PMC:116589 / 14902-16465 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T6343","span":{"begin":0,"end":4},"obj":"JJ"},{"id":"T6344","span":{"begin":27,"end":40},"obj":"NN"},{"id":"T6345","span":{"begin":5,"end":17},"obj":"JJ"},{"id":"T6346","span":{"begin":18,"end":26},"obj":"NN"},{"id":"T6347","span":{"begin":41,"end":43},"obj":"IN"},{"id":"T6348","span":{"begin":44,"end":47},"obj":"DT"},{"id":"T6349","span":{"begin":48,"end":54},"obj":"NNS"},{"id":"T6350","span":{"begin":55,"end":57},"obj":"IN"},{"id":"T6351","span":{"begin":58,"end":63},"obj":"JJ"},{"id":"T6352","span":{"begin":64,"end":72},"obj":"NNS"},{"id":"T6353","span":{"begin":72,"end":73},"obj":"."},{"id":"T6354","span":{"begin":73,"end":207},"obj":"sentence"},{"id":"T6355","span":{"begin":74,"end":77},"obj":"DT"},{"id":"T6356","span":{"begin":78,"end":84},"obj":"NNS"},{"id":"T6357","span":{"begin":85,"end":91},"obj":"VBP"},{"id":"T6358","span":{"begin":92,"end":96},"obj":"JJ"},{"id":"T6359","span":{"begin":97,"end":102},"obj":"NN"},{"id":"T6360","span":{"begin":110,"end":119},"obj":"NNS"},{"id":"T6361","span":{"begin":103,"end":109},"obj":"JJ"},{"id":"T6362","span":{"begin":120,"end":128},"obj":"VBN"},{"id":"T6363","span":{"begin":129,"end":131},"obj":"IN"},{"id":"T6364","span":{"begin":132,"end":145},"obj":"RB"},{"id":"T6365","span":{"begin":146,"end":151},"obj":"VBG"},{"id":"T6366","span":{"begin":152,"end":156},"obj":"NN"},{"id":"T6367","span":{"begin":166,"end":173},"obj":"NNS"},{"id":"T6368","span":{"begin":157,"end":160},"obj":"CC"},{"id":"T6369","span":{"begin":161,"end":165},"obj":"NN"},{"id":"T6370","span":{"begin":174,"end":179},"obj":"IN"},{"id":"T6371","span":{"begin":180,"end":184},"obj":"JJ"},{"id":"T6372","span":{"begin":185,"end":190},"obj":"NN"},{"id":"T6373","span":{"begin":191,"end":206},"obj":"NN"},{"id":"T6374","span":{"begin":206,"end":207},"obj":"."},{"id":"T6375","span":{"begin":207,"end":277},"obj":"sentence"},{"id":"T6376","span":{"begin":208,"end":215},"obj":"NNS"},{"id":"T6377","span":{"begin":234,"end":245},"obj":"VBN"},{"id":"T6378","span":{"begin":216,"end":218},"obj":"IN"},{"id":"T6379","span":{"begin":219,"end":229},"obj":"NNS"},{"id":"T6380","span":{"begin":230,"end":233},"obj":"VBP"},{"id":"T6381","span":{"begin":246,"end":248},"obj":"IN"},{"id":"T6382","span":{"begin":249,"end":252},"obj":"DT"},{"id":"T6383","span":{"begin":257,"end":262},"obj":"NN"},{"id":"T6384","span":{"begin":253,"end":256},"obj":"JJ"},{"id":"T6385","span":{"begin":263,"end":265},"obj":"IN"},{"id":"T6386","span":{"begin":266,"end":270},"obj":"DT"},{"id":"T6387","span":{"begin":271,"end":276},"obj":"NN"},{"id":"T6388","span":{"begin":276,"end":277},"obj":"."},{"id":"T6389","span":{"begin":277,"end":356},"obj":"sentence"},{"id":"T6390","span":{"begin":278,"end":279},"obj":"-LRB-"},{"id":"T6391","span":{"begin":279,"end":280},"obj":"LS"},{"id":"T6392","span":{"begin":284,"end":289},"obj":"NN"},{"id":"T6393","span":{"begin":280,"end":281},"obj":"SYM"},{"id":"T6394","span":{"begin":281,"end":282},"obj":"LS"},{"id":"T6395","span":{"begin":282,"end":283},"obj":"-RRB-"},{"id":"T6396","span":{"begin":290,"end":293},"obj":"CC"},{"id":"T6397","span":{"begin":294,"end":302},"obj":"NN"},{"id":"T6398","span":{"begin":303,"end":307},"obj":"IN"},{"id":"T6399","span":{"begin":308,"end":314},"obj":"JJ"},{"id":"T6400","span":{"begin":315,"end":321},"obj":"JJ"},{"id":"T6401","span":{"begin":314,"end":315},"obj":"HYPH"},{"id":"T6402","span":{"begin":347,"end":355},"obj":"NNS"},{"id":"T6403","span":{"begin":322,"end":328},"obj":"JJ"},{"id":"T6404","span":{"begin":329,"end":340},"obj":"NN"},{"id":"T6405","span":{"begin":328,"end":329},"obj":"HYPH"},{"id":"T6406","span":{"begin":341,"end":346},"obj":"JJ"},{"id":"T6407","span":{"begin":355,"end":356},"obj":"."},{"id":"T6408","span":{"begin":356,"end":399},"obj":"sentence"},{"id":"T6409","span":{"begin":357,"end":358},"obj":"-LRB-"},{"id":"T6410","span":{"begin":358,"end":359},"obj":"LS"},{"id":"T6411","span":{"begin":361,"end":365},"obj":"NN"},{"id":"T6412","span":{"begin":359,"end":360},"obj":"-RRB-"},{"id":"T6413","span":{"begin":366,"end":368},"obj":"IN"},{"id":"T6414","span":{"begin":369,"end":372},"obj":"DT"},{"id":"T6415","span":{"begin":373,"end":380},"obj":"NN"},{"id":"T6416","span":{"begin":381,"end":383},"obj":"IN"},{"id":"T6417","span":{"begin":384,"end":386},"obj":"DT"},{"id":"T6418","span":{"begin":393,"end":398},"obj":"NN"},{"id":"T6419","span":{"begin":387,"end":392},"obj":"JJ"},{"id":"T6420","span":{"begin":398,"end":399},"obj":"."},{"id":"T6421","span":{"begin":399,"end":618},"obj":"sentence"},{"id":"T6422","span":{"begin":400,"end":401},"obj":"-LRB-"},{"id":"T6423","span":{"begin":401,"end":402},"obj":"LS"},{"id":"T6424","span":{"begin":421,"end":425},"obj":"NN"},{"id":"T6425","span":{"begin":402,"end":403},"obj":"-RRB-"},{"id":"T6426","span":{"begin":404,"end":409},"obj":"NN"},{"id":"T6427","span":{"begin":410,"end":412},"obj":"NN"},{"id":"T6428","span":{"begin":409,"end":410},"obj":"HYPH"},{"id":"T6429","span":{"begin":413,"end":420},"obj":"NN"},{"id":"T6430","span":{"begin":426,"end":428},"obj":"IN"},{"id":"T6431","span":{"begin":429,"end":438},"obj":"NN"},{"id":"T6432","span":{"begin":439,"end":441},"obj":"IN"},{"id":"T6433","span":{"begin":442,"end":443},"obj":"DT"},{"id":"T6434","span":{"begin":453,"end":458},"obj":"NN"},{"id":"T6435","span":{"begin":444,"end":452},"obj":"JJ"},{"id":"T6436","span":{"begin":459,"end":468},"obj":"VBN"},{"id":"T6437","span":{"begin":469,"end":471},"obj":"IN"},{"id":"T6438","span":{"begin":472,"end":483},"obj":"NN"},{"id":"T6439","span":{"begin":484,"end