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PMC:116589 / 2157-3160 JSONTXT

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Id Subject Object Predicate Lexical cue
T646 0-3 DT denotes The
T647 4-8 NN denotes ease
T648 47-56 VB denotes establish
T649 9-11 IN denotes of
T650 12-24 VBG denotes manipulating
T651 25-28 PRP$ denotes its
T652 29-35 NN denotes genome
T653 36-39 VBZ denotes has
T654 40-46 VBN denotes helped
T655 57-60 DT denotes the
T656 61-66 NN denotes mouse
T657 67-69 IN denotes as
T658 70-73 DT denotes the
T659 88-96 NN denotes organism
T660 74-81 JJ denotes premier
T661 82-87 NN denotes model
T662 97-100 IN denotes for
T663 101-110 JJ denotes mammalian
T664 119-126 NNS denotes studies
T665 111-118 JJ denotes genetic
T666 126-127 . denotes .
T667 127-276 sentence denotes Both directed and random mutagenesis approaches, including the technologies of transgenesis and gene targeting in ES cells, have become commonplace.
T668 128-132 CC denotes Both
T669 133-141 JJ denotes directed
T670 165-175 NNS denotes approaches
T671 142-145 CC denotes and
T672 146-152 JJ denotes random
T673 153-164 NN denotes mutagenesis
T674 257-263 VBN denotes become
T675 175-177 , denotes ,
T676 177-186 VBG denotes including
T677 187-190 DT denotes the
T678 191-203 NNS denotes technologies
T679 204-206 IN denotes of
T680 207-219 NN denotes transgenesis
T681 220-223 CC denotes and
T682 224-228 NN denotes gene
T683 229-238 NN denotes targeting
T684 239-241 IN denotes in
T685 242-244 NN denotes ES
T686 245-250 NNS denotes cells
T687 250-252 , denotes ,
T688 252-256 VBP denotes have
T689 264-275 JJ denotes commonplace
T690 275-276 . denotes .
T691 276-443 sentence denotes Genetically manipulated mice, often incorporating gene-based reporters, are frequently being used to model and understand mammalian development and disease processes.
T692 277-288 RB denotes Genetically
T693 289-300 VBN denotes manipulated
T694 301-305 NNS denotes mice
T695 370-374 VBN denotes used
T696 305-307 , denotes ,
T697 307-312 RB denotes often
T698 313-326 VBG denotes incorporating
T699 327-331 NN denotes gene
T700 332-337 VBN denotes based
T701 331-332 HYPH denotes -
T702 338-347 NNS denotes reporters
T703 347-349 , denotes ,
T704 349-352 VBP denotes are
T705 353-363 RB denotes frequently
T706 364-369 VBG denotes being
T707 375-377 TO denotes to
T708 378-383 VB denotes model
T709 384-387 CC denotes and
T710 388-398 VB denotes understand
T711 399-408 JJ denotes mammalian
T712 409-420 NN denotes development
T713 421-424 CC denotes and
T714 425-432 NN denotes disease
T715 433-442 NNS denotes processes
T716 442-443 . denotes .
T717 443-711 sentence denotes Fluorescent protein reporters currently represent a superior alternative to other gene-based reporters such as the bacterial lacZ or human placental alkaline phosphatase in that their visualization is non-invasive, and as such does not require chromogenic substrates.
T718 444-455 JJ denotes Fluorescent
T719 456-463 NN denotes protein
T720 464-473 NNS denotes reporters
T721 484-493 VBP denotes represent
T722 474-483 RB denotes currently
T723 494-495 DT denotes a
T724 505-516 NN denotes alternative
T725 496-504 JJ denotes superior
T726 517-519 IN denotes to
T727 520-525 JJ denotes other
T728 537-546 NNS denotes reporters
T729 526-530 NN denotes gene
T730 531-536 VBN denotes based
T731 530-531 HYPH denotes -
T732 547-551 JJ denotes such
T733 552-554 IN denotes as
T734 555-558 DT denotes the
T735 569-573 NN denotes lacZ
T736 559-568 JJ denotes bacterial
T737 574-576 CC denotes or
T738 577-582 JJ denotes human
T739 583-592 JJ denotes placental
T740 602-613 NN denotes phosphatase
T741 593-601 JJ denotes alkaline
T742 614-616 IN denotes in
T743 642-644 VBZ denotes is
T744 617-621 DT denotes that
T745 622-627 PRP$ denotes their
T746 628-641 NN denotes visualization
T747 645-657 JJ denotes non-invasive
T748 657-659 , denotes ,
T749 659-662 CC denotes and
T750 663-665 IN denotes as
T751 680-687 VB denotes require
T752 666-670 JJ denotes such
T753 671-675 VBZ denotes does
T754 676-679 RB denotes not
T755 688-699 JJ denotes chromogenic
T756 700-710 NNS denotes substrates
T757 710-711 . denotes .
