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Id Subject Object Predicate Lexical cue
T9856 0-9 NN denotes Substrate
T9857 23-34 NN denotes requirement
T9858 10-13 CC denotes and
T9859 14-22 NN denotes sequence
T9860 35-38 IN denotes for
T9861 39-43 NN denotes Mcm4
T9862 57-67 NN denotes activation
T9863 43-44 HYPH denotes /
T9864 44-45 CD denotes 6
T9865 45-46 HYPH denotes /
T9866 46-47 CD denotes 7
T9867 48-56 NN denotes helicase
T9868 67-245 sentence denotes DNA binding assays indicate that Mcm4/6/7 binds to those substrates containing single-stranded DNA regions regardless of the presence or absence of single-stranded 3′ or 5′ end.
T9869 68-71 NN denotes DNA
T9870 72-79 NN denotes binding
T9871 80-86 NNS denotes assays
T9872 87-95 VBP denotes indicate
T9873 96-100 IN denotes that
T9874 110-115 VBZ denotes binds
T9875 101-105 NN denotes Mcm4
T9876 105-106 HYPH denotes /
T9877 106-107 CD denotes 6
T9878 107-108 HYPH denotes /
T9879 108-109 CD denotes 7
T9880 116-118 IN denotes to
T9881 119-124 DT denotes those
T9882 125-135 NNS denotes substrates
T9883 136-146 VBG denotes containing
T9884 147-153 JJ denotes single
T9885 154-162 VBN denotes stranded
T9886 153-154 HYPH denotes -
T9887 167-174 NNS denotes regions
T9888 163-166 NN denotes DNA
T9889 175-185 RB denotes regardless
T9890 186-188 IN denotes of
T9891 189-192 DT denotes the
T9892 193-201 NN denotes presence
T9893 202-204 CC denotes or
T9894 205-212 NN denotes absence
T9895 213-215 IN denotes of
T9896 216-222 JJ denotes single
T9897 223-231 VBN denotes stranded
T9898 222-223 HYPH denotes -
T9899 241-244 NN denotes end
T9900 232-233 CD denotes 3
T9901 233-234 SYM denotes ′
T9902 235-237 CC denotes or
T9903 238-239 CD denotes 5
T9904 239-240 SYM denotes ′
T9905 244-245 . denotes .
T9906 245-346 sentence denotes Unwinding of the duplex DNA depends on translocation of single-stranded DNA from 3′ to 5′ direction.
T9907 246-255 NN denotes Unwinding
T9908 274-281 VBZ denotes depends
T9909 256-258 IN denotes of
T9910 259-262 DT denotes the
T9911 270-273 NN denotes DNA
T9912 263-269 NN denotes duplex
T9913 282-284 IN denotes on
T9914 285-298 NN denotes translocation
T9915 299-301 IN denotes of
T9916 302-308 JJ denotes single
T9917 309-317 VBN denotes stranded
T9918 308-309 HYPH denotes -
T9919 318-321 NN denotes DNA
T9920 322-326 IN denotes from
T9921 327-328 CD denotes 3
T9922 328-329 SYM denotes ′
T9923 330-332 IN denotes to
T9924 333-334 CD denotes 5
T9925 334-335 SYM denotes ′
T9926 336-345 NN denotes direction
T9927 345-346 . denotes .
T9928 346-482 sentence denotes This is most clearly shown by its helicase action on A-fork[5′] and 3′-extension but not on A-fork[3′], A-fork[3′,5′] nor 5′-extension.
T9929 347-351 DT denotes This
T9930 368-373 VBN denotes shown
T9931 352-354 VBZ denotes is
T9932 355-359 RBS denotes most
T9933 360-367 RB denotes clearly
T9934 374-376 IN denotes by
T9935 377-380 PRP$ denotes its
T9936 390-396 NN denotes action
T9937 381-389 NN denotes helicase
T9938 397-399 IN denotes on
T9939 400-401 NN denotes A
T9940 402-406 NN denotes fork
T9941 401-402 HYPH denotes -
T9942 418-427 NN denotes extension
T9943 406-407 -LRB- denotes [
T9944 407-408 CD denotes 5
T9945 408-409 SYM denotes ′
T9946 409-410 -RRB- denotes ]
T9947 411-414 CC denotes and
T9948 415-416 CD denotes 3
T9949 416-417 SYM denotes ′
T9950 417-418 HYPH denotes -
T9951 428-431 CC denotes but
T9952 432-435 RB denotes not
T9953 436-438 IN denotes on
T9954 439-440 NN denotes A
T9955 441-445 NN denotes fork
T9956 440-441 HYPH denotes -
T9957 472-481 NN denotes extension
T9958 445-446 -LRB- denotes [
T9959 446-447 CD denotes 3
T9960 447-448 SYM denotes ′
T9961 448-449 -RRB- denotes ]
T9962 449-451 , denotes ,
T9963 451-452 NN denotes A
T9964 453-457 NN denotes fork
T9965 452-453 HYPH denotes -
T9966 457-458 -LRB- denotes [
T9967 458-459 CD denotes 3
T9968 459-460 SYM denotes ′
T9969 460-461 , denotes ,
T9970 461-462 CD denotes 5
T9971 462-463 SYM denotes ′
T9972 463-464 -RRB- denotes ]
T9973 465-468 CC denotes nor
T9974 469-470 CD denotes 5
T9975 470-471 SYM denotes ′
T9976 471-472 HYPH denotes -
T9977 481-482 . denotes .
T9978 482-643 sentence denotes However, it does not necessarily require 3′ end of single-stranded DNA, since Mcm4/6/7 can displace annealing oligonucleotide on a circular single-stranded DNA.
T9979 483-490 RB denotes However
T9980 516-523 VB denotes require
T9981 490-492 , denotes ,
T9982 492-494 PRP denotes it
T9983 495-499 VBZ denotes does
T9984 500-503 RB denotes not
T9985 504-515 RB denotes necessarily
T9986 524-525 CD denotes 3
T9987 527-530 NN denotes end
T9988 525-526 SYM denotes ′
T9989 531-533 IN denotes of
T9990 534-540 JJ denotes single
T9991 541-549 VBN denotes stranded
T9992 540-541 HYPH denotes -
T9993 550-553 NN denotes DNA
T9994 553-555 , denotes ,
T9995 555-560 IN denotes since
T9996 574-582 VB denotes displace
T9997 561-565 NN denotes Mcm4
T9998 565-566 HYPH denotes /
T9999 566-567 CD denotes 6
T10000 567-568 HYPH denotes /
T10001 568-569 CD denotes 7
T10002 570-573 MD denotes can
T10003 583-592 VBG denotes annealing
T10004 593-608 NN denotes oligonucleotide
T10005 609-611 IN denotes on
T10006 612-613 DT denotes a
T10007 639-642 NN denotes DNA
T10008 614-622 JJ denotes circular
T10009 623-629 JJ denotes single
T10010 630-638 VBN denotes stranded
T10011 629-630 HYPH denotes -
T10012 642-643 . denotes .
T10013 643-801 sentence denotes The ability of the mouse Mcm4/6/7 to unwind 3′-extension is shared by the archaeal Mcm helicase but not by Mcm4/6/7 from S.pombe and S.cerevisiae (14,26,27).
T10014 644-647 DT denotes The
T10015 648-655 NN denotes ability
T10016 704-710 VBN denotes shared
T10017 656-658 IN denotes of
T10018 659-662 DT denotes the
T10019 669-673 NN denotes Mcm4
T10020 663-668 NN denotes mouse
T10021 673-674 HYPH denotes /
T10022 674-675 CD denotes 6
T10023 675-676 HYPH denotes /
T10024 676-677 CD denotes 7
T10025 678-680 TO denotes to
T10026 681-687 VB denotes unwind
T10027 688-689 CD denotes 3
T10028 691-700 NN denotes extension
T10029 689-690 SYM denotes ′
T10030 690-691 HYPH denotes -
T10031 701-703 VBZ denotes is
T10032 711-713 IN denotes by
T10033 714-717 DT denotes the
T10034 731-739 NN denotes helicase
T10035 718-726 JJ denotes archaeal
T10036 727-730 NN denotes Mcm
T10037 740-743 CC denotes but
T10038 744-747 RB denotes not
T10039 748-750 IN denotes by
T10040 751-755 NN denotes Mcm4
T10041 755-756 HYPH denotes /
T10042 756-757 CD denotes 6
T10043 757-758 HYPH denotes /
T10044 758-759 CD denotes 7
T10045 760-764 IN denotes from
T10046 765-772 NNP denotes S.pombe
T10047 773-776 CC denotes and
T10048 777-789 NNP denotes S.cerevisiae
T10049 790-791 -LRB- denotes (
T10050 797-799 CD denotes 27
T10051 791-793 CD denotes 14
T10052 793-794 , denotes ,
T10053 794-796 CD denotes 26
T10054 796-797 , denotes ,
T10055 799-800 -RRB- denotes )
T10056 800-801 . denotes .
T10057 801-950 sentence denotes The archaeal Mcm can unwind A-fork[3′] but eukaryotic Mcm4/6/7 cannot, since the former binds to double-stranded DNA but the latter does not (5,27).
