> top > docs > PMC:1140370 > spans > 35969-37852 > annotations

PMC:1140370 / 35969-37852 JSONTXT

Annnotations TAB JSON ListView MergeView

craft-sa-dev

Id Subject Object Predicate Lexical cue
T11247 0-3 DT denotes The
T11248 4-11 NNS denotes results
T11249 41-47 VBP denotes reveal
T11250 12-21 VBN denotes described
T11251 22-24 IN denotes in
T11252 25-29 DT denotes this
T11253 30-40 NN denotes manuscript
T11254 48-59 RB denotes potentially
T11255 60-69 JJ denotes important
T11256 70-78 NNS denotes features
T11257 79-81 IN denotes of
T11258 82-91 JJ denotes mammalian
T11259 101-109 NN denotes helicase
T11260 92-96 NN denotes Mcm4
T11261 96-97 HYPH denotes /
T11262 97-98 CD denotes 6
T11263 98-99 HYPH denotes /
T11264 99-100 CD denotes 7
T11265 109-111 , denotes ,
T11266 111-116 WDT denotes which
T11267 117-119 VBZ denotes is
T11268 120-126 JJ denotes likely
T11269 127-129 TO denotes to
T11270 130-132 VB denotes be
T11271 133-134 DT denotes a
T11272 139-148 NN denotes component
T11273 135-138 JJ denotes key
T11274 149-151 IN denotes of
T11275 152-155 DT denotes the
T11276 179-187 NN denotes helicase
T11277 156-166 JJ denotes eukaryotic
T11278 167-178 JJ denotes replicative
T11279 187-188 . denotes .
T11280 188-452 sentence denotes Prior to initiation of DNA replication, Mcm helicase may adopt a double hexameric complex at the partially melted origin region, and may catalyze concurrent unwinding of duplex DNA into both directions, while stably associated with the origins of DNA replication.
T11281 189-194 JJ denotes Prior
T11282 195-197 IN denotes to
T11283 246-251 VB denotes adopt
T11284 198-208 NN denotes initiation
T11285 209-211 IN denotes of
T11286 212-215 NN denotes DNA
T11287 216-227 NN denotes replication
T11288 227-229 , denotes ,
T11289 229-232 NN denotes Mcm
T11290 233-241 NN denotes helicase
T11291 242-245 MD denotes may
T11292 252-253 DT denotes a
T11293 271-278 NN denotes complex
T11294 254-260 JJ denotes double
T11295 261-270 JJ denotes hexameric
T11296 279-281 IN denotes at
T11297 282-285 DT denotes the
T11298 310-316 NN denotes region
T11299 286-295 RB denotes partially
T11300 296-302 VBN denotes melted
T11301 303-309 NN denotes origin
T11302 316-318 , denotes ,
T11303 318-321 CC denotes and
T11304 322-325 MD denotes may
T11305 326-334 VB denotes catalyze
T11306 335-345 JJ denotes concurrent
T11307 346-355 NN denotes unwinding
T11308 356-358 IN denotes of
T11309 359-365 NN denotes duplex
T11310 366-369 NN denotes DNA
T11311 370-374 IN denotes into
T11312 375-379 DT denotes both
T11313 380-390 NNS denotes directions
T11314 390-392 , denotes ,
T11315 392-397 IN denotes while
T11316 405-415 VBN denotes associated
T11317 398-404 RB denotes stably
T11318 416-420 IN denotes with
T11319 421-424 DT denotes the
T11320 425-432 NNS denotes origins
T11321 433-435 IN denotes of
T11322 436-439 NN denotes DNA
T11323 440-451 NN denotes replication
T11324 451-452 . denotes .
T11325 452-542 sentence denotes This is similar to the T-antigen model originally proposed by Smelkova and Borowiec (21).
T11326 453-457 DT denotes This
T11327 458-460 VBZ denotes is
T11328 461-468 JJ denotes similar
T11329 469-471 IN denotes to
T11330 472-475 DT denotes the
T11331 486-491 NN denotes model
T11332 476-477 NN denotes T
T11333 478-485 NN denotes antigen
T11334 477-478 HYPH denotes -
T11335 492-502 RB denotes originally
T11336 503-511 VBN denotes proposed
T11337 512-514 IN denotes by
T11338 515-523 NNP denotes Smelkova
T11339 524-527 CC denotes and
T11340 528-536 NNP denotes Borowiec
T11341 537-538 -LRB- denotes (
T11342 538-540 CD denotes 21
T11343 540-541 -RRB- denotes )
T11344 541-542 . denotes .
T11345 542-731 sentence denotes We propose that, only when both hexamers are activated by the interacting thymine-rich sequences present within the melted region, the Mcm helicase is mobilized and initiation takes place.
T11346 543-545 PRP denotes We
T11347 546-553 VBP denotes propose
T11348 554-558 IN denotes that
T11349 694-703 VBN denotes mobilized
T11350 558-560 , denotes ,
T11351 560-564 RB denotes only
T11352 588-597 VBN denotes activated
T11353 565-569 WRB denotes when
T11354 570-574 DT denotes both
T11355 575-583 NNS denotes hexamers
T11356 584-587 VBP denotes are
T11357 598-600 IN denotes by
T11358 601-604 DT denotes the
T11359 630-639 NNS denotes sequences
T11360 605-616 VBG denotes interacting
T11361 617-624 NN denotes thymine
T11362 625-629 JJ denotes rich
T11363 624-625 HYPH denotes -
T11364 640-647 JJ denotes present
T11365 648-654 IN denotes within
T11366 655-658 DT denotes the
T11367 666-672 NN denotes region
T11368 659-665 VBN denotes melted
T11369 672-674 , denotes ,
T11370 674-677 DT denotes the
T11371 682-690 NN denotes helicase
T11372 678-681 NN denotes Mcm
T11373 691-693 VBZ denotes is
T11374 704-707 CC denotes and
T11375 708-718 NN denotes initiation
T11376 719-724 VBZ denotes takes
T11377 725-730 NN denotes place
T11378 730-731 . denotes .
