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PMC:1142324 / 11670-13636 JSONTXT

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Id Subject Object Predicate Lexical cue
T3705 0-2 IN denotes In
T3706 25-33 VBD denotes examined
T3707 3-6 DT denotes the
T3708 15-20 NN denotes study
T3709 7-14 JJ denotes present
T3710 20-22 , denotes ,
T3711 22-24 PRP denotes we
T3712 34-37 DT denotes the
T3713 38-46 NN denotes function
T3714 47-49 IN denotes of
T3715 50-56 NN denotes ADAM22
T3716 57-59 IN denotes by
T3717 60-70 VBG denotes generating
T3718 71-75 NNS denotes mice
T3719 76-80 WDT denotes that
T3720 81-87 VBD denotes lacked
T3721 88-91 DT denotes the
T3722 99-103 NN denotes gene
T3723 92-98 NN denotes Adam22
T3724 103-104 . denotes .
T3725 104-171 sentence denotes ADAM22-deficient mice exhibited severe ataxia and premature death.
T3726 105-111 NN denotes ADAM22
T3727 112-121 JJ denotes deficient
T3728 111-112 HYPH denotes -
T3729 122-126 NNS denotes mice
T3730 127-136 VBD denotes exhibited
T3731 137-143 JJ denotes severe
T3732 144-150 NN denotes ataxia
T3733 151-154 CC denotes and
T3734 155-164 JJ denotes premature
T3735 165-170 NN denotes death
T3736 170-171 . denotes .
T3737 171-288 sentence denotes In contrast, heterozygous mutants were healthy, fertile and survived more than 1 year without obvious abnormalities.
T3738 172-174 IN denotes In
T3739 206-210 VBD denotes were
T3740 175-183 NN denotes contrast
T3741 183-185 , denotes ,
T3742 185-197 JJ denotes heterozygous
T3743 198-205 NNS denotes mutants
T3744 211-218 JJ denotes healthy
T3745 220-227 JJ denotes fertile
T3746 218-220 , denotes ,
T3747 228-231 CC denotes and
T3748 232-240 VBD denotes survived
T3749 241-245 JJR denotes more
T3750 251-252 CD denotes 1
T3751 246-250 IN denotes than
T3752 253-257 NN denotes year
T3753 258-265 IN denotes without
T3754 266-273 JJ denotes obvious
T3755 274-287 NNS denotes abnormalities
T3756 287-288 . denotes .
T3757 288-401 sentence denotes The cause of death in the homozygous mutants is not clear; however, it is likely to be due to multiple seizures.
T3758 289-292 DT denotes The
T3759 293-298 NN denotes cause
T3760 334-336 VBZ denotes is
T3761 299-301 IN denotes of
T3762 302-307 NN denotes death
T3763 308-310 IN denotes in
T3764 311-314 DT denotes the
T3765 326-333 NNS denotes mutants
T3766 315-325 JJ denotes homozygous
T3767 360-362 VBZ denotes is
T3768 337-340 RB denotes not
T3769 341-346 JJ denotes clear
T3770 346-347 : denotes ;
T3771 348-355 RB denotes however
T3772 355-357 , denotes ,
T3773 357-359 PRP denotes it
T3774 363-369 JJ denotes likely
T3775 370-372 TO denotes to
T3776 373-375 VB denotes be
T3777 376-379 IN denotes due
T3778 380-382 IN denotes to
T3779 383-391 JJ denotes multiple
T3780 392-400 NNS denotes seizures
T3781 400-401 . denotes .
T3782 401-571 sentence denotes This is because convulsive seizures were occasionally observed in homozygotes, after which the suffered mice appeared exhausted and, in most cases, died on the next day.
T3783 402-406 DT denotes This
T3784 407-409 VBZ denotes is
T3785 410-417 IN denotes because
T3786 456-464 VBN denotes observed
T3787 418-428 JJ denotes convulsive
T3788 429-437 NNS denotes seizures
T3789 438-442 VBD denotes were
T3790 443-455 RB denotes occasionally
T3791 465-467 IN denotes in
T3792 468-479 NNS denotes homozygotes
T3793 479-481 , denotes ,
T3794 481-486 IN denotes after
T3795 511-519 VBD denotes appeared
T3796 487-492 WDT denotes which
T3797 493-496 DT denotes the
T3798 506-510 NNS denotes mice
T3799 497-505 VBN denotes suffered
T3800 520-529 JJ denotes exhausted
T3801 530-533 CC denotes and
T3802 533-535 , denotes ,
T3803 535-537 IN denotes in
T3804 550-554 VBD denotes died
T3805 538-542 JJS denotes most
T3806 543-548 NNS denotes cases
T3807 548-550 , denotes ,
T3808 555-557 IN denotes on
T3809 558-561 DT denotes the
T3810 567-570 NN denotes day
T3811 562-566 JJ denotes next
T3812 570-571 . denotes .
T3813 571-679 sentence denotes It is known that cortical dysplasia resulting from aberrant brain development causes seizure syndrome [22].