T10058 802-805 DT denotes The
T10059 815-818 NN denotes Mcm
T10060 806-814 JJ denotes archaeal
T10061 823-829 VB denotes unwind
T10062 819-822 MD denotes can
T10063 830-831 NN denotes A
T10064 832-836 NN denotes fork
T10065 831-832 HYPH denotes -
T10066 836-837 -LRB- denotes [
T10067 837-838 CD denotes 3
T10068 838-839 SYM denotes ′
T10069 839-840 -RRB- denotes ]
T10070 841-844 CC denotes but
T10071 845-855 JJ denotes eukaryotic
T10072 856-860 NN denotes Mcm4
T10073 865-868 MD denotes can
T10074 860-861 HYPH denotes /
T10075 861-862 CD denotes 6
T10076 862-863 HYPH denotes /
T10077 863-864 CD denotes 7
T10078 868-871 RB denotes not
T10079 871-873 , denotes ,
T10080 873-878 IN denotes since
T10081 890-895 VBZ denotes binds
T10082 879-882 DT denotes the
T10083 883-889 NN denotes former
T10084 896-898 IN denotes to
T10085 899-905 JJ denotes double
T10086 906-914 VBN denotes stranded
T10087 905-906 HYPH denotes -
T10088 915-918 NN denotes DNA
T10089 919-922 CC denotes but
T10090 923-926 DT denotes the
T10091 927-933 JJ denotes latter
T10092 946-948 CD denotes 27
T10093 934-938 VBZ denotes does
T10094 939-942 RB denotes not
T10095 943-944 -LRB- denotes (
T10096 944-945 CD denotes 5
T10097 945-946 , denotes ,
T10098 948-949 -RRB- denotes )
T10099 949-950 . denotes .
T10100 950-1080 sentence denotes While yeast Mcm helicases can translocate on duplex DNA, such activity was not observed with mammalian Mcm4/6/7 (data not shown).
T10101 951-956 IN denotes While
T10102 981-992 VB denotes translocate
T10103 957-962 NN denotes yeast
T10104 963-966 NN denotes Mcm
T10105 967-976 NNS denotes helicases
T10106 977-980 MD denotes can
T10107 1030-1038 VBN denotes observed
T10108 993-995 IN denotes on
T10109 996-1002 NN denotes duplex
T10110 1003-1006 NN denotes DNA
T10111 1006-1008 , denotes ,
T10112 1008-1012 JJ denotes such
T10113 1013-1021 NN denotes activity
T10114 1022-1025 VBD denotes was
T10115 1026-1029 RB denotes not
T10116 1039-1043 IN denotes with
T10117 1044-1053 JJ denotes mammalian
T10118 1054-1058 NN denotes Mcm4
T10119 1058-1059 HYPH denotes /
T10120 1059-1060 CD denotes 6
T10121 1060-1061 HYPH denotes /
T10122 1061-1062 CD denotes 7
T10123 1063-1064 -LRB- denotes (
T10124 1073-1078 VBN denotes shown
T10125 1064-1068 NNS denotes data
T10126 1069-1072 RB denotes not
T10127 1078-1079 -RRB- denotes )
T10128 1079-1080 . denotes .
T10129 1080-1417 sentence denotes Occurrence of AT-rich sequences, with asymmetric distribution of adenine and thymine, near the replication origins, lead us to propose that Mcm may play a role in selection of initiation sites of mammalian DNA replication, and prompted us to examine the ability of sequences from human replication origins to activate Mcm4/6/7 helicase.
T10130 1081-1091 NN denotes Occurrence
T10131 1197-1201 VBP denotes lead
T10132 1092-1094 IN denotes of
T10133 1095-1097 NN denotes AT
T10134 1098-1102 JJ denotes rich
T10135 1097-1098 HYPH denotes -
T10136 1103-1112 NNS denotes sequences
T10137 1112-1114 , denotes ,
T10138 1114-1118 IN denotes with
T10139 1119-1129 JJ denotes asymmetric
T10140 1130-1142 NN denotes distribution
T10141 1143-1145 IN denotes of
T10142 1146-1153 NN denotes adenine
T10143 1154-1157 CC denotes and
T10144 1158-1165 NN denotes thymine
T10145 1165-1167 , denotes ,
T10146 1167-1171 IN denotes near
T10147 1172-1175 DT denotes the
T10148 1188-1195 NNS denotes origins
T10149 1176-1187 NN denotes replication
T10150 1195-1197 , denotes ,
T10151 1202-1204 PRP denotes us
T10152 1205-1207 TO denotes to
T10153 1208-1215 VB denotes propose
T10154 1216-1220 IN denotes that
T10155 1229-1233 VB denotes play
T10156 1221-1224 NNP denotes Mcm
T10157 1225-1228 MD denotes may
T10158 1234-1235 DT denotes a
T10159 1236-1240 NN denotes role
T10160 1241-1243 IN denotes in
T10161 1244-1253 NN denotes selection
T10162 1254-1256 IN denotes of
T10163 1257-1267 NN denotes initiation
T10164 1268-1273 NNS denotes sites
T10165 1274-1276 IN denotes of
T10166 1277-1286 JJ denotes mammalian
T10167 1287-1290 NN denotes DNA
T10168 1291-1302 NN denotes replication
T10169 1302-1304 , denotes ,
T10170 1304-1307 CC denotes and
T10171 1308-1316 VBD denotes prompted
T10172 1317-1319 PRP denotes us
T10173 1320-1322 TO denotes to
T10174 1323-1330 VB denotes examine
T10175 1331-1334 DT denotes the
T10176 1335-1342 NN denotes ability
T10177 1343-1345 IN denotes of
T10178 1346-1355 NNS denotes sequences
T10179 1356-1360 IN denotes from
T10180 1361-1366 JJ denotes human
T10181 1379-1386 NNS denotes origins
T10182 1367-1378 NN denotes replication
T10183 1387-1389 TO denotes to
T10184 1390-1398 VB denotes activate
T10185 1399-1403 NN denotes Mcm4
T10186 1408-1416 NN denotes helicase
T10187 1403-1404 HYPH denotes /
T10188 1404-1405 CD denotes 6
T10189 1405-1406 HYPH denotes /
T10190 1406-1407 CD denotes 7
T10191 1416-1417 . denotes .
T10192 1417-1506 sentence denotes Both lamin-B2 and c-myc origins served as efficient activator for Mcm helicase in vitro.
T10193 1418-1422 CC denotes Both
T10194 1429-1431 NN denotes B2
T10195 1423-1428 NN denotes lamin
T10196 1428-1429 HYPH denotes -
T10197 1442-1449 NNS denotes origins
T10198 1432-1435 CC denotes and
T10199 1436-1437 NN denotes c
T10200 1438-1441 NN denotes myc
T10201 1437-1438 HYPH denotes -
T10202 1450-1456 VBD denotes served
T10203 1457-1459 IN denotes as
T10204 1460-1469 JJ denotes efficient
T10205 1470-1479 NN denotes activator
T10206 1480-1483 IN denotes for
T10207 1484-1487 NN denotes Mcm
T10208 1488-1496 NN denotes helicase
T10209 1497-1499 FW denotes in
T10210 1500-1505 FW denotes vitro
T10211 1505-1506 . denotes .
T10212 1506-1635 sentence denotes Consistent with it, site-specific loading of Mcm in the DNA replication initiation zone of the c-myc was recently reported (33).
T10213 1507-1517 JJ denotes Consistent
T10214 1621-1629 VBN denotes reported
T10215 1518-1522 IN denotes with
T10216 1523-1525 PRP denotes it
T10217 1525-1527 , denotes ,
T10218 1527-1531 NN denotes site
T10219 1532-1540 JJ denotes specific
T10220 1531-1532 HYPH denotes -
T10221 1541-1548 NN denotes loading
T10222 1549-1551 IN denotes of
T10223 1552-1555 NN denotes Mcm
T10224 1556-1558 IN denotes in
T10225 1559-1562 DT denotes the
T10226 1590-1594 NN denotes zone
T10227 1563-1566 NN denotes DNA
T10228 1579-1589 NN denotes initiation
T10229 1567-1578 NN denotes replication
T10230 1595-1597 IN denotes of
T10231 1598-1601 DT denotes the
T10232 1604-1607 NN denotes myc
T10233 1602-1603 NN denotes c
T10234 1603-1604 HYPH denotes -
T10235 1608-1611 VBD denotes was
T10236 1612-1620 RB denotes recently
T10237 1630-1631 -LRB- denotes (
T10238 1631-1633 CD denotes 33
T10239 1633-1634 -RRB- denotes )
T10240 1634-1635 . denotes .
T10241 1635-1753 sentence denotes We have examined in detail the effect of sequence context of the single-stranded DNA on the helicase activity of Mcm.
T10242 1636-1638 PRP denotes We
T10243 1644-1652 VBN denotes examined
T10244 1639-1643 VBP denotes have
T10245 1653-1655 IN denotes in
T10246 1656-1662 NN denotes detail
T10247 1663-1666 DT denotes the
T10248 1667-1673 NN denotes effect
T10249 1674-1676 IN denotes of
T10250 1677-1685 NN denotes sequence
T10251 1686-1693 NN denotes context
T10252 1694-1696 IN denotes of
T10253 1697-1700 DT denotes the
T10254 1717-1720 NN denotes DNA
T10255 1701-1707 JJ denotes single
T10256 1708-1716 VBN denotes stranded
T10257 1707-1708 HYPH denotes -
T10258 1721-1723 IN denotes on
T10259 1724-1727 DT denotes the
T10260 1737-1745 NN denotes activity
T10261 1728-1736 NN denotes helicase
T10262 1746-1748 IN denotes of
T10263 1749-1752 NN denotes Mcm
T10264 1752-1753 . denotes .
