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PMC:1140370 / 3664-4607 JSONTXT

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Id Subject Object Predicate Lexical cue
T1206 0-2 IN denotes In
T1207 161-170 VBN denotes conducted
T1208 3-7 DT denotes this
T1209 8-14 NN denotes report
T1210 14-16 , denotes ,
T1211 16-18 IN denotes in
T1212 19-24 NN denotes order
T1213 25-27 TO denotes to
T1214 28-35 VB denotes clarify
T1215 36-39 DT denotes the
T1216 40-44 NN denotes mode
T1217 45-47 IN denotes of
T1218 48-54 NN denotes action
T1219 55-57 IN denotes of
T1220 58-61 DT denotes the
T1221 66-74 NN denotes helicase
T1222 62-65 NN denotes Mcm
T1223 75-78 CC denotes and
T1224 79-85 VB denotes obtain
T1225 86-93 NN denotes insight
T1226 94-98 IN denotes into
T1227 99-102 WRB denotes how
T1228 110-118 VB denotes function
T1229 103-105 PRP denotes it
T1230 106-109 MD denotes may
T1231 119-121 IN denotes at
T1232 122-125 DT denotes the
T1233 138-143 NNS denotes forks
T1234 126-137 NN denotes replication
T1235 144-146 FW denotes in
T1236 147-151 FW denotes vivo
T1237 151-153 , denotes ,
T1238 153-155 PRP denotes we
T1239 156-160 VBP denotes have
T1240 171-179 JJ denotes detailed
T1241 180-188 NNS denotes analyses
T1242 189-191 IN denotes of
T1243 192-200 NN denotes helicase
T1244 201-207 NN denotes action
T1245 208-211 CC denotes and
T1246 212-215 NN denotes DNA
T1247 216-223 NN denotes binding
T1248 224-226 IN denotes of
T1249 227-232 NN denotes mouse
T1250 242-250 NN denotes helicase
T1251 233-237 NN denotes Mcm4
T1252 237-238 HYPH denotes /
T1253 238-239 CD denotes 6
T1254 239-240 HYPH denotes /
T1255 240-241 CD denotes 7
T1256 251-256 VBG denotes using
T1257 257-264 JJ denotes various
T1258 293-297 NNS denotes DNAs
T1259 265-271 VBN denotes forked
T1260 272-275 CC denotes and
T1261 276-282 NN denotes bubble
T1262 283-292 NN denotes substrate
T1263 297-298 . denotes .
T1264 298-537 sentence denotes We specifically addressed sequence requirement for the Mcm helicase activation, mode of interaction with DNA substrates and whether the thymine sequences are required for continuous activation of Mcm helicase during the unwinding process.
T1265 299-301 PRP denotes We
T1266 315-324 VBD denotes addressed
T1267 302-314 RB denotes specifically
T1268 325-333 NN denotes sequence
T1269 334-345 NN denotes requirement
T1270 346-349 IN denotes for
T1271 350-353 DT denotes the
T1272 367-377 NN denotes activation
T1273 354-357 NN denotes Mcm
T1274 358-366 NN denotes helicase
T1275 377-379 , denotes ,
T1276 379-383 NN denotes mode
T1277 384-386 IN denotes of
T1278 387-398 NN denotes interaction
T1279 399-403 IN denotes with
T1280 404-407 NN denotes DNA
T1281 408-418 NNS denotes substrates
T1282 419-422 CC denotes and
T1283 423-430 IN denotes whether
T1284 457-465 VBN denotes required
T1285 431-434 DT denotes the
T1286 443-452 NNS denotes sequences
T1287 435-442 NN denotes thymine
T1288 453-456 VBP denotes are
T1289 466-469 IN denotes for
T1290 470-480 JJ denotes continuous
T1291 481-491 NN denotes activation
T1292 492-494 IN denotes of
T1293 495-498 NN denotes Mcm
T1294 499-507 NN denotes helicase
T1295 508-514 IN denotes during
T1296 515-518 DT denotes the
T1297 529-536 NN denotes process
T1298 519-528 JJ denotes unwinding
T1299 536-537 . denotes .
T1300 537-738 sentence denotes The results indicate that mammalian Mcm4/6/7 primarily binds to single-stranded DNA region, and that the extent of helicase activation is related to the thymine content of the single-stranded segment.
