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PMC:1140370 / 15927-17346
Annnotations
craft-sa-dev
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4762 | 0-9 | JJ | denotes | Symmetric |
T4763 | 10-17 | NN | denotes | binding |
T4764 | 59-67 | VBZ | denotes | suggests |
T4765 | 18-20 | IN | denotes | of |
T4766 | 21-24 | DT | denotes | the |
T4767 | 41-48 | NN | denotes | hexamer |
T4768 | 25-29 | NN | denotes | Mcm4 |
T4769 | 29-30 | HYPH | denotes | / |
T4770 | 30-31 | CD | denotes | 6 |
T4771 | 31-32 | HYPH | denotes | / |
T4772 | 32-33 | CD | denotes | 7 |
T4773 | 34-40 | JJ | denotes | double |
T4774 | 49-51 | IN | denotes | to |
T4775 | 52-58 | NN | denotes | bubble |
T4776 | 68-72 | IN | denotes | that |
T4777 | 86-95 | VBZ | denotes | catalyzes |
T4778 | 73-77 | DT | denotes | each |
T4779 | 78-85 | NN | denotes | hexamer |
T4780 | 96-105 | NN | denotes | unwinding |
T4781 | 106-108 | IN | denotes | of |
T4782 | 109-112 | CD | denotes | one |
T4783 | 113-115 | IN | denotes | of |
T4784 | 116-119 | DT | denotes | the |
T4785 | 131-139 | NNS | denotes | segments |
T4786 | 120-123 | CD | denotes | two |
T4787 | 124-130 | NN | denotes | duplex |
T4788 | 139-140 | . | denotes | . |
T4789 | 140-236 | sentence | denotes | We asked whether activation of both hexamers is required for unwinding of the bubble substrate. |
T4790 | 141-143 | PRP | denotes | We |
T4791 | 144-149 | VBD | denotes | asked |
T4792 | 150-157 | IN | denotes | whether |
T4793 | 189-197 | VBN | denotes | required |
T4794 | 158-168 | NN | denotes | activation |
T4795 | 169-171 | IN | denotes | of |
T4796 | 172-176 | DT | denotes | both |
T4797 | 177-185 | NNS | denotes | hexamers |
T4798 | 186-188 | VBZ | denotes | is |
T4799 | 198-201 | IN | denotes | for |
T4800 | 202-211 | NN | denotes | unwinding |
T4801 | 212-214 | IN | denotes | of |
T4802 | 215-218 | DT | denotes | the |
T4803 | 226-235 | NN | denotes | substrate |
T4804 | 219-225 | NN | denotes | bubble |
T4805 | 235-236 | . | denotes | . |
T4806 | 236-383 | sentence | denotes | The preferred bubble substrate which is efficiently unwound by Mcm4/6/7 contains thymine stretches on both strands of the single-stranded segment. |
T4807 | 237-240 | DT | denotes | The |
T4808 | 258-267 | NN | denotes | substrate |
T4809 | 241-250 | JJ | denotes | preferred |
T4810 | 251-257 | NN | denotes | bubble |
T4811 | 309-317 | VBZ | denotes | contains |
T4812 | 268-273 | WDT | denotes | which |
T4813 | 289-296 | VBN | denotes | unwound |
T4814 | 274-276 | VBZ | denotes | is |
T4815 | 277-288 | RB | denotes | efficiently |
T4816 | 297-299 | IN | denotes | by |
T4817 | 300-304 | NN | denotes | Mcm4 |
T4818 | 304-305 | HYPH | denotes | / |
T4819 | 305-306 | CD | denotes | 6 |
T4820 | 306-307 | HYPH | denotes | / |
T4821 | 307-308 | CD | denotes | 7 |
T4822 | 318-325 | NN | denotes | thymine |
T4823 | 326-335 | NNS | denotes | stretches |
T4824 | 336-338 | IN | denotes | on |
T4825 | 339-343 | DT | denotes | both |
T4826 | 344-351 | NNS | denotes | strands |
T4827 | 352-354 | IN | denotes | of |
T4828 | 355-358 | DT | denotes | the |
T4829 | 375-382 | NN | denotes | segment |
T4830 | 359-365 | JJ | denotes | single |
T4831 | 366-374 | VBN | denotes | stranded |
T4832 | 365-366 | HYPH | denotes | - |
T4833 | 382-383 | . | denotes | . |
T4834 | 383-615 | sentence | denotes | We constructed a hetero-bubble (Bub66/T–G-rich) in which one strand is T-rich (same as Bub66/T-rich) and the other strand is G-rich (same as Bub66/G-rich) (13), and helicase assays were conducted with increasing amount of Mcm4/6/7. |
T4835 | 384-386 | PRP | denotes | We |
T4836 | 387-398 | VBD | denotes | constructed |
T4837 | 399-400 | DT | denotes | a |
T4838 | 401-414 | JJ | denotes | hetero-bubble |
T4839 | 415-416 | -LRB- | denotes | ( |
T4840 | 416-421 | NN | denotes | Bub66 |
T4841 | 424-425 | NN | denotes | G |
T4842 | 421-422 | HYPH | denotes | / |