T758 711-833 sentence denotes Fluorescence can be monitored in real-time in vivo and in situ, and has the added advantage in that it can be quantified.
T759 712-724 NN denotes Fluorescence
T760 732-741 VBN denotes monitored
T761 725-728 MD denotes can
T762 729-731 VB denotes be
T763 742-744 IN denotes in
T764 745-749 JJ denotes real
T765 750-754 NN denotes time
T766 749-750 HYPH denotes -
T767 755-757 FW denotes in
T768 758-762 FW denotes vivo
T769 763-766 CC denotes and
T770 767-769 FW denotes in
T771 770-774 FW denotes situ
T772 774-776 , denotes ,
T773 776-779 CC denotes and
T774 780-783 VBZ denotes has
T775 784-787 DT denotes the
T776 794-803 NN denotes advantage
T777 788-793 VBN denotes added
T778 804-806 IN denotes in
T779 822-832 VBN denotes quantified
T780 807-811 IN denotes that
T781 812-814 PRP denotes it
T782 815-818 MD denotes can
T783 819-821 VB denotes be
T784 832-833 . denotes .
T785 833-1003 sentence denotes The prototype fluorescent protein reporter is green fluorescent protein (GFP, reviewed in [3]), which is derived from the bioluminescent jellyfish Aequorea Victoria [1].
T786 834-837 DT denotes The
T787 868-876 NN denotes reporter
T788 838-847 NN denotes prototype
T789 848-859 JJ denotes fluorescent
T790 860-867 NN denotes protein
T791 877-879 VBZ denotes is
T792 880-885 JJ denotes green
T793 898-905 NN denotes protein
T794 886-897 JJ denotes fluorescent
T795 906-907 -LRB- denotes (
T796 907-910 NN denotes GFP
T797 910-912 , denotes ,
T798 912-920 VBN denotes reviewed
T799 921-923 IN denotes in
T800 924-925 -LRB- denotes [
T801 925-926 CD denotes 3
T802 926-927 -RRB- denotes ]
T803 927-928 -RRB- denotes )
T804 928-930 , denotes ,
T805 930-935 WDT denotes which
T806 939-946 VBN denotes derived
T807 936-938 VBZ denotes is
T808 947-951 IN denotes from
T809 952-955 DT denotes the
T810 971-980 NN denotes jellyfish
T811 956-970 JJ denotes bioluminescent
T812 981-989 NNP denotes Aequorea
T813 990-998 NNP denotes Victoria
T814 999-1000 -LRB- denotes [
T815 1000-1001 CD denotes 1
T816 1001-1002 -RRB- denotes ]
T817 1002-1003 . denotes .
R354 T646 T647 det The,ease
R355 T647 T648 nsubj ease,establish
R356 T649 T647 prep of,ease
R357 T650 T649 pcomp manipulating,of
R358 T651 T652 poss its,genome
R359 T652 T650 dobj genome,manipulating
R360 T653 T648 aux has,establish
R361 T654 T648 aux helped,establish
R362 T655 T656 det the,mouse
R363 T656 T648 dobj mouse,establish
R364 T657 T648 prep as,establish
R365 T658 T659 det the,organism
R366 T659 T657 pobj organism,as
R367 T660 T659 amod premier,organism
R368 T661 T659 compound model,organism
R369 T662 T659 prep for,organism
R370 T663 T664 amod mammalian,studies
R371 T664 T662 pobj studies,for
R372 T665 T664 amod genetic,studies
R373 T666 T648 punct .,establish
R374 T668 T669 preconj Both,directed
R375 T669 T670 amod directed,approaches
R376 T670 T674 nsubj approaches,become
R377 T671 T669 cc and,directed
R378 T672 T669 conj random,directed
R379 T673 T670 compound mutagenesis,approaches
R380 T675 T670 punct ", ",approaches
R381 T676 T670 prep including,approaches
R382 T677 T678 det the,technologies
R383 T678 T676 pobj technologies,including
R384 T679 T678 prep of,technologies
R385 T680 T679 pobj transgenesis,of
R386 T681 T680 cc and,transgenesis
R387 T682 T683 compound gene,targeting
R388 T683 T680 conj targeting,transgenesis
R389 T684 T683 prep in,targeting
R390 T685 T686 compound ES,cells
R391 T686 T684 pobj cells,in