T1301 538-541 DT denotes The
T1302 542-549 NNS denotes results
T1303 550-558 VBP denotes indicate
T1304 559-563 IN denotes that
T1305 593-598 VBZ denotes binds
T1306 564-573 JJ denotes mammalian
T1307 574-578 NN denotes Mcm4
T1308 578-579 HYPH denotes /
T1309 579-580 CD denotes 6
T1310 580-581 HYPH denotes /
T1311 581-582 CD denotes 7
T1312 583-592 RB denotes primarily
T1313 599-601 IN denotes to
T1314 602-608 JJ denotes single
T1315 609-617 VBN denotes stranded
T1316 608-609 HYPH denotes -
T1317 622-628 NN denotes region
T1318 618-621 NN denotes DNA
T1319 628-630 , denotes ,
T1320 630-633 CC denotes and
T1321 634-638 IN denotes that
T1322 676-683 VBN denotes related
T1323 639-642 DT denotes the
T1324 643-649 NN denotes extent
T1325 650-652 IN denotes of
T1326 653-661 NN denotes helicase
T1327 662-672 NN denotes activation
T1328 673-675 VBZ denotes is
T1329 684-686 IN denotes to
T1330 687-690 DT denotes the
T1331 699-706 NN denotes content
T1332 691-698 NN denotes thymine
T1333 707-709 IN denotes of
T1334 710-713 DT denotes the
T1335 730-737 NN denotes segment
T1336 714-720 JJ denotes single
T1337 721-729 VBN denotes stranded
T1338 720-721 HYPH denotes -
T1339 737-738 . denotes .
T1340 738-943 sentence denotes Unexpectedly, Mcm4/6/7 helicase is not capable of efficiently unwinding the GC-rich duplex segment, suggesting that some other mechanism may be required for completion of replication of the entire genome.
T1341 739-751 RB denotes Unexpectedly
T1342 771-773 VBZ denotes is
T1343 751-753 , denotes ,
T1344 753-757 NN denotes Mcm4
T1345 762-770 NN denotes helicase
T1346 757-758 HYPH denotes /
T1347 758-759 CD denotes 6
T1348 759-760 HYPH denotes /
T1349 760-761 CD denotes 7
T1350 774-777 RB denotes not
T1351 778-785 JJ denotes capable
T1352 786-788 IN denotes of
T1353 789-800 RB denotes efficiently
T1354 801-810 VBG denotes unwinding
T1355 811-814 DT denotes the
T1356 830-837 NN denotes segment
T1357 815-817 NN denotes GC
T1358 818-822 JJ denotes rich
T1359 817-818 HYPH denotes -
T1360 823-829 NN denotes duplex
T1361 837-839 , denotes ,
T1362 839-849 VBG denotes suggesting
T1363 850-854 IN denotes that
T1364 883-891 VBN denotes required
T1365 855-859 DT denotes some
T1366 866-875 NN denotes mechanism
T1367 860-865 JJ denotes other
T1368 876-879 MD denotes may
T1369 880-882 VB denotes be
T1370 892-895 IN denotes for
T1371 896-906 NN denotes completion
T1372 907-909 IN denotes of
T1373 910-921 NN denotes replication
T1374 922-924 IN denotes of
T1375 925-928 DT denotes the
T1376 936-942 NN denotes genome
T1377 929-935 JJ denotes entire
T1378 942-943 . denotes .
R705 T1206 T1207 prep In,conducted
R706 T1208 T1209 det this,report
R707 T1209 T1206 pobj report,In
R708 T1210 T1207 punct ", ",conducted
R709 T1211 T1207 prep in,conducted
R710 T1212 T1211 pobj order,in
R711 T1213 T1214 aux to,clarify
R712 T1214 T1212 acl clarify,order
R713 T1215 T1216 det the,mode
R714 T1216 T1214 dobj mode,clarify
R715 T1217 T1216 prep of,mode
R716 T1218 T1217 pobj action,of
R717 T1219 T1216 prep of,mode
R718 T1220 T1221 det the,helicase
R719 T1221 T1219 pobj helicase,of
R720 T1222 T1221 compound Mcm,helicase
R721 T1223 T1214 cc and,clarify
R722 T1224 T1214 conj obtain,clarify
R723 T1225 T1224 dobj insight,obtain
R724 T1226 T1225 prep into,insight
R725 T1227 T1228 advmod how,function
R726 T1228 T1226 pcomp function,into
R727 T1229 T1228 nsubj it,function
R728 T1230 T1228 aux may,function
R729 T1231 T1228 prep at,function
R730 T1232 T1233 det the,forks
R731 T1233 T1231 pobj forks,at
R732 T1234 T1233 compound replication,forks
R733 T1235 T1236 advmod in,vivo
R734 T1236 T1228 advmod vivo,function
R735 T1237 T1207 punct ", ",conducted
