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PMC:1140370 / 1525-4607 JSONTXT

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Id Subject Object Predicate Lexical cue
T757 13-16 NN denotes DNA
T758 17-26 NNS denotes helicases
T759 27-33 VBP denotes couple
T760 34-37 DT denotes the
T761 38-48 NN denotes hydrolysis
T762 49-51 IN denotes of
T763 52-62 NN denotes nucleotide
T764 82-94 NN denotes triphosphate
T765 63-65 CC denotes or
T766 66-81 NN denotes deoxynucleotide
T767 95-97 IN denotes to
T768 98-104 NN denotes duplex
T769 105-114 NN denotes unwinding
T770 115-116 -LRB- denotes (
T771 116-117 CD denotes 1
T772 117-118 -RRB- denotes )
T773 118-119 . denotes .
T774 119-266 sentence denotes Coordination of a set of subactivities including nucleotide binding, DNA binding and ATP hydrolysis is required for unwinding of duplex DNA (1,2).
T775 120-132 NN denotes Coordination
T776 223-231 VBN denotes required
T777 133-135 IN denotes of
T778 136-137 DT denotes a
T779 138-141 NN denotes set
T780 142-144 IN denotes of
T781 145-158 NNS denotes subactivities
T782 159-168 VBG denotes including
T783 169-179 NN denotes nucleotide
T784 180-187 NN denotes binding
T785 187-189 , denotes ,
T786 189-192 NN denotes DNA
T787 193-200 NN denotes binding
T788 201-204 CC denotes and
T789 205-208 NN denotes ATP
T790 209-219 NN denotes hydrolysis
T791 220-222 VBZ denotes is
T792 232-235 IN denotes for
T793 236-245 NN denotes unwinding
T794 246-248 IN denotes of
T795 249-255 NN denotes duplex
T796 256-259 NN denotes DNA
T797 260-261 -LRB- denotes (
T798 263-264 CD denotes 2
T799 261-262 CD denotes 1
T800 262-263 , denotes ,
T801 264-265 -RRB- denotes )
T802 265-266 . denotes .
T803 266-402 sentence denotes The hexameric helicases, to which minichromosome maintenance (Mcm) helicase belongs, are known to assemble a ring-like structure (3–5).
T804 267-270 DT denotes The
T805 281-290 NNS denotes helicases
T806 271-280 JJ denotes hexameric
T807 356-361 VBN denotes known
T808 290-292 , denotes ,
T809 292-294 IN denotes to
T810 343-350 VBZ denotes belongs
T811 295-300 WDT denotes which
T812 301-315 NN denotes minichromosome
T813 316-327 NN denotes maintenance
T814 334-342 NN denotes helicase
T815 328-329 -LRB- denotes (
T816 329-332 NN denotes Mcm
T817 332-333 -RRB- denotes )
T818 350-352 , denotes ,
T819 352-355 VBP denotes are
T820 362-364 TO denotes to
T821 365-373 VB denotes assemble
T822 374-375 DT denotes a
T823 386-395 NN denotes structure
T824 376-380 NN denotes ring
T825 381-385 JJ denotes like
T826 380-381 HYPH denotes -
T827 396-397 -LRB- denotes (
T828 397-398 CD denotes 3
T829 398-399 SYM denotes –
T830 399-400 CD denotes 5
T831 400-401 -RRB- denotes )
T832 401-402 . denotes .
T833 402-672 sentence denotes Whereas most of DNA helicases of this group, including simian virus 40 large T-antigen (6), Escherichia coli DnaB (7) and Archaeal Mcm (4,8,9), are composed of a single subunit, the active eukaryotic Mcm helicases are composed of two trimeric Mcm4/6/7 proteins (10–14).
T834 403-410 IN denotes Whereas
T835 551-559 VBN denotes composed
T836 411-415 JJS denotes most
T837 416-418 IN denotes of
T838 419-422 NN denotes DNA
T839 423-432 NNS denotes helicases
T840 433-435 IN denotes of
T841 436-440 DT denotes this
T842 441-446 NN denotes group
T843 446-448 , denotes ,
T844 448-457 VBG denotes including
T845 458-464 JJ denotes simian
T846 465-470 NN denotes virus
T847 482-489 NN denotes antigen
T848 471-473 CD denotes 40
T849 474-479 JJ denotes large
T850 480-481 NN denotes T
T851 481-482 HYPH denotes -
T852 490-491 -LRB- denotes (
T853 491-492 CD denotes 6
T854 492-493 -RRB- denotes )
T855 493-495 , denotes ,
T856 495-506 NNP denotes Escherichia
T857 507-511 NNP denotes coli
T858 512-516 NN denotes DnaB
T859 517-518 -LRB- denotes (
T860 518-519 CD denotes 7
T861 519-520 -RRB- denotes )
T862 521-524 CC denotes and
T863 525-533 JJ denotes Archaeal
T864 534-537 NN denotes Mcm
T865 538-539 -LRB- denotes (
T866 543-544 CD denotes 9
T867 539-540 CD denotes 4
T868 540-541 , denotes ,
T869 541-542 CD denotes 8
T870 542-543 , denotes ,
T871 544-545 -RRB- denotes )
T872 545-547 , denotes ,
T873 547-550 VBP denotes are
T874 621-629 VBN denotes composed
T875 560-562 IN denotes of
T876 563-564 DT denotes a
T877 572-579 NN denotes subunit
T878 565-571 JJ denotes single
T879 579-581 , denotes ,
T880 581-584 DT denotes the
T881 607-616 NNS denotes helicases
T882 585-591 JJ denotes active
T883 592-602 JJ denotes eukaryotic
T884 603-606 NN denotes Mcm
T885 617-620 VBP denotes are
T886 630-632 IN denotes of
T887 633-636 CD denotes two
T888 655-663 NN denotes proteins
T889 637-645 JJ denotes trimeric
T890 646-650 NN denotes Mcm4
T891 650-651 HYPH denotes /
T892 651-652 CD denotes 6
T893 652-653 HYPH denotes /
T894 653-654 CD denotes 7
T895 664-665 -LRB- denotes (
T896 665-667 CD denotes 10
T897 667-668 SYM denotes –
T898 668-670 CD denotes 14
T899 670-671 -RRB- denotes )
T900 671-672 . denotes .
T901 672-788 sentence denotes All the six Mcm 2–7 proteins contain highly conserved DNA-dependent ATPase motifs in their central regions (15,16).
T902 673-676 PDT denotes All
T903 693-701 NN denotes proteins
T904 677-680 DT denotes the
T905 681-684 CD denotes six
T906 685-688 NN denotes Mcm
T907 689-690 CD denotes 2
T908 690-691 SYM denotes –
T909 691-692 CD denotes 7
T910 702-709 VBP denotes contain
T911 710-716 RB denotes highly
T912 717-726 VBN denotes conserved
T913 748-754 NNS denotes motifs
T914 727-730 NN denotes DNA
T915 731-740 JJ denotes dependent
T916 730-731 HYPH denotes -
T917 741-747 NN denotes ATPase
T918 755-757 IN denotes in
T919 758-763 PRP$ denotes their
T920 772-779 NNS denotes regions
T921 764-771 JJ denotes central
T922 780-781 -LRB- denotes (
T923 784-786 CD denotes 16
T924 781-783 CD denotes 15
T925 783-784 , denotes ,
T926 786-787 -RRB- denotes )
T927 787-788 . denotes .
