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PMC:1140370 / 15810-17346 JSONTXT

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Id Subject Object Predicate Lexical cue
T4737 0-4 DT denotes Both
T4738 5-12 NNS denotes strands
T4739 58-66 VBN denotes required
T4740 13-15 IN denotes of
T4741 16-23 NN denotes thymine
T4742 24-28 JJ denotes rich
T4743 23-24 HYPH denotes -
T4744 45-53 NNS denotes segments
T4745 29-35 JJ denotes single
T4746 36-44 VBN denotes stranded
T4747 35-36 HYPH denotes -
T4748 54-57 VBP denotes are
T4749 67-70 IN denotes for
T4750 71-80 JJ denotes efficient
T4751 81-90 NN denotes unwinding
T4752 91-93 IN denotes of
T4753 94-100 NN denotes bubble
T4754 101-104 NN denotes DNA
T4755 105-107 IN denotes by
T4756 108-112 NN denotes Mcm4
T4757 112-113 HYPH denotes /
T4758 113-114 CD denotes 6
T4759 114-115 HYPH denotes /
T4760 115-116 CD denotes 7
T4761 116-257 sentence denotes Symmetric binding of the Mcm4/6/7 double hexamer to bubble suggests that each hexamer catalyzes unwinding of one of the two duplex segments.
T4762 117-126 JJ denotes Symmetric
T4763 127-134 NN denotes binding
T4764 176-184 VBZ denotes suggests
T4765 135-137 IN denotes of
T4766 138-141 DT denotes the
T4767 158-165 NN denotes hexamer
T4768 142-146 NN denotes Mcm4
T4769 146-147 HYPH denotes /
T4770 147-148 CD denotes 6
T4771 148-149 HYPH denotes /
T4772 149-150 CD denotes 7
T4773 151-157 JJ denotes double
T4774 166-168 IN denotes to
T4775 169-175 NN denotes bubble
T4776 185-189 IN denotes that
T4777 203-212 VBZ denotes catalyzes
T4778 190-194 DT denotes each
T4779 195-202 NN denotes hexamer
T4780 213-222 NN denotes unwinding
T4781 223-225 IN denotes of
T4782 226-229 CD denotes one
T4783 230-232 IN denotes of
T4784 233-236 DT denotes the
T4785 248-256 NNS denotes segments
T4786 237-240 CD denotes two
T4787 241-247 NN denotes duplex
T4788 256-257 . denotes .
T4789 257-353 sentence denotes We asked whether activation of both hexamers is required for unwinding of the bubble substrate.
T4790 258-260 PRP denotes We
T4791 261-266 VBD denotes asked
T4792 267-274 IN denotes whether
T4793 306-314 VBN denotes required
T4794 275-285 NN denotes activation
T4795 286-288 IN denotes of
T4796 289-293 DT denotes both
T4797 294-302 NNS denotes hexamers
T4798 303-305 VBZ denotes is
T4799 315-318 IN denotes for
T4800 319-328 NN denotes unwinding
T4801 329-331 IN denotes of
T4802 332-335 DT denotes the
T4803 343-352 NN denotes substrate
T4804 336-342 NN denotes bubble
T4805 352-353 . denotes .
T4806 353-500 sentence denotes The preferred bubble substrate which is efficiently unwound by Mcm4/6/7 contains thymine stretches on both strands of the single-stranded segment.
T4807 354-357 DT denotes The
T4808 375-384 NN denotes substrate
T4809 358-367 JJ denotes preferred
T4810 368-374 NN denotes bubble
T4811 426-434 VBZ denotes contains
T4812 385-390 WDT denotes which
T4813 406-413 VBN denotes unwound
T4814 391-393 VBZ denotes is
T4815 394-405 RB denotes efficiently
T4816 414-416 IN denotes by
T4817 417-421 NN denotes Mcm4
T4818 421-422 HYPH denotes /
T4819 422-423 CD denotes 6
T4820 423-424 HYPH denotes /
T4821 424-425 CD denotes 7
T4822 435-442 NN denotes thymine
T4823 443-452 NNS denotes stretches
T4824 453-455 IN denotes on
T4825 456-460 DT denotes both
T4826 461-468 NNS denotes strands
T4827 469-471 IN denotes of
T4828 472-475 DT denotes the
T4829 492-499 NN denotes segment
T4830 476-482 JJ denotes single
T4831 483-491 VBN denotes stranded
T4832 482-483 HYPH denotes -
T4833 499-500 . denotes .