T10265 1753-1851 sentence denotes The results indicate that thymine content of 50% is sufficient for the maximum helicase activity.
T10266 1754-1757 DT denotes The
T10267 1758-1765 NNS denotes results
T10268 1766-1774 VBP denotes indicate
T10269 1775-1779 IN denotes that
T10270 1803-1805 VBZ denotes is
T10271 1780-1787 NN denotes thymine
T10272 1788-1795 NN denotes content
T10273 1796-1798 IN denotes of
T10274 1799-1801 CD denotes 50
T10275 1801-1802 NN denotes %
T10276 1806-1816 JJ denotes sufficient
T10277 1817-1820 IN denotes for
T10278 1821-1824 DT denotes the
T10279 1842-1850 NN denotes activity
T10280 1825-1832 JJ denotes maximum
T10281 1833-1841 NN denotes helicase
T10282 1850-1851 . denotes .
T10283 1851-1957 sentence denotes The efficiency of displacement decreased as the thymine content of the 3′-tail dropped to 33% (Figure 6).
T10284 1852-1855 DT denotes The
T10285 1856-1866 NN denotes efficiency
T10286 1883-1892 VBD denotes decreased
T10287 1867-1869 IN denotes of
T10288 1870-1882 NN denotes displacement
T10289 1893-1895 IN denotes as
T10290 1931-1938 VBD denotes dropped
T10291 1896-1899 DT denotes the
T10292 1908-1915 NN denotes content
T10293 1900-1907 NN denotes thymine
T10294 1916-1918 IN denotes of
T10295 1919-1922 DT denotes the
T10296 1926-1930 NN denotes tail
T10297 1923-1924 CD denotes 3
T10298 1924-1925 SYM denotes ′
T10299 1925-1926 HYPH denotes -
T10300 1939-1941 IN denotes to
T10301 1942-1944 CD denotes 33
T10302 1944-1945 NN denotes %
T10303 1946-1947 -LRB- denotes (
T10304 1947-1953 NN denotes Figure
T10305 1954-1955 CD denotes 6
T10306 1955-1956 -RRB- denotes )
T10307 1956-1957 . denotes .
T10308 1957-2101 sentence denotes The stretches of thymine residues may not be necessarily required, since repeats of TC dinucleotides served as a potent activator for Mcm4/6/7.
T10309 1958-1961 DT denotes The
T10310 1962-1971 NNS denotes stretches
T10311 2015-2023 VBN denotes required
T10312 1972-1974 IN denotes of
T10313 1975-1982 NN denotes thymine
T10314 1983-1991 NNS denotes residues
T10315 1992-1995 MD denotes may
T10316 1996-1999 RB denotes not
T10317 2000-2002 VB denotes be
T10318 2003-2014 RB denotes necessarily
T10319 2023-2025 , denotes ,
T10320 2025-2030 IN denotes since
T10321 2059-2065 VBD denotes served
T10322 2031-2038 NNS denotes repeats
T10323 2039-2041 IN denotes of
T10324 2042-2044 NN denotes TC
T10325 2045-2058 NNS denotes dinucleotides
T10326 2066-2068 IN denotes as
T10327 2069-2070 DT denotes a
T10328 2078-2087 NN denotes activator
T10329 2071-2077 JJ denotes potent
T10330 2088-2091 IN denotes for
T10331 2092-2096 NN denotes Mcm4
T10332 2096-2097 HYPH denotes /
T10333 2097-2098 CD denotes 6
T10334 2098-2099 HYPH denotes /
T10335 2099-2100 CD denotes 7
T10336 2100-2101 . denotes .
T10337 2101-2226 sentence denotes We also noticed that the presence of a secondary structure within the single-stranded DNA is inhibitory for helicase action.
T10338 2102-2104 PRP denotes We
T10339 2110-2117 VBD denotes noticed
T10340 2105-2109 RB denotes also
T10341 2118-2122 IN denotes that
T10342 2192-2194 VBZ denotes is
T10343 2123-2126 DT denotes the
T10344 2127-2135 NN denotes presence
T10345 2136-2138 IN denotes of
T10346 2139-2140 DT denotes a
T10347 2151-2160 NN denotes structure
T10348 2141-2150 JJ denotes secondary
T10349 2161-2167 IN denotes within
T10350 2168-2171 DT denotes the
T10351 2188-2191 NN denotes DNA
T10352 2172-2178 JJ denotes single
T10353 2179-2187 VBN denotes stranded
T10354 2178-2179 HYPH denotes -
T10355 2195-2205 JJ denotes inhibitory
T10356 2206-2209 IN denotes for
T10357 2210-2218 NN denotes helicase
T10358 2219-2225 NN denotes action
T10359 2225-2226 . denotes .
T10360 2226-2338 sentence denotes Nuclease footprinting assays indicated that binding was interfered by the secondary structure (data not shown).
T10361 2227-2235 NN denotes Nuclease
T10362 2236-2248 NN denotes footprinting
T10363 2249-2255 NNS denotes assays
T10364 2256-2265 VBD denotes indicated
T10365 2266-2270 IN denotes that
T10366 2283-2293 VBN denotes interfered
T10367 2271-2278 NN denotes binding
T10368 2279-2282 VBD denotes was
T10369 2294-2296 IN denotes by
T10370 2297-2300 DT denotes the
T10371 2311-2320 NN denotes structure
T10372 2301-2310 JJ denotes secondary
T10373 2321-2322 -LRB- denotes (
T10374 2331-2336 VBN denotes shown
T10375 2322-2326 NNS denotes data
T10376 2327-2330 RB denotes not
T10377 2336-2337 -RRB- denotes )
T10378 2337-2338 . denotes .
T10379 2338-2746 sentence denotes Thus, we have concluded that Mcm4/6/7 helicase is most efficiently activated by non-structured single-stranded DNA with thymine content of 50% or more, although significant stimulation is observed also by DNA with less thymine content (Figure 7), suggesting that the sequence specificity for Mcm helicase activation is rather relaxed and that the extent of the activation may depend on the sequence context.
T10380 2339-2343 RB denotes Thus
T10381 2353-2362 VBN denotes concluded
T10382 2343-2345 , denotes ,
T10383 2345-2347 PRP denotes we
T10384 2348-2352 VBP denotes have
T10385 2363-2367 IN denotes that
T10386 2406-2415 VBN denotes activated
T10387 2368-2372 NN denotes Mcm4
T10388 2377-2385 NN denotes helicase
T10389 2372-2373 HYPH denotes /
T10390 2373-2374 CD denotes 6
T10391 2374-2375 HYPH denotes /
T10392 2375-2376 CD denotes 7
T10393 2386-2388 VBZ denotes is
T10394 2389-2393 RBS denotes most
T10395 2394-2405 RB denotes efficiently
T10396 2416-2418 IN denotes by
T10397 2419-2433 JJ denotes non-structured
T10398 2450-2453 NN denotes DNA
T10399 2434-2440 JJ denotes single
T10400 2441-2449 VBN denotes stranded
T10401 2440-2441 HYPH denotes -
T10402 2454-2458 IN denotes with
T10403 2459-2466 NN denotes thymine
T10404 2467-2474 NN denotes content
T10405 2475-2477 IN denotes of
T10406 2478-2480 CD denotes 50
T10407 2480-2481 NN denotes %
T10408 2482-2484 CC denotes or
T10409 2485-2489 JJR denotes more
T10410 2489-2491 , denotes ,
T10411 2491-2499 IN denotes although
T10412 2527-2535 VBN denotes observed
T10413 2500-2511 JJ denotes significant
T10414 2512-2523 NN denotes stimulation
T10415 2524-2526 VBZ denotes is
T10416 2536-2540 RB denotes also
T10417 2541-2543 IN denotes by
T10418 2544-2547 NN denotes DNA
T10419 2548-2552 IN denotes with
T10420 2553-2557 JJR denotes less
T10421 2566-2573 NN denotes content
T10422 2558-2565 NN denotes thymine
T10423 2574-2575 -LRB- denotes (
T10424 2575-2581 NN denotes Figure
T10425 2582-2583 CD denotes 7
T10426 2583-2584 -RRB- denotes )
T10427 2584-2586 , denotes ,
T10428 2586-2596 VBG denotes suggesting
T10429 2597-2601 IN denotes that
T10430 2655-2657 VBZ denotes is
T10431 2602-2605 DT denotes the
T10432 2615-2626 NN denotes specificity
T10433 2606-2614 NN denotes sequence
T10434 2627-2630 IN denotes for
T10435 2631-2634 NN denotes Mcm
T10436 2635-2643 NN denotes helicase
T10437 2644-2654 NN denotes activation
T10438 2658-2664 RB denotes rather
T10439 2665-2672 JJ denotes relaxed
T10440 2673-2676 CC denotes and
T10441 2677-2681 IN denotes that
T10442 2715-2721 VB denotes depend
T10443 2682-2685 DT denotes the
T10444 2686-2692 NN denotes extent
T10445 2693-2695 IN denotes of
T10446 2696-2699 DT denotes the
T10447 2700-2710 NN denotes activation
T10448 2711-2714 MD denotes may
T10449 2722-2724 IN denotes on
T10450 2725-2728 DT denotes the
T10451 2738-2745 NN denotes context
T10452 2729-2737 NN denotes sequence
T10453 2745-2746 . denotes .
