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The thermal stability of the I:C base pair is lower than that of the G:C base pair in duplex DNA due to loss of one hydrogen bond and is even lower than A:T base pair (31). We constructed the T-tailed fork substrates containing the (GCC:CGG)10, (GCC:CIG)10 or (GAA:CTT)10 duplex DNA segment (Figure 8E). Mcm4/6/7 hardly displaced the 31 nt long duplex of GCC:CGG repeats, whereas the T-fork/(GAA:CTT)10 was displaced efficiently, as described above. T-fork/(GCC:CIG)10 was displaced with efficiency much greater than that of T-fork/(GCC:CGG)10, indicating that the thermostability of the duplex segment, not the lack of AT base pair, is responsible for inability of Mcm4/6/7 to displace the duplex."}

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{"project":"craft-ca-core-dev","denotations":[{"id":"T7582","span":{"begin":69,"end":73},"obj":"GO:0005657"},{"id":"T7583","span":{"begin":178,"end":187},"obj":"SO:0000028"},{"id":"T7584","span":{"begin":218,"end":227},"obj":"SO:0000028"},{"id":"T7585","span":{"begin":231,"end":237},"obj":"SO:0000985"},{"id":"T7586","span":{"begin":302,"end":311},"obj":"SO:0000028"},{"id":"T7587","span":{"begin":346,"end":350},"obj":"GO:0005657"},{"id":"T7588","span":{"begin":417,"end":423},"obj":"SO:0000985"},{"id":"T7589","span":{"begin":449,"end":453},"obj":"PR:000010246"},{"id":"T7590","span":{"begin":449,"end":457},"obj":"GO:0097373"},{"id":"T7591","span":{"begin":531,"end":535},"obj":"GO:0005657"},{"id":"T7592","span":{"begin":597,"end":601},"obj":"GO:0005657"},{"id":"T7593","span":{"begin":672,"end":676},"obj":"GO:0005657"},{"id":"T7594","span":{"begin":733,"end":739},"obj":"SO:0000985"},{"id":"T7595","span":{"begin":768,"end":777},"obj":"SO:0000028"},{"id":"T7596","span":{"begin":811,"end":815},"obj":"PR:000010246"},{"id":"T7597","span":{"begin":811,"end":819},"obj":"GO:0097373"}],"text":"In order to distinguish these two possibilities, we designed a new T-fork substrate containing inosine (I) residue instead of guanosine residue. The thermal stability of the I:C base pair is lower than that of the G:C base pair in duplex DNA due to loss of one hydrogen bond and is even lower than A:T base pair (31). We constructed the T-tailed fork substrates containing the (GCC:CGG)10, (GCC:CIG)10 or (GAA:CTT)10 duplex DNA segment (Figure 8E). Mcm4/6/7 hardly displaced the 31 nt long duplex of GCC:CGG repeats, whereas the T-fork/(GAA:CTT)10 was displaced efficiently, as described above. T-fork/(GCC:CIG)10 was displaced with efficiency much greater than that of T-fork/(GCC:CGG)10, indicating that the thermostability of the duplex segment, not the lack of AT base pair, is responsible for inability of Mcm4/6/7 to displace the duplex."}

{"project":"2_test","denotations":[{"id":"15917436-4080553-76775531","span":{"begin":313,"end":315},"obj":"4080553"}],"text":"In order to distinguish these two possibilities, we designed a new T-fork substrate containing inosine (I) residue instead of guanosine residue. The thermal stability of the I:C base pair is lower than that of the G:C base pair in duplex DNA due to loss of one hydrogen bond and is even lower than A:T base pair (31). We constructed the T-tailed fork substrates containing the (GCC:CGG)10, (GCC:CIG)10 or (GAA:CTT)10 duplex DNA segment (Figure 8E). Mcm4/6/7 hardly displaced the 31 nt long duplex of GCC:CGG repeats, whereas the T-fork/(GAA:CTT)10 was displaced efficiently, as described above. T-fork/(GCC:CIG)10 was displaced with efficiency much greater than that of T-fork/(GCC:CGG)10, indicating that the thermostability of the duplex segment, not the lack of AT base pair, is responsible for inability of Mcm4/6/7 to displace the duplex."}