T3814 572-574 PRP denotes It
T3815 578-583 VBN denotes known
T3816 575-577 VBZ denotes is
T3817 584-588 IN denotes that
T3818 650-656 VBZ denotes causes
T3819 589-597 JJ denotes cortical
T3820 598-607 NN denotes dysplasia
T3821 608-617 VBG denotes resulting
T3822 618-622 IN denotes from
T3823 623-631 JJ denotes aberrant
T3824 638-649 NN denotes development
T3825 632-637 NN denotes brain
T3826 657-664 NN denotes seizure
T3827 665-673 NN denotes syndrome
T3828 674-675 -LRB- denotes [
T3829 675-677 CD denotes 22
T3830 677-678 -RRB- denotes ]
T3831 678-679 . denotes .
T3832 679-815 sentence denotes For example, mice lacking the neuron-specific activator of cyclin 5, p35, exhibit seizures and a severe neuronal migration defect [23].
T3833 680-683 IN denotes For
T3834 754-761 VBP denotes exhibit
T3835 684-691 NN denotes example
T3836 691-693 , denotes ,
T3837 693-697 NNS denotes mice
T3838 698-705 VBG denotes lacking
T3839 706-709 DT denotes the
T3840 726-735 NN denotes activator
T3841 710-716 NN denotes neuron
T3842 717-725 JJ denotes specific
T3843 716-717 HYPH denotes -
T3844 736-738 IN denotes of
T3845 739-745 NN denotes cyclin
T3846 746-747 CD denotes 5
T3847 747-749 , denotes ,
T3848 749-752 NN denotes p35
T3849 752-754 , denotes ,
T3850 762-770 NNS denotes seizures
T3851 771-774 CC denotes and
T3852 775-776 DT denotes a
T3853 803-809 NN denotes defect
T3854 777-783 JJ denotes severe
T3855 784-792 JJ denotes neuronal
T3856 793-802 NN denotes migration
T3857 810-811 -LRB- denotes [
T3858 811-813 CD denotes 23
T3859 813-814 -RRB- denotes ]
T3860 814-815 . denotes .
T3861 815-1027 sentence denotes Because ADAM22 protein is expressed on the cell surface and is likely to be involved in cell-cell or cell-matrix interactions, we hypothesized that depletion of ADAM22 would generate aberrant neuronal migration.
T3862 816-823 IN denotes Because
T3863 842-851 VBN denotes expressed
T3864 824-830 NN denotes ADAM22
T3865 831-838 NN denotes protein
T3866 839-841 VBZ denotes is
T3867 946-958 VBD denotes hypothesized
T3868 852-854 IN denotes on
T3869 855-858 DT denotes the
T3870 864-871 NN denotes surface
T3871 859-863 NN denotes cell
T3872 872-875 CC denotes and
T3873 876-878 VBZ denotes is
T3874 879-885 JJ denotes likely
T3875 886-888 TO denotes to
T3876 892-900 VBN denotes involved
T3877 889-891 VB denotes be
T3878 901-903 IN denotes in
T3879 904-908 NN denotes cell
T3880 909-913 NN denotes cell
T3881 908-909 HYPH denotes -
T3882 929-941 NNS denotes interactions
T3883 914-916 CC denotes or
T3884 917-921 NN denotes cell
T3885 922-928 NN denotes matrix
T3886 921-922 HYPH denotes -
T3887 941-943 , denotes ,
T3888 943-945 PRP denotes we
T3889 959-963 IN denotes that
T3890 990-998 VB denotes generate
T3891 964-973 NN denotes depletion
T3892 974-976 IN denotes of
T3893 977-983 NN denotes ADAM22
T3894 984-989 MD denotes would
T3895 999-1007 JJ denotes aberrant
T3896 1017-1026 NN denotes migration
T3897 1008-1016 JJ denotes neuronal
T3898 1026-1027 . denotes .
T3899 1027-1091 sentence denotes Histochemical analysis was performed to verify this hypothesis.
T3900 1028-1041 JJ denotes Histochemical
T3901 1042-1050 NN denotes analysis
T3902 1055-1064 VBN denotes performed
T3903 1051-1054 VBD denotes was
T3904 1065-1067 TO denotes to
T3905 1068-1074 VB denotes verify
T3906 1075-1079 DT denotes this
T3907 1080-1090 NN denotes hypothesis
T3908 1090-1091 . denotes .
T3909 1091-1226 sentence denotes However, no marked abnormalities were observed in the mutant mouse brain, ruling out a critical role for ADAM22 in neuronal migration.
T3910 1092-1099 RB denotes However
T3911 1130-1138 VBN denotes observed
T3912 1099-1101 , denotes ,
T3913 1101-1103 DT denotes no
T3914 1111-1124 NNS denotes abnormalities
T3915 1104-1110 JJ denotes marked
T3916 1125-1129 VBD denotes were
T3917 1139-1141 IN denotes in
T3918 1142-1145 DT denotes the
T3919 1159-1164 NN denotes brain
T3920 1146-1152 NN denotes mutant
T3921 1153-1158 NN denotes mouse
T3922 1164-1166 , denotes ,
T3923 1166-1172 VBG denotes ruling
T3924 1173-1176 RP denotes out
T3925 1177-1178 DT denotes a
T3926 1188-1192 NN denotes role
T3927 1179-1187 JJ denotes critical
T3928 1193-1196 IN denotes for
T3929 1197-1203 NN denotes ADAM22
T3930 1204-1206 IN denotes in
T3931 1207-1215 JJ denotes neuronal
T3932 1216-1225 NN denotes migration
T3933 1225-1226 . denotes .
T3934 1226-1370 sentence denotes Another possible explanation is that the premature death in first 2 weeks of life is caused by the dysfunction of the autonomic nervous system.