T11379 731-860 sentence denotes A crucial question is how these double hexameric helicase complexes are generated and turn into active helicases at the origins.
T11380 732-733 DT denotes A
T11381 742-750 NN denotes question
T11382 734-741 JJ denotes crucial
T11383 751-753 VBZ denotes is
T11384 754-757 WRB denotes how
T11385 804-813 VBN denotes generated
T11386 758-763 DT denotes these
T11387 790-799 NNS denotes complexes
T11388 764-770 RB denotes double
T11389 771-780 JJ denotes hexameric
T11390 781-789 NN denotes helicase
T11391 800-803 VBP denotes are
T11392 814-817 CC denotes and
T11393 818-822 VB denotes turn
T11394 823-827 IN denotes into
T11395 828-834 JJ denotes active
T11396 835-844 NNS denotes helicases
T11397 845-847 IN denotes at
T11398 848-851 DT denotes the
T11399 852-859 NNS denotes origins
T11400 859-860 . denotes .
T11401 860-1114 sentence denotes This process would involve melting of duplex DNA, which may be facilitated by binding of preRC components in the context of proper chromatin structures, or by other unwinding factors including a topoisomerase or a newly identified Mcm8 helicase (34–36).
T11402 861-865 DT denotes This
T11403 866-873 NN denotes process
T11404 880-887 VB denotes involve
T11405 874-879 MD denotes would
T11406 888-895 NN denotes melting
T11407 896-898 IN denotes of
T11408 899-905 NN denotes duplex
T11409 906-909 NN denotes DNA
T11410 909-911 , denotes ,
T11411 911-916 WDT denotes which
T11412 924-935 VBN denotes facilitated
T11413 917-920 MD denotes may
T11414 921-923 VB denotes be
T11415 936-938 IN denotes by
T11416 939-946 NN denotes binding
T11417 947-949 IN denotes of
T11418 950-955 NN denotes preRC
T11419 956-966 NNS denotes components
T11420 967-969 IN denotes in
T11421 970-973 DT denotes the
T11422 974-981 NN denotes context
T11423 982-984 IN denotes of
T11424 985-991 JJ denotes proper
T11425 1002-1012 NNS denotes structures
T11426 992-1001 NN denotes chromatin
T11427 1012-1014 , denotes ,
T11428 1014-1016 CC denotes or
T11429 1017-1019 IN denotes by
T11430 1020-1025 JJ denotes other
T11431 1036-1043 NNS denotes factors
T11432 1026-1035 JJ denotes unwinding
T11433 1044-1053 VBG denotes including
T11434 1054-1055 DT denotes a
T11435 1056-1069 NN denotes topoisomerase
T11436 1070-1072 CC denotes or
T11437 1073-1074 DT denotes a
T11438 1097-1105 NN denotes helicase
T11439 1075-1080 RB denotes newly
T11440 1081-1091 VBN denotes identified
T11441 1092-1096 NN denotes Mcm8
T11442 1106-1107 -LRB- denotes (
T11443 1107-1109 CD denotes 34
T11444 1109-1110 SYM denotes –
T11445 1110-1112 CD denotes 36
T11446 1112-1113 -RRB- denotes )
T11447 1113-1114 . denotes .
T11448 1114-1262 sentence denotes It may also require association of fork-assisting proteins such as Cdc45 (37,38) as well as phosphorylation events by Cdk and Cdc7 kinases (39,40).
T11449 1115-1117 PRP denotes It
T11450 1127-1134 VB denotes require
T11451 1118-1121 MD denotes may
T11452 1122-1126 RB denotes also
T11453 1135-1146 NN denotes association
T11454 1147-1149 IN denotes of
T11455 1150-1154 NN denotes fork
T11456 1155-1164 VBG denotes assisting
T11457 1154-1155 HYPH denotes -
T11458 1165-1173 NN denotes proteins
T11459 1174-1178 JJ denotes such
T11460 1179-1181 IN denotes as
T11461 1182-1187 NN denotes Cdc45
T11462 1188-1189 -LRB- denotes (
T11463 1192-1194 CD denotes 38
T11464 1189-1191 CD denotes 37
T11465 1191-1192 , denotes ,
T11466 1194-1195 -RRB- denotes )
T11467 1196-1198 RB denotes as
T11468 1204-1206 IN denotes as
T11469 1199-1203 RB denotes well
T11470 1207-1222 NN denotes phosphorylation
T11471 1223-1229 NNS denotes events
T11472 1230-1232 IN denotes by
T11473 1233-1236 NN denotes Cdk
T11474 1246-1253 NNS denotes kinases
T11475 1237-1240 CC denotes and
T11476 1241-1245 NN denotes Cdc7
T11477 1254-1255 -LRB- denotes (
T11478 1258-1260 CD denotes 40
T11479 1255-1257 CD denotes 39
T11480 1257-1258 , denotes ,
T11481 1260-1261 -RRB- denotes )
T11482 1261-1262 . denotes .
T11483 1262-1359 sentence denotes One unexpected finding of this study is low helicase activity of Mcm4/6/7 on GC-rich duplex DNA.