T928 788-961 sentence denotes Among the several stable subcomplexes which MCM proteins can generate, only the Mcm4/6/7 complex has been shown to possess an intrinsic DNA helicase activity (10–14,17–18).
T929 789-794 IN denotes Among
T930 895-900 VBN denotes shown
T931 795-798 DT denotes the
T932 814-826 NNS denotes subcomplexes
T933 799-806 JJ denotes several
T934 807-813 JJ denotes stable
T935 827-832 WDT denotes which
T936 850-858 VB denotes generate
T937 833-836 NN denotes MCM
T938 837-845 NN denotes proteins
T939 846-849 MD denotes can
T940 858-860 , denotes ,
T941 860-864 RB denotes only
T942 878-885 NN denotes complex
T943 865-868 DT denotes the
T944 869-873 NN denotes Mcm4
T945 873-874 HYPH denotes /
T946 874-875 CD denotes 6
T947 875-876 HYPH denotes /
T948 876-877 CD denotes 7
T949 886-889 VBZ denotes has
T950 890-894 VBN denotes been
T951 901-903 TO denotes to
T952 904-911 VB denotes possess
T953 912-914 DT denotes an
T954 938-946 NN denotes activity
T955 915-924 JJ denotes intrinsic
T956 925-928 NN denotes DNA
T957 929-937 NN denotes helicase
T958 947-948 -LRB- denotes (
T959 948-950 CD denotes 10
T960 950-951 SYM denotes –
T961 951-953 CD denotes 14
T962 953-954 , denotes ,
T963 954-956 CD denotes 17
T964 956-957 SYM denotes –
T965 957-959 CD denotes 18
T966 959-960 -RRB- denotes )
T967 960-961 . denotes .
T968 961-1230 sentence denotes While Mcm4, Mcm6 and Mcm7 proteins make distinct contribution to its helicase activity (11–13), Mcm2 or Mcm3/5 inhibit the helicase activity of the Mcm4/6/7 complex by converting its double trimer structure into a heterotetramer or heteropentamer, respectively (3,11).
T969 962-967 IN denotes While
T970 997-1001 VBP denotes make
T971 968-972 NN denotes Mcm4
T972 988-996 NN denotes proteins
T973 972-974 , denotes ,
T974 974-978 NN denotes Mcm6
T975 979-982 CC denotes and
T976 983-987 NN denotes Mcm7
T977 1073-1080 VBP denotes inhibit
T978 1002-1010 JJ denotes distinct
T979 1011-1023 NN denotes contribution
T980 1024-1026 IN denotes to
T981 1027-1030 PRP$ denotes its
T982 1040-1048 NN denotes activity
T983 1031-1039 NN denotes helicase
T984 1049-1050 -LRB- denotes (
T985 1050-1052 CD denotes 11
T986 1052-1053 SYM denotes –
T987 1053-1055 CD denotes 13
T988 1055-1056 -RRB- denotes )
T989 1056-1058 , denotes ,
T990 1058-1062 NN denotes Mcm2
T991 1063-1065 CC denotes or
T992 1066-1070 NN denotes Mcm3
T993 1070-1071 HYPH denotes /
T994 1071-1072 CD denotes 5
T995 1081-1084 DT denotes the
T996 1094-1102 NN denotes activity
T997 1085-1093 NN denotes helicase
T998 1103-1105 IN denotes of
T999 1106-1109 DT denotes the
T1000 1119-1126 NN denotes complex
T1001 1110-1114 NN denotes Mcm4
T1002 1114-1115 HYPH denotes /
T1003 1115-1116 CD denotes 6
T1004 1116-1117 HYPH denotes /
T1005 1117-1118 CD denotes 7
T1006 1127-1129 IN denotes by
T1007 1130-1140 VBG denotes converting
T1008 1141-1144 PRP$ denotes its
T1009 1159-1168 NN denotes structure
T1010 1145-1151 JJ denotes double
T1011 1152-1158 NN denotes trimer
T1012 1169-1173 IN denotes into
T1013 1174-1175 DT denotes a
T1014 1176-1190 NN denotes heterotetramer
T1015 1191-1193 CC denotes or
T1016 1194-1208 NN denotes heteropentamer
T1017 1208-1210 , denotes ,
T1018 1210-1222 RB denotes respectively
T1019 1223-1224 -LRB- denotes (
T1020 1226-1228 CD denotes 11
T1021 1224-1225 CD denotes 3
T1022 1225-1226 , denotes ,
T1023 1228-1229 -RRB- denotes )
T1024 1229-1230 . denotes .
T1025 1230-1465 sentence denotes Chromatin immunoprecipitation assays and genetic characterization in Saccharomyces cerevisiae strongly suggested that Mcm is involved not only in initiation but also in the DNA chain elongation stage as a replicative helicase (19,20).
T1026 1231-1240 NN denotes Chromatin
T1027 1261-1267 NNS denotes assays
T1028 1241-1260 NN denotes immunoprecipitation
T1029 1334-1343 VBD denotes suggested
T1030 1268-1271 CC denotes and
T1031 1272-1279 JJ denotes genetic
T1032 1280-1296 NN denotes characterization
T1033 1297-1299 IN denotes in
T1034 1300-1313 NNP denotes Saccharomyces
T1035 1314-1324 NNP denotes cerevisiae
T1036 1325-1333 RB denotes strongly
T1037 1344-1348 IN denotes that
T1038 1356-1364 VBN denotes involved
T1039 1349-1352 NN denotes Mcm
T1040 1353-1355 VBZ denotes is
T1041 1365-1368 RB denotes not
T1042 1374-1376 IN denotes in
T1043 1369-1373 RB denotes only
T1044 1377-1387 NN denotes initiation
T1045 1388-1391 CC denotes but
T1046 1392-1396 RB denotes also
T1047 1397-1399 IN denotes in
T1048 1400-1403 DT denotes the
T1049 1425-1430 NN denotes stage
T1050 1404-1407 NN denotes DNA
T1051 1414-1424 NN denotes elongation
T1052 1408-1413 NN denotes chain
T1053 1431-1433 IN denotes as
T1054 1434-1435 DT denotes a
T1055 1448-1456 NN denotes helicase
T1056 1436-1447 JJ denotes replicative
T1057 1457-1458 -LRB- denotes (
T1058 1461-1463 CD denotes 20
T1059 1458-1460 CD denotes 19
T1060 1460-1461 , denotes ,
T1061 1463-1464 -RRB- denotes )
T1062 1464-1465 . denotes .
T1063 1465-1678 sentence denotes Consistent with this notion, the processivity of the Schizosaccharomyces pombe and mouse Mcm4/6/7 complexes is significantly stimulated on forked DNA structures and it can unwind duplex DNA of 400–500 bp (13,14).