T10454 2746-3044 sentence denotes This would be reasonable given the flexibility and differential regulation of site selection for initiation of DNA replication during development or in various cell types, as well as the variability in initiation potential of each replication origin on the genome even within the single cell type.
T10455 2747-2751 DT denotes This
T10456 2758-2760 VB denotes be
T10457 2752-2757 MD denotes would
T10458 2761-2771 JJ denotes reasonable
T10459 2772-2777 VBN denotes given
T10460 2778-2781 DT denotes the
T10461 2782-2793 NN denotes flexibility
T10462 2794-2797 CC denotes and
T10463 2798-2810 JJ denotes differential
T10464 2811-2821 NN denotes regulation
T10465 2822-2824 IN denotes of
T10466 2825-2829 NN denotes site
T10467 2830-2839 NN denotes selection
T10468 2840-2843 IN denotes for
T10469 2844-2854 NN denotes initiation
T10470 2855-2857 IN denotes of
T10471 2858-2861 NN denotes DNA
T10472 2862-2873 NN denotes replication
T10473 2874-2880 IN denotes during
T10474 2881-2892 NN denotes development
T10475 2893-2895 CC denotes or
T10476 2896-2898 IN denotes in
T10477 2899-2906 JJ denotes various
T10478 2912-2917 NNS denotes types
T10479 2907-2911 NN denotes cell
T10480 2917-2919 , denotes ,
T10481 2919-2921 RB denotes as
T10482 2927-2929 IN denotes as
T10483 2922-2926 RB denotes well
T10484 2930-2933 DT denotes the
T10485 2934-2945 NN denotes variability
T10486 2946-2948 IN denotes in
T10487 2949-2959 NN denotes initiation
T10488 2960-2969 NN denotes potential
T10489 2970-2972 IN denotes of
T10490 2973-2977 DT denotes each
T10491 2990-2996 NN denotes origin
T10492 2978-2989 NN denotes replication
T10493 2997-2999 IN denotes on
T10494 3000-3003 DT denotes the
T10495 3004-3010 NN denotes genome
T10496 3011-3015 RB denotes even
T10497 3016-3022 IN denotes within
T10498 3023-3026 DT denotes the
T10499 3039-3043 NN denotes type
T10500 3027-3033 JJ denotes single
T10501 3034-3038 NN denotes cell
T10502 3043-3044 . denotes .
R6455 T9856 T9857 nmod Substrate,requirement
R6456 T9858 T9856 cc and,Substrate
R6457 T9859 T9856 conj sequence,Substrate
R6458 T9860 T9857 prep for,requirement
R6459 T9861 T9862 nmod Mcm4,activation
R6460 T9862 T9860 pobj activation,for
R6461 T9863 T9861 punct /,Mcm4
R6462 T9864 T9861 nummod 6,Mcm4
R6463 T9865 T9861 punct /,Mcm4
R6464 T9866 T9861 nummod 7,Mcm4
R6465 T9867 T9862 compound helicase,activation
R6466 T9869 T9870 compound DNA,binding
R6467 T9870 T9871 compound binding,assays
R6468 T9871 T9872 nsubj assays,indicate
R6469 T9873 T9874 mark that,binds
R6470 T9874 T9872 ccomp binds,indicate
R6471 T9875 T9874 nsubj Mcm4,binds
R6472 T9876 T9875 punct /,Mcm4
R6473 T9877 T9875 nummod 6,Mcm4
R6474 T9878 T9875 punct /,Mcm4
R6475 T9879 T9875 nummod 7,Mcm4
R6476 T9880 T9874 prep to,binds
R6477 T9881 T9882 det those,substrates
R6478 T9882 T9880 pobj substrates,to
R6479 T9883 T9882 acl containing,substrates
R6480 T9884 T9885 amod single,stranded
R6481 T9885 T9887 amod stranded,regions
R6482 T9886 T9885 punct -,stranded
R6483 T9887 T9883 dobj regions,containing
R6484 T9888 T9887 compound DNA,regions
R6485 T9889 T9874 advmod regardless,binds
R6486 T9890 T9889 prep of,regardless
R6487 T9891 T9892 det the,presence
R6488 T9892 T9890 pobj presence,of
R6489 T9893 T9892 cc or,presence
R6490 T9894 T9892 conj absence,presence
R6491 T9895 T9892 prep of,presence
R6492 T9896 T9897 amod single,stranded
R6493 T9897 T9899 amod stranded,end
R6494 T9898 T9897 punct -,stranded
R6495 T9899 T9895 pobj end,of
R6496 T9900 T9899 nummod 3,end
R6497 T9901 T9900 punct ′,3
R6498 T9902 T9900 cc or,3
R6499 T9903 T9900 conj 5,3
R6500 T9904 T9903 punct ′,5
R6501 T9905 T9872 punct .,indicate
R6502 T9907 T9908 nsubj Unwinding,depends
R6503 T9909 T9907 prep of,Unwinding
R6504 T9910 T9911 det the,DNA
R6505 T9911 T9909 pobj DNA,of
R6506 T9912 T9911 compound duplex,DNA
R6507 T9913 T9908 prep on,depends
R6508 T9914 T9913 pobj translocation,on
R6509 T9915 T9914 prep of,translocation
R6510 T9916 T9917 amod single,stranded
R6511 T9917 T9919 amod stranded,DNA
R6512 T9918 T9917 punct -,stranded
R6513 T9919 T9915 pobj DNA,of
R6514 T9920 T9914 prep from,translocation
R6515 T9921 T9920 pobj 3,from
R6516 T9922 T9921 punct ′,3
R6517 T9923 T9920 prep to,from
R6518 T9924 T9923 pobj 5,to
R6519 T9925 T9924 punct ′,5
R6520 T9926 T9920 pobj direction,from
R6521 T9927 T9908 punct .,depends
R6522 T9929 T9930 nsubjpass This,shown
R6523 T9931 T9930 auxpass is,shown
R6524 T9932 T9933 advmod most,clearly
R6525 T9933 T9930 advmod clearly,shown
R6526 T9934 T9930 prep by,shown
R6527 T9935 T9936 poss its,action
R6528 T9936 T9934 pobj action,by
R6529 T9937 T9936 compound helicase,action
R6530 T9938 T9936 prep on,action
R6531 T9939 T9940 nmod A,fork
R6532 T9940 T9942 nmod fork,extension
R6533 T9941 T9940 punct -,fork
R6534 T9942 T9938 pobj extension,on
R6535 T9943 T9940 punct [,fork
R6536 T9944 T9940 appos 5,fork
R6537 T9945 T9944 punct ′,5
R6538 T9946 T9944 punct ],5
R6539 T9947 T9944 cc and,5
R6540 T9948 T9944 conj 3,5
R6541 T9949 T9948 punct ′,3
R6542 T9950 T9942 punct -,extension
R6543 T9951 T9938 cc but,on
R6544 T9952 T9951 neg not,but
R6545 T9953 T9938 conj on,on
R6546 T9954 T9955 nmod A,fork
R6547 T9955 T9957 nmod fork,extension
R6548 T9956 T9955 punct -,fork
R6549 T9957 T9953 pobj extension,on
R6550 T9958 T9955 punct [,fork
R6551 T9959 T9955 nummod 3,fork
R6552 T9960 T9955 punct ′,fork
R6553 T9961 T9955 punct ],fork
R6554 T9962 T9955 punct ", ",fork
R6555 T9963 T9964 compound A,fork
R6556 T9964 T9955 conj fork,fork
R6557 T9965 T9964 punct -,fork
R6558 T9966 T9964 punct [,fork
R6559 T9967 T9964 appos 3,fork
R6560 T9968 T9967 punct ′,3
R6561 T9969 T9967 punct ",",3
R6562 T9970 T9967 appos 5,3
R6563 T9971 T9970 punct ′,5
R6564 T9972 T9964 punct ],fork
R6565 T9973 T9964 cc nor,fork
R6566 T9974 T9964 conj 5,fork
R6567 T9975 T9974 punct ′,5
R6568 T9976 T9957 punct -,extension
R6569 T9977 T9930 punct .,shown
R6570 T9979 T9980 advmod However,require
R6571 T9981 T9980 punct ", ",require
R6572 T9982 T9980 nsubj it,require
R6573 T9983 T9980 aux does,require
R6574 T9984 T9980 neg not,require
R6575 T9985 T9980 advmod necessarily,require
R6576 T9986 T9987 nummod 3,end
R6577 T9987 T9980 dobj end,require
R6578 T9988 T9986 punct ′,3
R6579 T9989 T9987 prep of,end
R6580 T9990 T9991 amod single,stranded
R6581 T9991 T9993 amod stranded,DNA
R6582 T9992 T9991 punct -,stranded
R6583 T9993 T9989 pobj DNA,of
R6584 T9994 T9980 punct ", ",require
R6585 T9995 T9996 mark since,displace
R6586 T9996 T9980 advcl displace,require
R6587 T9997 T9996 nsubj Mcm4,displace
R6588 T9998 T9997 punct /,Mcm4
R6589 T9999 T9997 nummod 6,Mcm4
R6590 T10000 T9997 punct /,Mcm4
R6591 T10001 T9997 nummod 7,Mcm4
R6592 T10002 T9996 aux can,displace
R6593 T10003 T10004 amod annealing,oligonucleotide
R6594 T10004 T9996 dobj oligonucleotide,displace
R6595 T10005 T9996 prep on,displace
R6596 T10006 T10007 det a,DNA
R6597 T10007 T10005 pobj DNA,on
R6598 T10008 T10007 amod circular,DNA