R736 T1238 T1207 nsubj we,conducted
R737 T1239 T1207 aux have,conducted
R738 T1240 T1241 amod detailed,analyses
R739 T1241 T1207 dobj analyses,conducted
R740 T1242 T1241 prep of,analyses
R741 T1243 T1244 compound helicase,action
R742 T1244 T1242 pobj action,of
R743 T1245 T1244 cc and,action
R744 T1246 T1247 compound DNA,binding
R745 T1247 T1244 conj binding,action
R746 T1248 T1244 prep of,action
R747 T1249 T1250 nmod mouse,helicase
R748 T1250 T1248 pobj helicase,of
R749 T1251 T1250 nmod Mcm4,helicase
R750 T1252 T1251 punct /,Mcm4
R751 T1253 T1251 nummod 6,Mcm4
R752 T1254 T1251 punct /,Mcm4
R753 T1255 T1251 nummod 7,Mcm4
R754 T1256 T1207 advcl using,conducted
R755 T1257 T1258 amod various,DNAs
R756 T1258 T1256 dobj DNAs,using
R757 T1259 T1258 amod forked,DNAs
R758 T1260 T1259 cc and,forked
R759 T1261 T1262 compound bubble,substrate
R760 T1262 T1259 conj substrate,forked
R761 T1263 T1207 punct .,conducted
R762 T1265 T1266 nsubj We,addressed
R763 T1267 T1266 advmod specifically,addressed
R764 T1268 T1269 compound sequence,requirement
R765 T1269 T1266 dobj requirement,addressed
R766 T1270 T1269 prep for,requirement
R767 T1271 T1272 det the,activation
R768 T1272 T1270 pobj activation,for
R769 T1273 T1274 compound Mcm,helicase
R770 T1274 T1272 compound helicase,activation
R771 T1275 T1272 punct ", ",activation
R772 T1276 T1272 conj mode,activation
R773 T1277 T1276 prep of,mode
R774 T1278 T1277 pobj interaction,of
R775 T1279 T1278 prep with,interaction
R776 T1280 T1281 compound DNA,substrates
R777 T1281 T1279 pobj substrates,with
R778 T1282 T1276 cc and,mode
R779 T1283 T1284 mark whether,required
R780 T1284 T1276 conj required,mode
R781 T1285 T1286 det the,sequences
R782 T1286 T1284 nsubjpass sequences,required
R783 T1287 T1286 compound thymine,sequences
R784 T1288 T1284 auxpass are,required
R785 T1289 T1284 prep for,required
R786 T1290 T1291 amod continuous,activation
R787 T1291 T1289 pobj activation,for
R788 T1292 T1291 prep of,activation
R789 T1293 T1294 compound Mcm,helicase
R790 T1294 T1292 pobj helicase,of
R791 T1295 T1284 prep during,required
R792 T1296 T1297 det the,process
R793 T1297 T1295 pobj process,during
R794 T1298 T1297 amod unwinding,process
R795 T1299 T1266 punct .,addressed
R796 T1301 T1302 det The,results
R797 T1302 T1303 nsubj results,indicate
R798 T1304 T1305 mark that,binds
R799 T1305 T1303 advcl binds,indicate
R800 T1306 T1307 amod mammalian,Mcm4
R801 T1307 T1305 nsubj Mcm4,binds
R802 T1308 T1307 punct /,Mcm4
R803 T1309 T1307 nummod 6,Mcm4
R804 T1310 T1307 punct /,Mcm4
R805 T1311 T1307 nummod 7,Mcm4
R806 T1312 T1305 advmod primarily,binds
R807 T1313 T1305 prep to,binds
R808 T1314 T1315 amod single,stranded
R809 T1315 T1317 amod stranded,region
R810 T1316 T1315 punct -,stranded
R811 T1317 T1313 pobj region,to
R812 T1318 T1317 compound DNA,region
R813 T1319 T1305 punct ", ",binds
R814 T1320 T1305 cc and,binds
R815 T1321 T1322 mark that,related
R817 T1323 T1324 det the,extent
R818 T1324 T1322 nsubjpass extent,related
R819 T1325 T1324 prep of,extent
R820 T1326 T1327 compound helicase,activation
R821 T1327 T1325 pobj activation,of
R822 T1328 T1322 auxpass is,related
R823 T1329 T1322 prep to,related
R824 T1330 T1331 det the,content
R825 T1331 T1329 pobj content,to
R826 T1332 T1331 compound thymine,content
R827 T1333 T1331 prep of,content
R828 T1334 T1335 det the,segment
R829 T1335 T1333 pobj segment,of
R830 T1336 T1337 amod single,stranded
R831 T1337 T1335 amod stranded,segment
R832 T1338 T1337 punct -,stranded
R833 T1339 T1303 punct .,indicate
R834 T1341 T1342 advmod Unexpectedly,is
R835 T1343 T1342 punct ", ",is
R836 T1344 T1345 nmod Mcm4,helicase
R837 T1345 T1342 nsubj helicase,is
R838 T1346 T1344 punct /,Mcm4
R839 T1347 T1344 nummod 6,Mcm4
