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PMC:1140370 / 20617-22640 JSONTXT

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Id Subject Object Predicate Lexical cue
T6404 0-3 DT denotes The
T6405 4-11 NNS denotes effects
T6406 12-14 IN denotes of
T6407 15-18 DT denotes the
T6408 27-34 NN denotes content
T6409 19-26 NN denotes thymine
T6410 35-37 IN denotes of
T6411 38-41 DT denotes the
T6412 45-49 NN denotes tail
T6413 42-43 CD denotes 3
T6414 43-44 SYM denotes ′
T6415 44-45 HYPH denotes -
T6416 50-52 IN denotes on
T6417 53-56 NN denotes Mcm
T6418 57-65 NN denotes helicase
T6419 66-74 NN denotes activity
T6420 74-211 sentence denotes We next examined more systematically the effect of the compositions of the thymine residues of the 3′-tail on the Mcm helicase activity.
T6421 75-77 PRP denotes We
T6422 83-91 VBD denotes examined
T6423 78-82 RB denotes next
T6424 92-96 RBR denotes more
T6425 97-111 RB denotes systematically
T6426 112-115 DT denotes the
T6427 116-122 NN denotes effect
T6428 123-125 IN denotes of
T6429 126-129 DT denotes the
T6430 130-142 NNS denotes compositions
T6431 143-145 IN denotes of
T6432 146-149 DT denotes the
T6433 158-166 NNS denotes residues
T6434 150-157 NN denotes thymine
T6435 167-169 IN denotes of
T6436 170-173 DT denotes the
T6437 177-181 NN denotes tail
T6438 174-175 CD denotes 3
T6439 175-176 SYM denotes ′
T6440 176-177 HYPH denotes -
T6441 182-184 IN denotes on
T6442 185-188 DT denotes the
T6443 202-210 NN denotes activity
T6444 189-192 NN denotes Mcm
T6445 193-201 NN denotes helicase
T6446 210-211 . denotes .
T6447 211-458 sentence denotes A partial heteroduplex M13 single-stranded DNA containing a 37 bp duplex region in the presence or absence of the 50 nt long 3′-tail of various nucleotide compositions were constructed and the unwinding by mouse Mcm4/6/7 was examined (Figure 6A).
T6448 212-213 DT denotes A
T6449 255-258 NN denotes DNA
T6450 214-221 JJ denotes partial
T6451 222-234 NN denotes heteroduplex
T6452 235-238 NN denotes M13
T6453 239-245 JJ denotes single
T6454 246-254 VBN denotes stranded
T6455 245-246 HYPH denotes -
T6456 385-396 VBN denotes constructed
T6457 259-269 VBG denotes containing
T6458 270-271 DT denotes a
T6459 285-291 NN denotes region
T6460 272-274 CD denotes 37
T6461 275-277 NN denotes bp
T6462 278-284 NN denotes duplex
T6463 292-294 IN denotes in
T6464 295-298 DT denotes the
T6465 299-307 NN denotes presence
T6466 308-310 CC denotes or
T6467 311-318 NN denotes absence
T6468 319-321 IN denotes of
T6469 322-325 DT denotes the
T6470 340-344 NN denotes tail
T6471 326-328 CD denotes 50
T6472 329-331 NN denotes nt
T6473 332-336 JJ denotes long
T6474 337-338 CD denotes 3
T6475 338-339 SYM denotes ′
T6476 339-340 HYPH denotes -
T6477 345-347 IN denotes of
T6478 348-355 JJ denotes various
T6479 367-379 NNS denotes compositions
T6480 356-366 NN denotes nucleotide
T6481 380-384 VBD denotes were
T6482 397-400 CC denotes and
T6483 401-404 DT denotes the
T6484 405-414 NN denotes unwinding
T6485 437-445 VBN denotes examined
T6486 415-417 IN denotes by
T6487 418-423 NN denotes mouse
T6488 424-428 NN denotes Mcm4
T6489 428-429 HYPH denotes /
T6490 429-430 CD denotes 6
T6491 430-431 HYPH denotes /
T6492 431-432 CD denotes 7
T6493 433-436 VBD denotes was
T6494 446-447 -LRB- denotes (
T6495 454-456 NN denotes 6A
T6496 447-453 NN denotes Figure
T6497 456-457 -RRB- denotes )
T6498 457-458 . denotes .
T6499 458-586 sentence denotes Due to its low processivity, Mcm4/6/7 barely displaced the annealed 37mer oligonucleotide without a 3′-tail (37mer; Figure 6A).
T6500 459-462 IN denotes Due
T6501 504-513 VBD denotes displaced
T6502 463-465 IN denotes to
T6503 466-469 PRP$ denotes its
T6504 474-486 NN denotes processivity
T6505 470-473 JJ denotes low
T6506 486-488 , denotes ,
T6507 488-492 NN denotes Mcm4
T6508 492-493 HYPH denotes /
T6509 493-494 CD denotes 6
T6510 494-495 HYPH denotes /
T6511 495-496 CD denotes 7
T6512 497-503 RB denotes barely
T6513 514-517 DT denotes the
T6514 533-548 NN denotes oligonucleotide
T6515 518-526 JJ denotes annealed
T6516 527-532 NN denotes 37mer
T6517 549-556 IN denotes without
T6518 557-558 DT denotes a
T6519 562-566 NN denotes tail
T6520 559-560 CD denotes 3
T6521 560-561 SYM denotes ′
T6522 561-562 HYPH denotes -
T6523 567-568 -LRB- denotes (
T6524 582-584 NN denotes 6A
T6525 568-573 NN denotes 37mer
T6526 573-574 : denotes ;
T6527 575-581 NN denotes Figure
T6528 584-585 -RRB- denotes )
T6529 585-586 . denotes .