R6599 T10009 T10010 amod single,stranded
R6600 T10010 T10007 amod stranded,DNA
R6601 T10011 T10010 punct -,stranded
R6602 T10012 T9980 punct .,require
R6603 T10014 T10015 det The,ability
R6604 T10015 T10016 nsubjpass ability,shared
R6605 T10017 T10015 prep of,ability
R6606 T10018 T10019 det the,Mcm4
R6607 T10019 T10017 pobj Mcm4,of
R6608 T10020 T10019 compound mouse,Mcm4
R6609 T10021 T10019 punct /,Mcm4
R6610 T10022 T10019 nummod 6,Mcm4
R6611 T10023 T10019 punct /,Mcm4
R6612 T10024 T10019 nummod 7,Mcm4
R6613 T10025 T10026 aux to,unwind
R6614 T10026 T10015 acl unwind,ability
R6615 T10027 T10028 nummod 3,extension
R6616 T10028 T10026 dobj extension,unwind
R6617 T10029 T10027 punct ′,3
R6618 T10030 T10028 punct -,extension
R6619 T10031 T10016 auxpass is,shared
R6620 T10032 T10016 prep by,shared
R6621 T10033 T10034 det the,helicase
R6622 T10034 T10032 pobj helicase,by
R6623 T10035 T10034 amod archaeal,helicase
R6624 T10036 T10034 compound Mcm,helicase
R6625 T10037 T10032 cc but,by
R6626 T10038 T10037 neg not,but
R6627 T10039 T10032 conj by,by
R6628 T10040 T10039 pobj Mcm4,by
R6629 T10041 T10040 punct /,Mcm4
R6630 T10042 T10040 nummod 6,Mcm4
R6631 T10043 T10040 punct /,Mcm4
R6632 T10044 T10040 nummod 7,Mcm4
R6633 T10045 T10040 prep from,Mcm4
R6634 T10046 T10045 pobj S.pombe,from
R6635 T10047 T10046 cc and,S.pombe
R6636 T10048 T10046 conj S.cerevisiae,S.pombe
R6637 T10049 T10050 punct (,27
R6638 T10050 T10016 parataxis 27,shared
R6639 T10051 T10050 nummod 14,27
R6640 T10052 T10050 punct ",",27
R6641 T10053 T10050 nummod 26,27
R6642 T10054 T10050 punct ",",27
R6643 T10055 T10050 punct ),27
R6644 T10056 T10016 punct .,shared
R6645 T10058 T10059 det The,Mcm
R6646 T10059 T10061 nsubj Mcm,unwind
R6647 T10060 T10059 amod archaeal,Mcm
R6648 T10062 T10061 aux can,unwind
R6649 T10063 T10064 compound A,fork
R6650 T10064 T10061 dobj fork,unwind
R6651 T10065 T10064 punct -,fork
R6652 T10066 T10064 punct [,fork
R6653 T10067 T10064 nummod 3,fork
R6654 T10068 T10064 punct ′,fork
R6655 T10069 T10061 punct ],unwind
R6656 T10070 T10061 cc but,unwind
R6657 T10071 T10072 amod eukaryotic,Mcm4
R6658 T10072 T10073 nsubj Mcm4,can
R6659 T10073 T10061 conj can,unwind
R6660 T10074 T10072 punct /,Mcm4
R6661 T10075 T10072 nummod 6,Mcm4
R6662 T10076 T10072 punct /,Mcm4
R6663 T10077 T10072 nummod 7,Mcm4
R6664 T10078 T10073 neg not,can
R6665 T10079 T10061 punct ", ",unwind
R6666 T10080 T10081 mark since,binds
R6667 T10081 T10061 advcl binds,unwind
R6668 T10082 T10083 det the,former
R6669 T10083 T10081 nsubj former,binds
R6670 T10084 T10081 prep to,binds
R6671 T10085 T10086 amod double,stranded
R6672 T10086 T10088 amod stranded,DNA
R6673 T10087 T10086 punct -,stranded
R6674 T10088 T10084 pobj DNA,to
R6675 T10089 T10081 cc but,binds
R6676 T10090 T10091 det the,latter
R6677 T10091 T10092 nsubj latter,27
R6678 T10092 T10081 conj 27,binds
R6679 T10093 T10092 aux does,27
R6680 T10094 T10092 neg not,27
R6681 T10095 T10092 punct (,27
R6682 T10096 T10092 nummod 5,27
R6683 T10097 T10092 punct ",",27
R6684 T10098 T10092 punct ),27
R6685 T10099 T10061 punct .,unwind
R6686 T10101 T10102 mark While,translocate
R6687 T10102 T10107 advcl translocate,observed
R6688 T10103 T10104 compound yeast,Mcm
R6689 T10104 T10105 compound Mcm,helicases
R6690 T10105 T10102 nsubj helicases,translocate
R6691 T10106 T10102 aux can,translocate
R6692 T10108 T10102 prep on,translocate
R6693 T10109 T10110 compound duplex,DNA
R6694 T10110 T10108 pobj DNA,on
R6695 T10111 T10107 punct ", ",observed
R6696 T10112 T10113 amod such,activity
R6697 T10113 T10107 nsubjpass activity,observed
R6698 T10114 T10107 auxpass was,observed
R6699 T10115 T10107 neg not,observed
R6700 T10116 T10107 prep with,observed
R6701 T10117 T10118 amod mammalian,Mcm4
R6702 T10118 T10116 pobj Mcm4,with
R6703 T10119 T10118 punct /,Mcm4
R6704 T10120 T10118 nummod 6,Mcm4
R6705 T10121 T10118 punct /,Mcm4
R6706 T10122 T10118 nummod 7,Mcm4
R6707 T10123 T10124 punct (,shown
R6708 T10124 T10107 parataxis shown,observed
R6709 T10125 T10124 nsubj data,shown
R6710 T10126 T10124 neg not,shown
R6711 T10127 T10124 punct ),shown
R6712 T10128 T10107 punct .,observed
R6713 T10130 T10131 nsubj Occurrence,lead
R6714 T10132 T10130 prep of,Occurrence
R6715 T10133 T10134 npadvmod AT,rich
R6716 T10134 T10136 amod rich,sequences
R6717 T10135 T10134 punct -,rich
R6718 T10136 T10132 pobj sequences,of
R6719 T10137 T10130 punct ", ",Occurrence
R6720 T10138 T10130 prep with,Occurrence
R6721 T10139 T10140 amod asymmetric,distribution
R6722 T10140 T10138 pobj distribution,with
R6723 T10141 T10140 prep of,distribution
R6724 T10142 T10141 pobj adenine,of
R6725 T10143 T10142 cc and,adenine
R6726 T10144 T10142 conj thymine,adenine
R6727 T10145 T10140 punct ", ",distribution
R6728 T10146 T10140 prep near,distribution
R6729 T10147 T10148 det the,origins
R6730 T10148 T10146 pobj origins,near
R6731 T10149 T10148 compound replication,origins
R6732 T10150 T10131 punct ", ",lead
R6733 T10151 T10131 dobj us,lead
R6734 T10152 T10153 aux to,propose
R6735 T10153 T10131 xcomp propose,lead
R6736 T10154 T10155 mark that,play
R6737 T10155 T10153 ccomp play,propose
R6738 T10156 T10155 nsubj Mcm,play
R6739 T10157 T10155 aux may,play
R6740 T10158 T10159 det a,role
R6741 T10159 T10155 dobj role,play
R6742 T10160 T10155 prep in,play
R6743 T10161 T10160 pobj selection,in
R6744 T10162 T10161 prep of,selection
R6745 T10163 T10164 compound initiation,sites
R6746 T10164 T10162 pobj sites,of
R6747 T10165 T10164 prep of,sites
R6748 T10166 T10167 amod mammalian,DNA
R6749 T10167 T10168 compound DNA,replication
R6750 T10168 T10165 pobj replication,of
R6751 T10169 T10131 punct ", ",lead
R6752 T10170 T10131 cc and,lead
R6753 T10171 T10131 conj prompted,lead
R6754 T10172 T10171 dobj us,prompted
R6755 T10173 T10174 aux to,examine
R6756 T10174 T10171 xcomp examine,prompted
R6757 T10175 T10176 det the,ability
R6758 T10176 T10174 dobj ability,examine
R6759 T10177 T10176 prep of,ability
R6760 T10178 T10177 pobj sequences,of
R6761 T10179 T10178 prep from,sequences
R6762 T10180 T10181 amod human,origins
R6763 T10181 T10179 pobj origins,from
R6764 T10182 T10181 compound replication,origins
R6765 T10183 T10184 aux to,activate
R6766 T10184 T10176 acl activate,ability
R6767 T10185 T10186 nmod Mcm4,helicase
R6768 T10186 T10184 dobj helicase,activate
R6769 T10187 T10185 punct /,Mcm4
R6770 T10188 T10185 nummod 6,Mcm4
R6771 T10189 T10185 punct /,Mcm4
R6772 T10190 T10185 nummod 7,Mcm4
R6773 T10191 T10131 punct .,lead
R6774 T10193 T10194 preconj Both,B2
R6775 T10194 T10197 nmod B2,origins
R6776 T10195 T10194 nmod lamin,B2
R6777 T10196 T10194 punct -,B2
R6778 T10197 T10202 nsubj origins,served
R6779 T10198 T10194 cc and,B2
R6780 T10199 T10200 compound c,myc
R6781 T10200 T10194 conj myc,B2
R6782 T10201 T10200 punct -,myc
R6783 T10203 T10202 prep as,served
R6784 T10204 T10205 amod efficient,activator
R6785 T10205 T10203 pobj activator,as
R6786 T10206 T10205 prep for,activator