":486},"obj":"IN"},{"id":"T6440","span":{"begin":487,"end":490},"obj":"CD"},{"id":"T6441","span":{"begin":499,"end":506},"obj":"NNS"},{"id":"T6442","span":{"begin":491,"end":498},"obj":"JJ"},{"id":"T6443","span":{"begin":506,"end":508},"obj":","},{"id":"T6444","span":{"begin":508,"end":511},"obj":"CD"},{"id":"T6445","span":{"begin":512,"end":522},"obj":"JJ"},{"id":"T6446","span":{"begin":523,"end":526},"obj":"IN"},{"id":"T6447","span":{"begin":527,"end":530},"obj":"DT"},{"id":"T6448","span":{"begin":548,"end":557},"obj":"NN"},{"id":"T6449","span":{"begin":531,"end":534},"obj":"NN"},{"id":"T6450","span":{"begin":535,"end":539},"obj":"NN"},{"id":"T6451","span":{"begin":534,"end":535},"obj":"HYPH"},{"id":"T6452","span":{"begin":540,"end":541},"obj":"-LRB-"},{"id":"T6453","span":{"begin":541,"end":546},"obj":"JJ"},{"id":"T6454","span":{"begin":546,"end":547},"obj":"-RRB-"},{"id":"T6455","span":{"begin":558,"end":561},"obj":"CC"},{"id":"T6456","span":{"begin":562,"end":565},"obj":"DT"},{"id":"T6457","span":{"begin":566,"end":571},"obj":"JJ"},{"id":"T6458","span":{"begin":572,"end":582},"obj":"JJ"},{"id":"T6459","span":{"begin":583,"end":586},"obj":"IN"},{"id":"T6460","span":{"begin":587,"end":590},"obj":"DT"},{"id":"T6461","span":{"begin":608,"end":617},"obj":"NN"},{"id":"T6462","span":{"begin":591,"end":594},"obj":"NN"},{"id":"T6463","span":{"begin":595,"end":599},"obj":"NN"},{"id":"T6464","span":{"begin":594,"end":595},"obj":"HYPH"},{"id":"T6465","span":{"begin":600,"end":601},"obj":"-LRB-"},{"id":"T6466","span":{"begin":601,"end":606},"obj":"JJ"},{"id":"T6467","span":{"begin":606,"end":607},"obj":"-RRB-"},{"id":"T6468","span":{"begin":617,"end":618},"obj":"."},{"id":"T6469","span":{"begin":618,"end":700},"obj":"sentence"},{"id":"T6470","span":{"begin":619,"end":622},"obj":"DT"},{"id":"T6471","span":{"begin":623,"end":630},"obj":"NNS"},{"id":"T6472","span":{"begin":669,"end":672},"obj":"VBP"},{"id":"T6473","span":{"begin":631,"end":633},"obj":"IN"},{"id":"T6474","span":{"begin":634,"end":640},"obj":"JJ"},{"id":"T6475","span":{"begin":641,"end":646},"obj":"JJ"},{"id":"T6476","span":{"begin":640,"end":641},"obj":"HYPH"},{"id":"T6477","span":{"begin":656,"end":668},"obj":"NN"},{"id":"T6478","span":{"begin":647,"end":650},"obj":"CC"},{"id":"T6479","span":{"begin":651,"end":655},"obj":"JJ"},{"id":"T6480","span":{"begin":673,"end":680},"obj":"RB"},{"id":"T6481","span":{"begin":681,"end":689},"obj":"RB"},{"id":"T6482","span":{"begin":690,"end":699},"obj":"JJ"},{"id":"T6483","span":{"begin":699,"end":700},"obj":"."},{"id":"T6484","span":{"begin":700,"end":809},"obj":"sentence"},{"id":"T6485","span":{"begin":701,"end":704},"obj":"DT"},{"id":"T6486","span":{"begin":705,"end":715},"obj":"NNS"},{"id":"T6487","span":{"begin":746,"end":755},"obj":"VBP"},{"id":"T6488","span":{"begin":716,"end":718},"obj":"IN"},{"id":"T6489","span":{"begin":719,"end":722},"obj":"DT"},{"id":"T6490","span":{"begin":723,"end":729},"obj":"NNS"},{"id":"T6491","span":{"begin":730,"end":732},"obj":"IN"},{"id":"T6492","span":{"begin":733,"end":745},"obj":"NN"},{"id":"T6493","span":{"begin":756,"end":759},"obj":"DT"},{"id":"T6494","span":{"begin":774,"end":779},"obj":"NNS"},{"id":"T6495","span":{"begin":760,"end":773},"obj":"JJ"},{"id":"T6496","span":{"begin":780,"end":787},"obj":"JJ"},{"id":"T6497","span":{"begin":788,"end":794},"obj":"IN"},{"id":"T6498","span":{"begin":795,"end":798},"obj":"DT"},{"id":"T6499","span":{"begin":799,"end":808},"obj":"NN"},{"id":"T6500","span":{"begin":808,"end":809},"obj":"."},{"id":"T6501","span":{"begin":809,"end":930},"obj":"sentence"},{"id":"T6502","span":{"begin":810,"end":811},"obj":"-LRB-"},{"id":"T6503","span":{"begin":811,"end":812},"obj":"LS"},{"id":"T6504","span":{"begin":823,"end":831},"obj":"NN"},{"id":"T6505","span":{"begin":812,"end":813},"obj":"-RRB-"},{"id":"T6506","span":{"begin":814,"end":822},"obj":"JJ"},{"id":"T6507","span":{"begin":832,"end":841},"obj":"VBN"},{"id":"T6508","span":{"begin":842,"end":844},"obj":"IN"},{"id":"T6509","span":{"begin":845,"end":856},"obj":"NN"},{"id":"T6510","span":{"begin":857,"end":859},"obj":"IN"},{"id":"T6511","span":{"begin":860,"end":861},"obj":"DT"},{"id":"T6512","span":{"begin":862,"end":868},"obj":"NN"},{"id":"T6513","span":{"begin":869,"end":879},"obj":"JJ"},{"id":"T6514","span":{"begin":880,"end":883},"obj":"IN"},{"id":"T6515","span":{"begin":884,"end":887},"obj":"DT"},{"id":"T6516","span":{"begin":897,"end":906},"obj":"NN"},{"id":"T6517","span":{"begin":888,"end":891},"obj":"NN"},{"id":"T6518","span":{"begin":892,"end":896},"obj":"NN"},{"id":"T6519","span":{"begin":891,"end":892},"obj":"HYPH"},{"id":"T6520","span":{"begin":907,"end":911},"obj":"IN"},{"id":"T6521","span":{"begin":912,"end":915},"obj":"NN"},{"id":"T6522","span":{"begin":916,"end":920},"obj":"NN"},{"id":"T6523","span":{"begin":915,"end":916},"obj":"HYPH"},{"id":"T6524","span":{"begin":924,"end":929},"obj":"NNS"},{"id":"T6525","span":{"begin":921,"end":923},"obj":"NN"},{"id":"T6526","span":{"begin":929,"end":930},"obj":"."},{"id":"T6527","span":{"begin":930,"end":1031},"obj":"sentence"},{"id":"T6528","span":{"begin":931,"end":934},"obj":"DT"},{"id":"T6529","span":{"begin":946,"end":952},"obj":"NNS"},{"id":"T6530","span":{"begin":935,"end":945},"obj":"JJ"},{"id":"T6531","span":{"begin":969,"end":978},"obj":"VBP"},{"id":"T6532","span":{"begin":953,"end":955},"obj":"IN"},{"id":"T6533","span":{"begin":956,"end":968},"obj":"NN"},{"id":"T6534","span":{"begin":979,"end":982},"obj":"DT"},{"id":"T6535","span":{"begin":997,"end":1002},"obj":"NNS"},{"id":"T6536","span":{"begin":983,"end":996},"obj":"JJ"},{"id":"T6537","span":{"begin":1003,"end":1010},"obj":"JJ"},{"id":"T6538","span":{"begin":1011,"end":1017},"obj":"IN"},{"id":"T6539","span":{"begin":1018,"end":1021},"obj":"DT"},{"id":"T6540","span":{"begin":1022,"end":1030},"obj":"NN"},{"id":"T6541","span":{"begin":1030,"end":1031},"obj":"."