T4843 | 422-423 | NN | denotes | T |
T4844 | 423-424 | HYPH | denotes | – |
T4845 | 425-426 | HYPH | denotes | - |
T4846 | 426-430 | JJ | denotes | rich |
T4847 | 430-431 | -RRB- | denotes | ) |
T4848 | 432-434 | IN | denotes | in |
T4849 | 452-454 | VBZ | denotes | is |
T4850 | 435-440 | WDT | denotes | which |
T4851 | 441-444 | CD | denotes | one |
T4852 | 445-451 | NN | denotes | strand |
T4853 | 455-456 | NN | denotes | T |
T4854 | 457-461 | JJ | denotes | rich |
T4855 | 456-457 | HYPH | denotes | - |
T4856 | 462-463 | -LRB- | denotes | ( |
T4857 | 463-467 | JJ | denotes | same |
T4858 | 468-470 | IN | denotes | as |
T4859 | 471-476 | NN | denotes | Bub66 |
T4860 | 477-478 | NN | denotes | T |
T4861 | 476-477 | HYPH | denotes | / |
T4862 | 478-479 | HYPH | denotes | - |
T4863 | 479-483 | JJ | denotes | rich |
T4864 | 483-484 | -RRB- | denotes | ) |
T4865 | 485-488 | CC | denotes | and |
T4866 | 489-492 | DT | denotes | the |
T4867 | 499-505 | NN | denotes | strand |
T4868 | 493-498 | JJ | denotes | other |
T4869 | 506-508 | VBZ | denotes | is |
T4870 | 509-510 | NN | denotes | G |
T4871 | 511-515 | JJ | denotes | rich |
T4872 | 510-511 | HYPH | denotes | - |
T4873 | 516-517 | -LRB- | denotes | ( |
T4874 | 517-521 | JJ | denotes | same |
T4875 | 522-524 | IN | denotes | as |
T4876 | 525-530 | NN | denotes | Bub66 |
T4877 | 531-532 | NN | denotes | G |
T4878 | 530-531 | HYPH | denotes | / |
T4879 | 532-533 | HYPH | denotes | - |
T4880 | 533-537 | JJ | denotes | rich |
T4881 | 537-538 | -RRB- | denotes | ) |
T4882 | 539-540 | -LRB- | denotes | ( |
T4883 | 540-542 | CD | denotes | 13 |
T4884 | 542-543 | -RRB- | denotes | ) |
T4885 | 543-545 | , | denotes | , |
T4886 | 545-548 | CC | denotes | and |
T4887 | 549-557 | NN | denotes | helicase |
T4888 | 558-564 | NNS | denotes | assays |
T4889 | 570-579 | VBN | denotes | conducted |
T4890 | 565-569 | VBD | denotes | were |
T4891 | 580-584 | IN | denotes | with |
T4892 | 585-595 | VBG | denotes | increasing |
T4893 | 596-602 | NN | denotes | amount |
T4894 | 603-605 | IN | denotes | of |
T4895 | 606-610 | NN | denotes | Mcm4 |
T4896 | 610-611 | HYPH | denotes | / |
T4897 | 611-612 | CD | denotes | 6 |
T4898 | 612-613 | HYPH | denotes | / |
T4899 | 613-614 | CD | denotes | 7 |
T4900 | 614-615 | . | denotes | . |
T4901 | 615-704 | sentence | denotes | Only weak unwinding was detected on this substrate compared to Bub66/T-rich (Figure 3A). |
T4902 | 616-620 | RB | denotes | Only |
T4903 | 626-635 | NN | denotes | unwinding |
T4904 | 621-625 | JJ | denotes | weak |
T4905 | 640-648 | VBN | denotes | detected |
T4906 | 636-639 | VBD | denotes | was |
T4907 | 649-651 | IN | denotes | on |
T4908 | 652-656 | DT | denotes | this |
T4909 | 657-666 | NN | denotes | substrate |
T4910 | 667-675 | VBN | denotes | compared |
T4911 | 676-678 | IN | denotes | to |
T4912 | 679-684 | NN | denotes | Bub66 |
T4913 | 685-686 | NN | denotes | T |
T4914 | 684-685 | HYPH | denotes | / |
T4915 | 686-687 | HYPH | denotes | - |
T4916 | 687-691 | JJ | denotes | rich |
T4917 | 692-693 | -LRB- | denotes | ( |
T4918 | 700-702 | NN | denotes | 3A |
T4919 | 693-699 | NN | denotes | Figure |
T4920 | 702-703 | -RRB- | denotes | ) |
T4921 | 703-704 | . | denotes | . |
T4922 | 704-895 | sentence | denotes | Since Mcm4/6/7 can bind to Bub66/T–G-rich and forms a double hexameric complex (data not shown), the defective unwinding is not due to inefficient loading of the helicase onto the substrate. |
T4923 | 705-710 | IN | denotes | Since |
T4924 | 724-728 | VB | denotes | bind |
T4925 | 711-715 | NN | denotes | Mcm4 |
T4926 | 715-716 | HYPH | denotes | / |
T4927 | 716-717 | CD | denotes | 6 |
T4928 | 717-718 | HYPH | denotes | / |
T4929 | 718-719 | CD | denotes | 7 |
T4930 | 720-723 | MD | denotes | can |
T4931 | 826-828 | VBZ | denotes | is |
T4932 | 729-731 | IN | denotes | to |
T4933 | 732-737 | NN | denotes | Bub66 |
T4934 | 740-741 | NN | denotes | G |
