> top > docs > PMC:1140370 > spans > 22642-24573 > annotations

PMC:1140370 / 22642-24573 JSONTXT

Annnotations TAB JSON ListView MergeView

craft-sa-dev

Id Subject Object Predicate Lexical cue
T7008 0-3 NN denotes DUE
T7009 4-13 NNS denotes sequences
T7010 36-44 VBP denotes activate
T7011 14-18 IN denotes from
T7012 19-22 DT denotes the
T7013 29-35 NN denotes origin
T7014 23-24 NN denotes c
T7015 25-28 NN denotes myc
T7016 24-25 HYPH denotes -
T7017 45-48 NN denotes Mcm
T7018 49-57 NN denotes helicase
T7019 57-357 sentence denotes Our previous studies have shown that the sequences containing periodic (dT)n tracts derived from the human lamin B2 origin (48% thymine content) can serve as an efficient activator for the Mcm helicase on a bubble, and replacement of thymines with guanines abolished the helicase activation (13,28).
T7020 58-61 PRP$ denotes Our
T7021 71-78 NNS denotes studies
T7022 62-70 JJ denotes previous
T7023 84-89 VBN denotes shown
T7024 79-83 VBP denotes have
T7025 90-94 IN denotes that
T7026 207-212 VB denotes serve
T7027 95-98 DT denotes the
T7028 99-108 NNS denotes sequences
T7029 109-119 VBG denotes containing
T7030 120-128 JJ denotes periodic
T7031 135-141 NNS denotes tracts
T7032 129-130 -LRB- denotes (
T7033 133-134 NN denotes n
T7034 130-132 NN denotes dT
T7035 132-133 -RRB- denotes )
T7036 142-149 VBN denotes derived
T7037 150-154 IN denotes from
T7038 155-158 DT denotes the
T7039 174-180 NN denotes origin
T7040 159-164 JJ denotes human
T7041 165-170 NN denotes lamin
T7042 171-173 NN denotes B2
T7043 181-182 -LRB- denotes (
T7044 194-201 NN denotes content
T7045 182-184 CD denotes 48
T7046 184-185 NN denotes %
T7047 186-193 NN denotes thymine
T7048 201-202 -RRB- denotes )
T7049 203-206 MD denotes can
T7050 213-215 IN denotes as
T7051 216-218 DT denotes an
T7052 229-238 NN denotes activator
T7053 219-228 JJ denotes efficient
T7054 239-242 IN denotes for
T7055 243-246 DT denotes the
T7056 251-259 NN denotes helicase
T7057 247-250 NN denotes Mcm
T7058 260-262 IN denotes on
T7059 263-264 DT denotes a
T7060 265-271 NN denotes bubble
T7061 271-273 , denotes ,
T7062 273-276 CC denotes and
T7063 277-288 NN denotes replacement
T7064 315-324 VBD denotes abolished
T7065 289-291 IN denotes of
T7066 292-300 NNS denotes thymines
T7067 301-305 IN denotes with
T7068 306-314 NNS denotes guanines
T7069 325-328 DT denotes the
T7070 338-348 NN denotes activation
T7071 329-337 NN denotes helicase
T7072 349-350 -LRB- denotes (
T7073 353-355 CD denotes 28
T7074 350-352 CD denotes 13
T7075 352-353 , denotes ,
T7076 355-356 -RRB- denotes )
T7077 356-357 . denotes .
T7078 357-715 sentence denotes In order to examine other natural replication origins with different thymine contents for the ability to activate Mcm helicase on a bubble substrate, we constructed new bubble substrates, Bub82/c-myc, containing sequences derived from the DUE (DNA unwinding element) region of the human c-myc origin which is essential for c-myc replicator activity (29,30).
T7079 358-360 IN denotes In
T7080 511-522 VBD denotes constructed
T7081 361-366 NN denotes order
T7082 367-369 TO denotes to
T7083 370-377 VB denotes examine
T7084 378-383 JJ denotes other
T7085 404-411 NNS denotes origins
T7086 384-391 JJ denotes natural
T7087 392-403 NN denotes replication
T7088 412-416 IN denotes with
T7089 417-426 JJ denotes different
T7090 435-443 NNS denotes contents
T7091 427-434 NN denotes thymine
T7092 444-447 IN denotes for
T7093 448-451 DT denotes the
T7094 452-459 NN denotes ability
T7095 460-462 TO denotes to
T7096 463-471 VB denotes activate
T7097 472-475 NN denotes Mcm
T7098 476-484 NN denotes helicase
T7099 485-487 IN denotes on
T7100 488-489 DT denotes a
T7101 497-506 NN denotes substrate
T7102 490-496 NN denotes bubble
T7103 506-508 , denotes ,
T7104 508-510 PRP denotes we
T7105 523-526 JJ denotes new
T7106 534-544 NNS denotes substrates
T7107 527-533 NN denotes bubble
T7108 544-546 , denotes ,
T7109 546-551 NN denotes Bub82
T7110 554-557 NN denotes myc
T7111 551-552 HYPH denotes /
T7112 552-553 NN denotes c
T7113 553-554 HYPH denotes -
T7114 557-559 , denotes ,
T7115 559-569 VBG denotes containing
T7116 570-579 NNS denotes sequences
T7117 580-587 VBN denotes derived
T7118 588-592 IN denotes from
T7119 593-596 DT denotes the
T7120 625-631 NN denotes region
T7121 597-600 NN denotes DUE
T7122 601-602 -LRB- denotes (
T7123 602-605 NN denotes DNA
T7124 616-623 NN denotes element
T7125 606-615 NN denotes unwinding
T7126 623-624 -RRB- denotes )
T7127 632-634 IN denotes of
T7128 635-638 DT denotes the
T7129 651-657 NN denotes origin
T7130 639-644 JJ denotes human
T7131 645-646 NN denotes c
T7132 647-650 NN denotes myc
T7133 646-647 HYPH denotes -
T7134 658-663 WDT denotes which
T7135 664-666 VBZ denotes is
T7136 667-676 JJ denotes essential
T7137 677-680 IN denotes for
T7138 681-682 NN denotes c
T7139 683-686 NN denotes myc
T7140 682-683 HYPH denotes -
T7141 698-706 NN denotes activity
T7142 687-697 NN denotes replicator
T7143 707-708 -LRB- denotes (
T7144 711-713 CD denotes 30
T7145 708-710 CD denotes 29
T7146 710-711 , denotes ,
T7147 713-714 -RRB- denotes )
T7148 714-715 . denotes .