T6530 586-779 sentence denotes Only weak helicase activity was observed on the substrate carrying the 3′-tail of 25 repeats of TA dinucleotide (37-TA25; Figure 6A), whereas strong helicase activity was observed on 37-TTA17.
T6531 587-591 RB denotes Only
T6532 606-614 NN denotes activity
T6533 592-596 JJ denotes weak
T6534 597-605 NN denotes helicase
T6535 619-627 VBN denotes observed
T6536 615-618 VBD denotes was
T6537 628-630 IN denotes on
T6538 631-634 DT denotes the
T6539 635-644 NN denotes substrate
T6540 645-653 VBG denotes carrying
T6541 654-657 DT denotes the
T6542 661-665 NN denotes tail
T6543 658-659 CD denotes 3
T6544 659-660 SYM denotes ′
T6545 660-661 HYPH denotes -
T6546 666-668 IN denotes of
T6547 669-671 CD denotes 25
T6548 672-679 NNS denotes repeats
T6549 680-682 IN denotes of
T6550 683-685 NN denotes TA
T6551 686-698 NN denotes dinucleotide
T6552 699-700 -LRB- denotes (
T6553 716-718 NN denotes 6A
T6554 700-702 CD denotes 37
T6555 703-707 NN denotes TA25
T6556 702-703 HYPH denotes -
T6557 707-708 : denotes ;
T6558 709-715 NN denotes Figure
T6559 718-719 -RRB- denotes )
T6560 719-721 , denotes ,
T6561 721-728 IN denotes whereas
T6562 758-766 VBN denotes observed
T6563 729-735 JJ denotes strong
T6564 745-753 NN denotes activity
T6565 736-744 NN denotes helicase
T6566 754-757 VBD denotes was
T6567 767-769 IN denotes on
T6568 770-772 CD denotes 37
T6569 773-778 NN denotes TTA17
T6570 772-773 HYPH denotes -
T6571 778-779 . denotes .
T6572 779-1029 sentence denotes Increase of thymine content on the 3′-tail did not further increase the extent of unwinding (37-TTTA13, 37-TTTTA10 and 37-T50; Figure 6A), suggesting that 17 repeats of TT dinucleotides (67% thymine) may be sufficient for activation of Mcm helicase.
T6573 780-788 NN denotes Increase
T6574 839-847 VB denotes increase
T6575 789-791 IN denotes of
T6576 792-799 NN denotes thymine
T6577 800-807 NN denotes content
T6578 808-810 IN denotes on
T6579 811-814 DT denotes the
T6580 818-822 NN denotes tail
T6581 815-816 CD denotes 3
T6582 816-817 SYM denotes ′
T6583 817-818 HYPH denotes -
T6584 823-826 VBD denotes did
T6585 827-830 RB denotes not
T6586 831-838 RB denotes further
T6587 848-851 DT denotes the
T6588 852-858 NN denotes extent
T6589 859-861 IN denotes of
T6590 862-871 NN denotes unwinding
T6591 872-873 -LRB- denotes (
T6592 914-916 NN denotes 6A
T6593 873-875 CD denotes 37
T6594 876-882 NN denotes TTTA13
T6595 875-876 HYPH denotes -
T6596 882-884 , denotes ,
T6597 884-886 CD denotes 37
T6598 887-894 NN denotes TTTTA10
T6599 886-887 HYPH denotes -
T6600 895-898 CC denotes and
T6601 899-901 CD denotes 37
T6602 902-905 NN denotes T50
T6603 901-902 HYPH denotes -
T6604 905-906 : denotes ;
T6605 907-913 NN denotes Figure
T6606 916-917 -RRB- denotes )
T6607 917-919 , denotes ,
T6608 919-929 VBG denotes suggesting
T6609 930-934 IN denotes that
T6610 984-986 VB denotes be
T6611 935-937 CD denotes 17
T6612 938-945 NNS denotes repeats
T6613 946-948 IN denotes of
T6614 949-951 NN denotes TT
T6615 952-965 NNS denotes dinucleotides
T6616 966-967 -LRB- denotes (
T6617 971-978 NN denotes thymine
T6618 967-969 CD denotes 67
T6619 969-970 NN denotes %
T6620 978-979 -RRB- denotes )
T6621 980-983 MD denotes may
T6622 987-997 JJ denotes sufficient
T6623 998-1001 IN denotes for
T6624 1002-1012 NN denotes activation
T6625 1013-1015 IN denotes of
T6626 1016-1019 NN denotes Mcm
T6627 1020-1028 NN denotes helicase
T6628 1028-1029 . denotes .
T6629 1029-1230 sentence denotes It should be noted that the TA25 tail would self-anneal and this would prevent the loading of Mcm, since the 3′-tail containing TTAA13 or TTTAAA8 did not enhance the unwinding either (data not shown).
T6630 1030-1032 PRP denotes It
T6631 1043-1048 VBN denotes noted
T6632 1033-1039 MD denotes should
T6633 1040-1042 VB denotes be
T6634 1049-1053 IN denotes that
T6635 1079-1085 VB denotes anneal
T6636 1054-1057 DT denotes the
T6637 1063-1067 NN denotes tail
T6638 1058-1062 NN denotes TA25
T6639 1068-1073 MD denotes would
T6640 1074-1078 NN denotes self
T6641 1078-1079 HYPH denotes -
T6642 1086-1089 CC denotes and
T6643 1090-1094 DT denotes this
T6644 1101-1108 VB denotes prevent
T6645 1095-1100 MD denotes would
T6646 1109-1112 DT denotes the
T6647 1113-1120 NN denotes loading
T6648 1121-1123 IN denotes of
T6649 1124-1127 NN denotes Mcm
T6650 1127-1129 , denotes ,
T6651 1129-1134 IN denotes since
T6652 1184-1191 VB denotes enhance
T6653 1135-1138 DT denotes the
T6654 1142-1146 NN denotes tail
T6655 1139-1140 CD denotes 3
T6656 1140-1141 SYM denotes ′
T6657 1141-1142 HYPH denotes -
T6658 1147-1157 VBG denotes containing
T6659 1158-1164 NN denotes TTAA13
T6660 1165-1167 CC denotes or
T6661 1168-1175 NN denotes TTTAAA8
T6662 1176-1179 VBD denotes did
T6663 1180-1183 RB denotes not
T6664 1192-1195 DT denotes the
T6665 1196-1205 NN denotes unwinding
T6666 1206-1212 RB denotes either
T6667 1213-1214 -LRB- denotes (
T6668 1223-1228 VBN denotes shown
T6669 1214-1218 NNS denotes data
T6670 1219-1222 RB denotes not
T6671 1228-1229 -RRB- denotes )
T6672 1229-1230 . denotes .