T3935 1227-1234 DT denotes Another
T3936 1244-1255 NN denotes explanation
T3937 1235-1243 JJ denotes possible
T3938 1256-1258 VBZ denotes is
T3939 1259-1263 IN denotes that
T3940 1312-1318 VBN denotes caused
T3941 1264-1267 DT denotes the
T3942 1278-1283 NN denotes death
T3943 1268-1277 JJ denotes premature
T3944 1284-1286 IN denotes in
T3945 1287-1292 JJ denotes first
T3946 1295-1300 NNS denotes weeks
T3947 1293-1294 CD denotes 2
T3948 1301-1303 IN denotes of
T3949 1304-1308 NN denotes life
T3950 1309-1311 VBZ denotes is
T3951 1319-1321 IN denotes by
T3952 1322-1325 DT denotes the
T3953 1326-1337 NN denotes dysfunction
T3954 1338-1340 IN denotes of
T3955 1341-1344 DT denotes the
T3956 1363-1369 NN denotes system
T3957 1345-1354 JJ denotes autonomic
T3958 1355-1362 JJ denotes nervous
T3959 1369-1370 . denotes .
T3960 1370-1542 sentence denotes Especially, nerves which control the breathing would be very important, because the respiration system undergoes significant maturation in the first 2–3 weeks after birth.
T3961 1371-1381 RB denotes Especially
T3962 1424-1426 VB denotes be
T3963 1381-1383 , denotes ,
T3964 1383-1389 NNS denotes nerves
T3965 1390-1395 WDT denotes which
T3966 1396-1403 VBP denotes control
T3967 1404-1407 DT denotes the
T3968 1408-1417 NN denotes breathing
T3969 1418-1423 MD denotes would
T3970 1427-1431 RB denotes very
T3971 1432-1441 JJ denotes important
T3972 1441-1443 , denotes ,
T3973 1443-1450 IN denotes because
T3974 1474-1483 VBZ denotes undergoes
T3975 1451-1454 DT denotes the
T3976 1467-1473 NN denotes system
T3977 1455-1466 NN denotes respiration
T3978 1484-1495 JJ denotes significant
T3979 1496-1506 NN denotes maturation
T3980 1507-1509 IN denotes in
T3981 1510-1513 DT denotes the
T3982 1524-1529 NNS denotes weeks
T3983 1514-1519 JJ denotes first
T3984 1520-1521 CD denotes 2
T3985 1522-1523 CD denotes 3
T3986 1521-1522 SYM denotes –
T3987 1530-1535 IN denotes after
T3988 1536-1541 NN denotes birth
T3989 1541-1542 . denotes .
T3990 1542-1740 sentence denotes For example, the myelin-deficient (MD) rat, which carries a point mutation in the proteolipid protein (PLP) gene, exhibits ataxia, tremor, dysmyelination and dies at approximately postnatal day 21.
T3991 1543-1546 IN denotes For
T3992 1657-1665 VBZ denotes exhibits
T3993 1547-1554 NN denotes example
T3994 1554-1556 , denotes ,
T3995 1556-1559 DT denotes the
T3996 1582-1585 NN denotes rat
T3997 1560-1566 NN denotes myelin
T3998 1567-1576 JJ denotes deficient
T3999 1566-1567 HYPH denotes -
T4000 1577-1578 -LRB- denotes (
T4001 1578-1580 JJ denotes MD
T4002 1580-1581 -RRB- denotes )
T4003 1585-1587 , denotes ,
T4004 1587-1592 WDT denotes which
T4005 1593-1600 VBZ denotes carries
T4006 1601-1602 DT denotes a
T4007 1609-1617 NN denotes mutation
T4008 1603-1608 NN denotes point
T4009 1618-1620 IN denotes in
T4010 1621-1624 DT denotes the
T4011 1651-1655 NN denotes gene
T4012 1625-1636 NN denotes proteolipid
T4013 1637-1644 NN denotes protein
T4014 1645-1646 -LRB- denotes (
T4015 1646-1649 NN denotes PLP
T4016 1649-1650 -RRB- denotes )
T4017 1655-1657 , denotes ,
T4018 1666-1672 NN denotes ataxia
T4019 1682-1696 NN denotes dysmyelination
T4020 1672-1674 , denotes ,
T4021 1674-1680 NN denotes tremor
T4022 1680-1682 , denotes ,
T4023 1697-1700 CC denotes and
T4024 1701-1705 VBZ denotes dies
T4025 1706-1708 IN denotes at
T4026 1709-1722 RB denotes approximately
T4027 1733-1736 NN denotes day
T4028 1723-1732 JJ denotes postnatal
T4029 1737-1739 CD denotes 21
T4030 1739-1740 . denotes .
T4031 1740-1887 sentence denotes In MD rat, early death is caused by the dysfunction of the brain stem which is essential for autonomic control of respiration during hypoxia [24].