T1064 1466-1476 JJ denotes Consistent
T1065 1591-1601 VBN denotes stimulated
T1066 1477-1481 IN denotes with
T1067 1482-1486 DT denotes this
T1068 1487-1493 NN denotes notion
T1069 1493-1495 , denotes ,
T1070 1495-1498 DT denotes the
T1071 1499-1511 NN denotes processivity
T1072 1512-1514 IN denotes of
T1073 1515-1518 DT denotes the
T1074 1564-1573 NNS denotes complexes
T1075 1519-1538 NNP denotes Schizosaccharomyces
T1076 1539-1544 NNP denotes pombe
T1077 1545-1548 CC denotes and
T1078 1549-1554 NN denotes mouse
T1079 1555-1559 NN denotes Mcm4
T1080 1559-1560 HYPH denotes /
T1081 1560-1561 CD denotes 6
T1082 1561-1562 HYPH denotes /
T1083 1562-1563 CD denotes 7
T1084 1574-1576 VBZ denotes is
T1085 1577-1590 RB denotes significantly
T1086 1602-1604 IN denotes on
T1087 1605-1611 VBN denotes forked
T1088 1612-1615 NN denotes DNA
T1089 1616-1626 NNS denotes structures
T1090 1627-1630 CC denotes and
T1091 1631-1633 PRP denotes it
T1092 1638-1644 VB denotes unwind
T1093 1634-1637 MD denotes can
T1094 1645-1651 NN denotes duplex
T1095 1652-1655 NN denotes DNA
T1096 1656-1658 IN denotes of
T1097 1659-1662 CD denotes 400
T1098 1663-1666 CD denotes 500
T1099 1662-1663 SYM denotes –
T1100 1667-1669 NN denotes bp
T1101 1670-1671 -LRB- denotes (
T1102 1674-1676 CD denotes 14
T1103 1671-1673 CD denotes 13
T1104 1673-1674 , denotes ,
T1105 1676-1677 -RRB- denotes )
T1106 1677-1678 . denotes .
T1107 1678-1832 sentence denotes Mcm4/6/7 binds to fork and bubble structures in an ATP-dependent manner, and generates a double-hexameric complex, as was shown for T-antigen (13,14,21).
T1108 1679-1683 NN denotes Mcm4
T1109 1688-1693 VBZ denotes binds
T1110 1683-1684 HYPH denotes /
T1111 1684-1685 CD denotes 6
T1112 1685-1686 HYPH denotes /
T1113 1686-1687 CD denotes 7
T1114 1694-1696 IN denotes to
T1115 1697-1701 NN denotes fork
T1116 1713-1723 NNS denotes structures
T1117 1702-1705 CC denotes and
T1118 1706-1712 NN denotes bubble
T1119 1724-1726 IN denotes in
T1120 1727-1729 DT denotes an
T1121 1744-1750 NN denotes manner
T1122 1730-1733 NN denotes ATP
T1123 1734-1743 JJ denotes dependent
T1124 1733-1734 HYPH denotes -
T1125 1750-1752 , denotes ,
T1126 1752-1755 CC denotes and
T1127 1756-1765 VBZ denotes generates
T1128 1766-1767 DT denotes a
T1129 1785-1792 NN denotes complex
T1130 1768-1774 JJ denotes double
T1131 1775-1784 JJ denotes hexameric
T1132 1774-1775 HYPH denotes -
T1133 1792-1794 , denotes ,
T1134 1794-1796 IN denotes as
T1135 1801-1806 VBN denotes shown
T1136 1797-1800 VBD denotes was
T1137 1807-1810 IN denotes for
T1138 1811-1812 NN denotes T
T1139 1813-1820 NN denotes antigen
T1140 1812-1813 HYPH denotes -
T1141 1821-1822 -LRB- denotes (
T1142 1828-1830 CD denotes 21
T1143 1822-1824 CD denotes 13
T1144 1824-1825 , denotes ,
T1145 1825-1827 CD denotes 14
T1146 1827-1828 , denotes ,
T1147 1830-1831 -RRB- denotes )
T1148 1831-1832 . denotes .
T1149 1832-2138 sentence denotes Recently, we reported that the helicase and ATP hydrolysis activities of mammalian Mcm4/6/7 are specifically activated by single-stranded DNA containing stretches of thymine residues and proposed a novel model that Mcm may play a crucial role in selection of replication origins in higher eukaryotes (13).
T1150 1833-1841 RB denotes Recently
T1151 1846-1854 VBD denotes reported
T1152 1841-1843 , denotes ,
T1153 1843-1845 PRP denotes we
T1154 1855-1859 IN denotes that
T1155 1942-1951 VBN denotes activated
T1156 1860-1863 DT denotes the
T1157 1892-1902 NNS denotes activities
T1158 1864-1872 NN denotes helicase
T1159 1873-1876 CC denotes and
T1160 1877-1880 NN denotes ATP
T1161 1881-1891 NN denotes hydrolysis
T1162 1903-1905 IN denotes of
T1163 1906-1915 JJ denotes mammalian
T1164 1916-1920 NN denotes Mcm4
T1165 1920-1921 HYPH denotes /
T1166 1921-1922 CD denotes 6
T1167 1922-1923 HYPH denotes /
T1168 1923-1924 CD denotes 7
T1169 1925-1928 VBP denotes are
T1170 1929-1941 RB denotes specifically
T1171 1952-1954 IN denotes by
T1172 1955-1961 JJ denotes single
T1173 1962-1970 VBN denotes stranded
T1174 1961-1962 HYPH denotes -
T1175 1971-1974 NN denotes DNA
T1176 1975-1985 VBG denotes containing
T1177 1986-1995 NNS denotes stretches
T1178 1996-1998 IN denotes of
T1179 1999-2006 NN denotes thymine
T1180 2007-2015 NNS denotes residues
T1181 2016-2019 CC denotes and
T1182 2020-2028 VBD denotes proposed
T1183 2029-2030 DT denotes a
T1184 2037-2042 NN denotes model
T1185 2031-2036 JJ denotes novel
T1186 2043-2047 IN denotes that
T1187 2056-2060 VB denotes play
T1188 2048-2051 NN denotes Mcm
T1189 2052-2055 MD denotes may
T1190 2061-2062 DT denotes a
T1191 2071-2075 NN denotes role
T1192 2063-2070 JJ denotes crucial
T1193 2076-2078 IN denotes in
T1194 2079-2088 NN denotes selection
T1195 2089-2091 IN denotes of
T1196 2092-2103 NN denotes replication
T1197 2104-2111 NNS denotes origins
T1198 2112-2114 IN denotes in
T1199 2115-2121 JJR denotes higher
T1200 2122-2132 NNS denotes eukaryotes
T1201 2133-2134 -LRB- denotes (
T1202 2134-2136 CD denotes 13
T1203 2136-2137 -RRB- denotes )
T1204 2137-2138 . denotes .
T1205 2138-2437 sentence denotes In this report, in order to clarify the mode of action of the Mcm helicase and obtain insight into how it may function at the replication forks in vivo, we have conducted detailed analyses of helicase action and DNA binding of mouse Mcm4/6/7 helicase using various forked and bubble substrate DNAs.