R840 T1348 T1344 punct /,Mcm4
R841 T1349 T1344 nummod 7,Mcm4
R842 T1350 T1342 neg not,is
R843 T1351 T1342 acomp capable,is
R844 T1352 T1351 prep of,capable
R845 T1353 T1354 advmod efficiently,unwinding
R846 T1354 T1352 pcomp unwinding,of
R847 T1355 T1356 det the,segment
R848 T1356 T1354 dobj segment,unwinding
R849 T1357 T1358 npadvmod GC,rich
R850 T1358 T1356 amod rich,segment
R851 T1359 T1358 punct -,rich
R852 T1360 T1356 compound duplex,segment
R853 T1361 T1342 punct ", ",is
R854 T1362 T1342 advcl suggesting,is
R855 T1363 T1364 mark that,required
R856 T1364 T1362 ccomp required,suggesting
R857 T1365 T1366 det some,mechanism
R858 T1366 T1364 nsubjpass mechanism,required
R859 T1367 T1366 amod other,mechanism
R860 T1368 T1364 aux may,required
R861 T1369 T1364 auxpass be,required
R862 T1370 T1364 prep for,required
R863 T1371 T1370 pobj completion,for
R864 T1372 T1371 prep of,completion
R865 T1373 T1372 pobj replication,of
R866 T1374 T1373 prep of,replication
R867 T1375 T1376 det the,genome
R868 T1376 T1374 pobj genome,of
R869 T1377 T1376 amod entire,genome
R870 T1378 T1342 punct .,is
R816 T1322 T1305 conj related,binds

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T722 62-65 GO:0042555 denotes Mcm
T723 66-74 GO_EXT:0004386 denotes helicase
T724 126-137 GO:0006260 denotes replication
T725 126-143 GO:0005657 denotes replication forks
T726 192-200 GO_EXT:0004386 denotes helicase
T727 212-215 CHEBI_SO_EXT:DNA denotes DNA
T728 216-223 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T729 227-232 NCBITaxon:10088 denotes mouse
T730 233-237 PR_EXT:000010246 denotes Mcm4
T731 233-241 GO:0097373 denotes Mcm4/6/7
T732 242-250 GO_EXT:0004386 denotes helicase
T733 265-271 GO:0005657 denotes forked
T734 293-297 CHEBI_SO_EXT:DNA denotes DNAs
T735 325-333 SO_EXT:biological_sequence denotes sequence
T736 354-357 GO:0042555 denotes Mcm
T737 358-366 GO_EXT:0004386 denotes helicase
T738 404-407 CHEBI_SO_EXT:DNA denotes DNA
T739 435-442 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T740 443-452 SO_EXT:biological_sequence denotes sequences
T741 495-498 GO:0042555 denotes Mcm
T742 499-507 GO_EXT:0004386 denotes helicase
T743 564-573 NCBITaxon:40674 denotes mammalian
T744 574-578 PR_EXT:000010246 denotes Mcm4
T745 574-582 GO:0097373 denotes Mcm4/6/7
T746 593-598 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T747 602-621 CHEBI_SO_EXT:single_stranded_DNA denotes single-stranded DNA
T748 653-661 GO_EXT:0004386 denotes helicase
T749 691-698 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T750 714-729 SO:0000984 denotes single-stranded
T751 753-757 PR_EXT:000010246 denotes Mcm4
T752 753-761 GO:0097373 denotes Mcm4/6/7
T753 762-770 GO_EXT:0004386 denotes helicase
T754 823-829 SO:0000985 denotes duplex
T755 910-921 GO:0006260 denotes replication
T756 936-942 SO_EXT:0001026 denotes genome

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T604 62-65 GO:0042555 denotes Mcm
T605 126-137 GO:0006260 denotes replication
T606 126-143 GO:0005657 denotes replication forks
T607 227-232 NCBITaxon:10088 denotes mouse
T608 233-237 PR:000010246 denotes Mcm4
T609 233-241 GO:0097373 denotes Mcm4/6/7
T610 265-271 GO:0005657 denotes forked
T611 354-357 GO:0042555 denotes Mcm
T612 495-498 GO:0042555 denotes Mcm
T613 564-573 NCBITaxon:40674 denotes mammalian
T614 574-578 PR:000010246 denotes Mcm4
T615 574-582 GO:0097373 denotes Mcm4/6/7
T616 602-617 SO:0000984 denotes single-stranded
T617 714-729 SO:0000984 denotes single-stranded
T618 753-757 PR:000010246 denotes Mcm4
T619 753-761 GO:0097373 denotes Mcm4/6/7
T620 823-829 SO:0000985 denotes duplex
T621 910-921 GO:0006260 denotes replication
T622 936-942 SO:0001026 denotes genome