PMC:1140370 / 24154-24573
Annnotations
craft-sa-dev
{"project":"craft-sa-dev","denotations":[{"id":"T7339","span":{"begin":0,"end":2},"obj":"IN"},{"id":"T7340","span":{"begin":30,"end":35},"obj":"VBD"},{"id":"T7341","span":{"begin":3,"end":6},"obj":"NN"},{"id":"T7342","span":{"begin":7,"end":12},"obj":"NN"},{"id":"T7343","span":{"begin":13,"end":19},"obj":"NNS"},{"id":"T7344","span":{"begin":19,"end":21},"obj":","},{"id":"T7345","span":{"begin":21,"end":25},"obj":"NN"},{"id":"T7346","span":{"begin":25,"end":26},"obj":"HYPH"},{"id":"T7347","span":{"begin":26,"end":27},"obj":"CD"},{"id":"T7348","span":{"begin":27,"end":28},"obj":"HYPH"},{"id":"T7349","span":{"begin":28,"end":29},"obj":"CD"},{"id":"T7350","span":{"begin":36,"end":38},"obj":"IN"},{"id":"T7351","span":{"begin":39,"end":42},"obj":"PDT"},{"id":"T7352","span":{"begin":53,"end":60},"obj":"NNS"},{"id":"T7353","span":{"begin":43,"end":46},"obj":"DT"},{"id":"T7354","span":{"begin":47,"end":52},"obj":"CD"},{"id":"T7355","span":{"begin":60,"end":62},"obj":","},{"id":"T7356","span":{"begin":62,"end":70},"obj":"IN"},{"id":"T7357","span":{"begin":128,"end":130},"obj":"VBZ"},{"id":"T7358","span":{"begin":71,"end":74},"obj":"DT"},{"id":"T7359","span":{"begin":75,"end":83},"obj":"NN"},{"id":"T7360","span":{"begin":84,"end":86},"obj":"IN"},{"id":"T7361","span":{"begin":87,"end":92},"obj":"NN"},{"id":"T7362","span":{"begin":99,"end":102},"obj":"NN"},{"id":"T7363","span":{"begin":92,"end":93},"obj":"HYPH"},{"id":"T7364","span":{"begin":93,"end":94},"obj":"NN"},{"id":"T7365","span":{"begin":95,"end":98},"obj":"NN"},{"id":"T7366","span":{"begin":94,"end":95},"obj":"HYPH"},{"id":"T7367","span":{"begin":98,"end":99},"obj":"HYPH"},{"id":"T7368","span":{"begin":103,"end":106},"obj":"CC"},{"id":"T7369","span":{"begin":107,"end":109},"obj":"IN"},{"id":"T7370","span":{"begin":110,"end":115},"obj":"NN"},{"id":"T7371","span":{"begin":126,"end":127},"obj":"NN"},{"id":"T7372","span":{"begin":115,"end":116},"obj":"HYPH"},{"id":"T7373","span":{"begin":116,"end":117},"obj":"NN"},{"id":"T7374","span":{"begin":118,"end":121},"obj":"NN"},{"id":"T7375","span":{"begin":117,"end":118},"obj":"HYPH"},{"id":"T7376","span":{"begin":121,"end":122},"obj":"HYPH"},{"id":"T7377","span":{"begin":122,"end":125},"obj":"NN"},{"id":"T7378","span":{"begin":125,"end":126},"obj":"HYPH"},{"id":"T7379","span":{"begin":131,"end":139},"obj":"RB"},{"id":"T7380","span":{"begin":140,"end":145},"obj":"JJR"},{"id":"T7381","span":{"begin":146,"end":150},"obj":"IN"},{"id":"T7382","span":{"begin":151,"end":155},"obj":"DT"},{"id":"T7383","span":{"begin":156,"end":158},"obj":"IN"},{"id":"T7384","span":{"begin":159,"end":162},"obj":"NN"},{"id":"T7385","span":{"begin":172,"end":174},"obj":"NN"},{"id":"T7386","span":{"begin":162,"end":163},"obj":"HYPH"},{"id":"T7387","span":{"begin":163,"end":165},"obj":"CD"},{"id":"T7388","span":{"begin":165,"end":166},"obj":"HYPH"},{"id":"T7389","span":{"begin":166,"end":171},"obj":"NN"},{"id":"T7390","span":{"begin":175,"end":176},"obj":"-LRB-"},{"id":"T7391","span":{"begin":183,"end":185},"obj":"NN"},{"id":"T7392","span":{"begin":176,"end":182},"obj":"NN"},{"id":"T7393","span":{"begin":185,"end":186},"obj":"-RRB-"},{"id":"T7394","span":{"begin":186,"end":187},"obj":"."