T4032 1741-1743 IN denotes In
T4033 1767-1773 VBN denotes caused
T4034 1744-1746 NN denotes MD
T4035 1747-1750 NN denotes rat
T4036 1750-1752 , denotes ,
T4037 1752-1757 JJ denotes early
T4038 1758-1763 NN denotes death
T4039 1764-1766 VBZ denotes is
T4040 1774-1776 IN denotes by
T4041 1777-1780 DT denotes the
T4042 1781-1792 NN denotes dysfunction
T4043 1793-1795 IN denotes of
T4044 1796-1799 DT denotes the
T4045 1806-1810 NN denotes stem
T4046 1800-1805 NN denotes brain
T4047 1811-1816 WDT denotes which
T4048 1817-1819 VBZ denotes is
T4049 1820-1829 JJ denotes essential
T4050 1830-1833 IN denotes for
T4051 1834-1843 JJ denotes autonomic
T4052 1844-1851 NN denotes control
T4053 1852-1854 IN denotes of
T4054 1855-1866 NN denotes respiration
T4055 1867-1873 IN denotes during
T4056 1874-1881 NN denotes hypoxia
T4057 1882-1883 -LRB- denotes [
T4058 1883-1885 CD denotes 24
T4059 1885-1886 -RRB- denotes ]
T4060 1886-1887 . denotes .
T4061 1887-1966 sentence denotes Further study is needed to verify the cause of death in ADAM22-deficient mice.
T4062 1888-1895 JJ denotes Further
T4063 1896-1901 NN denotes study
T4064 1905-1911 VBN denotes needed
T4065 1902-1904 VBZ denotes is
T4066 1912-1914 TO denotes to
T4067 1915-1921 VB denotes verify
T4068 1922-1925 DT denotes the
T4069 1926-1931 NN denotes cause
T4070 1932-1934 IN denotes of
T4071 1935-1940 NN denotes death
T4072 1941-1943 IN denotes in
T4073 1944-1950 NN denotes ADAM22
T4074 1951-1960 JJ denotes deficient
T4075 1950-1951 HYPH denotes -
T4076 1961-1965 NNS denotes mice
T4077 1965-1966 . denotes .
R2119 T3705 T3706 prep In,examined
R2120 T3707 T3708 det the,study
R2121 T3708 T3705 pobj study,In
R2122 T3709 T3708 amod present,study
R2123 T3710 T3706 punct ", ",examined
R2124 T3711 T3706 nsubj we,examined
R2125 T3712 T3713 det the,function
R2126 T3713 T3706 dobj function,examined
R2127 T3714 T3713 prep of,function
R2128 T3715 T3714 pobj ADAM22,of
R2129 T3716 T3706 prep by,examined
R2130 T3717 T3716 pcomp generating,by
R2131 T3718 T3717 dobj mice,generating
R2132 T3719 T3720 dep that,lacked
R2133 T3720 T3718 relcl lacked,mice
R2134 T3721 T3722 det the,gene
R2135 T3722 T3720 dobj gene,lacked
R2136 T3723 T3722 compound Adam22,gene
R2137 T3724 T3706 punct .,examined
R2138 T3726 T3727 npadvmod ADAM22,deficient
R2139 T3727 T3729 amod deficient,mice
R2140 T3728 T3727 punct -,deficient
R2141 T3729 T3730 nsubj mice,exhibited
R2142 T3731 T3732 amod severe,ataxia
R2143 T3732 T3730 dobj ataxia,exhibited
R2144 T3733 T3732 cc and,ataxia
R2145 T3734 T3735 amod premature,death
R2146 T3735 T3732 conj death,ataxia
R2147 T3736 T3730 punct .,exhibited
R2148 T3738 T3739 prep In,were
R2149 T3740 T3738 pobj contrast,In
R2150 T3741 T3739 punct ", ",were
R2151 T3742 T3743 amod heterozygous,mutants
R2152 T3743 T3739 nsubj mutants,were
R2153 T3744 T3745 amod healthy,fertile
R2154 T3745 T3739 acomp fertile,were
R2155 T3746 T3745 punct ", ",fertile
R2156 T3747 T3739 cc and,were
R2157 T3748 T3739 conj survived,were
R2158 T3749 T3750 amod more,1
R2159 T3750 T3752 nummod 1,year
R2160 T3751 T3750 quantmod than,1
R2161 T3752 T3748 npadvmod year,survived
R2162 T3753 T3748 prep without,survived
R2163 T3754 T3755 amod obvious,abnormalities
R2164 T3755 T3753 pobj abnormalities,without
R2165 T3756 T3739 punct .,were
R2166 T3758 T3759 det The,cause
R2167 T3759 T3760 nsubj cause,is
R2168 T3760 T3767 ccomp is,is
R2169 T3761 T3759 prep of,cause
R2170 T3762 T3761 pobj death,of
R2171 T3763 T3759 prep in,cause
R2172 T3764 T3765 det the,mutants
R2173 T3765 T3763 pobj mutants,in
R2174 T3766 T3765 amod homozygous,mutants
R2175 T3768 T3760 neg not,is
R2176 T3769 T3760 acomp clear,is
R2177 T3770 T3767 punct ;,is
R2178 T3771 T3767 advmod however,is
R2179 T3772 T3767 punct ", ",is
R2180 T3773 T3767 nsubj it,is
R2181 T3774 T3767 acomp likely,is
R2182 T3775 T3776 aux to,be
R2183 T3776 T3774 xcomp be,likely
R2184 T3777 T3776 prep due,be
R2185 T3778 T3777 pcomp to,due