T11484 1263-1266 CD denotes One
T11485 1278-1285 NN denotes finding
T11486 1267-1277 JJ denotes unexpected
T11487 1300-1302 VBZ denotes is
T11488 1286-1288 IN denotes of
T11489 1289-1293 DT denotes this
T11490 1294-1299 NN denotes study
T11491 1303-1306 JJ denotes low
T11492 1316-1324 NN denotes activity
T11493 1307-1315 NN denotes helicase
T11494 1325-1327 IN denotes of
T11495 1328-1332 NN denotes Mcm4
T11496 1332-1333 HYPH denotes /
T11497 1333-1334 CD denotes 6
T11498 1334-1335 HYPH denotes /
T11499 1335-1336 CD denotes 7
T11500 1337-1339 IN denotes on
T11501 1340-1342 NN denotes GC
T11502 1343-1347 JJ denotes rich
T11503 1342-1343 HYPH denotes -
T11504 1355-1358 NN denotes DNA
T11505 1348-1354 NN denotes duplex
T11506 1358-1359 . denotes .
T11507 1359-1544 sentence denotes This, in conjunction with the low processivity of Mcm4/6/7 helicase, strongly indicates that the replicative helicase at the replication forks would require more than Mcm4/6/7 complex.
T11508 1360-1364 DT denotes This
T11509 1438-1447 VBZ denotes indicates
T11510 1364-1366 , denotes ,
T11511 1366-1368 IN denotes in
T11512 1369-1380 NN denotes conjunction
T11513 1381-1385 IN denotes with
T11514 1386-1389 DT denotes the
T11515 1394-1406 NN denotes processivity
T11516 1390-1393 JJ denotes low
T11517 1407-1409 IN denotes of
T11518 1410-1414 NN denotes Mcm4
T11519 1419-1427 NN denotes helicase
T11520 1414-1415 HYPH denotes /
T11521 1415-1416 CD denotes 6
T11522 1416-1417 HYPH denotes /
T11523 1417-1418 CD denotes 7
T11524 1427-1429 , denotes ,
T11525 1429-1437 RB denotes strongly
T11526 1448-1452 IN denotes that
T11527 1509-1516 VB denotes require
T11528 1453-1456 DT denotes the
T11529 1469-1477 NN denotes helicase
T11530 1457-1468 JJ denotes replicative
T11531 1478-1480 IN denotes at
T11532 1481-1484 DT denotes the
T11533 1497-1502 NNS denotes forks
T11534 1485-1496 NN denotes replication
T11535 1503-1508 MD denotes would
T11536 1517-1521 JJR denotes more
T11537 1522-1526 IN denotes than
T11538 1527-1531 NN denotes Mcm4
T11539 1536-1543 NN denotes complex
T11540 1531-1532 HYPH denotes /
T11541 1532-1533 CD denotes 6
T11542 1533-1534 HYPH denotes /
T11543 1534-1535 CD denotes 7
T11544 1543-1544 . denotes .
T11545 1544-1883 sentence denotes During the processive unwinding of duplex DNA replication forks, Mcm4/6/7 may be further stimulated by interaction with other proteins, including remaining Mcm subunits, Cdc45 (37,38), GINS (41,42), DNA polymerase subunits (43), Mcm8 (35,36), etc. to become a truly processive and potent helicase capable of replicating the entire genome.
T11546 1545-1551 IN denotes During
T11547 1634-1644 VBN denotes stimulated
T11548 1552-1555 DT denotes the
T11549 1567-1576 NN denotes unwinding
T11550 1556-1566 JJ denotes processive
T11551 1577-1579 IN denotes of
T11552 1580-1586 NN denotes duplex
T11553 1603-1608 NNS denotes forks
T11554 1587-1590 NN denotes DNA
T11555 1591-1602 NN denotes replication
T11556 1608-1610 , denotes ,
T11557 1610-1614 NN denotes Mcm4
T11558 1614-1615 HYPH denotes /
T11559 1615-1616 CD denotes 6
T11560 1616-1617 HYPH denotes /
T11561 1617-1618 CD denotes 7
T11562 1619-1622 MD denotes may
T11563 1623-1625 VB denotes be
T11564 1626-1633 RB denotes further
T11565 1645-1647 IN denotes by
T11566 1648-1659 NN denotes interaction
T11567 1660-1664 IN denotes with
T11568 1665-1670 JJ denotes other
T11569 1671-1679 NN denotes proteins
T11570 1679-1681 , denotes ,
T11571 1681-1690 VBG denotes including
T11572 1691-1700 VBG denotes remaining
T11573 1705-1713 NNS denotes subunits
T11574 1701-1704 NN denotes Mcm
T11575 1713-1715 , denotes ,
T11576 1715-1720 NN denotes Cdc45
T11577 1721-1722 -LRB- denotes (
T11578 1725-1727 CD denotes 38
T11579 1722-1724 CD denotes 37
T11580 1724-1725 , denotes ,
T11581 1727-1728 -RRB- denotes )
T11582 1728-1730 , denotes ,
T11583 1730-1734 NN denotes GINS
T11584 1735-1736 -LRB- denotes (
T11585 1739-1741 CD denotes 42
T11586 1736-1738 CD denotes 41
T11587 1738-1739 , denotes ,
T11588 1741-1742 -RRB- denotes )
T11589 1742-1744 , denotes ,
T11590 1744-1747 NN denotes DNA
T11597 1774-1778 NN denotes Mcm8
T11598 1779-1780 -LRB- denotes (
T11599 1783-1785 CD denotes 36
T11600 1780-1782 CD denotes 35
T11601 1782-1783 , denotes ,
T11602 1785-1786 -RRB- denotes )
T11603 1786-1788 , denotes ,
T11604 1788-1792 FW denotes etc.