},{"id":"T7395","span":{"begin":187,"end":280},"obj":"sentence"},{"id":"T7396","span":{"begin":188,"end":197},"obj":"RB"},{"id":"T7397","span":{"begin":254,"end":263},"obj":"VB"},{"id":"T7398","span":{"begin":197,"end":199},"obj":","},{"id":"T7399","span":{"begin":199,"end":207},"obj":"NN"},{"id":"T7400","span":{"begin":224,"end":234},"obj":"NNS"},{"id":"T7401","span":{"begin":208,"end":211},"obj":"CC"},{"id":"T7402","span":{"begin":212,"end":215},"obj":"NN"},{"id":"T7403","span":{"begin":216,"end":223},"obj":"NN"},{"id":"T7404","span":{"begin":235,"end":237},"obj":"VBP"},{"id":"T7405","span":{"begin":238,"end":241},"obj":"RB"},{"id":"T7406","span":{"begin":242,"end":253},"obj":"RB"},{"id":"T7407","span":{"begin":264,"end":268},"obj":"IN"},{"id":"T7408","span":{"begin":269,"end":273},"obj":"DT"},{"id":"T7409","span":{"begin":274,"end":279},"obj":"JJ"},{"id":"T7410","span":{"begin":279,"end":280},"obj":"."},{"id":"T7411","span":{"begin":280,"end":419},"obj":"sentence"},{"id":"T7412","span":{"begin":281,"end":285},"obj":"DT"},{"id":"T7413","span":{"begin":295,"end":304},"obj":"VBN"},{"id":"T7414","span":{"begin":286,"end":289},"obj":"VBD"},{"id":"T7415","span":{"begin":290,"end":294},"obj":"RB"},{"id":"T7416","span":{"begin":305,"end":307},"obj":"IN"},{"id":"T7417","span":{"begin":308,"end":311},"obj":"PRP$"},{"id":"T7418","span":{"begin":321,"end":328},"obj":"NNS"},{"id":"T7419","span":{"begin":312,"end":320},"obj":"JJ"},{"id":"T7420","span":{"begin":329,"end":333},"obj":"IN"},{"id":"T7421","span":{"begin":369,"end":373},"obj":"VB"},{"id":"T7422","span":{"begin":334,"end":341},"obj":"NN"},{"id":"T7423","span":{"begin":355,"end":364},"obj":"NNS"},{"id":"T7424","span":{"begin":342,"end":345},"obj":"CC"},{"id":"T7425","span":{"begin":346,"end":354},"obj":"NN"},{"id":"T7426","span":{"begin":365,"end":368},"obj":"MD"},{"id":"T7427","span":{"begin":374,"end":376},"obj":"IN"},{"id":"T7428","span":{"begin":377,"end":380},"obj":"NN"},{"id":"T7429","span":{"begin":381,"end":384},"obj":"CC"},{"id":"T7430","span":{"begin":385,"end":388},"obj":"MD"},{"id":"T7431","span":{"begin":392,"end":400},"obj":"VB"},{"id":"T7432","span":{"begin":388,"end":391},"obj":"RB"},{"id":"T7433","span":{"begin":401,"end":404},"obj":"DT"},{"id":"T7434","span":{"begin":405,"end":413},"obj":"NN"},{"id":"T7435","span":{"begin":414,"end":415},"obj":"-LRB-"},{"id":"T7436","span":{"begin":415,"end":417},"obj":"CD"},{"id":"T7437","span":{"begin":417,"end":418},"obj":"-RRB-"},{"id":"T7438","span":{"begin":418,"end":419},"obj":"."