R392 T687 T674 punct ", ",become
R393 T688 T674 aux have,become
R394 T689 T674 acomp commonplace,become
R395 T690 T674 punct .,become
R396 T692 T693 advmod Genetically,manipulated
R397 T693 T694 amod manipulated,mice
R398 T694 T695 nsubjpass mice,used
R399 T696 T694 punct ", ",mice
R400 T697 T698 advmod often,incorporating
R401 T698 T694 acl incorporating,mice
R402 T699 T700 npadvmod gene,based
R403 T700 T702 amod based,reporters
R404 T701 T700 punct -,based
R405 T702 T698 dobj reporters,incorporating
R406 T703 T695 punct ", ",used
R407 T704 T695 aux are,used
R408 T705 T695 advmod frequently,used
R409 T706 T695 auxpass being,used
R410 T707 T708 aux to,model
R411 T708 T695 advcl model,used
R412 T709 T708 cc and,model
R413 T710 T708 conj understand,model
R414 T711 T712 amod mammalian,development
R415 T712 T710 dobj development,understand
R416 T713 T712 cc and,development
R417 T714 T715 compound disease,processes
R418 T715 T712 conj processes,development
R419 T716 T695 punct .,used
R420 T718 T719 amod Fluorescent,protein
R421 T719 T720 compound protein,reporters
R422 T720 T721 nsubj reporters,represent
R423 T722 T721 advmod currently,represent
R424 T723 T724 det a,alternative
R425 T724 T721 dobj alternative,represent
R426 T725 T724 amod superior,alternative
R427 T726 T724 prep to,alternative
R428 T727 T728 amod other,reporters
R429 T728 T726 pobj reporters,to
R430 T729 T730 npadvmod gene,based
R431 T730 T728 amod based,reporters
R432 T731 T730 punct -,based
R433 T732 T733 amod such,as
R434 T733 T728 prep as,reporters
R435 T734 T735 det the,lacZ
R436 T735 T733 pobj lacZ,as
R437 T736 T735 amod bacterial,lacZ
R438 T737 T735 cc or,lacZ
R439 T738 T739 amod human,placental
R440 T739 T740 amod placental,phosphatase
R441 T740 T735 conj phosphatase,lacZ
R442 T741 T740 amod alkaline,phosphatase
R443 T742 T743 mark in,is
R444 T743 T721 advcl is,represent
R445 T744 T743 mark that,is
R446 T745 T746 poss their,visualization
R447 T746 T743 nsubj visualization,is
R448 T747 T743 acomp non-invasive,is
R449 T748 T743 punct ", ",is
R450 T749 T743 cc and,is
R451 T750 T751 prep as,require
R452 T751 T743 conj require,is
R453 T752 T750 amod such,as
R454 T753 T751 aux does,require
R455 T754 T751 neg not,require
R456 T755 T756 amod chromogenic,substrates
R457 T756 T751 dobj substrates,require
R458 T757 T721 punct .,represent
R459 T759 T760 nsubjpass Fluorescence,monitored
R460 T761 T760 aux can,monitored
R461 T762 T760 auxpass be,monitored
R462 T763 T760 prep in,monitored
R463 T764 T765 amod real,time
R464 T765 T763 pobj time,in
R465 T766 T765 punct -,time
R466 T767 T768 advmod in,vivo
R467 T768 T760 advmod vivo,monitored
R468 T769 T768 cc and,vivo
R469 T770 T771 advmod in,situ
R470 T771 T768 conj situ,vivo
R471 T772 T760 punct ", ",monitored
R472 T773 T760 cc and,monitored
R473 T774 T760 conj has,monitored
R474 T775 T776 det the,advantage
R475 T776 T774 dobj advantage,has
R476 T777 T776 amod added,advantage
R477 T778 T779 mark in,quantified
R478 T779 T774 advcl quantified,has
R479 T780 T779 mark that,quantified
R480 T781 T779 nsubjpass it,quantified
R481 T782 T779 aux can,quantified
R482 T783 T779 auxpass be,quantified
R483 T784 T760 punct .,monitored
R484 T786 T787 det The,reporter
R485 T787 T791 nsubj reporter,is
R486 T788 T787 nmod prototype,reporter
R487 T789 T790 amod fluorescent,protein
R488 T790 T787 compound protein,reporter
R489 T792 T793 amod green,protein
R490 T793 T791 attr protein,is