},{"id":"T6542","span":{"begin":1031,"end":1096},"obj":"sentence"},{"id":"T6543","span":{"begin":1032,"end":1033},"obj":"-LRB-"},{"id":"T6544","span":{"begin":1033,"end":1034},"obj":"LS"},{"id":"T6545","span":{"begin":1036,"end":1041},"obj":"NN"},{"id":"T6546","span":{"begin":1034,"end":1035},"obj":"-RRB-"},{"id":"T6547","span":{"begin":1042,"end":1046},"obj":"IN"},{"id":"T6548","span":{"begin":1047,"end":1048},"obj":"DT"},{"id":"T6549","span":{"begin":1088,"end":1095},"obj":"NN"},{"id":"T6550","span":{"begin":1049,"end":1055},"obj":"JJ"},{"id":"T6551","span":{"begin":1056,"end":1062},"obj":"JJ"},{"id":"T6552","span":{"begin":1055,"end":1056},"obj":"HYPH"},{"id":"T6553","span":{"begin":1063,"end":1069},"obj":"JJ"},{"id":"T6554","span":{"begin":1070,"end":1081},"obj":"NN"},{"id":"T6555","span":{"begin":1069,"end":1070},"obj":"HYPH"},{"id":"T6556","span":{"begin":1082,"end":1087},"obj":"JJ"},{"id":"T6557","span":{"begin":1095,"end":1096},"obj":"."},{"id":"T6558","span":{"begin":1096,"end":1264},"obj":"sentence"},{"id":"T6559","span":{"begin":1097,"end":1098},"obj":"DT"},{"id":"T6560","span":{"begin":1115,"end":1121},"obj":"NN"},{"id":"T6561","span":{"begin":1099,"end":1114},"obj":"JJ"},{"id":"T6562","span":{"begin":1126,"end":1136},"obj":"VBN"},{"id":"T6563","span":{"begin":1122,"end":1125},"obj":"VBD"},{"id":"T6564","span":{"begin":1137,"end":1141},"obj":"IN"},{"id":"T6565","span":{"begin":1142,"end":1145},"obj":"CD"},{"id":"T6566","span":{"begin":1146,"end":1152},"obj":"NNS"},{"id":"T6567","span":{"begin":1153,"end":1155},"obj":"IN"},{"id":"T6568","span":{"begin":1156,"end":1158},"obj":"NN"},{"id":"T6569","span":{"begin":1159,"end":1164},"obj":"NNS"},{"id":"T6570","span":{"begin":1164,"end":1166},"obj":","},{"id":"T6571","span":{"begin":1166,"end":1169},"obj":"CD"},{"id":"T6572","span":{"begin":1170,"end":1178},"obj":"VBG"},{"id":"T6573","span":{"begin":1179,"end":1182},"obj":"DT"},{"id":"T6574","span":{"begin":1192,"end":1201},"obj":"NN"},{"id":"T6575","span":{"begin":1183,"end":1186},"obj":"NN"},{"id":"T6576","span":{"begin":1187,"end":1191},"obj":"NN"},{"id":"T6577","span":{"begin":1186,"end":1187},"obj":"HYPH"},{"id":"T6578","span":{"begin":1202,"end":1203},"obj":"-LRB-"},{"id":"T6579","span":{"begin":1203,"end":1208},"obj":"JJ"},{"id":"T6580","span":{"begin":1208,"end":1209},"obj":"-RRB-"},{"id":"T6581","span":{"begin":1210,"end":1213},"obj":"CC"},{"id":"T6582","span":{"begin":1214,"end":1217},"obj":"DT"},{"id":"T6583","span":{"begin":1218,"end":1223},"obj":"JJ"},{"id":"T6584","span":{"begin":1224,"end":1232},"obj":"VBG"},{"id":"T6585","span":{"begin":1233,"end":1236},"obj":"DT"},{"id":"T6586","span":{"begin":1246,"end":1255},"obj":"NN"},{"id":"T6587","span":{"begin":1237,"end":1240},"obj":"NN"},{"id":"T6588","span":{"begin":1241,"end":1245},"obj":"NN"},{"id":"T6589","span":{"begin":1240,"end":1241},"obj":"HYPH"},{"id":"T6590","span":{"begin":1256,"end":1257},"obj":"-LRB-"},{"id":"T6591","span":{"begin":1257,"end":1262},"obj":"JJ"},{"id":"T6592","span":{"begin":1262,"end":1263},"obj":"-RRB-"},{"id":"T6593","span":{"begin":1263,"end":1264},"obj":"."},{"id":"T6594","span":{"begin":1264,"end":1344},"obj":"sentence"},{"id":"T6595","span":{"begin":1265,"end":1267},"obj":"DT"},{"id":"T6596","span":{"begin":1274,"end":1280},"obj":"NN"},{"id":"T6597","span":{"begin":1268,"end":1273},"obj":"JJ"},{"id":"T6598","span":{"begin":1294,"end":1306},"obj":"VBN"},{"id":"T6599","span":{"begin":1281,"end":1284},"obj":"VBZ"},{"id":"T6600","span":{"begin":1285,"end":1293},"obj":"RB"},{"id":"T6601","span":{"begin":1307,"end":1310},"obj":"CC"},{"id":"T6602","span":{"begin":1311,"end":1322},"obj":"VBN"},{"id":"T6603","span":{"begin":1323,"end":1326},"obj":"DT"},{"id":"T6604","span":{"begin":1333,"end":1337},"obj":"NN"},{"id":"T6605","span":{"begin":1327,"end":1332},"obj":"NN"},{"id":"T6606","span":{"begin":1338,"end":1339},"obj":"-LRB-"},{"id":"T6607","span":{"begin":1339,"end":1342},"obj":"NN"},{"id":"T6608","span":{"begin":1342,"end":1343},"obj":"-RRB-"},{"id":"T6609","span":{"begin":1343,"end":1344},"obj":"."},{"id":"T6610","span":{"begin":1344,"end":1563},"obj":"sentence"},{"id":"T6611","span":{"begin":1345,"end":1349},"obj":"VB"},{"id":"T6612","span":{"begin":1350,"end":1354},"obj":"IN"},{"id":"T6613","span":{"begin":1390,"end":1397},"obj":"VBZ"},{"id":"T6614","span":{"begin":1355,"end":1361},"obj":"IN"},{"id":"T6615","span":{"begin":1362,"end":1364},"obj":"IN"},{"id":"T6616","span":{"begin":1365,"end":1370},"obj":"NN"},{"id":"T6617","span":{"begin":1371,"end":1374},"obj":"CC"},{"id":"T6618","span":{"begin":1375,"end":1383},"obj":"NN"},{"id":"T6619","span":{"begin":1384,"end":1389},"obj":"EX"},{"id":"T6620","span":{"begin":1398,"end":1400},"obj":"TO"},{"id":"T6621","span":{"begin":1401,"end":1403},"obj":"VB"},{"id":"T6622","span":{"begin":1404,"end":1408},"obj":"RBR"},{"id":"T6623","span":{"begin":1409,"end":1421},"obj":"JJ"},{"id":"T6624","span":{"begin":1448,"end":1460},"obj":"NN"},{"id":"T6625","span":{"begin":1422,"end":1426},"obj":"JJ"},{"id":"T6626","span":{"begin":1427,"end":1431},"obj":"JJ"},{"id":"T6627","span":{"begin":1426,"end":1427},"obj":"HYPH"},{"id":"T6628","span":{"begin":1432,"end":1434},"obj":"CC"},{"id":"T6629","span":{"begin":1435,"end":1440},"obj":"JJ"},{"id":"T6630","span":{"begin":1441,"end":1447},"obj":"JJ"},