T11605 1793-1795 TO denotes to
T11606 1796-1802 VB denotes become
T11607 1803-1804 DT denotes a
T11608 1833-1841 NN denotes helicase
T11609 1805-1810 RB denotes truly
T11610 1811-1821 JJ denotes processive
T11611 1822-1825 CC denotes and
T11612 1826-1832 JJ denotes potent
T11613 1842-1849 JJ denotes capable
T11614 1850-1852 IN denotes of
T11615 1853-1864 VBG denotes replicating
T11616 1865-1868 DT denotes the
T11617 1876-1882 NN denotes genome
T11618 1869-1875 JJ denotes entire
T11619 1882-1883 . denotes .
T11591 1759-1767 NNS denotes subunits
T11592 1748-1758 NN denotes polymerase
T11593 1768-1769 -LRB- denotes (
T11594 1769-1771 CD denotes 43
T11595 1771-1772 -RRB- denotes )
T11596 1772-1774 , denotes ,
R7435 T11247 T11248 det The,results
R7436 T11248 T11249 nsubj results,reveal
R7437 T11250 T11248 acl described,results
R7438 T11251 T11250 prep in,described
R7439 T11252 T11253 det this,manuscript
R7440 T11253 T11251 pobj manuscript,in
R7441 T11254 T11255 advmod potentially,important
R7442 T11255 T11256 amod important,features
R7443 T11256 T11249 dobj features,reveal
R7444 T11257 T11256 prep of,features
R7445 T11258 T11259 amod mammalian,helicase
R7446 T11259 T11257 pobj helicase,of
R7447 T11260 T11259 nmod Mcm4,helicase
R7448 T11261 T11260 punct /,Mcm4
R7449 T11262 T11260 nummod 6,Mcm4
R7450 T11263 T11260 punct /,Mcm4
R7451 T11264 T11260 nummod 7,Mcm4
R7452 T11265 T11259 punct ", ",helicase
R7453 T11266 T11267 dep which,is
R7454 T11267 T11259 relcl is,helicase
R7455 T11268 T11267 acomp likely,is
R7456 T11269 T11270 aux to,be
R7457 T11270 T11268 xcomp be,likely
R7458 T11271 T11272 det a,component
R7459 T11272 T11270 attr component,be
R7460 T11273 T11272 amod key,component
R7461 T11274 T11272 prep of,component
R7462 T11275 T11276 det the,helicase
R7463 T11276 T11274 pobj helicase,of
R7464 T11277 T11276 amod eukaryotic,helicase
R7465 T11278 T11276 amod replicative,helicase
R7466 T11279 T11249 punct .,reveal
R7467 T11281 T11282 amod Prior,to
R7468 T11282 T11283 prep to,adopt
R7469 T11284 T11282 pobj initiation,to
R7470 T11285 T11284 prep of,initiation
R7471 T11286 T11287 compound DNA,replication
R7472 T11287 T11285 pobj replication,of
R7473 T11288 T11283 punct ", ",adopt
R7474 T11289 T11290 compound Mcm,helicase
R7475 T11290 T11283 nsubj helicase,adopt
R7476 T11291 T11283 aux may,adopt
R7477 T11292 T11293 det a,complex
R7478 T11293 T11283 dobj complex,adopt
R7479 T11294 T11295 amod double,hexameric
R7480 T11295 T11293 amod hexameric,complex
R7481 T11296 T11283 prep at,adopt
R7482 T11297 T11298 det the,region
R7483 T11298 T11296 pobj region,at
R7484 T11299 T11300 advmod partially,melted
R7485 T11300 T11298 amod melted,region
R7486 T11301 T11298 compound origin,region
R7487 T11302 T11283 punct ", ",adopt
R7488 T11303 T11283 cc and,adopt
R7489 T11304 T11305 aux may,catalyze
R7490 T11305 T11283 conj catalyze,adopt
R7491 T11306 T11307 amod concurrent,unwinding
R7492 T11307 T11305 dobj unwinding,catalyze
R7493 T11308 T11307 prep of,unwinding
R7494 T11309 T11310 compound duplex,DNA
R7495 T11310 T11308 pobj DNA,of
R7496 T11311 T11305 prep into,catalyze
R7497 T11312 T11313 det both,directions
R7498 T11313 T11311 pobj directions,into
R7499 T11314 T11283 punct ", ",adopt
R7500 T11315 T11316 mark while,associated
R7501 T11316 T11283 advcl associated,adopt
R7502 T11317 T11316 advmod stably,associated
R7503 T11318 T11316 prep with,associated
R7504 T11319 T11320 det the,origins
R7505 T11320 T11318 pobj origins,with
R7506 T11321 T11320 prep of,origins
R7507 T11322 T11323 compound DNA,replication
R7508 T11323 T11321 pobj replication,of
R7509 T11324 T11283 punct .,adopt
R7510 T11326 T11327 nsubj This,is
R7511 T11328 T11327 acomp similar,is
R7512 T11329 T11328 prep to,similar
R7513 T11330 T11331 det the,model
R7514 T11331 T11329 pobj model,to
R7515 T11332 T11333 compound T,antigen
R7516 T11333 T11331 compound antigen,model
R7517 T11334 T11333 punct -,antigen
R7518 T11335 T11336 advmod originally,proposed
R7519 T11336 T11331 acl proposed,model
R7520 T11337 T11336 agent by,proposed
R7521 T11338 T11337 pobj Smelkova,by
R7522 T11339 T11338 cc and,Smelkova
R7523 T11340 T11338 conj Borowiec,Smelkova
R7524 T11341 T11342 punct (,21
R7525 T11342 T11340 parataxis 21,Borowiec
R7526 T11343 T11342 punct ),21
R7527 T11344 T11327 punct .,is
R7528 T11346 T11347 nsubj We,propose