T4935 | 737-738 | HYPH | denotes | / |
T4936 | 738-739 | NN | denotes | T |
T4937 | 739-740 | HYPH | denotes | – |
T4938 | 741-742 | HYPH | denotes | - |
T4939 | 742-746 | JJ | denotes | rich |
T4940 | 747-750 | CC | denotes | and |
T4941 | 751-756 | VBZ | denotes | forms |
T4942 | 757-758 | DT | denotes | a |
T4943 | 776-783 | NN | denotes | complex |
T4944 | 759-765 | JJ | denotes | double |
T4945 | 766-775 | JJ | denotes | hexameric |
T4946 | 784-785 | -LRB- | denotes | ( |
T4947 | 794-799 | VBN | denotes | shown |
T4948 | 785-789 | NNS | denotes | data |
T4949 | 790-793 | RB | denotes | not |
T4950 | 799-800 | -RRB- | denotes | ) |
T4951 | 800-802 | , | denotes | , |
T4952 | 802-805 | DT | denotes | the |
T4953 | 816-825 | NN | denotes | unwinding |
T4954 | 806-815 | JJ | denotes | defective |
T4955 | 829-832 | RB | denotes | not |
T4956 | 833-836 | IN | denotes | due |
T4957 | 837-839 | IN | denotes | to |
T4958 | 840-851 | JJ | denotes | inefficient |
T4959 | 852-859 | NN | denotes | loading |
T4960 | 860-862 | IN | denotes | of |
T4961 | 863-866 | DT | denotes | the |
T4962 | 867-875 | NN | denotes | helicase |
T4963 | 876-880 | IN | denotes | onto |
T4964 | 881-884 | DT | denotes | the |
T4965 | 885-894 | NN | denotes | substrate |
T4966 | 894-895 | . | denotes | . |
T4967 | 895-1193 | sentence | denotes | If one hexamer interacting with the thymine-rich strand dissociates from the other hexamer and displaces only one of the duplex segments, then it would result in generation of Y-fork structures which could not be further displaced due to the presence of G-rich 3′-tail and would appear on the gel. |
T4968 | 896-898 | IN | denotes | If |
T4969 | 952-963 | VBZ | denotes | dissociates |
T4970 | 899-902 | CD | denotes | one |
T4971 | 903-910 | NN | denotes | hexamer |
T4972 | 911-922 | VBG | denotes | interacting |
T4973 | 923-927 | IN | denotes | with |
T4974 | 928-931 | DT | denotes | the |
T4975 | 945-951 | NN | denotes | strand |
T4976 | 932-939 | NN | denotes | thymine |
T4977 | 940-944 | JJ | denotes | rich |
T4978 | 939-940 | HYPH | denotes | - |
T4979 | 1048-1054 | VB | denotes | result |
T4980 | 964-968 | IN | denotes | from |
T4981 | 969-972 | DT | denotes | the |
T4982 | 979-986 | NN | denotes | hexamer |
T4983 | 973-978 | JJ | denotes | other |
T4984 | 987-990 | CC | denotes | and |
T4985 | 991-1000 | VBZ | denotes | displaces |
T4986 | 1001-1005 | RB | denotes | only |
T4987 | 1006-1009 | CD | denotes | one |
T4988 | 1010-1012 | IN | denotes | of |
T4989 | 1013-1016 | DT | denotes | the |
T4990 | 1024-1032 | NNS | denotes | segments |
T4991 | 1017-1023 | NN | denotes | duplex |
T4992 | 1032-1034 | , | denotes | , |
T4993 | 1034-1038 | RB | denotes | then |
T4994 | 1039-1041 | PRP | denotes | it |
T4995 | 1042-1047 | MD | denotes | would |
T4996 | 1055-1057 | IN | denotes | in |
T4997 | 1058-1068 | NN | denotes | generation |
T4998 | 1069-1071 | IN | denotes | of |
T4999 | 1072-1073 | NN | denotes | Y |
T5000 | 1074-1078 | NN | denotes | fork |
T5001 | 1073-1074 | HYPH | denotes | - |
T5002 | 1079-1089 | NNS | denotes | structures |
T5003 | 1090-1095 | WDT | denotes | which |
T5004 | 1117-1126 | VBN | denotes | displaced |
T5005 | 1096-1101 | MD | denotes | could |
T5006 | 1102-1105 | RB | denotes | not |
T5007 | 1106-1108 | VB | denotes | be |
T5008 | 1109-1116 | RB | denotes | further |
T5009 | 1127-1130 | IN | denotes | due |
T5010 | 1131-1133 | IN | denotes | to |
T5011 | 1134-1137 | DT | denotes | the |
T5012 | 1138-1146 | NN | denotes | presence |
T5013 | 1147-1149 | IN | denotes | of |
T5014 | 1150-1151 | NN | denotes | G |
T5015 | 1152-1156 | JJ | denotes | rich |
T5016 | 1151-1152 | HYPH | denotes | - |
T5017 | 1160-1164 | NN | denotes | tail |
T5018 | 1157-1158 | CD | denotes | 3 |
T5019 | 1158-1159 | SYM | denotes | ′ |
T5020 | 1159-1160 | HYPH | denotes | - |
T5021 | 1165-1168 | CC | denotes | and |