{"id":"T6631","span":{"begin":1440,"end":1441},"obj":"HYPH"},{"id":"T6632","span":{"begin":1461,"end":1468},"obj":"JJ"},{"id":"T6633","span":{"begin":1469,"end":1471},"obj":"IN"},{"id":"T6634","span":{"begin":1472,"end":1475},"obj":"DT"},{"id":"T6635","span":{"begin":1476,"end":1481},"obj":"NN"},{"id":"T6636","span":{"begin":1481,"end":1483},"obj":","},{"id":"T6637","span":{"begin":1483,"end":1491},"obj":"RB"},{"id":"T6638","span":{"begin":1492,"end":1502},"obj":"VBG"},{"id":"T6639","span":{"begin":1503,"end":1510},"obj":"JJR"},{"id":"T6640","span":{"begin":1516,"end":1529},"obj":"NN"},{"id":"T6641","span":{"begin":1511,"end":1515},"obj":"NN"},{"id":"T6642","span":{"begin":1530,"end":1536},"obj":"IN"},{"id":"T6643","span":{"begin":1537,"end":1540},"obj":"DT"},{"id":"T6644","span":{"begin":1541,"end":1548},"obj":"NN"},{"id":"T6645","span":{"begin":1549,"end":1551},"obj":"IN"},{"id":"T6646","span":{"begin":1552,"end":1556},"obj":"DT"},{"id":"T6647","span":{"begin":1557,"end":1562},"obj":"NN"},{"id":"T6648","span":{"begin":1562,"end":1563},"obj":"."}],"relations":[{"id":"R3707","pred":"amod","subj":"T6343","obj":"T6344"},{"id":"R3708","pred":"amod","subj":"T6345","obj":"T6344"},{"id":"R3709","pred":"compound","subj":"T6346","obj":"T6344"},{"id":"R3710","pred":"prep","subj":"T6347","obj":"T6344"},{"id":"R3711","pred":"det","subj":"T6348","obj":"T6349"},{"id":"R3712","pred":"pobj","subj":"T6349","obj":"T6347"},{"id":"R3713","pred":"prep","subj":"T6350","obj":"T6349"},{"id":"R3714","pred":"amod","subj":"T6351","obj":"T6352"},{"id":"R3715","pred":"pobj","subj":"T6352","obj":"T6350"},{"id":"R3716","pred":"punct","subj":"T6353","obj":"T6344"},{"id":"R3717","pred":"det","subj":"T6355","obj":"T6356"},{"id":"R3718","pred":"nsubj","subj":"T6356","obj":"T6357"},{"id":"R3719","pred":"amod","subj":"T6358","obj":"T6359"},{"id":"R3720","pred":"nmod","subj":"T6359","obj":"T6360"},{"id":"R3721","pred":"dobj","subj":"T6360","obj":"T6357"},{"id":"R3722","pred":"amod","subj":"T6361","obj":"T6360"},{"id":"R3723","pred":"acl","subj":"T6362","obj":"T6360"},{"id":"R3724","pred":"prep","subj":"T6363","obj":"T6362"},{"id":"R3725","pred":"advmod","subj":"T6364","obj":"T6365"},{"id":"R3726","pred":"pcomp","subj":"T6365","obj":"T6363"},{"id":"R3727","pred":"nmod","subj":"T6366","obj":"T6367"},{"id":"R3728","pred":"dobj","subj":"T6367","obj":"T6365"},{"id":"R3729","pred":"cc","subj":"T6368","obj":"T6366"},{"id":"R3730","pred":"conj","subj":"T6369","obj":"T6366"},{"id":"R3731","pred":"prep","subj":"T6370","obj":"T6365"},{"id":"R3732","pred":"amod","subj":"T6371","obj":"T6372"},{"id":"R3733","pred":"compound","subj":"T6372","obj":"T6373"},{"id":"R3734","pred":"pobj","subj":"T6373","obj":"T6370"},{"id":"R3735","pred":"punct","subj":"T6374","obj":"T6357"},{"id":"R3736","pred":"nsubjpass","subj":"T6376","obj":"T6377"},{"id":"R3737","pred":"prep","subj":"T6378","obj":"T6376"},{"id":"R3738","pred":"pobj","subj":"T6379","obj":"T6378"},{"id":"R3739","pred":"auxpass","subj":"T6380","obj":"T6377"},{"id":"R3740","pred":"prep","subj":"T6381","obj":"T6377"},{"id":"R3741","pred":"det","subj":"T6382","obj":"T6383"},{"id":"R3742","pred":"pobj","subj":"T6383","obj":"T6381"},{"id":"R3743","pred":"amod","subj":"T6384","obj":"T6383"},{"id":"R3744","pred":"prep","subj":"T6385","obj":"T6383"},{"id":"R3745","pred":"det","subj":"T6386","obj":"T6387"},{"id":"R3746","pred":"pobj","subj":"T6387","obj":"T6385"},{"id":"R3747","pred":"punct","subj":"T6388","obj":"T6377"},{"id":"R3748","pred":"punct","subj":"T6390","obj":"T6391"},{"id":"R3749","pred":"meta","subj":"T6391","obj":"T6392"},{"id":"R3750","pred":"punct","subj":"T6393","obj":"T6391"},{"id":"R3751","pred":"dep","subj":"T6394","obj":"T6391"},{"id":"R3752","pred":"punct","subj":"T6395","obj":"T6391"},{"id":"R3753","pred":"cc","subj":"T6396","obj":"T6392"},{"id":"R3754","pred":"conj","subj":"T6397","obj":"T6392"},{"id":"R3755","pred":"prep","subj":"T6398","obj":"T6392"},{"id":"R3756","pred":"amod","subj":"T6399","obj":"T6400"},{"id":"R3757","pred":"amod","subj":"T6400","obj":"T6402"},{"id":"R3758","pred":"punct","subj":"T6401","obj":"T6400"},{"id":"R3759","pred":"pobj","subj":"T6402","obj":"T6398"},{"id":"R3760","pred":"amod","subj":"T6403","obj":"T6404"},{"id":"R3761","pred":"nmod","subj":"T6404","obj":"T6402"},{"id":"R3762","pred":"punct","subj":"T6405","obj":"T6404"},{"id":"R3763","pred":"amod","subj":"T6406","obj":"T6402"},{"id":"R3764","pred":"punct","subj":"T6407","obj":"T6392"},{"id":"R3765","pred":"punct","subj":"T6409","obj":"T6410"},{"id":"R3766","pred":"meta","subj":"T6410","obj":"T6411"},{"id":"R3767","pred":"punct","subj":"T6412","obj":"T6410"},{"id":"R3768","pred":"prep","subj":"T6413","obj":"T6411"},{"id":"R3769","pred":"det","subj":"T6414","obj":"T6415"},{"id":"R3770","pred":"pobj","subj":"T6415","obj":"T6413"},{"id":"R3771","pred":"prep","subj":"T6416","obj":"T6415"},{"id":"R3772","pred":"det","subj":"T6417","obj":"T6418"},{"id":"R3773","pred":"pobj","subj":"T6418","obj":"T6416"},{"id":"R3774","pred":"amod","subj":"T6419","obj":"T6418"},{"id":"R3775","pred":"punct","subj":"T6420","obj":"T6411"},{"id":"R3776","pred":"punct","subj":"T6422","obj":"T6423"},{"id":"R3777","pred":"meta","subj":"T6423","obj":"T6424"},{"id":"R3778","pred":"punct","subj":"T6425","obj":"T6423"},{"id":"R3779","pred":"compound","subj":"T6426","obj":"T6427"},{"id":"R3780","pred":"compound","subj":"T6427","obj":"T6424"},{"id":"R3781","pred":"punct","subj":"T6428","obj":"T6427"},{"id":"R3782","pred":"compound","subj":"T6429","obj":"T6424"},{"id":"R3783","pred":"prep","subj":"T6430","obj":"T6424"},{"id":"R3784","pred":"pobj","subj":"T6431","obj":"T6430"},{"id":"R3785","pred":"prep","subj":"T6432","obj":"T6431"},{"id":"R3786","pred":"det","subj":"T6433","obj":"T6434"},{"id":"R3787","pred":"pobj","subj":"T6434","obj":"T6432"},{"id":"R3788","pred":"amod","subj":"T6435","obj":"T6434"},{"id":"R3789","pred":"acl","subj":"T6436","obj":"T6424"},{"id":"R3790","pred":"prep","subj":"T6437","obj":"T6436"},{"id":"R3791","pred":"pobj","subj":"T6438","obj":"T6437"},{"id":"R3792","pred":"prep","subj":"T6439","obj":"T6438"},{"id":"R3793","pred":"nummod","subj":"T6440","obj":"T6441"},{"id":"R3794","pred":"pobj","subj":"T6441","obj":"T6439"},{"id":"R3795","pred":"amod","subj":"T6442","obj":"T6441"},{"id":"R3796","pred":"punct","subj":"T6443","obj":"T6441"},{"id":"R3797","pred":"appos","subj":"T6444","obj":"T6441"},{"id":"R3798","pred":"amod","subj":"T6445","obj":"T6444"},{"id":"R3799","pred":"prep","subj":"T6446","obj":"T6445"},{"id":"R3800","pred":"det","subj":"T6447","obj":"T6448"},{"id":"R3801","pred":"pobj","subj":"T6448","obj":"T6446"},{"id":"R3802","pred":"nmod","subj":"T6449","obj":"T6450"},{"id":"R3803","pred":"nmod","subj":"T6450","obj":"T6448"},{"id":"R3804","pred":"punct","subj":"T6451","obj":"T6450"},{"id":"R3805","pred":"punct","subj":"T6452","obj":"T6448"},{"id":"R3806","pred":"amod","subj":"T6453","obj":"T6448"},{"id":"R3807","pred":"punct","subj":"T6454","obj":"T6448"},{"id":"R3808","pred":"cc","subj":"T6455","obj":"T6444"},{"id":"R3809","pred":"det","subj":"T6456","obj":"T6457"},{"id":"R3810","pred":"conj","subj":"T6457","obj":"T6444"},{"id":"R3811","pred":"amod","subj":"T6458","obj":"T6457"},{"id":"R3812","pred":"prep","subj":"T6459","obj":"T6458"},{"id":"R3813","pred":"det","subj":"T6460","obj":"T6461"},{"id":"R3814","pred":"pobj","subj":"T6461","obj":"T6459"},{"id":"R3815","pred":"nmod","subj":"T6462","obj":"T6463"},{"id":"R3816","pred":"nmod","subj":"T6463","obj":"T6461"},{"id":"R3817","pred":"punct","subj":"T6464","obj":"T6463"},{"id":"R3818","pred":"punct","subj":"T6465","obj":"T6461"},{"id":"R3819","pred":"amod","subj":"T6466","obj":"T6461"},{"id":"R3820","pred":"punct","subj":"T6467","obj":"T6461"},{"id":"R3821","pred":"punct","subj":"T6468","obj":"T6424"},{"id":"R3822","pred":"det","subj":"T6470","obj":"T6471"},{"id":"R3823","pred":"nsubj","subj":"T6471","obj":"T6472"},{"id":"R3824","pred":"prep","subj":"T6473","obj":"T6471"},{"id":"R3825","pred":"amod","subj":"T6474","obj":"T6475"},{"id":"R3826","pred":"amod","subj":"T6475","obj":"T6477"},{"id":"R3827","pred":"punct","subj":"T6476","obj":"T6475"},{"id":"R3828","pred":"pobj","subj":"T6477","obj":"T6473"},{"id":"R3829","pred":"cc","subj":"T6478","obj":"T6475"},{"id":"R3830","pred":"conj","subj":"T6479","obj":"T6475"},{"id":"R3831","pred":"advmod","subj":"T6480","obj":"T6472"},{"id":"R3832","pred":"advmod","subj":"T6481","obj":"T6482"},{"id":"R3833","pred":"acomp","subj":"T6482","obj":"T6472"},{"id":"R3834","pred":"punct","subj":"T6483","obj":"T6472"},{"id":"R3835","pred":"det","subj":"T6485","obj":"T6486"},{"id":"R3836","pred":"nsubj","subj":"T6486","obj":"T6487"},{"id":"R3837","pred":"prep","subj":"T6488","obj":"T6486"},{"id":"R3838","pred":"det","subj":"T6489","obj":"T6490"},{"id":"R3839","pred":"pobj","subj":"T6490","obj":"T6488"},{"id":"R3840","pred":"prep","subj":"T6491","obj":"T6490"},{"id":"R3841","pred":"pobj","subj":"T6492","obj":"T6491"},{"id":"R3842","pred":"det","subj":"T6493","obj":"T6494"},{"id":"R3843","pred":"dobj","subj":"T6494","obj":"T6487"},{"id":"R3844","pred":"amod","subj":"T6495","obj":"T6494"},{"id":"R3845","pred":"amod","subj":"T6496","obj":"T6494"},{"id":"R3846","pred":"prep","subj":"T6497","obj":"T6496"},{"id":"R3847","pred":"det","subj":"T6498","obj":"T6499"},{"id":"R3848","pred":"pobj","subj":"T6499","obj":"T6497"},{"id":"R3849","pred":"punct","subj":"T6500","obj":"T6487"},{"id":"R3850","pred":"punct","subj":"T6502","obj":"T6503"},{"id":"R3851","pred":"meta","subj":"T6503","obj":"T6504"},{"id":"R3852","pred":"punct","subj":"T6505","obj":"T6503"},{"id":"R3853","pred":"amod","subj":"T6506","obj":"T6504"},{"id":"R3854","pred":"acl","subj":"T6507","obj":"T6504"},{"id":"R3855","pred":"prep","subj":"T6508","obj":"T6507"},{"id":"R3856","pred":"pobj","subj":"T6509","obj":"T6508"},{"id":"R3857","pred":"prep","subj":"T6510","obj":"T6509"},{"id":"R3858","pred":"det","subj":"T6511","obj":"T6512"},{"id":"R3859","pred":"pobj","subj":"T6512","obj":"T6510"},{"id":"R3860","pred":"amod","subj":"T6513","obj":"T6512"},{"id":"R3861","pred":"prep","subj":"T6514","obj":"T6507"},{"id":"R3862","pred":"det","subj":"T6515","obj":"T6516"},{"id":"R3863","pred":"pobj","subj":"T6516","obj":"T6514"},{"id":"R3864","pred":"compound","subj":"T6517","obj":"T6518"},{"id":"R3865","pred":"compound","subj":"T6518","obj":"T6516"},{"id":"R3866","pred":"punct","subj":"T6519","obj":"T6518"},{"id":"R3867","pred":"prep","subj":"T6520","obj":"T6507"},{"id":"R3868","pred":"compound","subj":"T6521","obj":"T6522"},{"id":"R3869","pred":"compound","subj":"T6522","obj":"T6524"},{"id":"R3870","pred":"punct","subj":"T6523","obj":"T6522"},{"id":"R3871","pred":"pobj","subj":"T6524","obj":"T6520"},{"id":"R3872","pred":"compound","subj":"T6525","obj":"T6524"},{"id":"R3873","pred":"punct","subj":"T6526","obj":"T6504"},{"id":"R3874","pred":"det","subj":"T6528","obj":"T6529"},{"id":"R3875","pred":"nsubj","subj":"T6529","obj":"T6531"},{"id":"R3876","pred":"amod","subj":"T6530","obj":"T6529"},{"id":"R3877","pred":"prep","subj":"T6532","obj":"T6529"},{"id":"R3878","pred":"pobj","subj":"T6533","obj":"T6532"},{"id":"R3879","pred":"det","subj":"T6534","obj":"T6535"},{"id":"R3880","pred":"dobj","subj":"T6535","