}],"relations":[{"id":"R5028","pred":"prep","subj":"T7339","obj":"T7340"},{"id":"R5029","pred":"compound","subj":"T7341","obj":"T7342"},{"id":"R5030","pred":"compound","subj":"T7342","obj":"T7343"},{"id":"R5031","pred":"pobj","subj":"T7343","obj":"T7339"},{"id":"R5032","pred":"punct","subj":"T7344","obj":"T7340"},{"id":"R5033","pred":"nsubj","subj":"T7345","obj":"T7340"},{"id":"R5034","pred":"punct","subj":"T7346","obj":"T7345"},{"id":"R5035","pred":"nummod","subj":"T7347","obj":"T7345"},{"id":"R5036","pred":"punct","subj":"T7348","obj":"T7345"},{"id":"R5037","pred":"nummod","subj":"T7349","obj":"T7345"},{"id":"R5038","pred":"prep","subj":"T7350","obj":"T7340"},{"id":"R5039","pred":"predet","subj":"T7351","obj":"T7352"},{"id":"R5040","pred":"pobj","subj":"T7352","obj":"T7350"},{"id":"R5041","pred":"det","subj":"T7353","obj":"T7352"},{"id":"R5042","pred":"nummod","subj":"T7354","obj":"T7352"},{"id":"R5043","pred":"punct","subj":"T7355","obj":"T7340"},{"id":"R5044","pred":"mark","subj":"T7356","obj":"T7357"},{"id":"R5045","pred":"advcl","subj":"T7357","obj":"T7340"},{"id":"R5046","pred":"det","subj":"T7358","obj":"T7359"},{"id":"R5047","pred":"nsubj","subj":"T7359","obj":"T7357"},{"id":"R5048","pred":"prep","subj":"T7360","obj":"T7359"},{"id":"R5049","pred":"compound","subj":"T7361","obj":"T7362"},{"id":"R5050","pred":"pobj","subj":"T7362","obj":"T7360"},{"id":"R5051","pred":"punct","subj":"T7363","obj":"T7362"},{"id":"R5052","pred":"compound","subj":"T7364","obj":"T7365"},{"id":"R5053","pred":"compound","subj":"T7365","obj":"T7362"},{"id":"R5054","pred":"punct","subj":"T7366","obj":"T7365"},{"id":"R5055","pred":"punct","subj":"T7367","obj":"T7362"},{"id":"R5056","pred":"cc","subj":"T7368","obj":"T7360"},{"id":"R5057","pred":"conj","subj":"T7369","obj":"T7360"},{"id":"R5058","pred":"compound","subj":"T7370","obj":"T7371"},{"id":"R5059","pred":"pobj","subj":"T7371","obj":"T7369"},{"id":"R5060","pred":"punct","subj":"T7372","obj":"T7371"},{"id":"R5061","pred":"compound","subj":"T7373","obj":"T7374"},{"id":"R5062","pred":"compound","subj":"T7374","obj":"T7371"},{"id":"R5063","pred":"punct","subj":"T7375","obj":"T7374"},{"id":"R5064","pred":"punct","subj":"T7376","obj":"T7371"},{"id":"R5065","pred":"compound","subj":"T7377","obj":"T7371"},{"id":"R5066","pred":"punct","subj":"T7378","obj":"T7371"},{"id":"R5067","pred":"advmod","subj":"T7379","obj":"T7380"},{"id":"R5068","pred":"acomp","subj":"T7380","obj":"T7357"},{"id":"R5069","pred":"prep","subj":"T7381","obj":"T7380"},{"id":"R5070","pred":"pobj","subj":"T7382","obj":"T7381"},{"id":"R5071","pred":"prep","subj":"T7383","obj":"T7382"},{"id":"R5072","pred":"nmod","subj":"T7384","obj":"T7385"},{"id":"R5073","pred":"pobj","subj":"T7385","obj":"T7383"},{"id":"R5074","pred":"punct","subj":"T7386","obj":"T7385"},{"id":"R5075","pred":"nummod","subj":"T7387","obj":"T7385"},{"id":"R5076","pred":"punct","subj":"T7388","obj":"T7385"},{"id":"R5077","pred":"compound","subj":"T7389","obj":"T7385"},{"id":"R5078","pred":"punct","subj":"T7390","obj":"T7391"},{"id":"R5079","pred":"parataxis","subj":"T7391","obj":"T7357"},{"id":"R5080","pred":"compound","subj":"T7392","obj":"T7391"},{"id":"R5081","pred":