T7149 715-837 sentence denotes The unpaired segment in Bub82/c-myc/DUE contains one strand of DUE and that in Bub82/c-myc/DUE-C contains another strand.
T7150 716-719 DT denotes The
T7151 729-736 NN denotes segment
T7152 720-728 JJ denotes unpaired
T7153 756-764 VBZ denotes contains
T7154 737-739 IN denotes in
T7155 740-745 NN denotes Bub82
T7156 752-755 NN denotes DUE
T7157 745-746 HYPH denotes /
T7158 746-747 NN denotes c
T7159 748-751 NN denotes myc
T7160 747-748 HYPH denotes -
T7161 751-752 HYPH denotes /
T7162 765-768 CD denotes one
T7163 769-775 NN denotes strand
T7164 776-778 IN denotes of
T7165 779-782 NN denotes DUE
T7166 783-786 CC denotes and
T7167 787-791 DT denotes that
T7168 813-821 VBZ denotes contains
T7169 792-794 IN denotes in
T7170 795-800 NN denotes Bub82
T7171 811-812 NN denotes C
T7172 800-801 HYPH denotes /
T7173 801-802 NN denotes c
T7174 803-806 NN denotes myc
T7175 802-803 HYPH denotes -
T7176 806-807 HYPH denotes /
T7177 807-810 NN denotes DUE
T7178 810-811 HYPH denotes -
T7179 822-829 DT denotes another
T7180 830-836 NN denotes strand
T7181 836-837 . denotes .
T7182 837-999 sentence denotes This DUE is believed to coincide with the initially unwound region of the c-myc origin (29), and its deletion substantially reduced the replicator activity (30).
T7183 838-842 DT denotes This
T7184 843-846 NN denotes DUE
T7185 850-858 VBN denotes believed
T7186 847-849 VBZ denotes is
T7187 859-861 TO denotes to
T7188 862-870 VB denotes coincide
T7189 871-875 IN denotes with
T7190 876-879 DT denotes the
T7191 898-904 NN denotes region
T7192 880-889 RB denotes initially
T7193 890-897 JJ denotes unwound
T7194 905-907 IN denotes of
T7195 908-911 DT denotes the
T7196 918-924 NN denotes origin
T7197 912-913 NN denotes c
T7198 914-917 NN denotes myc
T7199 913-914 HYPH denotes -
T7200 925-926 -LRB- denotes (
T7201 926-928 CD denotes 29
T7202 928-929 -RRB- denotes )
T7203 929-931 , denotes ,
T7204 931-934 CC denotes and
T7205 935-938 PRP$ denotes its
T7206 939-947 NN denotes deletion
T7207 962-969 VBD denotes reduced
T7208 948-961 RB denotes substantially
T7209 970-973 DT denotes the
T7210 985-993 NN denotes activity
T7211 974-984 NN denotes replicator
T7212 994-995 -LRB- denotes (
T7213 995-997 CD denotes 30
T7214 997-998 -RRB- denotes )
T7215 998-999 . denotes .
T7216 999-1245 sentence denotes Mcm4/6/7 unwound Bub82/lamin B2 (thymine 48%), Bub82/c-myc/DUE (37%) and Bub82/c-myc/DUE-C (39%) with similar efficiency (Figure 7A), indicating that the sequences from the c-myc origin also can serve as efficient activators of the Mcm helicase.
T7217 1000-1004 NN denotes Mcm4
T7218 1009-1016 VBN denotes unwound
T7219 1004-1005 HYPH denotes /
T7220 1005-1006 CD denotes 6
T7221 1006-1007 HYPH denotes /
T7222 1007-1008 CD denotes 7
T7223 1017-1022 NN denotes Bub82
T7224 1029-1031 NN denotes B2
T7225 1022-1023 HYPH denotes /
T7226 1023-1028 NN denotes lamin
T7227 1032-1033 -LRB- denotes (
T7228 1043-1044 NN denotes %
T7229 1033-1040 NN denotes thymine
T7230 1041-1043 CD denotes 48
T7231 1044-1045 -RRB- denotes )
T7232 1045-1047 , denotes ,
T7233 1047-1052 NN denotes Bub82
T7234 1059-1062 NN denotes DUE
T7235 1052-1053 HYPH denotes /
T7236 1053-1054 NN denotes c
T7237 1055-1058 NN denotes myc
T7238 1054-1055 HYPH denotes -
T7239 1058-1059 HYPH denotes /
T7240 1063-1064 -LRB- denotes (
T7241 1066-1067 NN denotes %
T7242 1064-1066 CD denotes 37
T7243 1067-1068 -RRB- denotes )
T7244 1069-1072 CC denotes and
T7245 1073-1078 NN denotes Bub82
T7246 1089-1090 NN denotes C
T7247 1078-1079 HYPH denotes /
T7248 1079-1080 NN denotes c
T7249 1081-1084 NN denotes myc
T7250 1080-1081 HYPH denotes -
T7251 1084-1085 HYPH denotes /
T7252 1085-1088 NN denotes DUE
T7253 1088-1089 HYPH denotes -
T7254 1091-1092 -LRB- denotes (
T7255 1094-1095 NN denotes %
T7256 1092-1094 CD denotes 39
T7257 1095-1096 -RRB- denotes )
T7258 1097-1101 IN denotes with
T7259 1102-1109 JJ denotes similar
T7260 1110-1120 NN denotes efficiency
T7261 1121-1122 -LRB- denotes (
T7262 1129-1131 NN denotes 7A
T7263 1122-1128 NN denotes Figure
T7264 1131-1132 -RRB- denotes )
T7265 1132-1134 , denotes ,
T7266 1134-1144 VBG denotes indicating
T7267 1145-1149 IN denotes that
T7268 1195-1200 VB denotes serve
T7269 1150-1153 DT denotes the
T7270 1154-1163 NNS denotes sequences
T7271 1164-1168 IN denotes from
T7272 1169-1172 DT denotes the
T7273 1179-1185 NN denotes origin
T7274 1173-1174 NN denotes c
T7275 1175-1178 NN denotes myc
T7276 1174-1175 HYPH denotes -
T7277 1186-1190 RB denotes also
T7278 1191-1194 MD denotes can
T7279 1201-1203 IN denotes as
T7280 1204-1213 JJ denotes efficient
T7281 1214-1224 NNS denotes activators
T7282 1225-1227 IN denotes of
T7283 1228-1231 DT denotes the
T7284 1236-1244 NN denotes helicase
T7285 1232-1235 NN denotes Mcm
T7286 1244-1245 . denotes .
