PMC:1140370 / 30629-31007
Annnotations
craft-sa-dev
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Although we cannot totally exclude the possibility that one Mcm4/6/7 hexamer at each fork unwinds the duplex independently, ring-shaped structures of mouse and archea MCM, as revealed by electron microscopy, bear much similarity to the recently solved structure of the SV40 large T-antigen (4,6), and are in favor of the double-hexameric structure of mouse Mcm on a bubble DNA."}
craft-ca-core-ex-dev
{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T9074","span":{"begin":61,"end":65},"obj":"PR_EXT:000010246"},{"id":"T9075","span":{"begin":61,"end":69},"obj":"GO:0097373"},{"id":"T9076","span":{"begin":70,"end":77},"obj":"GO_EXT:hexameric_macromolecular_complex"},{"id":"T9077","span":{"begin":86,"end":90},"obj":"GO:0005657"},{"id":"T9078","span":{"begin":151,"end":156},"obj":"NCBITaxon:10088"},{"id":"T9079","span":{"begin":161,"end":167},"obj":"NCBITaxon:2157"},{"id":"T9080","span":{"begin":168,"end":171},"obj":"GO:0042555"},{"id":"T9081","span":{"begin":188,"end":196},"obj":"CHEBI:10545"},{"id":"T9082","span":{"begin":270,"end":274},"obj":"NCBITaxon:10633"},{"id":"T9083","span":{"begin":283,"end":290},"obj":"CHEBI_EXT:59132"},{"id":"T9084","span":{"begin":322,"end":338},"obj":"GO_EXT:double_hexameric_macromolecular_complex"},{"id":"T9085","span":{"begin":352,"end":357},"obj":"NCBITaxon:10088"},{"id":"T9086","span":{"begin":358,"end":361},"obj":"GO:0042555"},{"id":"T9087","span":{"begin":374,"end":377},"obj":"CHEBI_SO_EXT:DNA"}],"text":" Although we cannot totally exclude the possibility that one Mcm4/6/7 hexamer at each fork unwinds the duplex independently, ring-shaped structures of mouse and archea MCM, as revealed by electron microscopy, bear much similarity to the recently solved structure of the SV40 large T-antigen (4,6), and are in favor of the double-hexameric structure of mouse Mcm on a bubble DNA."}
craft-ca-core-dev
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2_test
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