postulated
R1452 T2301 T2302 det an,molecule
R1453 T2302 T2300 attr molecule,be
R1454 T2303 T2302 amod epithelial,molecule
R1455 T2304 T2302 amod protective,molecule
R1456 T2305 T2306 punct [,31
R1457 T2306 T2286 parataxis 31,is
R1458 T2307 T2306 nummod 21,31
R1459 T2308 T2306 punct ",",31
R1460 T2309 T2306 punct ],31
R1461 T2310 T2286 punct .,is
R1462 T2312 T2313 advcl Consistent,increased
R1463 T2314 T2312 prep with,Consistent
R1464 T2315 T2316 amod previous,results
R1465 T2316 T2314 pobj results,with
R1466 T2317 T2313 punct ", ",increased
R1467 T2318 T2313 nsubjpass Mcpt2,increased
R1468 T2319 T2313 auxpass was,increased
R1469 T2320 T2313 prep in,increased
R1470 T2321 T2322 compound CF,mice
R1471 T2322 T2320 pobj mice,in
R1472 T2323 T2322 prep on,mice
R1473 T2324 T2325 det the,background
R1474 T2325 T2323 pobj background,on
R1475 T2326 T2325 compound B6,background
R1476 T2327 T2313 prep by,increased
R1477 T2328 T2329 quantmod over,9-fold
R1478 T2329 T2327 pcomp 9-fold,by
R1479 T2330 T2313 prep compared,increased
R1480 T2331 T2330 prep to,compared
R1481 T2332 T2333 amod wild,type
R1482 T2333 T2331 pobj type,to
R1483 T2334 T2335 punct (,Fig.
R1484 T2335 T2313 parataxis Fig.,increased
R1485 T2336 T2335 nummod 2A,Fig.
R1486 T2337 T2335 punct ),Fig.
R1487 T2338 T2313 punct .,increased
R1488 T2340 T2341 prep By,was
R1489 T2342 T2340 pobj contrast,By
R1490 T2343 T2341 punct ", ",was
R1491 T2344 T2341 expl there,was
R1492 T2345 T2341 neg not,was
R1493 T2346 T2347 det a,difference
R1494 T2347 T2341 attr difference,was
R1495 T2348 T2347 amod significant,difference
R1496 T2349 T2347 prep in,difference
R1497 T2350 T2351 compound Mcpt2,expression
R1498 T2351 T2349 pobj expression,in
R1499 T2352 T2351 prep between,expression
R1500 T2353 T2352 pobj CF,between
R1501 T2354 T2353 cc and,CF
R1502 T2355 T2356 amod wild,type
R1503 T2356 T2353 conj type,CF
R1504 T2357 T2353 prep on,CF
R1505 T2358 T2359 det the,background
R1506 T2359 T2357 pobj background,on
R1507 T2360 T2359 amod mixed,background
R1508 T2361 T2362 punct (,Fig.
R1509 T2362 T2341 parataxis Fig.,was
R1510 T2363 T2362 nummod 2A,Fig.
R1511 T2364 T2362 punct ),Fig.
R1512 T2365 T2341 punct .,was
R1513 T2367 T2368 compound Lrg1,Lrhg
R1514 T2368 T2370 compound Lrhg,expression
R1515 T2369 T2368 punct /,Lrhg
R1516 T2370 T2371 nsubjpass expression,increased
R1517 T2372 T2371 auxpass was,increased
R1518 T2373 T2374 advmod more,20-fold
R1519 T2374 T2371 advmod 20-fold,increased
R1520 T2375 T2374 quantmod than,20-fold
R1521 T2376 T2371 prep in,increased
R1522 T2377 T2378 compound CF,mice
R1523 T2378 T2376 pobj mice,in
R1524 T2379 T2378 prep on,mice
R1525 T2380 T2381 det the,background
R1526 T2381 T2379 pobj background,on
R1527 T2382 T2381 compound B6,background
R1528 T2383 T2371 prep compared,increased
R1529 T2384 T2383 prep to,compared
R1530 T2385 T2386 amod wild,type
R1531 T2386 T2384 pobj type,to
R1532 T2387 T2371 punct ", ",increased
R1533 T2388 T2371 cc but,increased
R1534 T2389 T2390 expl there,was
R1535 T2390 T2371 conj was,increased
R1536 T2391 T2392 det no,difference
R1537 T2392 T2390 attr difference,was
R1538 T2393 T2392 amod significant,difference
R1539 T2394 T2392 prep between,difference
R1540 T2395 T2394 pobj CF,between
R1541 T2396 T2395 cc and,CF
R1542 T2397 T2398 amod wild,type
R1543 T2398 T2395 conj type,CF
R1544 T2399 T2395 prep on,CF
R1545 T2400 T2401 det the,background
R1546 T2401 T2399 pobj background,on
R1547 T2402 T2401 amod mixed,background
R1548 T2403 T2404 punct (,Fig.
R1549 T2404 T2390 parataxis Fig.,was
R1550 T2405 T2404 nummod 2B,Fig.
R1551 T2406 T2404 punct ),Fig.
R1552 T2407 T2390 punct .,was
R1553 T2409 T2410 compound SAA3,mRNA
R1554 T2410 T2411 nsubj mRNA,was
R1555 T2412 T2413 quantmod about,3.5-fold
R1556 T2413 T2414 advmod 3.5-fold,increased
R1557 T2414 T2411 acomp increased,was
R1558 T2415 T2411 prep in,was
R1559 T2416 T2417 compound CF,mice
R1560 T2417 T2415 pobj mice,in
R1561 T2418 T2417 prep on,mice
R1562 T2419 T2420 det the,background
R1563 T2420 T2418 pobj background,on
R1564 T2421 T2420 compound B6,background
R1565 T2422 T2411 punct ", ",was
R1566 T2423 T2411 cc but,was
R1567 T2424 T2411 conj was,was
R1568 T2425 T2424 neg not,was
R1569 T2426 T2427 advmod significantly,different
R1570 T2427 T2424 acomp different,was
R1571 T2428 T2424 prep compared,was
R1572 T2429 T2428 prep to,compared
R1573 T2430 T2431 amod wild,type
R1574 T2431 T2429 pobj type,to
R1575 T2432 T2431 prep on,type
R1576 T2433 T2434 det the,background
R1577 T2434 T2432 pobj background,on
R1578 T2435 T2434 amod mixed,background
R1579 T2436 T2437 punct (,Fig.
R1580 T2437 T2424 parataxis Fig.,was
R1581 T2438 T2437 nummod 2C,Fig.
R1582 T2439 T2437 punct ),Fig.
R1583 T2440 T2411 punct .,was
R1584 T2442 T2443 nsubj SOCS3,was
R1585 T2444 T2445 amod more,2-fold
R1586 T2445 T2447 advmod 2-fold,increased
R1587 T2446 T2445 quantmod than,2-fold
R1588 T2447 T2443 acomp increased,was
R1589 T2448 T2443 prep in,was
R1590 T2449 T2450 compound CF,mice
R1591 T2450 T2448 pobj mice,in
R1592 T2451 T2450 prep on,mice
R1593 T2452 T2453 det the,background
R1594 T2453 T2451 pobj background,on
R1595 T2454 T2453 compound B6,background
R1596 T2455 T2443 prep compared,was
R1597 T2456 T2455 prep to,compared
R1598 T2457 T2458 amod wild,type
R1599 T2458 T2456 pobj type,to
R1600 T2459 T2443 punct ", ",was
R1601 T2460 T2443 cc and,was
R1602 T2461 T2462 prep on,was
R1603 T2462 T2443 conj was,was
R1604 T2463 T2464 det the,background
R1605 T2464 T2461 pobj background,on
R1606 T2465 T2464 amod mixed,background
R1607 T2466 T2467 advmod only,1.5-fold
R1608 T2467 T2468 advmod 1.5-fold,greater
R1609 T2468 T2462 acomp greater,was
R1610 T2469 T2468 prep than,greater
R1611 T2470 T2471 amod wild,type
R1612 T2471 T2469 pobj type,than
R1613 T2472 T2443 punct ", ",was
R1614 T2473 T2443 cc and,was
R1615 T2474 T2475 det the,difference
R1616 T2475 T2476 nsubj difference,was
R1617 T2476 T2443 conj was,was
R1618 T2477 T2476 neg not,was
R1619 T2478 T2476 acomp significant,was
R1620 T2479 T2480 punct (,Fig.
R1621 T2480 T2476 parataxis Fig.,was
R1622 T2481 T2480 nummod 2D,Fig.
R1623 T2482 T2480 punct ),Fig.
R1624 T2483 T2476 punct .,was
R1625 T2485 T2486 nsubjpass Muclin,overexpressed
R1626 T2487 T2486 auxpass is,overexpressed
R1627 T2488 T2489 advmod almost,3-fold
R1628 T2489 T2486 advmod 3-fold,overexpressed
R1629 T2490 T2486 prep in,overexpressed
R1630 T2491 T2492 det the,intestine
R1631 T2492 T2490 pobj intestine,in
R1632 T2493 T2492 compound CF,intestine
R1633 T2494 T2492 prep on,intestine
R1634 T2495 T2496 det the,background
R1635 T2496 T2494 pobj background,on
R1636 T2497 T2496 compound B6,background
R1637 T2498 T2486 punct ", ",overexpressed
R1638 T2499 T2486 cc but,overexpressed
R1639 T2500 T2501 prep on,was
R1640 T2501 T2486 conj was,overexpressed
R1641 T2502 T2503 det the,background
R1642 T2503 T2500 pobj background,on
R1643 T2504 T2503 amod mixed,background
R1644 T2505 T2506 det the,level
R1645 T2506 T2501 nsubj level,was
R1646 T2507 T2506 compound expression,level
R1647 T2508 T2506 prep in,level
R1648 T2509 T2510 compound CF,mice
R1649 T2510 T2508 pobj mice,in
R1650 T2511 T2501 neg not,was
R1651 T2512 T2513 advmod significantly,different
R1652 T2513 T2501 acomp different,was
R1653 T2514 T2513 prep than,different
R1654 T2515 T2516 amod wild,type
R1655 T2516 T2514 pobj type,than
R1656 T2517 T2518 punct (,Fig.
R1657 T2518 T2501 parataxis Fig.,was
R1658 T2519 T2518 nummod 2E,Fig.
R1659 T2520 T2518 punct ),Fig.
R1660 T2521 T2501 punct .,was
R1661 T2523 T2524 advmod Finally,overexpressed
R1662 T2525 T2524 punct ", ",overexpressed
R1663 T2526 T2524 nsubjpass HemT1,overexpressed
R1664 T2527 T2524 auxpass was,overexpressed
R1697 T2561 T2562 prep Because,analyzed
R1698 T2563 T2561 pcomp of,Because
R1699 T2564 T2565 det the,differences
R1700 T2565 T2561 pobj differences,Because
R1701 T2566 T2565 compound gender,differences
R1702 T2567 T2565 prep in,differences
R1703 T2568 T2569 compound body,weight
R1704 T2569 T2567 pobj weight,in
R1705 T2570 T2562 punct ", ",analyzed
R1706 T2571 T2572 det the,data
R1707 T2572 T2562 nsubjpass data,analyzed
R1708 T2573 T2574 compound gene,expression
R1709 T2574 T2572 compound expression,data
R1710 T2575 T2562 auxpass were,analyzed
R1711 T2576 T2562 prep by,analyzed
R1712 T2577 T2576 pobj gender,by
R1713 T2578 T2562 cc but,analyzed
R1714 T2579 T2580 expl there,was
R1715 T2580 T2562 conj was,analyzed
R1716 T2581 T2582 det no,difference
R1717 T2582 T2580 attr difference,was
R1718 T2583 T2582 amod significant,difference
R1719 T2584 T2582 prep between,difference
R1720 T2585 T2584 pobj females,between
R1721 T2586 T2585 cc and,females
R1722 T2587 T2585 conj males,females
R1723 T2588 T2580 punct .,was
R1724 T2590 T2591 prep With,was
R1725 T2592 T2593 det the,number
R1726 T2593 T2590 pobj number,With
R1727 T2594 T2593 amod limited,number
R1728 T2595 T2593 prep of,number
R1729 T2596 T2595 pobj animals,of
R1730 T2597 T2591 punct ", ",was
R1731 T2598 T2591 expl there,was
R1732 T2599 T2591 advmod also,was
R1733 T2600 T2601 det no,evidence
R1734 T2601 T2591 attr evidence,was
R1735 T2602 T2601 prep for,evidence
R1736 T2603 T2602 pobj imprinting,for
R1737 T2604 T2591 punct .,was
R1738 T2802 T2803 compound CF,mice
R1739 T2803 T2804 nsubj mice,have
R1740 T2805 T2803 prep on,mice
R1741 T2806 T2807 det the,background
R1742 T2807 T2805 pobj background,on
R1743 T2808 T2807 amod mixed,background
R1744 T2809 T2810 advmod less,accumulation
R1745 T2810 T2804 dobj accumulation,have
R1746 T2811 T2812 amod intestinal,mucus
R1747 T2812 T2810 compound mucus,accumulation
R1748 T2814 T2815 det The,difference
R1749 T2815 T2819 nsubj difference,is
R1750 T2816 T2817 advmod most,striking
R1751 T2817 T2815 amod striking,difference
R1752 T2818 T2815 amod histological,difference
R1753 T2820 T2815 prep in,difference
R1754 T2821 T2822 det the,intestine
R1755 T2822 T2820 pobj intestine,in
R1756 T2823 T2824 nmod CF,mouse
R1757 T2824 T2822 nmod mouse,intestine
R1758 T2825 T2822 amod small,intestine
R1759 T2826 T2827 det the,accumulation
R1760 T2827 T2819 attr accumulation,is
R1761 T2828 T2827 prep of,accumulation
R1762 T2829 T2828 pobj mucus,of
R1763 T2830 T2827 prep in,accumulation
R1764 T2831 T2832 amod intestinal,crypts
R1765 T2832 T2830 pobj crypts,in
R1766 T2833 T2834 dep which,associated
R1767 T2834 T2827 relcl associated,accumulation
R1768 T2835 T2834 auxpass is,associated
R1769 T2836 T2834 prep with,associated
R1770 T2837 T2838 det the,obstruction
R1771 T2838 T2836 pobj obstruction,with
R1772 T2839 T2838 amod lethal,obstruction
R1773 T2840 T2841 dep that,results
R1774 T2841 T2838 relcl results,obstruction
R1775 T2842 T2841 prep in,results
R1776 T2843 T2842 pobj death,in
R1777 T2844 T2843 prep of,death
R1778 T2845 T2846 det these,mice
R1779 T2846 T2844 pobj mice,of
R1780 T2847 T2841 prep on,results
R1781 T2848 T2849 det a,diet
R1782 T2849 T2847 pobj diet,on
R1783 T2850 T2849 amod standard,diet
R1784 T2851 T2849 amod solid,diet
R1785 T2852 T2849 compound chow,diet
R1786 T2853 T2854 punct [,32
R1787 T2854 T2819 parataxis 32,is
R1788 T2855 T2854 punct ],32
R1789 T2856 T2819 punct .,is
R1790 T2858 T2859 advcl Using,performed
R1791 T2860 T2861 amod periodic,acid
R1792 T2861 T2862 nmod acid,staining
R1793 T2862 T2858 dobj staining,Using
R1794 T2863 T2862 poss Schiff,staining
R1795 T2864 T2863 case 's,Schiff
R1796 T2865 T2858 prep for,Using
R1797 T2866 T2867 amod neutral,mucins
R1798 T2867 T2865 pobj mucins,for
R1799 T2868 T2859 punct ", ",performed
R1800 T2869 T2870 amod histological,analysis
R1801 T2870 T2859 nsubjpass analysis,performed
R1802 T2871 T2870 prep of,analysis
R1803 T2872 T2873 amod small,tissues
R1804 T2873 T2871 pobj tissues,of
R1805 T2874 T2873 compound intestine,tissues
R1806 T2875 T2859 auxpass was,performed
R1807 T2876 T2859 punct .,performed
R1808 T2878 T2879 det The,intestine
R1809 T2879 T2883 nsubj intestine,were
R1810 T2880 T2881 amod wild,type
R1811 T2881 T2879 nmod type,intestine
R1812 T2882 T2879 amod small,intestine
R1813 T2884 T2879 prep on,intestine
R1814 T2885 T2886 preconj both,B6
R1815 T2886 T2884 pobj B6,on
R1816 T2887 T2886 det the,B6
R1817 T2888 T2886 cc and,B6
R1818 T2889 T2890 det the,mixed
R1819 T2890 T2891 nmod mixed,backgrounds
R1820 T2891 T2886 conj backgrounds,B6
R1821 T2892 T2891 amod genetic,backgrounds
R1822 T2893 T2883 acomp similar,were
R1823 T2894 T2883 punct .,were
R1824 T2896 T2897 det The,crypts
R1825 T2897 T2899 nsubj crypts,were
R1826 T2898 T2897 amod intestinal,crypts
R1827 T2900 T2901 advmod very,small
R1828 T2901 T2899 acomp small,were
R1829 T2902 T2899 prep with,were
R1830 T2903 T2904 amod only,traces
R1831 T2904 T2902 pobj traces,with
R1832 T2905 T2904 prep of,traces
R1833 T2906 T2907 compound PAS,reactivity
R1834 T2907 T2905 pobj reactivity,of
R1835 T2908 T2907 punct -,reactivity
R1836 T2909 T2904 prep in,traces
R1837 T2910 T2911 det the,lumen
R1838 T2911 T2909 pobj lumen,in
R1839 T2912 T2913 punct (,3A
R1840 T2913 T2899 parataxis 3A,were
R1841 T2914 T2913 nmod Fig.,3A
R1842 T2915 T2913 cc and,3A
R1843 T2916 T2913 conj 3C,3A
R1844 T2917 T2913 punct ", ",3A
R1845 T2918 T2913 advmod respectively,3A
R1846 T2919 T2913 punct ),3A
R1847 T2920 T2899 punct .,were
R1848 T2922 T2923 det The,surfaces
R1849 T2923 T2924 nsubj surfaces,were
R1850 T2925 T2923 prep of,surfaces
R1851 T2926 T2927 det the,epithelium
R1852 T2927 T2925 pobj epithelium,of
R1853 T2928 T2927 compound villus,epithelium
R1854 T2929 T2930 advmod moderately,stained
R1855 T2930 T2924 acomp stained,were
R1856 T2931 T2924 cc and,were
R1857 T2932 T2933 compound goblet,cells
R1858 T2933 T2934 nsubjpass cells,stained
R1859 T2934 T2924 conj stained,were
R1860 T2935 T2934 auxpass were,stained
R1861 T2936 T2934 advmod strongly,stained
R1862 T2937 T2934 prep in,stained
R1863 T2938 T2939 det the,tissues
R1864 T2939 T2937 pobj tissues,in
R1865 T2940 T2941 amod wild,type
R1866 T2941 T2939 compound type,tissues
R1867 T2942 T2934 punct .,stained
R1868 T2944 T2945 prep In,exhibited
R1869 T2946 T2944 pobj contrast,In
R1870 T2947 T2945 punct ", ",exhibited
R1871 T2948 T2949 det the,intestine
R1872 T2949 T2945 nsubj intestine,exhibited
R1873 T2950 T2949 prep of,intestine
R1874 T2951 T2952 compound CF,mice
R1875 T2952 T2950 pobj mice,of
R1876 T2953 T2952 prep on,mice
R1877 T2954 T2955 det the,background
R1878 T2955 T2953 pobj background,on
R1879 T2956 T2955 nmod B6,background
R1880 T2957 T2955 amod genetic,background
R1881 T2958 T2959 advmod greatly,dilated
R1882 T2959 T2960 amod dilated,crypts
R1883 T2960 T2945 dobj crypts,exhibited
R1884 T2961 T2960 acl filled,crypts
R1885 T2962 T2961 prep with,filled
R1886 T2963 T2964 npadvmod PAS,reactive
R1887 T2964 T2966 amod reactive,mucus
R1888 T2965 T2964 punct -,reactive
R1889 T2966 T2962 pobj mucus,with
R1890 T2967 T2968 punct (,Fig.
R1891 T2968 T2945 parataxis Fig.,exhibited
R1892 T2969 T2968 nummod 3B,Fig.
R1893 T2970 T2968 punct ),Fig.
R1894 T2971 T2945 punct .,exhibited
R1895 T2973 T2974 compound CF,mice
R1896 T2974 T2975 nsubj mice,had
R1897 T2976 T2974 prep on,mice
R1898 T2977 T2978 det the,background
R1899 T2978 T2976 pobj background,on
R1900 T2979 T2978 amod mixed,background
R1901 T2980 T2981 amod less,accumulation
R1902 T2981 T2975 dobj accumulation,had
R1903 T2982 T2981 compound mucus,accumulation
R1904 T2983 T2981 prep than,accumulation
R1905 T2984 T2985 compound CF,mice
R1906 T2985 T2983 pobj mice,than
R1907 T2986 T2985 prep on,mice
R1908 T2987 T2988 det the,background
R1909 T2988 T2986 pobj background,on
R1910 T2989 T2988 compound B6,background
R1911 T2990 T2991 punct (,Fig.
R1912 T2991 T2975 parataxis Fig.,had
R1913 T2992 T2991 nummod 3D,Fig.
R1914 T2993 T2994 punct -,F
R1915 T2994 T2991 prep F,Fig.
R1916 T2995 T2991 punct ),Fig.
R1917 T2996 T2975 punct .,had
R1918 T2998 T2999 det The,amount
R1919 T2999 T3000 nsubj amount,was
R1920 T3001 T2999 prep of,amount
R1921 T3002 T3001 pobj mucus,of
R1922 T3003 T2999 prep in,amount
R1923 T3004 T3005 compound CF,mice
R1924 T3005 T3003 pobj mice,in
R1925 T3006 T3005 prep on,mice
R1926 T3007 T3008 det the,background
R1927 T3008 T3006 pobj background,on
R1928 T3009 T3008 amod mixed,background
R1929 T3010 T3000 acomp variable,was
R1930 T3011 T3000 prep from,was
R1931 T3012 T3011 pobj mouse,from
R1932 T3013 T3011 prep to,from
R1933 T3014 T3013 pobj mouse,to
R1934 T3015 T3000 punct .,was
R1935 T3017 T3018 prep In,accumulated
R1936 T3019 T3020 det some,mice
R1937 T3020 T3017 pobj mice,In
R1938 T3021 T3022 punct (,Fig.
R1939 T3022 T3020 parataxis Fig.,mice
R1940 T3023 T3022 nummod 3D,Fig.
R1941 T3024 T3022 punct ),Fig.
R1942 T3025 T3018 punct ", ",accumulated
R1943 T3026 T3027 advmod only,crypts
R1944 T3027 T3018 nsubj crypts,accumulated
R1945 T3028 T3027 amod occasional,crypts
R1946 T3029 T3018 aux had,accumulated
R1947 T3030 T3018 dobj mucus,accumulated
R1948 T3031 T3018 cc and,accumulated
R1949 T3032 T3033 det the,lumina
R1950 T3033 T3035 nsubj lumina,were
R1951 T3034 T3033 compound crypt,lumina
R1952 T3035 T3018 conj were,accumulated
R1953 T3036 T3035 neg not,were
R1954 T3037 T3038 advmod very,dilated
R1955 T3038 T3035 acomp dilated,were
R1956 T3039 T3018 punct .,accumulated
R1957 T3041 T3042 prep In,was
R1958 T3043 T3044 det some,mice
R1959 T3044 T3041 pobj mice,In
R1960 T3045 T3042 expl there,was
R1961 T3046 T3047 amod more,mucus
R1962 T3047 T3042 attr mucus,was
R1963 T3048 T3042 prep in,was
R1964 T3049 T3050 det the,crypts
R1965 T3050 T3048 pobj crypts,in
R1966 T3051 T3052 punct (,Fig.
R1967 T3052 T3042 parataxis Fig.,was
R1968 T3053 T3052 nummod 3E,Fig.
R1969 T3054 T3052 punct ),Fig.
R1970 T3055 T3042 punct ", ",was
R1971 T3056 T3057 mark while,had
R1972 T3057 T3042 advcl had,was
R1973 T3058 T3057 nsubj others,had
R1974 T3059 T3060 amod moderate,accumulation
R1975 T3060 T3057 dobj accumulation,had
R1976 T3061 T3060 compound mucus,accumulation
R1977 T3062 T3063 punct (,Fig.
R1978 T3063 T3057 parataxis Fig.,had
R1979 T3064 T3063 nummod 3F,Fig.
R1980 T3065 T3063 punct ),Fig.
R1981 T3066 T3042 punct .,was
R1982 T3068 T3069 det A,total
R1983 T3069 T3070 nsubjpass total,examined
R1984 T3071 T3069 prep of,total
R1985 T3072 T3073 nummod six,mice
R1986 T3073 T3071 pobj mice,of
R1987 T3074 T3073 compound CF,mice
R1988 T3075 T3073 prep on,mice
R1989 T3076 T3077 det the,background
R1990 T3077 T3075 pobj background,on
R1991 T3078 T3077 amod mixed,background
R1992 T3079 T3070 auxpass were,examined
R1993 T3080 T3070 advmod histologically,examined
R1994 T3081 T3070 punct ", ",examined
R1995 T3082 T3070 cc and,examined
R1996 T3083 T3084 nsubj three,had
R1997 T3084 T3070 conj had,examined
R1998 T3085 T3086 amod little,mucus
R1999 T3086 T3084 dobj mucus,had
R2039 T3128 T3126 pobj background,on
R2040 T3129 T3128 compound B6,background
R2041 T3130 T3103 punct .,had
R2047 T3138 T3139 dep whatever,nature
R2048 T3139 T3137 advcl nature,affect
R2049 T3140 T3139 det the,nature
R2050 T3141 T3139 prep of,nature
R2051 T3142 T3143 det the,differences
R2052 T3143 T3141 pobj differences,of
R2053 T3144 T3143 amod genetic,differences
R2054 T3145 T3143 prep between,differences
R2055 T3146 T3147 det the,strains
R2056 T3147 T3145 pobj strains,between
R2057 T3148 T3147 nummod two,strains
R2058 T3149 T3147 compound background,strains
R2059 T3150 T3137 punct ", ",affect
R2060 T3151 T3137 nsubj they,affect
R2061 T3152 T3137 dobj secretion,affect
R2062 T3153 T3152 cc and,secretion
R2063 T3154 T3152 conj accumulation,secretion
R2064 T3155 T3152 prep of,secretion
R2065 T3156 T3155 pobj mucus,of
R2066 T3157 T3152 prep in,secretion
R2067 T3158 T3159 det the,intestine
R2068 T3159 T3157 pobj intestine,in
R2069 T3160 T3159 nmod CF,intestine
R2070 T3161 T3159 amod small,intestine
R2071 T3162 T3133 punct .,appears
R2072 T3164 T3165 aux To,determine
R2073 T3165 T3166 advcl determine,used
R2074 T3167 T3168 mark if,accounted
R2075 T3168 T3165 ccomp accounted,determine
R2076 T3169 T3170 det the,difference
R2077 T3170 T3168 nsubjpass difference,accounted
R2078 T3171 T3168 aux could,accounted
R2079 T3172 T3168 auxpass be,accounted
R2080 T3173 T3168 prep for,accounted
R2081 T3174 T3168 prep by,accounted
R2082 T3175 T3176 amod altered,gene
R2083 T3176 T3178 compound gene,expression
R2084 T3177 T3176 compound mucin,gene
R2085 T3178 T3174 pobj expression,by
R2086 T3179 T3166 punct ", ",used
R2087 T3180 T3181 amod quantitative,PCR
R2088 T3181 T3166 nsubjpass PCR,used
R2089 T3182 T3181 compound RT,PCR
R2090 T3183 T3181 punct -,PCR
R2091 T3184 T3166 auxpass was,used
R2092 T3185 T3186 aux to,measure
R2093 T3186 T3166 advcl measure,used
R2094 T3187 T3188 compound mRNA,expression
R2095 T3188 T3186 dobj expression,measure
R2096 T3189 T3188 prep of,expression
R2097 T3190 T3191 det the,gene
R2098 T3191 T3189 pobj gene,of
R2099 T3192 T3193 amod intestinal,cell
R2100 T3193 T3191 compound cell,gene
R2101 T3194 T3193 compound goblet,cell
R2102 T3195 T3191 compound mucin,gene
R2103 T3196 T3191 punct ", ",gene
R2104 T3197 T3191 appos Muc2,gene
R2105 T3198 T3166 punct .,used
R2106 T3200 T3201 prep In,had
R2107 T3202 T3203 amod wild,type
R2108 T3203 T3204 compound type,intestine
R2109 T3204 T3200 pobj intestine,In
R2110 T3205 T3201 punct ", ",had
R2111 T3206 T3207 compound B6,mice
R2112 T3207 T3201 nsubj mice,had
R2113 T3208 T3209 quantmod 0.079,0.024
R2114 T3209 T3213 nummod 0.024,copies
R2115 T3210 T3209 punct +,0.024
R2116 T3211 T3209 punct /,0.024
R2117 T3212 T3209 punct -,0.024
R2118 T3213 T3201 dobj copies,had
R2119 T3214 T3213 prep of,copies
R2120 T3215 T3216 compound Muc2,GAPDH
R2121 T3216 T3214 pobj GAPDH,of
R2122 T3217 T3216 punct /,GAPDH
R2123 T3218 T3219 punct (,8
R2124 T3219 T3213 parataxis 8,copies
R2125 T3220 T3219 nsubj n,8
R2126 T3221 T3219 punct =,8
R2127 T3222 T3219 punct ),8
R2128 T3223 T3201 punct ", ",had
R2129 T3224 T3201 cc and,had
R2130 T3225 T3226 prep on,was
R2131 T3226 T3201 conj was,had
R2132 T3227 T3228 det the,background
R2133 T3228 T3225 pobj background,on
R2134 T3229 T3228 amod mixed,background
R2135 T3230 T3231 det the,level
R2136 T3231 T3226 nsubj level,was
R2137 T3232 T3233 quantmod 0.077,0.012
R2138 T3233 T3226 attr 0.012,was
R2139 T3234 T3233 punct +,0.012
R2140 T3235 T3233 punct /,0.012
R2141 T3236 T3233 punct -,0.012
R2142 T3237 T3238 punct (,11
R2143 T3238 T3233 parataxis 11,0.012
R2144 T3239 T3238 nsubj n,11
R2145 T3240 T3238 punct =,11
R2146 T3241 T3238 punct ),11
R2147 T3242 T3226 punct .,was
R2148 T3244 T3245 compound CF,mice
R2149 T3245 T3246 nsubj mice,had
R2150 T3247 T3245 prep on,mice
R2151 T3248 T3249 det the,background
R2152 T3249 T3247 pobj background,on
R2153 T3250 T3249 compound B6,background
R2154 T3251 T3252 quantmod 0.059,0.024
R2155 T3252 T3256 nummod 0.024,copies
R2156 T3253 T3252 punct +,0.024
R2157 T3254 T3252 punct /,0.024
R2158 T3255 T3252 punct -,0.024
R2159 T3256 T3246 dobj copies,had
R2160 T3257 T3256 prep of,copies
R2161 T3258 T3259 compound Muc2,mRNA
R2162 T3259 T3257 pobj mRNA,of
R2163 T3260 T3256 prep per,copies
R2164 T3261 T3260 pobj GAPDH,per
R2165 T3262 T3263 punct (,11
R2166 T3263 T3256 parataxis 11,copies
R2167 T3264 T3263 nsubj n,11
R2168 T3265 T3263 punct =,11
R2169 T3266 T3263 punct ),11
R2170 T3267 T3246 punct ", ",had
R2171 T3268 T3246 cc and,had
R2172 T3269 T3270 prep on,was
R2173 T3270 T3246 conj was,had
R2174 T3271 T3272 det the,background
R2175 T3272 T3269 pobj background,on
R2176 T3273 T3272 amod mixed,background
R2177 T3274 T3275 det the,level
R2178 T3275 T3270 nsubj level,was
R2179 T3276 T3277 quantmod 0.056,0.010
R2180 T3277 T3270 attr 0.010,was
R2181 T3278 T3277 punct +,0.010
R2182 T3279 T3277 punct /,0.010
R2183 T3280 T3277 punct -,0.010
R2184 T3281 T3282 punct (,11
R2185 T3282 T3270 parataxis 11,was
R2186 T3283 T3282 nsubj n,11
R2187 T3284 T3282 punct =,11
R2188 T3285 T3282 punct ),11
R2189 T3286 T3270 punct .,was
R2190 T3288 T3289 prep Despite,is
R2191 T3290 T3291 det the,accumulation
R2192 T3291 T3288 pobj accumulation,Despite
R2193 T3292 T3291 amod increased,accumulation
R2194 T3293 T3291 compound mucus,accumulation
R2195 T3294 T3291 prep in,accumulation
R2196 T3295 T3294 pobj CF,in
R2197 T3296 T3289 punct ", ",is
R2198 T3297 T3289 expl there,is
R2199 T3298 T3299 det a,decrease
R2200 T3299 T3289 attr decrease,is
R2201 T3300 T3299 amod slight,decrease
R2202 T3301 T3299 prep in,decrease
R2203 T3302 T3303 compound Muc2,mRNA
R2204 T3303 T3301 pobj mRNA,in
R2205 T3304 T3289 prep in,is
R2206 T3305 T3306 det the,intestine
R2207 T3306 T3304 pobj intestine,in
R2208 T3307 T3306 nmod CF,intestine
R2209 T3308 T3306 amod small,intestine
R2210 T3309 T3310 punct (,0.0001
R2211 T3310 T3289 parataxis 0.0001,is
R2212 T3311 T3310 nsubj P,0.0001
R2213 T3312 T3310 punct <,0.0001
R2214 T3313 T3310 punct ),0.0001
R2215 T3314 T3289 punct ", ",is
R2216 T3315 T3316 mark as,reported
R2217 T3316 T3289 advcl reported,is
R2218 T3317 T3316 advmod previously,reported
R2219 T3318 T3319 punct [,33
R2220 T3319 T3289 parataxis 33,is
R2221 T3320 T3319 punct ],33
R2222 T3321 T3289 punct .,is
R2223 T3323 T3324 advmod However,involve
R2224 T3325 T3324 punct ", ",involve
R2225 T3326 T3327 det the,phenotype
R2226 T3327 T3324 nsubj phenotype,involve
R2227 T3328 T3327 amod milder,phenotype
R2228 T3329 T3327 compound CF,phenotype
R2229 T3330 T3327 prep on,phenotype
R2230 T3331 T3332 det the,background
R2231 T3332 T3330 pobj background,on
R2232 T3333 T3332 amod mixed,background
R2233 T3334 T3327 punct ", ",phenotype
R2234 T3335 T3336 dep which,includes
R2235 T3336 T3327 relcl includes,phenotype
R2236 T3337 T3338 amod less,accumulation
R2237 T3338 T3336 dobj accumulation,includes
R2238 T3339 T3338 compound mucus,accumulation
R2239 T3340 T3324 punct ", ",involve
R2240 T3341 T3324 aux does,involve
R2241 T3342 T3324 neg not,involve
R2242 T3343 T3344 amod decreased,expression
R2243 T3344 T3324 dobj expression,involve
R2244 T3345 T3346 compound mucin,gene
R2245 T3346 T3344 compound gene,expression
R2246 T3347 T3324 punct .,involve
R2247 T3428 T3429 compound CF,mice
R2248 T3429 T3430 nsubj mice,have
R2249 T3431 T3429 prep on,mice
R2250 T3432 T3433 det the,background
R2251 T3433 T3431 pobj background,on
R2252 T3434 T3433 amod mixed,background
R2253 T3435 T3436 amod improved,survival
R2254 T3436 T3430 dobj survival,have
R2255 T3438 T3439 mark As,reported
R2256 T3439 T3440 advcl reported,was
R2257 T3441 T3439 agent by,reported
R2258 T3442 T3441 pobj others,by
R2259 T3443 T3444 punct [,34
R2260 T3444 T3439 parataxis 34,reported
R2261 T3445 T3444 punct ],34
R2262 T3446 T3440 punct ", ",was
R2263 T3447 T3448 det the,number
R2264 T3448 T3440 nsubj number,was
R2265 T3449 T3448 amod expected,number
R2266 T3450 T3448 prep of,number
R2267 T3451 T3452 nmod Cftr,mice
R2268 T3452 T3450 pobj mice,of
R2269 T3453 T3452 amod null,mice
R2270 T3454 T3452 prep on,mice
R2271 T3455 T3456 det the,background
R2272 T3456 T3454 pobj background,on
R2273 T3457 T3456 compound B6,background
R2274 T3458 T3459 dep that,survived
R2275 T3459 T3448 relcl survived,number
R2276 T3460 T3459 prep to,survived
R2277 T3461 T3460 pobj weaning,to
R2278 T3462 T3463 advmod significantly,less
R2279 T3463 T3440 acomp less,was
R2280 T3464 T3463 prep than,less
R2281 T3465 T3464 pobj that,than
R2282 T3466 T3465 acl expected,that
R2283 T3467 T3466 prep from,expected
R2284 T3468 T3469 amod Mendelian,genetics
R2285 T3469 T3467 pobj genetics,from
R2286 T3470 T3471 punct (,1
R2287 T3471 T3440 parataxis 1,was
R2288 T3472 T3471 nmod Tables,1
R2289 T3473 T3471 cc and,1
R2290 T3474 T3471 conj 2,1
R2291 T3475 T3471 punct ),1
R2292 T3476 T3440 punct .,was
R2293 T3478 T3479 det The,degree
R2294 T3479 T3480 nsubj degree,was
R2295 T3481 T3479 prep of,degree
R2296 T3482 T3481 pobj significance,of
R2297 T3483 T3480 acomp greater,was
R2298 T3484 T3480 prep for,was
R2299 T3485 T3486 amod male,mice
R2300 T3486 T3484 pobj mice,for
R2301 T3487 T3488 punct (,1
R2302 T3488 T3480 parataxis 1,was
R2303 T3489 T3488 nmod Tables,1
R2304 T3490 T3488 cc and,1
R2305 T3491 T3488 conj 2,1
R2306 T3492 T3488 punct ),1
R2307 T3493 T3480 punct .,was
R2308 T3495 T3496 prep In,was
R2309 T3497 T3495 pobj contrast,In
R2310 T3498 T3496 punct ", ",was
R2311 T3499 T3496 prep on,was
R2312 T3500 T3501 det the,background
R2313 T3501 T3499 pobj background,on
R2314 T3502 T3501 amod mixed,background
R2335 T3525 T3526 amod male,mice
R2336 T3526 T3523 pobj mice,For
R2337 T3527 T3526 prep on,mice
R2338 T3528 T3529 det the,background
R2339 T3529 T3527 pobj background,on
R2340 T3530 T3529 amod mixed,background
R2341 T3531 T3524 punct ", ",was
R2342 T3532 T3533 det the,value
R2343 T3533 T3524 nsubj value,was
R2344 T3534 T3533 compound P,value
R2345 T3535 T3533 punct -,value
R2346 T3536 T3537 advmod less,significant
R2347 T3537 T3524 acomp significant,was
R2348 T3538 T3537 cc but,significant
R2349 T3539 T3540 advmod still,different
R2350 T3540 T3537 conj different,significant
R2351 T3541 T3524 prep compared,was
R2352 T3542 T3541 prep to,compared
R2353 T3543 T3544 det the,males
R2354 T3544 T3542 pobj males,to
R2355 T3545 T3544 compound B6,males
R2356 T3546 T3547 punct (,Table
R2357 T3547 T3524 parataxis Table,was
R2358 T3548 T3547 nummod 2,Table
R2359 T3549 T3547 punct ),Table
R2360 T3550 T3524 punct .,was
R2361 T3552 T3553 det These,data
R2362 T3553 T3554 nsubj data,indicate
R2363 T3555 T3556 mark that,associated
R2364 T3556 T3554 ccomp associated,indicate
R2365 T3557 T3558 det the,background
R2366 T3558 T3556 nsubjpass background,associated
R2367 T3559 T3558 amod mixed,background
R2368 T3560 T3556 auxpass is,associated
R2369 T3561 T3556 prep with,associated
R2370 T3562 T3563 amod increased,survival
R2371 T3563 T3561 pobj survival,with
R2372 T3564 T3563 prep of,survival
R2373 T3565 T3566 compound CF,mice
R2374 T3566 T3564 pobj mice,of
R2375 T3567 T3554 punct .,indicate
R2392 T3586 T3587 advmod when,fed
R2393 T3587 T3584 advcl fed,worsened
R2394 T3588 T3589 det the,mice
R2395 T3589 T3587 nsubjpass mice,fed
R2396 T3590 T3587 auxpass are,fed
R2397 T3591 T3592 amod standard,chow
R2398 T3592 T3587 dobj chow,fed
R2399 T3593 T3592 amod solid,chow
R2400 T3594 T3592 compound mouse,chow
R2401 T3595 T3596 punct [,35
R2402 T3596 T3584 parataxis 35,worsened
R2403 T3597 T3596 punct ],35
R2404 T3598 T3584 punct .,worsened
R2405 T3600 T3601 mark Since,had
R2406 T3601 T3609 advcl had,tested
R2407 T3602 T3603 det the,mice
R2408 T3603 T3601 nsubj mice,had
R2409 T3604 T3603 compound CF,mice
R2410 T3605 T3603 prep on,mice
R2411 T3606 T3607 det the,background
R2412 T3607 T3605 pobj background,on
R2413 T3608 T3607 amod mixed,background
R2414 T3610 T3611 amod better,gain
R2415 T3611 T3601 dobj gain,had
R2416 T3612 T3611 compound weight,gain
R2417 T3613 T3611 prep than,gain
R2418 T3614 T3613 prep on,than
R2419 T3615 T3616 det the,background
R2420 T3616 T3614 pobj background,on
R2421 T3617 T3616 compound B6,background
R2422 T3618 T3611 cc and,gain
R2423 T3619 T3620 amod less,accumulation
R2424 T3620 T3611 conj accumulation,gain
R2425 T3621 T3620 compound mucus,accumulation
R2426 T3622 T3620 prep in,accumulation
R2427 T3623 T3624 det the,intestine
R2428 T3624 T3622 pobj intestine,in
R2429 T3625 T3624 amod small,intestine
R2430 T3626 T3609 punct ", ",tested
R2431 T3627 T3628 poss their,ability
R2432 T3628 T3609 nsubjpass ability,tested
R2433 T3629 T3630 aux to,survive
R2434 T3630 T3628 acl survive,ability
R2435 T3631 T3630 prep on,survive
R2436 T3632 T3633 amod solid,chow
R2437 T3633 T3631 pobj chow,on
R2438 T3634 T3609 auxpass was,tested
R2439 T3635 T3609 punct .,tested
R2440 T3637 T3638 nsubjpass Mice,maintained
R2441 T3639 T3638 auxpass were,maintained
R2442 T3640 T3638 prep on,maintained
R2443 T3641 T3642 det the,diet
R2444 T3642 T3640 pobj diet,on
R2445 T3643 T3642 compound liquid,diet
R2446 T3644 T3638 prep until,maintained
R2447 T3645 T3646 nummod 8,weeks
R2448 T3646 T3644 pobj weeks,until
R2449 T3647 T3646 prep of,weeks
R2450 T3648 T3647 pobj age,of
R2451 T3649 T3638 punct ", ",maintained
R2452 T3650 T3638 cc and,maintained
R2453 T3651 T3650 advmod then,and
R2454 T3652 T3638 conj switched,maintained
R2455 T3653 T3652 prep to,switched
R2456 T3654 T3655 amod solid,chow
R2457 T3655 T3653 pobj chow,to
R2458 T3656 T3652 prep for,switched
R2459 T3657 T3658 quantmod up,eight
R2460 T3658 T3660 nummod eight,weeks
R2461 T3659 T3658 quantmod to,eight
R2462 T3660 T3656 pobj weeks,for
R2463 T3661 T3638 punct .,maintained
R2464 T3663 T3664 mark As,shown
R2465 T3664 T3665 advcl shown,had
R2466 T3666 T3664 prep in,shown
R2467 T3667 T3666 pobj Fig.,in
R2468 T3668 T3667 nummod 4,Fig.