T7287 1245-1511 sentence denotes This result also indicates that sequences with 37% thymine content can activate Mcm4/6/7 to displace 24 nt duplex on both sides in a bubble substrate, suggesting that the not only thymine content but also the sequence context may affect the Mcm helicase activation.
T7288 1246-1250 DT denotes This
T7289 1251-1257 NN denotes result
T7290 1263-1272 VBZ denotes indicates
T7291 1258-1262 RB denotes also
T7292 1273-1277 IN denotes that
T7293 1317-1325 VB denotes activate
T7294 1278-1287 NNS denotes sequences
T7295 1288-1292 IN denotes with
T7296 1293-1295 CD denotes 37
T7297 1295-1296 NN denotes %
T7298 1305-1312 NN denotes content
T7299 1297-1304 NN denotes thymine
T7300 1313-1316 MD denotes can
T7301 1326-1330 NN denotes Mcm4
T7302 1330-1331 HYPH denotes /
T7303 1331-1332 CD denotes 6
T7304 1332-1333 HYPH denotes /
T7305 1333-1334 CD denotes 7
T7306 1335-1337 TO denotes to
T7307 1338-1346 VB denotes displace
T7308 1347-1349 CD denotes 24
T7309 1350-1352 NN denotes nt
T7310 1353-1359 NN denotes duplex
T7311 1360-1362 IN denotes on
T7312 1363-1367 DT denotes both
T7313 1368-1373 NNS denotes sides
T7314 1374-1376 IN denotes in
T7315 1377-1378 DT denotes a
T7316 1386-1395 NN denotes substrate
T7317 1379-1385 NN denotes bubble
T7318 1395-1397 , denotes ,
T7319 1397-1407 VBG denotes suggesting
T7320 1408-1412 IN denotes that
T7321 1476-1482 VB denotes affect
T7322 1413-1416 DT denotes the
T7323 1434-1441 NN denotes content
T7324 1417-1420 RB denotes not
T7325 1421-1425 RB denotes only
T7326 1426-1433 NN denotes thymine
T7327 1442-1445 CC denotes but
T7328 1446-1450 RB denotes also
T7329 1451-1454 DT denotes the
T7330 1464-1471 NN denotes context
T7331 1455-1463 NN denotes sequence
T7332 1472-1475 MD denotes may
T7333 1483-1486 DT denotes the
T7334 1500-1510 NN denotes activation
T7335 1487-1490 NN denotes Mcm
T7336 1491-1499 NN denotes helicase
T7337 1510-1511 . denotes .
T7338 1511-1699 sentence denotes In gel shift assays, MCM4/6/7 bound to all the three bubbles, although the affinity to Bub82/c-myc/DUE and to Bub82/c-myc/DUE-C is slightly lower than that to Bub-82/lamin B2 (Figure 7B).
T7339 1512-1514 IN denotes In
T7340 1542-1547 VBD denotes bound
T7341 1515-1518 NN denotes gel
T7342 1519-1524 NN denotes shift
T7343 1525-1531 NNS denotes assays
T7344 1531-1533 , denotes ,
T7345 1533-1537 NN denotes MCM4
T7346 1537-1538 HYPH denotes /
T7347 1538-1539 CD denotes 6
T7348 1539-1540 HYPH denotes /
T7349 1540-1541 CD denotes 7
T7350 1548-1550 IN denotes to
T7351 1551-1554 PDT denotes all
T7352 1565-1572 NNS denotes bubbles
T7353 1555-1558 DT denotes the
T7354 1559-1564 CD denotes three
T7355 1572-1574 , denotes ,
T7356 1574-1582 IN denotes although
T7357 1640-1642 VBZ denotes is
T7358 1583-1586 DT denotes the
T7359 1587-1595 NN denotes affinity
T7360 1596-1598 IN denotes to
T7361 1599-1604 NN denotes Bub82
T7362 1611-1614 NN denotes DUE
T7363 1604-1605 HYPH denotes /
T7364 1605-1606 NN denotes c
T7365 1607-1610 NN denotes myc
T7366 1606-1607 HYPH denotes -
T7367 1610-1611 HYPH denotes /
T7368 1615-1618 CC denotes and
T7369 1619-1621 IN denotes to
T7370 1622-1627 NN denotes Bub82
T7371 1638-1639 NN denotes C
T7372 1627-1628 HYPH denotes /
T7373 1628-1629 NN denotes c
T7374 1630-1633 NN denotes myc
T7375 1629-1630 HYPH denotes -
T7376 1633-1634 HYPH denotes /
T7377 1634-1637 NN denotes DUE
T7378 1637-1638 HYPH denotes -
T7379 1643-1651 RB denotes slightly
T7380 1652-1657 JJR denotes lower
T7381 1658-1662 IN denotes than
T7382 1663-1667 DT denotes that
T7383 1668-1670 IN denotes to
T7384 1671-1674 NN denotes Bub
T7385 1684-1686 NN denotes B2
T7386 1674-1675 HYPH denotes -
T7387 1675-1677 CD denotes 82
T7388 1677-1678 HYPH denotes /
T7389 1678-1683 NN denotes lamin
T7390 1687-1688 -LRB- denotes (
T7391 1695-1697 NN denotes 7B
T7392 1688-1694 NN denotes Figure
T7393 1697-1698 -RRB- denotes )
T7394 1698-1699 . denotes .