T6673 1230-1330 sentence denotes Therefore, we next examined the effects of repeating sequences of thymine and cytosine (Figure 6B).
T6674 1231-1240 RB denotes Therefore
T6675 1250-1258 VBD denotes examined
T6676 1240-1242 , denotes ,
T6677 1242-1244 PRP denotes we
T6678 1245-1249 RB denotes next
T6679 1259-1262 DT denotes the
T6680 1263-1270 NNS denotes effects
T6681 1271-1273 IN denotes of
T6682 1274-1283 VBG denotes repeating
T6683 1284-1293 NNS denotes sequences
T6684 1294-1296 IN denotes of
T6685 1297-1304 NN denotes thymine
T6686 1305-1308 CC denotes and
T6687 1309-1317 NN denotes cytosine
T6688 1318-1319 -LRB- denotes (
T6689 1326-1328 NN denotes 6B
T6690 1319-1325 NN denotes Figure
T6691 1328-1329 -RRB- denotes )
T6692 1329-1330 . denotes .
T6693 1330-1604 sentence denotes Partial heteroduplex substrates containing the 3′-tail of TC25, TTCC13, TTTCCC8, TTTTCCCC6, TTCC17 were displaced by the Mcm4/6/7 complex to the extent similar to that achieved by TTA17, suggesting that 50% thymine content is sufficient for full activation of Mcm helicase.
T6694 1331-1338 JJ denotes Partial
T6695 1352-1362 NNS denotes substrates
T6696 1339-1351 NN denotes heteroduplex
T6697 1435-1444 VBN denotes displaced
T6698 1363-1373 VBG denotes containing
T6699 1374-1377 DT denotes the
T6700 1381-1385 NN denotes tail
T6701 1378-1379 CD denotes 3
T6702 1379-1380 SYM denotes ′
T6703 1380-1381 HYPH denotes -
T6704 1386-1388 IN denotes of
T6705 1389-1393 NN denotes TC25
T6706 1423-1429 NN denotes TTCC17
T6707 1393-1395 , denotes ,
T6708 1395-1401 NN denotes TTCC13
T6709 1401-1403 , denotes ,
T6710 1403-1410 NN denotes TTTCCC8
T6711 1410-1412 , denotes ,
T6712 1412-1421 NN denotes TTTTCCCC6
T6713 1421-1423 , denotes ,
T6714 1430-1434 VBD denotes were
T6715 1445-1447 IN denotes by
T6716 1448-1451 DT denotes the
T6717 1461-1468 NN denotes complex
T6718 1452-1456 NN denotes Mcm4
T6719 1456-1457 HYPH denotes /
T6720 1457-1458 CD denotes 6
T6721 1458-1459 HYPH denotes /
T6722 1459-1460 CD denotes 7
T6723 1469-1471 IN denotes to
T6724 1472-1475 DT denotes the
T6725 1476-1482 NN denotes extent
T6726 1483-1490 JJ denotes similar
T6727 1491-1493 IN denotes to
T6728 1494-1498 DT denotes that
T6729 1499-1507 VBN denotes achieved
T6730 1508-1510 IN denotes by
T6731 1511-1516 NN denotes TTA17
T6732 1516-1518 , denotes ,
T6733 1518-1528 VBG denotes suggesting
T6734 1529-1533 IN denotes that
T6735 1554-1556 VBZ denotes is
T6736 1534-1536 CD denotes 50
T6737 1536-1537 NN denotes %
T6738 1546-1553 NN denotes content
T6739 1538-1545 NN denotes thymine
T6740 1557-1567 JJ denotes sufficient
T6741 1568-1571 IN denotes for
T6742 1572-1576 JJ denotes full
T6743 1577-1587 NN denotes activation
T6744 1588-1590 IN denotes of
T6745 1591-1594 NN denotes Mcm
T6746 1595-1603 NN denotes helicase
T6747 1603-1604 . denotes .
T6748 1604-1746 sentence denotes TTCC13 and TTCC17 were displaced to a similar extent, consistent with the earlier result that a 40 nt tail is sufficient for activation (13).
T6749 1605-1611 NN denotes TTCC13
T6750 1628-1637 VBN denotes displaced
T6751 1612-1615 CC denotes and
T6752 1616-1622 NN denotes TTCC17
T6753 1623-1627 VBD denotes were
T6754 1638-1640 IN denotes to
T6755 1641-1642 DT denotes a
T6756 1651-1657 NN denotes extent
T6757 1643-1650 JJ denotes similar
T6758 1657-1659 , denotes ,
T6759 1659-1669 JJ denotes consistent
T6760 1670-1674 IN denotes with
T6761 1675-1678 DT denotes the
T6762 1687-1693 NN denotes result
T6763 1679-1686 JJR denotes earlier
T6764 1694-1698 IN denotes that
T6765 1712-1714 VBZ denotes is
T6766 1699-1700 DT denotes a
T6767 1707-1711 NN denotes tail
T6768 1701-1703 CD denotes 40
T6769 1704-1706 NN denotes nt
T6770 1715-1725 JJ denotes sufficient
T6771 1726-1729 IN denotes for
T6772 1730-1740 NN denotes activation
T6773 1741-1742 -LRB- denotes (
T6774 1742-1744 CD denotes 13
T6775 1744-1745 -RRB- denotes )
T6776 1745-1746 . denotes .