R2469 T3669 T3665 punct ", ",had
R2470 T3670 T3671 amod wild,type
R2471 T3671 T3672 compound type,mice
R2472 T3672 T3665 nsubj mice,had
R2473 T3673 T3674 nummod 100,%
R2474 T3674 T3675 compound %,survival
R2475 T3675 T3665 dobj survival,had
R2476 T3676 T3665 prep on,had
R2477 T3677 T3676 pobj chow,on
R2478 T3678 T3665 punct ", ",had
R2479 T3679 T3680 mark as,expected
R2480 T3680 T3665 advcl expected,had
R2481 T3681 T3665 punct .,had
R2482 T3683 T3684 det The,majority
R2483 T3684 T3685 nsubj majority,died
R2484 T3686 T3684 prep of,majority
R2485 T3687 T3688 compound CF,mice
R2486 T3688 T3686 pobj mice,of
R2487 T3689 T3688 prep on,mice
R2488 T3690 T3691 det the,background
R2489 T3691 T3689 pobj background,on
R2490 T3692 T3691 compound B6,background
R2491 T3693 T3685 prep within,died
R2492 T3694 T3695 quantmod 2,3
R2493 T3695 T3697 nummod 3,weeks
R2494 T3696 T3695 punct –,3
R2495 T3697 T3693 pobj weeks,within
R2496 T3698 T3685 prep on,died
R2497 T3699 T3700 amod solid,chow
R2498 T3700 T3698 pobj chow,on
R2499 T3701 T3685 punct ", ",died
R2500 T3702 T3685 prep with,died
R2501 T3703 T3704 advmod about,60
R2502 T3704 T3705 nummod 60,%
R2503 T3705 T3706 compound %,mortality
R2504 T3706 T3702 pobj mortality,with
R2505 T3707 T3706 prep over,mortality
R2506 T3708 T3709 det the,period
R2507 T3709 T3707 pobj period,over
R2508 T3710 T3711 nummod 8,week
R2509 T3711 T3709 compound week,period
R2510 T3712 T3685 punct .,died
R2511 T3714 T3715 prep In,died
R2512 T3716 T3714 pobj contrast,In
R2513 T3717 T3715 punct ", ",died
R2514 T3718 T3719 advmod only,22
R2515 T3719 T3720 nummod 22,%
R2516 T3720 T3715 nsubj %,died
R2517 T3721 T3720 prep of,%
R2518 T3722 T3723 det the,mice
R2519 T3723 T3721 pobj mice,of
R2520 T3724 T3723 compound CF,mice
R2521 T3725 T3723 prep on,mice
R2522 T3726 T3727 det the,background
R2523 T3727 T3725 pobj background,on
R2524 T3728 T3727 amod mixed,background
R2525 T3729 T3730 punct (,Fig.
R2526 T3730 T3715 parataxis Fig.,died
R2527 T3731 T3730 nummod 4,Fig.
R2528 T3732 T3730 punct ),Fig.
R2529 T3733 T3715 punct .,died
R2535 T4293 T4292 prep of,Identification
R2536 T4294 T4295 amod potential,loci
R2537 T4295 T4293 pobj loci,of
R2538 T4296 T4295 compound modifier,loci
R2539 T4298 T4299 aux To,determine
R2540 T4299 T4300 advcl determine,analyzed
R2541 T4301 T4302 det the,contributions
R2542 T4302 T4299 dobj contributions,determine
R2543 T4303 T4302 prep of,contributions
R2544 T4304 T4305 nmod B6,alleles
R2545 T4305 T4303 pobj alleles,of
R2546 T4306 T4304 cc and,B6
R2547 T4307 T4304 conj 129,B6
R2548 T4308 T4302 prep to,contributions
R2549 T4309 T4310 det the,background
R2550 T4310 T4308 pobj background,to
R2551 T4311 T4310 amod mixed,background
R2552 T4312 T4310 amod genetic,background
R2553 T4313 T4299 punct ", ",determine
R2554 T4314 T4299 cc and,determine
R2555 T4315 T4316 aux to,identify
R2556 T4316 T4299 conj identify,determine
R2557 T4317 T4318 amod potential,regions
R2558 T4318 T4316 dobj regions,identify
R2559 T4319 T4318 compound modifier,regions
R2560 T4320 T4300 punct ", ",analyzed
R2561 T4321 T4322 compound tail,DNA
R2562 T4322 T4300 nsubjpass DNA,analyzed
R2563 T4323 T4300 auxpass was,analyzed
R2564 T4324 T4300 prep by,analyzed
R2565 T4325 T4324 pobj PCR,by
R2566 T4326 T4300 prep for,analyzed
R2567 T4327 T4326 pobj markers,for
R2568 T4328 T4327 prep of,markers
R2569 T4329 T4328 pobj polymorphisms,of
R2570 T4330 T4329 prep between,polymorphisms
R2571 T4331 T4332 det these,strains
R2572 T4332 T4330 pobj strains,between
R2573 T4333 T4332 nummod two,strains
R2574 T4334 T4332 compound mouse,strains
R2575 T4335 T4300 punct .,analyzed
R2576 T4337 T4338 nsubjpass Mice,analyzed
R2577 T4339 T4337 amod congenic,Mice
R2578 T4340 T4339 prep on,congenic
R2579 T4341 T4342 det the,background
R2580 T4342 T4340 pobj background,on
R2581 T4343 T4342 compound B6,background
R2582 T4344 T4337 punct ", ",Mice
R2583 T4345 T4346 dep which,derived
R2584 T4346 T4337 relcl derived,Mice
R2585 T4347 T4346 auxpass were,derived
R2586 T4348 T4346 prep from,derived
R2587 T4349 T4348 pobj mice,from
R2588 T4350 T4351 advmod originally,on
R2589 T4351 T4349 prep on,mice
R2590 T4352 T4353 det a,background
R2591 T4353 T4351 pobj background,on
R2592 T4354 T4353 nmod B6,background
R2593 T4355 T4354 punct /,B6
R2594 T4356 T4354 nummod 129,B6
R2595 T4357 T4353 amod mixed,background
R2596 T4358 T4338 punct ", ",analyzed
R2597 T4359 T4338 auxpass were,analyzed
R2598 T4360 T4338 advmod also,analyzed
R2599 T4361 T4362 aux to,confirm
R2600 T4362 T4338 advcl confirm,analyzed
R2601 T4363 T4364 nsubj they,are
R2602 T4364 T4362 advcl are,confirm
R2603 T4365 T4366 amod congenic,B6
R2604 T4366 T4364 attr B6,are
R2605 T4367 T4338 punct .,analyzed
R2606 T4369 T4370 nummod Twelve,mice
R2607 T4370 T4372 nsubj mice,averaged
R2608 T4371 T4370 compound CF,mice
R2609 T4373 T4370 prep on,mice
R2610 T4374 T4375 det the,background
R2611 T4375 T4373 pobj background,on
R2612 T4376 T4375 compound B6,background
R2613 T4377 T4378 nummod 99.5,%
R2614 T4378 T4379 compound %,alleles
R2615 T4379 T4372 dobj alleles,averaged
R2616 T4380 T4379 compound B6,alleles
R2617 T4381 T4372 punct .,averaged
R2618 T4383 T4384 nsubj One,had
R2619 T4385 T4383 prep of,One
R2620 T4386 T4387 det the,mice
R2621 T4387 T4385 pobj mice,of
R2622 T4388 T4387 nummod twelve,mice
R2623 T4389 T4384 dobj alleles,had
R2624 T4390 T4389 prep from,alleles
R2625 T4391 T4392 det both,strains
R2626 T4392 T4390 pobj strains,from
R2627 T4393 T4384 prep at,had
R2628 T4394 T4393 pobj chr.9,at
R2629 T4395 T4394 punct ", ",chr.9
R2630 T4396 T4397 nummod 40,cM
R2631 T4397 T4394 npadvmod cM,chr.9
R2632 T4398 T4384 punct .,had
R2633 T4400 T4401 det All,mice
R2634 T4401 T4403 nsubj mice,had
R2635 T4402 T4401 nummod twelve,mice
R2636 T4404 T4405 preconj both,B6
R2637 T4405 T4406 nmod B6,markers
R2638 T4406 T4403 dobj markers,had
R2639 T4407 T4405 cc and,B6
R2640 T4408 T4405 conj 129,B6
R2641 T4409 T4403 prep on,had
R2642 T4410 T4409 pobj chromosome,on
R2643 T4411 T4410 nummod 6,chromosome
R2644 T4412 T4410 punct ", ",chromosome
R2645 T4413 T4414 nummod 1,cM
R2646 T4414 T4410 npadvmod cM,chromosome
R2647 T4415 T4416 dep which,is
R2648 T4416 T4403 advcl is,had
R2649 T4417 T4416 advmod probably,is
R2650 T4418 T4416 prep due,is
R2651 T4419 T4418 pcomp to,due
R2652 T4420 T4421 det the,gene
R2653 T4421 T4418 pobj gene,due
R2654 T4422 T4421 amod targeted,gene
R2655 T4423 T4421 compound Cftr,gene
R2656 T4424 T4425 dep which,is
R2657 T4425 T4421 relcl is,gene
R2658 T4426 T4425 prep at,is
R2659 T4427 T4426 pobj chr.6,at
R2660 T4428 T4427 punct ", ",chr.6
R2661 T4429 T4430 nummod 3.1,cM
R2662 T4430 T4427 npadvmod cM,chr.6
R2663 T4431 T4432 punct [,36
R2664 T4432 T4403 parataxis 36,had
R2665 T4433 T4432 punct ],36
R2666 T4434 T4403 punct .,had
R2667 T4436 T4437 nummod Three,mice
R2668 T4437 T4439 nsubjpass mice,analyzed
R2669 T4438 T4437 compound CF,mice
R2670 T4440 T4437 prep on,mice
R2671 T4441 T4442 det the,background
R2672 T4442 T4440 pobj background,on
R2673 T4443 T4442 amod mixed,background
R2674 T4444 T4439 auxpass were,analyzed
R2675 T4445 T4439 advmod initially,analyzed
R2676 T4446 T4439 cc and,analyzed
R2677 T4447 T4448 auxpass were,found
R2678 T4448 T4439 conj found,analyzed
R2679 T4449 T4450 aux to,be
R2680 T4450 T4448 xcomp be,found
R2681 T4451 T4452 nummod 95,%
R2682 T4452 T4453 compound %,B6
R2683 T4453 T4450 attr B6,be
R2684 T4454 T4453 punct ", ",B6
R2685 T4455 T4456 nummod 5,%
R2686 T4456 T4453 appos %,B6
R2687 T4457 T4456 nummod 129,%
R2688 T4458 T4439 punct .,analyzed
R2689 T4460 T4461 det A,group
R2690 T4461 T4463 nsubjpass group,analyzed
R2691 T4462 T4461 amod second,group
R2692 T4464 T4461 prep of,group
R2693 T4465 T4466 nummod 8,mice
R2694 T4466 T4464 pobj mice,of
R2695 T4467 T4466 compound CF,mice
R2696 T4468 T4463 auxpass was,analyzed
R2697 T4469 T4463 cc and,analyzed
R2698 T4470 T4471 det the,markers
R2699 T4471 T4472 nsubjpass markers,refined
R2700 T4472 T4463 conj refined,analyzed
R2701 T4473 T4471 acl used,markers
R2702 T4474 T4472 auxpass were,refined
R2703 T4475 T4476 aux to,focus
R2704 T4476 T4472 advcl focus,refined
R2705 T4477 T4476 prep on,focus
R2706 T4478 T4479 det the,regions
R2707 T4479 T4477 pobj regions,on
R2708 T4480 T4479 amod chromosomal,regions
R2709 T4481 T4479 acl showing,regions
R2710 T4482 T4481 dobj variations,showing
R2711 T4483 T4482 prep from,variations
R2712 T4484 T4485 det the,strain
R2713 T4485 T4483 pobj strain,from
R2714 T4486 T4485 compound B6,strain
R2715 T4487 T4472 punct .,refined
R2716 T4489 T4490 det The,differences
R2717 T4490 T4491 nsubjpass differences,combined
R2718 T4492 T4490 acl found,differences
R2719 T4493 T4492 prep from,found
R2720 T4494 T4495 det the,analyses
R2721 T4495 T4493 pobj analyses,from
R2722 T4496 T4495 nummod two,analyses
R2723 T4497 T4491 auxpass are,combined
R2724 T4498 T4491 prep in,combined
R2725 T4499 T4498 pobj Table,in
R2726 T4500 T4499 nummod 3,Table
R2727 T4501 T4491 punct .,combined
R2728 T4503 T4504 det The,differences
R2729 T4504 T4505 nsubj differences,were
R2730 T4506 T4504 prep in,differences
R2731 T4507 T4508 det the,mice
R2732 T4508 T4506 pobj mice,in
R2733 T4509 T4510 amod mixed,strain
R2734 T4510 T4508 compound strain,mice
R2735 T4511 T4508 compound CF,mice
R2736 T4512 T4505 prep at,were
R2737 T4513 T4512 pobj chr.1,at
R2738 T4514 T4513 punct ", ",chr.1
R2739 T4515 T4516 nummod 92,cM
R2740 T4516 T4513 npadvmod cM,chr.1
R2741 T4517 T4518 punct (,had
R2742 T4518 T4513 parataxis had,chr.1
R2743 T4519 T4520 quantmod 9,11
R2744 T4520 T4522 nummod 11,mice
R2745 T4521 T4520 quantmod of,11
R2746 T4522 T4518 nsubj mice,had
R2747 T4523 T4524 preconj both,B6
R2748 T4524 T4525 nmod B6,alleles
R2749 T4525 T4518 dobj alleles,had
R2750 T4526 T4524 cc and,B6
R2751 T4527 T4524 conj 129,B6
R2752 T4528 T4518 punct ),had
R2753 T4529 T4513 punct ;,chr.1
R2754 T4530 T4513 conj chr.9,chr.1
R2755 T4531 T4530 punct ", ",chr.9
R2756 T4532 T4533 nummod 9,cM
R2757 T4533 T4530 npadvmod cM,chr.9
R2758 T4534 T4535 punct (,had
R2759 T4535 T4530 parataxis had,chr.9
R2760 T4536 T4537 det all,mice
R2761 T4537 T4535 nsubj mice,had
R2762 T4538 T4537 nummod 11,mice
R2763 T4539 T4540 nummod two,alleles
R2764 T4540 T4535 dobj alleles,had
R2765 T4541 T4540 nummod 129,alleles
R2766 T4542 T4535 punct ),had
R2767 T4543 T4530 punct ;,chr.9
R2768 T4544 T4530 cc and,chr.9
R2769 T4545 T4530 conj chr.10,chr.9
R2770 T4546 T4545 punct ", ",chr.10
R2771 T4547 T4548 nummod 65,cM
R2806 T4595 T4593 pobj side,on
R2807 T4596 T4595 prep of,side
R2808 T4597 T4598 det the,markers
R2809 T4598 T4596 pobj markers,of
R2810 T4599 T4581 auxpass were,looked
R2811 T4600 T4581 prep at,looked
R2812 T4601 T4581 prep for,looked
R2813 T4602 T4603 amod potential,relevance
R2814 T4603 T4601 pobj relevance,for
R2815 T4604 T4603 prep to,relevance
R2816 T4605 T4606 det the,phenotype
R2817 T4606 T4604 pobj phenotype,to
R2818 T4607 T4606 amod milder,phenotype
R2819 T4608 T4606 nmod CF,phenotype
R2820 T4609 T4606 amod intestinal,phenotype
R2821 T4610 T4581 punct .,looked
R2822 T4612 T4613 nsubj None,are
R2823 T4614 T4612 prep of,None
R2824 T4615 T4616 det the,channels
R2825 T4616 T4614 pobj channels,of
R2826 T4617 T4616 amod known,channels
R2827 T4618 T4616 compound chloride,channels
R2828 T4619 T4620 dep that,substitute
R2829 T4620 T4616 relcl substitute,channels
R2830 T4621 T4620 aux might,substitute
R2831 T4622 T4620 prep for,substitute
R2832 T4623 T4624 det the,CFTR
R2833 T4624 T4622 pobj CFTR,for
R2834 T4625 T4624 amod missing,CFTR
R2835 T4626 T4613 prep in,are
R2836 T4627 T4628 det the,regions
R2837 T4628 T4626 pobj regions,in
R2838 T4629 T4628 prep of,regions
R2839 T4630 T4631 det the,chromosomes
R2840 T4631 T4629 pobj chromosomes,of
R2841 T4632 T4631 nummod three,chromosomes
R2842 T4633 T4631 acl associated,chromosomes
R2843 T4634 T4633 prep with,associated
R2844 T4635 T4636 det the,phenotype
R2845 T4636 T4634 pobj phenotype,with
R2846 T4637 T4636 amod milder,phenotype
R2847 T4638 T4613 punct .,are
R2848 T4640 T4641 expl There,are
R2849 T4642 T4643 amod several,genes
R2850 T4643 T4641 attr genes,are
R2851 T4644 T4643 compound potassium,genes
R2852 T4645 T4643 compound channel,genes
R2853 T4646 T4643 prep in,genes
R2854 T4647 T4648 det the,regions
R2855 T4648 T4646 pobj regions,in
R2856 T4649 T4648 amod identified,regions
R2857 T4650 T4651 dep that,affect
R2858 T4651 T4643 relcl affect,genes
R2859 T4652 T4651 advmod potentially,affect
R2860 T4653 T4651 aux could,affect
R2861 T4654 T4655 nmod electrolyte,transport
R2862 T4655 T4651 dobj transport,affect
R2863 T4656 T4654 cc and,electrolyte
R2864 T4657 T4654 conj fluid,electrolyte
R2865 T4658 T4643 punct : ,genes
R2866 T4659 T4643 appos Kcnj9,genes
R2867 T4660 T4661 punct (,chr.1
R2868 T4661 T4659 parataxis chr.1,Kcnj9
R2869 T4662 T4661 punct ", ",chr.1
R2870 T4663 T4664 nummod 94.2,cM
R2871 T4664 T4661 npadvmod cM,chr.1
R2872 T4665 T4661 punct ),chr.1
R2873 T4666 T4659 punct ", ",Kcnj9
R2874 T4667 T4659 conj Kcnj10,Kcnj9
R2875 T4668 T4669 punct (,chr.1
R2876 T4669 T4667 parataxis chr.1,Kcnj10
R2877 T4670 T4669 punct ", ",chr.1
R2878 T4671 T4672 nummod 93.5,cM
R2879 T4672 T4669 npadvmod cM,chr.1
R2880 T4673 T4669 punct ),chr.1
R2881 T4674 T4667 punct ", ",Kcnj10
R2882 T4675 T4667 conj Kcnj5,Kcnj10
R2883 T4676 T4677 punct (,cM
R2884 T4677 T4675 parataxis cM,Kcnj5
R2885 T4678 T4677 dep chr.9,cM
R2886 T4679 T4677 punct ", ",cM
R2887 T4680 T4677 nummod 11,cM
R2888 T4681 T4677 punct ),cM
R2889 T4682 T4675 punct ", ",Kcnj5
R2890 T4683 T4675 cc and,Kcnj5
R2891 T4684 T4675 conj Kcnc2,Kcnj5
R2892 T4685 T4686 punct (,chr.10
R2893 T4686 T4684 parataxis chr.10,Kcnc2
R2894 T4687 T4686 punct ", ",chr.10
R2895 T4688 T4689 nummod 62,cM
R2896 T4689 T4686 npadvmod cM,chr.10
R2897 T4690 T4686 punct ),chr.10
R2898 T4691 T4641 punct .,are
R2899 T4693 T4694 det All,names
R2900 T4694 T4696 nsubj names,are
R2901 T4695 T4694 compound gene,names
R2902 T4697 T4696 prep from,are
R2903 T4698 T4699 det the,website
R2904 T4699 T4697 pobj website,from
R2905 T4700 T4701 compound Mouse,Informatics
R2906 T4701 T4699 compound Informatics,website
R2907 T4702 T4701 compound Genome,Informatics
R2908 T4703 T4696 punct .,are
R2909 T4705 T4706 nsubj Inflammation,is
R2910 T4707 T4708 det a,hallmark
R2911 T4708 T4706 attr hallmark,is
R2912 T4709 T4708 prep of,hallmark
R2913 T4710 T4709 pobj CF,of
R2914 T4711 T4706 punct ", ",is
R2915 T4712 T4706 cc and,is
R2916 T4713 T4714 mark whether,is
R2917 T4714 T4716 csubj is,is
R2918 T4715 T4714 expl there,is
R2919 T4716 T4706 conj is,is
R2920 T4717 T4718 det an,defect
R2921 T4718 T4714 attr defect,is
R2922 T4719 T4718 amod inherent,defect
R2923 T4720 T4718 prep in,defect
R2924 T4721 T4720 pobj CF,in
R2925 T4722 T4723 dep that,predisposes
R2926 T4723 T4718 relcl predisposes,defect
R2927 T4724 T4723 prep to,predisposes
R2928 T4725 T4726 amod excessive,inflammation
R2929 T4726 T4724 pobj inflammation,to
R2930 T4727 T4716 acomp controversial,is
R2931 T4728 T4716 punct .,is
R2932 T4730 T4731 amod Several,genes
R2933 T4731 T4732 nsubjpass genes,located
R2934 T4733 T4731 acl involved,genes
R2935 T4734 T4733 prep in,involved
R2936 T4735 T4734 pobj inflammation,in
R2937 T4736 T4735 cc and,inflammation
R2938 T4737 T4738 det the,system
R2939 T4738 T4735 conj system,inflammation
R2940 T4739 T4738 amod immune,system
R2941 T4740 T4732 auxpass are,located
R2942 T4741 T4732 prep in,located
R2943 T4742 T4743 det the,regions
R2944 T4743 T4741 pobj regions,in
R2945 T4744 T4743 prep of,regions
R2946 T4745 T4746 det the,markers
R2947 T4746 T4744 pobj markers,of
R2948 T4747 T4746 acl identified,markers
R2949 T4748 T4746 punct : ,markers
R2950 T4749 T4750 compound TNF,Tnfsf4
R2951 T4750 T4746 appos Tnfsf4,markers
R2952 T4751 T4750 compound superfamily,Tnfsf4
R2953 T4752 T4750 compound members,Tnfsf4
R2954 T4753 T4750 punct ", ",Tnfsf4
R2955 T4754 T4750 nummod 6,Tnfsf4
R2956 T4755 T4750 punct ", ",Tnfsf4
R2957 T4756 T4750 cc and,Tnfsf4
R2958 T4757 T4750 conj 8,Tnfsf4
R2959 T4758 T4759 punct (,chr.1
R2960 T4759 T4750 parataxis chr.1,Tnfsf4
R2961 T4760 T4759 punct ", ",chr.1
R2962 T4761 T4762 quantmod 84.9,85
R2963 T4762 T4764 nummod 85,cM
R2964 T4763 T4762 punct –,85
R2965 T4764 T4759 npadvmod cM,chr.1
R2966 T4765 T4759 punct ),chr.1
R2967 T4766 T4767 dep which,involved
R2968 T4767 T4750 relcl involved,Tnfsf4
R2969 T4768 T4767 auxpass are,involved
R2970 T4769 T4767 prep in,involved
R2971 T4770 T4771 compound T,cell
R2972 T4771 T4772 compound cell,activation
R2973 T4772 T4769 pobj activation,in
R2974 T4773 T4774 punct [,38
R2975 T4774 T4750 parataxis 38,Tnfsf4
R2976 T4775 T4774 nummod 37,38
R2977 T4776 T4774 punct ",",38
R2978 T4777 T4774 punct ],38
R2979 T4778 T4750 punct ;,Tnfsf4
R2980 T4779 T4780 nummod three,genes
R2981 T4780 T4750 conj genes,Tnfsf4
R2982 T4781 T4780 compound selectin,genes
R2983 T4782 T4783 punct (,chr.1
R2984 T4783 T4780 parataxis chr.1,genes
R2985 T4784 T4783 dep Sele,chr.1
R2986 T4785 T4784 punct ", ",Sele
R2987 T4786 T4784 appos Sell,Sele
R2988 T4787 T4784 punct ", ",Sele
R2989 T4788 T4784 appos Selp,Sele
R2990 T4789 T4783 punct ", ",chr.1
R2991 T4790 T4783 punct ", ",chr.1
R2992 T4791 T4792 nummod 86.6,cM
R2993 T4792 T4783 npadvmod cM,chr.1
R2994 T4793 T4783 punct ),chr.1
R2995 T4794 T4795 dep which,involved
R2996 T4795 T4780 relcl involved,genes
R2997 T4796 T4795 auxpass are,involved
R2998 T4797 T4795 prep in,involved
R2999 T4798 T4799 amod immune,cell
R3000 T4799 T4800 compound cell,infiltration
R3001 T4800 T4797 pobj infiltration,in
R3002 T4801 T4800 prep into,infiltration
R3003 T4802 T4803 amod inflamed,tissues
R3004 T4803 T4801 pobj tissues,into
R3005 T4804 T4805 punct [,39
R3006 T4805 T4780 parataxis 39,genes
R3007 T4806 T4805 punct ],39
R3008 T4807 T4780 punct ;,genes
R3009 T4808 T4809 amod several,members
R3010 T4809 T4780 conj members,genes
R3011 T4810 T4809 prep of,members
R3012 T4811 T4812 amod immune,cell
R3013 T4812 T4813 compound cell,proteins
R3014 T4813 T4810 pobj proteins,of
R3015 T4814 T4813 compound surface,proteins
R3016 T4815 T4813 prep of,proteins
R3017 T4816 T4817 det the,family
R3018 T4817 T4815 pobj family,of
R3019 T4818 T4817 compound Slam,family
R3020 T4819 T4820 punct (,chr.1
R3021 T4820 T4813 parataxis chr.1,proteins
R3022 T4821 T4820 dep slamf1,chr.1
R3023 T4822 T4821 punct ", ",slamf1
R3024 T4823 T4821 nummod 2,slamf1
R3025 T4824 T4821 punct ", ",slamf1
R3026 T4825 T4821 nummod 5,slamf1
R3027 T4826 T4821 punct ", ",slamf1
R3028 T4827 T4821 nummod 6,slamf1
R3029 T4828 T4821 punct ", ",slamf1
R3030 T4829 T4821 cc and,slamf1
R3031 T4830 T4821 conj 9,slamf1
R3032 T4831 T4820 punct ;,chr.1
R3033 T4832 T4820 punct ", ",chr.1
R3034 T4833 T4834 quantmod 89.5,93.3
R3035 T4834 T4836 nummod 93.3,cM
R3036 T4835 T4834 punct –,93.3
R3037 T4836 T4820 npadvmod cM,chr.1
R3038 T4837 T4820 punct ),chr.1
R3039 T4838 T4839 punct [,40
R3040 T4839 T4809 parataxis 40,members
R3041 T4840 T4839 punct ],40
R3042 T4841 T4809 punct ;,members
R3043 T4842 T4843 det the,gene
R3044 T4843 T4809 conj gene,members
R3045 T4844 T4843 compound chemokine,gene
R3046 T4845 T4843 appos Xcl1,gene
R3047 T4846 T4847 punct (,chr.1
R3048 T4847 T4843 parataxis chr.1,gene
R3049 T4848 T4847 punct ", ",chr.1
R3050 T4849 T4850 nummod 87,cM
R3051 T4850 T4847 npadvmod cM,chr.1
R3052 T4851 T4847 punct ),chr.1
R3053 T4852 T4853 dep which,expressed
R3054 T4853 T4843 relcl expressed,gene
R3055 T4854 T4853 auxpass is,expressed
R3056 T4855 T4853 agent by,expressed
R3057 T4856 T4857 compound mast,cells
R3058 T4857 T4855 pobj cells,by
R3059 T4858 T4857 cc and,cells
R3060 T4859 T4860 nmod recruits,lymphocytes
R3061 T4860 T4857 conj lymphocytes,cells
R3062 T4861 T4862 punct [,41
R3063 T4862 T4843 parataxis 41,gene
R3064 T4863 T4862 punct ],41
R3065 T4864 T4843 punct ;,gene
R3066 T4865 T4866 amod several,genes
R3067 T4866 T4843 conj genes,gene
R3068 T4867 T4868 compound immunoglobulin,receptor
R3069 T4868 T4866 compound receptor,genes
R3070 T4869 T4868 compound Fc,receptor
R3071 T4870 T4871 punct (,Fcrl3
R3072 T4871 T4866 parataxis Fcrl3,genes
R3073 T4872 T4871 punct ", ",Fcrl3
R3074 T4873 T4871 conj Fcgr2b,Fcrl3
R3075 T4874 T4873 punct ", ",Fcgr2b
R3076 T4875 T4873 cc and,Fcgr2b
R3077 T4876 T4873 conj Fcgr3,Fcgr2b
R3078 T4877 T4871 prep at,Fcrl3
R3079 T4878 T4877 pobj chr.1,at
R3080 T4879 T4878 punct ", ",chr.1
R3081 T4880 T4881 nummod 92.3,cM
R3082 T4881 T4878 npadvmod cM,chr.1
R3083 T4882 T4871 punct ;,Fcrl3
R3084 T4883 T4871 appos Fcer1g,Fcrl3
R3085 T4884 T4883 prep at,Fcer1g
R3086 T4885 T4884 pobj chr.1,at
R3087 T4886 T4885 punct ", ",chr.1
R3088 T4887 T4888 nummod 93.3,cM
R3089 T4888 T4885 npadvmod cM,chr.1
R3090 T4889 T4871 punct ;,Fcrl3
R3091 T4890 T4871 appos Fcer1a,Fcrl3
R3092 T4891 T4890 prep at,Fcer1a
R3093 T4892 T4891 pobj chr.1,at
R3094 T4893 T4892 punct ", ",chr.1
R3095 T4894 T4895 nummod 94.2,cM
R3096 T4895 T4892 npadvmod cM,chr.1
R3097 T4896 T4871 punct ),Fcrl3
R3098 T4897 T4866 punct ;,genes
R3099 T4898 T4899 det the,receptor
R3100 T4899 T4866 conj receptor,genes
R3101 T4900 T4899 compound flagellin,receptor
R3102 T4901 T4899 appos Tlr5,receptor
R3103 T4902 T4903 punct (,chr.1
R3104 T4903 T4899 parataxis chr.1,receptor
R3105 T4904 T4903 punct ", ",chr.1
R3106 T4905 T4906 nummod 98,cM
R3107 T4906 T4903 npadvmod cM,chr.1
R3108 T4907 T4903 punct ),chr.1
R3109 T4908 T4899 punct ;,receptor
R3110 T4909 T4899 conj Mmp3,receptor
R3111 T4910 T4911 punct (,chr.9
R3112 T4911 T4909 parataxis chr.9,Mmp3
R3113 T4912 T4911 punct ", ",chr.9
R3114 T4913 T4914 nummod 1,cM
R3115 T4914 T4911 npadvmod cM,chr.9
R3116 T4915 T4911 punct ),chr.9
R3117 T4916 T4917 dep which,recruits
R3118 T4917 T4909 relcl recruits,Mmp3
R3119 T4918 T4919 nmod CD4,lymphocytes
R3120 T4919 T4917 dobj lymphocytes,recruits
R3121 T4920 T4918 punct +,CD4
R3122 T4921 T4922 punct [,42
R3123 T4922 T4909 parataxis 42,Mmp3
R3124 T4923 T4922 punct ],42
R3125 T4924 T4909 punct ;,Mmp3
R3126 T4925 T4909 conj Mmp7,Mmp3
R3127 T4926 T4927 punct (,chr.9
R3128 T4927 T4925 parataxis chr.9,Mmp7
R3129 T4928 T4927 punct ", ",chr.9
R3130 T4929 T4930 nummod 1,cM
R3131 T4930 T4927 npadvmod cM,chr.9
R3132 T4931 T4927 punct ),chr.9
R3133 T4932 T4933 dep which,activates
R3134 T4933 T4925 relcl activates,Mmp7
R3135 T4934 T4935 compound Paneth,cell
R3136 T4935 T4936 npadvmod cell,derived
R3137 T4936 T4938 amod derived,cryptdins
R3138 T4937 T4936 punct -,derived
R3139 T4938 T4933 dobj cryptdins,activates
R3140 T4939 T4938 punct (,cryptdins
R3141 T4940 T4941 compound α,defensins
R3142 T4941 T4938 appos defensins,cryptdins
R3143 T4942 T4941 punct -,defensins
R3144 T4943 T4925 punct ),Mmp7
R3145 T4944 T4945 punct [,43
R3146 T4945 T4925 parataxis 43,Mmp7
R3147 T4946 T4945 punct ],43
R3148 T4947 T4925 punct ;,Mmp7
R3149 T4948 T4925 conj Icam1,Mmp7
R3150 T4949 T4950 punct (,chr.9
R3151 T4950 T4948 parataxis chr.9,Icam1
R3152 T4951 T4950 punct ", ",chr.9
R3153 T4952 T4953 nummod 7,cM
R3154 T4953 T4950 npadvmod cM,chr.9
R3155 T4954 T4950 punct ),chr.9
R3156 T4955 T4956 dep which,involved
R3157 T4956 T4948 relcl involved,Icam1
R3158 T4957 T4956 auxpass is,involved
R3159 T4958 T4956 prep in,involved
R3160 T4959 T4960 compound lymphocyte,infiltration
R3161 T4960 T4958 pobj infiltration,in
R3162 T4961 T4960 prep into,infiltration
R3163 T4962 T4963 amod inflamed,tissues
R3164 T4963 T4961 pobj tissues,into
R3165 T4964 T4965 punct [,44
R3166 T4965 T4948 parataxis 44,Icam1
R3167 T4966 T4965 punct ],44
R3168 T4967 T4948 punct ;,Icam1
R3169 T4968 T4948 conj Kitl,Icam1
R3170 T4969 T4970 punct (,chr.10
R3171 T4970 T4968 parataxis chr.10,Kitl
R3172 T4971 T4970 punct ", ",chr.10
R3173 T4972 T4973 nummod 57,cM
R3174 T4973 T4970 npadvmod cM,chr.10
R3175 T4974 T4970 punct ),chr.10
R3176 T4975 T4976 dep which,known
R3177 T4976 T4968 relcl known,Kitl
R3178 T4977 T4976 auxpass is,known
R3179 T4978 T4976 advmod also,known
R3180 T4979 T4976 prep as,known
R3181 T4980 T4981 compound stem,cell
R3182 T4981 T4982 compound cell,factor
R3183 T4982 T4979 pobj factor,as
R3184 T4983 T4976 punct ", ",known
R3185 T4984 T4976 cc and,known
R3186 T4985 T4976 conj is,known
R3187 T4986 T4985 acomp crucial,is
R3188 T4987 T4986 prep for,crucial
R3189 T4988 T4989 compound mast,cell
R3190 T4989 T4990 compound cell,differentiation