T7395 1699-1792 sentence denotes Therefore, helicase and DNA binding activities do not necessarily correlate with each other.
T7396 1700-1709 RB denotes Therefore
T7397 1766-1775 VB denotes correlate
T7398 1709-1711 , denotes ,
T7399 1711-1719 NN denotes helicase
T7400 1736-1746 NNS denotes activities
T7401 1720-1723 CC denotes and
T7402 1724-1727 NN denotes DNA
T7403 1728-1735 NN denotes binding
T7404 1747-1749 VBP denotes do
T7405 1750-1753 RB denotes not
T7406 1754-1765 RB denotes necessarily
T7407 1776-1780 IN denotes with
T7408 1781-1785 DT denotes each
T7409 1786-1791 JJ denotes other
T7410 1791-1792 . denotes .
T7411 1792-1931 sentence denotes This was also indicated by our previous results that guanine and cytosine stretches can bind to Mcm but cannot activate the helicase (13).
T7412 1793-1797 DT denotes This
T7413 1807-1816 VBN denotes indicated
T7414 1798-1801 VBD denotes was
T7415 1802-1806 RB denotes also
T7416 1817-1819 IN denotes by
T7417 1820-1823 PRP$ denotes our
T7418 1833-1840 NNS denotes results
T7419 1824-1832 JJ denotes previous
T7420 1841-1845 IN denotes that
T7421 1881-1885 VB denotes bind
T7422 1846-1853 NN denotes guanine
T7423 1867-1876 NNS denotes stretches
T7424 1854-1857 CC denotes and
T7425 1858-1866 NN denotes cytosine
T7426 1877-1880 MD denotes can
T7427 1886-1888 IN denotes to
T7428 1889-1892 NN denotes Mcm
T7429 1893-1896 CC denotes but
T7430 1897-1900 MD denotes can
T7431 1904-1912 VB denotes activate
T7432 1900-1903 RB denotes not
T7433 1913-1916 DT denotes the
T7434 1917-1925 NN denotes helicase
T7435 1926-1927 -LRB- denotes (
T7436 1927-1929 CD denotes 13
T7437 1929-1930 -RRB- denotes )
T7438 1930-1931 . denotes .
R4711 T7008 T7009 compound DUE,sequences
R4712 T7009 T7010 nsubj sequences,activate
R4713 T7011 T7009 prep from,sequences
R4714 T7012 T7013 det the,origin
R4715 T7013 T7011 pobj origin,from
R4716 T7014 T7015 compound c,myc
R4717 T7015 T7013 compound myc,origin
R4718 T7016 T7015 punct -,myc
R4719 T7017 T7018 compound Mcm,helicase
R4720 T7018 T7010 dobj helicase,activate
R4721 T7020 T7021 poss Our,studies
R4722 T7021 T7023 nsubj studies,shown
R4723 T7022 T7021 amod previous,studies
R4724 T7024 T7023 aux have,shown
R4725 T7025 T7026 mark that,serve
R4726 T7026 T7023 ccomp serve,shown
R4727 T7027 T7028 det the,sequences
R4728 T7028 T7026 nsubj sequences,serve
R4729 T7029 T7028 acl containing,sequences
R4730 T7030 T7031 amod periodic,tracts
R4731 T7031 T7029 dobj tracts,containing
R4732 T7032 T7033 punct (,n
R4733 T7033 T7031 compound n,tracts
R4734 T7034 T7033 nmod dT,n
R4735 T7035 T7033 punct ),n
R4736 T7036 T7031 acl derived,tracts
R4737 T7037 T7036 prep from,derived
R4738 T7038 T7039 det the,origin
R4739 T7039 T7037 pobj origin,from
R4740 T7040 T7039 amod human,origin
R4741 T7041 T7042 compound lamin,B2
R4742 T7042 T7039 compound B2,origin
R4743 T7043 T7044 punct (,content
R4744 T7044 T7039 parataxis content,origin
R4745 T7045 T7046 nummod 48,%
R4746 T7046 T7044 compound %,content
R4747 T7047 T7044 compound thymine,content
R4748 T7048 T7044 punct ),content
R4749 T7049 T7026 aux can,serve
R4750 T7050 T7026 prep as,serve
R4751 T7051 T7052 det an,activator
R4752 T7052 T7050 pobj activator,as
R4753 T7053 T7052 amod efficient,activator
R4754 T7054 T7052 prep for,activator
R4755 T7055 T7056 det the,helicase
R4756 T7056 T7054 pobj helicase,for
R4757 T7057 T7056 compound Mcm,helicase
R4758 T7058 T7026 prep on,serve
R4759 T7059 T7060 det a,bubble
R4760 T7060 T7058 pobj bubble,on
R4761 T7061 T7023 punct ", ",shown
R4762 T7062 T7023 cc and,shown
R4763 T7063 T7064 nsubj replacement,abolished
R4764 T7064 T7023 conj abolished,shown
R4765 T7065 T7063 prep of,replacement
R4766 T7066 T7065 pobj thymines,of
R4767 T7067 T7063 prep with,replacement
R4768 T7068 T7067 pobj guanines,with
R4769 T7069 T7070 det the,activation
R4770 T7070 T7064 dobj activation,abolished
R4771 T7071 T7070 compound helicase,activation
R4772 T7072 T7073 punct (,28
R4773 T7073 T7064 parataxis 28,abolished
R4774 T7074 T7073 nummod 13,28
R4775 T7075 T7073 punct ",",28
R4776 T7076 T7073 punct ),28
R4777 T7077 T7064 punct .,abolished
R4778 T7079 T7080 prep In,constructed
R4779 T7081 T7079 pobj order,In
R4780 T7082 T7083 aux to,examine
R4781 T7083 T7081 acl examine,order
R4782 T7084 T7085 amod other,origins
R4783 T7085 T7083 dobj origins,examine
R4784 T7086 T7085 amod natural,origins
R4785 T7087 T7085 compound replication,origins
R4786 T7088 T7085 prep with,origins