R7529 T11348 T11349 mark that,mobilized
R7530 T11349 T11347 ccomp mobilized,propose
R7531 T11350 T11349 punct ", ",mobilized
R7532 T11351 T11352 advmod only,activated
R7533 T11352 T11349 advcl activated,mobilized
R7534 T11353 T11352 advmod when,activated
R7535 T11354 T11355 det both,hexamers
R7536 T11355 T11352 nsubjpass hexamers,activated
R7537 T11356 T11352 auxpass are,activated
R7538 T11357 T11352 agent by,activated
R7539 T11358 T11359 det the,sequences
R7540 T11359 T11357 pobj sequences,by
R7541 T11360 T11359 amod interacting,sequences
R7542 T11361 T11362 npadvmod thymine,rich
R7543 T11362 T11359 amod rich,sequences
R7544 T11363 T11362 punct -,rich
R7545 T11364 T11359 relcl present,sequences
R7546 T11365 T11364 prep within,present
R7547 T11366 T11367 det the,region
R7548 T11367 T11365 pobj region,within
R7549 T11368 T11367 amod melted,region
R7550 T11369 T11349 punct ", ",mobilized
R7551 T11370 T11371 det the,helicase
R7552 T11371 T11349 nsubjpass helicase,mobilized
R7553 T11372 T11371 compound Mcm,helicase
R7554 T11373 T11349 auxpass is,mobilized
R7555 T11374 T11349 cc and,mobilized
R7556 T11375 T11376 nsubj initiation,takes
R7557 T11376 T11349 conj takes,mobilized
R7558 T11377 T11376 dobj place,takes
R7559 T11378 T11347 punct .,propose
R7560 T11380 T11381 det A,question
R7561 T11381 T11383 nsubj question,is
R7562 T11382 T11381 amod crucial,question
R7563 T11384 T11385 advmod how,generated
R7564 T11385 T11383 ccomp generated,is
R7565 T11386 T11387 det these,complexes
R7566 T11387 T11385 nsubjpass complexes,generated
R7567 T11388 T11389 advmod double,hexameric
R7568 T11389 T11387 amod hexameric,complexes
R7569 T11390 T11387 compound helicase,complexes
R7570 T11391 T11385 auxpass are,generated
R7571 T11392 T11385 cc and,generated
R7572 T11393 T11385 conj turn,generated
R7573 T11394 T11393 prep into,turn
R7574 T11395 T11396 amod active,helicases
R7575 T11396 T11394 pobj helicases,into
R7576 T11397 T11393 prep at,turn
R7577 T11398 T11399 det the,origins
R7578 T11399 T11397 pobj origins,at
R7579 T11400 T11383 punct .,is
R7580 T11402 T11403 det This,process
R7581 T11403 T11404 nsubj process,involve
R7582 T11405 T11404 aux would,involve
R7583 T11406 T11404 dobj melting,involve
R7584 T11407 T11406 prep of,melting
R7585 T11408 T11409 compound duplex,DNA
R7586 T11409 T11407 pobj DNA,of
R7587 T11410 T11406 punct ", ",melting
R7588 T11411 T11412 dep which,facilitated
R7589 T11412 T11406 relcl facilitated,melting
R7590 T11413 T11412 aux may,facilitated
R7591 T11414 T11412 auxpass be,facilitated
R7592 T11415 T11412 prep by,facilitated
R7593 T11416 T11415 pobj binding,by
R7594 T11417 T11416 prep of,binding
R7595 T11418 T11419 compound preRC,components
R7596 T11419 T11417 pobj components,of
R7597 T11420 T11416 prep in,binding
R7598 T11421 T11422 det the,context
R7599 T11422 T11420 pobj context,in
R7600 T11423 T11422 prep of,context
R7601 T11424 T11425 amod proper,structures
R7602 T11425 T11423 pobj structures,of
R7603 T11426 T11425 compound chromatin,structures
R7604 T11427 T11415 punct ", ",by
R7605 T11428 T11415 cc or,by
R7606 T11429 T11415 conj by,by
R7607 T11430 T11431 amod other,factors
R7608 T11431 T11429 pobj factors,by
R7609 T11432 T11431 amod unwinding,factors
R7610 T11433 T11431 prep including,factors
R7611 T11434 T11435 det a,topoisomerase
R7612 T11435 T11433 pobj topoisomerase,including
R7613 T11436 T11435 cc or,topoisomerase
R7614 T11437 T11438 det a,helicase
R7615 T11438 T11435 conj helicase,topoisomerase
R7616 T11439 T11440 advmod newly,identified
R7617 T11440 T11438 amod identified,helicase
R7618 T11441 T11438 compound Mcm8,helicase
R7619 T11442 T11443 punct (,34
R7620 T11443 T11404 parataxis 34,involve
R7621 T11444 T11445 punct –,36
R7622 T11445 T11443 prep 36,34
R7623 T11446 T11443 punct ),34
R7624 T11447 T11404 punct .,involve
R7625 T11449 T11450 nsubj It,require
R7626 T11451 T11450 aux may,require
R7627 T11452 T11450 advmod also,require
R7628 T11453 T11450 dobj association,require
R7629 T11454 T11453 prep of,association
R7630 T11455 T11456 npadvmod fork,assisting
R7631 T11456 T11458 amod assisting,proteins
R7632 T11457 T11456 punct -,assisting
R7633 T11458 T11454 pobj proteins,of
R7634 T11459 T11460 amod such,as
R7635 T11460 T11458 prep as,proteins
R7636 T11461 T11460 pobj Cdc45,as
R7637 T11462 T11463 punct (,38