R6787 T10207 T10208 compound Mcm,helicase
R6788 T10208 T10206 pobj helicase,for
R6789 T10209 T10210 advmod in,vitro
R6790 T10210 T10202 advmod vitro,served
R6791 T10211 T10202 punct .,served
R6792 T10213 T10214 advcl Consistent,reported
R6793 T10215 T10213 prep with,Consistent
R6794 T10216 T10215 pobj it,with
R6795 T10217 T10214 punct ", ",reported
R6796 T10218 T10219 npadvmod site,specific
R6797 T10219 T10221 amod specific,loading
R6798 T10220 T10219 punct -,specific
R6799 T10221 T10214 nsubjpass loading,reported
R6800 T10222 T10221 prep of,loading
R6801 T10223 T10222 pobj Mcm,of
R6802 T10224 T10221 prep in,loading
R6803 T10225 T10226 det the,zone
R6804 T10226 T10224 pobj zone,in
R6805 T10227 T10228 compound DNA,initiation
R6806 T10228 T10226 compound initiation,zone
R6807 T10229 T10228 compound replication,initiation
R6808 T10230 T10226 prep of,zone
R6809 T10231 T10232 det the,myc
R6810 T10232 T10230 pobj myc,of
R6811 T10233 T10232 compound c,myc
R6812 T10234 T10232 punct -,myc
R6813 T10235 T10214 auxpass was,reported
R6814 T10236 T10214 advmod recently,reported
R6815 T10237 T10238 punct (,33
R6816 T10238 T10214 parataxis 33,reported
R6817 T10239 T10238 punct ),33
R6818 T10240 T10214 punct .,reported
R6819 T10242 T10243 nsubj We,examined
R6820 T10244 T10243 aux have,examined
R6821 T10245 T10243 prep in,examined
R6822 T10246 T10245 pobj detail,in
R6823 T10247 T10248 det the,effect
R6824 T10248 T10243 dobj effect,examined
R6825 T10249 T10248 prep of,effect
R6826 T10250 T10251 compound sequence,context
R6827 T10251 T10249 pobj context,of
R6828 T10252 T10251 prep of,context
R6829 T10253 T10254 det the,DNA
R6830 T10254 T10252 pobj DNA,of
R6831 T10255 T10256 amod single,stranded
R6832 T10256 T10254 amod stranded,DNA
R6833 T10257 T10256 punct -,stranded
R6834 T10258 T10248 prep on,effect
R6835 T10259 T10260 det the,activity
R6836 T10260 T10258 pobj activity,on
R6837 T10261 T10260 compound helicase,activity
R6838 T10262 T10260 prep of,activity
R6839 T10263 T10262 pobj Mcm,of
R6840 T10264 T10243 punct .,examined
R6841 T10266 T10267 det The,results
R6842 T10267 T10268 nsubj results,indicate
R6843 T10269 T10270 mark that,is
R6844 T10270 T10268 ccomp is,indicate
R6845 T10271 T10272 compound thymine,content
R6846 T10272 T10270 nsubj content,is
R6847 T10273 T10272 prep of,content
R6848 T10274 T10275 nummod 50,%
R6849 T10275 T10273 pobj %,of
R6850 T10276 T10270 acomp sufficient,is
R6851 T10277 T10276 prep for,sufficient
R6852 T10278 T10279 det the,activity
R6853 T10279 T10277 pobj activity,for
R6854 T10280 T10279 amod maximum,activity
R6855 T10281 T10279 compound helicase,activity
R6856 T10282 T10268 punct .,indicate
R6857 T10284 T10285 det The,efficiency
R6858 T10285 T10286 nsubj efficiency,decreased
R6859 T10287 T10285 prep of,efficiency
R6860 T10288 T10287 pobj displacement,of
R6861 T10289 T10290 mark as,dropped
R6862 T10290 T10286 advcl dropped,decreased
R6863 T10291 T10292 det the,content
R6864 T10292 T10290 nsubj content,dropped
R6865 T10293 T10292 compound thymine,content
R6866 T10294 T10292 prep of,content
R6867 T10295 T10296 det the,tail
R6868 T10296 T10294 pobj tail,of
R6869 T10297 T10296 nummod 3,tail
R6870 T10298 T10297 punct ′,3
R6871 T10299 T10296 punct -,tail
R6872 T10300 T10290 prep to,dropped
R6873 T10301 T10302 nummod 33,%
R6874 T10302 T10300 pobj %,to
R6875 T10303 T10304 punct (,Figure
R6876 T10304 T10290 parataxis Figure,dropped
R6877 T10305 T10304 nummod 6,Figure
R6878 T10306 T10304 punct ),Figure
R6879 T10307 T10286 punct .,decreased
R6880 T10309 T10310 det The,stretches
R6881 T10310 T10311 nsubjpass stretches,required
R6882 T10312 T10310 prep of,stretches
R6883 T10313 T10314 compound thymine,residues
R6884 T10314 T10312 pobj residues,of
R6885 T10315 T10311 aux may,required
R6886 T10316 T10311 neg not,required
R6887 T10317 T10311 auxpass be,required
R6888 T10318 T10311 advmod necessarily,required
R6889 T10319 T10311 punct ", ",required
R6890 T10320 T10321 mark since,served
R6891 T10321 T10311 advcl served,required
R6892 T10322 T10321 nsubj repeats,served
R6893 T10323 T10322 prep of,repeats
R6894 T10324 T10325 compound TC,dinucleotides
R6895 T10325 T10323 pobj dinucleotides,of
R6896 T10326 T10321 prep as,served
R6897 T10327 T10328 det a,activator
R6898 T10328 T10326 pobj activator,as
R6899 T10329 T10328 amod potent,activator
R6900 T10330 T10328 prep for,activator
R6901 T10331 T10330 pobj Mcm4,for
R6902 T10332 T10331 punct /,Mcm4
R6903 T10333 T10331 nummod 6,Mcm4
R6904 T10334 T10331 punct /,Mcm4
R6905 T10335 T10331 nummod 7,Mcm4
R6906 T10336 T10311 punct .,required
R6907 T10338 T10339 nsubj We,noticed
R6908 T10340 T10339 advmod also,noticed
R6909 T10341 T10342 mark that,is
R6910 T10342 T10339 ccomp is,noticed
R6911 T10343 T10344 det the,presence
R6912 T10344 T10342 nsubj presence,is
R6913 T10345 T10344 prep of,presence
R6914 T10346 T10347 det a,structure
R6915 T10347 T10345 pobj structure,of
R6916 T10348 T10347 amod secondary,structure
R6917 T10349 T10347 prep within,structure
R6918 T10350 T10351 det the,DNA
R6919 T10351 T10349 pobj DNA,within
R6920 T10352 T10353 amod single,stranded
R6921 T10353 T10351 amod stranded,DNA
R6922 T10354 T10353 punct -,stranded
R6923 T10355 T10342 acomp inhibitory,is
R6924 T10356 T10355 prep for,inhibitory
R6925 T10357 T10358 compound helicase,action
R6926 T10358 T10356 pobj action,for
R6927 T10359 T10339 punct .,noticed
R6928 T10361 T10362 compound Nuclease,footprinting
R6929 T10362 T10363 compound footprinting,assays
R6930 T10363 T10364 nsubj assays,indicated
R6931 T10365 T10366 mark that,interfered
R6932 T10366 T10364 ccomp interfered,indicated
R6933 T10367 T10366 nsubjpass binding,interfered
R6934 T10368 T10366 auxpass was,interfered
R6935 T10369 T10366 agent by,interfered
R6936 T10370 T10371 det the,structure
R6937 T10371 T10369 pobj structure,by
R6938 T10372 T10371 amod secondary,structure
R6939 T10373 T10374 punct (,shown
R6940 T10374 T10366 parataxis shown,interfered
R6941 T10375 T10374 nsubj data,shown
R6942 T10376 T10374 neg not,shown
R6943 T10377 T10374 punct ),shown
R6944 T10378 T10364 punct .,indicated
R6945 T10380 T10381 advmod Thus,concluded
R6946 T10382 T10381 punct ", ",concluded
R6947 T10383 T10381 nsubj we,concluded
R6948 T10384 T10381 aux have,concluded
R6949 T10385 T10386 mark that,activated
R6950 T10386 T10381 ccomp activated,concluded
R6951 T10387 T10388 nmod Mcm4,helicase
R6952 T10388 T10386 nsubjpass helicase,activated
R6953 T10389 T10387 punct /,Mcm4
R6954 T10390 T10387 nummod 6,Mcm4
R6955 T10391 T10387 punct /,Mcm4
R6956 T10392 T10387 nummod 7,Mcm4
R6957 T10393 T10386 auxpass is,activated
R6958 T10394 T10395 advmod most,efficiently
R6959 T10395 T10386 advmod efficiently,activated
R6960 T10396 T10386 agent by,activated
R6961 T10397 T10398 amod non-structured,DNA
R6962 T10398 T10396 pobj DNA,by
R6963 T10399 T10400 amod single,stranded
R6964 T10400 T10398 amod stranded,DNA
R6965 T10401 T10400 punct -,stranded
R6966 T10402 T10398 prep with,DNA