T4834 500-732 sentence denotes We constructed a hetero-bubble (Bub66/T–G-rich) in which one strand is T-rich (same as Bub66/T-rich) and the other strand is G-rich (same as Bub66/G-rich) (13), and helicase assays were conducted with increasing amount of Mcm4/6/7.
T4835 501-503 PRP denotes We
T4836 504-515 VBD denotes constructed
T4837 516-517 DT denotes a
T4838 518-531 JJ denotes hetero-bubble
T4839 532-533 -LRB- denotes (
T4840 533-538 NN denotes Bub66
T4841 541-542 NN denotes G
T4842 538-539 HYPH denotes /
T4843 539-540 NN denotes T
T4844 540-541 HYPH denotes –
T4845 542-543 HYPH denotes -
T4846 543-547 JJ denotes rich
T4847 547-548 -RRB- denotes )
T4848 549-551 IN denotes in
T4849 569-571 VBZ denotes is
T4850 552-557 WDT denotes which
T4851 558-561 CD denotes one
T4852 562-568 NN denotes strand
T4853 572-573 NN denotes T
T4854 574-578 JJ denotes rich
T4855 573-574 HYPH denotes -
T4856 579-580 -LRB- denotes (
T4857 580-584 JJ denotes same
T4858 585-587 IN denotes as
T4859 588-593 NN denotes Bub66
T4860 594-595 NN denotes T
T4861 593-594 HYPH denotes /
T4862 595-596 HYPH denotes -
T4863 596-600 JJ denotes rich
T4864 600-601 -RRB- denotes )
T4865 602-605 CC denotes and
T4866 606-609 DT denotes the
T4867 616-622 NN denotes strand
T4868 610-615 JJ denotes other
T4869 623-625 VBZ denotes is
T4870 626-627 NN denotes G
T4871 628-632 JJ denotes rich
T4872 627-628 HYPH denotes -
T4873 633-634 -LRB- denotes (
T4874 634-638 JJ denotes same
T4875 639-641 IN denotes as
T4876 642-647 NN denotes Bub66
T4877 648-649 NN denotes G
T4878 647-648 HYPH denotes /
T4879 649-650 HYPH denotes -
T4880 650-654 JJ denotes rich
T4881 654-655 -RRB- denotes )
T4882 656-657 -LRB- denotes (
T4883 657-659 CD denotes 13
T4884 659-660 -RRB- denotes )
T4885 660-662 , denotes ,
T4886 662-665 CC denotes and
T4887 666-674 NN denotes helicase
T4888 675-681 NNS denotes assays
T4889 687-696 VBN denotes conducted
T4890 682-686 VBD denotes were
T4891 697-701 IN denotes with
T4892 702-712 VBG denotes increasing
T4893 713-719 NN denotes amount
T4894 720-722 IN denotes of
T4895 723-727 NN denotes Mcm4
T4896 727-728 HYPH denotes /
T4897 728-729 CD denotes 6
T4898 729-730 HYPH denotes /
T4899 730-731 CD denotes 7
T4900 731-732 . denotes .
T4901 732-821 sentence denotes Only weak unwinding was detected on this substrate compared to Bub66/T-rich (Figure 3A).
T4902 733-737 RB denotes Only
T4903 743-752 NN denotes unwinding
T4904 738-742 JJ denotes weak
T4905 757-765 VBN denotes detected
T4906 753-756 VBD denotes was
T4907 766-768 IN denotes on
T4908 769-773 DT denotes this
T4909 774-783 NN denotes substrate
T4910 784-792 VBN denotes compared
T4911 793-795 IN denotes to
T4912 796-801 NN denotes Bub66
T4913 802-803 NN denotes T
T4914 801-802 HYPH denotes /
T4915 803-804 HYPH denotes -
T4916 804-808 JJ denotes rich
T4917 809-810 -LRB- denotes (
T4918 817-819 NN denotes 3A
T4919 810-816 NN denotes Figure
T4920 819-820 -RRB- denotes )
T4921 820-821 . denotes .
T4922 821-1012 sentence denotes Since Mcm4/6/7 can bind to Bub66/T–G-rich and forms a double hexameric complex (data not shown), the defective unwinding is not due to inefficient loading of the helicase onto the substrate.
