PMC:11492521 / 3683-4663 JSONTXT

{"project":"PubTator4TogoVar","denotations":[{"id":"65","span":{"begin":888,"end":897},"obj":"SNP"},{"id":"66","span":{"begin":902,"end":909},"obj":"SNP"}],"attributes":[{"id":"A65","pred":"resolved_to","subj":"65","obj":"tmVar:rs3212986;VariantGroup:0;CorrespondingGene:2067;RS#:3212986;CorrespondingSpecies:9606"},{"id":"A66","pred":"resolved_to","subj":"66","obj":"tmVar:rs11615;VariantGroup:2;CorrespondingGene:2067;RS#:11615;CorrespondingSpecies:9606"}],"text":" Genetic mutations within DNA repair genes can alter the expression, structure, and function of associated proteins, serving as important prognostic indicators for malignancies.1 Several studies suggest that the presence of certain functional polymorphisms within the ERCC1 gene may decrease DNA repair capabilities, thereby increasing the risk of various malignancies.11-14 Several other studies have also pointed to an association between ERCC1 variants and clinical outcomes in NSCLC patients.15,16 Regarding the carcinogenic potential of ERCC1 polymorphisms, these changes might serve as useful prognostic biomarkers in lung cancer. To the best of our knowledge, there is no report on the associations between polymorphisms of the ERCC1 gene and lung cancer in Iranian populations. Therefore, the current study has focused on the association of single-nucleotide polymorphisms (SNPs) rs3212986 and rs11615 within the ERCC1 gene with NSCLC in a southeastern Iranian population."}

{"project":"PubTatorOnTogoVar","denotations":[{"id":"65","span":{"begin":888,"end":897},"obj":"SNP"},{"id":"66","span":{"begin":902,"end":909},"obj":"SNP"},{"id":"T1","span":{"begin":888,"end":897},"obj":"SNP"},{"id":"T2","span":{"begin":902,"end":909},"obj":"SNP"}],"attributes":[{"id":"A65","pred":"resolved_to","subj":"65","obj":"tmVar:rs3212986;VariantGroup:0;CorrespondingGene:2067;RS#:3212986;CorrespondingSpecies:9606"},{"id":"A66","pred":"resolved_to","subj":"66","obj":"tmVar:rs11615;VariantGroup:2;CorrespondingGene:2067;RS#:11615;CorrespondingSpecies:9606"}],"text":" Genetic mutations within DNA repair genes can alter the expression, structure, and function of associated proteins, serving as important prognostic indicators for malignancies.1 Several studies suggest that the presence of certain functional polymorphisms within the ERCC1 gene may decrease DNA repair capabilities, thereby increasing the risk of various malignancies.11-14 Several other studies have also pointed to an association between ERCC1 variants and clinical outcomes in NSCLC patients.15,16 Regarding the carcinogenic potential of ERCC1 polymorphisms, these changes might serve as useful prognostic biomarkers in lung cancer. To the best of our knowledge, there is no report on the associations between polymorphisms of the ERCC1 gene and lung cancer in Iranian populations. Therefore, the current study has focused on the association of single-nucleotide polymorphisms (SNPs) rs3212986 and rs11615 within the ERCC1 gene with NSCLC in a southeastern Iranian population."}