T6777 1746-1908 sentence denotes However, the efficiency of the displacement significantly decreased as the thymine content of the 3′-tail dropped to 33%, as in TAA17 or TCC17 (Figure 6B and C).
T6778 1747-1754 RB denotes However
T6779 1805-1814 VBD denotes decreased
T6780 1754-1756 , denotes ,
T6781 1756-1759 DT denotes the
T6782 1760-1770 NN denotes efficiency
T6783 1771-1773 IN denotes of
T6784 1774-1777 DT denotes the
T6785 1778-1790 NN denotes displacement
T6786 1791-1804 RB denotes significantly
T6787 1815-1817 IN denotes as
T6788 1853-1860 VBD denotes dropped
T6789 1818-1821 DT denotes the
T6790 1830-1837 NN denotes content
T6791 1822-1829 NN denotes thymine
T6792 1838-1840 IN denotes of
T6793 1841-1844 DT denotes the
T6794 1848-1852 NN denotes tail
T6795 1845-1846 CD denotes 3
T6796 1846-1847 SYM denotes ′
T6797 1847-1848 HYPH denotes -
T6798 1861-1863 IN denotes to
T6799 1864-1866 CD denotes 33
T6800 1866-1867 NN denotes %
T6801 1867-1869 , denotes ,
T6802 1869-1871 IN denotes as
T6803 1872-1874 IN denotes in
T6804 1875-1880 NN denotes TAA17
T6805 1881-1883 CC denotes or
T6806 1884-1889 NN denotes TCC17
T6807 1890-1891 -LRB- denotes (
T6808 1898-1900 NN denotes 6B
T6809 1891-1897 NN denotes Figure
T6810 1901-1904 CC denotes and
T6811 1905-1906 NN denotes C
T6812 1906-1907 -RRB- denotes )
T6813 1907-1908 . denotes .
T6814 1908-2023 sentence denotes Thus, the minimal thymine content required for activation of the Mcm helicase may be somewhere between 33 and 50%.
T6815 1909-1913 RB denotes Thus
T6816 1991-1993 VB denotes be
T6817 1913-1915 , denotes ,
T6818 1915-1918 DT denotes the
T6819 1935-1942 NN denotes content
T6820 1919-1926 JJ denotes minimal
T6821 1927-1934 NN denotes thymine
T6822 1943-1951 VBN denotes required
T6823 1952-1955 IN denotes for
T6824 1956-1966 NN denotes activation
T6825 1967-1969 IN denotes of
T6826 1970-1973 DT denotes the
T6827 1978-1986 NN denotes helicase
T6828 1974-1977 NN denotes Mcm
T6829 1987-1990 MD denotes may
T6830 1994-2003 RB denotes somewhere
T6831 2004-2011 IN denotes between
T6832 2012-2014 CD denotes 33
T6833 2021-2022 NN denotes %
T6834 2015-2018 CC denotes and
T6835 2019-2021 CD denotes 50
T6836 2022-2023 . denotes .
R4301 T6404 T6405 det The,effects
R4302 T6406 T6405 prep of,effects
R4303 T6407 T6408 det the,content
R4304 T6408 T6406 pobj content,of
R4305 T6409 T6408 compound thymine,content
R4306 T6410 T6408 prep of,content
R4307 T6411 T6412 det the,tail
R4308 T6412 T6410 pobj tail,of
R4309 T6413 T6412 nummod 3,tail
R4310 T6414 T6413 punct ′,3
R4311 T6415 T6412 punct -,tail
R4312 T6416 T6405 prep on,effects
R4313 T6417 T6418 compound Mcm,helicase
R4314 T6418 T6419 compound helicase,activity
R4315 T6419 T6416 pobj activity,on
R4316 T6421 T6422 nsubj We,examined
R4317 T6423 T6422 advmod next,examined
R4318 T6424 T6425 advmod more,systematically
R4319 T6425 T6422 advmod systematically,examined
R4320 T6426 T6427 det the,effect
R4321 T6427 T6422 dobj effect,examined
R4322 T6428 T6427 prep of,effect
R4323 T6429 T6430 det the,compositions
R4324 T6430 T6428 pobj compositions,of
R4325 T6431 T6430 prep of,compositions
R4326 T6432 T6433 det the,residues
R4327 T6433 T6431 pobj residues,of
R4328 T6434 T6433 compound thymine,residues
R4329 T6435 T6433 prep of,residues
R4330 T6436 T6437 det the,tail
R4331 T6437 T6435 pobj tail,of
R4332 T6438 T6437 nummod 3,tail
R4333 T6439 T6438 punct ′,3
R4334 T6440 T6437 punct -,tail
R4335 T6441 T6427 prep on,effect
R4336 T6442 T6443 det the,activity
R4337 T6443 T6441 pobj activity,on
R4338 T6444 T6445 compound Mcm,helicase
R4339 T6445 T6443 compound helicase,activity
R4340 T6446 T6422 punct .,examined
R4341 T6448 T6449 det A,DNA
R4342 T6449 T6456 nsubjpass DNA,constructed
R4343 T6450 T6449 amod partial,DNA
R4344 T6451 T6449 nmod heteroduplex,DNA
R4345 T6452 T6449 nmod M13,DNA
R4346 T6453 T6454 amod single,stranded
R4347 T6454 T6449 amod stranded,DNA
R4348 T6455 T6454 punct -,stranded
R4349 T6457 T6449 acl containing,DNA
R4350 T6458 T6459 det a,region
R4351 T6459 T6457 dobj region,containing
R4352 T6460 T6461 nummod 37,bp