T5022 | 1169-1174 | MD | denotes | would |
T5023 | 1175-1181 | VB | denotes | appear |
T5024 | 1182-1184 | IN | denotes | on |
T5025 | 1185-1188 | DT | denotes | the |
T5026 | 1189-1192 | NN | denotes | gel |
T5027 | 1192-1193 | . | denotes | . |
T5028 | 1193-1419 | sentence | denotes | However, we did not detect such intermediates during the course of the experiment (Figure 3B), suggesting that bubble can be displaced efficiently only when two molecules of the Mcm4/6/7 hexamers are simultaneously activated. |
T5029 | 1194-1201 | RB | denotes | However |
T5030 | 1214-1220 | VB | denotes | detect |
T5031 | 1201-1203 | , | denotes | , |
T5032 | 1203-1205 | PRP | denotes | we |
T5033 | 1206-1209 | VBD | denotes | did |
T5034 | 1210-1213 | RB | denotes | not |
T5035 | 1221-1225 | JJ | denotes | such |
T5036 | 1226-1239 | NNS | denotes | intermediates |
T5037 | 1240-1246 | IN | denotes | during |
T5038 | 1247-1250 | DT | denotes | the |
T5039 | 1251-1257 | NN | denotes | course |
T5040 | 1258-1260 | IN | denotes | of |
T5041 | 1261-1264 | DT | denotes | the |
T5042 | 1265-1275 | NN | denotes | experiment |
T5043 | 1276-1277 | -LRB- | denotes | ( |
T5044 | 1284-1286 | NN | denotes | 3B |
T5045 | 1277-1283 | NN | denotes | Figure |
T5046 | 1286-1287 | -RRB- | denotes | ) |
T5047 | 1287-1289 | , | denotes | , |
T5048 | 1289-1299 | VBG | denotes | suggesting |
T5049 | 1300-1304 | IN | denotes | that |
T5050 | 1319-1328 | VBN | denotes | displaced |
T5051 | 1305-1311 | NN | denotes | bubble |
T5052 | 1312-1315 | MD | denotes | can |
T5053 | 1316-1318 | VB | denotes | be |
T5054 | 1329-1340 | RB | denotes | efficiently |
T5055 | 1341-1345 | RB | denotes | only |
T5056 | 1409-1418 | VBN | denotes | activated |
T5057 | 1346-1350 | WRB | denotes | when |
T5058 | 1351-1354 | CD | denotes | two |
T5059 | 1355-1364 | NNS | denotes | molecules |
T5060 | 1365-1367 | IN | denotes | of |
T5061 | 1368-1371 | DT | denotes | the |
T5062 | 1381-1389 | NNS | denotes | hexamers |
T5063 | 1372-1376 | NN | denotes | Mcm4 |
T5064 | 1376-1377 | HYPH | denotes | / |
T5065 | 1377-1378 | CD | denotes | 6 |
T5066 | 1378-1379 | HYPH | denotes | / |
T5067 | 1379-1380 | CD | denotes | 7 |
T5068 | 1390-1393 | VBP | denotes | are |
T5069 | 1394-1408 | RB | denotes | simultaneously |
T5070 | 1418-1419 | . | denotes | . |
R3168 | T4762 | T4763 | amod | Symmetric,binding |
R3169 | T4763 | T4764 | nsubj | binding,suggests |
R3170 | T4765 | T4763 | prep | of,binding |
R3171 | T4766 | T4767 | det | the,hexamer |
R3172 | T4767 | T4765 | pobj | hexamer,of |
R3173 | T4768 | T4767 | nmod | Mcm4,hexamer |
R3174 | T4769 | T4768 | punct | /,Mcm4 |
R3175 | T4770 | T4768 | nummod | 6,Mcm4 |
R3176 | T4771 | T4768 | punct | /,Mcm4 |
R3177 | T4772 | T4768 | nummod | 7,Mcm4 |
R3178 | T4773 | T4767 | amod | double,hexamer |
R3179 | T4774 | T4763 | prep | to,binding |
R3180 | T4775 | T4774 | pobj | bubble,to |
R3181 | T4776 | T4777 | mark | that,catalyzes |
R3182 | T4777 | T4764 | ccomp | catalyzes,suggests |
R3183 | T4778 | T4779 | det | each,hexamer |
R3184 | T4779 | T4777 | nsubj | hexamer,catalyzes |
R3185 | T4780 | T4777 | dobj | unwinding,catalyzes |
R3186 | T4781 | T4780 | prep | of,unwinding |
R3187 | T4782 | T4781 | pobj | one,of |
R3188 | T4783 | T4782 | prep | of,one |
R3189 | T4784 | T4785 | det | the,segments |
R3190 | T4785 | T4783 | pobj | segments,of |
R3191 | T4786 | T4785 | nummod | two,segments |
R3192 | T4787 | T4785 | compound | duplex,segments |
R3193 | T4788 | T4764 | punct | .,suggests |
R3194 | T4790 | T4791 | nsubj | We,asked |
R3195 | T4792 | T4793 | mark | whether,required |
R3196 | T4793 | T4791 | ccomp | required,asked |
R3197 | T4794 | T4793 | nsubjpass | activation,required |
R3198 | T4795 | T4794 | prep | of,activation |
R3199 | T4796 | T4797 | det | both,hexamers |
R3200 | T4797 | T4795 | pobj | hexamers,of |
R3201 | T4798 | T4793 | auxpass | is,required |
R3202 | T4799 | T4793 | prep | for,required |