T1206 2139-2141 IN denotes In
T1207 2300-2309 VBN denotes conducted
T1208 2142-2146 DT denotes this
T1209 2147-2153 NN denotes report
T1210 2153-2155 , denotes ,
T1211 2155-2157 IN denotes in
T1212 2158-2163 NN denotes order
T1213 2164-2166 TO denotes to
T1214 2167-2174 VB denotes clarify
T1215 2175-2178 DT denotes the
T1216 2179-2183 NN denotes mode
T1217 2184-2186 IN denotes of
T1218 2187-2193 NN denotes action
T1219 2194-2196 IN denotes of
T1220 2197-2200 DT denotes the
T1221 2205-2213 NN denotes helicase
T1222 2201-2204 NN denotes Mcm
T1223 2214-2217 CC denotes and
T1224 2218-2224 VB denotes obtain
T1225 2225-2232 NN denotes insight
T1226 2233-2237 IN denotes into
T1227 2238-2241 WRB denotes how
T1228 2249-2257 VB denotes function
T1229 2242-2244 PRP denotes it
T1230 2245-2248 MD denotes may
T1231 2258-2260 IN denotes at
T1232 2261-2264 DT denotes the
T1233 2277-2282 NNS denotes forks
T1234 2265-2276 NN denotes replication
T1235 2283-2285 FW denotes in
T1236 2286-2290 FW denotes vivo
T1237 2290-2292 , denotes ,
T1238 2292-2294 PRP denotes we
T1239 2295-2299 VBP denotes have
T1240 2310-2318 JJ denotes detailed
T1241 2319-2327 NNS denotes analyses
T1242 2328-2330 IN denotes of
T1243 2331-2339 NN denotes helicase
T1244 2340-2346 NN denotes action
T1245 2347-2350 CC denotes and
T1246 2351-2354 NN denotes DNA
T1247 2355-2362 NN denotes binding
T1248 2363-2365 IN denotes of
T1249 2366-2371 NN denotes mouse
T1250 2381-2389 NN denotes helicase
T1251 2372-2376 NN denotes Mcm4
T1252 2376-2377 HYPH denotes /
T1253 2377-2378 CD denotes 6
T1254 2378-2379 HYPH denotes /
T1255 2379-2380 CD denotes 7
T1256 2390-2395 VBG denotes using
T1257 2396-2403 JJ denotes various
T1258 2432-2436 NNS denotes DNAs
T1259 2404-2410 VBN denotes forked
T1260 2411-2414 CC denotes and
T1261 2415-2421 NN denotes bubble
T1262 2422-2431 NN denotes substrate
T1263 2436-2437 . denotes .
T1264 2437-2676 sentence denotes We specifically addressed sequence requirement for the Mcm helicase activation, mode of interaction with DNA substrates and whether the thymine sequences are required for continuous activation of Mcm helicase during the unwinding process.
T1265 2438-2440 PRP denotes We
T1266 2454-2463 VBD denotes addressed
T1267 2441-2453 RB denotes specifically
T1268 2464-2472 NN denotes sequence
T1269 2473-2484 NN denotes requirement
T1270 2485-2488 IN denotes for
T1271 2489-2492 DT denotes the
T1272 2506-2516 NN denotes activation
T1273 2493-2496 NN denotes Mcm
T1274 2497-2505 NN denotes helicase
T1275 2516-2518 , denotes ,
T1276 2518-2522 NN denotes mode
T1277 2523-2525 IN denotes of
T1278 2526-2537 NN denotes interaction
T1279 2538-2542 IN denotes with
T1280 2543-2546 NN denotes DNA
T1281 2547-2557 NNS denotes substrates
T1282 2558-2561 CC denotes and
T1283 2562-2569 IN denotes whether
T1284 2596-2604 VBN denotes required
T1285 2570-2573 DT denotes the
T1286 2582-2591 NNS denotes sequences
T1287 2574-2581 NN denotes thymine
T1288 2592-2595 VBP denotes are
T1289 2605-2608 IN denotes for
T1290 2609-2619 JJ denotes continuous
T1291 2620-2630 NN denotes activation
T1292 2631-2633 IN denotes of
T1293 2634-2637 NN denotes Mcm
T1294 2638-2646 NN denotes helicase
T1295 2647-2653 IN denotes during
T1296 2654-2657 DT denotes the
T1297 2668-2675 NN denotes process
T1298 2658-2667 JJ denotes unwinding
T1299 2675-2676 . denotes .
T1300 2676-2877 sentence denotes The results indicate that mammalian Mcm4/6/7 primarily binds to single-stranded DNA region, and that the extent of helicase activation is related to the thymine content of the single-stranded segment.
T1301 2677-2680 DT denotes The
T1302 2681-2688 NNS denotes results
T1303 2689-2697 VBP denotes indicate
T1304 2698-2702 IN denotes that
T1305 2732-2737 VBZ denotes binds
T1306 2703-2712 JJ denotes mammalian
T1307 2713-2717 NN denotes Mcm4
T1308 2717-2718 HYPH denotes /
T1309 2718-2719 CD denotes 6
T1310 2719-2720 HYPH denotes /
T1311 2720-2721 CD denotes 7
T1312 2722-2731 RB denotes primarily
T1313 2738-2740 IN denotes to
T1314 2741-2747 JJ denotes single
T1315 2748-2756 VBN denotes stranded
T1316 2747-2748 HYPH denotes -
T1317 2761-2767 NN denotes region
T1318 2757-2760 NN denotes DNA
T1319 2767-2769 , denotes ,
T1320 2769-2772 CC denotes and
T1321 2773-2777 IN denotes that
T1322 2815-2822 VBN denotes related
T1323 2778-2781 DT denotes the
T1324 2782-2788 NN denotes extent
T1325 2789-2791 IN denotes of
T1326 2792-2800 NN denotes helicase
T1327 2801-2811 NN denotes activation
T1328 2812-2814 VBZ denotes is
T1329 2823-2825 IN denotes to
T1330 2826-2829 DT denotes the
T1331 2838-2845 NN denotes content
T1332 2830-2837 NN denotes thymine
T1333 2846-2848 IN denotes of
T1334 2849-2852 DT denotes the
T1335 2869-2876 NN denotes segment
T1336 2853-2859 JJ denotes single
T1337 2860-2868 VBN denotes stranded
T1338 2859-2860 HYPH denotes -
T1339 2876-2877 . denotes .
T1340 2877-3082 sentence denotes Unexpectedly, Mcm4/6/7 helicase is not capable of efficiently unwinding the GC-rich duplex segment, suggesting that some other mechanism may be required for completion of replication of the entire genome.
T1341 2878-2890 RB denotes Unexpectedly
T1342 2910-2912 VBZ denotes is
T1343 2890-2892 , denotes ,
T1344 2892-2896 NN denotes Mcm4
T1345 2901-2909 NN denotes helicase
T1346 2896-2897 HYPH denotes /
T1347 2897-2898 CD denotes 6
T1348 2898-2899 HYPH denotes /
T1349 2899-2900 CD denotes 7
T1350 2913-2916 RB denotes not
T1351 2917-2924 JJ denotes capable
T1352 2925-2927 IN denotes of
T1353 2928-2939 RB denotes efficiently
T1354 2940-2949 VBG denotes unwinding
T1355 2950-2953 DT denotes the
T1356 2969-2976 NN denotes segment
T1357 2954-2956 NN denotes GC
T1358 2957-2961 JJ denotes rich
T1359 2956-2957 HYPH denotes -
T1360 2962-2968 NN denotes duplex
T1361 2976-2978 , denotes ,
T1362 2978-2988 VBG denotes suggesting
T1363 2989-2993 IN denotes that
T1364 3022-3030 VBN denotes required
T1365 2994-2998 DT denotes some
T1366 3005-3014 NN denotes mechanism
T1367 2999-3004 JJ denotes other
T1368 3015-3018 MD denotes may
T1369 3019-3021 VB denotes be
T1370 3031-3034 IN denotes for
T1371 3035-3045 NN denotes completion
T1372 3046-3048 IN denotes of
T1373 3049-3060 NN denotes replication
T1374 3061-3063 IN denotes of
T1375 3064-3067 DT denotes the
T1376 3075-3081 NN denotes genome
T1377 3068-3074 JJ denotes entire
T1378 3081-3082 . denotes .