R4353 T6461 T6459 compound bp,region
R4354 T6462 T6459 compound duplex,region
R4355 T6463 T6457 prep in,containing
R4356 T6464 T6465 det the,presence
R4357 T6465 T6463 pobj presence,in
R4358 T6466 T6465 cc or,presence
R4359 T6467 T6465 conj absence,presence
R4360 T6468 T6465 prep of,presence
R4361 T6469 T6470 det the,tail
R4362 T6470 T6468 pobj tail,of
R4363 T6471 T6472 nummod 50,nt
R4364 T6472 T6473 npadvmod nt,long
R4365 T6473 T6470 amod long,tail
R4366 T6474 T6470 nummod 3,tail
R4367 T6475 T6474 punct ′,3
R4368 T6476 T6470 punct -,tail
R4369 T6477 T6470 prep of,tail
R4370 T6478 T6479 amod various,compositions
R4371 T6479 T6477 pobj compositions,of
R4372 T6480 T6479 compound nucleotide,compositions
R4373 T6481 T6456 auxpass were,constructed
R4374 T6482 T6456 cc and,constructed
R4375 T6483 T6484 det the,unwinding
R4376 T6484 T6485 nsubjpass unwinding,examined
R4377 T6485 T6456 conj examined,constructed
R4378 T6486 T6484 prep by,unwinding
R4379 T6487 T6488 compound mouse,Mcm4
R4380 T6488 T6486 pobj Mcm4,by
R4381 T6489 T6488 punct /,Mcm4
R4382 T6490 T6488 nummod 6,Mcm4
R4383 T6491 T6488 punct /,Mcm4
R4384 T6492 T6488 nummod 7,Mcm4
R4385 T6493 T6485 auxpass was,examined
R4386 T6494 T6495 punct (,6A
R4387 T6495 T6485 parataxis 6A,examined
R4388 T6496 T6495 compound Figure,6A
R4389 T6497 T6495 punct ),6A
R4390 T6498 T6485 punct .,examined
R4391 T6500 T6501 prep Due,displaced
R4392 T6502 T6500 pcomp to,Due
R4393 T6503 T6504 poss its,processivity
R4394 T6504 T6500 pobj processivity,Due
R4395 T6505 T6504 amod low,processivity
R4396 T6506 T6501 punct ", ",displaced
R4397 T6507 T6501 nsubj Mcm4,displaced
R4398 T6508 T6507 punct /,Mcm4
R4399 T6509 T6507 nummod 6,Mcm4
R4400 T6510 T6507 punct /,Mcm4
R4401 T6511 T6507 nummod 7,Mcm4
R4402 T6512 T6501 advmod barely,displaced
R4403 T6513 T6514 det the,oligonucleotide
R4404 T6514 T6501 dobj oligonucleotide,displaced
R4405 T6515 T6514 amod annealed,oligonucleotide
R4406 T6516 T6514 compound 37mer,oligonucleotide
R4407 T6517 T6514 prep without,oligonucleotide
R4408 T6518 T6519 det a,tail
R4409 T6519 T6517 pobj tail,without
R4410 T6520 T6519 nummod 3,tail
R4411 T6521 T6520 punct ′,3
R4412 T6522 T6519 punct -,tail
R4413 T6523 T6524 punct (,6A
R4414 T6524 T6514 parataxis 6A,oligonucleotide
R4415 T6525 T6524 dep 37mer,6A
R4416 T6526 T6524 punct ;,6A
R4417 T6527 T6524 compound Figure,6A
R4418 T6528 T6524 punct ),6A
R4419 T6529 T6501 punct .,displaced
R4420 T6531 T6532 advmod Only,activity
R4421 T6532 T6535 nsubjpass activity,observed
R4422 T6533 T6532 amod weak,activity
R4423 T6534 T6532 compound helicase,activity
R4424 T6536 T6535 auxpass was,observed
R4425 T6537 T6535 prep on,observed
R4426 T6538 T6539 det the,substrate
R4427 T6539 T6537 pobj substrate,on
R4428 T6540 T6539 acl carrying,substrate
R4429 T6541 T6542 det the,tail
R4430 T6542 T6540 dobj tail,carrying
R4431 T6543 T6542 nummod 3,tail
R4432 T6544 T6543 punct ′,3
R4433 T6545 T6542 punct -,tail
R4434 T6546 T6542 prep of,tail
R4435 T6547 T6548 nummod 25,repeats
R4436 T6548 T6546 pobj repeats,of
R4437 T6549 T6548 prep of,repeats
R4438 T6550 T6551 compound TA,dinucleotide
R4439 T6551 T6549 pobj dinucleotide,of
R4440 T6552 T6553 punct (,6A
R4441 T6553 T6540 parataxis 6A,carrying
R4442 T6554 T6555 nummod 37,TA25
R4443 T6555 T6553 dep TA25,6A
R4444 T6556 T6555 punct -,TA25
R4445 T6557 T6553 punct ;,6A
R4446 T6558 T6553 compound Figure,6A
R4447 T6559 T6553 punct ),6A
R4448 T6560 T6535 punct ", ",observed
R4449 T6561 T6562 mark whereas,observed
R4450 T6562 T6535 advcl observed,observed
R4451 T6563 T6564 amod strong,activity
R4452 T6564 T6562 nsubjpass activity,observed
R4453 T6565 T6564 compound helicase,activity
R4454 T6566 T6562 auxpass was,observed
R4455 T6567 T6562 prep on,observed
R4456 T6568 T6569 nummod 37,TTA17
R4457 T6569 T6567 pobj TTA17,on
R4458 T6570 T6569 punct -,TTA17
R4459 T6571 T6535 punct .,observed
R4460 T6573 T6574 nsubj Increase,increase
R4461 T6575 T6573 prep of,Increase
R4462 T6576 T6577 compound thymine,content
R4463 T6577 T6575 pobj content,of
R4464 T6578 T6573 prep on,Increase
R4465 T6579 T6580 det the,tail