R3203 | T4800 | T4799 | pobj | unwinding,for |
R3204 | T4801 | T4800 | prep | of,unwinding |
R3205 | T4802 | T4803 | det | the,substrate |
R3206 | T4803 | T4801 | pobj | substrate,of |
R3207 | T4804 | T4803 | compound | bubble,substrate |
R3208 | T4805 | T4791 | punct | .,asked |
R3209 | T4807 | T4808 | det | The,substrate |
R3210 | T4808 | T4811 | nsubj | substrate,contains |
R3211 | T4809 | T4808 | amod | preferred,substrate |
R3212 | T4810 | T4808 | compound | bubble,substrate |
R3213 | T4812 | T4813 | dep | which,unwound |
R3214 | T4813 | T4808 | relcl | unwound,substrate |
R3215 | T4814 | T4813 | auxpass | is,unwound |
R3216 | T4815 | T4813 | advmod | efficiently,unwound |
R3217 | T4816 | T4813 | agent | by,unwound |
R3218 | T4817 | T4816 | pobj | Mcm4,by |
R3219 | T4818 | T4817 | punct | /,Mcm4 |
R3220 | T4819 | T4817 | nummod | 6,Mcm4 |
R3221 | T4820 | T4817 | punct | /,Mcm4 |
R3222 | T4821 | T4817 | nummod | 7,Mcm4 |
R3223 | T4822 | T4823 | compound | thymine,stretches |
R3224 | T4823 | T4811 | dobj | stretches,contains |
R3225 | T4824 | T4823 | prep | on,stretches |
R3226 | T4825 | T4826 | det | both,strands |
R3227 | T4826 | T4824 | pobj | strands,on |
R3228 | T4827 | T4826 | prep | of,strands |
R3229 | T4828 | T4829 | det | the,segment |
R3230 | T4829 | T4827 | pobj | segment,of |
R3231 | T4830 | T4831 | amod | single,stranded |
R3232 | T4831 | T4829 | amod | stranded,segment |
R3233 | T4832 | T4831 | punct | -,stranded |
R3234 | T4833 | T4811 | punct | .,contains |
R3235 | T4835 | T4836 | nsubj | We,constructed |
R3236 | T4837 | T4838 | det | a,hetero-bubble |
R3237 | T4838 | T4836 | dobj | hetero-bubble,constructed |
R3238 | T4839 | T4838 | punct | (,hetero-bubble |
R3239 | T4840 | T4841 | compound | Bub66,G |
R3240 | T4841 | T4838 | appos | G,hetero-bubble |
R3241 | T4842 | T4841 | punct | /,G |
R3242 | T4843 | T4841 | compound | T,G |
R3243 | T4844 | T4841 | punct | –,G |
R3244 | T4845 | T4841 | punct | -,G |
R3245 | T4846 | T4841 | amod | rich,G |
R3246 | T4847 | T4838 | punct | ),hetero-bubble |
R3247 | T4848 | T4849 | prep | in,is |
R3248 | T4849 | T4838 | relcl | is,hetero-bubble |
R3249 | T4850 | T4848 | pobj | which,in |
R3250 | T4851 | T4852 | nummod | one,strand |
R3251 | T4852 | T4849 | nsubj | strand,is |
R3252 | T4853 | T4854 | npadvmod | T,rich |
R3253 | T4854 | T4849 | acomp | rich,is |
R3254 | T4855 | T4854 | punct | -,rich |
R3255 | T4856 | T4857 | punct | (,same |
R3256 | T4857 | T4854 | parataxis | same,rich |
R3257 | T4858 | T4857 | prep | as,same |
R3258 | T4859 | T4860 | compound | Bub66,T |
R3259 | T4860 | T4858 | pobj | T,as |
R3260 | T4861 | T4860 | punct | /,T |
R3261 | T4862 | T4860 | punct | -,T |
R3262 | T4863 | T4860 | amod | rich,T |
R3263 | T4864 | T4857 | punct | ),same |
R3264 | T4865 | T4849 | cc | and,is |
R3265 | T4866 | T4867 | det | the,strand |
R3266 | T4867 | T4869 | nsubj | strand,is |
R3267 | T4868 | T4867 | amod | other,strand |
R3268 | T4869 | T4849 | conj | is,is |
R3269 | T4870 | T4871 | npadvmod | G,rich |
R3270 | T4871 | T4869 | acomp | rich,is |
R3271 | T4872 | T4871 | punct | -,rich |
R3272 | T4873 | T4874 | punct | (,same |
R3273 | T4874 | T4871 | parataxis | same,rich |
R3274 | T4875 | T4874 | prep | as,same |
R3275 | T4876 | T4877 | compound | Bub66,G |
R3276 | T4877 | T4875 | pobj | G,as |
R3277 | T4878 | T4877 | punct | /,G |
R3278 | T4879 | T4877 | punct | -,G |
R3279 | T4880 | T4877 | amod | rich,G |
R3280 | T4881 | T4874 | punct | ),same |
R3281 | T4882 | T4883 | punct | (,13 |
R3282 | T4883 | T4871 | parataxis | 13,rich |
R3283 | T4884 | T4883 | punct | ),13 |
R3284 | T4885 | T4836 | punct | ", ",constructed |
R3285 | T4886 | T4836 | cc | and,constructed |
R3286 | T4887 | T4888 | compound | helicase,assays |
R3287 | T4888 | T4889 | nsubjpass | assays,conducted |
R3288 | T4889 | T4836 | conj | conducted,constructed |
R3289 | T4890 | T4889 | auxpass | were,conducted |