R4787 T7089 T7090 amod different,contents
R4788 T7090 T7088 pobj contents,with
R4789 T7091 T7090 compound thymine,contents
R4790 T7092 T7083 prep for,examine
R4791 T7093 T7094 det the,ability
R4792 T7094 T7092 pobj ability,for
R4793 T7095 T7096 aux to,activate
R4794 T7096 T7094 acl activate,ability
R4795 T7097 T7098 compound Mcm,helicase
R4796 T7098 T7096 dobj helicase,activate
R4797 T7099 T7096 prep on,activate
R4798 T7100 T7101 det a,substrate
R4799 T7101 T7099 pobj substrate,on
R4800 T7102 T7101 compound bubble,substrate
R4801 T7103 T7080 punct ", ",constructed
R4802 T7104 T7080 nsubj we,constructed
R4803 T7105 T7106 amod new,substrates
R4804 T7106 T7080 dobj substrates,constructed
R4805 T7107 T7106 compound bubble,substrates
R4806 T7108 T7106 punct ", ",substrates
R4807 T7109 T7110 compound Bub82,myc
R4808 T7110 T7106 appos myc,substrates
R4809 T7111 T7110 punct /,myc
R4810 T7112 T7110 compound c,myc
R4811 T7113 T7110 punct -,myc
R4812 T7114 T7106 punct ", ",substrates
R4813 T7115 T7106 acl containing,substrates
R4814 T7116 T7115 dobj sequences,containing
R4815 T7117 T7116 acl derived,sequences
R4816 T7118 T7117 prep from,derived
R4817 T7119 T7120 det the,region
R4818 T7120 T7118 pobj region,from
R4819 T7121 T7120 nmod DUE,region
R4820 T7122 T7121 punct (,DUE
R4821 T7123 T7124 compound DNA,element
R4822 T7124 T7121 appos element,DUE
R4823 T7125 T7124 compound unwinding,element
R4824 T7126 T7120 punct ),region
R4825 T7127 T7120 prep of,region
R4826 T7128 T7129 det the,origin
R4827 T7129 T7127 pobj origin,of
R4828 T7130 T7129 amod human,origin
R4829 T7131 T7132 compound c,myc
R4830 T7132 T7129 compound myc,origin
R4831 T7133 T7132 punct -,myc
R4832 T7134 T7135 dep which,is
R4833 T7135 T7120 relcl is,region
R4834 T7136 T7135 acomp essential,is
R4835 T7137 T7136 prep for,essential
R4836 T7138 T7139 compound c,myc
R4837 T7139 T7141 compound myc,activity
R4838 T7140 T7139 punct -,myc
R4839 T7141 T7137 pobj activity,for
R4840 T7142 T7141 compound replicator,activity
R4841 T7143 T7144 punct (,30
R4842 T7144 T7135 parataxis 30,is
R4843 T7145 T7144 nummod 29,30
R4844 T7146 T7144 punct ",",30
R4845 T7147 T7144 punct ),30
R4846 T7148 T7080 punct .,constructed
R4847 T7150 T7151 det The,segment
R4848 T7151 T7153 nsubj segment,contains
R4849 T7152 T7151 amod unpaired,segment
R4850 T7154 T7151 prep in,segment
R4851 T7155 T7156 compound Bub82,DUE
R4852 T7156 T7154 pobj DUE,in
R4853 T7157 T7156 punct /,DUE
R4854 T7158 T7159 compound c,myc
R4855 T7159 T7156 compound myc,DUE
R4856 T7160 T7159 punct -,myc
R4857 T7161 T7156 punct /,DUE
R4858 T7162 T7163 nummod one,strand
R4859 T7163 T7153 dobj strand,contains
R4860 T7164 T7163 prep of,strand
R4861 T7165 T7164 pobj DUE,of
R4862 T7166 T7153 cc and,contains
R4863 T7167 T7168 nsubj that,contains
R4864 T7168 T7153 conj contains,contains
R4865 T7169 T7167 prep in,that
R4866 T7170 T7171 compound Bub82,C
R4867 T7171 T7169 pobj C,in
R4868 T7172 T7171 punct /,C
R4869 T7173 T7174 compound c,myc
R4870 T7174 T7171 compound myc,C
R4871 T7175 T7174 punct -,myc
R4872 T7176 T7171 punct /,C
R4873 T7177 T7171 compound DUE,C
R4874 T7178 T7171 punct -,C
R4875 T7179 T7180 det another,strand
R4876 T7180 T7168 dobj strand,contains
R4877 T7181 T7168 punct .,contains
R4878 T7183 T7184 det This,DUE
R4879 T7184 T7185 nsubjpass DUE,believed
R4880 T7186 T7185 auxpass is,believed
R4881 T7187 T7188 aux to,coincide
R4882 T7188 T7185 xcomp coincide,believed
R4883 T7189 T7188 prep with,coincide
R4884 T7190 T7191 det the,region
R4885 T7191 T7189 pobj region,with
R4886 T7192 T7193 advmod initially,unwound
R4887 T7193 T7191 amod unwound,region
R4888 T7194 T7191 prep of,region
R4889 T7195 T7196 det the,origin
R4890 T7196 T7194 pobj origin,of
R4891 T7197 T7198 compound c,myc
R4892 T7198 T7196 compound myc,origin
R4893 T7199 T7198 punct -,myc
R4894 T7200 T7201 punct (,29
R4895 T7201 T7188 parataxis 29,coincide
R4896 T7202 T7201 punct ),29
R4897 T7203 T7185 punct ", ",believed
R4898 T7204 T7185 cc and,believed
R4899 T7205 T7206 poss its,deletion
R4900 T7206 T7207 nsubj deletion,reduced
R4901 T7207 T7185 conj reduced,believed
R4902 T7208 T7207 advmod substantially,reduced
R4903 T7209 T7210 det the,activity
R4904 T7210 T7207 dobj activity,reduced
R4905 T7211 T7210 compound replicator,activity
R4906 T7212 T7213 punct (,30
R4907 T7213 T7207 parataxis 30,reduced
R4908 T7214 T7213 punct ),30
R4909 T7215 T7207 punct .,reduced
R4910 T7217 T7218 nsubj Mcm4,unwound