R3191 T4990 T4987 pobj differentiation,for
R3192 T4991 T4992 punct [,45
R3193 T4992 T4968 parataxis 45,Kitl
R3194 T4993 T4992 punct ],45
R3195 T4994 T4968 punct ;,Kitl
R3196 T4995 T4968 conj Im5,Kitl
R3197 T4996 T4997 punct (,chr.10
R3198 T4997 T4995 parataxis chr.10,Im5
R3199 T4998 T4997 punct ", ",chr.10
R3200 T4999 T5000 nummod 65,cM
R3201 T5000 T4997 npadvmod cM,chr.10
R3202 T5001 T4997 punct ),chr.10
R3203 T5002 T5003 dep which,involved
R3204 T5003 T4995 relcl involved,Im5
R3205 T5004 T5003 auxpass is,involved
R3206 T5005 T5003 prep in,involved
R3207 T5006 T5007 compound antibody,responsiveness
R3208 T5007 T5005 pobj responsiveness,in
R3209 T5008 T5007 punct -,responsiveness
R3210 T5009 T5010 punct [,46
R3211 T5010 T4995 parataxis 46,Im5
R3212 T5011 T5010 punct ],46
R3213 T5012 T4995 punct ;,Im5
R3214 T5013 T4995 conj Lyzs,Im5
R3215 T5014 T5015 punct (,chr.10
R3216 T5015 T5013 parataxis chr.10,Lyzs
R3217 T5016 T5015 punct ", ",chr.10
R3218 T5017 T5018 nummod 66,cM
R3219 T5018 T5015 npadvmod cM,chr.10
R3220 T5019 T5015 punct ),chr.10
R3221 T5020 T5021 dep which,is
R3222 T5021 T5013 relcl is,Lyzs
R3223 T5022 T5023 det a,product
R3224 T5023 T5021 attr product,is
R3225 T5024 T5025 compound Paneth,cell
R3226 T5025 T5023 compound cell,product
R3227 T5026 T5027 dep that,digests
R3228 T5027 T5023 relcl digests,product
R3229 T5028 T5029 compound cell,walls
R3230 T5029 T5027 dobj walls,digests
R3231 T5030 T5029 prep of,walls
R3232 T5031 T5030 pobj bacteria,of
R3233 T5032 T5033 punct [,47
R3234 T5033 T5013 parataxis 47,Lyzs
R3235 T5034 T5033 punct ],47
R3236 T5035 T5013 punct ;,Lyzs
R3237 T5036 T5013 conj Ifng,Lyzs
R3238 T5037 T5038 punct (,chr.10
R3239 T5038 T5036 parataxis chr.10,Ifng
R3240 T5039 T5038 punct ", ",chr.10
R3241 T5040 T5041 nummod 67,cM
R3242 T5041 T5038 npadvmod cM,chr.10
R3243 T5042 T5038 punct ),chr.10
R3244 T5043 T5044 dep which,is
R3245 T5044 T5036 relcl is,Ifng
R3246 T5045 T5046 det an,signal
R3247 T5046 T5044 attr signal,is
R3248 T5047 T5046 amod important,signal
R3249 T5048 T5046 amod inflammatory,signal
R3250 T5049 T5046 prep in,signal
R3251 T5050 T5049 pobj CF,in
R3252 T5051 T5052 advmod as,as
R3253 T5052 T5050 cc as,CF
R3254 T5053 T5052 advmod well,as
R3255 T5054 T5055 amod other,conditions
R3256 T5055 T5050 conj conditions,CF
R3257 T5056 T5057 punct [,48
R3258 T5057 T5036 parataxis 48,Ifng
R3259 T5058 T5057 punct ],48
R3260 T5059 T5036 punct ;,Ifng
R3261 T5060 T5036 conj Il22,Ifng
R3262 T5061 T5062 punct (,chr.10
R3263 T5062 T5060 parataxis chr.10,Il22
R3264 T5063 T5062 punct ", ",chr.10
R3265 T5064 T5065 nummod 67,cM
R3266 T5065 T5062 npadvmod cM,chr.10
R3267 T5066 T5062 punct ),chr.10
R3268 T5067 T5060 punct ", ",Il22
R3269 T5068 T5069 det a,member
R3270 T5069 T5060 appos member,Il22
R3271 T5070 T5069 prep of,member
R3272 T5071 T5072 det the,family
R3273 T5072 T5070 pobj family,of
R3274 T5073 T5072 amod anti-inflammatory,family
R3275 T5074 T5072 nmod IL,family
R3276 T5075 T5074 punct -,IL
R3277 T5076 T5074 nummod 10,IL
R3278 T5077 T5072 compound interleukin,family
R3279 T5078 T5079 punct [,49
R3280 T5079 T5060 parataxis 49,Il22
R3281 T5080 T5079 punct ],49
R3282 T5081 T5060 punct ;,Il22
R3283 T5082 T5060 cc and,Il22
R3284 T5083 T5084 det the,genes
R3285 T5084 T5060 conj genes,Il22
R3286 T5085 T5084 nmod Stat2,genes
R3287 T5086 T5085 cc and,Stat2
R3288 T5087 T5085 conj 6,Stat2
R3289 T5088 T5089 punct (,chr.10
R3290 T5089 T5084 parataxis chr.10,genes
R3291 T5090 T5089 punct ", ",chr.10
R3292 T5091 T5092 nummod 70,cM
R3293 T5092 T5089 npadvmod cM,chr.10
R3294 T5093 T5089 punct ),chr.10
R3295 T5094 T5095 dep which,are
R3296 T5095 T5084 relcl are,genes
R3297 T5096 T5097 amod important,components
R3298 T5097 T5095 attr components,are
R3299 T5098 T5097 prep of,components
R3300 T5099 T5100 amod intracellular,pathways
R3301 T5100 T5098 pobj pathways,of
R3302 T5101 T5100 compound signaling,pathways
R3303 T5102 T5103 punct [,50
R3304 T5103 T5084 parataxis 50,genes
R3305 T5104 T5103 punct ],50
R3306 T5105 T4732 punct .,located
R3307 T5107 T5108 advmod Also,are
R3308 T5109 T5108 prep near,are
R3309 T5110 T5111 det the,markers
R3310 T5111 T5109 pobj markers,near
R3311 T5112 T5111 amod identified,markers
R3312 T5113 T5114 det a,number
R3313 T5114 T5108 nsubj number,are
R3314 T5115 T5114 prep of,number
R3315 T5116 T5115 pobj QTL,of
R3316 T5117 T5116 acl associated,QTL
R3317 T5118 T5117 prep with,associated
R3318 T5119 T5120 compound body,weight
R3319 T5120 T5118 pobj weight,with
R3320 T5121 T5114 punct : ,number
R3321 T5122 T5114 appos Cfbw1,number
R3322 T5123 T5122 punct ", ",Cfbw1
R3323 T5124 T5125 compound CF,weight
R3324 T5125 T5122 appos weight,Cfbw1
R3325 T5126 T5125 compound mouse,weight
R3326 T5127 T5125 compound body,weight
R3327 T5128 T5122 prep at,Cfbw1
R3328 T5129 T5128 pobj chr.1,at
R3329 T5130 T5129 punct ", ",chr.1
R3330 T5131 T5132 nummod 85,cM
R3331 T5132 T5129 npadvmod cM,chr.1
R3332 T5133 T5122 punct ;,Cfbw1
R3333 T5134 T5122 conj Obq9,Cfbw1
R3334 T5135 T5134 punct ", ",Obq9
R3335 T5136 T5134 appos obesity,Obq9
R3336 T5137 T5136 nummod 9,obesity
R3337 T5138 T5134 prep at,Obq9
R3338 T5139 T5138 pobj chr.1,at
R3339 T5140 T5139 punct ", ",chr.1
R3340 T5141 T5142 nummod 88,cM
R3341 T5142 T5139 npadvmod cM,chr.1
R3342 T5143 T5134 punct ;,Obq9
R3343 T5144 T5134 conj Bw8q1,Obq9
R3344 T5145 T5144 punct ", ",Bw8q1
R3345 T5146 T5147 compound body,weight
R3346 T5147 T5144 appos weight,Bw8q1
R3347 T5148 T5147 nummod 8,weight
R3348 T5149 T5144 prep at,Bw8q1
R3349 T5150 T5149 pobj chr.1,at
R3350 T5151 T5150 punct ", ",chr.1
R3351 T5152 T5153 nummod 100,cM
R3352 T5153 T5150 npadvmod cM,chr.1
R3353 T5154 T5144 punct ;,Bw8q1
R3354 T5155 T5144 conj Lbm6,Bw8q1
R3355 T5156 T5155 punct ", ",Lbm6
R3356 T5157 T5158 amod lean,mass
R3357 T5158 T5155 appos mass,Lbm6
R3358 T5159 T5158 compound body,mass
R3359 T5160 T5158 nummod 6,mass
R3360 T5161 T5155 prep at,Lbm6
R3361 T5162 T5161 pobj chr.9,at
R3362 T5163 T5162 punct ", ",chr.9
R3363 T5164 T5165 nummod 7.7,cM
R3364 T5165 T5162 npadvmod cM,chr.9
R3365 T5166 T5155 punct ;,Lbm6
R3366 T5167 T5155 conj Bwtq4,Lbm6
R3367 T5168 T5167 punct ", ",Bwtq4
R3368 T5169 T5170 compound body,weight
R3369 T5170 T5167 appos weight,Bwtq4
R3370 T5171 T5170 nummod 4,weight
R3371 T5172 T5167 prep at,Bwtq4
R3372 T5173 T5172 pobj chr.9,at
R3373 T5174 T5173 punct ", ",chr.9
R3374 T5175 T5176 nummod 8,cM
R3375 T5176 T5173 npadvmod cM,chr.9
R3376 T5177 T5167 punct ;,Bwtq4
R3377 T5178 T5167 conj Bgeq8,Bwtq4
R3378 T5179 T5178 punct ", ",Bgeq8
R3379 T5180 T5181 compound body,growth
R3380 T5181 T5178 appos growth,Bgeq8
R3381 T5182 T5181 advmod early,growth
R3382 T5183 T5181 nummod 8,growth
R3383 T5184 T5178 prep at,Bgeq8
R3384 T5185 T5184 pobj chr.10,at
R3385 T5186 T5185 punct ", ",chr.10
R3386 T5187 T5188 nummod 57,cM
R3387 T5188 T5185 npadvmod cM,chr.10
R3388 T5189 T5178 punct ;,Bgeq8
R3389 T5190 T5178 cc and,Bgeq8
R3390 T5191 T5178 conj Pbwg5,Bgeq8
R3391 T5192 T5191 punct ", ",Pbwg5
R3392 T5193 T5194 amod postnatal,growth
R3393 T5194 T5191 appos growth,Pbwg5
R3394 T5195 T5194 compound body,growth
R3395 T5196 T5194 compound weight,growth
R3396 T5197 T5194 nummod 5,growth
R3397 T5198 T5191 prep at,Pbwg5
R3398 T5199 T5198 pobj chr.10,at
R3399 T5200 T5199 punct ", ",chr.10
R3400 T5201 T5202 nummod 68,cM
R3401 T5202 T5199 npadvmod cM,chr.10
R3402 T5203 T5108 punct .,are
R3403 T5205 T5206 advmod Clearly,are
R3404 T5207 T5206 punct ", ",are
R3405 T5208 T5206 expl there,are
R3406 T5209 T5210 amod numerous,genes
R3407 T5210 T5206 attr genes,are
R3408 T5211 T5206 prep in,are
R3409 T5212 T5213 det the,regions
R3410 T5213 T5211 pobj regions,in
R3411 T5214 T5213 nummod three,regions
R3412 T5215 T5213 acl identified,regions
R3413 T5216 T5215 prep in,identified
R3414 T5217 T5218 det this,study
R3415 T5218 T5216 pobj study,in
R3416 T5219 T5206 punct .,are
R3417 T5221 T5222 mark Because,characterized
R3418 T5222 T5229 advcl characterized,are
R3419 T5223 T5224 det the,phenotype
R3420 T5224 T5222 nsubjpass phenotype,characterized
R3421 T5225 T5226 nmod CF,mouse
R3422 T5226 T5224 nmod mouse,phenotype
R3423 T5227 T5224 amod intestinal,phenotype
R3424 T5228 T5222 auxpass is,characterized
R3425 T5230 T5222 prep by,characterized
R3426 T5231 T5232 det an,response
R3427 T5232 T5230 pobj response,by
R3428 T5233 T5234 amod innate,type
R3429 T5234 T5232 nmod type,response
R3430 T5235 T5232 amod immune,response
R3431 T5236 T5222 punct ", ",characterized
R3432 T5237 T5222 prep with,characterized
R3433 T5238 T5237 pobj increases,with
R3434 T5239 T5238 prep in,increases
R3435 T5240 T5241 compound mast,cells
R3436 T5241 T5239 pobj cells,in
R3437 T5242 T5241 cc and,cells
R3438 T5243 T5241 conj neutrophils,cells
R3439 T5244 T5229 punct ", ",are
R3440 T5245 T5246 det the,genes
R3441 T5246 T5229 nsubj genes,are
R3442 T5247 T5248 dep that,affect
R3443 T5248 T5246 relcl affect,genes
R3444 T5249 T5250 det these,cells
R3445 T5250 T5248 dobj cells,affect
R3446 T5251 T5229 prep of,are
R3447 T5252 T5253 amod special,interest
R3448 T5253 T5251 pobj interest,of
R3449 T5254 T5229 punct .,are
R3450 T5256 T5257 det The,gene
R3451 T5257 T5259 nsubj gene,is
R3452 T5258 T5257 compound Kitl,gene
R3453 T5260 T5259 acomp crucial,is
R3454 T5261 T5259 prep for,is
R3455 T5262 T5261 pobj differentiation,for
R3456 T5263 T5262 prep of,differentiation
R3457 T5264 T5265 compound mast,cells
R3458 T5265 T5263 pobj cells,of
R3459 T5266 T5259 punct ", ",is
R3460 T5267 T5259 cc and,is
R3461 T5268 T5269 compound CF,mice
R3462 T5269 T5270 nsubj mice,have
R3463 T5270 T5259 conj have,is
R3464 T5271 T5269 prep on,mice
R3465 T5272 T5273 det the,background
R3466 T5273 T5271 pobj background,on
R3467 T5274 T5273 amod mixed,background
R3468 T5275 T5276 advmod much,fewer
R3469 T5276 T5277 amod fewer,cells
R3470 T5277 T5270 dobj cells,have
R3471 T5278 T5277 amod mature,cells
R3472 T5279 T5277 compound mast,cells
R3473 T5280 T5277 prep than,cells
R3474 T5281 T5280 prep on,than
R3475 T5282 T5283 det the,background
R3476 T5283 T5281 pobj background,on
R3477 T5284 T5283 compound B6,background
R3478 T5285 T5286 mark as,revealed
R3479 T5286 T5270 advcl revealed,have
R3480 T5287 T5286 prep by,revealed
R3481 T5288 T5289 amod less,expression
R3482 T5289 T5287 pobj expression,by
R3483 T5290 T5289 prep of,expression
R3484 T5291 T5290 pobj Mcpt2,of
R3485 T5292 T5270 punct .,have
R3486 T5294 T5295 advmod Similarly,are
R3487 T5296 T5295 punct ", ",are
R3488 T5297 T5295 prep for,are
R3489 T5298 T5297 pobj neutrophils,for
R3490 T5299 T5300 det the,selectins
R3491 T5300 T5295 nsubj selectins,are
R3492 T5301 T5300 cc and,selectins
R3493 T5302 T5300 conj Icam1,selectins
R3494 T5303 T5295 prep of,are
R3495 T5304 T5303 pobj interest,of
R3496 T5305 T5295 punct ", ",are
R3497 T5306 T5307 mark as,required
R3498 T5307 T5295 advcl required,are
R3499 T5308 T5309 det these,proteins
R3500 T5309 T5307 nsubjpass proteins,required
R3501 T5310 T5307 auxpass are,required
R3502 T5311 T5307 prep for,required
R3503 T5312 T5311 pobj extravasation,for
R3504 T5313 T5312 prep of,extravasation
R3505 T5314 T5313 pobj neutrophils,of
R3506 T5315 T5307 prep from,required
R3507 T5316 T5317 det the,circulation
R3508 T5317 T5315 pobj circulation,from
R3509 T5318 T5315 prep into,from
R3510 T5319 T5320 det the,tissue
R3511 T5320 T5318 pobj tissue,into
R3512 T5321 T5320 amod inflamed,tissue
R3513 T5322 T5295 punct .,are
R3514 T5324 T5325 amod Altered,responses
R3515 T5325 T5327 nsubj responses,relate
R3516 T5326 T5325 amod immune,responses
R3517 T5328 T5327 aux may,relate
R3518 T5329 T5327 advmod also,relate
R3519 T5330 T5327 prep to,relate
R3520 T5331 T5332 amod excessive,accumulation
R3521 T5332 T5330 pobj accumulation,to
R3522 T5333 T5332 compound mucus,accumulation
R3523 T5334 T5332 prep in,accumulation
R3524 T5335 T5336 det the,intestine
R3525 T5336 T5334 pobj intestine,in
R3526 T5337 T5336 compound CF,intestine
R3527 T5338 T5327 punct .,relate
R3528 T5340 T5341 nsubj It,is
R3529 T5342 T5341 acomp unclear,is
R3530 T5343 T5344 advmod why,accumulates
R3531 T5344 T5341 ccomp accumulates,is
R3532 T5345 T5344 nsubj mucus,accumulates
R3533 T5346 T5344 prep to,accumulates
R3534 T5347 T5348 amod high,levels
R3535 T5348 T5346 pobj levels,to
R3536 T5349 T5344 prep in,accumulates
R3537 T5350 T5351 compound CF,tissues
R3538 T5351 T5349 pobj tissues,in
R3539 T5352 T5341 punct .,is
R3540 T5354 T5355 prep In,be
R3541 T5356 T5354 amod part,In
R3542 T5357 T5355 nsubj it,be
R3543 T5358 T5355 aux may,be
R3544 T5359 T5355 prep due,be
R3545 T5360 T5359 pcomp to,due
R3546 T5361 T5362 amod reduced,secretion
R3547 T5362 T5359 pobj secretion,due
R3548 T5363 T5362 compound fluid,secretion
R3549 T5364 T5362 cc and,secretion
R3550 T5365 T5366 det a,environment
R3551 T5366 T5362 conj environment,secretion
R3552 T5367 T5368 advmod more,acidic
R3553 T5368 T5366 amod acidic,environment
R3554 T5369 T5366 prep in,environment
R3555 T5370 T5371 det the,lumina
R3556 T5371 T5369 pobj lumina,in
R3557 T5372 T5371 prep of,lumina
R3558 T5373 T5374 amod affected,organs
R3559 T5374 T5372 pobj organs,of
R3560 T5375 T5355 punct .,be
R3561 T5377 T5378 advmod However,is
R3562 T5379 T5378 punct ", ",is
R3563 T5380 T5378 expl there,is
R3564 T5381 T5378 advmod also,is
R3565 T5382 T5378 attr evidence,is
R3566 T5383 T5382 prep for,evidence
R3567 T5384 T5383 pobj hypersecretion,for
R3568 T5385 T5384 prep of,hypersecretion
R3569 T5386 T5385 pobj mucus,of
R3570 T5387 T5384 prep in,hypersecretion
R3571 T5388 T5387 pobj CF,in
R3572 T5389 T5390 punct [,12
R3573 T5390 T5378 parataxis 12,is
R3574 T5391 T5390 punct ],12
R3575 T5392 T5378 punct ", ",is
R3576 T5393 T5378 cc and,is
R3577 T5394 T5395 nsubj it,is
R3578 T5395 T5378 conj is,is
R3579 T5396 T5395 acomp likely,is
R3580 T5397 T5398 mark that,have
R3581 T5398 T5395 ccomp have,is
R3582 T5399 T5400 compound effector,molecules
R3583 T5400 T5398 nsubj molecules,have
R3584 T5401 T5400 acl released,molecules
R3585 T5402 T5401 agent by,released
R3586 T5403 T5404 compound mast,cells
R3587 T5404 T5402 pobj cells,by
R3588 T5405 T5404 cc and,cells
R3589 T5406 T5404 conj neutrophils,cells
R3590 T5407 T5406 punct (,neutrophils
R3591 T5408 T5409 nmod histamine,prostaglandins
R3592 T5409 T5406 appos prostaglandins,neutrophils
R3593 T5410 T5409 punct ", ",prostaglandins
R3594 T5411 T5409 nmod proteases,prostaglandins
R3595 T5412 T5409 punct ", ",prostaglandins
R3596 T5413 T5406 punct ),neutrophils
R3597 T5414 T5415 det an,role
R3598 T5415 T5398 dobj role,have
R3599 T5416 T5415 amod important,role
R3600 T5417 T5415 prep in,role
R3601 T5418 T5417 pcomp stimulating,in
R3602 T5419 T5420 compound mucus,secretion
R3603 T5420 T5418 dobj secretion,stimulating
R3604 T5421 T5395 punct .,is
R3606 T5469 T5470 det This,work
R3607 T5470 T5471 nsubj work,demonstrated
R3608 T5472 T5473 mark that,is
R3609 T5473 T5471 ccomp is,demonstrated
R3610 T5474 T5475 det the,phenotype
R3611 T5475 T5473 nsubj phenotype,is
R3612 T5476 T5475 nmod CF,phenotype
R3613 T5477 T5475 amod inflammatory,phenotype
R3614 T5478 T5479 advmod much,less
R3615 T5479 T5480 advmod less,severe
R3616 T5480 T5473 acomp severe,is
R3617 T5481 T5473 prep in,is
R3618 T5482 T5481 pobj mice,in
R3619 T5483 T5473 prep with,is
R3620 T5484 T5485 det a,contribution
R3621 T5485 T5483 pobj contribution,with
R3622 T5486 T5485 amod small,contribution
R3623 T5487 T5485 prep of,contribution
R3624 T5488 T5489 nummod 129,Sv
R3625 T5489 T5491 compound Sv,alleles
R3626 T5490 T5489 punct /,Sv
R3627 T5491 T5487 pobj alleles,of
R3628 T5492 T5471 punct .,demonstrated
R3629 T5494 T5495 det A,analysis
R3630 T5495 T5497 nsubj analysis,identified
R3631 T5496 T5495 amod preliminary,analysis
R3632 T5498 T5497 dobj regions,identified
R3633 T5499 T5498 prep on,regions
R3634 T5500 T5501 nmod chr.,1
R3635 T5501 T5499 pobj 1,on
R3636 T5502 T5501 punct ", ",1
R3637 T5503 T5501 conj 9,1
R3638 T5504 T5503 punct ", ",9
R3639 T5505 T5503 cc and,9
R3640 T5506 T5503 conj 10,9
R3641 T5507 T5498 nmod are,regions
R3642 T5508 T5509 dep that,associated
R3643 T5509 T5498 relcl associated,regions
R3644 T5510 T5509 auxpass are,associated
R3645 T5511 T5509 advmod potentially,associated
R3646 T5512 T5509 prep with,associated
R3647 T5513 T5514 det the,phenotype
R3648 T5514 T5512 pobj phenotype,with
R3649 T5515 T5514 amod milder,phenotype
R3650 T5516 T5497 punct .,identified
R3651 T5518 T5519 prep Because,are
R3652 T5520 T5518 pcomp of,Because
R3653 T5521 T5522 det the,inflammation
R3654 T5522 T5518 pobj inflammation,Because
R3655 T5523 T5522 prep of,inflammation
R3656 T5524 T5525 det the,intestine
R3657 T5525 T5523 pobj intestine,of
R3658 T5526 T5525 nmod CF,intestine
R3659 T5527 T5525 amod small,intestine
R3660 T5528 T5522 punct ", ",inflammation
R3661 T5529 T5522 cc and,inflammation
R3662 T5530 T5531 det the,effects
R3663 T5531 T5522 conj effects,inflammation
R3664 T5532 T5531 amod possible,effects
R3665 T5533 T5531 prep of,effects
R3666 T5534 T5535 amod immune,cells
R3667 T5535 T5533 pobj cells,of
R3668 T5536 T5531 prep on,effects
R3669 T5537 T5538 compound mucus,secretion
R3670 T5538 T5536 pobj secretion,on
R3671 T5539 T5519 punct ", ",are
R3672 T5540 T5541 det the,genes
R3673 T5541 T5519 nsubj genes,are
R3674 T5542 T5541 prep in,genes
R3675 T5543 T5544 det the,regions
R3676 T5544 T5542 pobj regions,in
R3677 T5545 T5544 amod identified,regions
R3678 T5546 T5547 dep which,involved
R3679 T5547 T5541 relcl involved,genes
R3680 T5548 T5547 auxpass are,involved
R3681 T5549 T5547 prep in,involved
R3682 T5550 T5551 nmod mast,cell
R3683 T5551 T5552 nmod cell,differentiation
R3684 T5552 T5549 pobj differentiation,in
R3685 T5553 T5551 cc and,cell
R3686 T5554 T5551 conj neutrophil,cell
R3687 T5555 T5552 cc and,differentiation
R3688 T5556 T5552 conj behavior,differentiation
R3689 T5557 T5519 prep of,are
R3690 T5558 T5559 amod special,interest
R3691 T5559 T5557 pobj interest,of
R3692 T5560 T5559 prep as,interest
R3693 T5561 T5562 amod potential,modifiers
R3694 T5562 T5560 pobj modifiers,as
R3695 T5563 T5562 compound CF,modifiers
R3696 T5564 T5519 punct .,are
R3697 T5566 T5567 amod Future,work
R3698 T5567 T5568 nsubj work,focus
R3699 T5569 T5568 aux should,focus
R3700 T5570 T5568 prep on,focus
R3701 T5571 T5570 pcomp narrowing,on
R3702 T5572 T5571 prt down,narrowing
R3703 T5573 T5574 det these,regions
R3704 T5574 T5571 dobj regions,narrowing
R3705 T5575 T5571 cc and,narrowing
R3706 T5576 T5571 conj determining,narrowing
R3707 T5577 T5578 mark if,are
R3708 T5578 T5576 ccomp are,determining
R3709 T5579 T5578 expl there,are
R3710 T5580 T5578 attr polymorphisms,are
R3711 T5581 T5582 dep that,affect
R3712 T5582 T5580 relcl affect,polymorphisms
R3713 T5583 T5582 dobj expression,affect
R3714 T5584 T5583 prep of,expression
R3715 T5585 T5586 amod specific,genes
R3716 T5586 T5584 pobj genes,of
R3717 T5587 T5588 dep that,make
R3718 T5588 T5586 relcl make,genes
R3719 T5589 T5590 det the,phenotype
R3720 T5590 T5593 nsubj phenotype,severe
R3721 T5591 T5590 nmod CF,phenotype
R3722 T5592 T5590 amod intestinal,phenotype
R3723 T5593 T5588 ccomp severe,make
R3724 T5594 T5593 advmod less,severe
R3725 T5595 T5568 punct .,focus
R3726 T5710 T5711 amod Wild,type
R3727 T5711 T5712 nmod type,mice
R3728 T5712 T5716 nsubjpass mice,used
R3729 T5713 T5711 cc and,type
R3730 T5714 T5715 npadvmod Cftr,null
R3731 T5715 T5711 conj null,type
R3732 T5717 T5712 prep on,mice
R3733 T5718 T5719 nummod two,backgrounds
R3734 T5719 T5717 pobj backgrounds,on
R3735 T5720 T5719 amod different,backgrounds
R3736 T5721 T5719 amod genetic,backgrounds
R3737 T5722 T5716 auxpass were,used
R3738 T5723 T5716 prep in,used
R3739 T5724 T5725 det this,study
R3740 T5725 T5723 pobj study,in
R3741 T5726 T5716 punct .,used
R3742 T5728 T5729 nummod One,group
R3743 T5729 T5730 nsubj group,was
R3744 T5731 T5730 acomp congenic,was
R3745 T5732 T5731 prep on,congenic
R3746 T5733 T5734 det the,background
R3747 T5734 T5732 pobj background,on
R3748 T5735 T5734 nmod C57Bl,background
R3749 T5736 T5735 punct /,C57Bl
R3750 T5737 T5735 nummod 6,C57Bl
R3751 T5738 T5735 punct (,C57Bl
R3752 T5739 T5735 appos B6,C57Bl
R3753 T5740 T5734 punct ),background
R3754 T5741 T5730 punct ", ",was
R3755 T5742 T5743 mark as,described
R3756 T5743 T5730 advcl described,was
R3757 T5744 T5743 advmod previously,described
R3758 T5745 T5746 punct [,21
R3759 T5746 T5730 parataxis 21,was
R3760 T5747 T5746 punct ],21
R3761 T5748 T5730 punct .,was
R3762 T5750 T5751 det The,group
R3763 T5751 T5753 nsubj group,was
R3764 T5752 T5751 amod other,group
R3765 T5754 T5753 prep on,was
R3766 T5755 T5756 det a,background
R3767 T5756 T5754 pobj background,on
R3768 T5757 T5756 amod mixed,background
R3769 T5758 T5756 prep of,background
R3770 T5759 T5760 advmod about,95
R3771 T5760 T5761 nummod 95,%
R3772 T5761 T5762 compound %,B6
R3773 T5762 T5758 pobj B6,of
R3774 T5763 T5762 cc and,B6
R3775 T5764 T5765 nummod 5,%
R3776 T5765 T5766 nmod %,Sv
R3777 T5766 T5762 conj Sv,B6
R3778 T5767 T5766 nummod 129,Sv
R3779 T5768 T5766 punct /,Sv
R3780 T5769 T5770 punct (,129
R3781 T5770 T5753 parataxis 129,was
R3782 T5771 T5770 punct ),129
R3783 T5772 T5753 punct .,was
R3784 T5774 T5775 det The,mice
R3785 T5775 T5776 nsubj mice,originated
R3786 T5777 T5775 prep on,mice
R3787 T5778 T5779 det the,background
R3788 T5779 T5777 pobj background,on
R3789 T5780 T5779 amod mixed,background
R3790 T5781 T5776 prep as,originated
R3791 T5782 T5781 pobj part,as
R3792 T5783 T5782 prep of,part
R3793 T5784 T5785 det a,study
R3794 T5785 T5783 pobj study,of
R3795 T5786 T5787 advmod recently,published
R3796 T5787 T5785 amod published,study
R3797 T5788 T5789 punct [,20
R3798 T5789 T5785 parataxis 20,study
R3799 T5790 T5789 punct ],20
R3800 T5791 T5792 mark as,follows
R3801 T5792 T5776 advcl follows,originated
R3802 T5793 T5776 punct .,originated
R3803 T5795 T5796 nsubjpass Mice,bred
R3804 T5797 T5795 acl carrying,Mice
R3805 T5798 T5799 det a,mutation
R3806 T5799 T5797 dobj mutation,carrying
R3807 T5800 T5799 amod targeted,mutation
R3808 T5801 T5799 prep of,mutation
R3809 T5802 T5803 det the,gene
R3810 T5803 T5801 pobj gene,of
R3811 T5804 T5803 compound gastrin,gene
R3812 T5805 T5797 prep on,carrying
R3813 T5806 T5807 det a,background
R3814 T5807 T5805 pobj background,on
R3815 T5808 T5807 amod mixed,background
R3816 T5809 T5807 nmod B6,background
R3817 T5810 T5809 punct /,B6
R3818 T5811 T5809 nummod 129,B6
R3819 T5812 T5813 punct [,51
R3820 T5813 T5797 parataxis 51,carrying
R3821 T5814 T5813 punct ],51
R3822 T5815 T5796 auxpass were,bred
R3823 T5816 T5796 prep for,bred
R3824 T5817 T5818 nummod eight,generations
R3825 T5818 T5816 pobj generations,for
R3826 T5819 T5796 prep onto,bred
R3827 T5820 T5821 det the,background
R3828 T5821 T5819 pobj background,onto
R3829 T5822 T5821 compound B6,background
R3830 T5823 T5796 punct .,bred
R3831 T5825 T5826 det The,mice
R3832 T5826 T5833 nsubjpass mice,crossed
R3833 T5827 T5826 nmod gastrin,mice
R3834 T5828 T5827 punct (,gastrin
R3835 T5829 T5827 punct +,gastrin
R3836 T5830 T5827 punct /,gastrin
R3837 T5831 T5827 punct -,gastrin
R3838 T5832 T5827 punct ),gastrin
R3839 T5834 T5833 auxpass were,crossed
R3840 T5835 T5833 advmod then,crossed
R3841 T5836 T5833 prep for,crossed
R3842 T5837 T5838 nummod six,generations
R3843 T5838 T5836 pobj generations,for
R3844 T5839 T5833 prep with,crossed
R3845 T5840 T5841 nmod Cftr,mice
R3846 T5841 T5839 pobj mice,with
R3847 T5842 T5840 punct (,Cftr
R3848 T5843 T5840 punct +,Cftr
R3849 T5844 T5840 punct /,Cftr
R3850 T5845 T5840 punct -,Cftr
R3851 T5846 T5840 punct ),Cftr
R3852 T5847 T5841 amod congenic,mice
R3853 T5848 T5847 prep on,congenic
R3854 T5849 T5850 det the,background
R3855 T5850 T5848 pobj background,on
R3856 T5851 T5850 compound B6,background
R3857 T5852 T5833 punct .,crossed
R3858 T5854 T5855 det A,scan
R3859 T5855 T5857 nsubj scan,showed
R3860 T5856 T5855 compound genome,scan
R3861 T5858 T5857 prep at,showed
R3862 T5859 T5860 det this,point
R3863 T5860 T5858 pobj point,at
R3864 T5861 T5862 mark that,were
R3865 T5862 T5857 ccomp were,showed
R3866 T5863 T5864 det the,mice
R3867 T5864 T5862 nsubj mice,were
R3868 T5865 T5866 advmod about,95
R3869 T5866 T5867 nummod 95,%
R3870 T5867 T5868 compound %,B6
R3871 T5868 T5862 attr B6,were