R4466 T6580 T6578 pobj tail,on
R4467 T6581 T6580 nummod 3,tail
R4468 T6582 T6581 punct ′,3
R4469 T6583 T6580 punct -,tail
R4470 T6584 T6574 aux did,increase
R4471 T6585 T6574 neg not,increase
R4472 T6586 T6574 advmod further,increase
R4473 T6587 T6588 det the,extent
R4474 T6588 T6574 dobj extent,increase
R4475 T6589 T6588 prep of,extent
R4476 T6590 T6589 pobj unwinding,of
R4477 T6591 T6592 punct (,6A
R4478 T6592 T6590 parataxis 6A,unwinding
R4479 T6593 T6594 nummod 37,TTTA13
R4480 T6594 T6592 dep TTTA13,6A
R4481 T6595 T6594 punct -,TTTA13
R4482 T6596 T6594 punct ", ",TTTA13
R4483 T6597 T6598 nummod 37,TTTTA10
R4484 T6598 T6594 conj TTTTA10,TTTA13
R4485 T6599 T6598 punct -,TTTTA10
R4486 T6600 T6598 cc and,TTTTA10
R4487 T6601 T6602 nummod 37,T50
R4488 T6602 T6598 conj T50,TTTTA10
R4489 T6603 T6602 punct -,T50
R4490 T6604 T6592 punct ;,6A
R4491 T6605 T6592 compound Figure,6A
R4492 T6606 T6592 punct ),6A
R4493 T6607 T6574 punct ", ",increase
R4494 T6608 T6574 advcl suggesting,increase
R4495 T6609 T6610 mark that,be
R4496 T6610 T6608 ccomp be,suggesting
R4497 T6611 T6612 nummod 17,repeats
R4498 T6612 T6610 nsubj repeats,be
R4499 T6613 T6612 prep of,repeats
R4500 T6614 T6615 compound TT,dinucleotides
R4501 T6615 T6613 pobj dinucleotides,of
R4502 T6616 T6617 punct (,thymine
R4503 T6617 T6615 parataxis thymine,dinucleotides
R4504 T6618 T6619 nummod 67,%
R4505 T6619 T6617 compound %,thymine
R4506 T6620 T6617 punct ),thymine
R4507 T6621 T6610 aux may,be
R4508 T6622 T6610 acomp sufficient,be
R4509 T6623 T6622 prep for,sufficient
R4510 T6624 T6623 pobj activation,for
R4511 T6625 T6624 prep of,activation
R4512 T6626 T6627 compound Mcm,helicase
R4513 T6627 T6625 pobj helicase,of
R4514 T6628 T6574 punct .,increase
R4515 T6630 T6631 nsubjpass It,noted
R4516 T6632 T6631 aux should,noted
R4517 T6633 T6631 auxpass be,noted
R4518 T6634 T6635 mark that,anneal
R4519 T6635 T6631 ccomp anneal,noted
R4520 T6636 T6637 det the,tail
R4521 T6637 T6635 nsubj tail,anneal
R4522 T6638 T6637 compound TA25,tail
R4523 T6639 T6635 aux would,anneal
R4524 T6640 T6635 dep self,anneal
R4525 T6641 T6635 punct -,anneal
R4526 T6642 T6635 cc and,anneal
R4527 T6643 T6644 nsubj this,prevent
R4528 T6644 T6635 conj prevent,anneal
R4529 T6645 T6644 aux would,prevent
R4530 T6646 T6647 det the,loading
R4531 T6647 T6644 dobj loading,prevent
R4532 T6648 T6647 prep of,loading
R4533 T6649 T6648 pobj Mcm,of
R4534 T6650 T6631 punct ", ",noted
R4535 T6651 T6652 mark since,enhance
R4536 T6652 T6631 advcl enhance,noted
R4537 T6653 T6654 det the,tail
R4538 T6654 T6652 nsubj tail,enhance
R4539 T6655 T6654 nummod 3,tail
R4540 T6656 T6655 punct ′,3
R4541 T6657 T6654 punct -,tail
R4542 T6658 T6654 acl containing,tail
R4543 T6659 T6658 dobj TTAA13,containing
R4544 T6660 T6659 cc or,TTAA13
R4545 T6661 T6659 conj TTTAAA8,TTAA13
R4546 T6662 T6652 aux did,enhance
R4547 T6663 T6652 neg not,enhance
R4548 T6664 T6665 det the,unwinding
R4549 T6665 T6652 dobj unwinding,enhance
R4550 T6666 T6652 advmod either,enhance
R4551 T6667 T6668 punct (,shown
R4552 T6668 T6652 parataxis shown,enhance
R4553 T6669 T6668 nsubj data,shown
R4554 T6670 T6668 neg not,shown
R4555 T6671 T6668 punct ),shown
R4556 T6672 T6631 punct .,noted
R4557 T6674 T6675 advmod Therefore,examined
R4558 T6676 T6675 punct ", ",examined
R4559 T6677 T6675 nsubj we,examined
R4560 T6678 T6675 advmod next,examined
R4561 T6679 T6680 det the,effects
R4562 T6680 T6675 dobj effects,examined
R4563 T6681 T6680 prep of,effects
R4564 T6682 T6683 amod repeating,sequences
R4565 T6683 T6681 pobj sequences,of
R4566 T6684 T6683 prep of,sequences
R4567 T6685 T6684 pobj thymine,of
R4568 T6686 T6685 cc and,thymine
R4569 T6687 T6685 conj cytosine,thymine
R4570 T6688 T6689 punct (,6B
R4571 T6689 T6675 parataxis 6B,examined
R4572 T6690 T6689 compound Figure,6B
R4573 T6691 T6689 punct ),6B
R4574 T6692 T6675 punct .,examined
R4575 T6694 T6695 amod Partial,substrates
R4576 T6695 T6697 nsubjpass substrates,displaced
R4577 T6696 T6695 compound heteroduplex,substrates
R4578 T6698 T6695 acl containing,substrates
R4579 T6699 T6700 det the,tail