R278 T757 T758 compound DNA,helicases
R279 T758 T759 nsubj helicases,couple
R280 T760 T761 det the,hydrolysis
R281 T761 T759 dobj hydrolysis,couple
R282 T762 T761 prep of,hydrolysis
R283 T763 T764 nmod nucleotide,triphosphate
R284 T764 T762 pobj triphosphate,of
R285 T765 T763 cc or,nucleotide
R286 T766 T763 conj deoxynucleotide,nucleotide
R287 T767 T759 prep to,couple
R288 T768 T769 compound duplex,unwinding
R289 T769 T767 pobj unwinding,to
R290 T770 T771 punct (,1
R291 T771 T759 parataxis 1,couple
R292 T772 T771 punct ),1
R293 T773 T759 punct .,couple
R294 T775 T776 nsubjpass Coordination,required
R295 T777 T775 prep of,Coordination
R296 T778 T779 det a,set
R297 T779 T777 pobj set,of
R298 T780 T779 prep of,set
R299 T781 T780 pobj subactivities,of
R300 T782 T781 prep including,subactivities
R301 T783 T784 compound nucleotide,binding
R302 T784 T782 pobj binding,including
R303 T785 T784 punct ", ",binding
R304 T786 T787 compound DNA,binding
R305 T787 T784 conj binding,binding
R306 T788 T787 cc and,binding
R307 T789 T790 compound ATP,hydrolysis
R308 T790 T787 conj hydrolysis,binding
R309 T791 T776 auxpass is,required
R310 T792 T776 prep for,required
R311 T793 T792 pobj unwinding,for
R312 T794 T793 prep of,unwinding
R313 T795 T796 compound duplex,DNA
R314 T796 T794 pobj DNA,of
R315 T797 T798 punct (,2
R316 T798 T776 parataxis 2,required
R317 T799 T798 nummod 1,2
R318 T800 T798 punct ",",2
R319 T801 T798 punct ),2
R320 T802 T776 punct .,required
R321 T804 T805 det The,helicases
R322 T805 T807 nsubjpass helicases,known
R323 T806 T805 amod hexameric,helicases
R324 T808 T805 punct ", ",helicases
R325 T809 T810 prep to,belongs
R326 T810 T805 relcl belongs,helicases
R327 T811 T809 pobj which,to
R328 T812 T813 nmod minichromosome,maintenance
R329 T813 T814 nmod maintenance,helicase
R330 T814 T810 nsubj helicase,belongs
R331 T815 T813 punct (,maintenance
R332 T816 T813 appos Mcm,maintenance
R333 T817 T813 punct ),maintenance
R334 T818 T807 punct ", ",known
R335 T819 T807 auxpass are,known
R336 T820 T821 aux to,assemble
R337 T821 T807 xcomp assemble,known
R338 T822 T823 det a,structure
R339 T823 T821 dobj structure,assemble
R340 T824 T825 npadvmod ring,like
R341 T825 T823 amod like,structure
R342 T826 T825 punct -,like
R343 T827 T828 punct (,3
R344 T828 T807 parataxis 3,known
R345 T829 T830 punct –,5
R346 T830 T828 prep 5,3
R347 T831 T828 punct ),3
R348 T832 T807 punct .,known
R349 T834 T835 mark Whereas,composed
R350 T835 T874 advcl composed,composed
R351 T836 T835 nsubjpass most,composed
R352 T837 T836 prep of,most
R353 T838 T839 compound DNA,helicases
R354 T839 T837 pobj helicases,of
R355 T840 T839 prep of,helicases
R356 T841 T842 det this,group
R357 T842 T840 pobj group,of
R358 T843 T836 punct ", ",most
R359 T844 T836 prep including,most
R360 T845 T846 amod simian,virus
R361 T846 T847 nmod virus,antigen
R362 T847 T844 pobj antigen,including
R363 T848 T846 nummod 40,virus
R364 T849 T847 amod large,antigen
R365 T850 T847 compound T,antigen
R366 T851 T847 punct -,antigen
R367 T852 T853 punct (,6
R368 T853 T847 parataxis 6,antigen
R369 T854 T853 punct ),6
R370 T855 T847 punct ", ",antigen
R371 T856 T857 compound Escherichia,coli
R372 T857 T858 compound coli,DnaB
R373 T858 T847 conj DnaB,antigen
R374 T859 T860 punct (,7
R375 T860 T858 parataxis 7,DnaB
R376 T861 T860 punct ),7
R377 T862 T858 cc and,DnaB
R378 T863 T864 amod Archaeal,Mcm
R379 T864 T858 conj Mcm,DnaB
R380 T865 T866 punct (,9
R381 T866 T864 parataxis 9,Mcm
R382 T867 T866 nummod 4,9
R383 T868 T866 punct ",",9
R384 T869 T866 nummod 8,9
R385 T870 T866 punct ",",9
R386 T871 T866 punct ),9
R387 T872 T835 punct ", ",composed
R388 T873 T835 auxpass are,composed
R389 T875 T835 prep of,composed
R390 T876 T877 det a,subunit
R391 T877 T875 pobj subunit,of
R392 T878 T877 amod single,subunit
R393 T879 T874 punct ", ",composed
R394 T880 T881 det the,helicases
R395 T881 T874 nsubjpass helicases,composed
R396 T882 T881 amod active,helicases
R397 T883 T881 amod eukaryotic,helicases
R398 T884 T881 compound Mcm,helicases
R399 T885 T874 auxpass are,composed
R400 T886 T874 prep of,composed
R401 T887 T888 nummod two,proteins
R403 T889 T888 amod trimeric,proteins
R404 T890 T888 nmod Mcm4,proteins
R405 T891 T890 punct /,Mcm4
R406 T892 T890 nummod 6,Mcm4
R407 T893 T890 punct /,Mcm4
R408 T894 T890 nummod 7,Mcm4
R409 T895 T896 punct (,10
R410 T896 T874 parataxis 10,composed
R411 T897 T898 punct –,14
R412 T898 T896 prep 14,10
R413 T899 T896 punct ),10
R414 T900 T874 punct .,composed
R415 T902 T903 predet All,proteins
R417 T904 T903 det the,proteins
R418 T905 T903 nummod six,proteins
R419 T906 T907 nmod Mcm,2
R420 T907 T903 nummod 2,proteins
R421 T908 T909 punct –,7
R422 T909 T907 prep 7,2
R423 T911 T912 advmod highly,conserved
R424 T912 T913 amod conserved,motifs
R425 T913 T910 dobj motifs,contain
R426 T914 T915 npadvmod DNA,dependent
R427 T915 T913 amod dependent,motifs
R428 T916 T915 punct -,dependent
R429 T917 T913 compound ATPase,motifs
R430 T918 T910 prep in,contain
R431 T919 T920 poss their,regions
R432 T920 T918 pobj regions,in
R433 T921 T920 amod central,regions
R434 T922 T923 punct (,16
R435 T923 T910 parataxis 16,contain
R436 T924 T923 nummod 15,16
R437 T925 T923 punct ",",16
R438 T926 T923 punct ),16
R439 T927 T910 punct .,contain
R440 T929 T930 prep Among,shown
R441 T931 T932 det the,subcomplexes
R442 T932 T929 pobj subcomplexes,Among