R3872 T5869 T5868 cc and,B6
R3873 T5870 T5871 nummod 5,%
R3874 T5871 T5868 conj %,B6
R3875 T5872 T5871 nummod 129,%
R3876 T5873 T5874 punct (,see
R3877 T5874 T5857 parataxis see,showed
R3878 T5875 T5874 advmod below,see
R3879 T5876 T5874 punct ),see
R3880 T5877 T5857 punct .,showed
R3881 T5879 T5880 det These,mice
R3882 T5880 T5881 nsubjpass mice,bred
R3883 T5882 T5881 auxpass were,bred
R3884 T5883 T5884 aux to,obtain
R3885 T5884 T5881 advcl obtain,bred
R3886 T5885 T5884 dobj mice,obtain
R3887 T5886 T5887 amod wild,type
R3888 T5887 T5885 amod type,mice
R3889 T5888 T5887 prep for,type
R3890 T5889 T5890 preconj both,alleles
R3891 T5890 T5888 pobj alleles,for
R3892 T5891 T5890 compound gastrin,alleles
R3893 T5892 T5890 cc and,alleles
R3894 T5893 T5894 preconj either,type
R3895 T5894 T5890 conj type,alleles
R3896 T5895 T5894 nmod Cftr,type
R3897 T5896 T5894 amod homozygous,type
R3898 T5897 T5894 amod wild,type
R3899 T5898 T5894 punct [,type
R3900 T5899 T5894 appos Cftr,type
R3901 T5900 T5899 punct (,Cftr
R3902 T5901 T5899 punct +,Cftr
R3903 T5902 T5899 punct /,Cftr
R3904 T5903 T5899 punct +,Cftr
R3905 T5904 T5894 punct ),type
R3906 T5905 T5894 punct ],type
R3907 T5906 T5894 cc or,type
R3908 T5907 T5894 conj Cftr,type
R3909 T5908 T5907 amod homozygous,Cftr
R3910 T5909 T5907 amod null,Cftr
R3911 T5910 T5907 punct [,Cftr
R3912 T5911 T5907 appos Cftr,Cftr
R3913 T5912 T5911 punct (,Cftr
R3914 T5913 T5911 punct -,Cftr
R3915 T5914 T5911 punct /,Cftr
R3916 T5915 T5911 punct -,Cftr
R3917 T5916 T5907 punct ),Cftr
R3918 T5917 T5907 punct ],Cftr
R3919 T5918 T5881 punct .,bred
R3920 T5920 T5921 nsubjpass Mice,genotyped
R3921 T5922 T5921 auxpass were,genotyped
R3922 T5923 T5921 prep at,genotyped
R3923 T5924 T5925 nummod 2,weeks
R3924 T5925 T5923 pobj weeks,at
R3925 T5926 T5925 prep of,weeks
R3926 T5927 T5926 pobj age,of
R3927 T5928 T5921 prep by,genotyped
R3928 T5929 T5928 pobj PCR,by
R3929 T5930 T5931 mark as,described
R3930 T5931 T5921 advcl described,genotyped
R3931 T5932 T5931 advmod previously,described
R3932 T5933 T5934 punct [,21
R3933 T5934 T5921 parataxis 21,genotyped
R3934 T5935 T5934 punct ],21
R3935 T5936 T5921 punct .,genotyped
R3936 T5938 T5939 mark Unless,stated
R3937 T5939 T5941 advcl stated,maintained
R3938 T5940 T5939 advmod otherwise,stated
R3939 T5942 T5941 punct ", ",maintained
R3940 T5943 T5941 nsubjpass mice,maintained
R3941 T5944 T5941 auxpass were,maintained
R3942 T5945 T5941 prep on,maintained
R3943 T5946 T5947 det a,diet
R3944 T5947 T5945 pobj diet,on
R3945 T5948 T5947 amod complete,diet
R3946 T5949 T5947 amod elemental,diet
R3947 T5950 T5947 compound liquid,diet
R3948 T5951 T5952 punct (,Deerfield
R3949 T5952 T5941 parataxis Deerfield,maintained
R3950 T5953 T5952 dep Peptamen,Deerfield
R3951 T5954 T5952 punct ;,Deerfield
R3952 T5955 T5952 compound Nestle,Deerfield
R3953 T5956 T5952 punct ", ",Deerfield
R3954 T5957 T5952 npadvmod IL,Deerfield
R3955 T5958 T5952 punct ),Deerfield
R3956 T5959 T5960 aux to,prevent
R3957 T5960 T5941 advcl prevent,maintained
R3958 T5961 T5962 amod intestinal,obstruction
R3959 T5962 T5960 dobj obstruction,prevent
R3960 T5963 T5964 dep that,occurs
R3961 T5964 T5962 relcl occurs,obstruction
R3962 T5965 T5964 prep in,occurs
R3963 T5966 T5967 compound CF,mice
R3964 T5967 T5965 pobj mice,in
R3965 T5968 T5969 punct [,52
R3966 T5969 T5941 parataxis 52,maintained
R3967 T5970 T5969 punct ],52
R3968 T5971 T5941 punct .,maintained
R3969 T5973 T5974 amod Wild,type
R3970 T5974 T5975 compound type,littermates
R3971 T5975 T5976 nsubjpass littermates,maintained
R3972 T5977 T5976 auxpass were,maintained
R3973 T5978 T5976 prep on,maintained
R3974 T5979 T5980 det the,diet
R3975 T5980 T5978 pobj diet,on
R3976 T5981 T5980 amod same,diet
R3977 T5982 T5976 punct .,maintained
R3978 T5984 T5985 prep In,transferred
R3979 T5986 T5987 det some,experiments
R3980 T5987 T5984 pobj experiments,In
R3981 T5988 T5985 punct ", ",transferred
R3982 T5989 T5990 nummod 8,week
R3983 T5990 T5991 npadvmod week,old
R3984 T5991 T5992 amod old,mice
R3985 T5992 T5985 nsubjpass mice,transferred
R3986 T5993 T5985 auxpass were,transferred
R3987 T5994 T5985 prep onto,transferred
R3988 T5995 T5996 amod solid,chow
R3989 T5996 T5994 pobj chow,onto
R3990 T5997 T5996 compound mouse,chow
R3991 T5998 T5999 advmod instead,of
R3992 T5999 T5996 cc of,chow
R3993 T6000 T5996 conj Peptamen,chow
R3994 T6001 T5985 punct ", ",transferred
R3995 T6002 T5985 cc and,transferred
R3996 T6003 T6004 nsubjpass survival,recorded
R3997 T6004 T5985 conj recorded,transferred
R3998 T6005 T6004 auxpass was,recorded
R3999 T6006 T6004 punct .,recorded
R4000 T6008 T6009 nsubjpass Mice,sacrificed
R4001 T6010 T6008 prep with,Mice
R4002 T6011 T6012 amod apparent,distress
R4003 T6012 T6010 pobj distress,with
R4004 T6013 T6009 auxpass were,sacrificed
R4005 T6014 T6009 cc and,sacrificed
R4006 T6015 T6016 nsubjpass survival,recorded
R4007 T6016 T6009 conj recorded,sacrificed
R4008 T6017 T6015 prep on,survival
R4009 T6018 T6017 pobj chow,on
R4010 T6019 T6016 auxpass was,recorded
R4011 T6020 T6016 prep as,recorded
R4012 T6021 T6022 det the,day
R4013 T6022 T6020 pobj day,as
R4014 T6023 T6022 amod following,day
R4015 T6024 T6016 punct .,recorded
R4016 T6026 T6027 amod Male,mice
R4017 T6027 T6030 nsubjpass mice,used
R4018 T6028 T6026 cc and,Male
R4019 T6029 T6026 conj female,Male
R4020 T6031 T6030 auxpass were,used
R4021 T6032 T6030 prep at,used
R4022 T6033 T6034 quantmod 6,16
R4023 T6034 T6036 nummod 16,weeks
R4024 T6035 T6034 punct –,16
R4025 T6036 T6032 pobj weeks,at
R4026 T6037 T6036 prep of,weeks
R4027 T6038 T6037 pobj age,of
R4028 T6039 T6030 punct .,used
R4029 T6041 T6042 nsubjpass Mice,kept
R4030 T6043 T6042 auxpass were,kept
R4031 T6044 T6042 prep in,kept
R4032 T6045 T6046 det a,facility
R4033 T6046 T6044 pobj facility,in
R4034 T6047 T6046 amod specific,facility
R4035 T6048 T6046 nmod pathogen,facility
R4036 T6049 T6048 punct -,pathogen
R4037 T6050 T6048 amod free,pathogen
R4038 T6051 T6042 prep in,kept
R4039 T6052 T6053 compound barrier,top
R4040 T6053 T6055 compound top,cages
R4041 T6054 T6053 punct -,top
R4042 T6055 T6051 pobj cages,in
R4043 T6056 T6042 punct .,kept
R4044 T6058 T6059 det All,procedures
R4045 T6059 T6060 nsubjpass procedures,approved
R4046 T6061 T6060 auxpass were,approved
R4047 T6062 T6060 agent by,approved
R4048 T6063 T6064 det the,University
R4049 T6064 T6065 nmod University,Center
R4050 T6065 T6069 compound Center,IACUC
R4051 T6066 T6064 prep of,University
R4052 T6067 T6066 pobj Kansas,of
R4053 T6068 T6065 compound Medical,Center
R4054 T6069 T6062 pobj IACUC,by
R4055 T6070 T6060 punct .,approved
R4056 T6097 T6098 amod Genetic,background
R4057 T6098 T6099 compound background,determination
R4058 T6101 T6102 det The,Service
R4059 T6102 T6105 nsubjpass Service,used
R4060 T6103 T6102 compound Genome,Service
R4061 T6104 T6102 compound Scanning,Service
R4062 T6106 T6102 prep of,Service
R4063 T6107 T6108 det The,Laboratory
R4064 T6108 T6106 pobj Laboratory,of
R4065 T6109 T6108 compound Jackson,Laboratory
R4066 T6110 T6111 punct (,Harbor
R4067 T6111 T6108 parataxis Harbor,Laboratory
R4068 T6112 T6111 compound Bar,Harbor
R4069 T6113 T6111 punct ", ",Harbor
R4070 T6114 T6111 npadvmod ME,Harbor
R4071 T6115 T6111 punct ),Harbor
R4072 T6116 T6105 auxpass was,used
R4073 T6117 T6118 aux to,determine
R4074 T6118 T6105 advcl determine,used
R4075 T6119 T6120 det the,contributions
R4076 T6120 T6118 dobj contributions,determine
R4077 T6121 T6120 prep of,contributions
R4078 T6122 T6123 nmod C57Bl,strains
R4079 T6123 T6121 pobj strains,of
R4080 T6124 T6122 punct /,C57Bl
R4081 T6125 T6122 nummod 6,C57Bl
R4082 T6126 T6122 cc and,C57Bl
R4083 T6127 T6128 nummod 129,Sv
R4084 T6128 T6122 conj Sv,C57Bl
R4085 T6129 T6128 punct /,Sv
R4086 T6130 T6118 prep in,determine
R4087 T6131 T6132 det the,mice
R4088 T6132 T6130 pobj mice,in
R4089 T6133 T6132 amod interbred,mice
R4090 T6134 T6105 punct .,used
R4091 T6136 T6137 nsubjpass Pieces,sent
R4092 T6138 T6136 prep of,Pieces
R4093 T6139 T6140 compound mouse,tail
R4094 T6140 T6138 pobj tail,of
R4095 T6141 T6137 auxpass were,sent
R4096 T6142 T6137 prep to,sent
R4097 T6143 T6144 det The,Laboratory
R4098 T6144 T6142 pobj Laboratory,to
R4099 T6145 T6144 compound Jackson,Laboratory
R4100 T6146 T6137 prep for,sent
R4101 T6147 T6148 amod simple,polymorphism
R4102 T6148 T6151 nmod polymorphism,analysis
R4103 T6149 T6148 nmod sequence,polymorphism
R4104 T6150 T6148 nmod length,polymorphism
R4105 T6151 T6146 pobj analysis,for
R4106 T6152 T6148 punct (,polymorphism
R4107 T6153 T6148 appos SSLP,polymorphism
R4108 T6154 T6151 punct ),analysis
R4109 T6155 T6151 compound PCR,analysis
R4110 T6156 T6137 prep with,sent
R4111 T6157 T6158 det the,primers
R4112 T6158 T6156 pobj primers,with
R4113 T6159 T6158 compound DMit,primers
R4114 T6160 T6158 amod specific,primers
R4115 T6161 T6160 prep for,specific
R4116 T6162 T6163 nmod B6,strain
R4117 T6163 T6166 compound strain,alleles
R4118 T6164 T6162 cc and,B6
R4119 T6165 T6162 conj 129,B6
R4120 T6166 T6161 pobj alleles,for
R4121 T6167 T6137 punct .,sent
R4122 T6169 T6170 det The,panel
R4123 T6170 T6172 nsubj panel,consists
R4124 T6171 T6170 compound SSLP,panel
R4125 T6173 T6172 prep of,consists
R4126 T6174 T6175 nummod 108,markers
R4127 T6175 T6173 pobj markers,of
R4128 T6176 T6175 amod mapped,markers
R4129 T6177 T6175 acl designed,markers
R4130 T6178 T6179 aux to,distinguish
R4131 T6179 T6177 advcl distinguish,designed
R4132 T6180 T6179 prep between,distinguish
R4133 T6181 T6182 nmod B6,strains
R4134 T6182 T6180 pobj strains,between
R4135 T6183 T6181 cc and,B6
R4136 T6184 T6181 conj 129,B6
R4137 T6185 T6172 punct .,consists
R4138 T6187 T6188 det The,markers
R4139 T6188 T6189 nsubjpass markers,spaced
R4140 T6190 T6189 auxpass are,spaced
R4141 T6191 T6192 quantmod 12,13
R4142 T6192 T6194 nummod 13,cM
R4143 T6193 T6192 punct –,13
R4144 T6194 T6195 npadvmod cM,apart
R4145 T6195 T6189 advmod apart,spaced
R4146 T6196 T6189 cc and,spaced
R4147 T6197 T6189 conj span,spaced
R4148 T6198 T6199 det the,autosomes
R4149 T6199 T6197 dobj autosomes,span
R4150 T6200 T6199 nummod nineteen,autosomes
R4151 T6201 T6189 punct .,spaced
R4156 T6254 T6253 prep of,Measurement
R4157 T6255 T6256 compound gene,expression
R4158 T6256 T6254 pobj expression,of
R4159 T6258 T6259 amod Total,RNA
R4160 T6259 T6260 nsubjpass RNA,extracted
R4161 T6261 T6260 auxpass was,extracted
R4162 T6262 T6260 prep from,extracted
R4163 T6263 T6264 det the,intestine
R4164 T6264 T6262 pobj intestine,from
R4165 T6265 T6264 amod entire,intestine
R4166 T6266 T6264 amod small,intestine
R4167 T6267 T6268 mark as,described
R4168 T6268 T6260 advcl described,extracted
R4169 T6269 T6268 advmod previously,described
R4170 T6270 T6271 punct [,21
R4171 T6271 T6260 parataxis 21,extracted
R4172 T6272 T6271 punct ],21
R4173 T6273 T6260 punct .,extracted
R4174 T6275 T6276 amod Quantitative,PCR
R4175 T6276 T6283 nsubjpass PCR,used
R4176 T6277 T6276 punct ", ",PCR
R4177 T6278 T6279 amod real,time
R4178 T6279 T6276 compound time,PCR
R4179 T6280 T6279 punct -,time
R4180 T6281 T6276 compound RT,PCR
R4181 T6282 T6276 punct -,PCR
R4182 T6284 T6283 auxpass was,used
R4183 T6285 T6286 aux to,measure
R4184 T6286 T6283 advcl measure,used
R4185 T6287 T6286 dobj expression,measure
R4186 T6288 T6287 prep of,expression
R4187 T6289 T6290 amod specific,genes
R4188 T6290 T6288 pobj genes,of
R4189 T6291 T6286 advcl using,measure
R4190 T6292 T6293 det the,primers
R4191 T6293 T6291 dobj primers,using
R4192 T6294 T6295 advmod previously,described
R4193 T6295 T6293 amod described,primers
R4194 T6296 T6297 punct [,21
R4195 T6297 T6283 parataxis 21,used
R4196 T6298 T6297 punct ],21
R4197 T6299 T6283 punct .,used
R4198 T6301 T6302 nsubjpass Values,normalized
R4199 T6303 T6302 auxpass were,normalized
R4200 T6304 T6302 prep to,normalized
R4201 T6305 T6306 compound GAPDH,mRNA
R4202 T6306 T6304 pobj mRNA,to
R4203 T6307 T6302 cc and,normalized
R4204 T6308 T6309 nsubjpass expression,altered
R4205 T6309 T6302 conj altered,normalized
R4206 T6310 T6308 prep of,expression
R4207 T6311 T6312 det this,gene
R4208 T6312 T6310 pobj gene,of
R4209 T6313 T6312 compound housekeeping,gene
R4210 T6314 T6309 auxpass is,altered
R4211 T6315 T6309 neg not,altered
R4212 T6316 T6309 prep in,altered
R4213 T6317 T6318 det the,intestine
R4214 T6318 T6316 pobj intestine,in
R4215 T6319 T6320 nmod CF,mouse
R4216 T6320 T6318 nmod mouse,intestine
R4217 T6321 T6318 amod small,intestine
R4218 T6322 T6323 punct [,21
R4219 T6323 T6309 parataxis 21,altered
R4220 T6324 T6323 punct ],21
R4221 T6325 T6309 punct .,altered
R4222 T6327 T6328 nsubjpass Expression,measured
R4223 T6329 T6327 prep of,Expression
R4224 T6330 T6331 det the,mucin
R4225 T6331 T6329 pobj mucin,of
R4226 T6332 T6331 amod major,mucin
R4227 T6333 T6331 amod intestinal,mucin
R4228 T6334 T6331 punct ", ",mucin
R4229 T6335 T6331 appos Muc2,mucin
R4230 T6336 T6328 punct ", ",measured
R4231 T6337 T6328 auxpass was,measured
R4232 T6338 T6328 advmod also,measured
R4233 T6339 T6328 advcl using,measured
R4234 T6340 T6341 det the,primers
R4235 T6341 T6339 dobj primers,using
R4236 T6342 T6341 amod forward,primers
R4237 T6343 T6344 punct (,TC
R4238 T6344 T6342 parataxis TC,forward
R4239 T6345 T6344 nummod 5,TC
R4240 T6346 T6345 punct ',5
R4241 T6347 T6344 punct -,TC
R4242 T6348 T6344 compound GAC,TC
R4243 T6349 T6344 compound TTC,TC
R4244 T6350 T6344 compound GAT,TC
R4245 T6351 T6344 compound GGA,TC
R4246 T6352 T6344 compound CAC,TC
R4247 T6353 T6344 compound TGC,TC
R4248 T6354 T6344 punct -,TC
R4249 T6355 T6344 nummod 3,TC
R4250 T6356 T6344 punct ',TC
R4251 T6357 T6344 punct ),TC
R4252 T6358 T6342 cc and,forward
R4253 T6359 T6342 conj reverse,forward
R4254 T6360 T6361 punct (,AC
R4255 T6361 T6359 parataxis AC,reverse
R4256 T6362 T6361 nummod 5,AC
R4257 T6363 T6362 punct ',5
R4258 T6364 T6361 punct -,AC
R4259 T6365 T6361 compound CAC,AC
R4260 T6366 T6361 compound GGT,AC
R4261 T6367 T6361 compound GTT,AC
R4262 T6368 T6361 compound TAT,AC
R4263 T6369 T6361 compound CTA,AC
R4264 T6370 T6361 compound CCA,AC
R4265 T6371 T6361 punct -,AC
R4266 T6372 T6361 nummod 3,AC
R4267 T6373 T6361 punct ',AC
R4268 T6374 T6361 punct ),AC
R4269 T6375 T6328 punct .,measured
R4270 T6392 T6393 det The,intestine
R4271 T6393 T6395 nsubjpass intestine,flushed
R4272 T6394 T6393 amod small,intestine
R4273 T6396 T6395 auxpass was,flushed
R4274 T6397 T6395 prep with,flushed
R4275 T6398 T6399 nmod phosphate,saline
R4276 T6399 T6397 pobj saline,with
R4277 T6400 T6398 amod buffered,phosphate
R4278 T6401 T6395 cc and,flushed
R4279 T6402 T6403 dep immersion,fixed
R4280 T6403 T6395 conj fixed,flushed
R4281 T6404 T6403 advmod overnight,fixed
R4282 T6405 T6403 prep in,fixed
R4283 T6406 T6407 nummod 4,%
R4284 T6407 T6408 compound %,paraformaldehyde
R4285 T6408 T6405 pobj paraformaldehyde,in
R4286 T6409 T6395 punct .,flushed
R4287 T6411 T6412 det The,tissues
R4288 T6412 T6413 nsubjpass tissues,prepared
R4289 T6414 T6413 auxpass were,prepared
R4290 T6415 T6413 advmod then,prepared
R4291 T6416 T6413 prep for,prepared
R4292 T6417 T6418 compound paraffin,embedding
R4293 T6418 T6416 pobj embedding,for
R4294 T6419 T6418 cc and,embedding
R4295 T6420 T6418 conj sectioning,embedding
R4296 T6421 T6413 agent by,prepared
R4297 T6422 T6423 det a,service
R4298 T6423 T6421 pobj service,by
R4299 T6424 T6423 amod commercial,service
R4300 T6425 T6426 punct (,HSRL
R4301 T6426 T6423 parataxis HSRL,service
R4302 T6427 T6426 punct ", ",HSRL
R4303 T6428 T6426 npadvmod Woodstock,HSRL
R4304 T6429 T6426 punct ", ",HSRL
R4305 T6430 T6426 npadvmod VA,HSRL
R4306 T6431 T6426 punct ),HSRL
R4307 T6432 T6413 punct .,prepared
R4308 T6434 T6435 nsubjpass Sections,stained
R4309 T6436 T6437 punct (,μm
R4310 T6437 T6434 parataxis μm,Sections
R4311 T6438 T6437 nummod 5,μm
R4312 T6439 T6437 punct ),μm
R4313 T6440 T6435 auxpass were,stained
R4314 T6441 T6435 prep with,stained
R4315 T6442 T6443 amod periodic,acid
R4316 T6443 T6444 compound acid,Schiff
R4317 T6444 T6445 poss Schiff,PAS
R4318 T6445 T6441 pobj PAS,with
R4319 T6446 T6444 case 's,Schiff
R4320 T6447 T6445 punct (,PAS
R4321 T6448 T6435 punct ),stained
R4322 T6449 T6435 prep for,stained
R4323 T6450 T6451 amod neutral,mucins
R4324 T6451 T6449 pobj mucins,for
R4325 T6452 T6435 punct .,stained
R4326 T6474 T6475 nmod Gene,expression
R4327 T6475 T6476 nmod expression,data
R4328 T6476 T6480 nsubjpass data,compared
R4329 T6477 T6475 cc and,expression
R4330 T6478 T6479 compound body,weight
R4331 T6479 T6475 conj weight,expression
R4332 T6481 T6480 auxpass were,compared
R4333 T6482 T6480 prep by,compared
R4334 T6483 T6482 pobj ANOVA,by
R4335 T6484 T6480 prep with,compared
R4336 T6485 T6486 det a,analysis
R4337 T6486 T6484 pobj analysis,with
R4338 T6487 T6486 amod post-hoc,analysis
R4339 T6488 T6486 poss Tukey,analysis
R4340 T6489 T6488 case 's,Tukey
R4341 T6490 T6491 punct (,software
R4342 T6491 T6486 parataxis software,analysis
R4343 T6492 T6491 compound Systat,software
R4344 T6493 T6491 punct ", ",software
R4345 T6494 T6491 npadvmod Chicago,software
R4346 T6495 T6491 punct ", ",software
R4347 T6496 T6491 npadvmod IL,software
R4348 T6497 T6491 punct ),software
R4349 T6498 T6480 punct .,compared
R4350 T6500 T6501 compound Survival,data
R4351 T6501 T6502 nsubjpass data,analyzed
R4352 T6503 T6502 auxpass were,analyzed
R4353 T6504 T6502 prep by,analyzed
R4354 T6505 T6506 det a,test
R4355 T6506 T6504 pobj test,by
R4356 T6507 T6508 compound log,rank
R4357 T6508 T6506 compound rank,test
R4358 T6509 T6508 punct -,rank
R4359 T6510 T6502 prep for,analyzed
R4360 T6511 T6512 compound P,values
R4361 T6512 T6510 pobj values,for
R4362 T6513 T6514 punct (,software
R4363 T6514 T6502 parataxis software,analyzed
R4364 T6515 T6514 compound PEPI,software
R4365 T6516 T6514 punct ", ",software
R4366 T6517 T6514 punct ),software
R4367 T6518 T6502 punct .,analyzed
R4368 T6520 T6521 det The,distributions
R4369 T6521 T6522 nsubjpass distributions,compared
R4370 T6523 T6521 prep of,distributions
R4371 T6524 T6523 pobj genotypes,of
R4372 T6525 T6524 prep of,genotypes
R4373 T6526 T6525 pobj pups,of
R4374 T6527 T6526 acl surviving,pups
R4375 T6528 T6527 prep to,surviving
R4376 T6529 T6528 pobj weaning,to
R4377 T6530 T6527 prep from,surviving
R4378 T6531 T6532 amod breeding,mice
R4379 T6532 T6530 pobj mice,from
R4380 T6533 T6532 nmod Cftr,mice
R4381 T6534 T6533 punct (,Cftr
R4382 T6535 T6533 punct +,Cftr
R4383 T6536 T6533 punct /,Cftr
R4384 T6537 T6533 punct -,Cftr
R4385 T6538 T6533 punct ),Cftr
R4386 T6539 T6522 auxpass were,compared
R4387 T6540 T6522 prep to,compared
R4388 T6541 T6540 pobj that,to
R4389 T6542 T6541 acl expected,that
R4390 T6543 T6542 prep by,expected
R4391 T6544 T6545 amod Mendelian,genetics
R4392 T6545 T6543 pobj genetics,by
R4393 T6546 T6522 advcl using,compared
R4394 T6547 T6548 compound Chi,square
R4395 T6548 T6550 compound square,analysis
R4396 T6549 T6548 punct -,square
R4397 T6550 T6546 dobj analysis,using
R4398 T6551 T6522 punct .,compared
R4399 T6553 T6554 prep For,considered
R4400 T6555 T6556 det all,tests
R4401 T6556 T6553 pobj tests,For
R4402 T6557 T6556 amod statistical,tests
R4403 T6558 T6554 punct ", ",considered
R4404 T6559 T6554 nsubjpass P,considered
R4405 T6560 T6561 punct <,0.05
R4406 T6561 T6559 amod 0.05,P
R4407 T6562 T6554 auxpass was,considered
R4408 T6563 T6554 oprd significant,considered
R4409 T6564 T6554 punct .,considered
R4410 T6585 T6584 prep of,Effect
R4411 T6586 T6587 amod genetic,background
R4412 T6587 T6585 pobj background,of
R4413 T6588 T6584 prep on,Effect
R4414 T6589 T6590 compound body,weights
R4415 T6590 T6588 pobj weights,on
R4416 T6591 T6590 prep of,weights
R4417 T6592 T6593 compound CF,mice
R4418 T6593 T6591 pobj mice,of
R4419 T6594 T6584 punct .,Effect
R4420 T6596 T6597 punct (,A
R4421 T6597 T6598 parataxis A,Female
R4422 T6598 T6600 amod Female,mice
R4423 T6599 T6597 punct ),A
R4424 T6600 T6606 nsubjpass mice,weighed
R4425 T6601 T6598 cc and,Female
R4426 T6602 T6603 punct (,B
R4427 T6603 T6604 parataxis B,male
R4428 T6604 T6598 conj male,Female
R4429 T6605 T6603 punct ),B
R4430 T6607 T6606 auxpass were,weighed
R4431 T6608 T6606 prep at,weighed
R4432 T6609 T6610 nummod 4,weeks
R4433 T6610 T6608 pobj weeks,at
R4434 T6611 T6609 cc and,4
R4435 T6612 T6609 conj 8,4
R4436 T6613 T6610 prep of,weeks
R4437 T6614 T6613 pobj age,of
R4438 T6615 T6606 punct .,weighed
R4439 T6617 T6618 nsubj Data,are
R4440 T6619 T6620 nmod means,SEM
R4441 T6620 T6618 attr SEM,are
R4442 T6621 T6620 punct ±,SEM
R4443 T6622 T6618 punct .,are
R4444 T6624 T6625 punct (,*
R4445 T6625 T6626 meta *,0.001
R4446 T6627 T6625 punct ),*
R4447 T6628 T6626 nsubj P,0.001
R4448 T6629 T6626 punct <,0.001
R4449 T6630 T6626 cc vs,0.001
R4450 T6631 T6632 amod other,groups
R4451 T6632 T6626 conj groups,0.001
R4452 T6633 T6632 nummod three,groups
R4453 T6634 T6626 prep by,0.001
R4454 T6635 T6634 pobj ANOVA,by
R4455 T6636 T6626 prep with,0.001
R4456 T6637 T6638 det a,test
R4457 T6638 T6636 pobj test,with
R4458 T6639 T6638 amod post-hoc,test
R4459 T6640 T6638 poss Tukey,test
R4460 T6641 T6640 case 's,Tukey
R4461 T6642 T6626 punct .,0.001
R4462 T6644 T6645 expl There,were
R4463 T6646 T6647 det no,differences
R4464 T6647 T6645 attr differences,were
R4465 T6648 T6647 amod significant,differences
R4466 T6649 T6647 prep for,differences
R4467 T6650 T6649 pobj any,for
R4468 T6651 T6650 prep of,any
R4469 T6652 T6653 det the,comparisons
R4470 T6653 T6651 pobj comparisons,of
R4471 T6654 T6653 amod other,comparisons
R4472 T6655 T6645 punct .,were
R4473 T6657 T6658 nsubjpass Data,obtained
R4474 T6659 T6658 auxpass were,obtained
R4475 T6660 T6658 prep from,obtained
R4476 T6661 T6660 punct : ,from
R4477 T6662 T6663 nummod 65,type
R4478 T6663 T6660 pobj type,from
R4479 T6664 T6663 amod wild,type
R4480 T6665 T6663 cc and,type
R4481 T6666 T6667 nummod 26,B6
R4482 T6667 T6669 compound B6,females
R4483 T6668 T6667 compound CF,B6
R4484 T6669 T6663 conj females,type
R4485 T6670 T6663 punct ", ",type
R4486 T6671 T6672 nummod 36,type
R4487 T6672 T6663 conj type,type
R4488 T6673 T6672 amod wild,type
R4489 T6674 T6672 cc and,type
R4490 T6675 T6676 nummod 8,background
R4491 T6676 T6679 compound background,females
R4492 T6677 T6676 nmod CF,background
R4493 T6678 T6676 amod mixed,background
R4494 T6679 T6672 conj females,type
R4495 T6680 T6672 punct ", ",type
R4496 T6681 T6682 nummod 68,type
R4497 T6682 T6672 conj type,type
R4498 T6683 T6682 amod wild,type
R4499 T6684 T6682 cc and,type
R4500 T6685 T6686 nummod 30,B6
R4501 T6686 T6688 compound B6,males
R4502 T6687 T6686 compound CF,B6
R4503 T6688 T6682 conj males,type
R4504 T6689 T6682 punct ", ",type
R4505 T6690 T6682 cc and,type
R4506 T6691 T6692 nummod 37,type
R4507 T6692 T6682 conj type,type
R4508 T6693 T6692 amod wild,type
R4509 T6694 T6692 cc and,type
R4510 T6695 T6696 nummod 6,background
R4511 T6696 T6699 compound background,males
R4512 T6697 T6696 nmod CF,background
R4513 T6698 T6696 amod mixed,background
R4514 T6699 T6692 conj males,type
R4515 T6700 T6658 punct .,obtained
R4516 T6752 T6751 prep of,Effect
R4517 T6753 T6754 amod genetic,background
R4518 T6754 T6752 pobj background,of
R4519 T6755 T6751 prep on,Effect
R4520 T6756 T6757 amod inflammatory,expression
R4521 T6757 T6755 pobj expression,on
R4522 T6758 T6757 compound gene,expression
R4523 T6759 T6751 prep in,Effect
R4524 T6760 T6761 nmod CF,mouse
R4525 T6761 T6762 nmod mouse,intestine
R4526 T6762 T6759 pobj intestine,in
R4527 T6763 T6762 amod small,intestine
R4528 T6764 T6751 punct .,Effect
R4529 T6766 T6767 compound RNA,levels
R4530 T6767 T6769 nsubjpass levels,determined
R4531 T6768 T6767 compound expression,levels
R4532 T6770 T6769 auxpass were,determined
R4533 T6771 T6769 prep by,determined
R4534 T6772 T6773 amod quantitative,PCR
R4535 T6773 T6771 pobj PCR,by
R4536 T6774 T6775 amod real,time
R4537 T6775 T6773 compound time,PCR
R4538 T6776 T6775 punct -,time
R4539 T6777 T6773 compound RT,PCR
R4540 T6778 T6773 punct -,PCR
R4541 T6779 T6769 advcl using,determined
R4542 T6780 T6781 npadvmod gene,specific
R4543 T6781 T6783 amod specific,primers
R4544 T6782 T6781 punct -,specific
R4545 T6783 T6779 dobj primers,using
R4546 T6784 T6769 punct .,determined
R4547 T6786 T6787 nsubjpass Data,expressed