R4580 T6700 T6698 dobj tail,containing
R4581 T6701 T6700 nummod 3,tail
R4582 T6702 T6701 punct ′,3
R4583 T6703 T6700 punct -,tail
R4584 T6704 T6700 prep of,tail
R4585 T6705 T6706 nmod TC25,TTCC17
R4586 T6706 T6704 pobj TTCC17,of
R4587 T6707 T6706 punct ", ",TTCC17
R4588 T6708 T6706 nmod TTCC13,TTCC17
R4589 T6709 T6706 punct ", ",TTCC17
R4590 T6710 T6706 nmod TTTCCC8,TTCC17
R4591 T6711 T6706 punct ", ",TTCC17
R4592 T6712 T6706 nmod TTTTCCCC6,TTCC17
R4593 T6713 T6706 punct ", ",TTCC17
R4594 T6714 T6697 auxpass were,displaced
R4595 T6715 T6697 agent by,displaced
R4596 T6716 T6717 det the,complex
R4597 T6717 T6715 pobj complex,by
R4598 T6718 T6717 nmod Mcm4,complex
R4599 T6719 T6718 punct /,Mcm4
R4600 T6720 T6718 nummod 6,Mcm4
R4601 T6721 T6718 punct /,Mcm4
R4602 T6722 T6718 nummod 7,Mcm4
R4603 T6723 T6697 prep to,displaced
R4604 T6724 T6725 det the,extent
R4605 T6725 T6723 pobj extent,to
R4606 T6726 T6725 amod similar,extent
R4607 T6727 T6726 prep to,similar
R4608 T6728 T6727 pobj that,to
R4609 T6729 T6728 acl achieved,that
R4610 T6730 T6729 agent by,achieved
R4611 T6731 T6730 pobj TTA17,by
R4612 T6732 T6697 punct ", ",displaced
R4613 T6733 T6697 advcl suggesting,displaced
R4614 T6734 T6735 mark that,is
R4615 T6735 T6733 ccomp is,suggesting
R4616 T6736 T6737 nummod 50,%
R4617 T6737 T6738 compound %,content
R4618 T6738 T6735 nsubj content,is
R4619 T6739 T6738 compound thymine,content
R4620 T6740 T6735 acomp sufficient,is
R4621 T6741 T6740 prep for,sufficient
R4622 T6742 T6743 amod full,activation
R4623 T6743 T6741 pobj activation,for
R4624 T6744 T6743 prep of,activation
R4625 T6745 T6746 compound Mcm,helicase
R4626 T6746 T6744 pobj helicase,of
R4627 T6747 T6697 punct .,displaced
R4628 T6749 T6750 nsubjpass TTCC13,displaced
R4629 T6751 T6749 cc and,TTCC13
R4630 T6752 T6749 conj TTCC17,TTCC13
R4631 T6753 T6750 auxpass were,displaced
R4632 T6754 T6750 prep to,displaced
R4633 T6755 T6756 det a,extent
R4634 T6756 T6754 pobj extent,to
R4635 T6757 T6756 amod similar,extent
R4636 T6758 T6750 punct ", ",displaced
R4637 T6759 T6750 advcl consistent,displaced
R4638 T6760 T6759 prep with,consistent
R4639 T6761 T6762 det the,result
R4640 T6762 T6760 pobj result,with
R4641 T6763 T6762 amod earlier,result
R4642 T6764 T6765 mark that,is
R4643 T6765 T6762 acl is,result
R4644 T6766 T6767 det a,tail
R4645 T6767 T6765 nsubj tail,is
R4646 T6768 T6769 nummod 40,nt
R4647 T6769 T6767 compound nt,tail
R4648 T6770 T6765 acomp sufficient,is
R4649 T6771 T6770 prep for,sufficient
R4650 T6772 T6771 pobj activation,for
R4651 T6773 T6774 punct (,13
R4652 T6774 T6765 parataxis 13,is
R4653 T6775 T6774 punct ),13
R4654 T6776 T6750 punct .,displaced
R4655 T6778 T6779 advmod However,decreased
R4656 T6780 T6779 punct ", ",decreased
R4657 T6781 T6782 det the,efficiency
R4658 T6782 T6779 nsubj efficiency,decreased
R4659 T6783 T6782 prep of,efficiency
R4660 T6784 T6785 det the,displacement
R4661 T6785 T6783 pobj displacement,of
R4662 T6786 T6779 advmod significantly,decreased
R4663 T6787 T6788 mark as,dropped
R4664 T6788 T6779 advcl dropped,decreased
R4665 T6789 T6790 det the,content
R4666 T6790 T6788 nsubj content,dropped
R4667 T6791 T6790 compound thymine,content
R4668 T6792 T6790 prep of,content
R4669 T6793 T6794 det the,tail
R4670 T6794 T6792 pobj tail,of
R4671 T6795 T6794 nummod 3,tail
R4672 T6796 T6795 punct ′,3
R4673 T6797 T6794 punct -,tail
R4674 T6798 T6788 prep to,dropped
R4675 T6799 T6800 nummod 33,%
R4676 T6800 T6798 pobj %,to
R4677 T6801 T6788 punct ", ",dropped
R4678 T6802 T6788 prep as,dropped
R4679 T6803 T6802 prep in,as
R4680 T6804 T6803 pobj TAA17,in
R4681 T6805 T6804 cc or,TAA17
R4682 T6806 T6804 conj TCC17,TAA17
R4683 T6807 T6808 punct (,6B
R4684 T6808 T6788 parataxis 6B,dropped
R4685 T6809 T6808 compound Figure,6B
R4686 T6810 T6808 cc and,6B
R4687 T6811 T6808 conj C,6B
R4688 T6812 T6808 punct ),6B
R4689 T6813 T6779 punct .,decreased
R4690 T6815 T6816 advmod Thus,be
R4691 T6817 T6816 punct ", ",be
R4692 T6818 T6819 det the,content
R4693 T6819 T6816 nsubj content,be
R4694 T6820 T6819 amod minimal,content