"punct","subj":"T7393","obj":"T7391"},{"id":"R5082","pred":"punct","subj":"T7394","obj":"T7340"},{"id":"R5083","pred":"advmod","subj":"T7396","obj":"T7397"},{"id":"R5084","pred":"punct","subj":"T7398","obj":"T7397"},{"id":"R5085","pred":"nmod","subj":"T7399","obj":"T7400"},{"id":"R5086","pred":"nsubj","subj":"T7400","obj":"T7397"},{"id":"R5087","pred":"cc","subj":"T7401","obj":"T7399"},{"id":"R5088","pred":"compound","subj":"T7402","obj":"T7403"},{"id":"R5089","pred":"conj","subj":"T7403","obj":"T7399"},{"id":"R5090","pred":"aux","subj":"T7404","obj":"T7397"},{"id":"R5091","pred":"neg","subj":"T7405","obj":"T7397"},{"id":"R5092","pred":"advmod","subj":"T7406","obj":"T7397"},{"id":"R5093","pred":"prep","subj":"T7407","obj":"T7397"},{"id":"R5094","pred":"det","subj":"T7408","obj":"T7409"},{"id":"R5095","pred":"pobj","subj":"T7409","obj":"T7407"},{"id":"R5096","pred":"punct","subj":"T7410","obj":"T7397"},{"id":"R5097","pred":"nsubjpass","subj":"T7412","obj":"T7413"},{"id":"R5098","pred":"auxpass","subj":"T7414","obj":"T7413"},{"id":"R5099","pred":"advmod","subj":"T7415","obj":"T7413"},{"id":"R5100","pred":"agent","subj":"T7416","obj":"T7413"},{"id":"R5101","pred":"poss","subj":"T7417","obj":"T7418"},{"id":"R5102","pred":"pobj","subj":"T7418","obj":"T7416"},{"id":"R5103","pred":"amod","subj":"T7419","obj":"T7418"},{"id":"R5104","pred":"mark","subj":"T7420","obj":"T7421"},{"id":"R5105","pred":"acl","subj":"T7421","obj":"T7418"},{"id":"R5106","pred":"nmod","subj":"T7422","obj":"T7423"},{"id":"R5107","pred":"nsubj","subj":"T7423","obj":"T7421"},{"id":"R5108","pred":"cc","subj":"T7424","obj":"T7422"},{"id":"R5109","pred":"conj","subj":"T7425","obj":"T7422"},{"id":"R5110","pred":"aux","subj":"T7426","obj":"T7421"},{"id":"R5111","pred":"prep","subj":"T7427","obj":"T7421"},{"id":"R5112","pred":"pobj","subj":"T7428","obj":"T7427"},{"id":"R5113","pred":"cc","subj":"T7429","obj":"T7421"},{"id":"R5114","pred":"aux","subj":"T7430","obj":"T7431"},{"id":"R5115","pred":"conj","subj":"T7431","obj":"T7421"},{"id":"R5116","pred":"neg","subj":"T7432","obj":"T7431"},{"id":"R5117","pred":"det","subj":"T7433","obj":"T7434"},{"id":"R5118","pred":"dobj","subj":"T7434","obj":"T7431"},{"id":"R5119","pred":"punct","subj":"T7435","obj":"T7436"},{"id":"R5120","pred":"parataxis","subj":"T7436","obj":"T7431"},{"id":"R5121","pred":"punct","subj":"T7437","obj":"T7436"},{"id":"R5122","pred":"punct","subj":"T7438","obj":"T7413"}],"text":"In gel shift assays, MCM4/6/7 bound to all the three bubbles, although the affinity to Bub82/c-myc/DUE and to Bub82/c-myc/DUE-C is slightly lower than that to Bub-82/lamin B2 (Figure 7B). Therefore, helicase and DNA binding activities do not necessarily correlate with each other. This was also indicated by our previous results that guanine and cytosine stretches can bind to Mcm but cannot activate the helicase (13)."}
craft-ca-core-ex-dev
