PMC:1140370 / 32090-32644 JSONTXT

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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1140370","sourcedb":"PMC","sourceid":"1140370","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1140370","text":"Occurrence of AT-rich sequences, with asymmetric distribution of adenine and thymine, near the replication origins, lead us to propose that Mcm may play a role in selection of initiation sites of mammalian DNA replication, and prompted us to examine the ability of sequences from human replication origins to activate Mcm4/6/7 helicase. Both lamin-B2 and c-myc origins served as efficient activator for Mcm helicase in vitro. 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