R2186 T3779 T3780 amod multiple,seizures
R2187 T3780 T3777 pobj seizures,due
R2188 T3781 T3767 punct .,is
R2189 T3783 T3784 nsubj This,is
R2190 T3785 T3786 mark because,observed
R2191 T3786 T3784 advcl observed,is
R2192 T3787 T3788 amod convulsive,seizures
R2193 T3788 T3786 nsubjpass seizures,observed
R2194 T3789 T3786 auxpass were,observed
R2195 T3790 T3786 advmod occasionally,observed
R2196 T3791 T3786 prep in,observed
R2197 T3792 T3791 pobj homozygotes,in
R2198 T3793 T3786 punct ", ",observed
R2199 T3794 T3795 prep after,appeared
R2200 T3795 T3786 advcl appeared,observed
R2201 T3796 T3794 pobj which,after
R2202 T3797 T3798 det the,mice
R2203 T3798 T3795 nsubj mice,appeared
R2204 T3799 T3798 amod suffered,mice
R2205 T3800 T3795 oprd exhausted,appeared
R2206 T3801 T3795 cc and,appeared
R2207 T3802 T3795 punct ", ",appeared
R2208 T3803 T3804 prep in,died
R2209 T3804 T3795 conj died,appeared
R2210 T3805 T3806 amod most,cases
R2211 T3806 T3803 pobj cases,in
R2212 T3807 T3804 punct ", ",died
R2213 T3808 T3804 prep on,died
R2214 T3809 T3810 det the,day
R2215 T3810 T3808 pobj day,on
R2216 T3811 T3810 amod next,day
R2217 T3812 T3784 punct .,is
R2218 T3814 T3815 nsubjpass It,known
R2219 T3816 T3815 auxpass is,known
R2220 T3817 T3818 mark that,causes
R2221 T3818 T3815 ccomp causes,known
R2222 T3819 T3820 amod cortical,dysplasia
R2223 T3820 T3818 nsubj dysplasia,causes
R2224 T3821 T3820 acl resulting,dysplasia
R2225 T3822 T3821 prep from,resulting
R2226 T3823 T3824 amod aberrant,development
R2227 T3824 T3822 pobj development,from
R2228 T3825 T3824 compound brain,development
R2229 T3826 T3827 compound seizure,syndrome
R2230 T3827 T3818 dobj syndrome,causes
R2231 T3828 T3829 punct [,22
R2232 T3829 T3815 parataxis 22,known
R2233 T3830 T3829 punct ],22
R2234 T3831 T3815 punct .,known
R2235 T3833 T3834 prep For,exhibit
R2236 T3835 T3833 pobj example,For
R2237 T3836 T3834 punct ", ",exhibit
R2238 T3837 T3834 nsubj mice,exhibit
R2239 T3838 T3837 acl lacking,mice
R2240 T3839 T3840 det the,activator
R2241 T3840 T3838 dobj activator,lacking
R2242 T3841 T3842 npadvmod neuron,specific
R2243 T3842 T3840 amod specific,activator
R2244 T3843 T3842 punct -,specific
R2245 T3844 T3840 prep of,activator
R2246 T3845 T3844 pobj cyclin,of
R2247 T3846 T3845 nummod 5,cyclin
R2248 T3847 T3840 punct ", ",activator
R2249 T3848 T3840 appos p35,activator
R2250 T3849 T3834 punct ", ",exhibit
R2251 T3850 T3834 dobj seizures,exhibit
R2252 T3851 T3850 cc and,seizures
R2253 T3852 T3853 det a,defect
R2254 T3853 T3850 conj defect,seizures
R2255 T3854 T3853 amod severe,defect
R2256 T3855 T3853 amod neuronal,defect
R2257 T3856 T3853 compound migration,defect
R2258 T3857 T3858 punct [,23
R2259 T3858 T3834 parataxis 23,exhibit
R2260 T3859 T3858 punct ],23
R2261 T3860 T3834 punct .,exhibit
R2262 T3862 T3863 mark Because,expressed
R2263 T3863 T3867 advcl expressed,hypothesized
R2264 T3864 T3865 compound ADAM22,protein
R2265 T3865 T3863 nsubjpass protein,expressed
R2266 T3866 T3863 auxpass is,expressed
R2267 T3868 T3863 prep on,expressed
R2268 T3869 T3870 det the,surface
R2269 T3870 T3868 pobj surface,on
R2270 T3871 T3870 compound cell,surface
R2271 T3872 T3863 cc and,expressed
R2272 T3873 T3863 conj is,expressed
R2273 T3874 T3873 acomp likely,is
R2274 T3875 T3876 aux to,involved
R2275 T3876 T3874 xcomp involved,likely
R2276 T3877 T3876 auxpass be,involved
R2277 T3878 T3876 prep in,involved
R2278 T3879 T3880 nmod cell,cell
R2279 T3880 T3882 nmod cell,interactions
R2280 T3881 T3880 punct -,cell
R2281 T3882 T3878 pobj interactions,in
R2282 T3883 T3880 cc or,cell
R2283 T3884 T3885 compound cell,matrix
R2284 T3885 T3880 conj matrix,cell
R2285 T3886 T3885 punct -,matrix
R2286 T3887 T3867 punct ", ",hypothesized
R2287 T3888 T3867 nsubj we,hypothesized
R2288 T3889 T3890 mark that,generate
R2289 T3890 T3867 ccomp generate,hypothesized
R2290 T3891 T3890 nsubj depletion,generate
R2291 T3892 T3891 prep of,depletion
R2292 T3893 T3892 pobj ADAM22,of