{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T6994","span":{"begin":21,"end":25},"obj":"PR_EXT:000010246"},{"id":"T6995","span":{"begin":21,"end":29},"obj":"GO:0097373"},{"id":"T6996","span":{"begin":30,"end":35},"obj":"CHEMINF_GO_EXT:chemical_binding_or_bond_formation"},{"id":"T6997","span":{"begin":93,"end":98},"obj":"PR_EXT:000000084"},{"id":"T6998","span":{"begin":116,"end":121},"obj":"PR_EXT:000000084"},{"id":"T6999","span":{"begin":166,"end":174},"obj":"PR_EXT:000009861"},{"id":"T7000","span":{"begin":199,"end":207},"obj":"GO_EXT:0004386"},{"id":"T7001","span":{"begin":212,"end":215},"obj":"CHEBI_SO_EXT:DNA"},{"id":"T7002","span":{"begin":216,"end":223},"obj":"CHEMINF_GO_EXT:chemical_binding_or_bond_formation"},{"id":"T7003","span":{"begin":334,"end":341},"obj":"CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group"},{"id":"T7004","span":{"begin":346,"end":354},"obj":"CHEBI_EXT:cytosine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group"},{"id":"T7005","span":{"begin":369,"end":373},"obj":"CHEMINF_GO_EXT:chemical_binding_or_bond_formation"},{"id":"T7006","span":{"begin":377,"end":380},"obj":"GO:0042555"},{"id":"T7007","span":{"begin":405,"end":413},"obj":"GO_EXT:0004386"}],"text":"In gel shift assays, MCM4/6/7 bound to all the three bubbles, although the affinity to Bub82/c-myc/DUE and to Bub82/c-myc/DUE-C is slightly lower than that to Bub-82/lamin B2 (Figure 7B). Therefore, helicase and DNA binding activities do not necessarily correlate with each other. This was also indicated by our previous results that guanine and cytosine stretches can bind to Mcm but cannot activate the helicase (13)."}
craft-ca-core-dev
{"project":"craft-ca-core-dev","denotations":[{"id":"T6930","span":{"begin":21,"end":25},"obj":"PR:000010246"},{"id":"T6931","span":{"begin":21,"end":29},"obj":"GO:0097373"},{"id":"T6932","span":{"begin":93,"end":98},"obj":"PR:000000084"},{"id":"T6933","span":{"begin":116,"end":121},"obj":"PR:000000084"},{"id":"T6934","span":{"begin":166,"end":174},"obj":"PR:000009861"},{"id":"T6935","span":{"begin":377,"end":380},"obj":"GO:0042555"}],"text":"In gel shift assays, MCM4/6/7 bound to all the three bubbles, although the affinity to Bub82/c-myc/DUE and to Bub82/c-myc/DUE-C is slightly lower than that to Bub-82/lamin B2 (Figure 7B). Therefore, helicase and DNA binding activities do not necessarily correlate with each other. This was also indicated by our previous results that guanine and cytosine stretches can bind to Mcm but cannot activate the helicase (13)."}
2_test
{"project":"2_test","denotations":[{"id":"15917436-14609960-76775529","span":{"begin":415,"end":417},"obj":"14609960"}],"text":"In gel shift assays, MCM4/6/7 bound to all the three bubbles, although the affinity to Bub82/c-myc/DUE and to Bub82/c-myc/DUE-C is slightly lower than that to Bub-82/lamin B2 (Figure 7B). Therefore, helicase and DNA binding activities do not necessarily correlate with each other. This was also indicated by our previous results that guanine and cytosine stretches can bind to Mcm but cannot activate the helicase (13)."}