R3290 | T4891 | T4889 | prep | with,conducted |
R3291 | T4892 | T4893 | amod | increasing,amount |
R3292 | T4893 | T4891 | pobj | amount,with |
R3293 | T4894 | T4893 | prep | of,amount |
R3294 | T4895 | T4894 | pobj | Mcm4,of |
R3295 | T4896 | T4895 | punct | /,Mcm4 |
R3296 | T4897 | T4895 | nummod | 6,Mcm4 |
R3297 | T4898 | T4895 | punct | /,Mcm4 |
R3298 | T4899 | T4895 | nummod | 7,Mcm4 |
R3299 | T4900 | T4889 | punct | .,conducted |
R3300 | T4902 | T4903 | advmod | Only,unwinding |
R3301 | T4903 | T4905 | nsubjpass | unwinding,detected |
R3302 | T4904 | T4903 | amod | weak,unwinding |
R3303 | T4906 | T4905 | auxpass | was,detected |
R3304 | T4907 | T4905 | prep | on,detected |
R3305 | T4908 | T4909 | det | this,substrate |
R3306 | T4909 | T4907 | pobj | substrate,on |
R3307 | T4910 | T4905 | prep | compared,detected |
R3308 | T4911 | T4910 | prep | to,compared |
R3309 | T4912 | T4913 | compound | Bub66,T |
R3310 | T4913 | T4911 | pobj | T,to |
R3311 | T4914 | T4913 | punct | /,T |
R3312 | T4915 | T4913 | punct | -,T |
R3313 | T4916 | T4913 | amod | rich,T |
R3314 | T4917 | T4918 | punct | (,3A |
R3315 | T4918 | T4905 | parataxis | 3A,detected |
R3316 | T4919 | T4918 | compound | Figure,3A |
R3317 | T4920 | T4918 | punct | ),3A |
R3318 | T4921 | T4905 | punct | .,detected |
R3319 | T4923 | T4924 | mark | Since,bind |
R3320 | T4924 | T4931 | advcl | bind,is |
R3321 | T4925 | T4924 | nsubj | Mcm4,bind |
R3322 | T4926 | T4925 | punct | /,Mcm4 |
R3323 | T4927 | T4925 | nummod | 6,Mcm4 |
R3324 | T4928 | T4925 | punct | /,Mcm4 |
R3325 | T4929 | T4925 | nummod | 7,Mcm4 |
R3326 | T4930 | T4924 | aux | can,bind |
R3327 | T4932 | T4924 | prep | to,bind |
R3328 | T4933 | T4934 | compound | Bub66,G |
R3329 | T4934 | T4932 | pobj | G,to |
R3330 | T4935 | T4934 | punct | /,G |
R3331 | T4936 | T4934 | compound | T,G |
R3332 | T4937 | T4934 | punct | –,G |
R3333 | T4938 | T4934 | punct | -,G |
R3334 | T4939 | T4934 | amod | rich,G |
R3335 | T4940 | T4924 | cc | and,bind |
R3336 | T4941 | T4924 | conj | forms,bind |
R3337 | T4942 | T4943 | det | a,complex |
R3338 | T4943 | T4941 | dobj | complex,forms |
R3339 | T4944 | T4945 | amod | double,hexameric |
R3340 | T4945 | T4943 | amod | hexameric,complex |
R3341 | T4946 | T4947 | punct | (,shown |
R3342 | T4947 | T4941 | parataxis | shown,forms |
R3343 | T4948 | T4947 | nsubj | data,shown |
R3344 | T4949 | T4947 | neg | not,shown |
R3345 | T4950 | T4947 | punct | ),shown |
R3346 | T4951 | T4931 | punct | ", ",is |
R3347 | T4952 | T4953 | det | the,unwinding |
R3348 | T4953 | T4931 | nsubj | unwinding,is |
R3349 | T4954 | T4953 | amod | defective,unwinding |
R3350 | T4955 | T4931 | neg | not,is |
R3351 | T4956 | T4931 | prep | due,is |
R3352 | T4957 | T4956 | pcomp | to,due |
R3353 | T4958 | T4959 | amod | inefficient,loading |
R3354 | T4959 | T4956 | pobj | loading,due |
R3355 | T4960 | T4959 | prep | of,loading |
R3356 | T4961 | T4962 | det | the,helicase |
R3357 | T4962 | T4960 | pobj | helicase,of |
R3358 | T4963 | T4959 | prep | onto,loading |
R3359 | T4964 | T4965 | det | the,substrate |
R3360 | T4965 | T4963 | pobj | substrate,onto |
R3361 | T4966 | T4931 | punct | .,is |
R3362 | T4968 | T4969 | mark | If,dissociates |
R3363 | T4969 | T4979 | advcl | dissociates,result |
R3364 | T4970 | T4971 | nummod | one,hexamer |
R3365 | T4971 | T4969 | nsubj | hexamer,dissociates |
R3366 | T4972 | T4971 | acl | interacting,hexamer |
R3367 | T4973 | T4972 | prep | with,interacting |
R3368 | T4974 | T4975 | det | the,strand |
R3369 | T4975 | T4973 | pobj | strand,with |
R3370 | T4976 | T4977 | npadvmod | thymine,rich |
R3371 | T4977 | T4975 | amod | rich,strand |
R3372 | T4978 | T4977 | punct | -,rich |
R3373 | T4980 | T4969 | prep | from,dissociates |
R3374 | T4981 | T4982 | det | the,hexamer |
R3375 | T4982 | T4980 | pobj | hexamer,from |
R3376 | T4983 | T4982 | amod | other,hexamer |
R3377 | T4984 | T4969 | cc | and,dissociates |