T4923 822-827 IN denotes Since
T4924 841-845 VB denotes bind
T4925 828-832 NN denotes Mcm4
T4926 832-833 HYPH denotes /
T4927 833-834 CD denotes 6
T4928 834-835 HYPH denotes /
T4929 835-836 CD denotes 7
T4930 837-840 MD denotes can
T4931 943-945 VBZ denotes is
T4932 846-848 IN denotes to
T4933 849-854 NN denotes Bub66
T4934 857-858 NN denotes G
T4935 854-855 HYPH denotes /
T4936 855-856 NN denotes T
T4937 856-857 HYPH denotes –
T4938 858-859 HYPH denotes -
T4939 859-863 JJ denotes rich
T4940 864-867 CC denotes and
T4941 868-873 VBZ denotes forms
T4942 874-875 DT denotes a
T4943 893-900 NN denotes complex
T4944 876-882 JJ denotes double
T4945 883-892 JJ denotes hexameric
T4946 901-902 -LRB- denotes (
T4947 911-916 VBN denotes shown
T4948 902-906 NNS denotes data
T4949 907-910 RB denotes not
T4950 916-917 -RRB- denotes )
T4951 917-919 , denotes ,
T4952 919-922 DT denotes the
T4953 933-942 NN denotes unwinding
T4954 923-932 JJ denotes defective
T4955 946-949 RB denotes not
T4956 950-953 IN denotes due
T4957 954-956 IN denotes to
T4958 957-968 JJ denotes inefficient
T4959 969-976 NN denotes loading
T4960 977-979 IN denotes of
T4961 980-983 DT denotes the
T4962 984-992 NN denotes helicase
T4963 993-997 IN denotes onto
T4964 998-1001 DT denotes the
T4965 1002-1011 NN denotes substrate
T4966 1011-1012 . denotes .
T4967 1012-1310 sentence denotes If one hexamer interacting with the thymine-rich strand dissociates from the other hexamer and displaces only one of the duplex segments, then it would result in generation of Y-fork structures which could not be further displaced due to the presence of G-rich 3′-tail and would appear on the gel.
T4968 1013-1015 IN denotes If
T4969 1069-1080 VBZ denotes dissociates
T4970 1016-1019 CD denotes one
T4971 1020-1027 NN denotes hexamer
T4972 1028-1039 VBG denotes interacting
T4973 1040-1044 IN denotes with
T4974 1045-1048 DT denotes the
T4975 1062-1068 NN denotes strand
T4976 1049-1056 NN denotes thymine
T4977 1057-1061 JJ denotes rich
T4978 1056-1057 HYPH denotes -
T4979 1165-1171 VB denotes result
T4980 1081-1085 IN denotes from
T4981 1086-1089 DT denotes the
T4982 1096-1103 NN denotes hexamer
T4983 1090-1095 JJ denotes other
T4984 1104-1107 CC denotes and
T4985 1108-1117 VBZ denotes displaces
T4986 1118-1122 RB denotes only
T4987 1123-1126 CD denotes one
T4988 1127-1129 IN denotes of
T4989 1130-1133 DT denotes the
T4990 1141-1149 NNS denotes segments
T4991 1134-1140 NN denotes duplex
T4992 1149-1151 , denotes ,
T4993 1151-1155 RB denotes then
T4994 1156-1158 PRP denotes it
T4995 1159-1164 MD denotes would
T4996 1172-1174 IN denotes in
T4997 1175-1185 NN denotes generation
T4998 1186-1188 IN denotes of
T4999 1189-1190 NN denotes Y
T5000 1191-1195 NN denotes fork
T5001 1190-1191 HYPH denotes -
T5002 1196-1206 NNS denotes structures
T5003 1207-1212 WDT denotes which
T5004 1234-1243 VBN denotes displaced
T5005 1213-1218 MD denotes could
T5006 1219-1222 RB denotes not
T5007 1223-1225 VB denotes be
T5008 1226-1233 RB denotes further
T5009 1244-1247 IN denotes due
T5010 1248-1250 IN denotes to
T5011 1251-1254 DT denotes the
T5012 1255-1263 NN denotes presence
T5013 1264-1266 IN denotes of
T5014 1267-1268 NN denotes G
T5015 1269-1273 JJ denotes rich
T5016 1268-1269 HYPH denotes -
T5017 1277-1281 NN denotes tail
T5018 1274-1275 CD denotes 3
T5019 1275-1276 SYM denotes ′
T5020 1276-1277 HYPH denotes -
T5021 1282-1285 CC denotes and
T5022 1286-1291 MD denotes would
T5023 1292-1298 VB denotes appear
T5024 1299-1301 IN denotes on
T5025 1302-1305 DT denotes the
T5026 1306-1309 NN denotes gel
T5027 1309-1310 . denotes .
T5028 1310-1536 sentence denotes However, we did not detect such intermediates during the course of the experiment (Figure 3B), suggesting that bubble can be displaced efficiently only when two molecules of the Mcm4/6/7 hexamers are simultaneously activated.