R7638 T11463 T11461 parataxis 38,Cdc45
R7639 T11464 T11463 nummod 37,38
R7640 T11465 T11463 punct ",",38
R7641 T11466 T11463 punct ),38
R7642 T11467 T11468 advmod as,as
R7643 T11468 T11458 cc as,proteins
R7644 T11469 T11468 advmod well,as
R7645 T11470 T11471 compound phosphorylation,events
R7646 T11471 T11458 conj events,proteins
R7647 T11472 T11471 prep by,events
R7648 T11473 T11474 nmod Cdk,kinases
R7649 T11474 T11472 pobj kinases,by
R7650 T11475 T11473 cc and,Cdk
R7651 T11476 T11473 conj Cdc7,Cdk
R7652 T11477 T11478 punct (,40
R7653 T11478 T11474 parataxis 40,kinases
R7654 T11479 T11478 nummod 39,40
R7655 T11480 T11478 punct ",",40
R7656 T11481 T11478 punct ),40
R7657 T11482 T11450 punct .,require
R7658 T11484 T11485 nummod One,finding
R7659 T11485 T11487 nsubj finding,is
R7660 T11486 T11485 amod unexpected,finding
R7661 T11488 T11485 prep of,finding
R7662 T11489 T11490 det this,study
R7663 T11490 T11488 pobj study,of
R7664 T11491 T11492 amod low,activity
R7665 T11492 T11487 attr activity,is
R7666 T11493 T11492 compound helicase,activity
R7667 T11494 T11492 prep of,activity
R7668 T11495 T11494 pobj Mcm4,of
R7669 T11496 T11495 punct /,Mcm4
R7670 T11497 T11495 nummod 6,Mcm4
R7671 T11498 T11495 punct /,Mcm4
R7672 T11499 T11495 nummod 7,Mcm4
R7673 T11500 T11492 prep on,activity
R7674 T11501 T11502 npadvmod GC,rich
R7675 T11502 T11504 amod rich,DNA
R7676 T11503 T11502 punct -,rich
R7677 T11504 T11500 pobj DNA,on
R7678 T11505 T11504 compound duplex,DNA
R7679 T11506 T11487 punct .,is
R7680 T11508 T11509 nsubj This,indicates
R7681 T11510 T11508 punct ", ",This
R7682 T11511 T11508 prep in,This
R7683 T11512 T11511 pobj conjunction,in
R7684 T11513 T11512 prep with,conjunction
R7685 T11514 T11515 det the,processivity
R7686 T11515 T11513 pobj processivity,with
R7687 T11516 T11515 amod low,processivity
R7688 T11517 T11515 prep of,processivity
R7689 T11518 T11519 nmod Mcm4,helicase
R7690 T11519 T11517 pobj helicase,of
R7691 T11520 T11518 punct /,Mcm4
R7692 T11521 T11518 nummod 6,Mcm4
R7693 T11522 T11518 punct /,Mcm4
R7694 T11523 T11518 nummod 7,Mcm4
R7695 T11524 T11509 punct ", ",indicates
R7696 T11525 T11509 advmod strongly,indicates
R7697 T11526 T11527 mark that,require
R7698 T11527 T11509 ccomp require,indicates
R7699 T11528 T11529 det the,helicase
R7700 T11529 T11527 nsubj helicase,require
R7701 T11530 T11529 amod replicative,helicase
R7702 T11531 T11529 prep at,helicase
R7703 T11532 T11533 det the,forks
R7704 T11533 T11531 pobj forks,at
R7705 T11534 T11533 compound replication,forks
R7706 T11535 T11527 aux would,require
R7707 T11536 T11527 dobj more,require
R7708 T11537 T11536 prep than,more
R7709 T11538 T11539 nmod Mcm4,complex
R7710 T11539 T11537 pobj complex,than
R7711 T11540 T11538 punct /,Mcm4
R7712 T11541 T11538 nummod 6,Mcm4
R7713 T11542 T11538 punct /,Mcm4
R7714 T11543 T11538 nummod 7,Mcm4
R7715 T11544 T11509 punct .,indicates
R7716 T11546 T11547 prep During,stimulated
R7717 T11548 T11549 det the,unwinding
R7718 T11549 T11546 pobj unwinding,During
R7719 T11550 T11549 amod processive,unwinding
R7720 T11551 T11549 prep of,unwinding
R7721 T11552 T11553 compound duplex,forks
R7722 T11553 T11551 pobj forks,of
R7723 T11554 T11553 compound DNA,forks
R7724 T11555 T11553 compound replication,forks
R7725 T11556 T11547 punct ", ",stimulated
R7726 T11557 T11547 nsubjpass Mcm4,stimulated
R7727 T11558 T11557 punct /,Mcm4
R7728 T11559 T11557 nummod 6,Mcm4
R7729 T11560 T11557 punct /,Mcm4
R7730 T11561 T11557 nummod 7,Mcm4
R7731 T11562 T11547 aux may,stimulated
R7732 T11563 T11547 auxpass be,stimulated
R7733 T11564 T11547 advmod further,stimulated
R7734 T11565 T11547 agent by,stimulated
R7735 T11566 T11565 pobj interaction,by
R7736 T11567 T11566 prep with,interaction
R7737 T11568 T11569 amod other,proteins
R7738 T11569 T11567 pobj proteins,with
R7739 T11570 T11569 punct ", ",proteins
R7740 T11571 T11569 prep including,proteins
R7741 T11572 T11573 amod remaining,subunits
R7742 T11573 T11571 pobj subunits,including
R7743 T11574 T11573 compound Mcm,subunits
R7744 T11575 T11573 punct ", ",subunits
R7745 T11576 T11573 conj Cdc45,subunits
R7746 T11577 T11578 punct (,38
R7747 T11578 T11576 parataxis 38,Cdc45
R7748 T11579 T11578 nummod 37,38
R7749 T11580 T11578 punct ",",38
R7750 T11581 T11578 punct ),38
R7751 T11582 T11576 punct ", ",Cdc45