obj":"T6531"},{"id":"R3881","pred":"amod","subj":"T6536","obj":"T6535"},{"id":"R3882","pred":"amod","subj":"T6537","obj":"T6535"},{"id":"R3883","pred":"prep","subj":"T6538","obj":"T6537"},{"id":"R3884","pred":"det","subj":"T6539","obj":"T6540"},{"id":"R3885","pred":"pobj","subj":"T6540","obj":"T6538"},{"id":"R3886","pred":"punct","subj":"T6541","obj":"T6531"},{"id":"R3887","pred":"punct","subj":"T6543","obj":"T6544"},{"id":"R3888","pred":"meta","subj":"T6544","obj":"T6545"},{"id":"R3889","pred":"punct","subj":"T6546","obj":"T6544"},{"id":"R3890","pred":"prep","subj":"T6547","obj":"T6545"},{"id":"R3891","pred":"det","subj":"T6548","obj":"T6549"},{"id":"R3892","pred":"pobj","subj":"T6549","obj":"T6547"},{"id":"R3893","pred":"amod","subj":"T6550","obj":"T6551"},{"id":"R3894","pred":"amod","subj":"T6551","obj":"T6549"},{"id":"R3895","pred":"punct","subj":"T6552","obj":"T6551"},{"id":"R3896","pred":"amod","subj":"T6553","obj":"T6554"},{"id":"R3897","pred":"nmod","subj":"T6554","obj":"T6549"},{"id":"R3898","pred":"punct","subj":"T6555","obj":"T6554"},{"id":"R3899","pred":"amod","subj":"T6556","obj":"T6549"},{"id":"R3900","pred":"punct","subj":"T6557","obj":"T6545"},{"id":"R3901","pred":"det","subj":"T6559","obj":"T6560"},{"id":"R3902","pred":"nsubjpass","subj":"T6560","obj":"T6562"},{"id":"R3903","pred":"amod","subj":"T6561","obj":"T6560"},{"id":"R3904","pred":"auxpass","subj":"T6563","obj":"T6562"},{"id":"R3905","pred":"prep","subj":"T6564","obj":"T6562"},{"id":"R3906","pred":"nummod","subj":"T6565","obj":"T6566"},{"id":"R3907","pred":"pobj","subj":"T6566","obj":"T6564"},{"id":"R3908","pred":"prep","subj":"T6567","obj":"T6566"},{"id":"R3909","pred":"compound","subj":"T6568","obj":"T6569"},{"id":"R3910","pred":"pobj","subj":"T6569","obj":"T6567"},{"id":"R3911","pred":"punct","subj":"T6570","obj":"T6566"},{"id":"R3912","pred":"appos","subj":"T6571","obj":"T6566"},{"id":"R3913","pred":"acl","subj":"T6572","obj":"T6571"},{"id":"R3914","pred":"det","subj":"T6573","obj":"T6574"},{"id":"R3915","pred":"dobj","subj":"T6574","obj":"T6572"},{"id":"R3916","pred":"compound","subj":"T6575","obj":"T6576"},{"id":"R3917","pred":"compound","subj":"T6576","obj":"T6574"},{"id":"R3918","pred":"punct","subj":"T6577","obj":"T6576"},{"id":"R3919","pred":"punct","subj":"T6578","obj":"T6574"},{"id":"R3920","pred":"amod","subj":"T6579","obj":"T6574"},{"id":"R3921","pred":"punct","subj":"T6580","obj":"T6571"},{"id":"R3922","pred":"cc","subj":"T6581","obj":"T6571"},{"id":"R3923","pred":"det","subj":"T6582","obj":"T6583"},{"id":"R3924","pred":"conj","subj":"T6583","obj":"T6571"},{"id":"R3925","pred":"acl","subj":"T6584","obj":"T6583"},{"id":"R3926","pred":"det","subj":"T6585","obj":"T6586"},{"id":"R3927","pred":"dobj","subj":"T6586","obj":"T6584"},{"id":"R3928","pred":"compound","subj":"T6587","obj":"T6588"},{"id":"R3929","pred":"compound","subj":"T6588","obj":"T6586"},{"id":"R3930","pred":"punct","subj":"T6589","obj":"T6588"},{"id":"R3931","pred":"punct","subj":"T6590","obj":"T6586"},{"id":"R3932","pred":"amod","subj":"T6591","obj":"T6586"},{"id":"R3933","pred":"punct","subj":"T6592","obj":"T6562"},{"id":"R3934","pred":"punct","subj":"T6593","obj":"T6562"},{"id":"R3935","pred":"det","subj":"T6595","obj":"T6596"},{"id":"R3936","pred":"nsubj","subj":"T6596","obj":"T6598"},{"id":"R3937","pred":"amod","subj":"T6597","obj":"T6596"},{"id":"R3938","pred":"aux","subj":"T6599","obj":"T6598"},{"id":"R3939","pred":"advmod","subj":"T6600","obj":"T6598"},{"id":"R3940","pred":"cc","subj":"T6601","obj":"T6598"},{"id":"R3941","pred":"conj","subj":"T6602","obj":"T6598"},{"id":"R3942","pred":"det","subj":"T6603","obj":"T6604"},{"id":"R3943","pred":"dobj","subj":"T6604","obj":"T6602"},{"id":"R3944","pred":"compound","subj":"T6605","obj":"T6604"},{"id":"R3945","pred":"punct","subj":"T6606","obj":"T6607"},{"id":"R3946","pred":"parataxis","subj":"T6607","obj":"T6602"},{"id":"R3947","pred":"punct","subj":"T6608","obj":"T6607"},{"id":"R3948","pred":"punct","subj":"T6609","obj":"T6598"},{"id":"R3949","pred":"mark","subj":"T6612","obj":"T6613"},{"id":"R3950","pred":"ccomp","subj":"T6613","obj":"T6611"},{"id":"R3951","pred":"prep","subj":"T6614","obj":"T6613"},{"id":"R3952","pred":"prep","subj":"T6615","obj":"T6614"},{"id":"R3953","pred":"pobj","subj":"T6616","obj":"T6615"},{"id":"R3954","pred":"cc","subj":"T6617","obj":"T6616"},{"id":"R3955","pred":"conj","subj":"T6618","obj":"T6616"},{"id":"R3956","pred":"expl","subj":"T6619","obj":"T6613"},{"id":"R3957","pred":"aux","subj":"T6620","obj":"T6621"},{"id":"R3958","pred":"xcomp","subj":"T6621","obj":"T6613"},{"id":"R3959","pred":"advmod","subj":"T6622","obj":"T6623"},{"id":"R3960","pred":"amod","subj":"T6623","obj":"T6624"},{"id":"R3961","pred":"attr","subj":"T6624","obj":"T6621"},{"id":"R3962","pred":"amod","subj":"T6625","obj":"T6626"},{"id":"R3963","pred":"amod","subj":"T6626","obj":"T6624"},{"id":"R3964","pred":"punct","subj":"T6627","obj":"T6626"},{"id":"R3965","pred":"cc","subj":"T6628","obj":"T6626"},{"id":"R3966","pred":"amod","subj":"T6629","obj":"T6630"},{"id":"R3967","pred":"conj","subj":"T6630","obj":"T6626"},{"id":"R3968","pred":"punct","subj":"T6631","obj":"T6630"},{"id":"R3969","pred":"amod","subj":"T6632","obj":"T6624"},{"id":"R3970","pred":"prep","subj":"T6633","obj":"T6632"},{"id":"R3971","pred":"det","subj":"T6634","obj":"T6635"},{"id":"R3972","pred":"pobj","subj":"T6635","obj":"T6633"},{"id":"R3973","pred":"punct","subj":"T6636","obj":"T6621"},{"id":"R3974","pred":"advmod","subj":"T6637","obj":"T6638"},{"id":"R3975","pred":"advcl","subj":"T6638","obj":"T6621"},{"id":"R3976","pred":"amod","subj":"T6639","obj":"T6640"},{"id":"R3977","pred":"dobj","subj":"T6640","obj":"T6638"},{"id":"R3978","pred":"compound","subj":"T6641","obj":"T6640"},{"id":"R3979","pred":"prep","subj":"T6642","obj":"T6638"},{"id":"R3980","pred":"det","subj":"T6643","obj":"T6644"},{"id":"R3981","pred":"pobj","subj":"T6644","obj":"T6642"},{"id":"R3982","pred":"prep","subj":"T6645","obj":"T6644"},{"id":"R3983","pred":"det","subj":"T6646","obj":"T6647"},{"id":"R3984","pred":"pobj","subj":"T6647","obj":"T6645"},{"id":"R3985","pred":"punct","subj":"T6648","obj":"T6611"}],"text":"Dual