T5029 1311-1318 RB denotes However
T5030 1331-1337 VB denotes detect
T5031 1318-1320 , denotes ,
T5032 1320-1322 PRP denotes we
T5033 1323-1326 VBD denotes did
T5034 1327-1330 RB denotes not
T5035 1338-1342 JJ denotes such
T5036 1343-1356 NNS denotes intermediates
T5037 1357-1363 IN denotes during
T5038 1364-1367 DT denotes the
T5039 1368-1374 NN denotes course
T5040 1375-1377 IN denotes of
T5041 1378-1381 DT denotes the
T5042 1382-1392 NN denotes experiment
T5043 1393-1394 -LRB- denotes (
T5044 1401-1403 NN denotes 3B
T5045 1394-1400 NN denotes Figure
T5046 1403-1404 -RRB- denotes )
T5047 1404-1406 , denotes ,
T5048 1406-1416 VBG denotes suggesting
T5049 1417-1421 IN denotes that
T5050 1436-1445 VBN denotes displaced
T5051 1422-1428 NN denotes bubble
T5052 1429-1432 MD denotes can
T5053 1433-1435 VB denotes be
T5054 1446-1457 RB denotes efficiently
T5055 1458-1462 RB denotes only
T5056 1526-1535 VBN denotes activated
T5057 1463-1467 WRB denotes when
T5058 1468-1471 CD denotes two
T5059 1472-1481 NNS denotes molecules
T5060 1482-1484 IN denotes of
T5061 1485-1488 DT denotes the
T5062 1498-1506 NNS denotes hexamers
T5063 1489-1493 NN denotes Mcm4
T5064 1493-1494 HYPH denotes /
T5065 1494-1495 CD denotes 6
T5066 1495-1496 HYPH denotes /
T5067 1496-1497 CD denotes 7
T5068 1507-1510 VBP denotes are
T5069 1511-1525 RB denotes simultaneously
T5070 1535-1536 . denotes .
R3145 T4737 T4738 det Both,strands
R3146 T4738 T4739 nsubjpass strands,required
R3147 T4740 T4738 prep of,strands
R3148 T4741 T4742 npadvmod thymine,rich
R3149 T4742 T4744 amod rich,segments
R3150 T4743 T4742 punct -,rich
R3151 T4744 T4740 pobj segments,of
R3152 T4745 T4746 amod single,stranded
R3153 T4746 T4744 amod stranded,segments
R3154 T4747 T4746 punct -,stranded
R3155 T4748 T4739 auxpass are,required
R3156 T4749 T4739 prep for,required
R3157 T4750 T4751 amod efficient,unwinding
R3158 T4751 T4749 pobj unwinding,for
R3159 T4752 T4751 prep of,unwinding
R3160 T4753 T4754 compound bubble,DNA
R3161 T4754 T4752 pobj DNA,of
R3162 T4755 T4751 prep by,unwinding
R3163 T4756 T4755 pobj Mcm4,by
R3164 T4757 T4756 punct /,Mcm4
R3165 T4758 T4756 nummod 6,Mcm4
R3166 T4759 T4756 punct /,Mcm4
R3167 T4760 T4756 nummod 7,Mcm4
R3168 T4762 T4763 amod Symmetric,binding
R3169 T4763 T4764 nsubj binding,suggests
R3170 T4765 T4763 prep of,binding
R3171 T4766 T4767 det the,hexamer
R3172 T4767 T4765 pobj hexamer,of
R3173 T4768 T4767 nmod Mcm4,hexamer
R3174 T4769 T4768 punct /,Mcm4
R3175 T4770 T4768 nummod 6,Mcm4
R3176 T4771 T4768 punct /,Mcm4
R3177 T4772 T4768 nummod 7,Mcm4
R3178 T4773 T4767 amod double,hexamer
R3179 T4774 T4763 prep to,binding
R3180 T4775 T4774 pobj bubble,to
R3181 T4776 T4777 mark that,catalyzes
R3182 T4777 T4764 ccomp catalyzes,suggests
R3183 T4778 T4779 det each,hexamer
R3184 T4779 T4777 nsubj hexamer,catalyzes
R3185 T4780 T4777 dobj unwinding,catalyzes
R3186 T4781 T4780 prep of,unwinding
R3187 T4782 T4781 pobj one,of
R3188 T4783 T4782 prep of,one
R3189 T4784 T4785 det the,segments
R3190 T4785 T4783 pobj segments,of
R3191 T4786 T4785 nummod two,segments
R3192 T4787 T4785 compound duplex,segments
R3193 T4788 T4764 punct .,suggests
R3194 T4790 T4791 nsubj We,asked
R3195 T4792 T4793 mark whether,required
R3196 T4793 T4791 ccomp required,asked
R3197 T4794 T4793 nsubjpass activation,required