R4548 T6788 T6787 auxpass are,expressed
R4549 T6789 T6787 advcl relative,expressed
R4550 T6790 T6789 prep to,relative
R4551 T6791 T6792 compound GAPDH,mRNA
R4552 T6792 T6790 pobj mRNA,to
R4553 T6793 T6792 punct ", ",mRNA
R4554 T6794 T6795 dep which,vary
R4555 T6795 T6792 relcl vary,mRNA
R4556 T6796 T6795 aux does,vary
R4557 T6797 T6795 neg not,vary
R4558 T6798 T6795 prep between,vary
R4559 T6799 T6800 amod wild,type
R4560 T6800 T6801 nmod type,mice
R4561 T6801 T6798 pobj mice,between
R4562 T6802 T6800 cc and,type
R4563 T6803 T6800 conj CF,type
R4564 T6804 T6787 punct .,expressed
R4565 T6806 T6807 nsubj Data,are
R4566 T6808 T6809 nmod means,SEM
R4567 T6809 T6807 attr SEM,are
R4568 T6810 T6809 punct ±,SEM
R4569 T6811 T6807 punct .,are
R4570 T6813 T6814 punct (,*
R4571 T6814 T6815 meta *,0.005
R4572 T6815 T6828 dep 0.005,CF
R4573 T6816 T6814 punct ),*
R4574 T6817 T6815 dep CF,0.005
R4575 T6818 T6817 cc vs,CF
R4576 T6819 T6820 amod wild,type
R4577 T6820 T6817 conj type,CF
R4578 T6821 T6817 prep on,CF
R4579 T6822 T6823 det the,background
R4580 T6823 T6821 pobj background,on
R4581 T6824 T6823 compound B6,background
R4582 T6825 T6815 punct ", ",0.005
R4583 T6826 T6815 nsubj P,0.005
R4584 T6827 T6815 punct <,0.005
R4585 T6829 T6828 punct ;,CF
R4586 T6830 T6831 punct (,+
R4587 T6831 T6828 meta +,CF
R4588 T6832 T6831 punct ),+
R4589 T6833 T6828 prep on,CF
R4590 T6834 T6835 det the,background
R4591 T6835 T6833 pobj background,on
R4592 T6836 T6835 amod mixed,background
R4593 T6837 T6828 cc vs,CF
R4594 T6838 T6828 conj CF,CF
R4595 T6839 T6838 prep on,CF
R4596 T6840 T6841 det the,background
R4597 T6841 T6839 pobj background,on
R4598 T6842 T6841 compound B6,background
R4599 T6843 T6828 punct ", ",CF
R4600 T6844 T6845 nsubj P,0.05
R4601 T6845 T6828 dep 0.05,CF
R4602 T6846 T6845 punct <,0.05
R4603 T6847 T6845 prep by,0.05
R4604 T6848 T6847 pobj ANOVA,by
R4605 T6849 T6845 prep with,0.05
R4606 T6850 T6851 det a,test
R4607 T6851 T6849 pobj test,with
R4608 T6852 T6851 amod post-hoc,test
R4609 T6853 T6851 poss Tukey,test
R4610 T6854 T6853 case 's,Tukey
R4611 T6855 T6828 punct .,CF
R4612 T6857 T6858 expl There,were
R4613 T6859 T6860 det no,differences
R4614 T6860 T6858 attr differences,were
R4615 T6861 T6860 amod significant,differences
R4616 T6862 T6858 prep for,were
R4617 T6863 T6862 pobj any,for
R4618 T6864 T6863 prep of,any
R4619 T6865 T6866 det the,genes
R4620 T6866 T6864 pobj genes,of
R4621 T6867 T6866 nummod 6,genes
R4622 T6868 T6866 acl comparing,genes
R4623 T6869 T6868 punct : ,comparing
R4624 T6870 T6871 amod wild,type
R4625 T6871 T6872 compound type,mice
R4626 T6872 T6868 dobj mice,comparing
R4627 T6873 T6872 compound B6,mice
R4628 T6874 T6872 cc vs,mice
R4629 T6875 T6876 amod wild,type
R4630 T6876 T6877 nmod type,background
R4631 T6877 T6872 conj background,mice
R4632 T6878 T6877 amod mixed,background
R4633 T6879 T6872 punct ;,mice
R4634 T6880 T6872 cc or,mice
R4635 T6881 T6882 compound CF,mice
R4636 T6882 T6872 conj mice,mice
R4637 T6883 T6882 prep on,mice
R4638 T6884 T6885 det the,background
R4639 T6885 T6883 pobj background,on
R4640 T6886 T6885 amod mixed,background
R4641 T6887 T6882 cc vs,mice
R4642 T6888 T6889 amod wild,type
R4643 T6889 T6882 conj type,mice
R4644 T6890 T6889 prep on,type
R4645 T6891 T6892 det either,background
R4646 T6892 T6890 pobj background,on
R4647 T6893 T6858 punct .,were
R4648 T6895 T6896 expl There,were
R4649 T6897 T6898 quantmod 8,11
R4650 T6898 T6900 nummod 11,samples
R4651 T6899 T6898 punct –,11
R4652 T6900 T6896 attr samples,were
R4653 T6901 T6900 acl analyzed,samples
R4654 T6902 T6901 prep per,analyzed
R4655 T6903 T6902 pobj group,per
R4656 T6904 T6901 prep for,analyzed
R4657 T6905 T6906 det each,gene
R4658 T6906 T6904 pobj gene,for
R4659 T6907 T6896 punct .,were
R4660 T6955 T6956 amod Histological,appearance
R4661 T6957 T6956 prep of,appearance
R4662 T6958 T6959 det the,intestine
R4663 T6959 T6957 pobj intestine,of
R4664 T6960 T6959 amod small,intestine
R4665 T6961 T6959 prep of,intestine
R4666 T6962 T6963 amod wild,type
R4667 T6963 T6964 nmod type,mice
R4668 T6964 T6961 pobj mice,of
R4669 T6965 T6963 cc and,type
R4670 T6966 T6963 conj CF,type
R4671 T6967 T6964 prep on,mice
R4672 T6968 T6969 det the,backgrounds
R4673 T6969 T6967 pobj backgrounds,on
R4674 T6970 T6969 amod different,backgrounds
R4675 T6971 T6969 amod genetic,backgrounds
R4676 T6972 T6956 punct .,appearance
R4677 T6974 T6975 nsubjpass Tissue,embedded
R4678 T6976 T6975 auxpass was,embedded
R4679 T6977 T6975 dep paraffin,embedded
R4680 T6978 T6975 cc and,embedded
R4681 T6979 T6975 conj stained,embedded
R4682 T6980 T6979 prep with,stained
R4683 T6981 T6980 pobj PAS,with
R4684 T6982 T6979 prep for,stained
R4685 T6983 T6984 amod neutral,mucins
R4686 T6984 T6982 pobj mucins,for
R4687 T6985 T6975 punct .,embedded
R4688 T6987 T6988 det The,sections
R4689 T6988 T6989 nsubj sections,are
R4690 T6990 T6989 prep from,are
R4691 T6991 T6992 det the,portion
R4692 T6992 T6990 pobj portion,from
R4693 T6993 T6992 amod middle,portion
R4694 T6994 T6992 prep of,portion
R4695 T6995 T6996 det the,intestine
R4696 T6996 T6994 pobj intestine,of
R4697 T6997 T6996 amod small,intestine
R4698 T6999 T7000 punct (,A
R4699 T7000 T7001 meta A,type
R4700 T7002 T7000 punct ),A
R4701 T7003 T7001 amod Wild,type
R4702 T7004 T7001 prep on,type
R4703 T7005 T7006 det the,background
R4704 T7006 T7004 pobj background,on
R4705 T7007 T7006 compound B6,background
R4706 T7008 T7001 punct .,type
R4707 T7010 T7011 punct (,B
R4708 T7011 T7012 meta B,CF
R4709 T7013 T7011 punct ),B
R4710 T7014 T7012 prep on,CF
R4711 T7015 T7016 det the,background
R4712 T7016 T7014 pobj background,on
R4713 T7017 T7016 compound B6,background
R4714 T7018 T7012 punct .,CF
R4715 T7020 T7021 punct (,C
R4716 T7021 T7022 meta C,type
R4717 T7023 T7021 punct ),C
R4718 T7024 T7022 amod Wild,type
R4719 T7025 T7022 prep on,type
R4720 T7026 T7027 det the,background
R4721 T7027 T7025 pobj background,on
R4722 T7028 T7027 amod mixed,background
R4723 T7029 T7022 punct .,type
R4724 T7031 T7032 punct (,D
R4725 T7032 T7033 meta D,CF
R4726 T7034 T7032 punct -,D
R4727 T7035 T7032 dep F,D
R4728 T7036 T7032 punct ),D
R4729 T7037 T7033 prep on,CF
R4730 T7038 T7039 det the,background
R4731 T7039 T7037 pobj background,on
R4732 T7040 T7039 amod mixed,background
R4733 T7041 T7033 punct .,CF
R4734 T7043 T7044 punct (,A
R4735 T7044 T7045 meta A,are
R4736 T7046 T7044 punct ", ",A
R4737 T7047 T7044 dep C,A
R4738 T7048 T7044 punct ),A
R4739 T7049 T7045 prep In,are
R4740 T7050 T7051 det the,tissue
R4741 T7051 T7049 pobj tissue,In
R4742 T7052 T7053 amod wild,type
R4743 T7053 T7051 compound type,tissue
R4744 T7054 T7051 prep from,tissue
R4745 T7055 T7056 det both,backgrounds
R4746 T7056 T7054 pobj backgrounds,from
R4747 T7057 T7045 punct ", ",are
R4748 T7058 T7059 det the,crypts
R4749 T7059 T7045 nsubj crypts,are
R4750 T7060 T7045 acomp small,are
R4751 T7061 T7045 cc and,are
R4752 T7062 T7045 conj have,are
R4753 T7063 T7064 amod narrow,lumina
R4754 T7064 T7062 dobj lumina,have
R4755 T7065 T7066 punct (,arrows
R4756 T7066 T7062 parataxis arrows,have
R4757 T7067 T7066 punct ),arrows
R4758 T7068 T7045 punct .,are
R4759 T7070 T7071 punct (,B
R4760 T7071 T7072 meta B,are
R4761 T7073 T7071 punct ),B
R4762 T7074 T7072 prep In,are
R4763 T7075 T7076 det the,tissue
R4764 T7076 T7074 pobj tissue,In
R4765 T7077 T7076 compound CF,tissue
R4766 T7078 T7076 prep on,tissue
R4767 T7079 T7080 det the,background
R4768 T7080 T7078 pobj background,on
R4769 T7081 T7080 compound B6,background
R4770 T7082 T7072 punct ", ",are
R4771 T7083 T7084 det the,lumina
R4772 T7084 T7072 nsubj lumina,are
R4773 T7085 T7084 compound crypt,lumina
R4774 T7086 T7087 advmod greatly,dilated
R4775 T7087 T7072 acomp dilated,are
R4776 T7088 T7087 cc and,dilated
R4777 T7089 T7087 conj filled,dilated
R4778 T7090 T7089 prep with,filled
R4779 T7091 T7092 npadvmod PAS,reactive
R4780 T7092 T7094 amod reactive,mucus
R4781 T7093 T7092 punct -,reactive
R4782 T7094 T7090 pobj mucus,with
R4783 T7095 T7096 punct (,arrows
R4784 T7096 T7072 parataxis arrows,are
R4785 T7097 T7096 punct ),arrows
R4786 T7098 T7072 punct .,are
R4787 T7100 T7101 prep In,are
R4788 T7102 T7103 det some,mice
R4789 T7103 T7100 pobj mice,In
R4790 T7104 T7103 compound CF,mice
R4791 T7105 T7103 prep on,mice
R4792 T7106 T7107 det the,background
R4793 T7107 T7105 pobj background,on
R4794 T7108 T7107 amod mixed,background
R4795 T7109 T7101 punct ", ",are
R4796 T7110 T7111 det the,crypts
R4797 T7111 T7101 nsubj crypts,are
R4798 T7112 T7101 neg not,are
R4799 T7113 T7101 advmod apparently,are
R4800 T7114 T7101 acomp different,are
R4801 T7115 T7114 prep than,different
R4802 T7116 T7117 amod wild,type
R4803 T7117 T7115 pobj type,than
R4804 T7118 T7119 punct (,D
R4805 T7119 T7101 parataxis D,are
R4806 T7120 T7119 punct ),D
R4807 T7121 T7101 punct ", ",are
R4808 T7122 T7101 cc and,are
R4809 T7123 T7124 det the,crypts
R4810 T7124 T7125 nsubj crypts,are
R4811 T7125 T7101 conj are,are
R4812 T7126 T7127 amod normal,appearing
R4813 T7127 T7125 acomp appearing,are
R4814 T7128 T7129 punct (,arrows
R4815 T7129 T7125 parataxis arrows,are
R4816 T7130 T7129 punct ),arrows
R4817 T7131 T7101 punct .,are
R4818 T7133 T7134 det Some,mice
R4819 T7134 T7136 nsubj mice,had
R4820 T7135 T7134 compound CF,mice
R4821 T7137 T7134 prep on,mice
R4822 T7138 T7139 det the,background
R4823 T7139 T7137 pobj background,on
R4824 T7140 T7139 amod mixed,background
R4825 T7141 T7142 advmod mildly,crypts
R4826 T7142 T7136 dobj crypts,had
R4827 T7143 T7142 amod affected,crypts
R4828 T7144 T7145 punct (,E
R4829 T7145 T7136 parataxis E,had
R4830 T7146 T7145 punct ),E
R4831 T7147 T7136 punct ", ",had
R4832 T7148 T7149 mark while,had
R4833 T7149 T7136 advcl had,had
R4834 T7150 T7149 nsubj others,had
R4835 T7151 T7152 amod greater,dilation
R4836 T7152 T7149 dobj dilation,had
R4837 T7153 T7152 compound crypt,dilation
R4838 T7154 T7152 cc and,dilation
R4839 T7155 T7156 compound mucus,accumulation
R4840 T7156 T7152 conj accumulation,dilation
R4841 T7157 T7158 punct (,F
R4842 T7158 T7149 parataxis F,had
R4843 T7159 T7158 punct ),F
R4844 T7160 T7136 punct .,had
R4845 T7162 T7163 advmod Overall,affected
R4846 T7164 T7163 punct ", ",affected
R4847 T7165 T7166 det the,mice
R4848 T7166 T7163 nsubjpass mice,affected
R4849 T7167 T7166 compound CF,mice
R4850 T7168 T7166 prep on,mice
R4851 T7169 T7170 det the,background
R4852 T7170 T7168 pobj background,on
R4853 T7171 T7170 amod mixed,background
R4854 T7172 T7163 auxpass were,affected
R4855 T7173 T7174 advmod less,severely
R4856 T7174 T7163 advmod severely,affected
R4857 T7175 T7163 prep compared,affected
R4858 T7176 T7175 prep to,compared
R4859 T7177 T7176 pobj those,to
R4860 T7178 T7177 prep on,those
R4861 T7179 T7180 det the,background
R4862 T7180 T7178 pobj background,on
R4863 T7181 T7180 compound B6,background
R4864 T7182 T7163 punct .,affected
R4865 T7232 T7231 prep of,Effect
R4866 T7233 T7234 amod genetic,background
R4867 T7234 T7232 pobj background,of
R4868 T7235 T7231 prep on,Effect
R4869 T7236 T7237 compound CF,survival
R4870 T7237 T7235 pobj survival,on
R4871 T7238 T7237 compound mouse,survival
R4872 T7239 T7237 prep on,survival
R4873 T7240 T7241 amod solid,chow
R4874 T7241 T7239 pobj chow,on
R4875 T7242 T7231 punct .,Effect
R4876 T7244 T7245 nsubjpass Mice,maintained
R4877 T7246 T7245 auxpass were,maintained
R4878 T7247 T7245 prep on,maintained
R4879 T7248 T7249 det the,diet
R4880 T7249 T7247 pobj diet,on
R4881 T7250 T7249 compound liquid,diet
R4882 T7251 T7252 punct (,Peptamen
R4883 T7252 T7249 parataxis Peptamen,diet
R4884 T7253 T7252 punct ),Peptamen
R4885 T7254 T7245 prep until,maintained
R4886 T7255 T7256 nummod 8,weeks
R4887 T7256 T7254 pobj weeks,until
R4888 T7257 T7256 prep of,weeks
R4889 T7258 T7257 pobj age,of
R4890 T7259 T7256 punct ", ",weeks
R4891 T7260 T7261 prep at,fed
R4892 T7261 T7256 advcl fed,weeks
R4893 T7262 T7263 det which,time
R4894 T7263 T7260 pcomp time,at
R4895 T7264 T7261 nsubjpass they,fed
R4896 T7265 T7261 auxpass were,fed
R4897 T7266 T7267 amod standard,chow
R4898 T7267 T7261 dobj chow,fed
R4899 T7268 T7267 amod solid,chow
R4900 T7269 T7267 compound mouse,chow
R4901 T7270 T7261 prep for,fed
R4902 T7271 T7272 quantmod up,8
R4903 T7272 T7274 nummod 8,weeks
R4904 T7273 T7272 quantmod to,8
R4905 T7274 T7270 pobj weeks,for
R4906 T7275 T7274 amod additional,weeks
R4907 T7276 T7245 punct .,maintained
R4908 T7278 T7279 nsubjpass Deaths,recorded
R4909 T7280 T7279 auxpass were,recorded
R4910 T7281 T7282 mark as,occurred
R4911 T7282 T7279 advcl occurred,recorded
R4912 T7283 T7282 nsubj they,occurred
R4913 T7284 T7279 cc and,recorded
R4914 T7285 T7286 nsubjpass mice,sacrificed
R4915 T7286 T7279 conj sacrificed,recorded
R4916 T7287 T7285 prep in,mice
R4917 T7288 T7289 amod obvious,distress
R4918 T7289 T7287 pobj distress,in
R4919 T7290 T7286 auxpass were,sacrificed
R4920 T7291 T7286 cc and,sacrificed
R4921 T7292 T7293 punct ',recorded
R4922 T7293 T7286 conj recorded,sacrificed
R4923 T7294 T7293 nsubj death,recorded
R4924 T7295 T7293 punct ',recorded
R4925 T7296 T7293 prep as,recorded
R4926 T7297 T7298 det the,day
R4927 T7298 T7296 pobj day,as
R4928 T7299 T7298 amod subsequent,day
R4929 T7300 T7286 punct .,sacrificed
R4930 T7302 T7303 prep By,had
R4931 T7304 T7305 compound log,rank
R4932 T7305 T7307 compound rank,test
R4933 T7306 T7305 punct -,rank
R4934 T7307 T7302 pobj test,By
R4935 T7308 T7303 punct ", ",had
R4936 T7309 T7310 compound CF,mice
R4937 T7310 T7303 nsubj mice,had
R4938 T7311 T7310 prep on,mice
R4939 T7312 T7313 det the,background
R4940 T7313 T7311 pobj background,on
R4941 T7314 T7313 amod mixed,background
R4942 T7315 T7316 advmod significantly,earlier
R4943 T7316 T7317 amod earlier,death
R4944 T7317 T7303 dobj death,had
R4945 T7318 T7317 prep compared,death
R4946 T7319 T7318 prep to,compared
R4947 T7320 T7321 amod wild,type
R4948 T7321 T7319 pobj type,to
R4949 T7322 T7323 punct (,0.035
R4950 T7323 T7317 parataxis 0.035,death
R4951 T7324 T7323 nsubj P,0.035
R4952 T7325 T7323 punct =,0.035
R4953 T7326 T7323 punct ),0.035
R4954 T7327 T7317 punct ", ",death
R4955 T7328 T7317 cc and,death
R4956 T7329 T7330 advmod significantly,death
R4957 T7330 T7317 conj death,death
R4958 T7331 T7330 amod later,death
R4959 T7332 T7330 prep than,death
R4960 T7333 T7334 compound CF,mice
R4961 T7334 T7332 pobj mice,than
R4962 T7335 T7334 prep on,mice
R4963 T7336 T7337 det the,background
R4964 T7337 T7335 pobj background,on
R4965 T7338 T7337 compound B6,background
R4966 T7339 T7340 punct (,0.025
R4967 T7340 T7330 parataxis 0.025,death
R4968 T7341 T7340 nsubj P,0.025
R4969 T7342 T7340 punct =,0.025
R4970 T7343 T7340 punct ),0.025
R4971 T7344 T7303 punct .,had
R4972 T7346 T7347 compound CF,mice
R4973 T7347 T7348 nsubj mice,died
R4974 T7349 T7347 prep on,mice
R4975 T7350 T7351 det the,background
R4976 T7351 T7349 pobj background,on
R4977 T7352 T7351 compound B6,background
R4978 T7353 T7348 advmod also,died
R4979 T7354 T7355 advmod significantly,earlier
R4980 T7355 T7348 advcl earlier,died
R4981 T7356 T7355 prep than,earlier
R4982 T7357 T7358 amod wild,type
R4983 T7358 T7356 pobj type,than
R4984 T7359 T7360 punct (,0.0005
R4985 T7360 T7348 parataxis 0.0005,died
R4986 T7361 T7360 nsubj P,0.0005
R4987 T7362 T7360 punct <,0.0005
R4988 T7363 T7360 punct ),0.0005
R4989 T7364 T7348 punct .,died
R4990 T7376 T7375 prep of,Distribution
R4991 T7377 T7378 compound Cftr,genotypes
R4992 T7378 T7376 pobj genotypes,of
R4993 T7379 T7375 prep in,Distribution
R4994 T7380 T7381 amod female,offspring
R4995 T7381 T7379 pobj offspring,in
R4996 T7382 T7381 prep from,offspring
R4997 T7383 T7382 pcomp breeding,from
R4998 T7384 T7385 compound Cftr,heterozygotes
R4999 T7385 T7383 dobj heterozygotes,breeding
R5000 T7386 T7383 prep on,breeding
R5001 T7387 T7388 det the,backgrounds
R5002 T7388 T7386 pobj backgrounds,on
R5003 T7389 T7388 nmod B6,backgrounds
R5004 T7390 T7389 cc and,B6
R5005 T7391 T7389 conj mixed,B6
R5006 T7392 T7375 punct .,Distribution
R5007 T7404 T7403 prep of,Distribution
R5008 T7405 T7406 compound Cftr,genotypes
R5009 T7406 T7404 pobj genotypes,of
R5010 T7407 T7403 prep in,Distribution
R5011 T7408 T7409 amod male,offspring
R5012 T7409 T7407 pobj offspring,in
R5013 T7410 T7409 prep from,offspring
R5014 T7411 T7410 pcomp breeding,from
R5015 T7412 T7413 compound Cftr,heterozygotes
R5016 T7413 T7411 dobj heterozygotes,breeding
R5017 T7414 T7411 prep on,breeding
R5018 T7415 T7416 det the,backgrounds
R5019 T7416 T7414 pobj backgrounds,on
R5020 T7417 T7416 nmod B6,backgrounds
R5021 T7418 T7417 cc and,B6
R5022 T7419 T7417 conj mixed,B6
R5023 T7420 T7403 punct .,Distribution
R5024 T7426 T7427 compound Genome,analysis
R5025 T7428 T7427 compound scanning,analysis
R5026 T7429 T7427 prep of,analysis
R5027 T7430 T7431 compound CF,mice
R5028 T7431 T7429 pobj mice,of
R5029 T7432 T7431 prep on,mice
R5030 T7433 T7434 det the,background
R5031 T7434 T7432 pobj background,on
R5032 T7435 T7434 amod mixed,background
R5033 T7436 T7427 punct .,analysis
R2315 T3503 T3496 punct ", ",was
R2316 T3504 T3505 det the,distribution
R2317 T3505 T3496 nsubj distribution,was
R2318 T3506 T3505 prep of,distribution
R2319 T3507 T3506 pobj genotypes,of
R2320 T3508 T3507 prep of,genotypes
R2321 T3509 T3510 amod female,offspring
R2322 T3510 T3508 pobj offspring,of
R2323 T3511 T3496 neg not,was
R2324 T3512 T3513 advmod significantly,different
R2325 T3513 T3496 acomp different,was
R2326 T3514 T3513 prep from,different
R2327 T3515 T3516 det the,expected
R2328 T3516 T3514 pobj expected,from
R2329 T3517 T3518 punct (,Tables
R2330 T3518 T3513 parataxis Tables,different
R2331 T3519 T3518 nummod 1,Tables
R2332 T3520 T3518 punct ),Tables
R2333 T3521 T3496 punct .,was
R2334 T3523 T3524 prep For,was
R2376 T3569 T3570 det "Table 1 Distribution of Cftr genotypes in female offspring from breeding Cftr heterozygotes on the B6 and mixed backgrounds. B6 Background Mixed Background Cftr Observed Expected Observed Expected +/+ 207 175 57 47 +/- 371 350 88 94 -/- 122 175 42 47 P 0.00001 (0.04533)* 0.21724 Statistical analysis was by Chi-square. (*) P-value if the sample size for the B6 mice is adjusted to be equal to that of the mixed background mice, assuming the same distribution of genotypes. Table 2 Distribution of Cftr genotypes in male offspring from breeding Cftr heterozygotes on the B6 and mixed backgrounds. B6 Background Mixed Background Cftr Observed Expected Observed Expected +/+ 240 201 57 52 +/- 431 403 115 104 -/- 134 201 36 52 P <0.00001 (0.01612)* 0.03749 Statistical analysis was by Chi-square. (*) P-value if the sample size for the B6 mice is adjusted to be equal to that of the mixed background mice, assuming the same distribution of genotypes. The",cause
R2377 T3570 T3572 nsubj cause,is
R2378 T3571 T3570 amod major,cause
R2379 T3573 T3570 prep of,cause
R2380 T3574 T3573 pobj death,of
R2381 T3575 T3570 prep in,cause
R2382 T3576 T3577 compound CF,mice
R2383 T3577 T3575 pobj mice,in
R2384 T3578 T3579 amod intestinal,obstruction
R2385 T3579 T3572 attr obstruction,is
R2386 T3580 T3572 punct ", ",is
R2387 T3581 T3572 cc and,is
R2388 T3582 T3583 amod intestinal,obstruction
R2389 T3583 T3584 nsubjpass obstruction,worsened
R2390 T3584 T3572 conj worsened,is
R2391 T3585 T3584 auxpass is,worsened
R1 T139 T140 amod Potential,modifiers
R2 T142 T140 amod genetic,modifiers
R3 T143 T140 prep of,modifiers
R4 T144 T145 det the,phenotype
R10 T150 T140 prep on,modifiers
R11 T151 T152 nmod mouse,1
R20 T165 T166 amod cystic,fibrosis
R21 T166 T164 nsubjpass fibrosis,caused
R22 T167 T164 auxpass is,caused
R28 T174 T175 amod cystic,regulator
R33 T179 T175 punct (,regulator
R34 T180 T175 appos CFTR,regulator
R35 T181 T173 punct ),gene
R68 T216 T215 compound mucus,accumulation
R81 T229 T228 amod intestinal,obstruction
R91 T241 T240 amod genetic,background
R99 T251 T250 nmod C57Bl,background
R100 T252 T251 punct /,C57Bl
R101 T253 T251 nummod 6,C57Bl
R113 T265 T264 compound mouse,chow
R120 T272 T271 amod small,intestine
R138 T292 T291 compound modifier,loci
R142 T296 T295 nmod CF,phenotype
R143 T297 T295 amod intestinal,phenotype
R151 T309 T308 amod mixed,background
R152 T310 T308 amod genetic,background
R155 T313 T312 nummod 95,C57Bl
R156 T314 T313 quantmod %,95
R162 T320 T318 quantmod %,5
R172 T330 T329 nmod C57Bl,background
R173 T331 T330 punct /,C57Bl
R174 T332 T330 nummod 6,C57Bl
R181 T339 T338 amod intestinal,phenotype
R182 T340 T338 compound CF,phenotype
R189 T349 T348 amod mixed,background
R197 T357 T356 compound mouse,chow
R202 T362 T361 amod intestinal,inflammation
R208 T368 T367 compound RT,PCR
R209 T369 T367 punct -,PCR
R218 T378 T379 compound body,weight
R219 T379 T377 compound weight,gain
R225 T385 T384 compound mucus,accumulation
R229 T389 T388 amod intestinal,crypts
R238 T400 T399 compound gender,effect
R242 T404 T403 compound weight,gain
R249 T411 T410 amod significant,improvement
R267 T429 T428 nsubj females,showed
R273 T435 T433 cc and,4
R274 T436 T433 conj 8,4
R279 T443 T442 amod preliminary,scanning
R280 T444 T445 npadvmod genome,wide
R283 T447 T448 compound PCR,allele
R284 T448 T442 compound allele,scanning
R291 T455 T454 auxpass be,associated
R292 T456 T454 advmod potentially,associated
R296 T460 T459 amod milder,phenotype
R328 T497 T496 compound modifier,regions
R334 T504 T503 amod positive,impact
R338 T508 T507 amod inflammatory,phenotype
R342 T512 T513 nmod CF,mouse
R343 T513 T511 nmod mouse,intestine
R344 T514 T511 amod small,intestine
R361 T533 T532 amod new,information
R368 T540 T539 nmod CF,phenotype
R369 T541 T539 amod intestinal,phenotype
R2000 T3087 T3084 punct ", ",had
R2001 T3088 T3089 nsubj one,had
R2002 T3089 T3084 conj had,had
R2003 T3090 T3091 det some,mucus
R2004 T3091 T3089 dobj mucus,had
R2005 T3092 T3089 punct ", ",had
R2006 T3093 T3089 cc and,had
R2007 T3094 T3095 nsubj two,had
R2008 T3095 T3089 conj had,had
R2009 T3096 T3097 amod moderate,amounts
R2010 T3097 T3095 dobj amounts,had
R2011 T3098 T3097 prep of,amounts
R2012 T3099 T3098 pobj mucus,of
R2013 T3100 T3084 punct .,had
R2014 T3102 T3103 prep Despite,had
R2015 T3104 T3105 det the,variability
R2016 T3105 T3102 pobj variability,Despite
R2017 T3106 T3103 punct ", ",had
R2018 T3107 T3108 predet all,mice
R2019 T3108 T3103 nsubj mice,had
R2020 T3109 T3108 det the,mice
R2021 T3110 T3108 compound CF,mice
R2022 T3111 T3108 prep on,mice
R2023 T3112 T3113 det the,background
R2024 T3113 T3111 pobj background,on
R2025 T3114 T3113 amod mixed,background
R2026 T3115 T3116 amod less,dilation
R2027 T3116 T3103 dobj dilation,had
R2028 T3117 T3116 compound crypt,dilation
R2029 T3118 T3116 cc and,dilation
R2030 T3119 T3120 amod less,accumulation
R2031 T3120 T3116 conj accumulation,dilation
R2032 T3121 T3120 compound mucus,accumulation
R2033 T3122 T3103 prep compared,had
R2034 T3123 T3122 prep to,compared
R2035 T3124 T3125 compound CF,mice
R2036 T3125 T3123 pobj mice,to
R2037 T3126 T3125 prep on,mice
R2038 T3127 T3128 det the,background
R2042 T3132 T3133 advmod Thus,appears
R2043 T3134 T3133 punct ", ",appears
R2044 T3135 T3133 nsubj it,appears
R2045 T3136 T3137 mark that,affect
R2046 T3137 T3133 ccomp affect,appears
R1665 T2528 T2529 advmod almost,20-fold
R1666 T2529 T2524 advmod 20-fold,overexpressed
R1667 T2530 T2524 prep in,overexpressed
R1668 T2531 T2532 compound B6,mice
R1669 T2532 T2530 pobj mice,in
R1670 T2533 T2532 compound CF,mice
R1671 T2534 T2524 prep compared,overexpressed
R1672 T2535 T2534 prep to,compared
R1673 T2536 T2537 amod wild,type
R1674 T2537 T2535 pobj type,to
R1675 T2538 T2524 punct ", ",overexpressed
R1676 T2539 T2524 cc and,overexpressed
R1677 T2540 T2541 prep on,was
R1678 T2541 T2524 conj was,overexpressed
R1679 T2542 T2543 det the,background
R1680 T2543 T2540 pobj background,on
R1681 T2544 T2543 amod mixed,background
R1682 T2545 T2546 det the,level
R1683 T2546 T2541 nsubj level,was
R1684 T2547 T2546 compound CF,level
R1685 T2548 T2546 compound expression,level
R1686 T2549 T2541 neg not,was
R1687 T2550 T2551 advmod statistically,different
R1688 T2551 T2541 acomp different,was
R1689 T2552 T2551 prep from,different
R1690 T2553 T2554 amod wild,type
R1691 T2554 T2552 pobj type,from
R1692 T2555 T2556 punct (,Fig.