non-invasive reporter visualization in the organs of adult chimeras. All images depict dark field double exposures acquired by consecutively using ECFP and EYFP filters under dark field epifluorescence. Details of aggregates are schematized at the top right of each panel. (a-c) heart and pancreas from double-tagged double-compartment adult chimeras. (a) view of the surface of an adult heart. (b) close-up surface view of ventricle of a chimeric heart generated by aggregation of two diploid morulae, one hemizygous for the CK6/ECFP (ECFP+) transgene and the other hemizygous for the YC5/EYFP (EYFP+) transgene. The regions of yellow/green and cyan fluorescence are clearly mutually exclusive. The striations in the fields of fluorescence represent the proliferative zones present within the ventricle. (c) chimeric pancreas generated by aggregation of a morula hemizygous for the YC5/EYFP transgene with CK6/ECFP ES cells. The restricted fields of fluorescence represent the proliferative zones present within the pancreas. (d) liver from a double-tagged triple-compartment adult chimera. A non-fluorescent morula was aggregated with two clumps of ES cells, one carrying the CK6/ECFP transgene (ECFP+) and the other carrying the YC5/EYFP transgene (EYFP+). An ECFP+ vessel has clonally proliferated and infiltrated the liver lobe (top). Note that unlike in heart and pancreas there appears to be more interspersed blue/cyan vs green/yellow fluorescence present in the liver, possibly reflecting greater cell intermingling during the genesis of this organ."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T6300","span":{"begin":48,"end":54},"obj":"UBERON:0000062"},{"id":"T6301","span":{"begin":58,"end":63},"obj":"UBERON:0007023"},{"id":"T6302","span":{"begin":284,"end":289},"obj":"UBERON:0000948"},{"id":"T6303","span":{"begin":294,"end":302},"obj":"UBERON:0001264"},{"id":"T6304","span":{"begin":315,"end":321},"obj":"CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process"},{"id":"T6305","span":{"begin":341,"end":346},"obj":"UBERON:0007023"},{"id":"T6306","span":{"begin":387,"end":392},"obj":"UBERON:0007023"},{"id":"T6307","span":{"begin":393,"end":398},"obj":"UBERON:0000948"},{"id":"T6308","span":{"begin":429,"end":441},"obj":"_FRAGMENT"},{"id":"T6309","span":{"begin":453,"end":458},"obj":"UBERON:0002082"},{"id":"T6310","span":{"begin":499,"end":506},"obj":"UBERON:0000085"},{"id":"T6311","span":{"begin":548,"end":557},"obj":"SO_EXT:0000902"},{"id":"T6312","span":{"begin":608,"end":617},"obj":"SO_EXT:0000902"},{"id":"T6313","span":{"begin":760,"end":773},"obj":"GO_PATO_EXT:cell_proliferation_or_proliferativity"},{"id":"T6314","span":{"begin":799,"end":808},"obj":"UBERON:0002082"},{"id":"T6315","span":{"begin":823,"end":831},"obj":"UBERON:0001264"},{"id":"T6316","span":{"begin":862,"end":868},"obj":"UBERON:0000085"},{"id":"T6317","span":{"begin":897,"end":906},"obj":"SO_EXT:0000902"},{"id":"T6318","span":{"begin":921,"end":929},"obj":"CL:0002322"},{"id":"T6319","span":{"begin":924,"end":929},"obj":"CL_GO_EXT:cell"},{"id":"T6320","span":{"begin":983,"end":996},"obj":"GO_PATO_EXT:cell_proliferation_or_proliferativity"},{"id":"T6321","span":{"begin":1022,"end":1030},"obj":"UBERON:0001264"},{"id":"T6322","span":{"begin":1036,"end":1041},"obj":"UBERON:0002107"},{"id":"T6323","span":{"begin":1056,"end":1062},"obj":"CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process"},{"id":"T6324","span":{"begin":1082,"end":1087},"obj":"UBERON:0007023"},{"id":"T6325","span":{"begin":1115,"end":1121},"obj":"UBERON:0000085"},{"id":"T6326","span":{"begin":1146,"end":1155},"obj":"_FRAGMENT"},{"id":"T6327","span":{"begin":1159,"end":1164},"obj":"UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population"},{"id":"T6328","span":{"begin":1156,"end":1164},"obj":"CL:0002322"},{"id":"T6329","span":{"begin":1159,"end":1164},"obj":"CL_GO_EXT:cell"},{"id":"T6330","span":{"begin":1192,"end":1201},"obj":"SO_EXT:0000902"},{"id":"T6331","span":{"begin":1246,"end":1255},"obj":"SO_EXT:0000902"},{"id":"T6332","span":{"begin":1274,"end":1280},"obj":"UBERON:0000055"},{"id":"T6333","span":{"begin":1285,"end":1293},"obj":"SO_EXT:sequence_cloning_process"},{"id":"T6334","span":{"begin":1294,"end":1306},"obj":"GO:0008283"},{"id":"T6335","span":{"begin":1327,"end":1337},"obj":"UBERON:0001113"},{"id":"T6336","span":{"begin":1365,"end":1370},"obj":"UBERON:0000948"},{"id":"T6337","span":{"begin":1375,"end":1383},"obj":"UBERON:0001264"},{"id":"T6338","span":{"begin":1476,"end":1481},"obj":"UBERON:0002107"},{"id":"T6339","span":{"begin":1511,"end":1515},"obj":"CL_GO_EXT:cell"},{"id":"T6340","span":{"begin":1541,"end":1551},"obj":"_FRAGMENT"},{"id":"T6341","span":{"begin":1557,"end":1562},"obj":"GO:0048513"},{"id":"T6342","span":{"begin":1557,"end":1562},"obj":"UBERON:0000062"}],"relations":[{"id":"R3704","pred":"_lexicallyChainedTo","subj":"T6309","obj":"T6308"},{"id":"R3705","pred":"_lexicallyChainedTo","subj":"T6327","obj":"T6326"},{"id":"R3706","pred":"_lexicallyChainedTo","subj":"T6341","obj":"T6340"}],"text":"Dual