R4911 T7219 T7217 punct /,Mcm4
R4912 T7220 T7217 nummod 6,Mcm4
R4913 T7221 T7217 punct /,Mcm4
R4914 T7222 T7217 nummod 7,Mcm4
R4915 T7223 T7224 compound Bub82,B2
R4916 T7224 T7218 dobj B2,unwound
R4917 T7225 T7224 punct /,B2
R4918 T7226 T7224 compound lamin,B2
R4919 T7227 T7228 punct (,%
R4920 T7228 T7224 parataxis %,B2
R4921 T7229 T7228 nmod thymine,%
R4922 T7230 T7228 nummod 48,%
R4923 T7231 T7228 punct ),%
R4924 T7232 T7224 punct ", ",B2
R4925 T7233 T7234 compound Bub82,DUE
R4926 T7234 T7224 conj DUE,B2
R4927 T7235 T7234 punct /,DUE
R4928 T7236 T7237 compound c,myc
R4929 T7237 T7234 compound myc,DUE
R4930 T7238 T7237 punct -,myc
R4931 T7239 T7234 punct /,DUE
R4932 T7240 T7241 punct (,%
R4933 T7241 T7234 parataxis %,DUE
R4934 T7242 T7241 nummod 37,%
R4935 T7243 T7241 punct ),%
R4936 T7244 T7234 cc and,DUE
R4937 T7245 T7246 compound Bub82,C
R4938 T7246 T7234 conj C,DUE
R4939 T7247 T7246 punct /,C
R4940 T7248 T7249 compound c,myc
R4941 T7249 T7246 compound myc,C
R4942 T7250 T7249 punct -,myc
R4943 T7251 T7246 punct /,C
R4944 T7252 T7246 compound DUE,C
R4945 T7253 T7246 punct -,C
R4946 T7254 T7255 punct (,%
R4947 T7255 T7246 parataxis %,C
R4948 T7256 T7255 nummod 39,%
R4949 T7257 T7255 punct ),%
R4950 T7258 T7218 prep with,unwound
R4951 T7259 T7260 amod similar,efficiency
R4952 T7260 T7258 pobj efficiency,with
R4953 T7261 T7262 punct (,7A
R4954 T7262 T7260 parataxis 7A,efficiency
R4955 T7263 T7262 compound Figure,7A
R4956 T7264 T7262 punct ),7A
R4957 T7265 T7218 punct ", ",unwound
R4958 T7266 T7218 advcl indicating,unwound
R4959 T7267 T7268 mark that,serve
R4960 T7268 T7266 ccomp serve,indicating
R4961 T7269 T7270 det the,sequences
R4962 T7270 T7268 nsubj sequences,serve
R4963 T7271 T7270 prep from,sequences
R4964 T7272 T7273 det the,origin
R4965 T7273 T7271 pobj origin,from
R4966 T7274 T7275 compound c,myc
R4967 T7275 T7273 compound myc,origin
R4968 T7276 T7275 punct -,myc
R4969 T7277 T7268 advmod also,serve
R4970 T7278 T7268 aux can,serve
R4971 T7279 T7268 prep as,serve
R4972 T7280 T7281 amod efficient,activators
R4973 T7281 T7279 pobj activators,as
R4974 T7282 T7281 prep of,activators
R4975 T7283 T7284 det the,helicase
R4976 T7284 T7282 pobj helicase,of
R4977 T7285 T7284 compound Mcm,helicase
R4978 T7286 T7218 punct .,unwound
R4979 T7288 T7289 det This,result
R4980 T7289 T7290 nsubj result,indicates
R4981 T7291 T7290 advmod also,indicates
R4982 T7292 T7293 mark that,activate
R4983 T7293 T7290 ccomp activate,indicates
R4984 T7294 T7293 nsubj sequences,activate
R4985 T7295 T7294 prep with,sequences
R4986 T7296 T7297 nummod 37,%
R4987 T7297 T7298 compound %,content
R4988 T7298 T7295 pobj content,with
R4989 T7299 T7298 compound thymine,content
R4990 T7300 T7293 aux can,activate
R4991 T7301 T7293 dobj Mcm4,activate
R4992 T7302 T7301 punct /,Mcm4
R4993 T7303 T7301 nummod 6,Mcm4
R4994 T7304 T7301 punct /,Mcm4
R4995 T7305 T7301 nummod 7,Mcm4
R4996 T7306 T7307 aux to,displace
R4997 T7307 T7293 advcl displace,activate
R4998 T7308 T7309 nummod 24,nt
R4999 T7309 T7310 compound nt,duplex
R5000 T7310 T7307 dobj duplex,displace
R5001 T7311 T7307 prep on,displace
R5002 T7312 T7313 det both,sides
R5003 T7313 T7311 pobj sides,on
R5004 T7314 T7307 prep in,displace
R5005 T7315 T7316 det a,substrate
R5006 T7316 T7314 pobj substrate,in
R5007 T7317 T7316 compound bubble,substrate
R5008 T7318 T7293 punct ", ",activate
R5009 T7319 T7293 advcl suggesting,activate
R5010 T7320 T7321 mark that,affect
R5011 T7321 T7319 ccomp affect,suggesting
R5012 T7322 T7323 det the,content
R5013 T7323 T7321 nsubj content,affect
R5014 T7324 T7323 preconj not,content
R5015 T7325 T7324 advmod only,not
R5016 T7326 T7323 compound thymine,content
R5017 T7327 T7323 cc but,content
R5018 T7328 T7327 advmod also,but
R5019 T7329 T7330 det the,context
R5020 T7330 T7323 conj context,content
R5021 T7331 T7330 compound sequence,context
R5022 T7332 T7321 aux may,affect
R5023 T7333 T7334 det the,activation
R5024 T7334 T7321 dobj activation,affect
R5025 T7335 T7336 compound Mcm,helicase
R5026 T7336 T7334 compound helicase,activation
R5027 T7337 T7290 punct .,indicates
R5028 T7339 T7340 prep In,bound
R5029 T7341 T7342 compound gel,shift
R5030 T7342 T7343 compound shift,assays
R5031 T7343 T7339 pobj assays,In
R5032 T7344 T7340 punct ", ",bound
R5033 T7345 T7340 nsubj MCM4,bound
R5034 T7346 T7345 punct /,MCM4
R5035 T7347 T7345 nummod 6,MCM4
R5036 T7348 T7345 punct /,MCM4
R5037 T7349 T7345 nummod 7,MCM4