R7752 T11583 T11576 conj GINS,Cdc45
R7753 T11584 T11585 punct (,42
R7754 T11585 T11583 parataxis 42,GINS
R7755 T11586 T11585 nummod 41,42
R7756 T11587 T11585 punct ",",42
R7757 T11588 T11585 punct ),42
R7758 T11589 T11583 punct ", ",GINS
R7759 T11590 T11591 compound DNA,subunits
R7760 T11591 T11583 conj subunits,GINS
R7761 T11592 T11591 compound polymerase,subunits
R7762 T11593 T11594 punct (,43
R7763 T11594 T11591 parataxis 43,subunits
R7764 T11595 T11594 punct ),43
R7765 T11596 T11591 punct ", ",subunits
R7766 T11597 T11591 conj Mcm8,subunits
R7767 T11598 T11599 punct (,36
R7768 T11599 T11597 parataxis 36,Mcm8
R7769 T11600 T11599 nummod 35,36
R7770 T11601 T11599 punct ",",36
R7771 T11602 T11599 punct ),36
R7772 T11603 T11597 punct ", ",Mcm8
R7773 T11604 T11597 conj etc.,Mcm8
R7774 T11605 T11606 aux to,become
R7775 T11606 T11547 advcl become,stimulated
R7776 T11607 T11608 det a,helicase
R7777 T11608 T11606 attr helicase,become
R7778 T11609 T11610 advmod truly,processive
R7779 T11610 T11608 amod processive,helicase
R7780 T11611 T11610 cc and,processive
R7781 T11612 T11610 conj potent,processive
R7782 T11613 T11608 amod capable,helicase
R7783 T11614 T11613 prep of,capable
R7784 T11615 T11614 pcomp replicating,of
R7785 T11616 T11617 det the,genome
R7786 T11617 T11615 dobj genome,replicating
R7787 T11618 T11617 amod entire,genome
R7788 T11619 T11547 punct .,stimulated

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T10778 82-91 NCBITaxon:40674 denotes mammalian
T10779 92-96 PR_EXT:000010246 denotes Mcm4
T10780 92-100 GO:0097373 denotes Mcm4/6/7
T10781 101-109 GO_EXT:0004386 denotes helicase
T10782 156-166 NCBITaxon:2759 denotes eukaryotic
T10783 167-178 GO:0006260 denotes replicative
T10784 179-187 GO_EXT:0004386 denotes helicase
T10785 198-227 GO:0006270 denotes initiation of DNA replication
T10786 212-215 CHEBI_SO_EXT:DNA denotes DNA
T10787 229-232 GO:0042555 denotes Mcm
T10788 233-241 GO_EXT:0004386 denotes helicase
T10789 254-278 GO_EXT:double_hexameric_macromolecular_complex denotes double hexameric complex
T10790 296-302 GO:0032508 denotes melted
T10791 303-309 SO_EXT:0000296 denotes origin
T10792 326-334 GO_MOP_EXT:catalysis denotes catalyze
T10793 346-369 GO:0032508 denotes unwinding of duplex DNA
T10794 359-369 CHEBI_SO_EXT:double_stranded_DNA denotes duplex DNA
T10795 425-451 SO_EXT:0000296 denotes origins of DNA replication
T10796 436-439 CHEBI_SO_EXT:DNA denotes DNA
T10797 436-451 GO:0006260 denotes DNA replication
T10798 478-485 CHEBI_EXT:59132 denotes antigen
T10799 575-583 GO_EXT:hexameric_macromolecular_complex denotes hexamers
T10800 617-624 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T10801 630-639 SO_EXT:biological_sequence denotes sequences
T10802 659-665 GO:0032508 denotes melted
T10803 678-681 GO:0042555 denotes Mcm
T10804 682-690 GO_EXT:0004386 denotes helicase
T10805 694-703 GO_EXT:biological_recruitment denotes mobilized
T10806 764-780 _FRAGMENT denotes double hexameric
T10807 790-799 GO_EXT:double_hexameric_macromolecular_complex denotes complexes
T10808 781-789 GO_EXT:0004386 denotes helicase
T10809 781-799 GO:0033202 denotes helicase complexes
T10810 835-844 GO_EXT:0004386 denotes helicases
T10811 852-859 SO_EXT:0000296 denotes origins
T10812 888-909 GO:0032508 denotes melting of duplex DNA
T10813 899-909 CHEBI_SO_EXT:double_stranded_DNA denotes duplex DNA
T10814 939-946 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T10815 950-955 GO:0005656 denotes preRC
T10816 992-1001 GO:0000785 denotes chromatin
T10817 1056-1069 GO_EXT:0003916 denotes topoisomerase
T10818 1092-1096 PR_EXT:000010250 denotes Mcm8
T10819 1097-1105 GO_EXT:0004386 denotes helicase
T10820 1150-1154 GO:0005657 denotes fork
T10821 1165-1173 CHEBI_PR_EXT:protein denotes proteins
T10822 1182-1187 PR_EXT:000005215 denotes Cdc45
T10823 1207-1222 GO_PATO_EXT:phosphorylation_process denotes phosphorylation
T10824 1233-1236 _FRAGMENT denotes Cdk
T10825 1246-1253 GO_EXT:0097472 denotes kinases
T10826 1241-1245 PR_EXT:000005218 denotes Cdc7
T10827 1307-1315 GO_EXT:0004386 denotes helicase
T10828 1328-1332 PR_EXT:000010246 denotes Mcm4
T10829 1328-1336 GO:0097373 denotes Mcm4/6/7
T10830 1348-1358 CHEBI_SO_EXT:double_stranded_DNA denotes duplex DNA
T10831 1410-1414 PR_EXT:000010246 denotes Mcm4
T10854 1876-1882 SO_EXT:0001026 denotes genome