R3198 T4795 T4794 prep of,activation
R3199 T4796 T4797 det both,hexamers
R3200 T4797 T4795 pobj hexamers,of
R3201 T4798 T4793 auxpass is,required
R3202 T4799 T4793 prep for,required
R3203 T4800 T4799 pobj unwinding,for
R3204 T4801 T4800 prep of,unwinding
R3205 T4802 T4803 det the,substrate
R3206 T4803 T4801 pobj substrate,of
R3207 T4804 T4803 compound bubble,substrate
R3208 T4805 T4791 punct .,asked
R3209 T4807 T4808 det The,substrate
R3210 T4808 T4811 nsubj substrate,contains
R3211 T4809 T4808 amod preferred,substrate
R3212 T4810 T4808 compound bubble,substrate
R3213 T4812 T4813 dep which,unwound
R3214 T4813 T4808 relcl unwound,substrate
R3215 T4814 T4813 auxpass is,unwound
R3216 T4815 T4813 advmod efficiently,unwound
R3217 T4816 T4813 agent by,unwound
R3218 T4817 T4816 pobj Mcm4,by
R3219 T4818 T4817 punct /,Mcm4
R3220 T4819 T4817 nummod 6,Mcm4
R3221 T4820 T4817 punct /,Mcm4
R3222 T4821 T4817 nummod 7,Mcm4
R3223 T4822 T4823 compound thymine,stretches
R3224 T4823 T4811 dobj stretches,contains
R3225 T4824 T4823 prep on,stretches
R3226 T4825 T4826 det both,strands
R3227 T4826 T4824 pobj strands,on
R3228 T4827 T4826 prep of,strands
R3229 T4828 T4829 det the,segment
R3230 T4829 T4827 pobj segment,of
R3231 T4830 T4831 amod single,stranded
R3232 T4831 T4829 amod stranded,segment
R3233 T4832 T4831 punct -,stranded
R3234 T4833 T4811 punct .,contains
R3235 T4835 T4836 nsubj We,constructed
R3236 T4837 T4838 det a,hetero-bubble
R3237 T4838 T4836 dobj hetero-bubble,constructed
R3238 T4839 T4838 punct (,hetero-bubble
R3239 T4840 T4841 compound Bub66,G
R3240 T4841 T4838 appos G,hetero-bubble
R3241 T4842 T4841 punct /,G
R3242 T4843 T4841 compound T,G
R3243 T4844 T4841 punct –,G
R3244 T4845 T4841 punct -,G
R3245 T4846 T4841 amod rich,G
R3246 T4847 T4838 punct ),hetero-bubble
R3247 T4848 T4849 prep in,is
R3248 T4849 T4838 relcl is,hetero-bubble
R3249 T4850 T4848 pobj which,in
R3250 T4851 T4852 nummod one,strand
R3251 T4852 T4849 nsubj strand,is
R3252 T4853 T4854 npadvmod T,rich
R3253 T4854 T4849 acomp rich,is
R3254 T4855 T4854 punct -,rich
R3255 T4856 T4857 punct (,same
R3256 T4857 T4854 parataxis same,rich
R3257 T4858 T4857 prep as,same
R3258 T4859 T4860 compound Bub66,T
R3259 T4860 T4858 pobj T,as
R3260 T4861 T4860 punct /,T
R3261 T4862 T4860 punct -,T
R3262 T4863 T4860 amod rich,T
R3263 T4864 T4857 punct ),same
R3264 T4865 T4849 cc and,is
R3265 T4866 T4867 det the,strand
R3266 T4867 T4869 nsubj strand,is
R3267 T4868 T4867 amod other,strand
R3268 T4869 T4849 conj is,is
R3269 T4870 T4871 npadvmod G,rich
R3270 T4871 T4869 acomp rich,is
R3271 T4872 T4871 punct -,rich
R3272 T4873 T4874 punct (,same
R3273 T4874 T4871 parataxis same,rich
R3274 T4875 T4874 prep as,same
R3275 T4876 T4877 compound Bub66,G
R3276 T4877 T4875 pobj G,as
R3277 T4878 T4877 punct /,G
R3278 T4879 T4877 punct -,G
R3279 T4880 T4877 amod rich,G
R3280 T4881 T4874 punct ),same
R3281 T4882 T4883 punct (,13
R3282 T4883 T4871 parataxis 13,rich
R3283 T4884 T4883 punct ),13
R3284 T4885 T4836 punct ", ",constructed
R3285 T4886 T4836 cc and,constructed
R3286 T4887 T4888 compound helicase,assays
R3287 T4888 T4889 nsubjpass assays,conducted
R3288 T4889 T4836 conj conducted,constructed
R3289 T4890 T4889 auxpass were,conducted
R3290 T4891 T4889 prep with,conducted