R5038 T7350 T7340 prep to,bound
R5039 T7351 T7352 predet all,bubbles
R5040 T7352 T7350 pobj bubbles,to
R5041 T7353 T7352 det the,bubbles
R5042 T7354 T7352 nummod three,bubbles
R5043 T7355 T7340 punct ", ",bound
R5044 T7356 T7357 mark although,is
R5045 T7357 T7340 advcl is,bound
R5046 T7358 T7359 det the,affinity
R5047 T7359 T7357 nsubj affinity,is
R5048 T7360 T7359 prep to,affinity
R5049 T7361 T7362 compound Bub82,DUE
R5050 T7362 T7360 pobj DUE,to
R5051 T7363 T7362 punct /,DUE
R5052 T7364 T7365 compound c,myc
R5053 T7365 T7362 compound myc,DUE
R5054 T7366 T7365 punct -,myc
R5055 T7367 T7362 punct /,DUE
R5056 T7368 T7360 cc and,to
R5057 T7369 T7360 conj to,to
R5058 T7370 T7371 compound Bub82,C
R5059 T7371 T7369 pobj C,to
R5060 T7372 T7371 punct /,C
R5061 T7373 T7374 compound c,myc
R5062 T7374 T7371 compound myc,C
R5063 T7375 T7374 punct -,myc
R5064 T7376 T7371 punct /,C
R5065 T7377 T7371 compound DUE,C
R5066 T7378 T7371 punct -,C
R5067 T7379 T7380 advmod slightly,lower
R5068 T7380 T7357 acomp lower,is
R5069 T7381 T7380 prep than,lower
R5070 T7382 T7381 pobj that,than
R5071 T7383 T7382 prep to,that
R5072 T7384 T7385 nmod Bub,B2
R5073 T7385 T7383 pobj B2,to
R5074 T7386 T7385 punct -,B2
R5075 T7387 T7385 nummod 82,B2
R5076 T7388 T7385 punct /,B2
R5077 T7389 T7385 compound lamin,B2
R5078 T7390 T7391 punct (,7B
R5079 T7391 T7357 parataxis 7B,is
R5080 T7392 T7391 compound Figure,7B
R5081 T7393 T7391 punct ),7B
R5082 T7394 T7340 punct .,bound
R5083 T7396 T7397 advmod Therefore,correlate
R5084 T7398 T7397 punct ", ",correlate
R5085 T7399 T7400 nmod helicase,activities
R5086 T7400 T7397 nsubj activities,correlate
R5087 T7401 T7399 cc and,helicase
R5088 T7402 T7403 compound DNA,binding
R5089 T7403 T7399 conj binding,helicase
R5090 T7404 T7397 aux do,correlate
R5091 T7405 T7397 neg not,correlate
R5092 T7406 T7397 advmod necessarily,correlate
R5093 T7407 T7397 prep with,correlate
R5094 T7408 T7409 det each,other
R5095 T7409 T7407 pobj other,with
R5096 T7410 T7397 punct .,correlate
R5097 T7412 T7413 nsubjpass This,indicated
R5098 T7414 T7413 auxpass was,indicated
R5099 T7415 T7413 advmod also,indicated
R5100 T7416 T7413 agent by,indicated
R5101 T7417 T7418 poss our,results
R5102 T7418 T7416 pobj results,by
R5103 T7419 T7418 amod previous,results
R5104 T7420 T7421 mark that,bind
R5105 T7421 T7418 acl bind,results
R5106 T7422 T7423 nmod guanine,stretches
R5107 T7423 T7421 nsubj stretches,bind
R5108 T7424 T7422 cc and,guanine
R5109 T7425 T7422 conj cytosine,guanine
R5110 T7426 T7421 aux can,bind
R5111 T7427 T7421 prep to,bind
R5112 T7428 T7427 pobj Mcm,to
R5113 T7429 T7421 cc but,bind
R5114 T7430 T7431 aux can,activate
R5115 T7431 T7421 conj activate,bind
R5116 T7432 T7431 neg not,activate
R5117 T7433 T7434 det the,helicase
R5118 T7434 T7431 dobj helicase,activate
R5119 T7435 T7436 punct (,13
R5120 T7436 T7431 parataxis 13,activate
R5121 T7437 T7436 punct ),13
R5122 T7438 T7413 punct .,indicated

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T6936 4-13 SO_EXT:biological_sequence denotes sequences
T6937 23-28 PR_EXT:000000084 denotes c-myc
T6938 29-35 SO_EXT:0000296 denotes origin
T6939 45-48 GO:0042555 denotes Mcm
T6940 49-57 GO_EXT:0004386 denotes helicase
T6941 99-108 SO_EXT:biological_sequence denotes sequences
T6942 130-132 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes dT
T6943 159-164 NCBITaxon:9606 denotes human
T6944 165-173 PR_EXT:000009861 denotes lamin B2
T6945 174-180 SO_EXT:0000296 denotes origin
T6946 186-193 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T6947 247-250 GO:0042555 denotes Mcm
T6948 251-259 GO_EXT:0004386 denotes helicase
T6949 277-288 SO_EXT:sequence_substitution_entity_or_process denotes replacement
T6950 292-300 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymines
T6951 306-314 CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes guanines
T6952 329-337 GO_EXT:0004386 denotes helicase
T6953 392-403 GO:0006260 denotes replication
T6954 392-411 SO_EXT:0000296 denotes replication origins
T6955 427-434 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T6956 472-475 GO:0042555 denotes Mcm
T6957 476-484 GO_EXT:0004386 denotes helicase
T6958 552-557 PR_EXT:000000084 denotes c-myc
T6959 570-579 SO_EXT:biological_sequence denotes sequences
T6960 602-605 CHEBI_SO_EXT:DNA denotes DNA
T6961 602-615 GO:0032508 denotes DNA unwinding
T6962 639-644 NCBITaxon:9606 denotes human
T6963 645-650 PR_EXT:000000084 denotes c-myc