R443 T933 T932 amod several,subcomplexes
R444 T934 T932 amod stable,subcomplexes
R445 T935 T936 dep which,generate
R446 T936 T932 relcl generate,subcomplexes
R447 T937 T938 compound MCM,proteins
R448 T938 T936 nsubj proteins,generate
R449 T939 T936 aux can,generate
R450 T940 T930 punct ", ",shown
R451 T941 T942 advmod only,complex
R453 T943 T942 det the,complex
R454 T944 T942 nmod Mcm4,complex
R455 T945 T944 punct /,Mcm4
R456 T946 T944 nummod 6,Mcm4
R457 T947 T944 punct /,Mcm4
R458 T948 T944 nummod 7,Mcm4
R459 T949 T930 aux has,shown
R460 T950 T930 auxpass been,shown
R461 T951 T952 aux to,possess
R462 T952 T930 xcomp possess,shown
R463 T953 T954 det an,activity
R464 T954 T952 dobj activity,possess
R465 T955 T954 amod intrinsic,activity
R466 T956 T957 compound DNA,helicase
R467 T957 T954 compound helicase,activity
R468 T958 T959 punct (,10
R469 T959 T930 parataxis 10,shown
R470 T960 T961 punct –,14
R471 T961 T959 prep 14,10
R472 T962 T959 punct ",",10
R473 T963 T959 appos 17,10
R474 T964 T965 punct –,18
R475 T965 T963 prep 18,17
R476 T966 T959 punct ),10
R477 T967 T930 punct .,shown
R478 T969 T970 mark While,make
R480 T971 T972 nmod Mcm4,proteins
R481 T972 T970 nsubj proteins,make
R482 T973 T971 punct ", ",Mcm4
R483 T974 T971 conj Mcm6,Mcm4
R484 T975 T974 cc and,Mcm6
R485 T976 T974 conj Mcm7,Mcm6
R486 T978 T979 amod distinct,contribution
R487 T979 T970 dobj contribution,make
R488 T980 T979 prep to,contribution
R489 T981 T982 poss its,activity
R490 T982 T980 pobj activity,to
R491 T983 T982 compound helicase,activity
R492 T984 T985 punct (,11
R493 T985 T970 parataxis 11,make
R494 T986 T987 punct –,13
R495 T987 T985 prep 13,11
R496 T988 T985 punct ),11
R497 T989 T977 punct ", ",inhibit
R498 T990 T977 nsubj Mcm2,inhibit
R499 T991 T990 cc or,Mcm2
R500 T992 T990 conj Mcm3,Mcm2
R501 T993 T992 punct /,Mcm3
R502 T994 T992 nummod 5,Mcm3
R503 T995 T996 det the,activity
R504 T996 T977 dobj activity,inhibit
R505 T997 T996 compound helicase,activity
R506 T998 T996 prep of,activity
R507 T999 T1000 det the,complex
R508 T1000 T998 pobj complex,of
R509 T1001 T1000 nmod Mcm4,complex
R510 T1002 T1001 punct /,Mcm4
R511 T1003 T1001 nummod 6,Mcm4
R512 T1004 T1001 punct /,Mcm4
R513 T1005 T1001 nummod 7,Mcm4
R514 T1006 T977 prep by,inhibit
R515 T1007 T1006 pcomp converting,by
R516 T1008 T1009 poss its,structure
R517 T1009 T1007 dobj structure,converting
R518 T1010 T1009 amod double,structure
R519 T1011 T1009 compound trimer,structure
R520 T1012 T1007 prep into,converting
R521 T1013 T1014 det a,heterotetramer
R522 T1014 T1012 pobj heterotetramer,into
R523 T1015 T1014 cc or,heterotetramer
R524 T1016 T1014 conj heteropentamer,heterotetramer
R525 T1017 T1007 punct ", ",converting
R526 T1018 T1007 advmod respectively,converting
R527 T1019 T1020 punct (,11
R528 T1020 T1007 parataxis 11,converting
R529 T1021 T1020 nummod 3,11
R530 T1022 T1020 punct ",",11
R531 T1023 T1020 punct ),11
R532 T1024 T977 punct .,inhibit
R533 T1026 T1027 compound Chromatin,assays
R534 T1027 T1029 nsubj assays,suggested
R535 T1028 T1027 compound immunoprecipitation,assays
R536 T1030 T1027 cc and,assays
R537 T1031 T1032 amod genetic,characterization
R538 T1032 T1027 conj characterization,assays
R539 T1033 T1027 prep in,assays
R540 T1034 T1035 compound Saccharomyces,cerevisiae
R541 T1035 T1033 pobj cerevisiae,in
R542 T1036 T1029 advmod strongly,suggested
R543 T1037 T1038 mark that,involved
R544 T1038 T1029 ccomp involved,suggested
R545 T1039 T1038 nsubjpass Mcm,involved
R546 T1040 T1038 auxpass is,involved
R547 T1041 T1042 preconj not,in
R548 T1042 T1038 prep in,involved
R549 T1043 T1041 advmod only,not
R550 T1044 T1042 pobj initiation,in
R551 T1045 T1042 cc but,in
R552 T1046 T1045 advmod also,but
R553 T1047 T1042 conj in,in
R554 T1048 T1049 det the,stage
R555 T1049 T1047 pobj stage,in
R556 T1050 T1051 compound DNA,elongation
R557 T1051 T1049 compound elongation,stage
R558 T1052 T1051 compound chain,elongation
R559 T1053 T1038 prep as,involved
R560 T1054 T1055 det a,helicase
R561 T1055 T1053 pobj helicase,as
R562 T1056 T1055 amod replicative,helicase
R563 T1057 T1058 punct (,20
R564 T1058 T1029 parataxis 20,suggested
R565 T1059 T1058 nummod 19,20
R566 T1060 T1058 punct ",",20
R567 T1061 T1058 punct ),20
R568 T1062 T1029 punct .,suggested
R569 T1064 T1065 advcl Consistent,stimulated
R570 T1066 T1064 prep with,Consistent
R571 T1067 T1068 det this,notion
R572 T1068 T1066 pobj notion,with
R573 T1069 T1065 punct ", ",stimulated
R574 T1070 T1071 det the,processivity
R575 T1071 T1065 nsubjpass processivity,stimulated
R576 T1072 T1071 prep of,processivity
R577 T1073 T1074 det the,complexes
R578 T1074 T1072 pobj complexes,of
R579 T1075 T1076 nmod Schizosaccharomyces,pombe
R580 T1076 T1074 nmod pombe,complexes
R581 T1077 T1076 cc and,pombe
R582 T1078 T1079 compound mouse,Mcm4
R583 T1079 T1076 conj Mcm4,pombe
R584 T1080 T1079 punct /,Mcm4
R585 T1081 T1079 nummod 6,Mcm4
R586 T1082 T1079 punct /,Mcm4
R587 T1083 T1079 nummod 7,Mcm4
R588 T1084 T1065 auxpass is,stimulated
R589 T1085 T1065 advmod significantly,stimulated
R590 T1086 T1065 prep on,stimulated
R591 T1087 T1088 amod forked,DNA
R592 T1088 T1089 compound DNA,structures
R593 T1089 T1086 pobj structures,on
R594 T1090 T1065 cc and,stimulated
R595 T1091 T1092 nsubj it,unwind
R596 T1092 T1065 conj unwind,stimulated
R597 T1093 T1092 aux can,unwind
R598 T1094 T1095 compound duplex,DNA
R599 T1095 T1092 dobj DNA,unwind