R2293 T3894 T3890 aux would,generate
R2294 T3895 T3896 amod aberrant,migration
R2295 T3896 T3890 dobj migration,generate
R2296 T3897 T3896 amod neuronal,migration
R2297 T3898 T3867 punct .,hypothesized
R2298 T3900 T3901 amod Histochemical,analysis
R2299 T3901 T3902 nsubjpass analysis,performed
R2300 T3903 T3902 auxpass was,performed
R2301 T3904 T3905 aux to,verify
R2302 T3905 T3902 advcl verify,performed
R2303 T3906 T3907 det this,hypothesis
R2304 T3907 T3905 dobj hypothesis,verify
R2305 T3908 T3902 punct .,performed
R2306 T3910 T3911 advmod However,observed
R2307 T3912 T3911 punct ", ",observed
R2308 T3913 T3914 det no,abnormalities
R2309 T3914 T3911 nsubjpass abnormalities,observed
R2310 T3915 T3914 amod marked,abnormalities
R2311 T3916 T3911 auxpass were,observed
R2312 T3917 T3911 prep in,observed
R2313 T3918 T3919 det the,brain
R2314 T3919 T3917 pobj brain,in
R2315 T3920 T3919 compound mutant,brain
R2316 T3921 T3919 compound mouse,brain
R2317 T3922 T3911 punct ", ",observed
R2318 T3923 T3911 advcl ruling,observed
R2319 T3924 T3923 prt out,ruling
R2320 T3925 T3926 det a,role
R2321 T3926 T3923 dobj role,ruling
R2322 T3927 T3926 amod critical,role
R2323 T3928 T3926 prep for,role
R2324 T3929 T3928 pobj ADAM22,for
R2325 T3930 T3926 prep in,role
R2326 T3931 T3932 amod neuronal,migration
R2327 T3932 T3930 pobj migration,in
R2328 T3933 T3911 punct .,observed
R2329 T3935 T3936 det Another,explanation
R2330 T3936 T3938 nsubj explanation,is
R2331 T3937 T3936 amod possible,explanation
R2332 T3939 T3940 mark that,caused
R2333 T3940 T3938 ccomp caused,is
R2334 T3941 T3942 det the,death
R2335 T3942 T3940 nsubjpass death,caused
R2336 T3943 T3942 amod premature,death
R2337 T3944 T3942 prep in,death
R2338 T3945 T3946 amod first,weeks
R2339 T3946 T3944 pobj weeks,in
R2340 T3947 T3946 nummod 2,weeks
R2341 T3948 T3946 prep of,weeks
R2342 T3949 T3948 pobj life,of
R2343 T3950 T3940 auxpass is,caused
R2344 T3951 T3940 agent by,caused
R2345 T3952 T3953 det the,dysfunction
R2346 T3953 T3951 pobj dysfunction,by
R2347 T3954 T3953 prep of,dysfunction
R2348 T3955 T3956 det the,system
R2349 T3956 T3954 pobj system,of
R2350 T3957 T3956 amod autonomic,system
R2351 T3958 T3956 amod nervous,system
R2352 T3959 T3938 punct .,is
R2353 T3961 T3962 advmod Especially,be
R2354 T3963 T3962 punct ", ",be
R2355 T3964 T3962 nsubj nerves,be
R2356 T3965 T3966 dep which,control
R2357 T3966 T3964 relcl control,nerves
R2358 T3967 T3968 det the,breathing
R2359 T3968 T3966 dobj breathing,control
R2360 T3969 T3962 aux would,be
R2361 T3970 T3971 advmod very,important
R2362 T3971 T3962 acomp important,be
R2363 T3972 T3962 punct ", ",be
R2364 T3973 T3974 mark because,undergoes
R2365 T3974 T3962 advcl undergoes,be
R2366 T3975 T3976 det the,system
R2367 T3976 T3974 nsubj system,undergoes
R2368 T3977 T3976 compound respiration,system
R2369 T3978 T3979 amod significant,maturation
R2370 T3979 T3974 dobj maturation,undergoes
R2371 T3980 T3974 prep in,undergoes
R2372 T3981 T3982 det the,weeks
R2373 T3982 T3980 pobj weeks,in
R2374 T3983 T3982 amod first,weeks
R2375 T3984 T3985 quantmod 2,3
R2376 T3985 T3982 nummod 3,weeks
R2377 T3986 T3985 punct –,3
R2378 T3987 T3982 prep after,weeks
R2379 T3988 T3987 pobj birth,after
R2380 T3989 T3962 punct .,be
R2381 T3991 T3992 prep For,exhibits
R2382 T3993 T3991 pobj example,For
R2383 T3994 T3992 punct ", ",exhibits
R2384 T3995 T3996 det the,rat
R2385 T3996 T3992 nsubj rat,exhibits
R2386 T3997 T3998 npadvmod myelin,deficient
R2387 T3998 T3996 amod deficient,rat
R2388 T3999 T3998 punct -,deficient
R2389 T4000 T4001 punct (,MD
R2390 T4001 T3998 parataxis MD,deficient
R2391 T4002 T4001 punct ),MD
R2392 T4003 T3996 punct ", ",rat
R2393 T4004 T4005 dep which,carries
R2394 T4005 T3996 relcl carries,rat
R2395 T4006 T4007 det a,mutation
R2396 T4007 T4005 dobj mutation,carries
R2397 T4008 T4007 compound point,mutation
R2398 T4009 T4005 prep in,carries
R2399 T4010 T4011 det the,gene
