PMC:1142324 / 482-892 JSONTXT

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    craft-sa-dev

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    craft-ca-core-ex-dev

    {"project":"craft-ca-core-ex-dev","denotations":[{"id":"T72","span":{"begin":0,"end":6},"obj":"PR_EXT:000003718"},{"id":"T73","span":{"begin":17,"end":21},"obj":"NCBITaxon:10088"},{"id":"T74","span":{"begin":105,"end":110},"obj":"GO:0007567"},{"id":"T75","span":{"begin":176,"end":180},"obj":"GO:0016265"},{"id":"T76","span":{"begin":283,"end":298},"obj":"UBERON:0000956"},{"id":"T77","span":{"begin":302,"end":312},"obj":"UBERON:0002037"},{"id":"T78","span":{"begin":331,"end":338},"obj":"SO_EXT:sequence_altered_entity"},{"id":"T79","span":{"begin":360,"end":371},"obj":"GO_EXT:myelin_assembly_or_myelination"},{"id":"T80","span":{"begin":379,"end":396},"obj":"UBERON:0001021"}],"text":"ADAM22-deficient mice were produced in a good accordance with the Mendelian ratio and appeared normal at birth. After one week, severe ataxia was observed, and all homozygotes died before weaning, probably due to convulsions. No major histological abnormalities were detected in the cerebral cortex or cerebellum of the homozygous mutants; however, marked hypomyelination of the peripheral nerves was observed."}

    craft-ca-core-dev

    {"project":"craft-ca-core-dev","denotations":[{"id":"T40","span":{"begin":0,"end":6},"obj":"PR:000003718"},{"id":"T41","span":{"begin":17,"end":21},"obj":"NCBITaxon:10088"},{"id":"T42","span":{"begin":105,"end":110},"obj":"GO:0007567"},{"id":"T43","span":{"begin":176,"end":180},"obj":"GO:0016265"},{"id":"T44","span":{"begin":283,"end":298},"obj":"UBERON:0000956"},{"id":"T45","span":{"begin":302,"end":312},"obj":"UBERON:0002037"},{"id":"T46","span":{"begin":379,"end":396},"obj":"UBERON:0001021"}],"text":"ADAM22-deficient mice were produced in a good accordance with the Mendelian ratio and appeared normal at birth. After one week, severe ataxia was observed, and all homozygotes died before weaning, probably due to convulsions. No major histological abnormalities were detected in the cerebral cortex or cerebellum of the homozygous mutants; however, marked hypomyelination of the peripheral nerves was observed."}