R1693 T2556 T2541 parataxis Fig.,was
R1694 T2557 T2556 nummod 2F,Fig.
R1695 T2558 T2556 punct ),Fig.
R1696 T2559 T2541 punct .,was
R379 T786 T787 amod Cystic,fibrosis
R380 T787 T788 nsubjpass fibrosis,caused
R381 T789 T787 punct (,fibrosis
R382 T790 T787 appos CF,fibrosis
R383 T791 T788 punct ),caused
R384 T792 T788 auxpass is,caused
R385 T793 T788 agent by,caused
R386 T794 T793 pobj mutations,by
R387 T795 T794 prep in,mutations
R388 T796 T797 det the,gene
R389 T797 T795 pobj gene,in
R390 T798 T799 amod cystic,fibrosis
R391 T799 T800 nmod fibrosis,regulator
R392 T800 T797 nmod regulator,gene
R393 T801 T802 amod transmembrane,conductance
R2772 T4548 T4545 npadvmod cM,chr.10
R2773 T4549 T4550 punct (,had
R2774 T4550 T4545 parataxis had,chr.10
R2775 T4551 T4552 nummod 10,mice
R2776 T4552 T4550 nsubj mice,had
R2777 T4553 T4554 preconj both,B6
R2778 T4554 T4555 nmod B6,alleles
R2779 T4555 T4550 dobj alleles,had
R2780 T4556 T4554 cc and,B6
R2781 T4557 T4554 conj 129,B6
R2782 T4558 T4550 punct ),had
R2783 T4559 T4505 punct .,were
R2784 T4562 T4563 nmod B,e
R2785 T4570 T4569 det the,s
R2786 T4573 T4572 nsubjpass p,a
R2787 T4575 T4576 mark c,was
R2788 T4576 T4581 advcl was,looked
R2789 T4577 T4576 nsubj ing,was
R2790 T4578 T4577 prep of,ing
R2791 T4579 T4578 pobj markers,of
R2792 T4580 T4579 acl used,markers
R2793 T4582 T4583 quantmod about,12
R2794 T4583 T4584 nummod 12,cM
R2795 T4584 T4576 attr cM,was
R2796 T4585 T4581 punct ", ",looked
R2797 T4586 T4581 nsubjpass genes,looked
R2798 T4587 T4586 prep within,genes
R2799 T4588 T4589 nummod 75,%
R2800 T4589 T4587 pobj %,within
R2801 T4590 T4589 prep of,%
R2802 T4591 T4592 det this,interval
R2803 T4592 T4590 pobj interval,of
R2804 T4593 T4586 prep on,genes
R2805 T4594 T4595 det either,side

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T6471 27544-27552 OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process denotes genetics
T6470 27495-27499 NCBITaxon:10088 denotes mice
T6469 27492-27493 SO_EXT:sequence_nullness_or_absence denotes -
T6468 27490-27491 SO_EXT:normal_or_wild_type_or_present denotes +
T6467 27485-27489 PR_EXT:000001044 denotes Cftr
T6466 27476-27484 GO_EXT:breeding denotes breeding
T6465 27445-27449 NCBITaxon_UBERON_EXT:pup denotes pups
T6464 27432-27441 SO_EXT:genotype_or_entity_with_genotype denotes genotypes
T6463 27227-27231 UBERON_EXT:body denotes body
T6462 27207-27222 GO:0010467 denotes Gene expression
T6461 27207-27211 SO_EXT:0000704 denotes Gene
T6389 27146-27159 CHEBI:29149 denotes periodic acid
T6388 27000-27007 UBERON:0000479 denotes tissues
T6387 26978-26994 CHEBI_EXT:paraformaldehye denotes paraformaldehyde
T6386 26935-26941 CHEBI_EXT:saline_solution denotes saline
T6385 26926-26934 CHEBI_CHMO_EXT:buffer_process denotes buffered
T6384 26916-26925 CHEBI_EXT:phosphate denotes phosphate
T7220 17118-17122 NCBITaxon:10088 denotes mice
T7219 17076-17082 GO:0016265 denotes Deaths
T7218 17041-17045 CHEBI_EXT:33290 denotes chow
T7217 17035-17040 NCBITaxon:10088 denotes mouse
T7216 17016-17019 GO:0007631 denotes fed
T7215 16919-16923 NCBITaxon:10088 denotes Mice
T7214 16913-16917 CHEBI_EXT:33290 denotes chow
T7213 16889-16894 NCBITaxon:10088 denotes mouse
T7212 16864-16871 SO_EXT:0000704 denotes genetic
T7230 17463-17472 SO_EXT:wild_type_entity_or_quality denotes wild type
T7229 17431-17435 GO:0016265 denotes died
T7228 17400-17404 NCBITaxon:10088 denotes mice
T7227 17358-17362 NCBITaxon:10088 denotes mice
T7226 17344-17349 GO:0016265 denotes death
T7225 17297-17306 SO_EXT:wild_type_entity_or_quality denotes wild type
T7224 17279-17284 GO:0016265 denotes death
T7223 17224-17228 NCBITaxon:10088 denotes mice
T7222 17164-17169 GO:0016265 denotes death
T7221 17148-17158 GO_EXT:killing denotes sacrificed
T6252 26859-26866 SO_EXT:0000132 denotes primers
T6251 26816-26823 _FRAGMENT denotes reverse
T6250 26859-26866 SO_EXT:0000121 denotes primers
T6249 26769-26776 _FRAGMENT denotes forward
T6248 26735-26739 PR_EXT:000010764 denotes Muc2
T6247 26717-26727 UBERON:0000160 denotes intestinal
T6246 26693-26703 GO:0010467 denotes Expression
T6245 26671-26686 UBERON:0002108 denotes small intestine
T6244 26665-26670 NCBITaxon:10088 denotes mouse
T6243 26635-26639 SO_EXT:0000704 denotes gene
T6242 26603-26613 GO:0010467 denotes expression
T6241 26594-26598 CHEBI_SO_EXT:mRNA denotes mRNA
T6240 26588-26593 GO_PR_EXT:glyceraldehyde_3_phosphate_dehydrogenase denotes GAPDH
T6239 26548-26555 SO_EXT:0000112 denotes primers
T6238 26511-26516 SO_EXT:0000704 denotes genes
T6237 26488-26498 GO:0010467 denotes expression
T6236 26461-26463 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T6235 26391-26406 UBERON:0002108 denotes small intestine
T6234 26357-26360 CHEBI_SO_EXT:RNA denotes RNA
T6233 26335-26350 GO:0010467 denotes gene expression
T6232 26335-26339 SO_EXT:0000704 denotes gene
T6096 26308-26317 GO:0030849 denotes autosomes
T6095 26252-26259 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T6094 26188-26195 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T6093 26140-26147 SO_EXT:0001023 denotes alleles
T6092 26101-26108 SO_EXT:0000112 denotes primers
T6091 26068-26072 SO_EXT:0000207 denotes SSLP
T6090 26031-26066 SO_EXT:0000207 denotes simple sequence length polymorphism
T6089 25986-25990 UBERON:0002415 denotes tail
T6088 25980-25985 NCBITaxon:10088 denotes mouse
T6087 25964-25968 NCBITaxon:10088 denotes mice
T6086 25959-25963 GO_EXT:breeding denotes bred
T6085 25810-25816 SO_EXT:0001026 denotes Genome
T6084 25773-25780 SO_EXT:0000704 denotes Genetic
T5468 24124-24134 UBERON:0000160 denotes intestinal
T5467 24101-24106 SO_EXT:0000704 denotes genes
T5466 24078-24088 GO:0010467 denotes expression
T5465 24052-24065 SO_EXT:polymorphism denotes polymorphisms
T5464 23906-23914 GO_PATO_EXT:biological_behavior denotes behavior
T5463 23875-23885 CL:0000775 denotes neutrophil
T5462 23886-23901 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T5461 23866-23870 _FRAGMENT denotes cell
T5460 23866-23870 CL_GO_EXT:cell denotes cell
T5459 23861-23870 CL:0000097 denotes mast cell
T5458 23807-23812 SO_EXT:0000704 denotes genes
T5457 23792-23801 GO_EXT:secretion_entity_or_process denotes secretion
T5456 23786-23791 UBERON:0000912 denotes mucus
T5455 23777-23782 CL_GO_EXT:cell denotes cells
T5454 23770-23782 CL:0000738 denotes immune cells
T5453 23770-23776 UBERON:0002405 denotes immune
T5452 23725-23740 UBERON:0002108 denotes small intestine
T5451 23702-23714 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammation
T5450 23596-23611 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes regions on chr.
T5449 23553-23560 SO_EXT:0001023 denotes alleles
T5448 23512-23516 NCBITaxon:10088 denotes mice
T5447 23466-23478 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T5707 25619-25623 NCBITaxon:10088 denotes Mice
T5706 25582-25586 NCBITaxon:10088 denotes mice
T5705 25575-25581 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T5704 25566-25570 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes Male
T5703 25526-25530 CHEBI_EXT:33290 denotes chow
T5702 25499-25509 GO_EXT:killing denotes sacrificed
T5701 25466-25470 NCBITaxon:10088 denotes Mice
T5700 25413-25417 CHEBI_EXT:33290 denotes chow
T5699 25407-25412 NCBITaxon:10088 denotes mouse
T5698 25384-25395 GO_EXT:biological_movement_or_translocation_process denotes transferred
T5697 25374-25378 NCBITaxon:10088 denotes mice
T5696 25286-25295 SO_EXT:wild_type_entity_or_quality denotes Wild type
T5695 25275-25279 NCBITaxon:10088 denotes mice
T5694 25234-25244 UBERON:0000160 denotes intestinal
T5693 25133-25137 NCBITaxon:10088 denotes mice
T5692 25033-25037 NCBITaxon:10088 denotes Mice
T5691 25028-25029 SO_EXT:sequence_nullness_or_absence denotes -
T5690 25026-25027 SO_EXT:sequence_nullness_or_absence denotes -
T5689 25021-25025 PR_EXT:000001044 denotes Cftr
T5688 25015-25019 SO_EXT:sequence_nullness denotes null
T5687 24999-25003 PR_EXT:000001044 denotes Cftr
T5686 24992-24993 SO_EXT:normal_or_wild_type_or_present denotes +
T5685 24990-24991 SO_EXT:normal_or_wild_type_or_present denotes +
T5684 24985-24989 PR_EXT:000001044 denotes Cftr
T5683 24974-24983 SO_EXT:wild_type_entity_or_quality denotes wild type
T5682 24958-24962 PR_EXT:000001044 denotes Cftr
T5681 24939-24946 SO_EXT:0001023 denotes alleles
T5680 24931-24938 CHEBI_PR_EXT:gastrin denotes gastrin
T5679 24912-24921 SO_EXT:wild_type_entity_or_quality denotes wild type
T5678 24907-24911 NCBITaxon:10088 denotes mice
T5677 24892-24896 GO_EXT:breeding denotes bred
T5676 24882-24886 NCBITaxon:10088 denotes mice
T5675 24829-24833 NCBITaxon:10088 denotes mice
T5674 24787-24793 SO_EXT:0001026 denotes genome
T5673 24749-24753 NCBITaxon:10088 denotes mice
T5672 24746-24747 SO_EXT:sequence_nullness_or_absence denotes -
T5671 24744-24745 SO_EXT:normal_or_wild_type_or_present denotes +
T5670 24739-24743 PR_EXT:000001044 denotes Cftr
T5669 24691-24695 NCBITaxon:10088 denotes mice
T5668 24688-24689 SO_EXT:sequence_nullness_or_absence denotes -
T5667 24686-24687 SO_EXT:normal_or_wild_type_or_present denotes +
T5666 24678-24685 CHEBI_PR_EXT:gastrin denotes gastrin
T5665 24623-24627 GO_EXT:breeding denotes bred
T5664 24579-24583 SO_EXT:0000704 denotes gene
T5663 24571-24578 CHEBI_PR_EXT:gastrin denotes gastrin
T5662 24555-24563 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5661 24530-24534 NCBITaxon:10088 denotes Mice
T5660 24435-24439 NCBITaxon:10088 denotes mice
T5659 24222-24229 SO_EXT:0000704 denotes genetic
T5658 24200-24204 NCBITaxon:10088 denotes mice
T5657 24195-24199 SO_EXT:sequence_nullness denotes null
T5656 24190-24194 PR_EXT:000001044 denotes Cftr
T5655 24176-24185 SO_EXT:wild_type_entity_or_quality denotes Wild type
T5654 24168-24175 NCBITaxon:33208 denotes Animals
T4291 23408-23417 GO_EXT:secretion_entity_or_process denotes secretion
T4290 23402-23407 UBERON:0000912 denotes mucus
T4289 23348-23362 CHEBI:26333 denotes prostaglandins
T4288 23337-23346 GO_EXT:0008233 denotes proteases
T4287 23326-23335 CHEBI:18295 denotes histamine
T4286 23313-23324 CL:0000775 denotes neutrophils
T4285 23303-23308 CL_GO_EXT:cell denotes cells
T4284 23298-23308 CL:0000097 denotes mast cells
T4283 23286-23294 GO_EXT:biological_release denotes released
T4282 23276-23285 CHEBI:36357 denotes molecules
T4281 23267-23275 CHEBI_EXT:35224 denotes effector
T4280 23227-23232 UBERON:0000912 denotes mucus
T4279 23214-23223 GO_EXT:secretion_entity_or_process denotes secretion
T4278 23165-23171 UBERON:0000062 denotes organs
T4277 23146-23152 GO_UBERON_EXT:lumen denotes lumina
T4276 23120-23126 CHEBI_EXT:37527 denotes acidic
T4275 23099-23108 GO_EXT:secretion_entity_or_process denotes secretion
T4274 23093-23098 UBERON:0006314 denotes fluid
T4273 23051-23058 UBERON:0000479 denotes tissues
T4272 23012-23017 UBERON:0000912 denotes mucus
T4271 22983-22992 UBERON:0000160 denotes intestine
T4270 22954-22959 UBERON:0000912 denotes mucus
T4269 22908-22924 GO:0006955 denotes immune responses
T4268 22908-22914 UBERON:0002405 denotes immune
T4267 22892-22898 UBERON:0000479 denotes tissue
T4266 22883-22891 GO_PATO_EXT:inflammatory_process_or_quality denotes inflamed
T4265 22841-22852 CL:0000775 denotes neutrophils
T4264 22824-22852 GO:0072672 denotes extravasation of neutrophils
T4263 22798-22806 CHEBI_PR_EXT:protein denotes proteins
T4262 22766-22771 PR_EXT:000001467 denotes Icam1
T4261 22752-22761 PR_EXT:selectin denotes selectins
T4260 22736-22747 CL:0000775 denotes neutrophils
T4259 22714-22719 PR_EXT:000010903 denotes Mcpt2
T4258 22700-22710 GO:0010467 denotes expression
T4257 22648-22653 CL_GO_EXT:cell denotes cells
T4256 22643-22653 CL:0000097 denotes mast cells
T4255 22591-22595 NCBITaxon:10088 denotes mice
T4254 22577-22582 CL_GO_EXT:cell denotes cells
T4253 22572-22582 CL:0000097 denotes mast cells
T4252 22577-22582 GO:0030154 denotes cells
T4251 22553-22571 _FRAGMENT denotes differentiation of
T4250 22533-22537 SO_EXT:0000704 denotes gene
T4249 22528-22532 PR_EXT:000009345 denotes Kitl
T4248 22493-22498 CL_GO_EXT:cell denotes cells
T4247 22469-22474 SO_EXT:0000704 denotes genes
T4246 22452-22463 CL:0000775 denotes neutrophils
T4245 22442-22447 CL_GO_EXT:cell denotes cells
T4244 22437-22447 CL:0000097 denotes mast cells
T4243 22402-22408 UBERON:0002405 denotes immune
T4242 22390-22417 GO:0045087 denotes innate type immune response
T4241 22346-22356 UBERON:0000160 denotes intestinal
T4240 22340-22345 NCBITaxon:10088 denotes mouse
T4239 22272-22277 SO_EXT:0000704 denotes genes
T4238 22229-22233 GO_SO_EXT:chromosome denotes chr.
T4237 22205-22209 UBERON_EXT:body denotes body
T4236 22199-22204 GO:0007567 denotes natal
T4235 22169-22173 GO_SO_EXT:chromosome denotes chr.
T4234 22151-22157 GO_EXT:biological_growth_entity_or_process denotes growth
T4233 22146-22150 UBERON_EXT:body denotes body
T4232 22126-22130 GO_SO_EXT:chromosome denotes chr.
T4231 22109-22113 UBERON_EXT:body denotes body
T4230 22087-22091 GO_SO_EXT:chromosome denotes chr.
T4229 22072-22076 UBERON_EXT:body denotes body
T4228 22046-22050 GO_SO_EXT:chromosome denotes chr.
T4227 22029-22033 UBERON_EXT:body denotes body
T4226 22008-22012 GO_SO_EXT:chromosome denotes chr.
T4225 21975-21979 GO_SO_EXT:chromosome denotes chr.
T4224 21960-21964 UBERON_EXT:body denotes body
T4223 21954-21959 NCBITaxon:10088 denotes mouse
T4222 21931-21935 UBERON_EXT:body denotes body
T4221 21911-21914 SO_EXT:0000771 denotes QTL
T4220 21887-21894 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T4219 21828-21836 CL_GO_EXT:cell denotes cellular
T4218 21823-21855 GO:0035556 denotes intracellular signaling pathways
T4217 21823-21836 GO:0005622 denotes intracellular
T4216 21774-21778 GO_SO_EXT:chromosome denotes chr.
T4215 21767-21772 SO_EXT:0000704 denotes genes
T4214 21755-21760 PR_EXT:000002088 denotes Stat2
T4213 21703-21715 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T4212 21716-21740 PR_EXT:000001335 denotes IL-10 interleukin family
T4211 21684-21693 _FRAGMENT denotes member of
T4210 21666-21670 GO_SO_EXT:chromosome denotes chr.
T4209 21660-21664 PR_EXT:000001383 denotes Il22
T4208 21600-21612 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T4207 21563-21567 GO_SO_EXT:chromosome denotes chr.
T4206 21557-21561 PR_EXT:000000017 denotes Ifng
T4205 21542-21550 NCBITaxon:2 denotes bacteria
T4204 21528-21538 GO:0005618 denotes cell walls
T4203 21528-21532 CL_GO_EXT:cell denotes cell
T4202 21502-21506 CL_GO_EXT:cell denotes cell
T4201 21495-21506 CL:0000510 denotes Paneth cell
T4200 21469-21473 GO_SO_EXT:chromosome denotes chr.
T4199 21463-21467 GO_EXT:0003796 denotes Lyzs
T4198 21463-21467 PR_EXT:000010030 denotes Lyzs
T4197 21433-21441 GO:0042571 denotes antibody
T4196 21397-21401 GO_SO_EXT:chromosome denotes chr.
T4195 21365-21385 GO:0030154 denotes cell differentiation
T4194 21365-21369 CL_GO_EXT:cell denotes cell
T4193 21360-21369 CL:0000097 denotes mast cell
T4192 21328-21332 CL_GO_EXT:cell denotes cell
T4191 21323-21339 PR_EXT:000009345 denotes stem cell factor
T4190 21323-21332 CL:0000034 denotes stem cell
T4189 21285-21289 GO_SO_EXT:chromosome denotes chr.
T4188 21279-21283 PR_EXT:000009345 denotes Kitl
T4187 21265-21272 UBERON:0000479 denotes tissues
T4186 21256-21264 GO_PATO_EXT:inflammatory_process_or_quality denotes inflamed
T4185 21227-21237 CL:0000542 denotes lymphocyte
T4184 21193-21197 GO_SO_EXT:chromosome denotes chr.
T4183 21186-21191 PR_EXT:000001467 denotes Icam1
T4182 21169-21178 CHEBI:82761 denotes defensins
T4181 21143-21147 CL_GO_EXT:cell denotes cell
T4180 21136-21147 CL:0000510 denotes Paneth cell
T4179 21107-21111 GO_SO_EXT:chromosome denotes chr.
T4178 21101-21105 PR_EXT:000010489 denotes Mmp7
T4177 21083-21094 CL:0000542 denotes lymphocytes
T4176 21078-21081 PR_EXT:000001004 denotes CD4
T4175 21069-21077 GO_EXT:biological_recruitment denotes recruits
T4174 21050-21054 GO_SO_EXT:chromosome denotes chr.
T4173 21044-21048 PR_EXT:000010488 denotes Mmp3
T4172 21029-21033 GO_SO_EXT:chromosome denotes chr.
T4171 21023-21027 PR_EXT:000001156 denotes Tlr5
T4170 21014-21022 GO_EXT:0004872 denotes receptor
T4169 20983-20987 GO_SO_EXT:chromosome denotes chr.
T4168 20973-20979 PR_EXT:000007431 denotes Fcer1a
T4167 20957-20961 GO_SO_EXT:chromosome denotes chr.
T4166 20947-20953 PR_EXT:000007432 denotes Fcer1g
T4165 20931-20935 GO_SO_EXT:chromosome denotes chr.
T4164 20922-20927 PR_EXT:000001483 denotes Fcgr3
T4163 20910-20916 PR_EXT:000001481 denotes Fcgr2b
T4162 20903-20908 PR_EXT:000007442 denotes Fcrl3
T4161 20896-20901 SO_EXT:0000704 denotes genes
T4160 20869-20895 GO_EXT:0019763 denotes immunoglobulin Fc receptor
T4159 20869-20883 GO:0019814 denotes immunoglobulin
T4158 20843-20854 CL:0000542 denotes lymphocytes
T4157 20834-20842 GO_EXT:biological_recruitment denotes recruits
T4156 20824-20829 CL_GO_EXT:cell denotes cells
T4155 20819-20829 CL:0000097 denotes mast cells
T4154 20806-20815 GO:0010467 denotes expressed
T4153 20783-20787 GO_SO_EXT:chromosome denotes chr.
T4152 20777-20781 PR_EXT:000002140 denotes Xcl1
T4151 20772-20776 SO_EXT:0000704 denotes gene
T4150 20762-20771 GO_EXT:0008009 denotes chemokine
T4149 20731-20735 GO_SO_EXT:chromosome denotes chr.
T4148 20707-20713 PR_EXT:000001833 denotes slamf1
T4147 20678-20686 CHEBI_PR_EXT:protein denotes proteins
T4146 20665-20677 GO:0009986 denotes cell surface
T4145 20658-20669 CL:0000738 denotes immune cell
T4144 20658-20664 UBERON:0002405 denotes immune
T4143 20625-20632 UBERON:0000479 denotes tissues
T4142 20616-20624 GO_PATO_EXT:inflammatory_process_or_quality denotes inflamed
T4141 20593-20597 CL_GO_EXT:cell denotes cell
T4140 20586-20597 CL:0000738 denotes immune cell
T4139 20586-20592 UBERON:0002405 denotes immune
T4138 20548-20552 GO_SO_EXT:chromosome denotes chr.
T4137 20542-20546 PR_EXT:000001432 denotes Selp
T4136 20536-20540 PR_EXT:000001318 denotes Sell
T4135 20530-20534 PR_EXT:000001415 denotes Sele
T4134 20523-20528 SO_EXT:0000704 denotes genes
T4133 20514-20522 PR_EXT:selectin denotes selectin
T4132 20483-20487 CL_GO_EXT:cell denotes cell
T4131 20481-20498 GO:0042110 denotes T cell activation
T4130 20481-20487 CL:0000084 denotes T cell
T4129 20440-20444 GO_SO_EXT:chromosome denotes chr.
T4128 20422-20428 PR_EXT:000001949 denotes Tnfsf4
T4127 20398-20401 PR_EXT:tumor_necrosis_factor denotes TNF
T4126 20378-20385 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T4125 20330-20343 UBERON:0002405 denotes immune system
T4124 20309-20321 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammation
T4123 20291-20296 SO_EXT:0000704 denotes genes
T4122 20252-20264 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammation
T4121 20142-20154 GO_PATO_EXT:inflammatory_process_or_quality denotes Inflammation
T4120 20113-20119 SO_EXT:0001026 denotes Genome
T4119 20107-20112 NCBITaxon:10088 denotes Mouse
T4118 20083-20087 SO_EXT:0000704 denotes gene
T4117 20063-20067 GO_SO_EXT:chromosome denotes chr.
T4116 20056-20061 PR_EXT:000000782 denotes Kcnc2
T4115 20037-20041 GO_SO_EXT:chromosome denotes chr.
T4114 20030-20035 PR_EXT:000002005 denotes Kcnj5
T4113 20013-20017 GO_SO_EXT:chromosome denotes chr.
T4112 20005-20011 PR_EXT:000001979 denotes Kcnj10
T4111 19988-19992 GO_SO_EXT:chromosome denotes chr.
T4110 19981-19986 PR_EXT:000002004 denotes Kcnj9
T4109 19964-19979 GO:0042044 denotes fluid transport
T4108 19964-19969 UBERON:0006314 denotes fluid
T4107 19886-19891 SO_EXT:0000704 denotes genes
T4106 19868-19885 GO_EXT:0005267 denotes potassium channel
T4105 19868-19877 CHEBI_EXT:potassium denotes potassium
T4104 19800-19811 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes chromosomes
T4103 19779-19789 _FRAGMENT denotes regions of
T4102 19763-19767 PR_EXT:000001044 denotes CFTR
T4101 19707-19724 GO_EXT:0005254 denotes chloride channels
T4100 19707-19715 CHEBI:17996 denotes chloride
T4099 19667-19677 UBERON:0000160 denotes intestinal
T4098 19603-19610 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T4097 19547-19552 SO_EXT:0000704 denotes genes
T4096 19517-19524 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T4088 18635-18639 NCBITaxon:10088 denotes mice
T4087 18615-18619 GO_SO_EXT:chromosome denotes chr.
T4086 18605-18612 SO_EXT:0001023 denotes alleles
T4085 18580-18584 NCBITaxon:10088 denotes mice
T4084 18558-18562 GO_SO_EXT:chromosome denotes chr.
T4083 18545-18549 NCBITaxon:10088 denotes mice
T4082 18406-18416 SO_EXT:sequence_variation_entity_or_quality denotes variations
T4081 18378-18397 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes chromosomal regions
T4080 18336-18343 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T4079 18310-18314 NCBITaxon:10088 denotes mice
T4078 18197-18201 NCBITaxon:10088 denotes mice
T4077 18168-18172 GO_SO_EXT:chromosome denotes chr.
T4076 18151-18155 SO_EXT:0000704 denotes gene
T4075 18146-18150 PR_EXT:000001044 denotes Cftr
T4074 18089-18099 GO_SO_EXT:chromosome denotes chromosome
T4073 18078-18085 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T4072 18053-18057 NCBITaxon:10088 denotes mice
T4071 18028-18032 GO_SO_EXT:chromosome denotes chr.