non-invasive reporter visualization in the organs of adult chimeras. All images depict dark field double exposures acquired by consecutively using ECFP and EYFP filters under dark field epifluorescence. Details of aggregates are schematized at the top right of each panel. (a-c) heart and pancreas from double-tagged double-compartment adult chimeras. (a) view of the surface of an adult heart. (b) close-up surface view of ventricle of a chimeric heart generated by aggregation of two diploid morulae, one hemizygous for the CK6/ECFP (ECFP+) transgene and the other hemizygous for the YC5/EYFP (EYFP+) transgene. The regions of yellow/green and cyan fluorescence are clearly mutually exclusive. The striations in the fields of fluorescence represent the proliferative zones present within the ventricle. (c) chimeric pancreas generated by aggregation of a morula hemizygous for the YC5/EYFP transgene with CK6/ECFP ES cells. The restricted fields of fluorescence represent the proliferative zones present within the pancreas. (d) liver from a double-tagged triple-compartment adult chimera. A non-fluorescent morula was aggregated with two clumps of ES cells, one carrying the CK6/ECFP transgene (ECFP+) and the other carrying the YC5/EYFP transgene (EYFP+). An ECFP+ vessel has clonally proliferated and infiltrated the liver lobe (top). Note that unlike in heart and pancreas there appears to be more interspersed blue/cyan vs green/yellow fluorescence present in the liver, possibly reflecting greater cell intermingling during the genesis of this organ."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T6267","span":{"begin":48,"end":54},"obj":"UBERON:0000062"},{"id":"T6268","span":{"begin":58,"end":63},"obj":"UBERON:0007023"},{"id":"T6269","span":{"begin":284,"end":289},"obj":"UBERON:0000948"},{"id":"T6270","span":{"begin":294,"end":302},"obj":"UBERON:0001264"},{"id":"T6271","span":{"begin":341,"end":346},"obj":"UBERON:0007023"},{"id":"T6272","span":{"begin":387,"end":392},"obj":"UBERON:0007023"},{"id":"T6273","span":{"begin":393,"end":398},"obj":"UBERON:0000948"},{"id":"T6274","span":{"begin":429,"end":441},"obj":"_FRAGMENT"},{"id":"T6275","span":{"begin":453,"end":458},"obj":"UBERON:0002082"},{"id":"T6276","span":{"begin":499,"end":506},"obj":"UBERON:0000085"},{"id":"T6277","span":{"begin":548,"end":557},"obj":"SO:0000902"},{"id":"T6278","span":{"begin":608,"end":617},"obj":"SO:0000902"},{"id":"T6279","span":{"begin":799,"end":808},"obj":"UBERON:0002082"},{"id":"T6280","span":{"begin":823,"end":831},"obj":"UBERON:0001264"},{"id":"T6281","span":{"begin":862,"end":868},"obj":"UBERON:0000085"},{"id":"T6282","span":{"begin":897,"end":906},"obj":"SO:0000902"},{"id":"T6283","span":{"begin":921,"end":929},"obj":"CL:0002322"},{"id":"T6284","span":{"begin":1022,"end":1030},"obj":"UBERON:0001264"},{"id":"T6285","span":{"begin":1036,"end":1041},"obj":"UBERON:0002107"},{"id":"T6286","span":{"begin":1082,"end":1087},"obj":"UBERON:0007023"},{"id":"T6287","span":{"begin":1115,"end":1121},"obj":"UBERON:0000085"},{"id":"T6288","span":{"begin":1156,"end":1164},"obj":"CL:0002322"},{"id":"T6289","span":{"begin":1192,"end":1201},"obj":"SO:0000902"},{"id":"T6290","span":{"begin":1246,"end":1255},"obj":"SO:0000902"},{"id":"T6291","span":{"begin":1274,"end":1280},"obj":"UBERON:0000055"},{"id":"T6292","span":{"begin":1294,"end":1306},"obj":"GO:0008283"},{"id":"T6293","span":{"begin":1327,"end":1337},"obj":"UBERON:0001113"},{"id":"T6294","span":{"begin":1365,"end":1370},"obj":"UBERON:0000948"},{"id":"T6295","span":{"begin":1375,"end":1383},"obj":"UBERON:0001264"},{"id":"T6296","span":{"begin":1476,"end":1481},"obj":"UBERON:0002107"},{"id":"T6297","span":{"begin":1541,"end":1551},"obj":"_FRAGMENT"},{"id":"T6298","span":{"begin":1557,"end":1562},"obj":"GO:0048513"},{"id":"T6299","span":{"begin":1557,"end":1562},"obj":"UBERON:0000062"}],"relations":[{"id":"R3702","pred":"_lexicallyChainedTo","subj":"T6275","obj":"T6274"},{"id":"R3703","pred":"_lexicallyChainedTo","subj":"T6298","obj":"T6297"}],"text":"Dual non-invasive reporter visualization in the organs of adult chimeras. All images depict dark field double exposures acquired by consecutively using ECFP and EYFP filters under dark field epifluorescence. Details of aggregates are schematized at the top right of each panel. (a-c) heart and pancreas from double-tagged double-compartment adult chimeras. (a) view of the surface of an adult heart. (b) close-up surface view of ventricle of a chimeric heart generated by aggregation of two diploid morulae, one hemizygous for the CK6/ECFP (ECFP+) transgene and the other hemizygous for the YC5/EYFP (EYFP+) transgene. The regions of yellow/green and cyan fluorescence are clearly mutually exclusive. The striations in the fields of fluorescence represent the proliferative zones present within the ventricle. (c) chimeric pancreas generated by aggregation of a morula hemizygous for the YC5/EYFP transgene with CK6/ECFP ES cells. The restricted fields of fluorescence represent the proliferative zones present within the pancreas. (d) liver from a double-tagged triple-compartment adult chimera. A non-fluorescent morula was aggregated with two clumps of ES cells, one carrying the CK6/ECFP transgene (ECFP+) and the other carrying the YC5/EYFP transgene (EYFP+). An ECFP+ vessel has clonally proliferated and infiltrated the liver lobe (top). Note that unlike in heart and pancreas there appears to be more interspersed blue/cyan vs green/yellow fluorescence present in the liver, possibly reflecting greater cell intermingling during the genesis of this organ."}