T6964 651-657 SO_EXT:0000296 denotes origin
T6965 681-686 PR_EXT:000000084 denotes c-myc
T6966 687-697 GO_EXT:DNA_replicator denotes replicator
T6967 720-728 SO:0000984 denotes unpaired
T6968 746-751 PR_EXT:000000084 denotes c-myc
T6969 801-806 PR_EXT:000000084 denotes c-myc
T6970 912-917 PR_EXT:000000084 denotes c-myc
T6971 918-924 SO_EXT:0000296 denotes origin
T6972 939-947 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T6973 974-984 GO_EXT:DNA_replicator denotes replicator
T6974 1000-1004 PR_EXT:000010246 denotes Mcm4
T6975 1000-1008 GO:0097373 denotes Mcm4/6/7
T6976 1023-1031 PR_EXT:000009861 denotes lamin B2
T6977 1033-1040 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T6978 1053-1058 PR_EXT:000000084 denotes c-myc
T6979 1079-1084 PR_EXT:000000084 denotes c-myc
T6980 1154-1163 SO_EXT:biological_sequence denotes sequences
T6981 1173-1178 PR_EXT:000000084 denotes c-myc
T6982 1179-1185 SO_EXT:0000296 denotes origin
T6983 1232-1235 GO:0042555 denotes Mcm
T6984 1236-1244 GO_EXT:0004386 denotes helicase
T6985 1278-1287 SO_EXT:biological_sequence denotes sequences
T6986 1297-1304 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T6987 1326-1330 PR_EXT:000010246 denotes Mcm4
T6988 1326-1334 GO:0097373 denotes Mcm4/6/7
T6989 1350-1352 CHEBI_SO_EXT:nucleotide denotes nt
T6990 1426-1433 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T6991 1455-1463 SO_EXT:biological_sequence denotes sequence
T6992 1487-1490 GO:0042555 denotes Mcm
T6993 1491-1499 GO_EXT:0004386 denotes helicase
T6994 1533-1537 PR_EXT:000010246 denotes MCM4
T6995 1533-1541 GO:0097373 denotes MCM4/6/7
T6996 1542-1547 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bound
T6997 1605-1610 PR_EXT:000000084 denotes c-myc
T6998 1628-1633 PR_EXT:000000084 denotes c-myc
T6999 1678-1686 PR_EXT:000009861 denotes lamin B2
T7000 1711-1719 GO_EXT:0004386 denotes helicase
T7001 1724-1727 CHEBI_SO_EXT:DNA denotes DNA
T7002 1728-1735 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T7003 1846-1853 CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes guanine
T7004 1858-1866 CHEBI_EXT:cytosine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes cytosine
T7005 1881-1885 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bind
T7006 1889-1892 GO:0042555 denotes Mcm
T7007 1917-1925 GO_EXT:0004386 denotes helicase

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T6898 23-28 PR:000000084 denotes c-myc
T6899 29-35 SO:0000296 denotes origin
T6900 45-48 GO:0042555 denotes Mcm
T6901 159-164 NCBITaxon:9606 denotes human
T6902 165-173 PR:000009861 denotes lamin B2
T6903 174-180 SO:0000296 denotes origin
T6904 247-250 GO:0042555 denotes Mcm
T6905 392-403 GO:0006260 denotes replication
T6906 392-411 SO:0000296 denotes replication origins
T6907 472-475 GO:0042555 denotes Mcm
T6908 552-557 PR:000000084 denotes c-myc
T6909 602-615 GO:0032508 denotes DNA unwinding
T6910 639-644 NCBITaxon:9606 denotes human
T6911 645-650 PR:000000084 denotes c-myc
T6912 651-657 SO:0000296 denotes origin
T6913 681-686 PR:000000084 denotes c-myc
T6914 720-728 SO:0000984 denotes unpaired
T6915 746-751 PR:000000084 denotes c-myc
T6916 801-806 PR:000000084 denotes c-myc
T6917 912-917 PR:000000084 denotes c-myc
T6918 918-924 SO:0000296 denotes origin
T6919 1000-1004 PR:000010246 denotes Mcm4
T6920 1000-1008 GO:0097373 denotes Mcm4/6/7
T6921 1023-1031 PR:000009861 denotes lamin B2
T6922 1053-1058 PR:000000084 denotes c-myc
T6923 1079-1084 PR:000000084 denotes c-myc
T6924 1173-1178 PR:000000084 denotes c-myc
T6925 1179-1185 SO:0000296 denotes origin
T6926 1232-1235 GO:0042555 denotes Mcm
T6927 1326-1330 PR:000010246 denotes Mcm4
T6928 1326-1334 GO:0097373 denotes Mcm4/6/7
T6929 1487-1490 GO:0042555 denotes Mcm
T6930 1533-1537 PR:000010246 denotes MCM4
T6931 1533-1541 GO:0097373 denotes MCM4/6/7
T6932 1605-1610 PR:000000084 denotes c-myc
T6933 1628-1633 PR:000000084 denotes c-myc
T6934 1678-1686 PR:000009861 denotes lamin B2
T6935 1889-1892 GO:0042555 denotes Mcm

2_test

Id Subject Object Predicate Lexical cue
15917436-14609960-76775523 350-352 14609960 denotes 13
15917436-10720330-76775524 353-355 10720330 denotes 28
15917436-7935372-76775525 708-710 7935372 denotes 29
15917436-12589000-76775526 711-713 12589000 denotes 30
15917436-7935372-76775527 926-928 7935372 denotes 29
15917436-12589000-76775528 995-997 12589000 denotes 30
15917436-14609960-76775529 1927-1929 14609960 denotes 13