R600 T1096 T1095 prep of,DNA
R601 T1097 T1098 quantmod 400,500
R602 T1098 T1100 nummod 500,bp
R603 T1099 T1098 punct –,500
R604 T1100 T1096 pobj bp,of
R605 T1101 T1102 punct (,14
R606 T1102 T1092 parataxis 14,unwind
R607 T1103 T1102 nummod 13,14
R608 T1104 T1102 punct ",",14
R609 T1105 T1102 punct ),14
R610 T1106 T1092 punct .,unwind
R611 T1108 T1109 nsubj Mcm4,binds
R612 T1110 T1108 punct /,Mcm4
R613 T1111 T1108 nummod 6,Mcm4
R614 T1112 T1108 punct /,Mcm4
R615 T1113 T1108 nummod 7,Mcm4
R616 T1114 T1109 prep to,binds
R617 T1115 T1116 nmod fork,structures
R618 T1116 T1114 pobj structures,to
R619 T1117 T1115 cc and,fork
R620 T1118 T1115 conj bubble,fork
R621 T1119 T1109 prep in,binds
R622 T1120 T1121 det an,manner
R623 T1121 T1119 pobj manner,in
R624 T1122 T1123 npadvmod ATP,dependent
R625 T1123 T1121 amod dependent,manner
R626 T1124 T1123 punct -,dependent
R627 T1125 T1109 punct ", ",binds
R628 T1126 T1109 cc and,binds
R629 T1127 T1109 conj generates,binds
R630 T1128 T1129 det a,complex
R631 T1129 T1127 dobj complex,generates
R632 T1130 T1131 amod double,hexameric
R633 T1131 T1129 amod hexameric,complex
R634 T1132 T1131 punct -,hexameric
R635 T1133 T1127 punct ", ",generates
R636 T1134 T1135 mark as,shown
R637 T1135 T1127 advcl shown,generates
R638 T1136 T1135 auxpass was,shown
R639 T1137 T1135 prep for,shown
R640 T1138 T1139 compound T,antigen
R641 T1139 T1137 pobj antigen,for
R642 T1140 T1139 punct -,antigen
R643 T1141 T1142 punct (,21
R644 T1142 T1135 parataxis 21,shown
R645 T1143 T1142 nummod 13,21
R646 T1144 T1142 punct ",",21
R647 T1145 T1142 nummod 14,21
R648 T1146 T1142 punct ",",21
R649 T1147 T1142 punct ),21
R650 T1148 T1109 punct .,binds
R651 T1150 T1151 advmod Recently,reported
R652 T1152 T1151 punct ", ",reported
R653 T1153 T1151 nsubj we,reported
R654 T1154 T1155 mark that,activated
R655 T1155 T1151 ccomp activated,reported
R656 T1156 T1157 det the,activities
R657 T1157 T1155 nsubjpass activities,activated
R658 T1158 T1157 nmod helicase,activities
R659 T1159 T1158 cc and,helicase
R660 T1160 T1161 compound ATP,hydrolysis
R661 T1161 T1158 conj hydrolysis,helicase
R662 T1162 T1157 prep of,activities
R663 T1163 T1164 amod mammalian,Mcm4
R664 T1164 T1162 pobj Mcm4,of
R665 T1165 T1164 punct /,Mcm4
R666 T1166 T1164 nummod 6,Mcm4
R667 T1167 T1164 punct /,Mcm4
R668 T1168 T1164 nummod 7,Mcm4
R669 T1169 T1155 auxpass are,activated
R670 T1170 T1155 advmod specifically,activated
R671 T1171 T1155 agent by,activated
R672 T1172 T1173 amod single,stranded
R673 T1173 T1175 amod stranded,DNA
R674 T1174 T1173 punct -,stranded
R675 T1175 T1171 pobj DNA,by
R676 T1176 T1175 acl containing,DNA
R677 T1177 T1176 dobj stretches,containing
R678 T1178 T1177 prep of,stretches
R679 T1179 T1180 compound thymine,residues
R680 T1180 T1178 pobj residues,of
R681 T1181 T1151 cc and,reported
R682 T1182 T1151 conj proposed,reported
R683 T1183 T1184 det a,model
R684 T1184 T1182 dobj model,proposed
R685 T1185 T1184 amod novel,model
R686 T1186 T1187 mark that,play
R687 T1187 T1184 acl play,model
R688 T1188 T1187 nsubj Mcm,play
R689 T1189 T1187 aux may,play
R690 T1190 T1191 det a,role
R691 T1191 T1187 dobj role,play
R692 T1192 T1191 amod crucial,role
R693 T1193 T1187 prep in,play
R694 T1194 T1193 pobj selection,in
R695 T1195 T1194 prep of,selection
R696 T1196 T1197 compound replication,origins
R697 T1197 T1195 pobj origins,of
R698 T1198 T1187 prep in,play
R699 T1199 T1200 amod higher,eukaryotes
R700 T1200 T1198 pobj eukaryotes,in
R701 T1201 T1202 punct (,13
R702 T1202 T1182 parataxis 13,proposed
R703 T1203 T1202 punct ),13
R704 T1204 T1151 punct .,reported
R705 T1206 T1207 prep In,conducted
R706 T1208 T1209 det this,report
R707 T1209 T1206 pobj report,In
R708 T1210 T1207 punct ", ",conducted
R709 T1211 T1207 prep in,conducted
R710 T1212 T1211 pobj order,in
R711 T1213 T1214 aux to,clarify
R712 T1214 T1212 acl clarify,order
R713 T1215 T1216 det the,mode
R714 T1216 T1214 dobj mode,clarify
R715 T1217 T1216 prep of,mode
R716 T1218 T1217 pobj action,of
R717 T1219 T1216 prep of,mode
R718 T1220 T1221 det the,helicase
R719 T1221 T1219 pobj helicase,of
R720 T1222 T1221 compound Mcm,helicase
R721 T1223 T1214 cc and,clarify
R722 T1224 T1214 conj obtain,clarify
R723 T1225 T1224 dobj insight,obtain
R724 T1226 T1225 prep into,insight
R725 T1227 T1228 advmod how,function
R726 T1228 T1226 pcomp function,into
R727 T1229 T1228 nsubj it,function
R728 T1230 T1228 aux may,function
R729 T1231 T1228 prep at,function
R730 T1232 T1233 det the,forks
R731 T1233 T1231 pobj forks,at
R732 T1234 T1233 compound replication,forks
R733 T1235 T1236 advmod in,vivo
R734 T1236 T1228 advmod vivo,function
R735 T1237 T1207 punct ", ",conducted
R736 T1238 T1207 nsubj we,conducted
R737 T1239 T1207 aux have,conducted
R738 T1240 T1241 amod detailed,analyses
R739 T1241 T1207 dobj analyses,conducted
R740 T1242 T1241 prep of,analyses
R741 T1243 T1244 compound helicase,action
R742 T1244 T1242 pobj action,of
R743 T1245 T1244 cc and,action
R744 T1246 T1247 compound DNA,binding
R745 T1247 T1244 conj binding,action
R746 T1248 T1244 prep of,action
R747 T1249 T1250 nmod mouse,helicase
R748 T1250 T1248 pobj helicase,of
R749 T1251 T1250 nmod Mcm4,helicase
R750 T1252 T1251 punct /,Mcm4
R751 T1253 T1251 nummod 6,Mcm4
R752 T1254 T1251 punct /,Mcm4
R753 T1255 T1251 nummod 7,Mcm4
R754 T1256 T1207 advcl using,conducted
R755 T1257 T1258 amod various,DNAs