R491 T794 T793 amod fluorescent,protein
R492 T795 T793 punct (,protein
R493 T796 T793 appos GFP,protein
R494 T797 T793 punct ", ",protein
R495 T798 T793 acl reviewed,protein
R496 T799 T798 prep in,reviewed
R497 T800 T799 punct [,in
R498 T801 T799 pobj 3,in
R499 T802 T799 punct ],in
R500 T803 T793 punct ),protein
R501 T804 T793 punct ", ",protein
R502 T805 T806 dep which,derived
R503 T806 T793 relcl derived,protein
R504 T807 T806 auxpass is,derived
R505 T808 T806 prep from,derived
R506 T809 T810 det the,jellyfish
R507 T810 T808 pobj jellyfish,from
R508 T811 T810 amod bioluminescent,jellyfish
R509 T812 T813 compound Aequorea,Victoria
R510 T813 T810 appos Victoria,jellyfish
R511 T814 T815 punct [,1
R512 T815 T791 parataxis 1,is
R513 T816 T815 punct ],1
R514 T817 T791 punct .,is

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T597 12-24 SO_EXT:sequence_alteration_process denotes manipulating
T598 29-35 SO_EXT:0001026 denotes genome
T599 61-66 NCBITaxon:10088 denotes mouse
T600 88-96 NCBITaxon:1 denotes organism
T601 101-110 NCBITaxon:40674 denotes mammalian
T602 111-118 SO_EXT:0000704 denotes genetic
T603 153-164 SO_EXT:sequence_alteration_process denotes mutagenesis
T604 207-219 SO_EXT:transgenesis denotes transgenesis
T605 224-228 SO_EXT:0000704 denotes gene
T606 242-250 CL:0002322 denotes ES cells
T607 245-250 CL_GO_EXT:cell denotes cells
T608 277-288 SO_EXT:0000704 denotes Genetically
T609 289-300 SO_EXT:sequence_alteration_process denotes manipulated
T610 301-305 NCBITaxon:10088 denotes mice
T611 327-331 SO_EXT:0000704 denotes gene
T612 399-408 NCBITaxon:40674 denotes mammalian
T613 456-463 CHEBI_PR_EXT:protein denotes protein
T614 526-530 SO_EXT:0000704 denotes gene
T615 559-568 NCBITaxon:2 denotes bacterial
T616 569-573 PR_EXT:000033987 denotes lacZ
T617 577-582 NCBITaxon:9606 denotes human
T618 583-592 UBERON:0001987 denotes placental
T619 583-613 PR_EXT:000003969 denotes placental alkaline phosphatase
T620 593-613 GO_PR_EXT:alkaline_phosphatase denotes alkaline phosphatase
T621 688-699 CHEBI_EXT:75050 denotes chromogenic
T622 860-867 CHEBI_PR_EXT:protein denotes protein
T623 898-905 CHEBI_PR_EXT:protein denotes protein
T624 956-970 GO:0008218 denotes bioluminescent
T625 971-980 NCBITaxon:6142 denotes jellyfish
T626 981-998 NCBITaxon:6100 denotes Aequorea Victoria

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T568 29-35 SO:0001026 denotes genome
T569 61-66 NCBITaxon:10088 denotes mouse
T570 88-96 NCBITaxon:1 denotes organism
T571 101-110 NCBITaxon:40674 denotes mammalian
T572 111-118 SO:0000704 denotes genetic
T573 224-228 SO:0000704 denotes gene
T574 242-250 CL:0002322 denotes ES cells
T575 277-288 SO:0000704 denotes Genetically
T576 301-305 NCBITaxon:10088 denotes mice
T577 327-331 SO:0000704 denotes gene
T578 399-408 NCBITaxon:40674 denotes mammalian
T579 526-530 SO:0000704 denotes gene
T580 559-568 NCBITaxon:2 denotes bacterial
T581 569-573 PR:000033987 denotes lacZ
T582 577-582 NCBITaxon:9606 denotes human
T583 583-592 UBERON:0001987 denotes placental
T584 583-613 PR:000003969 denotes placental alkaline phosphatase
T585 688-699 CHEBI:75050 denotes chromogenic
T586 956-970 GO:0008218 denotes bioluminescent
T587 971-980 NCBITaxon:6142 denotes jellyfish
T588 981-998 NCBITaxon:6100 denotes Aequorea Victoria

2_test

Id Subject Object Predicate Lexical cue
12079497-7480149-8577590 925-926 7480149 denotes 3
12079497-8303295-8577591 1000-1001 8303295 denotes 1