R3291 T4892 T4893 amod increasing,amount
R3292 T4893 T4891 pobj amount,with
R3293 T4894 T4893 prep of,amount
R3294 T4895 T4894 pobj Mcm4,of
R3295 T4896 T4895 punct /,Mcm4
R3296 T4897 T4895 nummod 6,Mcm4
R3297 T4898 T4895 punct /,Mcm4
R3298 T4899 T4895 nummod 7,Mcm4
R3299 T4900 T4889 punct .,conducted
R3300 T4902 T4903 advmod Only,unwinding
R3301 T4903 T4905 nsubjpass unwinding,detected
R3302 T4904 T4903 amod weak,unwinding
R3303 T4906 T4905 auxpass was,detected
R3304 T4907 T4905 prep on,detected
R3305 T4908 T4909 det this,substrate
R3306 T4909 T4907 pobj substrate,on
R3307 T4910 T4905 prep compared,detected
R3308 T4911 T4910 prep to,compared
R3309 T4912 T4913 compound Bub66,T
R3310 T4913 T4911 pobj T,to
R3311 T4914 T4913 punct /,T
R3312 T4915 T4913 punct -,T
R3313 T4916 T4913 amod rich,T
R3314 T4917 T4918 punct (,3A
R3315 T4918 T4905 parataxis 3A,detected
R3316 T4919 T4918 compound Figure,3A
R3317 T4920 T4918 punct ),3A
R3318 T4921 T4905 punct .,detected
R3319 T4923 T4924 mark Since,bind
R3320 T4924 T4931 advcl bind,is
R3321 T4925 T4924 nsubj Mcm4,bind
R3322 T4926 T4925 punct /,Mcm4
R3323 T4927 T4925 nummod 6,Mcm4
R3324 T4928 T4925 punct /,Mcm4
R3325 T4929 T4925 nummod 7,Mcm4
R3326 T4930 T4924 aux can,bind
R3327 T4932 T4924 prep to,bind
R3328 T4933 T4934 compound Bub66,G
R3329 T4934 T4932 pobj G,to
R3330 T4935 T4934 punct /,G
R3331 T4936 T4934 compound T,G
R3332 T4937 T4934 punct –,G
R3333 T4938 T4934 punct -,G
R3334 T4939 T4934 amod rich,G
R3335 T4940 T4924 cc and,bind
R3336 T4941 T4924 conj forms,bind
R3337 T4942 T4943 det a,complex
R3338 T4943 T4941 dobj complex,forms
R3339 T4944 T4945 amod double,hexameric
R3340 T4945 T4943 amod hexameric,complex
R3341 T4946 T4947 punct (,shown
R3342 T4947 T4941 parataxis shown,forms
R3343 T4948 T4947 nsubj data,shown
R3344 T4949 T4947 neg not,shown
R3345 T4950 T4947 punct ),shown
R3346 T4951 T4931 punct ", ",is
R3347 T4952 T4953 det the,unwinding
R3348 T4953 T4931 nsubj unwinding,is
R3349 T4954 T4953 amod defective,unwinding
R3350 T4955 T4931 neg not,is
R3351 T4956 T4931 prep due,is
R3352 T4957 T4956 pcomp to,due
R3353 T4958 T4959 amod inefficient,loading
R3354 T4959 T4956 pobj loading,due
R3355 T4960 T4959 prep of,loading
R3356 T4961 T4962 det the,helicase
R3357 T4962 T4960 pobj helicase,of
R3358 T4963 T4959 prep onto,loading
R3359 T4964 T4965 det the,substrate
R3360 T4965 T4963 pobj substrate,onto
R3361 T4966 T4931 punct .,is
R3362 T4968 T4969 mark If,dissociates
R3363 T4969 T4979 advcl dissociates,result
R3364 T4970 T4971 nummod one,hexamer
R3365 T4971 T4969 nsubj hexamer,dissociates
R3366 T4972 T4971 acl interacting,hexamer
R3367 T4973 T4972 prep with,interacting
R3368 T4974 T4975 det the,strand
R3369 T4975 T4973 pobj strand,with
R3370 T4976 T4977 npadvmod thymine,rich
R3371 T4977 T4975 amod rich,strand
R3372 T4978 T4977 punct -,rich
R3373 T4980 T4969 prep from,dissociates
R3374 T4981 T4982 det the,hexamer
R3375 T4982 T4980 pobj hexamer,from
R3376 T4983 T4982 amod other,hexamer
R3377 T4984 T4969 cc and,dissociates
R3378 T4985 T4969 conj displaces,dissociates
R3379 T4986 T4987 advmod only,one
R3380 T4987 T4985 dobj one,displaces
R3381 T4988 T4987 prep of,one
R3382 T4989 T4990 det the,segments
R3383 T4990 T4988 pobj segments,of
R3384 T4991 T4990 compound duplex,segments
R3385 T4992 T4979 punct ", ",result