T10832 1410-1418 GO:0097373 denotes Mcm4/6/7
T10833 1419-1427 GO_EXT:0004386 denotes helicase
T10834 1457-1468 GO:0006260 denotes replicative
T10835 1469-1477 GO_EXT:0004386 denotes helicase
T10836 1485-1496 GO:0006260 denotes replication
T10837 1485-1502 GO:0005657 denotes replication forks
T10838 1527-1531 PR_EXT:000010246 denotes Mcm4
T10839 1527-1543 GO:0097373 denotes Mcm4/6/7 complex
T10840 1580-1590 CHEBI_SO_EXT:double_stranded_DNA denotes duplex DNA
T10841 1587-1602 GO:0006260 denotes DNA replication
T10842 1587-1608 GO:0005657 denotes DNA replication forks
T10843 1610-1614 PR_EXT:000010246 denotes Mcm4
T10844 1610-1618 GO:0097373 denotes Mcm4/6/7
T10845 1671-1679 CHEBI_PR_EXT:protein denotes proteins
T10846 1701-1704 GO:0042555 denotes Mcm
T10847 1715-1720 PR_EXT:000005215 denotes Cdc45
T10848 1730-1734 GO:0000811 denotes GINS
T10849 1744-1747 CHEBI_SO_EXT:DNA denotes DNA
T10850 1744-1758 GO_EXT:0034061 denotes DNA polymerase
T10851 1774-1778 PR_EXT:000010250 denotes Mcm8
T10852 1833-1841 GO_EXT:0004386 denotes helicase
T10853 1853-1864 GO:0006260 denotes replicating
R7065 T10807 T10806 _lexicallyChainedTo complexes,double hexameric
R7066 T10825 T10824 _lexicallyChainedTo kinases,Cdk

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T10672 359-365 SO:0000985 denotes duplex
T10673 425-451 SO:0000296 denotes origins of DNA replication
T10674 436-451 GO:0006260 denotes DNA replication
T10675 478-485 CHEBI:59132 denotes antigen
T10676 659-665 GO:0032508 denotes melted
T10677 678-681 GO:0042555 denotes Mcm
T10678 781-799 GO:0033202 denotes helicase complexes
T10679 852-859 SO:0000296 denotes origins
T10680 888-909 GO:0032508 denotes melting of duplex DNA
T10681 899-905 SO:0000985 denotes duplex
T10682 950-955 GO:0005656 denotes preRC
T10683 992-1001 GO:0000785 denotes chromatin
T10684 1092-1096 PR:000010250 denotes Mcm8
T10685 1150-1154 GO:0005657 denotes fork
T10686 1182-1187 PR:000005215 denotes Cdc45
T10687 1241-1245 PR:000005218 denotes Cdc7
T10688 1328-1332 PR:000010246 denotes Mcm4
T10689 1328-1336 GO:0097373 denotes Mcm4/6/7
T10690 1348-1354 SO:0000985 denotes duplex
T10691 1410-1414 PR:000010246 denotes Mcm4
T10692 1410-1418 GO:0097373 denotes Mcm4/6/7
T10693 1457-1468 GO:0006260 denotes replicative
T10694 1485-1496 GO:0006260 denotes replication
T10695 1485-1502 GO:0005657 denotes replication forks
T10696 1527-1531 PR:000010246 denotes Mcm4
T10697 1527-1543 GO:0097373 denotes Mcm4/6/7 complex
T10698 1580-1586 SO:0000985 denotes duplex
T10699 1587-1602 GO:0006260 denotes DNA replication
T10700 1587-1608 GO:0005657 denotes DNA replication forks
T10701 1610-1614 PR:000010246 denotes Mcm4
T10702 1610-1618 GO:0097373 denotes Mcm4/6/7
T10703 1701-1704 GO:0042555 denotes Mcm
T10704 1715-1720 PR:000005215 denotes Cdc45
T10705 1730-1734 GO:0000811 denotes GINS
T10706 1774-1778 PR:000010250 denotes Mcm8
T10707 1853-1864 GO:0006260 denotes replicating
T10708 1876-1882 SO:0001026 denotes genome
T10662 82-91 NCBITaxon:40674 denotes mammalian
T10663 92-96 PR:000010246 denotes Mcm4
T10664 92-100 GO:0097373 denotes Mcm4/6/7
T10665 156-166 NCBITaxon:2759 denotes eukaryotic
T10666 167-178 GO:0006260 denotes replicative
T10667 198-227 GO:0006270 denotes initiation of DNA replication
T10668 229-232 GO:0042555 denotes Mcm
T10669 296-302 GO:0032508 denotes melted
T10670 303-309 SO:0000296 denotes origin
T10671 346-369 GO:0032508 denotes unwinding of duplex DNA

2_test

Id Subject Object Predicate Lexical cue
15917436-9765408-76775546 538-540 9765408 denotes 21
15917436-14993926-76775547 1107-1109 14993926 denotes 34
15917436-15707891-76775547 1107-1109 15707891 denotes 34
15917436-15684404-76775547 1107-1109 15684404 denotes 34
15917436-9001208-76775548 1189-1191 9001208 denotes 37
15917436-12581157-76775549 1192-1194 12581157 denotes 38
15917436-10748114-76775550 1255-1257 10748114 denotes 39
15917436-10846177-76775551 1258-1260 10846177 denotes 40
15917436-9001208-76775552 1722-1724 9001208 denotes 37
15917436-12581157-76775553 1725-1727 12581157 denotes 38
15917436-12730134-76775554 1736-1738 12730134 denotes 41
15917436-12730133-76775555 1739-1741 12730133 denotes 42
15917436-11804324-76775556 1769-1771 11804324 denotes 43
15917436-15707891-76775557 1780-1782 15707891 denotes 35
15917436-15684404-76775558 1783-1785 15684404 denotes 36