R4695 T6821 T6819 compound thymine,content
R4696 T6822 T6819 acl required,content
R4697 T6823 T6822 prep for,required
R4698 T6824 T6823 pobj activation,for
R4699 T6825 T6824 prep of,activation
R4700 T6826 T6827 det the,helicase
R4701 T6827 T6825 pobj helicase,of
R4702 T6828 T6827 compound Mcm,helicase
R4703 T6829 T6816 aux may,be
R4704 T6830 T6816 advmod somewhere,be
R4705 T6831 T6830 prep between,somewhere
R4706 T6832 T6833 nummod 33,%
R4707 T6833 T6831 pobj %,between
R4708 T6834 T6832 cc and,33
R4709 T6835 T6832 conj 50,33
R4710 T6836 T6816 punct .,be

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T6357 19-26 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T6358 53-56 GO:0042555 denotes Mcm
T6359 57-65 GO_EXT:0004386 denotes helicase
T6360 150-157 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T6361 158-166 CHEBI_EXT:residue denotes residues
T6362 189-192 GO:0042555 denotes Mcm
T6363 193-201 GO_EXT:0004386 denotes helicase
T6364 228-234 SO:0000985 denotes duplex
T6365 239-258 CHEBI_SO_EXT:single_stranded_DNA denotes single-stranded DNA
T6366 275-277 SO_EXT:0000028 denotes bp
T6367 278-284 SO:0000985 denotes duplex
T6368 329-331 CHEBI_SO_EXT:nucleotide denotes nt
T6369 356-366 CHEBI_SO_EXT:nucleotide denotes nucleotide
T6370 418-423 NCBITaxon:10088 denotes mouse
T6371 424-428 PR_EXT:000010246 denotes Mcm4
T6372 424-432 GO:0097373 denotes Mcm4/6/7
T6373 488-492 PR_EXT:000010246 denotes Mcm4
T6374 488-496 GO:0097373 denotes Mcm4/6/7
T6375 518-526 GO:0097617 denotes annealed
T6376 533-548 CHEBI_SO_EXT:oligonucleotide denotes oligonucleotide
T6377 597-605 GO_EXT:0004386 denotes helicase
T6378 672-679 SO_EXT:sequence_repeat_unit_or_region denotes repeats
T6379 686-698 CHEBI_SO_EXT:dinucleotide denotes dinucleotide
T6380 736-744 GO_EXT:0004386 denotes helicase
T6381 792-799 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T6382 938-945 SO_EXT:sequence_repeat_unit_or_region denotes repeats
T6383 952-965 CHEBI_SO_EXT:dinucleotide denotes dinucleotides
T6384 971-978 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T6385 1016-1019 GO:0042555 denotes Mcm
T6386 1020-1028 GO_EXT:0004386 denotes helicase
T6387 1079-1085 GO:0097617 denotes anneal
T6388 1124-1127 GO:0042555 denotes Mcm
T6389 1274-1283 SO_EXT:sequence_repeat_unit_or_region denotes repeating
T6390 1284-1293 SO_EXT:biological_sequence denotes sequences
T6391 1297-1304 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T6392 1309-1317 CHEBI_EXT:cytosine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes cytosine
T6393 1345-1351 SO:0000985 denotes duplex
T6394 1452-1456 PR_EXT:000010246 denotes Mcm4
T6395 1452-1468 GO:0097373 denotes Mcm4/6/7 complex
T6396 1538-1545 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T6397 1591-1594 GO:0042555 denotes Mcm
T6398 1595-1603 GO_EXT:0004386 denotes helicase
T6399 1704-1706 CHEBI_SO_EXT:nucleotide denotes nt
T6400 1822-1829 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T6401 1927-1934 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T6402 1974-1977 GO:0042555 denotes Mcm
T6403 1978-1986 GO_EXT:0004386 denotes helicase

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T6337 53-56 GO:0042555 denotes Mcm
T6338 189-192 GO:0042555 denotes Mcm
T6339 228-234 SO:0000985 denotes duplex
T6340 239-254 SO:0000984 denotes single-stranded
T6341 275-277 SO:0000028 denotes bp
T6342 278-284 SO:0000985 denotes duplex
T6343 418-423 NCBITaxon:10088 denotes mouse
T6344 424-428 PR:000010246 denotes Mcm4
T6345 424-432 GO:0097373 denotes Mcm4/6/7
T6346 488-492 PR:000010246 denotes Mcm4
T6347 488-496 GO:0097373 denotes Mcm4/6/7
T6348 518-526 GO:0097617 denotes annealed
T6349 1016-1019 GO:0042555 denotes Mcm
T6350 1079-1085 GO:0097617 denotes anneal
T6351 1124-1127 GO:0042555 denotes Mcm
T6352 1345-1351 SO:0000985 denotes duplex
T6353 1452-1456 PR:000010246 denotes Mcm4
T6354 1452-1468 GO:0097373 denotes Mcm4/6/7 complex
T6355 1591-1594 GO:0042555 denotes Mcm
T6356 1974-1977 GO:0042555 denotes Mcm

2_test

Id Subject Object Predicate Lexical cue
15917436-14609960-76775522 1742-1744 14609960 denotes 13