T4070 17999-18006 SO_EXT:0001023 denotes alleles
T4069 17990-17994 NCBITaxon:10088 denotes mice
T4068 17963-17970 SO_EXT:0001023 denotes alleles
T4067 17919-17923 NCBITaxon:10088 denotes mice
T4066 17811-17815 NCBITaxon:10088 denotes mice
T4065 17751-17755 NCBITaxon:10088 denotes Mice
T4064 17736-17741 NCBITaxon:10088 denotes mouse
T4063 17704-17717 SO_EXT:polymorphism denotes polymorphisms
T4062 17693-17700 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T4061 17665-17668 CHEBI_SO_EXT:DNA denotes DNA
T4060 17660-17664 UBERON:0002415 denotes tail
T4059 17596-17603 SO_EXT:0000704 denotes genetic
T4058 17575-17582 SO_EXT:0001023 denotes alleles
T3427 16829-16833 GO:0016265 denotes died
T3426 16800-16804 NCBITaxon:10088 denotes mice
T3425 16713-16717 CHEBI_EXT:33290 denotes chow
T3424 16682-16686 GO:0016265 denotes died
T3423 16656-16660 NCBITaxon:10088 denotes mice
T3422 16618-16622 CHEBI_EXT:33290 denotes chow
T3421 16592-16596 NCBITaxon:10088 denotes mice
T3420 16582-16591 SO_EXT:wild_type_entity_or_quality denotes wild type
T3419 16534-16538 CHEBI_EXT:33290 denotes chow
T3418 16445-16449 NCBITaxon:10088 denotes Mice
T3417 16428-16432 CHEBI_EXT:33290 denotes chow
T3416 16377-16392 UBERON:0002108 denotes small intestine
T3415 16351-16356 UBERON:0000912 denotes mucus
T3414 16264-16268 NCBITaxon:10088 denotes mice
T3413 16240-16244 CHEBI_EXT:33290 denotes chow
T3412 16234-16239 NCBITaxon:10088 denotes mouse
T3411 16215-16218 GO:0007631 denotes fed
T3410 16206-16210 NCBITaxon:10088 denotes mice
T3409 16162-16172 UBERON:0000160 denotes intestinal
T3408 16134-16144 UBERON:0000160 denotes intestinal
T74 10-17 SO_EXT:0000704 denotes genetic
T75 51-61 UBERON:0000160 denotes intestinal
T76 62-74 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T77 88-93 NCBITaxon:10088 denotes mouse
T78 94-105 GO_SO_EXT:chromosome denotes chromosomes
T79 178-187 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T80 195-246 PR_EXT:000001044 denotes cystic fibrosis transmembrane conductance regulator
T81 211-236 GO:0055085 denotes transmembrane conductance
T82 216-224 GO:0016020 denotes membrane
T83 237-246 GO_EXT:regulator denotes regulator
T84 248-252 PR_EXT:000001044 denotes CFTR
T85 254-258 SO_EXT:0000704 denotes gene
T86 340-345 SO_EXT:0000704 denotes genes
T87 351-361 UBERON:0000160 denotes intestines
T88 365-369 PR_EXT:000001044 denotes Cftr
T89 380-384 NCBITaxon:10088 denotes mice
T90 389-393 NCBITaxon:10088 denotes mice
T91 395-399 PR_EXT:000001044 denotes Cftr
T92 445-450 UBERON:0000912 denotes mucus
T93 491-499 UBERON:0007109 denotes meconium
T94 517-527 UBERON:0000160 denotes intestinal
T95 594-601 SO_EXT:0000704 denotes genetic
T96 620-624 NCBITaxon:10088 denotes mice
T97 672-676 NCBITaxon:10088 denotes mice
T98 701-706 NCBITaxon:10088 denotes mouse
T99 707-711 CHEBI_EXT:33290 denotes chow
T100 718-730 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammation
T101 738-753 UBERON:0002108 denotes small intestine
T102 786-795 SO_EXT:wild_type_entity_or_quality denotes wild type
T103 856-866 UBERON:0000160 denotes intestinal
T104 906-910 NCBITaxon:10088 denotes mice
T105 922-929 SO_EXT:0000704 denotes genetic
T106 988-992 NCBITaxon:10088 denotes mice
T107 1058-1068 UBERON:0000160 denotes intestinal
T108 1086-1090 NCBITaxon:10088 denotes mice
T109 1159-1162 GO:0007631 denotes fed
T110 1167-1172 NCBITaxon:10088 denotes mouse
T111 1173-1177 CHEBI_EXT:33290 denotes chow
T112 1192-1202 UBERON:0000160 denotes intestinal
T113 1203-1215 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammation
T114 1244-1246 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T115 1255-1261 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T116 1262-1267 SO_EXT:0000704 denotes genes
T117 1286-1290 UBERON_EXT:body denotes body
T118 1321-1326 UBERON:0000912 denotes mucus
T119 1347-1364 UBERON:0001983 denotes intestinal crypts
T120 1413-1417 UBERON_EXT:body denotes body
T121 1431-1436 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T122 1539-1546 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T123 1606-1612 SO_EXT:0001026 denotes genome
T124 1622-1628 SO_EXT:0001023 denotes allele
T702 2661-2667 UBERON:0000479 denotes tissue
T703 2681-2691 UBERON:0001264 denotes pancreatic
T704 2747-2753 UBERON:0000062 denotes organs
T705 2768-2775 UBERON:0001005 denotes airways
T706 2780-2790 UBERON:0000160 denotes intestines
T707 2829-2833 PR_EXT:000001044 denotes CFTR
T708 2834-2843 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T709 2865-2869 PR_EXT:000001044 denotes CFTR
T710 2870-2877 CHEBI_PR_EXT:protein denotes protein
T711 2920-2925 SO_EXT:0000704 denotes genes
T712 3009-3019 UBERON:0001264 denotes pancreatic
T713 3056-3065 GO:0007586 denotes digestion
T714 3123-3127 PR_EXT:000001044 denotes CFTR
T715 3190-3194 UBERON:0000165 denotes oral
T716 3195-3201 CHEBI_GO_SO_EXT:enzyme denotes enzyme
T717 3252-3256 CHEBI_EXT:37527 denotes acid
T718 3268-3274 GO_EXT:0016298 denotes lipase
T719 3320-3329 GO:0007586 denotes digestion
T720 3348-3357 CHEBI_EXT:33284 denotes nutrients
T721 3405-3414 CHEBI_EXT:33284 denotes nutrients
T722 3478-3482 UBERON:0000165 denotes oral
T723 3483-3489 CHEBI_GO_SO_EXT:enzyme denotes enzyme
T724 3572-3577 UBERON:0000912 denotes mucus
T725 3601-3610 UBERON:0000160 denotes intestine
T726 3630-3642 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammation
T727 3659-3664 UBERON:0000912 denotes Mucus
T728 3699-3702 UBERON:0001555 denotes gut
T729 3733-3740 UBERON_EXT:baby_or_infant denotes infants
T730 3749-3757 UBERON:0007109 denotes meconium
T731 3773-3779 UBERON:0007023 denotes adults
T732 3795-3805 UBERON:0000160 denotes intestinal
T733 3862-3869 UBERON:0001005 denotes airways
T734 3888-3900 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammation
T735 3911-3921 UBERON:0000160 denotes intestines
T736 3983-3992 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T737 4000-4004 PR_EXT:000001044 denotes CFTR
T738 4005-4009 SO_EXT:0000704 denotes gene
T739 4068-4075 SO_EXT:0000704 denotes genetic
T740 4104-4109 NCBITaxon:9606 denotes human
T741 4123-4134 SO_EXT:0000704 denotes genetically
T742 4135-4142 SO_EXT:sequence_alteration_process denotes altered
T743 4143-4147 NCBITaxon:10088 denotes mice
T744 4177-4182 SO_EXT:0000704 denotes genes
T745 4268-4272 NCBITaxon:10088 denotes mice
T746 4286-4293 SO_EXT:0000704 denotes genetic
T747 4309-4318 _FRAGMENT denotes region on
T748 4325-4335 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes chromosome
T749 4319-4324 NCBITaxon:10088 denotes mouse
T750 4362-4372 UBERON:0000160 denotes intestinal
T751 4418-4425 CHEBI_EXT:calcium denotes calcium
T752 4426-4435 GO:0065007 denotes regulated
T753 4436-4438 CHEBI_EXT:chlorine denotes Cl
T754 4436-4446 GO_EXT:0005254 denotes Cl-channel
T755 4477-4481 PR_EXT:000001044 denotes CFTR
T756 4500-4506 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes Marker
T757 4507-4517 SO_EXT:0001024 denotes haplotypes
T758 4525-4540 SO_EXT:0005858 denotes syntenic region
T759 4534-4543 _FRAGMENT denotes region of
T760 4550-4560 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes chromosome
T761 4544-4549 NCBITaxon:9606 denotes human
T762 4658-4667 _FRAGMENT denotes region on
T763 4674-4678 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes chr.
T764 4668-4673 NCBITaxon:10088 denotes mouse
T765 4710-4714 UBERON:0002048 denotes lung
T766 4715-4727 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammation
T767 4743-4759 CL:0000842 denotes mononuclear cell
T768 4747-4754 GO:0005634 denotes nuclear
T769 4755-4759 CL_GO_EXT:cell denotes cell
T770 4760-4772 UBERON:0005169 denotes interstitial
T771 4805-4810 NCBITaxon:10088 denotes mouse
T772 4811-4818 UBERON:0001005 denotes airways
T773 4830-4842 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes loci on chr.
T774 4884-4890 UBERON:0001005 denotes airway
T775 4924-4928 NCBITaxon:10088 denotes mice
T776 5019-5023 NCBITaxon:10088 denotes mice
T777 5093-5103 UBERON:0001264 denotes pancreatic
T778 5127-5131 NCBITaxon:10088 denotes mice
T779 5176-5180 NCBITaxon:10088 denotes mice
T780 5232-5236 NCBITaxon:10088 denotes mice
T781 5316-5322 SO_EXT:0001026 denotes Genome
T782 5328-5334 SO_EXT:0001023 denotes allele
T783 5420-5430 UBERON:0000160 denotes intestinal
T784 5476-5481 SO_EXT:0000704 denotes genes
T785 5530-5540 UBERON:0000160 denotes intestinal
T1447 5583-5587 NCBITaxon:10088 denotes mice
T1448 5626-5630 UBERON_EXT:body denotes body
T1449 5643-5647 UBERON_EXT:body denotes Body
T1450 5670-5674 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T1451 5679-5685 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T1452 5686-5690 NCBITaxon:10088 denotes mice
T1453 5738-5744 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T1454 5749-5753 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T1455 5754-5758 NCBITaxon:10088 denotes mice
T1456 5786-5795 SO_EXT:wild_type_entity_or_quality denotes wild type
T1457 5796-5800 NCBITaxon:10088 denotes mice
T1458 5859-5865 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T1459 5869-5873 NCBITaxon:10088 denotes mice
T1460 5934-5943 SO_EXT:wild_type_entity_or_quality denotes wild type
T1461 5944-5948 NCBITaxon:10088 denotes mice
T1462 5991-5995 UBERON_EXT:body denotes body
T1463 6006-6012 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T1464 6016-6020 NCBITaxon:10088 denotes mice
T1465 6079-6083 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes Male
T1466 6087-6091 NCBITaxon:10088 denotes mice
T1467 6166-6175 SO_EXT:wild_type_entity_or_quality denotes wild type
T1468 6213-6217 NCBITaxon:10088 denotes mice
T1469 6281-6286 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T1470 6381-6390 SO_EXT:wild_type_entity_or_quality denotes wild type
T1471 6391-6395 NCBITaxon:10088 denotes mice
T1842 7077-7092 UBERON:0002108 denotes small intestine
T1843 7130-7137 SO_EXT:0000704 denotes genetic
T1845 7172-7184 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T1846 7185-7191 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T1847 7192-7197 SO_EXT:0000704 denotes genes
T1848 7223-7225 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T1849 7250-7254 SO_EXT:0000704 denotes gene
T1850 7250-7265 GO:0010467 denotes gene expression
T1851 7267-7277 GO:0010467 denotes Expression
T1852 7295-7300 SO_EXT:0000704 denotes genes
T1853 7317-7326 SO_EXT:wild_type_entity_or_quality denotes wild type
T1854 7334-7338 NCBITaxon:10088 denotes mice
T1855 7356-7363 SO_EXT:0000704 denotes genetic
T1856 7377-7386 CL:0000097 denotes Mast cell
T1857 7377-7397 PR_EXT:000010903 denotes Mast cell protease 2
T1858 7382-7386 CL_GO_EXT:cell denotes cell
T1859 7387-7395 GO_EXT:0008233 denotes protease
T1860 7399-7404 PR_EXT:000010903 denotes Mcpt2
T1861 7411-7417 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T1862 7421-7435 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T1863 7436-7446 CL:0000097 denotes mast cells
T1864 7441-7446 CL_GO_EXT:cell denotes cells
T1865 7456-7466 CL:0000097 denotes mast cells
T1866 7461-7466 CL_GO_EXT:cell denotes cells
T1867 7498-7503 NCBITaxon:10088 denotes mouse
T1868 7504-7513 UBERON:0000160 denotes intestine
T1869 7515-7522 CHEBI_SO_EXT:leucine denotes Leucine
T1870 7515-7543 PR_EXT:000009913 denotes Leucine-rich α2 glycoprotein
T1871 7531-7543 CHEBI:17089 denotes glycoprotein
T1872 7545-7549 PR_EXT:000009913 denotes Lrg1
T1873 7562-7568 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T1874 7572-7587 GO_RO_EXT:developmental_differentiation_process denotes differentiating
T1875 7588-7599 CL:0000775 denotes neutrophils
T1876 7638-7643 NCBITaxon:10088 denotes mouse
T1877 7644-7653 UBERON:0000160 denotes intestine
T1878 7664-7668 SO_EXT:0000704 denotes gene
T1879 7686-7693 CHEBI_SO_EXT:leucine denotes leucine
T1880 7686-7733 PR_EXT:000009913 denotes leucine-rich high endothelial cell glycoprotein
T1881 7704-7715 UBERON:0001986 denotes endothelial
T1882 7704-7720 CL:0000115 denotes endothelial cell
T1883 7716-7720 CL_GO_EXT:cell denotes cell
T1884 7721-7733 CHEBI:17089 denotes glycoprotein
T1885 7735-7739 PR_EXT:000009913 denotes Lrhg
T1886 7768-7774 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T1887 7783-7794 UBERON:0001986 denotes endothelial
T1888 7795-7802 UBERON:0001979 denotes venules
T1889 7832-7839 UBERON:0000479 denotes tissues
T1890 7847-7859 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammation
T1891 7869-7882 GO:0030097 denotes Hematopoietic
T1892 7869-7887 CL:0000988 denotes Hematopoietic cell
T1893 7883-7887 CL_GO_EXT:cell denotes cell
T1894 7888-7898 SO_EXT:0000673 denotes transcript
T1895 7920-7926 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T1896 7930-7935 UBERON:0000178 denotes blood
T1897 7930-7940 CL:0000081 denotes blood cell
T1898 7936-7940 CL_GO_EXT:cell denotes cell
T1899 7936-7954 GO:0008283 denotes cell proliferation
T1900 7963-7973 GO:0010467 denotes expression
T1901 8008-8013 NCBITaxon:10088 denotes mouse
T1902 8014-8029 UBERON:0002108 denotes small intestine
T1903 8031-8036 UBERON:0001977 denotes Serum
T1904 8031-8047 PR_EXT:000015919 denotes Serum amyloid A3
T1905 8037-8044 CHEBI:60425 denotes amyloid
T1906 8049-8053 PR_EXT:000015919 denotes SAA3
T1907 8067-8078 GO:0006953 denotes acute phase
T1908 8079-8083 SO_EXT:0000704 denotes gene
T1909 8092-8102 GO:0010467 denotes expression
T1910 8106-8112 GO_UBERON_EXT:villus denotes villus
T1911 8106-8123 UBERON:0013636 denotes villus epithelial
T1912 8113-8129 CL:0000066 denotes epithelial cells
T1913 8124-8129 CL_GO_EXT:cell denotes cells
T1914 8156-8165 UBERON:0000160 denotes intestine
T1915 8167-8201 PR_EXT:000015394 denotes Suppressor of cytokine signaling 3
T1916 8181-8189 GO_EXT:0005125 denotes cytokine
T1917 8181-8199 GO:0019221 denotes cytokine signaling
T1918 8203-8208 PR_EXT:000015394 denotes SOCS3
T1919 8227-8239 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T1920 8240-8244 SO_EXT:0000704 denotes gene
T1921 8269-8272 PR_EXT:000025748 denotes JAK
T1922 8269-8285 GO:0007259 denotes JAK-STAT pathway
T1923 8273-8277 PR_EXT:000001933 denotes STAT
T1924 8294-8304 GO:0010467 denotes expression
T1925 8331-8340 UBERON:0000160 denotes intestine
T1926 8342-8348 PR_EXT:000006534 denotes Muclin
T1927 8364-8369 PR_EXT:000006534 denotes dmbt1
T1928 8377-8387 GO:0010467 denotes expression
T1929 8391-8402 GO_EXT:positive_regulation denotes upregulated
T1930 8416-8425 UBERON:0000160 denotes intestine
T1931 8435-8439 CL_GO_EXT:cell denotes cell
T1932 8435-8447 GO:0009986 denotes cell surface
T1933 8448-8460 CHEBI:17089 denotes glycoprotein
T1934 8481-8491 UBERON:0000483 denotes epithelial
T1935 8503-8511 CHEBI:36357 denotes molecule
T1936 8555-8560 PR_EXT:000010903 denotes Mcpt2
T1937 8581-8585 NCBITaxon:10088 denotes mice
T1938 8634-8643 SO_EXT:wild_type_entity_or_quality denotes wild type
T1939 8710-8715 PR_EXT:000010903 denotes Mcpt2
T1940 8716-8726 GO:0010467 denotes expression
T1941 8742-8751 SO_EXT:wild_type_entity_or_quality denotes wild type
T1942 8787-8791 PR_EXT:000009913 denotes Lrg1
T1943 8792-8796 PR_EXT:000009913 denotes Lrhg
T1944 8797-8807 GO:0010467 denotes expression
T1945 8846-8850 NCBITaxon:10088 denotes mice
T1946 8884-8893 SO_EXT:wild_type_entity_or_quality denotes wild type
T1947 8950-8959 SO_EXT:wild_type_entity_or_quality denotes wild type
T1948 8995-8999 PR_EXT:000015919 denotes SAA3
T1949 9000-9004 CHEBI_SO_EXT:mRNA denotes mRNA
T1950 9040-9044 NCBITaxon:10088 denotes mice
T1951 9115-9124 SO_EXT:wild_type_entity_or_quality denotes wild type
T1952 9160-9165 PR_EXT:000015394 denotes SOCS3
T1953 9203-9207 NCBITaxon:10088 denotes mice
T1954 9241-9250 SO_EXT:wild_type_entity_or_quality denotes wild type
T1955 9311-9320 SO_EXT:wild_type_entity_or_quality denotes wild type
T1956 9372-9378 PR_EXT:000006534 denotes Muclin
T1957 9386-9395 GO:0010467 denotes expressed
T1958 9420-9429 UBERON:0000160 denotes intestine
T1959 9484-9494 GO:0010467 denotes expression
T1960 9507-9511 NCBITaxon:10088 denotes mice
T1961 9549-9558 SO_EXT:wild_type_entity_or_quality denotes wild type
T1962 9593-9602 GO:0010467 denotes expressed
T1963 9627-9631 NCBITaxon:10088 denotes mice
T1964 9644-9653 SO_EXT:wild_type_entity_or_quality denotes wild type
T1965 9690-9700 GO:0010467 denotes expression
T1966 9744-9753 SO_EXT:wild_type_entity_or_quality denotes wild type
T1967 10527-10531 UBERON_EXT:body denotes body
T1968 10544-10548 SO_EXT:0000704 denotes gene
T1969 10544-10559 GO:0010467 denotes gene expression
T1970 10637-10644 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T1971 10649-10654 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T1972 10683-10690 NCBITaxon:33208 denotes animals
T1973 10723-10733 GO:0071514 denotes imprinting
T2718 10789-10794 UBERON:0000912 denotes mucus
T2719 10860-10865 NCBITaxon:10088 denotes mouse
T2720 10866-10881 UBERON:0002108 denotes small intestine
T2721 10905-10910 UBERON:0000912 denotes mucus
T2722 10914-10931 UBERON:0001983 denotes intestinal crypts
T2723 10961-10967 GO_EXT:fatality_or_lethality denotes lethal
T2724 10996-11001 GO:0016265 denotes death
T2725 11011-11015 NCBITaxon:10088 denotes mice
T2726 11036-11040 CHEBI_EXT:33290 denotes chow
T2727 11058-11071 CHEBI:29149 denotes periodic acid
T2728 11135-11150 UBERON:0002108 denotes small intestine
T2729 11151-11158 UBERON:0000479 denotes tissues
T2730 11178-11187 SO_EXT:wild_type_entity_or_quality denotes wild type
T2731 11188-11203 UBERON:0002108 denotes small intestine
T2732 11233-11240 SO_EXT:0000704 denotes genetic
T2733 11271-11288 UBERON:0001983 denotes intestinal crypts
T2734 11347-11352 GO_UBERON_EXT:lumen denotes lumen
T2735 11405-11411 GO_UBERON_EXT:villus denotes villus
T2736 11405-11422 UBERON:0013636 denotes villus epithelium
T2737 11451-11463 CL:0000160 denotes goblet cells
T2738 11458-11463 CL_GO_EXT:cell denotes cells
T2739 11493-11502 SO_EXT:wild_type_entity_or_quality denotes wild type
T2740 11503-11510 UBERON:0000479 denotes tissues
T2741 11529-11538 UBERON:0000160 denotes intestine
T2742 11545-11549 NCBITaxon:10088 denotes mice
T2743 11560-11567 SO_EXT:0000704 denotes genetic
T2744 11605-11611 UBERON:0001983 denotes crypts
T2745 11637-11642 UBERON:0000912 denotes mucus
T2746 11657-11661 NCBITaxon:10088 denotes mice
T2747 11695-11700 UBERON:0000912 denotes mucus
T2748 11722-11726 NCBITaxon:10088 denotes mice
T2749 11775-11780 UBERON:0000912 denotes mucus
T2750 11787-11791 NCBITaxon:10088 denotes mice
T2751 11834-11839 NCBITaxon:10088 denotes mouse
T2752 11843-11848 NCBITaxon:10088 denotes mouse
T2753 11858-11862 NCBITaxon:10088 denotes mice
T2754 11890-11896 UBERON:0001983 denotes crypts
T2755 11913-11918 UBERON:0000912 denotes mucus
T2756 11927-11932 UBERON:0001983 denotes crypt
T2757 11933-11939 GO_UBERON_EXT:lumen denotes lumina
T2758 11971-11975 NCBITaxon:10088 denotes mice
T2759 11991-11996 UBERON:0000912 denotes mucus
T2760 12004-12010 UBERON:0001983 denotes crypts
T2761 12048-12053 UBERON:0000912 denotes mucus
T2762 12096-12100 NCBITaxon:10088 denotes mice
T2763 12176-12181 UBERON:0000912 denotes mucus
T2764 12196-12201 UBERON:0000912 denotes mucus
T2765 12235-12240 UBERON:0000912 denotes mucus
T2766 12278-12282 NCBITaxon:10088 denotes mice
T2767 12316-12321 UBERON:0001983 denotes crypt
T2768 12340-12345 UBERON:0000912 denotes mucus
T2769 12374-12378 NCBITaxon:10088 denotes mice
T2770 13472-13479 SO_EXT:0000704 denotes genetic
T2771 13540-13549 GO_EXT:secretion_entity_or_process denotes secretion
T2772 13570-13575 UBERON:0000912 denotes mucus
T2773 13586-13601 UBERON:0002108 denotes small intestine
T2774 13674-13678 SO_EXT:0000704 denotes gene
T2775 13674-13689 GO:0010467 denotes gene expression
T2776 13704-13706 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T2777 13731-13735 CHEBI_SO_EXT:mRNA denotes mRNA
T2778 13736-13746 GO:0010467 denotes expression
T2779 13754-13764 UBERON:0000160 denotes intestinal
T2780 13765-13776 CL:0000160 denotes goblet cell
T2781 13772-13776 CL_GO_EXT:cell denotes cell
T2782 13783-13787 SO_EXT:0000704 denotes gene
T2783 13789-13793 PR_EXT:000010764 denotes Muc2
T2784 13798-13807 SO_EXT:wild_type_entity_or_quality denotes wild type
T2785 13808-13817 UBERON:0000160 denotes intestine
T2786 13822-13826 NCBITaxon:10088 denotes mice
T2787 13847-13853 SO_EXT:sequence_copy_entity denotes copies
T2788 13857-13861 PR_EXT:000010764 denotes Muc2
T2789 13862-13867 GO_PR_EXT:glyceraldehyde_3_phosphate_dehydrogenase denotes GAPDH
T2790 13948-13952 NCBITaxon:10088 denotes mice
T2791 13994-14000 SO_EXT:sequence_copy_entity denotes copies
T2792 14004-14008 PR_EXT:000010764 denotes Muc2
T2793 14009-14013 CHEBI_SO_EXT:mRNA denotes mRNA
T2794 14018-14023 GO_PR_EXT:glyceraldehyde_3_phosphate_dehydrogenase denotes GAPDH
T2795 14124-14129 UBERON:0000912 denotes mucus
T2796 14180-14184 PR_EXT:000010764 denotes Muc2
T2797 14185-14189 CHEBI_SO_EXT:mRNA denotes mRNA
T2798 14200-14215 UBERON:0002108 denotes small intestine
T2799 14337-14342 UBERON:0000912 denotes mucus
T2800 14390-14394 SO_EXT:0000704 denotes gene
T2801 14390-14405 GO:0010467 denotes gene expression
T6570 6427-6434 SO_EXT:0000704 denotes genetic
T6571 6449-6453 UBERON_EXT:body denotes body
T6572 6468-6472 NCBITaxon:10088 denotes mice
T6573 6478-6484 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes Female
T6574 6493-6497 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T6575 6498-6502 NCBITaxon:10088 denotes mice
T6576 6738-6747 SO_EXT:wild_type_entity_or_quality denotes wild type
T6577 6761-6768 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T6578 6773-6782 SO_EXT:wild_type_entity_or_quality denotes wild type
T6579 6809-6816 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T6580 6821-6830 SO_EXT:wild_type_entity_or_quality denotes wild type
T6581 6844-6849 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T6582 6858-6867 SO_EXT:wild_type_entity_or_quality denotes wild type
T6583 6894-6899 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T6728 9785-9792 SO_EXT:0000704 denotes genetic
T6729 9807-9819 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T6730 9820-9824 SO_EXT:0000704 denotes gene
T6731 9820-9835 GO:0010467 denotes gene expression
T6732 9842-9847 NCBITaxon:10088 denotes mouse
T6733 9848-9863 UBERON:0002108 denotes small intestine
T6734 9865-9868 CHEBI_SO_EXT:RNA denotes RNA
T6735 9869-9879 GO:0010467 denotes expression
T6736 9929-9931 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T6737 9942-9946 SO_EXT:0000704 denotes gene
T6738 9956-9963 SO_EXT:0000112 denotes primers
T6739 9996-10001 GO_PR_EXT:glyceraldehyde_3_phosphate_dehydrogenase denotes GAPDH
T6740 10002-10006 CHEBI_SO_EXT:mRNA denotes mRNA
T6741 10036-10045 SO_EXT:wild_type_entity_or_quality denotes wild type
T6742 10053-10057 NCBITaxon:10088 denotes mice
T6743 10091-10100 SO_EXT:wild_type_entity_or_quality denotes wild type
T6744 10296-10301 SO_EXT:0000704 denotes genes
T6745 10313-10322 SO_EXT:wild_type_entity_or_quality denotes wild type
T6746 10326-10330 NCBITaxon:10088 denotes mice
T6747 10334-10343 SO_EXT:wild_type_entity_or_quality denotes wild type
T6748 10368-10372 NCBITaxon:10088 denotes mice
T6749 10400-10409 SO_EXT:wild_type_entity_or_quality denotes wild type
T6750 10484-10488 SO_EXT:0000704 denotes gene
T6930 12442-12457 UBERON:0002108 denotes small intestine
T6931 12461-12470 SO_EXT:wild_type_entity_or_quality denotes wild type
T6932 12478-12482 NCBITaxon:10088 denotes mice
T6933 12500-12507 SO_EXT:0000704 denotes genetic
T6934 12521-12527 UBERON:0000479 denotes Tissue
T6935 12639-12654 UBERON:0002108 denotes small intestine
T6936 12659-12668 SO_EXT:wild_type_entity_or_quality denotes Wild type
T6937 12724-12733 SO_EXT:wild_type_entity_or_quality denotes Wild type
T6938 12807-12816 SO_EXT:wild_type_entity_or_quality denotes wild type
T6939 12817-12823 UBERON:0000479 denotes tissue
T6940 12851-12857 UBERON:0001983 denotes crypts
T6941 12884-12890 GO_UBERON_EXT:lumen denotes lumina
T6942 12915-12921 UBERON:0000479 denotes tissue
T6943 12948-12953 UBERON:0001983 denotes crypt
T6944 12954-12960 GO_UBERON_EXT:lumen denotes lumina
T6945 13010-13015 UBERON:0000912 denotes mucus
T6946 13037-13041 NCBITaxon:10088 denotes mice
T6947 13071-13077 UBERON:0001983 denotes crypts
T6948 13112-13121 SO_EXT:wild_type_entity_or_quality denotes wild type
T6949 13135-13141 UBERON:0001983 denotes crypts
T6950 13181-13185 NCBITaxon:10088 denotes mice
T6951 13230-13236 UBERON:0001983 denotes crypts
T6952 13267-13272 UBERON:0001983 denotes crypt
T6953 13286-13291 UBERON:0000912 denotes mucus
T6954 13326-13330 NCBITaxon:10088 denotes mice
T4094 19496-19497 NCBITaxon:10088 denotes c
T4093 19495-19496 SO_EXT:0001023 denotes e
T4092 18709-18716 SO_EXT:0001023 denotes alleles
T4091 18684-18688 NCBITaxon:10088 denotes mice
T7425 18759-18763 NCBITaxon:10088 denotes mice
T7424 18728-18734 SO_EXT:0001026 denotes Genome
T7402 15671-15675 PR_EXT:000001044 denotes Cftr
T7401 15662-15670 GO_EXT:breeding denotes breeding
T7400 15642-15646 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T7399 15629-15638 SO_EXT:genotype_or_entity_with_genotype denotes genotypes
T7398 15624-15628 PR_EXT:000001044 denotes Cftr
T6383 26883-26898 UBERON:0002108 denotes small intestine
T7370 15129-15133 PR_EXT:000001044 denotes Cftr
T7371 15134-15143 SO_EXT:genotype_or_entity_with_genotype denotes genotypes
T7372 15147-15153 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T7373 15169-15177 GO_EXT:breeding denotes breeding
T7374 15178-15182 PR_EXT:000001044 denotes Cftr
T3407 16126-16130 NCBITaxon:10088 denotes mice
T3406 16114-16119 GO:0016265 denotes death
T3393 14411-14415 NCBITaxon:10088 denotes mice
T3394 14514-14518 PR_EXT:000001044 denotes Cftr
T3395 14519-14523 SO_EXT:sequence_nullness denotes null
T3396 14524-14528 NCBITaxon:10088 denotes mice
T3397 14632-14640 OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process denotes genetics
T3398 14702-14706 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T3399 14707-14711 NCBITaxon:10088 denotes mice
T3400 14788-14797 SO_EXT:genotype_or_entity_with_genotype denotes genotypes
T3401 14801-14807 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T3402 14884-14888 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T3403 14889-14893 NCBITaxon:10088 denotes mice
T3404 14991-14996 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T3405 15098-15102 NCBITaxon:10088 denotes mice
T125 1727-1731 GO_SO_EXT:chromosome denotes chr.
T126 1745-1751 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T127 1768-1772 GO_SO_EXT:chromosome denotes chr.
T128 1786-1792 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T129 1813-1817 GO_SO_EXT:chromosome denotes chr.
T130 1833-1839 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T131 1935-1947 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T132 1968-1973 NCBITaxon:10088 denotes mouse
T133 1974-1989 UBERON:0002108 denotes small intestine
T134 1994-2000 NCBITaxon:33208 denotes animal
T135 2029-2042 SO_EXT:polymorphism denotes polymorphisms
T136 2055-2060 SO_EXT:0000704 denotes genes
T137 2125-2132 SO_EXT:0000704 denotes genetic
T138 2153-2163 UBERON:0000160 denotes intestinal
T2716 10739-10743 NCBITaxon:10088 denotes mice
T2717 10778-10788 UBERON:0000160 denotes intestinal
T1836 6905-6909 NCBITaxon:10088 denotes mice
T1837 6947-6957 GO:0010467 denotes expression
T1838 6961-6973 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T1839 6974-6981 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T1840 7011-7015 NCBITaxon:10088 denotes mice
T1841 7057-7069 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammation
T1844 7158-7168 GO:0010467 denotes expression
T678 2221-2230 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T679 2238-2289 PR_EXT:000001044 denotes cystic fibrosis transmembrane conductance regulator
T680 2254-2279 GO:0055085 denotes transmembrane conductance
T681 2259-2267 GO:0016020 denotes membrane
T682 2280-2289 GO_EXT:regulator denotes regulator
T683 2291-2295 PR_EXT:000001044 denotes CFTR
T684 2297-2301 SO_EXT:0000704 denotes gene
T685 2317-2326 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T686 2368-2372 PR_EXT:000001044 denotes CFTR
T687 2373-2380 CHEBI_PR_EXT:protein denotes protein
T688 2411-2421 UBERON:0000483 denotes epithelial
T689 2422-2438 GO:0006821 denotes transport of Cl-
T690 2422-2434 _FRAGMENT denotes transport of
T691 2443-2448 GO:0015701 denotes HCO3-
T692 2435-2438 CHEBI:17996 denotes Cl-
T693 2443-2448 CHEBI:17544 denotes HCO3-
T694 2476-2486 UBERON:0001264 denotes pancreatic
T695 2500-2505 NCBITaxon:9606 denotes human
T696 2556-2560 PR_EXT:000001044 denotes CFTR
T697 2589-2598 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T698 2608-2612 PR_EXT:000001044 denotes CFTR
T699 2633-2647 _FRAGMENT denotes destruction of
T700 2661-2667 GO:0016271 denotes tissue
T701 2652-2660 UBERON:0002330 denotes exocrine
T4095 19506-19507 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes s
T4090 18666-18670 GO_SO_EXT:chromosome denotes chr.