R3386 T4993 T4979 advmod then,result
R3387 T4994 T4979 nsubj it,result
R3388 T4995 T4979 aux would,result
R3389 T4996 T4979 prep in,result
R3390 T4997 T4996 pobj generation,in
R3391 T4998 T4997 prep of,generation
R3392 T4999 T5000 compound Y,fork
R3393 T5000 T5002 compound fork,structures
R3394 T5001 T5000 punct -,fork
R3395 T5002 T4998 pobj structures,of
R3396 T5003 T5004 dep which,displaced
R3397 T5004 T5002 relcl displaced,structures
R3398 T5005 T5004 aux could,displaced
R3399 T5006 T5004 neg not,displaced
R3400 T5007 T5004 auxpass be,displaced
R3401 T5008 T5004 advmod further,displaced
R3402 T5009 T5004 prep due,displaced
R3403 T5010 T5009 pcomp to,due
R3404 T5011 T5012 det the,presence
R3405 T5012 T5009 pobj presence,due
R3406 T5013 T5012 prep of,presence
R3407 T5014 T5015 npadvmod G,rich
R3408 T5015 T5017 amod rich,tail
R3409 T5016 T5015 punct -,rich
R3410 T5017 T5013 pobj tail,of
R3411 T5018 T5017 nummod 3,tail
R3412 T5019 T5018 punct ′,3
R3413 T5020 T5017 punct -,tail
R3414 T5021 T5004 cc and,displaced
R3415 T5022 T5023 aux would,appear
R3416 T5023 T5004 conj appear,displaced
R3417 T5024 T5023 prep on,appear
R3418 T5025 T5026 det the,gel
R3419 T5026 T5024 pobj gel,on
R3420 T5027 T4979 punct .,result
R3421 T5029 T5030 advmod However,detect
R3422 T5031 T5030 punct ", ",detect
R3423 T5032 T5030 nsubj we,detect
R3424 T5033 T5030 aux did,detect
R3425 T5034 T5030 neg not,detect
R3426 T5035 T5036 amod such,intermediates
R3427 T5036 T5030 dobj intermediates,detect
R3428 T5037 T5030 prep during,detect
R3429 T5038 T5039 det the,course
R3430 T5039 T5037 pobj course,during
R3431 T5040 T5039 prep of,course
R3432 T5041 T5042 det the,experiment
R3433 T5042 T5040 pobj experiment,of
R3434 T5043 T5044 punct (,3B
R3435 T5044 T5030 parataxis 3B,detect
R3436 T5045 T5044 compound Figure,3B
R3437 T5046 T5044 punct ),3B
R3438 T5047 T5030 punct ", ",detect
R3439 T5048 T5030 advcl suggesting,detect
R3440 T5049 T5050 mark that,displaced
R3441 T5050 T5048 ccomp displaced,suggesting
R3442 T5051 T5050 nsubjpass bubble,displaced
R3443 T5052 T5050 aux can,displaced
R3444 T5053 T5050 auxpass be,displaced
R3445 T5054 T5050 advmod efficiently,displaced
R3446 T5055 T5056 advmod only,activated
R3447 T5056 T5050 advcl activated,displaced
R3448 T5057 T5056 advmod when,activated
R3449 T5058 T5059 nummod two,molecules
R3450 T5059 T5056 nsubjpass molecules,activated
R3451 T5060 T5059 prep of,molecules
R3452 T5061 T5062 det the,hexamers
R3453 T5062 T5060 pobj hexamers,of
R3454 T5063 T5062 nmod Mcm4,hexamers
R3455 T5064 T5063 punct /,Mcm4
R3456 T5065 T5063 nummod 6,Mcm4
R3457 T5066 T5063 punct /,Mcm4
R3458 T5067 T5063 nummod 7,Mcm4
R3459 T5068 T5056 auxpass are,activated
R3460 T5069 T5056 advmod simultaneously,activated
R3461 T5070 T5030 punct .,detect

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T4691 16-23 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T4692 29-44 SO:0000984 denotes single-stranded
T4693 81-93 _FRAGMENT denotes unwinding of
T4694 101-104 GO:0032508 denotes DNA
T4695 101-104 CHEBI_SO_EXT:DNA denotes DNA
T4696 108-112 PR_EXT:000010246 denotes Mcm4
T4697 108-116 GO:0097373 denotes Mcm4/6/7
T4698 127-134 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T4699 142-146 PR_EXT:000010246 denotes Mcm4
T4700 142-150 GO:0097373 denotes Mcm4/6/7