R2400 T4011 T4009 pobj gene,in
R2401 T4012 T4013 nmod proteolipid,protein
R2402 T4013 T4011 nmod protein,gene
R2403 T4014 T4013 punct (,protein
R2404 T4015 T4013 appos PLP,protein
R2405 T4016 T4011 punct ),gene
R2406 T4017 T3992 punct ", ",exhibits
R2407 T4018 T4019 nmod ataxia,dysmyelination
R2408 T4019 T3992 dobj dysmyelination,exhibits
R2409 T4020 T4019 punct ", ",dysmyelination
R2410 T4021 T4019 nmod tremor,dysmyelination
R2411 T4022 T4019 punct ", ",dysmyelination
R2412 T4023 T3992 cc and,exhibits
R2413 T4024 T3992 conj dies,exhibits
R2414 T4025 T4024 prep at,dies
R2415 T4026 T4027 advmod approximately,day
R2416 T4027 T4025 pobj day,at
R2417 T4028 T4027 amod postnatal,day
R2418 T4029 T4027 nummod 21,day
R2419 T4030 T3992 punct .,exhibits
R2420 T4032 T4033 prep In,caused
R2421 T4034 T4035 compound MD,rat
R2422 T4035 T4032 pobj rat,In
R2423 T4036 T4033 punct ", ",caused
R2424 T4037 T4038 amod early,death
R2425 T4038 T4033 nsubjpass death,caused
R2426 T4039 T4033 auxpass is,caused
R2427 T4040 T4033 agent by,caused
R2428 T4041 T4042 det the,dysfunction
R2429 T4042 T4040 pobj dysfunction,by
R2430 T4043 T4042 prep of,dysfunction
R2431 T4044 T4045 det the,stem
R2432 T4045 T4043 pobj stem,of
R2433 T4046 T4045 compound brain,stem
R2434 T4047 T4048 dep which,is
R2435 T4048 T4045 relcl is,stem
R2436 T4049 T4048 acomp essential,is
R2437 T4050 T4049 prep for,essential
R2438 T4051 T4052 amod autonomic,control
R2439 T4052 T4050 pobj control,for
R2440 T4053 T4052 prep of,control
R2441 T4054 T4053 pobj respiration,of
R2442 T4055 T4052 prep during,control
R2443 T4056 T4055 pobj hypoxia,during
R2444 T4057 T4058 punct [,24
R2445 T4058 T4033 parataxis 24,caused
R2446 T4059 T4058 punct ],24
R2447 T4060 T4033 punct .,caused
R2448 T4062 T4063 amod Further,study
R2449 T4063 T4064 nsubjpass study,needed
R2450 T4065 T4064 auxpass is,needed
R2451 T4066 T4067 aux to,verify
R2452 T4067 T4064 advcl verify,needed
R2453 T4068 T4069 det the,cause
R2454 T4069 T4067 dobj cause,verify
R2455 T4070 T4069 prep of,cause
R2456 T4071 T4070 pobj death,of
R2457 T4072 T4069 prep in,cause
R2458 T4073 T4074 npadvmod ADAM22,deficient
R2459 T4074 T4076 amod deficient,mice
R2460 T4075 T4074 punct -,deficient
R2461 T4076 T4072 pobj mice,in
R2462 T4077 T4064 punct .,needed

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T3559 50-56 PR_EXT:000003718 denotes ADAM22
T3560 71-75 NCBITaxon:10088 denotes mice
T3561 92-98 PR_EXT:000003718 denotes Adam22
T3562 99-103 SO_EXT:0000704 denotes gene
T3563 105-111 PR_EXT:000003718 denotes ADAM22
T3564 122-126 NCBITaxon:10088 denotes mice
T3565 165-170 GO:0016265 denotes death
T3566 198-205 SO_EXT:sequence_altered_entity denotes mutants
T3567 302-307 GO:0016265 denotes death
T3568 326-333 SO_EXT:sequence_altered_entity denotes mutants
T3569 506-510 NCBITaxon:10088 denotes mice
T3570 550-554 GO:0016265 denotes died
T3571 589-597 UBERON:0001851 denotes cortical
T3572 632-637 UBERON:0000955 denotes brain
T3573 632-649 GO:0007420 denotes brain development
T3574 693-697 NCBITaxon:10088 denotes mice
T3575 710-716 CL:0000540 denotes neuron
T3576 726-747 PR_EXT:000005259 denotes activator of cyclin 5
T3577 749-752 PR_EXT:000005259 denotes p35
T3578 784-792 CL:0000540 denotes neuronal
T3579 784-802 GO:0001764 denotes neuronal migration
T3580 824-830 PR_EXT:000003718 denotes ADAM22
T3581 831-838 CHEBI_PR_EXT:protein denotes protein
T3582 842-851 GO:0010467 denotes expressed
T3583 859-863 CL_GO_EXT:cell denotes cell
T3584 859-871 GO:0009986 denotes cell surface
T3585 904-908 CL_GO_EXT:cell denotes cell
T3586 909-913 CL_GO_EXT:cell denotes cell
T3587 917-921 CL_GO_EXT:cell denotes cell
T3588 922-928 GO:0031012 denotes matrix
T3589 977-983 PR_EXT:000003718 denotes ADAM22
T3590 1008-1016 CL:0000540 denotes neuronal
T3591 1008-1026 GO:0001764 denotes neuronal migration
T3592 1146-1152 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T3593 1153-1158 NCBITaxon:10088 denotes mouse