R6967 T10403 T10404 compound thymine,content
R6968 T10404 T10402 pobj content,with
R6969 T10405 T10404 prep of,content
R6970 T10406 T10407 nummod 50,%
R6971 T10407 T10405 pobj %,of
R6972 T10408 T10409 cc or,more
R6973 T10409 T10407 nummod more,%
R6974 T10410 T10386 punct ", ",activated
R6975 T10411 T10412 mark although,observed
R6976 T10412 T10386 advcl observed,activated
R6977 T10413 T10414 amod significant,stimulation
R6978 T10414 T10412 nsubjpass stimulation,observed
R6979 T10415 T10412 auxpass is,observed
R6980 T10416 T10412 advmod also,observed
R6981 T10417 T10412 agent by,observed
R6982 T10418 T10417 pobj DNA,by
R6983 T10419 T10418 prep with,DNA
R6984 T10420 T10421 amod less,content
R6985 T10421 T10419 pobj content,with
R6986 T10422 T10421 compound thymine,content
R6987 T10423 T10424 punct (,Figure
R6988 T10424 T10418 parataxis Figure,DNA
R6989 T10425 T10424 nummod 7,Figure
R6990 T10426 T10424 punct ),Figure
R6991 T10427 T10412 punct ", ",observed
R6992 T10428 T10412 advcl suggesting,observed
R6993 T10429 T10430 mark that,is
R6994 T10430 T10428 advcl is,suggesting
R6995 T10431 T10432 det the,specificity
R6996 T10432 T10430 nsubj specificity,is
R6997 T10433 T10432 compound sequence,specificity
R6998 T10434 T10432 prep for,specificity
R6999 T10435 T10436 compound Mcm,helicase
R7000 T10436 T10437 compound helicase,activation
R7001 T10437 T10434 pobj activation,for
R7002 T10438 T10439 advmod rather,relaxed
R7003 T10439 T10430 acomp relaxed,is
R7004 T10440 T10430 cc and,is
R7005 T10441 T10442 mark that,depend
R7006 T10442 T10430 conj depend,is
R7007 T10443 T10444 det the,extent
R7008 T10444 T10442 nsubj extent,depend
R7009 T10445 T10444 prep of,extent
R7010 T10446 T10447 det the,activation
R7011 T10447 T10445 pobj activation,of
R7012 T10448 T10442 aux may,depend
R7013 T10449 T10442 prep on,depend
R7014 T10450 T10451 det the,context
R7015 T10451 T10449 pobj context,on
R7016 T10452 T10451 compound sequence,context
R7017 T10453 T10381 punct .,concluded
R7018 T10455 T10456 nsubj This,be
R7019 T10457 T10456 aux would,be
R7020 T10458 T10456 acomp reasonable,be
R7021 T10459 T10456 prep given,be
R7022 T10460 T10461 det the,flexibility
R7023 T10461 T10459 pobj flexibility,given
R7024 T10462 T10461 cc and,flexibility
R7025 T10463 T10464 amod differential,regulation
R7026 T10464 T10461 conj regulation,flexibility
R7027 T10465 T10461 prep of,flexibility
R7028 T10466 T10467 compound site,selection
R7029 T10467 T10465 pobj selection,of
R7030 T10468 T10461 prep for,flexibility
R7031 T10469 T10468 pobj initiation,for
R7032 T10470 T10469 prep of,initiation
R7033 T10471 T10472 compound DNA,replication
R7034 T10472 T10470 pobj replication,of
R7035 T10473 T10469 prep during,initiation
R7036 T10474 T10473 pobj development,during
R7037 T10475 T10468 cc or,for
R7038 T10476 T10468 conj in,for
R7039 T10477 T10478 amod various,types
R7040 T10478 T10476 pobj types,in
R7041 T10479 T10478 compound cell,types
R7042 T10480 T10461 punct ", ",flexibility
R7043 T10481 T10482 advmod as,as
R7044 T10482 T10461 cc as,flexibility
R7045 T10483 T10482 advmod well,as
R7046 T10484 T10485 det the,variability
R7047 T10485 T10461 conj variability,flexibility
R7048 T10486 T10485 prep in,variability
R7049 T10487 T10488 compound initiation,potential
R7050 T10488 T10486 pobj potential,in
R7051 T10489 T10488 prep of,potential
R7052 T10490 T10491 det each,origin
R7053 T10491 T10489 pobj origin,of
R7054 T10492 T10491 compound replication,origin
R7055 T10493 T10491 prep on,origin
R7056 T10494 T10495 det the,genome
R7057 T10495 T10493 pobj genome,on
R7058 T10496 T10497 advmod even,within
R7059 T10497 T10485 prep within,variability
R7060 T10498 T10499 det the,type
R7061 T10499 T10497 pobj type,within
R7062 T10500 T10499 amod single,type
R7063 T10501 T10499 compound cell,type
R7064 T10502 T10456 punct .,be

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T9739 14-22 SO_EXT:biological_sequence denotes sequence
T9740 39-43 PR_EXT:000010246 denotes Mcm4
T9741 39-47 GO:0097373 denotes Mcm4/6/7
T9742 48-56 GO_EXT:0004386 denotes helicase
T9743 68-71 CHEBI_SO_EXT:DNA denotes DNA
T9744 72-79 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T9745 101-105 PR_EXT:000010246 denotes Mcm4
T9746 101-109 GO:0097373 denotes Mcm4/6/7
T9747 110-115 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T9748 147-166 CHEBI_SO_EXT:single_stranded_DNA denotes single-stranded DNA
T9749 216-231 SO:0000984 denotes single-stranded
T9750 246-258 _FRAGMENT denotes Unwinding of
T9751 263-273 GO:0032508 denotes duplex DNA
T9752 263-273 CHEBI_SO_EXT:double_stranded_DNA denotes duplex DNA
T9753 285-298 GO_EXT:biological_translocation_entity_or_process denotes translocation
T9754 302-321 CHEBI_SO_EXT:single_stranded_DNA denotes single-stranded DNA
T9755 381-389 GO_EXT:0004386 denotes helicase
T9756 402-406 GO:0005657 denotes fork
T9757 415-427 GO:0006272 denotes 3′-extension
T9758 441-445 GO:0005657 denotes fork
T9759 453-457 GO:0005657 denotes fork
T9760 469-481 GO:0006273 denotes 5′-extension
T9761 534-553 CHEBI_SO_EXT:single_stranded_DNA denotes single-stranded DNA
T9762 561-565 PR_EXT:000010246 denotes Mcm4
T9763 561-569 GO:0097373 denotes Mcm4/6/7
T9764 583-592 GO:0097617 denotes annealing
T9765 593-608 CHEBI_SO_EXT:oligonucleotide denotes oligonucleotide
T9766 614-622 SO:0000988 denotes circular
T9767 623-642 CHEBI_SO_EXT:single_stranded_DNA denotes single-stranded DNA
T9768 663-668 NCBITaxon:10088 denotes mouse
T9769 669-673 PR_EXT:000010246 denotes Mcm4
T9770 669-677 GO:0097373 denotes Mcm4/6/7
T9771 688-700 GO:0006272 denotes 3′-extension
T9772 718-726 NCBITaxon:2157 denotes archaeal
T9773 727-730 GO:0042555 denotes Mcm
T9774 731-739 GO_EXT:0004386 denotes helicase
T9775 751-755 PR_EXT:000010246 denotes Mcm4
T9776 751-759 GO:0097373 denotes Mcm4/6/7
T9777 765-772 NCBITaxon:4896 denotes S.pombe
T9778 777-789 NCBITaxon:4932 denotes S.cerevisiae
T9779 806-814 NCBITaxon:2157 denotes archaeal
T9780 815-818 GO:0042555 denotes Mcm
T9781 832-836 GO:0005657 denotes fork
T9782 845-855 NCBITaxon:2759 denotes eukaryotic
T9783 856-860 PR_EXT:000010246 denotes Mcm4
T9784 856-864 GO:0097373 denotes Mcm4/6/7
T9785 890-895 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T9786 899-918 CHEBI_SO_EXT:double_stranded_DNA denotes double-stranded DNA
T9787 957-962 NCBITaxon_EXT:yeast denotes yeast
T9788 963-966 GO:0042555 denotes Mcm
T9789 967-976 GO_EXT:0004386 denotes helicases
T9790 981-992 GO_EXT:biological_movement_or_translocation_process denotes translocate
T9791 996-1006 CHEBI_SO_EXT:double_stranded_DNA denotes duplex DNA
T9792 1044-1053 NCBITaxon:40674 denotes mammalian
T9793 1054-1058 PR_EXT:000010246 denotes Mcm4
T9794 1054-1062 GO:0097373 denotes Mcm4/6/7
T9795 1103-1112 SO_EXT:biological_sequence denotes sequences
T9796 1146-1153 CHEBI_EXT:adenine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes adenine
T9797 1158-1165 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T9798 1176-1187 GO:0006260 denotes replication