R3378 | T4985 | T4969 | conj | displaces,dissociates |
R3379 | T4986 | T4987 | advmod | only,one |
R3380 | T4987 | T4985 | dobj | one,displaces |
R3381 | T4988 | T4987 | prep | of,one |
R3382 | T4989 | T4990 | det | the,segments |
R3383 | T4990 | T4988 | pobj | segments,of |
R3384 | T4991 | T4990 | compound | duplex,segments |
R3385 | T4992 | T4979 | punct | ", ",result |
R3386 | T4993 | T4979 | advmod | then,result |
R3387 | T4994 | T4979 | nsubj | it,result |
R3388 | T4995 | T4979 | aux | would,result |
R3389 | T4996 | T4979 | prep | in,result |
R3390 | T4997 | T4996 | pobj | generation,in |
R3391 | T4998 | T4997 | prep | of,generation |
R3392 | T4999 | T5000 | compound | Y,fork |
R3393 | T5000 | T5002 | compound | fork,structures |
R3394 | T5001 | T5000 | punct | -,fork |
R3395 | T5002 | T4998 | pobj | structures,of |
R3396 | T5003 | T5004 | dep | which,displaced |
R3397 | T5004 | T5002 | relcl | displaced,structures |
R3398 | T5005 | T5004 | aux | could,displaced |
R3399 | T5006 | T5004 | neg | not,displaced |
R3400 | T5007 | T5004 | auxpass | be,displaced |
R3401 | T5008 | T5004 | advmod | further,displaced |
R3402 | T5009 | T5004 | prep | due,displaced |
R3403 | T5010 | T5009 | pcomp | to,due |
R3404 | T5011 | T5012 | det | the,presence |
R3405 | T5012 | T5009 | pobj | presence,due |
R3406 | T5013 | T5012 | prep | of,presence |
R3407 | T5014 | T5015 | npadvmod | G,rich |
R3408 | T5015 | T5017 | amod | rich,tail |
R3409 | T5016 | T5015 | punct | -,rich |
R3410 | T5017 | T5013 | pobj | tail,of |
R3411 | T5018 | T5017 | nummod | 3,tail |
R3412 | T5019 | T5018 | punct | ′,3 |
R3413 | T5020 | T5017 | punct | -,tail |
R3414 | T5021 | T5004 | cc | and,displaced |
R3415 | T5022 | T5023 | aux | would,appear |
R3416 | T5023 | T5004 | conj | appear,displaced |
R3417 | T5024 | T5023 | prep | on,appear |
R3418 | T5025 | T5026 | det | the,gel |
R3419 | T5026 | T5024 | pobj | gel,on |
R3420 | T5027 | T4979 | punct | .,result |
R3421 | T5029 | T5030 | advmod | However,detect |
R3422 | T5031 | T5030 | punct | ", ",detect |
R3423 | T5032 | T5030 | nsubj | we,detect |
R3424 | T5033 | T5030 | aux | did,detect |
R3425 | T5034 | T5030 | neg | not,detect |
R3426 | T5035 | T5036 | amod | such,intermediates |
R3427 | T5036 | T5030 | dobj | intermediates,detect |
R3428 | T5037 | T5030 | prep | during,detect |
R3429 | T5038 | T5039 | det | the,course |
R3430 | T5039 | T5037 | pobj | course,during |
R3431 | T5040 | T5039 | prep | of,course |
R3432 | T5041 | T5042 | det | the,experiment |
R3433 | T5042 | T5040 | pobj | experiment,of |
R3434 | T5043 | T5044 | punct | (,3B |
R3435 | T5044 | T5030 | parataxis | 3B,detect |
R3436 | T5045 | T5044 | compound | Figure,3B |
R3437 | T5046 | T5044 | punct | ),3B |
R3438 | T5047 | T5030 | punct | ", ",detect |
R3439 | T5048 | T5030 | advcl | suggesting,detect |
R3440 | T5049 | T5050 | mark | that,displaced |
R3441 | T5050 | T5048 | ccomp | displaced,suggesting |
R3442 | T5051 | T5050 | nsubjpass | bubble,displaced |
R3443 | T5052 | T5050 | aux | can,displaced |
R3444 | T5053 | T5050 | auxpass | be,displaced |
R3445 | T5054 | T5050 | advmod | efficiently,displaced |
R3446 | T5055 | T5056 | advmod | only,activated |
R3447 | T5056 | T5050 | advcl | activated,displaced |
R3448 | T5057 | T5056 | advmod | when,activated |
R3449 | T5058 | T5059 | nummod | two,molecules |
R3450 | T5059 | T5056 | nsubjpass | molecules,activated |
R3451 | T5060 | T5059 | prep | of,molecules |
R3452 | T5061 | T5062 | det | the,hexamers |
R3453 | T5062 | T5060 | pobj | hexamers,of |
R3454 | T5063 | T5062 | nmod | Mcm4,hexamers |
R3455 | T5064 | T5063 | punct | /,Mcm4 |
R3456 | T5065 | T5063 | nummod | 6,Mcm4 |
R3457 | T5066 | T5063 | punct | /,Mcm4 |
R3458 | T5067 | T5063 | nummod | 7,Mcm4 |
R3459 | T5068 | T5056 | auxpass | are,activated |
R3460 | T5069 | T5056 | advmod | simultaneously,activated |
R3461 | T5070 | T5030 | punct | .,detect |