T3594 1159-1164 UBERON:0000955 denotes brain
T3595 1197-1203 PR_EXT:000003718 denotes ADAM22
T3596 1207-1215 CL:0000540 denotes neuronal
T3597 1207-1225 GO:0001764 denotes neuronal migration
T3598 1278-1283 GO:0016265 denotes death
T3599 1304-1308 UBERON:0000104 denotes life
T3600 1345-1369 UBERON:0002410 denotes autonomic nervous system
T3601 1383-1389 UBERON:0001021 denotes nerves
T3602 1396-1403 GO:0002087 denotes control
T3603 1455-1473 UBERON:0001004 denotes respiration system
T3604 1496-1506 GO_PATO_EXT:biological_maturation denotes maturation
T3605 1536-1541 GO:0007567 denotes birth
T3606 1560-1566 UBERON:0000345 denotes myelin
T3607 1582-1585 NCBITaxon:10114 denotes rat
T3608 1603-1617 SO_EXT:point_mutation_entity_or_process denotes point mutation
T3609 1625-1636 CHEBI_GO_EXT:lipoprotein_particle denotes proteolipid
T3610 1625-1644 PR_EXT:000012879 denotes proteolipid protein
T3611 1637-1644 CHEBI_PR_EXT:protein denotes protein
T3612 1646-1649 PR_EXT:000012879 denotes PLP
T3613 1651-1655 SO_EXT:0000704 denotes gene
T3614 1685-1696 GO_EXT:myelin_assembly_or_myelination denotes myelination
T3615 1701-1705 GO:0016265 denotes dies
T3616 1727-1732 GO:0007567 denotes natal
T3617 1747-1750 NCBITaxon:10114 denotes rat
T3618 1758-1763 GO:0016265 denotes death
T3619 1800-1810 UBERON:0002298 denotes brain stem
T3620 1834-1866 GO:0002087 denotes autonomic control of respiration
T3621 1935-1940 GO:0016265 denotes death
T3622 1944-1950 PR_EXT:000003718 denotes ADAM22
T3623 1961-1965 NCBITaxon:10088 denotes mice

craft-ca-core-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T3453 50-56 PR:000003718 denotes ADAM22
T3454 71-75 NCBITaxon:10088 denotes mice
T3455 92-98 PR:000003718 denotes Adam22
T3456 99-103 SO:0000704 denotes gene
T3457 105-111 PR:000003718 denotes ADAM22
T3458 122-126 NCBITaxon:10088 denotes mice
T3459 165-170 GO:0016265 denotes death
T3460 302-307 GO:0016265 denotes death
T3461 506-510 NCBITaxon:10088 denotes mice
T3462 550-554 GO:0016265 denotes died
T3463 589-597 UBERON:0001851 denotes cortical
T3464 632-637 UBERON:0000955 denotes brain
T3465 632-649 GO:0007420 denotes brain development
T3466 693-697 NCBITaxon:10088 denotes mice
T3467 710-716 CL:0000540 denotes neuron
T3468 726-747 PR:000005259 denotes activator of cyclin 5
T3469 749-752 PR:000005259 denotes p35
T3470 784-792 CL:0000540 denotes neuronal
T3471 784-802 GO:0001764 denotes neuronal migration
T3472 824-830 PR:000003718 denotes ADAM22
T3473 842-851 GO:0010467 denotes expressed
T3474 859-871 GO:0009986 denotes cell surface
T3475 922-928 GO:0031012 denotes matrix
T3476 977-983 PR:000003718 denotes ADAM22
T3477 1008-1016 CL:0000540 denotes neuronal
T3478 1008-1026 GO:0001764 denotes neuronal migration
T3479 1153-1158 NCBITaxon:10088 denotes mouse
T3480 1159-1164 UBERON:0000955 denotes brain
T3481 1197-1203 PR:000003718 denotes ADAM22
T3482 1207-1215 CL:0000540 denotes neuronal
T3483 1207-1225 GO:0001764 denotes neuronal migration
T3484 1278-1283 GO:0016265 denotes death
T3485 1304-1308 UBERON:0000104 denotes life
T3486 1345-1369 UBERON:0002410 denotes autonomic nervous system
T3487 1383-1389 UBERON:0001021 denotes nerves
T3488 1396-1403 GO:0002087 denotes control
T3489 1455-1473 UBERON:0001004 denotes respiration system
T3490 1536-1541 GO:0007567 denotes birth
T3491 1560-1566 UBERON:0000345 denotes myelin
T3492 1582-1585 NCBITaxon:10114 denotes rat
T3493 1625-1644 PR:000012879 denotes proteolipid protein
T3494 1646-1649 PR:000012879 denotes PLP
T3495 1651-1655 SO:0000704 denotes gene
T3496 1701-1705 GO:0016265 denotes dies
T3497 1727-1732 GO:0007567 denotes natal
T3498 1747-1750 NCBITaxon:10114 denotes rat
T3499 1758-1763 GO:0016265 denotes death
T3500 1800-1810 UBERON:0002298 denotes brain stem
T3501 1834-1866 GO:0002087 denotes autonomic control of respiration
T3502 1935-1940 GO:0016265 denotes death
T3503 1944-1950 PR:000003718 denotes ADAM22
T3504 1961-1965 NCBITaxon:10088 denotes mice