T4701 151-165 GO_EXT:double_hexameric_macromolecular_complex denotes double hexamer
T4702 195-202 GO_EXT:hexameric_macromolecular_complex denotes hexamer
T4703 203-212 GO_MOP_EXT:catalysis denotes catalyzes
T4704 241-247 SO:0000985 denotes duplex
T4705 294-302 GO_EXT:hexameric_macromolecular_complex denotes hexamers
T4706 417-421 PR_EXT:000010246 denotes Mcm4
T4707 417-425 GO:0097373 denotes Mcm4/6/7
T4708 435-442 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T4709 476-491 SO:0000984 denotes single-stranded
T4710 539-540 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes T
T4711 541-542 CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes G
T4712 572-573 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes T
T4713 594-595 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes T
T4714 626-627 CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes G
T4715 648-649 CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes G
T4716 666-674 GO_EXT:0004386 denotes helicase
T4717 723-727 PR_EXT:000010246 denotes Mcm4
T4718 723-731 GO:0097373 denotes Mcm4/6/7
T4719 802-803 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes T
T4720 828-832 PR_EXT:000010246 denotes Mcm4
T4721 828-836 GO:0097373 denotes Mcm4/6/7
T4722 841-845 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bind
T4723 855-856 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes T
T4724 857-858 CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes G
T4725 876-900 GO_EXT:double_hexameric_macromolecular_complex denotes double hexameric complex
T4726 984-992 GO_EXT:0004386 denotes helicase
T4727 1020-1027 GO_EXT:hexameric_macromolecular_complex denotes hexamer
T4728 1049-1056 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T4729 1096-1103 GO_EXT:hexameric_macromolecular_complex denotes hexamer
T4730 1134-1140 SO:0000985 denotes duplex
T4731 1191-1195 GO:0005657 denotes fork
T4732 1267-1268 CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes G
T4733 1472-1481 CHEBI:36357 denotes molecules
T4734 1489-1493 PR_EXT:000010246 denotes Mcm4
T4735 1489-1497 GO:0097373 denotes Mcm4/6/7
T4736 1498-1506 GO_EXT:hexameric_macromolecular_complex denotes hexamers
R3144 T4694 T4693 _lexicallyChainedTo DNA,unwinding of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T4671 29-44 SO:0000984 denotes single-stranded
T4672 81-93 _FRAGMENT denotes unwinding of
T4673 101-104 GO:0032508 denotes DNA
T4674 108-112 PR:000010246 denotes Mcm4
T4675 108-116 GO:0097373 denotes Mcm4/6/7
T4676 142-146 PR:000010246 denotes Mcm4
T4677 142-150 GO:0097373 denotes Mcm4/6/7
T4678 241-247 SO:0000985 denotes duplex
T4679 417-421 PR:000010246 denotes Mcm4
T4680 417-425 GO:0097373 denotes Mcm4/6/7
T4681 476-491 SO:0000984 denotes single-stranded
T4682 723-727 PR:000010246 denotes Mcm4
T4683 723-731 GO:0097373 denotes Mcm4/6/7
T4684 828-832 PR:000010246 denotes Mcm4
T4685 828-836 GO:0097373 denotes Mcm4/6/7
T4686 1134-1140 SO:0000985 denotes duplex
T4687 1191-1195 GO:0005657 denotes fork
T4688 1472-1481 CHEBI:36357 denotes molecules
T4689 1489-1493 PR:000010246 denotes Mcm4
T4690 1489-1497 GO:0097373 denotes Mcm4/6/7
R3143 T4673 T4672 _lexicallyChainedTo DNA,unwinding of

2_test

Id Subject Object Predicate Lexical cue
15917436-14609960-76775513 657-659 14609960 denotes 13