T9799 1176-1195 SO_EXT:0000296 denotes replication origins
T9800 1221-1224 GO:0042555 denotes Mcm
T9801 1277-1286 NCBITaxon:40674 denotes mammalian
T9802 1287-1290 CHEBI_SO_EXT:DNA denotes DNA
T9803 1287-1302 GO:0006260 denotes DNA replication
T9804 1346-1355 SO_EXT:biological_sequence denotes sequences
T9805 1361-1366 NCBITaxon:9606 denotes human
T9806 1367-1378 GO:0006260 denotes replication
T9807 1367-1386 SO_EXT:0000296 denotes replication origins
T9808 1399-1403 PR_EXT:000010246 denotes Mcm4
T9809 1399-1416 GO:0097373 denotes Mcm4/6/7 helicase
T9810 1408-1416 GO_EXT:0004386 denotes helicase
T9811 1423-1431 PR_EXT:000009861 denotes lamin-B2
T9812 1436-1441 PR_EXT:000000084 denotes c-myc
T9813 1442-1449 SO_EXT:0000296 denotes origins
T9814 1484-1487 GO:0042555 denotes Mcm
T9815 1488-1496 GO_EXT:0004386 denotes helicase
T9816 1552-1555 GO:0042555 denotes Mcm
T9817 1563-1566 CHEBI_SO_EXT:DNA denotes DNA
T9818 1563-1589 GO:0006270 denotes DNA replication initiation
T9819 1602-1607 PR_EXT:000000084 denotes c-myc
T9820 1677-1685 SO_EXT:biological_sequence denotes sequence
T9821 1701-1720 CHEBI_SO_EXT:single_stranded_DNA denotes single-stranded DNA
T9822 1728-1736 GO_EXT:0004386 denotes helicase
T9823 1749-1752 GO:0042555 denotes Mcm
T9824 1780-1787 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T9825 1833-1841 GO_EXT:0004386 denotes helicase
T9826 1900-1907 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T9827 1975-1982 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T9828 1983-1991 CHEBI_EXT:residue denotes residues
T9829 2031-2038 SO_EXT:sequence_repeat_unit_or_region denotes repeats
T9830 2045-2058 CHEBI_SO_EXT:dinucleotide denotes dinucleotides
T9831 2092-2096 PR_EXT:000010246 denotes Mcm4
T9832 2092-2100 GO:0097373 denotes Mcm4/6/7
T9833 2172-2191 CHEBI_SO_EXT:single_stranded_DNA denotes single-stranded DNA
T9834 2210-2218 GO_EXT:0004386 denotes helicase
T9835 2227-2235 GO_EXT:0004518 denotes Nuclease
T9836 2271-2278 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T9837 2368-2372 PR_EXT:000010246 denotes Mcm4
T9838 2368-2376 GO:0097373 denotes Mcm4/6/7
T9839 2377-2385 GO_EXT:0004386 denotes helicase
T9840 2434-2453 CHEBI_SO_EXT:single_stranded_DNA denotes single-stranded DNA
T9841 2459-2466 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T9842 2544-2547 CHEBI_SO_EXT:DNA denotes DNA
T9843 2558-2565 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T9844 2606-2614 SO_EXT:biological_sequence denotes sequence
T9845 2631-2634 GO:0042555 denotes Mcm
T9846 2635-2643 GO_EXT:0004386 denotes helicase
T9847 2729-2737 SO_EXT:biological_sequence denotes sequence
T9848 2811-2821 GO:0065007 denotes regulation
T9849 2844-2873 GO:0006270 denotes initiation of DNA replication
T9850 2858-2861 CHEBI_SO_EXT:DNA denotes DNA
T9851 2907-2911 CL_GO_EXT:cell denotes cell
T9852 2978-2989 GO:0006260 denotes replication
T9853 2978-2996 SO_EXT:0000296 denotes replication origin
T9854 3004-3010 SO_EXT:0001026 denotes genome
T9855 3034-3038 CL_GO_EXT:cell denotes cell
R6454 T9751 T9750 _lexicallyChainedTo duplex DNA,Unwinding of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T9665 39-43 PR:000010246 denotes Mcm4
T9666 39-47 GO:0097373 denotes Mcm4/6/7
T9667 101-105 PR:000010246 denotes Mcm4
T9668 101-109 GO:0097373 denotes Mcm4/6/7
T9669 147-162 SO:0000984 denotes single-stranded
T9670 216-231 SO:0000984 denotes single-stranded
T9671 246-258 _FRAGMENT denotes Unwinding of
T9672 263-273 GO:0032508 denotes duplex DNA
T9673 263-269 SO:0000985 denotes duplex
T9674 302-317 SO:0000984 denotes single-stranded
T9675 402-406 GO:0005657 denotes fork
T9676 415-427 GO:0006272 denotes 3′-extension
T9677 441-445 GO:0005657 denotes fork
T9678 453-457 GO:0005657 denotes fork
T9679 469-481 GO:0006273 denotes 5′-extension
T9680 534-549 SO:0000984 denotes single-stranded
T9681 561-565 PR:000010246 denotes Mcm4
T9682 561-569 GO:0097373 denotes Mcm4/6/7
T9683 583-592 GO:0097617 denotes annealing
T9684 614-622 SO:0000988 denotes circular
T9685 623-638 SO:0000984 denotes single-stranded
T9686 663-668 NCBITaxon:10088 denotes mouse
T9687 669-673 PR:000010246 denotes Mcm4
T9688 669-677 GO:0097373 denotes Mcm4/6/7
T9689 688-700 GO:0006272 denotes 3′-extension
T9690 718-726 NCBITaxon:2157 denotes archaeal
T9691 727-730 GO:0042555 denotes Mcm
T9692 751-755 PR:000010246 denotes Mcm4
T9693 751-759 GO:0097373 denotes Mcm4/6/7
T9694 765-772 NCBITaxon:4896 denotes S.pombe
T9695 777-789 NCBITaxon:4932 denotes S.cerevisiae
T9696 806-814 NCBITaxon:2157 denotes archaeal
T9697 815-818 GO:0042555 denotes Mcm
T9698 832-836 GO:0005657 denotes fork
T9699 845-855 NCBITaxon:2759 denotes eukaryotic
T9700 856-860 PR:000010246 denotes Mcm4
T9701 856-864 GO:0097373 denotes Mcm4/6/7
T9702 899-914 SO:0000985 denotes double-stranded
T9703 963-966 GO:0042555 denotes Mcm
T9704 996-1002 SO:0000985 denotes duplex
T9705 1044-1053 NCBITaxon:40674 denotes mammalian
T9706 1054-1058 PR:000010246 denotes Mcm4
T9707 1054-1062 GO:0097373 denotes Mcm4/6/7
T9708 1176-1187 GO:0006260 denotes replication
T9709 1176-1195 SO:0000296 denotes replication origins
T9710 1221-1224 GO:0042555 denotes Mcm
T9711 1277-1286 NCBITaxon:40674 denotes mammalian
T9712 1287-1302 GO:0006260 denotes DNA replication
T9713 1361-1366 NCBITaxon:9606 denotes human
T9714 1367-1378 GO:0006260 denotes replication
T9715 1367-1386 SO:0000296 denotes replication origins
T9716 1399-1403 PR:000010246 denotes Mcm4
T9717 1399-1416 GO:0097373 denotes Mcm4/6/7 helicase
T9718 1423-1431 PR:000009861 denotes lamin-B2
T9719 1436-1441 PR:000000084 denotes c-myc
T9720 1442-1449 SO:0000296 denotes origins
T9721 1484-1487 GO:0042555 denotes Mcm
T9722 1552-1555 GO:0042555 denotes Mcm
T9723 1563-1589 GO:0006270 denotes DNA replication initiation
T9724 1602-1607 PR:000000084 denotes c-myc
T9725 1701-1716 SO:0000984 denotes single-stranded
T9726 1749-1752 GO:0042555 denotes Mcm
T9727 2092-2096 PR:000010246 denotes Mcm4
T9728 2092-2100 GO:0097373 denotes Mcm4/6/7
T9729 2172-2187 SO:0000984 denotes single-stranded
T9730 2368-2372 PR:000010246 denotes Mcm4
T9731 2368-2376 GO:0097373 denotes Mcm4/6/7
T9732 2434-2449 SO:0000984 denotes single-stranded
T9733 2631-2634 GO:0042555 denotes Mcm
T9734 2811-2821 GO:0065007 denotes regulation
T9735 2844-2873 GO:0006270 denotes initiation of DNA replication
T9736 2978-2989 GO:0006260 denotes replication
T9737 2978-2996 SO:0000296 denotes replication origin
T9738 3004-3010 SO:0001026 denotes genome
R6453 T9672 T9671 _lexicallyChainedTo duplex DNA,Unwinding of

2_test

Id Subject Object Predicate Lexical cue
15917436-11136247-76775539 791-793 11136247 denotes 14
15917436-13679365-76775540 794-796 13679365 denotes 26
15917436-12975364-76775541 797-799 12975364 denotes 27
15917436-12548282-76775542 944-945 12548282 denotes 5
15917436-12975364-76775543 946-948 12975364 denotes 27
15917436-15190069-76775544 1631-1633 15190069 denotes 33