craft-ca-core-ex-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4698 | 10-17 | CHEMINF_GO_EXT:chemical_binding_or_bond_formation | denotes | binding |
T4699 | 25-29 | PR_EXT:000010246 | denotes | Mcm4 |
T4700 | 25-33 | GO:0097373 | denotes | Mcm4/6/7 |
T4701 | 34-48 | GO_EXT:double_hexameric_macromolecular_complex | denotes | double hexamer |
T4702 | 78-85 | GO_EXT:hexameric_macromolecular_complex | denotes | hexamer |
T4703 | 86-95 | GO_MOP_EXT:catalysis | denotes | catalyzes |
T4704 | 124-130 | SO:0000985 | denotes | duplex |
T4705 | 177-185 | GO_EXT:hexameric_macromolecular_complex | denotes | hexamers |
T4706 | 300-304 | PR_EXT:000010246 | denotes | Mcm4 |
T4707 | 300-308 | GO:0097373 | denotes | Mcm4/6/7 |
T4708 | 318-325 | CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group | denotes | thymine |
T4709 | 359-374 | SO:0000984 | denotes | single-stranded |
T4710 | 422-423 | CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group | denotes | T |
T4711 | 424-425 | CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group | denotes | G |
T4712 | 455-456 | CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group | denotes | T |
T4713 | 477-478 | CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group | denotes | T |
T4714 | 509-510 | CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group | denotes | G |
T4715 | 531-532 | CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group | denotes | G |
T4716 | 549-557 | GO_EXT:0004386 | denotes | helicase |
T4717 | 606-610 | PR_EXT:000010246 | denotes | Mcm4 |
T4718 | 606-614 | GO:0097373 | denotes | Mcm4/6/7 |
T4719 | 685-686 | CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group | denotes | T |
T4720 | 711-715 | PR_EXT:000010246 | denotes | Mcm4 |
T4721 | 711-719 | GO:0097373 | denotes | Mcm4/6/7 |
T4722 | 724-728 | CHEMINF_GO_EXT:chemical_binding_or_bond_formation | denotes | bind |
T4723 | 738-739 | CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group | denotes | T |
T4724 | 740-741 | CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group | denotes | G |
T4725 | 759-783 | GO_EXT:double_hexameric_macromolecular_complex | denotes | double hexameric complex |
T4726 | 867-875 | GO_EXT:0004386 | denotes | helicase |
T4727 | 903-910 | GO_EXT:hexameric_macromolecular_complex | denotes | hexamer |
T4728 | 932-939 | CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group | denotes | thymine |
T4729 | 979-986 | GO_EXT:hexameric_macromolecular_complex | denotes | hexamer |
T4730 | 1017-1023 | SO:0000985 | denotes | duplex |
T4731 | 1074-1078 | GO:0005657 | denotes | fork |
T4732 | 1150-1151 | CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group | denotes | G |
T4733 | 1355-1364 | CHEBI:36357 | denotes | molecules |
T4734 | 1372-1376 | PR_EXT:000010246 | denotes | Mcm4 |
T4735 | 1372-1380 | GO:0097373 | denotes | Mcm4/6/7 |
T4736 | 1381-1389 | GO_EXT:hexameric_macromolecular_complex | denotes | hexamers |
craft-ca-core-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4676 | 25-29 | PR:000010246 | denotes | Mcm4 |
T4677 | 25-33 | GO:0097373 | denotes | Mcm4/6/7 |
T4678 | 124-130 | SO:0000985 | denotes | duplex |
T4679 | 300-304 | PR:000010246 | denotes | Mcm4 |
T4680 | 300-308 | GO:0097373 | denotes | Mcm4/6/7 |
T4681 | 359-374 | SO:0000984 | denotes | single-stranded |
T4682 | 606-610 | PR:000010246 | denotes | Mcm4 |
T4683 | 606-614 | GO:0097373 | denotes | Mcm4/6/7 |
T4684 | 711-715 | PR:000010246 | denotes | Mcm4 |
T4685 | 711-719 | GO:0097373 | denotes | Mcm4/6/7 |
T4686 | 1017-1023 | SO:0000985 | denotes | duplex |
T4687 | 1074-1078 | GO:0005657 | denotes | fork |
T4688 | 1355-1364 | CHEBI:36357 | denotes | molecules |
T4689 | 1372-1376 | PR:000010246 | denotes | Mcm4 |
T4690 | 1372-1380 | GO:0097373 | denotes | Mcm4/6/7 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
15917436-14609960-76775513 | 540-542 | 14609960 | denotes | 13 |