T4089 18652-18659 SO_EXT:0001023 denotes alleles
R374 T691 T690 _lexicallyChainedTo HCO3-,transport of
R375 T700 T699 _lexicallyChainedTo tissue,destruction of
R376 T748 T747 _lexicallyChainedTo chromosome,region on
R377 T760 T759 _lexicallyChainedTo chromosome,region of
R378 T763 T762 _lexicallyChainedTo chr.,region on
R2532 T4104 T4103 _lexicallyChainedTo chromosomes,regions of
R2533 T4212 T4211 _lexicallyChainedTo IL-10 interleukin family,member of
R2534 T4252 T4251 _lexicallyChainedTo cells,differentiation of
R3605 T5462 T5461 _lexicallyChainedTo differentiation,cell
R4154 T6250 T6249 _lexicallyChainedTo primers,forward
R4155 T6252 T6251 _lexicallyChainedTo primers,reverse

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T7397 15671-15675 PR:000001044 denotes Cftr
T7396 15624-15628 PR:000001044 denotes Cftr
T6460 27495-27499 NCBITaxon:10088 denotes mice
T6459 27485-27489 PR:000001044 denotes Cftr
T6458 27207-27222 GO:0010467 denotes Gene expression
T6457 27207-27211 SO:0000704 denotes Gene
T6382 27146-27159 CHEBI:29149 denotes periodic acid
T6381 27000-27007 UBERON:0000479 denotes tissues
T6380 26883-26898 UBERON:0002108 denotes small intestine
T7211 17431-17435 GO:0016265 denotes died
T7210 17400-17404 NCBITaxon:10088 denotes mice
T7209 17358-17362 NCBITaxon:10088 denotes mice
T7208 17344-17349 GO:0016265 denotes death
T7207 17279-17284 GO:0016265 denotes death
T7206 17224-17228 NCBITaxon:10088 denotes mice
T7205 17164-17169 GO:0016265 denotes death
T7204 17118-17122 NCBITaxon:10088 denotes mice
T7203 17076-17082 GO:0016265 denotes Deaths
T7202 17041-17045 CHEBI:33290 denotes chow
T7201 17035-17040 NCBITaxon:10088 denotes mouse
T7200 17016-17019 GO:0007631 denotes fed
T7199 16919-16923 NCBITaxon:10088 denotes Mice
T7198 16913-16917 CHEBI:33290 denotes chow
T7197 16889-16894 NCBITaxon:10088 denotes mouse
T7196 16864-16871 SO:0000704 denotes genetic
T6231 26859-26866 SO:0000132 denotes primers
T6230 26816-26823 _FRAGMENT denotes reverse
T6229 26859-26866 SO:0000121 denotes primers
T6228 26769-26776 _FRAGMENT denotes forward
T6227 26735-26739 PR:000010764 denotes Muc2
T6226 26717-26727 UBERON:0000160 denotes intestinal
T6225 26693-26703 GO:0010467 denotes Expression
T6224 26671-26686 UBERON:0002108 denotes small intestine
T6223 26665-26670 NCBITaxon:10088 denotes mouse
T6222 26635-26639 SO:0000704 denotes gene
T6221 26603-26613 GO:0010467 denotes expression
T6220 26548-26555 SO:0000112 denotes primers
T6219 26511-26516 SO:0000704 denotes genes
T6218 26488-26498 GO:0010467 denotes expression
T6217 26391-26406 UBERON:0002108 denotes small intestine
T6216 26335-26350 GO:0010467 denotes gene expression
T6215 26335-26339 SO:0000704 denotes gene
T6083 26308-26317 GO:0030849 denotes autosomes
T6082 26140-26147 SO:0001023 denotes alleles
T6081 26101-26108 SO:0000112 denotes primers
T6080 26068-26072 SO:0000207 denotes SSLP
T6079 26031-26066 SO:0000207 denotes simple sequence length polymorphism
T6078 25986-25990 UBERON:0002415 denotes tail
T6077 25980-25985 NCBITaxon:10088 denotes mouse
T6076 25964-25968 NCBITaxon:10088 denotes mice
T6075 25810-25816 SO:0001026 denotes Genome
T6074 25773-25780 SO:0000704 denotes Genetic
T5446 24124-24134 UBERON:0000160 denotes intestinal
T5445 24101-24106 SO:0000704 denotes genes
T5444 24078-24088 GO:0010467 denotes expression
T5443 23875-23885 CL:0000775 denotes neutrophil
T5442 23861-23870 CL:0000097 denotes mast cell
T5441 23807-23812 SO:0000704 denotes genes
T5440 23786-23791 UBERON:0000912 denotes mucus
T5439 23770-23782 CL:0000738 denotes immune cells
T5438 23770-23776 UBERON:0002405 denotes immune
T5437 23725-23740 UBERON:0002108 denotes small intestine
T5436 23553-23560 SO:0001023 denotes alleles
T5435 23512-23516 NCBITaxon:10088 denotes mice
T5653 25619-25623 NCBITaxon:10088 denotes Mice
T5652 25582-25586 NCBITaxon:10088 denotes mice
T5651 25526-25530 CHEBI:33290 denotes chow
T5650 25466-25470 NCBITaxon:10088 denotes Mice
T5649 25413-25417 CHEBI:33290 denotes chow
T5648 25407-25412 NCBITaxon:10088 denotes mouse
T5647 25374-25378 NCBITaxon:10088 denotes mice
T5646 25275-25279 NCBITaxon:10088 denotes mice
T5645 25234-25244 UBERON:0000160 denotes intestinal
T5644 25133-25137 NCBITaxon:10088 denotes mice
T5643 25033-25037 NCBITaxon:10088 denotes Mice
T5642 25021-25025 PR:000001044 denotes Cftr
T5641 24999-25003 PR:000001044 denotes Cftr
T5640 24985-24989 PR:000001044 denotes Cftr
T5639 24958-24962 PR:000001044 denotes Cftr
T5638 24939-24946 SO:0001023 denotes alleles
T5637 24907-24911 NCBITaxon:10088 denotes mice
T5636 24882-24886 NCBITaxon:10088 denotes mice
T5635 24829-24833 NCBITaxon:10088 denotes mice
T5634 24787-24793 SO:0001026 denotes genome
T5633 24749-24753 NCBITaxon:10088 denotes mice
T5632 24739-24743 PR:000001044 denotes Cftr
T5631 24691-24695 NCBITaxon:10088 denotes mice
T5630 24579-24583 SO:0000704 denotes gene
T5629 24530-24534 NCBITaxon:10088 denotes Mice
T5628 24435-24439 NCBITaxon:10088 denotes mice
T5627 24222-24229 SO:0000704 denotes genetic
T5626 24200-24204 NCBITaxon:10088 denotes mice
T5625 24190-24194 PR:000001044 denotes Cftr
T5624 24168-24175 NCBITaxon:33208 denotes Animals
T4036 22736-22747 CL:0000775 denotes neutrophils
T4035 22714-22719 PR:000010903 denotes Mcpt2
T4034 22700-22710 GO:0010467 denotes expression
T4033 22643-22653 CL:0000097 denotes mast cells
T4032 22591-22595 NCBITaxon:10088 denotes mice
T4031 22572-22582 CL:0000097 denotes mast cells
T4030 22577-22582 GO:0030154 denotes cells
T4029 22553-22571 _FRAGMENT denotes differentiation of
T4028 22533-22537 SO:0000704 denotes gene
T4027 22528-22532 PR:000009345 denotes Kitl
T4026 22469-22474 SO:0000704 denotes genes
T4025 22452-22463 CL:0000775 denotes neutrophils
T4024 22437-22447 CL:0000097 denotes mast cells
T4023 22402-22408 UBERON:0002405 denotes immune
T4022 22390-22417 GO:0045087 denotes innate type immune response
T4021 22346-22356 UBERON:0000160 denotes intestinal
T4020 22340-22345 NCBITaxon:10088 denotes mouse
T4019 22272-22277 SO:0000704 denotes genes
T4018 22199-22204 GO:0007567 denotes natal
T4017 21954-21959 NCBITaxon:10088 denotes mouse
T4016 21911-21914 SO:0000771 denotes QTL
T4015 21823-21855 GO:0035556 denotes intracellular signaling pathways
T4014 21823-21836 GO:0005622 denotes intracellular
T4013 21767-21772 SO:0000704 denotes genes
T4012 21755-21760 PR:000002088 denotes Stat2
T4011 21716-21740 PR:000001335 denotes IL-10 interleukin family
T4010 21684-21693 _FRAGMENT denotes member of
T4009 21660-21664 PR:000001383 denotes Il22
T4008 21557-21561 PR:000000017 denotes Ifng
T4007 21542-21550 NCBITaxon:2 denotes bacteria
T4006 21528-21538 GO:0005618 denotes cell walls
T4005 21495-21506 CL:0000510 denotes Paneth cell
T4004 21463-21467 PR:000010030 denotes Lyzs
T4003 21433-21441 GO:0042571 denotes antibody
T4002 21365-21385 GO:0030154 denotes cell differentiation
T4001 21360-21369 CL:0000097 denotes mast cell
T4000 21323-21339 PR:000009345 denotes stem cell factor
T3999 21323-21332 CL:0000034 denotes stem cell
T3998 21279-21283 PR:000009345 denotes Kitl
T3997 21265-21272 UBERON:0000479 denotes tissues
T3996 21227-21237 CL:0000542 denotes lymphocyte
T3995 21186-21191 PR:000001467 denotes Icam1
T3994 21169-21178 CHEBI:82761 denotes defensins
T3993 21136-21147 CL:0000510 denotes Paneth cell
T3992 21101-21105 PR:000010489 denotes Mmp7
T3991 21083-21094 CL:0000542 denotes lymphocytes
T3990 21078-21081 PR:000001004 denotes CD4
T3989 21044-21048 PR:000010488 denotes Mmp3
T3988 21023-21027 PR:000001156 denotes Tlr5
T3987 20973-20979 PR:000007431 denotes Fcer1a
T3986 20947-20953 PR:000007432 denotes Fcer1g
T3985 20922-20927 PR:000001483 denotes Fcgr3
T3984 20910-20916 PR:000001481 denotes Fcgr2b
T3983 20903-20908 PR:000007442 denotes Fcrl3
T3982 20896-20901 SO:0000704 denotes genes
T3981 20869-20883 GO:0019814 denotes immunoglobulin
T3980 20843-20854 CL:0000542 denotes lymphocytes
T3979 20819-20829 CL:0000097 denotes mast cells
T3978 20806-20815 GO:0010467 denotes expressed
T3977 20777-20781 PR:000002140 denotes Xcl1
T3976 20772-20776 SO:0000704 denotes gene
T3975 20707-20713 PR:000001833 denotes slamf1
T3974 20665-20677 GO:0009986 denotes cell surface
T3973 20658-20669 CL:0000738 denotes immune cell
T3972 20658-20664 UBERON:0002405 denotes immune
T3971 20625-20632 UBERON:0000479 denotes tissues
T3970 20586-20597 CL:0000738 denotes immune cell
T3969 20586-20592 UBERON:0002405 denotes immune
T3968 20542-20546 PR:000001432 denotes Selp
T3967 20536-20540 PR:000001318 denotes Sell
T3966 20530-20534 PR:000001415 denotes Sele
T3965 20523-20528 SO:0000704 denotes genes
T3964 20481-20498 GO:0042110 denotes T cell activation
T3963 20481-20487 CL:0000084 denotes T cell
T3962 20422-20428 PR:000001949 denotes Tnfsf4
T3961 20330-20343 UBERON:0002405 denotes immune system
T3960 20291-20296 SO:0000704 denotes genes
T3959 20113-20119 SO:0001026 denotes Genome
T3958 20107-20112 NCBITaxon:10088 denotes Mouse
T3957 20083-20087 SO:0000704 denotes gene
T3956 20056-20061 PR:000000782 denotes Kcnc2
T3955 20030-20035 PR:000002005 denotes Kcnj5
T3954 20005-20011 PR:000001979 denotes Kcnj10
T3953 19981-19986 PR:000002004 denotes Kcnj9
T3952 19964-19979 GO:0042044 denotes fluid transport
T3951 19964-19969 UBERON:0006314 denotes fluid
T3950 19886-19891 SO:0000704 denotes genes
T3949 19763-19767 PR:000001044 denotes CFTR
T3948 19707-19715 CHEBI:17996 denotes chloride
T3947 19667-19677 UBERON:0000160 denotes intestinal
T3946 19547-19552 SO:0000704 denotes genes
T3945 19496-19497 NCBITaxon:10088 denotes c
T3944 19495-19496 SO:0001023 denotes e
T3943 18709-18716 SO:0001023 denotes alleles
T3942 18684-18688 NCBITaxon:10088 denotes mice
T3941 18652-18659 SO:0001023 denotes alleles
T3940 18635-18639 NCBITaxon:10088 denotes mice
T3939 18605-18612 SO:0001023 denotes alleles
T3938 18580-18584 NCBITaxon:10088 denotes mice
T3937 18545-18549 NCBITaxon:10088 denotes mice
T3936 18310-18314 NCBITaxon:10088 denotes mice
T3935 18197-18201 NCBITaxon:10088 denotes mice
T3934 18151-18155 SO:0000704 denotes gene
T3933 18146-18150 PR:000001044 denotes Cftr
T3932 18053-18057 NCBITaxon:10088 denotes mice
T3931 17999-18006 SO:0001023 denotes alleles
T3930 17990-17994 NCBITaxon:10088 denotes mice
T3929 17963-17970 SO:0001023 denotes alleles
T3928 17919-17923 NCBITaxon:10088 denotes mice
T3927 17811-17815 NCBITaxon:10088 denotes mice
T3926 17751-17755 NCBITaxon:10088 denotes Mice
T3925 17736-17741 NCBITaxon:10088 denotes mouse
T3924 17660-17664 UBERON:0002415 denotes tail
T3923 17596-17603 SO:0000704 denotes genetic
T3922 17575-17582 SO:0001023 denotes alleles
T4057 23402-23407 UBERON:0000912 denotes mucus
T4056 23348-23362 CHEBI:26333 denotes prostaglandins
T4055 23326-23335 CHEBI:18295 denotes histamine
T4054 23313-23324 CL:0000775 denotes neutrophils
T4053 23298-23308 CL:0000097 denotes mast cells
T4052 23276-23285 CHEBI:36357 denotes molecules
T4051 23267-23275 CHEBI:35224 denotes effector
T4050 23227-23232 UBERON:0000912 denotes mucus
T4049 23165-23171 UBERON:0000062 denotes organs
T4048 23120-23126 CHEBI:37527 denotes acidic
T4047 23093-23098 UBERON:0006314 denotes fluid
T4046 23051-23058 UBERON:0000479 denotes tissues
T4045 23012-23017 UBERON:0000912 denotes mucus
T4044 22983-22992 UBERON:0000160 denotes intestine
T4043 22954-22959 UBERON:0000912 denotes mucus
T4042 22908-22924 GO:0006955 denotes immune responses
T4041 22908-22914 UBERON:0002405 denotes immune
T4040 22892-22898 UBERON:0000479 denotes tissue
T4039 22841-22852 CL:0000775 denotes neutrophils
T4038 22824-22852 GO:0072672 denotes extravasation of neutrophils
T4037 22766-22771 PR:000001467 denotes Icam1
T3392 16829-16833 GO:0016265 denotes died
T3391 16800-16804 NCBITaxon:10088 denotes mice
T3390 16713-16717 CHEBI:33290 denotes chow
T3389 16682-16686 GO:0016265 denotes died
T3388 16656-16660 NCBITaxon:10088 denotes mice
T3387 16618-16622 CHEBI:33290 denotes chow
T3386 16592-16596 NCBITaxon:10088 denotes mice
T3385 16534-16538 CHEBI:33290 denotes chow
T3384 16445-16449 NCBITaxon:10088 denotes Mice
T3383 16428-16432 CHEBI:33290 denotes chow
T3382 16377-16392 UBERON:0002108 denotes small intestine
T3381 16351-16356 UBERON:0000912 denotes mucus
T3380 16264-16268 NCBITaxon:10088 denotes mice
T3379 16240-16244 CHEBI:33290 denotes chow
T3378 16234-16239 NCBITaxon:10088 denotes mouse
T3377 16215-16218 GO:0007631 denotes fed
T3376 16206-16210 NCBITaxon:10088 denotes mice
T3375 16162-16172 UBERON:0000160 denotes intestinal
T3374 16134-16144 UBERON:0000160 denotes intestinal
T3373 16126-16130 NCBITaxon:10088 denotes mice
T3372 16114-16119 GO:0016265 denotes death
T37 254-258 SO:0000704 denotes gene
T38 340-345 SO:0000704 denotes genes
T39 351-361 UBERON:0000160 denotes intestines
T40 365-369 PR:000001044 denotes Cftr
T41 380-384 NCBITaxon:10088 denotes mice
T42 389-393 NCBITaxon:10088 denotes mice
T43 395-399 PR:000001044 denotes Cftr
T44 445-450 UBERON:0000912 denotes mucus
T45 491-499 UBERON:0007109 denotes meconium
T46 517-527 UBERON:0000160 denotes intestinal
T47 594-601 SO:0000704 denotes genetic
T48 620-624 NCBITaxon:10088 denotes mice
T49 672-676 NCBITaxon:10088 denotes mice
T50 701-706 NCBITaxon:10088 denotes mouse
T51 707-711 CHEBI:33290 denotes chow
T52 738-753 UBERON:0002108 denotes small intestine
T53 856-866 UBERON:0000160 denotes intestinal
T54 906-910 NCBITaxon:10088 denotes mice
T55 922-929 SO:0000704 denotes genetic
T56 988-992 NCBITaxon:10088 denotes mice
T57 1058-1068 UBERON:0000160 denotes intestinal
T58 1086-1090 NCBITaxon:10088 denotes mice
T59 1159-1162 GO:0007631 denotes fed
T60 1167-1172 NCBITaxon:10088 denotes mouse
T61 1173-1177 CHEBI:33290 denotes chow
T62 1192-1202 UBERON:0000160 denotes intestinal
T63 1262-1267 SO:0000704 denotes genes
T64 1321-1326 UBERON:0000912 denotes mucus
T610 2476-2486 UBERON:0001264 denotes pancreatic
T611 2500-2505 NCBITaxon:9606 denotes human
T612 2556-2560 PR:000001044 denotes CFTR
T613 2608-2612 PR:000001044 denotes CFTR
T614 2633-2647 _FRAGMENT denotes destruction of
T615 2661-2667 GO:0016271 denotes tissue
T616 2652-2660 UBERON:0002330 denotes exocrine
T617 2661-2667 UBERON:0000479 denotes tissue
T618 2681-2691 UBERON:0001264 denotes pancreatic
T619 2747-2753 UBERON:0000062 denotes organs
T620 2768-2775 UBERON:0001005 denotes airways
T621 2780-2790 UBERON:0000160 denotes intestines
T622 2829-2833 PR:000001044 denotes CFTR
T623 2865-2869 PR:000001044 denotes CFTR
T624 2920-2925 SO:0000704 denotes genes
T625 3009-3019 UBERON:0001264 denotes pancreatic
T626 3056-3065 GO:0007586 denotes digestion
T627 3123-3127 PR:000001044 denotes CFTR
T628 3190-3194 UBERON:0000165 denotes oral
T629 3252-3256 CHEBI:37527 denotes acid
T630 3320-3329 GO:0007586 denotes digestion
T631 3348-3357 CHEBI:33284 denotes nutrients
T632 3405-3414 CHEBI:33284 denotes nutrients
T633 3478-3482 UBERON:0000165 denotes oral
T634 3572-3577 UBERON:0000912 denotes mucus
T635 3601-3610 UBERON:0000160 denotes intestine
T636 3659-3664 UBERON:0000912 denotes Mucus
T637 3699-3702 UBERON:0001555 denotes gut
T638 3749-3757 UBERON:0007109 denotes meconium
T639 3773-3779 UBERON:0007023 denotes adults
T640 3795-3805 UBERON:0000160 denotes intestinal
T641 3862-3869 UBERON:0001005 denotes airways
T642 3911-3921 UBERON:0000160 denotes intestines
T643 4000-4004 PR:000001044 denotes CFTR
T644 4005-4009 SO:0000704 denotes gene
T645 4068-4075 SO:0000704 denotes genetic
T646 4104-4109 NCBITaxon:9606 denotes human
T647 4123-4134 SO:0000704 denotes genetically
T648 4143-4147 NCBITaxon:10088 denotes mice
T649 4177-4182 SO:0000704 denotes genes
T650 4268-4272 NCBITaxon:10088 denotes mice
T651 4286-4293 SO:0000704 denotes genetic
T652 4319-4324 NCBITaxon:10088 denotes mouse
T653 4362-4372 UBERON:0000160 denotes intestinal
T654 4426-4435 GO:0065007 denotes regulated
T655 4477-4481 PR:000001044 denotes CFTR
T656 4507-4517 SO:0001024 denotes haplotypes
T657 4525-4540 SO:0005858 denotes syntenic region
T658 4544-4549 NCBITaxon:9606 denotes human
T659 4668-4673 NCBITaxon:10088 denotes mouse
T660 4710-4714 UBERON:0002048 denotes lung
T661 4743-4759 CL:0000842 denotes mononuclear cell
T662 4747-4754 GO:0005634 denotes nuclear
T663 4760-4772 UBERON:0005169 denotes interstitial
T664 4805-4810 NCBITaxon:10088 denotes mouse
T665 4811-4818 UBERON:0001005 denotes airways
T666 4884-4890 UBERON:0001005 denotes airway
T667 4924-4928 NCBITaxon:10088 denotes mice
T668 5019-5023 NCBITaxon:10088 denotes mice
T669 5093-5103 UBERON:0001264 denotes pancreatic
T670 5127-5131 NCBITaxon:10088 denotes mice
T671 5176-5180 NCBITaxon:10088 denotes mice
T677 5530-5540 UBERON:0000160 denotes intestinal
T1438 5686-5690 NCBITaxon:10088 denotes mice
T1439 5754-5758 NCBITaxon:10088 denotes mice
T1440 5796-5800 NCBITaxon:10088 denotes mice
T1441 5869-5873 NCBITaxon:10088 denotes mice
T1442 5944-5948 NCBITaxon:10088 denotes mice
T1443 6016-6020 NCBITaxon:10088 denotes mice
T1444 6087-6091 NCBITaxon:10088 denotes mice
T1445 6213-6217 NCBITaxon:10088 denotes mice
T1446 6391-6395 NCBITaxon:10088 denotes mice
T1824 9372-9378 PR:000006534 denotes Muclin
T1741 6905-6909 NCBITaxon:10088 denotes mice
T1742 6947-6957 GO:0010467 denotes expression
T1743 7011-7015 NCBITaxon:10088 denotes mice
T1744 7077-7092 UBERON:0002108 denotes small intestine
T1745 7130-7137 SO:0000704 denotes genetic
T1746 7158-7168 GO:0010467 denotes expression
T1747 7192-7197 SO:0000704 denotes genes
T1748 7250-7254 SO:0000704 denotes gene
T1749 7250-7265 GO:0010467 denotes gene expression
T1750 7267-7277 GO:0010467 denotes Expression
T1751 7295-7300 SO:0000704 denotes genes
T1752 7334-7338 NCBITaxon:10088 denotes mice
T1753 7356-7363 SO:0000704 denotes genetic
T1754 7377-7386 CL:0000097 denotes Mast cell
T1755 7377-7397 PR:000010903 denotes Mast cell protease 2
T1756 7399-7404 PR:000010903 denotes Mcpt2
T1757 7436-7446 CL:0000097 denotes mast cells
T1758 7456-7466 CL:0000097 denotes mast cells
T1759 7498-7503 NCBITaxon:10088 denotes mouse
T1760 7504-7513 UBERON:0000160 denotes intestine
T1761 7515-7543 PR:000009913 denotes Leucine-rich α2 glycoprotein
T1762 7531-7543 CHEBI:17089 denotes glycoprotein
T1763 7545-7549 PR:000009913 denotes Lrg1
T1764 7588-7599 CL:0000775 denotes neutrophils
T1765 7638-7643 NCBITaxon:10088 denotes mouse
T1766 7644-7653 UBERON:0000160 denotes intestine
T1767 7664-7668 SO:0000704 denotes gene
T1768 7686-7733 PR:000009913 denotes leucine-rich high endothelial cell glycoprotein
T1769 7704-7715 UBERON:0001986 denotes endothelial
T1770 7704-7720 CL:0000115 denotes endothelial cell
T1771 7721-7733 CHEBI:17089 denotes glycoprotein
T1772 7735-7739 PR:000009913 denotes Lrhg
T1773 7783-7794 UBERON:0001986 denotes endothelial
T1774 7795-7802 UBERON:0001979 denotes venules
T1775 7832-7839 UBERON:0000479 denotes tissues
T1776 7869-7882 GO:0030097 denotes Hematopoietic
T1777 7869-7887 CL:0000988 denotes Hematopoietic cell
T1778 7888-7898 SO:0000673 denotes transcript
T1779 7930-7935 UBERON:0000178 denotes blood
T1780 7930-7940 CL:0000081 denotes blood cell
T1781 7936-7954 GO:0008283 denotes cell proliferation
T1782 7963-7973 GO:0010467 denotes expression
T1783 8008-8013 NCBITaxon:10088 denotes mouse
T1784 8014-8029 UBERON:0002108 denotes small intestine
T1785 8031-8036 UBERON:0001977 denotes Serum
T1786 8031-8047 PR:000015919 denotes Serum amyloid A3
T1787 8037-8044 CHEBI:60425 denotes amyloid
T1788 8049-8053 PR:000015919 denotes SAA3
T1789 8067-8078 GO:0006953 denotes acute phase
T1790 8079-8083 SO:0000704 denotes gene
T1791 8092-8102 GO:0010467 denotes expression
T1792 8106-8123 UBERON:0013636 denotes villus epithelial
T1793 8113-8129 CL:0000066 denotes epithelial cells
T1794 8156-8165 UBERON:0000160 denotes intestine
T1795 8167-8201 PR:000015394 denotes Suppressor of cytokine signaling 3
T1796 8181-8199 GO:0019221 denotes cytokine signaling
T1797 8203-8208 PR:000015394 denotes SOCS3
T1798 8240-8244 SO:0000704 denotes gene
T1799 8269-8272 PR:000025748 denotes JAK
T1800 8269-8285 GO:0007259 denotes JAK-STAT pathway
T1801 8273-8277 PR:000001933 denotes STAT
T1802 8294-8304 GO:0010467 denotes expression
T1803 8331-8340 UBERON:0000160 denotes intestine
T1804 8342-8348 PR:000006534 denotes Muclin
T1805 8364-8369 PR:000006534 denotes dmbt1
T1806 8377-8387 GO:0010467 denotes expression
T1807 8416-8425 UBERON:0000160 denotes intestine
T1808 8435-8447 GO:0009986 denotes cell surface
T1809 8448-8460 CHEBI:17089 denotes glycoprotein
T1810 8481-8491 UBERON:0000483 denotes epithelial
T1811 8503-8511 CHEBI:36357 denotes molecule
T1812 8555-8560 PR:000010903 denotes Mcpt2
T1813 8581-8585 NCBITaxon:10088 denotes mice
T1814 8710-8715 PR:000010903 denotes Mcpt2
T1815 8716-8726 GO:0010467 denotes expression
T1816 8787-8791 PR:000009913 denotes Lrg1
T1817 8792-8796 PR:000009913 denotes Lrhg
T1818 8797-8807 GO:0010467 denotes expression
T1819 8846-8850 NCBITaxon:10088 denotes mice
T1820 8995-8999 PR:000015919 denotes SAA3
T1821 9040-9044 NCBITaxon:10088 denotes mice
T1822 9160-9165 PR:000015394 denotes SOCS3
T1823 9203-9207 NCBITaxon:10088 denotes mice
T1825 9386-9395 GO:0010467 denotes expressed
T1826 9420-9429 UBERON:0000160 denotes intestine
T1827 9484-9494 GO:0010467 denotes expression
T1828 9507-9511 NCBITaxon:10088 denotes mice
T1829 9593-9602 GO:0010467 denotes expressed
T1830 9627-9631 NCBITaxon:10088 denotes mice
T1831 9690-9700 GO:0010467 denotes expression
T1832 10544-10548 SO:0000704 denotes gene
T1833 10544-10559 GO:0010467 denotes gene expression
T1834 10683-10690 NCBITaxon:33208 denotes animals
T1835 10723-10733 GO:0071514 denotes imprinting
T2657 11036-11040 CHEBI:33290 denotes chow
T2658 11058-11071 CHEBI:29149 denotes periodic acid
T2659 11135-11150 UBERON:0002108 denotes small intestine
T2660 11151-11158 UBERON:0000479 denotes tissues
T2661 11188-11203 UBERON:0002108 denotes small intestine
T2662 11233-11240 SO:0000704 denotes genetic
T2663 11271-11288 UBERON:0001983 denotes intestinal crypts
T2664 11405-11422 UBERON:0013636 denotes villus epithelium
T2665 11451-11463 CL:0000160 denotes goblet cells
T2666 11503-11510 UBERON:0000479 denotes tissues
T2667 11529-11538 UBERON:0000160 denotes intestine
T2668 11545-11549 NCBITaxon:10088 denotes mice
T2669 11560-11567 SO:0000704 denotes genetic
T2670 11605-11611 UBERON:0001983 denotes crypts
T2671 11637-11642 UBERON:0000912 denotes mucus
T2672 11657-11661 NCBITaxon:10088 denotes mice
T2673 11695-11700 UBERON:0000912 denotes mucus
T2674 11722-11726 NCBITaxon:10088 denotes mice
T2675 11775-11780 UBERON:0000912 denotes mucus
T2676 11787-11791 NCBITaxon:10088 denotes mice
T2677 11834-11839 NCBITaxon:10088 denotes mouse
T2678 11843-11848 NCBITaxon:10088 denotes mouse
T2679 11858-11862 NCBITaxon:10088 denotes mice
T2680 11890-11896 UBERON:0001983 denotes crypts
T2681 11913-11918 UBERON:0000912 denotes mucus
T2682 11927-11932 UBERON:0001983 denotes crypt
T2683 11971-11975 NCBITaxon:10088 denotes mice
T2684 11991-11996 UBERON:0000912 denotes mucus
T2685 12004-12010 UBERON:0001983 denotes crypts
T2686 12048-12053 UBERON:0000912 denotes mucus
T2687 12096-12100 NCBITaxon:10088 denotes mice
T2688 12176-12181 UBERON:0000912 denotes mucus
T2689 12196-12201 UBERON:0000912 denotes mucus
T2690 12235-12240 UBERON:0000912 denotes mucus
T2691 12278-12282 NCBITaxon:10088 denotes mice
T2692 12316-12321 UBERON:0001983 denotes crypt
T2693 12340-12345 UBERON:0000912 denotes mucus
T2694 12374-12378 NCBITaxon:10088 denotes mice
T2695 13472-13479 SO:0000704 denotes genetic
T2696 13570-13575 UBERON:0000912 denotes mucus
T2697 13586-13601 UBERON:0002108 denotes small intestine
T2698 13674-13678 SO:0000704 denotes gene
T2699 13674-13689 GO:0010467 denotes gene expression
T2700 13736-13746 GO:0010467 denotes expression
T2701 13754-13764 UBERON:0000160 denotes intestinal
T2702 13765-13776 CL:0000160 denotes goblet cell
T2703 13783-13787 SO:0000704 denotes gene
T2704 13789-13793 PR:000010764 denotes Muc2
T2705 13808-13817 UBERON:0000160 denotes intestine
T2706 13822-13826 NCBITaxon:10088 denotes mice
T2707 13857-13861 PR:000010764 denotes Muc2
T2708 13948-13952 NCBITaxon:10088 denotes mice
T2709 14004-14008 PR:000010764 denotes Muc2
T2710 14124-14129 UBERON:0000912 denotes mucus
T2711 14180-14184 PR:000010764 denotes Muc2
T2712 14200-14215 UBERON:0002108 denotes small intestine
T2713 14337-14342 UBERON:0000912 denotes mucus
T2714 14390-14394 SO:0000704 denotes gene
T2715 14390-14405 GO:0010467 denotes gene expression
T3366 14411-14415 NCBITaxon:10088 denotes mice
T3367 14514-14518 PR:000001044 denotes Cftr
T3368 14524-14528 NCBITaxon:10088 denotes mice
T3369 14707-14711 NCBITaxon:10088 denotes mice
T3370 14889-14893 NCBITaxon:10088 denotes mice
T3371 15098-15102 NCBITaxon:10088 denotes mice
T6567 6427-6434 SO:0000704 denotes genetic
T6568 6468-6472 NCBITaxon:10088 denotes mice
T6569 6498-6502 NCBITaxon:10088 denotes mice
T6715 9785-9792 SO:0000704 denotes genetic
T6716 9820-9824 SO:0000704 denotes gene
T6717 9820-9835 GO:0010467 denotes gene expression
T6718 9842-9847 NCBITaxon:10088 denotes mouse
T6719 9848-9863 UBERON:0002108 denotes small intestine
T6720 9869-9879 GO:0010467 denotes expression
T6721 9942-9946 SO:0000704 denotes gene
T6722 9956-9963 SO:0000112 denotes primers
T6723 10053-10057 NCBITaxon:10088 denotes mice
T6724 10296-10301 SO:0000704 denotes genes
T6725 10326-10330 NCBITaxon:10088 denotes mice
T6726 10368-10372 NCBITaxon:10088 denotes mice
T6727 10484-10488 SO:0000704 denotes gene
T6912 12442-12457 UBERON:0002108 denotes small intestine
T6913 12478-12482 NCBITaxon:10088 denotes mice
T6914 12500-12507 SO:0000704 denotes genetic
T6915 12521-12527 UBERON:0000479 denotes Tissue
T6916 12639-12654 UBERON:0002108 denotes small intestine
T6917 12817-12823 UBERON:0000479 denotes tissue
T6918 12851-12857 UBERON:0001983 denotes crypts
T6919 12915-12921 UBERON:0000479 denotes tissue
T6920 12948-12953 UBERON:0001983 denotes crypt
T6921 13010-13015 UBERON:0000912 denotes mucus
T6922 13037-13041 NCBITaxon:10088 denotes mice
T6923 13071-13077 UBERON:0001983 denotes crypts
T6924 13135-13141 UBERON:0001983 denotes crypts
T6925 13181-13185 NCBITaxon:10088 denotes mice
T6926 13230-13236 UBERON:0001983 denotes crypts
T6927 13267-13272 UBERON:0001983 denotes crypt
T6928 13286-13291 UBERON:0000912 denotes mucus
T6929 13326-13330 NCBITaxon:10088 denotes mice
T7368 15129-15133 PR:000001044 denotes Cftr
T7369 15178-15182 PR:000001044 denotes Cftr
T7423 18759-18763 NCBITaxon:10088 denotes mice
T7422 18728-18734 SO:0001026 denotes Genome
T1437 5583-5587 NCBITaxon:10088 denotes mice
T30 10-17 SO:0000704 denotes genetic
T31 51-61 UBERON:0000160 denotes intestinal
T32 88-93 NCBITaxon:10088 denotes mouse
T33 195-246 PR:000001044 denotes cystic fibrosis transmembrane conductance regulator
T34 211-236 GO:0055085 denotes transmembrane conductance
T35 216-224 GO:0016020 denotes membrane
T36 248-252 PR:000001044 denotes CFTR
T65 1347-1364 UBERON:0001983 denotes intestinal crypts
T66 1606-1612 SO:0001026 denotes genome
T67 1622-1628 SO:0001023 denotes allele
T68 1968-1973 NCBITaxon:10088 denotes mouse
T69 1974-1989 UBERON:0002108 denotes small intestine
T70 1994-2000 NCBITaxon:33208 denotes animal
T71 2055-2060 SO:0000704 denotes genes
T72 2125-2132 SO:0000704 denotes genetic
T73 2153-2163 UBERON:0000160 denotes intestinal
T2648 10739-10743 NCBITaxon:10088 denotes mice
T2649 10778-10788 UBERON:0000160 denotes intestinal
T2650 10789-10794 UBERON:0000912 denotes mucus
T2651 10860-10865 NCBITaxon:10088 denotes mouse
T2652 10866-10881 UBERON:0002108 denotes small intestine
T2653 10905-10910 UBERON:0000912 denotes mucus
T2654 10914-10931 UBERON:0001983 denotes intestinal crypts
T2655 10996-11001 GO:0016265 denotes death
T2656 11011-11015 NCBITaxon:10088 denotes mice
T598 2238-2289 PR:000001044 denotes cystic fibrosis transmembrane conductance regulator
T599 2254-2279 GO:0055085 denotes transmembrane conductance
T600 2259-2267 GO:0016020 denotes membrane
T601 2291-2295 PR:000001044 denotes CFTR
T602 2297-2301 SO:0000704 denotes gene
T603 2368-2372 PR:000001044 denotes CFTR
T604 2411-2421 UBERON:0000483 denotes epithelial
T605 2422-2438 GO:0006821 denotes transport of Cl-
T606 2422-2434 _FRAGMENT denotes transport of
T607 2443-2448 GO:0015701 denotes HCO3-
T608 2435-2438 CHEBI:17996 denotes Cl-
T609 2443-2448 CHEBI:17544 denotes HCO3-
T672 5232-5236 NCBITaxon:10088 denotes mice
T673 5316-5322 SO:0001026 denotes Genome
T674 5328-5334 SO:0001023 denotes allele
T675 5420-5430 UBERON:0000160 denotes intestinal
T676 5476-5481 SO:0000704 denotes genes
R372 T607 T606 _lexicallyChainedTo HCO3-,transport of
R373 T615 T614 _lexicallyChainedTo tissue,destruction of
R2530 T4011 T4010 _lexicallyChainedTo IL-10 interleukin family,member of
R2531 T4030 T4029 _lexicallyChainedTo cells,differentiation of
R4152 T6229 T6228 _lexicallyChainedTo primers,forward
R4153 T6231 T6230 _lexicallyChainedTo primers,reverse