R756 T1258 T1256 dobj DNAs,using
R757 T1259 T1258 amod forked,DNAs
R758 T1260 T1259 cc and,forked
R759 T1261 T1262 compound bubble,substrate
R760 T1262 T1259 conj substrate,forked
R761 T1263 T1207 punct .,conducted
R762 T1265 T1266 nsubj We,addressed
R763 T1267 T1266 advmod specifically,addressed
R764 T1268 T1269 compound sequence,requirement
R765 T1269 T1266 dobj requirement,addressed
R766 T1270 T1269 prep for,requirement
R767 T1271 T1272 det the,activation
R768 T1272 T1270 pobj activation,for
R769 T1273 T1274 compound Mcm,helicase
R770 T1274 T1272 compound helicase,activation
R771 T1275 T1272 punct ", ",activation
R772 T1276 T1272 conj mode,activation
R773 T1277 T1276 prep of,mode
R774 T1278 T1277 pobj interaction,of
R775 T1279 T1278 prep with,interaction
R776 T1280 T1281 compound DNA,substrates
R777 T1281 T1279 pobj substrates,with
R778 T1282 T1276 cc and,mode
R779 T1283 T1284 mark whether,required
R780 T1284 T1276 conj required,mode
R781 T1285 T1286 det the,sequences
R782 T1286 T1284 nsubjpass sequences,required
R783 T1287 T1286 compound thymine,sequences
R784 T1288 T1284 auxpass are,required
R785 T1289 T1284 prep for,required
R786 T1290 T1291 amod continuous,activation
R787 T1291 T1289 pobj activation,for
R788 T1292 T1291 prep of,activation
R789 T1293 T1294 compound Mcm,helicase
R790 T1294 T1292 pobj helicase,of
R791 T1295 T1284 prep during,required
R792 T1296 T1297 det the,process
R793 T1297 T1295 pobj process,during
R794 T1298 T1297 amod unwinding,process
R795 T1299 T1266 punct .,addressed
R796 T1301 T1302 det The,results
R797 T1302 T1303 nsubj results,indicate
R798 T1304 T1305 mark that,binds
R799 T1305 T1303 advcl binds,indicate
R800 T1306 T1307 amod mammalian,Mcm4
R801 T1307 T1305 nsubj Mcm4,binds
R802 T1308 T1307 punct /,Mcm4
R803 T1309 T1307 nummod 6,Mcm4
R804 T1310 T1307 punct /,Mcm4
R805 T1311 T1307 nummod 7,Mcm4
R806 T1312 T1305 advmod primarily,binds
R807 T1313 T1305 prep to,binds
R808 T1314 T1315 amod single,stranded
R809 T1315 T1317 amod stranded,region
R810 T1316 T1315 punct -,stranded
R811 T1317 T1313 pobj region,to
R812 T1318 T1317 compound DNA,region
R813 T1319 T1305 punct ", ",binds
R814 T1320 T1305 cc and,binds
R815 T1321 T1322 mark that,related
R817 T1323 T1324 det the,extent
R818 T1324 T1322 nsubjpass extent,related
R819 T1325 T1324 prep of,extent
R820 T1326 T1327 compound helicase,activation
R821 T1327 T1325 pobj activation,of
R822 T1328 T1322 auxpass is,related
R823 T1329 T1322 prep to,related
R824 T1330 T1331 det the,content
R825 T1331 T1329 pobj content,to
R826 T1332 T1331 compound thymine,content
R827 T1333 T1331 prep of,content
R828 T1334 T1335 det the,segment
R829 T1335 T1333 pobj segment,of
R830 T1336 T1337 amod single,stranded
R831 T1337 T1335 amod stranded,segment
R832 T1338 T1337 punct -,stranded
R833 T1339 T1303 punct .,indicate
R834 T1341 T1342 advmod Unexpectedly,is
R835 T1343 T1342 punct ", ",is
R836 T1344 T1345 nmod Mcm4,helicase
R837 T1345 T1342 nsubj helicase,is
R838 T1346 T1344 punct /,Mcm4
R839 T1347 T1344 nummod 6,Mcm4
R840 T1348 T1344 punct /,Mcm4
R841 T1349 T1344 nummod 7,Mcm4
R842 T1350 T1342 neg not,is
R843 T1351 T1342 acomp capable,is
R844 T1352 T1351 prep of,capable
R845 T1353 T1354 advmod efficiently,unwinding
R846 T1354 T1352 pcomp unwinding,of
R847 T1355 T1356 det the,segment
R848 T1356 T1354 dobj segment,unwinding
R849 T1357 T1358 npadvmod GC,rich
R850 T1358 T1356 amod rich,segment
R851 T1359 T1358 punct -,rich
R852 T1360 T1356 compound duplex,segment
R853 T1361 T1342 punct ", ",is
R854 T1362 T1342 advcl suggesting,is
R855 T1363 T1364 mark that,required
R856 T1364 T1362 ccomp required,suggesting
R857 T1365 T1366 det some,mechanism
R858 T1366 T1364 nsubjpass mechanism,required
R859 T1367 T1366 amod other,mechanism
R860 T1368 T1364 aux may,required
R861 T1369 T1364 auxpass be,required
R862 T1370 T1364 prep for,required
R863 T1371 T1370 pobj completion,for
R864 T1372 T1371 prep of,completion
R865 T1373 T1372 pobj replication,of
R866 T1374 T1373 prep of,replication
R867 T1375 T1376 det the,genome
R868 T1376 T1374 pobj genome,of
R869 T1377 T1376 amod entire,genome
R870 T1378 T1342 punct .,is
R402 T888 T886 pobj proteins,of
R416 T903 T910 nsubj proteins,contain
R452 T942 T930 nsubjpass complex,shown
R479 T970 T977 advcl make,inhibit
R816 T1322 T1305 conj related,binds

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T623 13-16 CHEBI_SO_EXT:DNA denotes DNA
T624 13-26 GO_EXT:0003678 denotes DNA helicases
T625 38-48 MOP:0000619 denotes hydrolysis
T626 52-62 _FRAGMENT denotes nucleotide
T627 82-94 CHEBI_EXT:nucleotide_triphosphate denotes triphosphate
T628 66-94 CHEBI_EXT:dNTP denotes deoxynucleotide triphosphate
T629 98-114 GO:0032508 denotes duplex unwinding
T630 169-179 CHEBI_SO_EXT:nucleotide denotes nucleotide
T631 180-187 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T632 189-192 CHEBI_SO_EXT:DNA denotes DNA
T633 193-200 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T634 205-208 CHEBI_EXT:ATP denotes ATP
T635 209-219 MOP:0000619 denotes hydrolysis
T636 236-259 GO:0032508 denotes unwinding of duplex DNA
T637 249-259 CHEBI_SO_EXT:double_stranded_DNA denotes duplex DNA
T638 271-280 GO_EXT:hexameric_macromolecular_complex denotes hexameric
T639 281-290 GO_EXT:0004386 denotes helicases
T640 301-327 GO:0042555 denotes minichromosome maintenance
T641 329-332 GO:0042555 denotes Mcm
T642 334-342 GO_EXT:0004386 denotes helicase
T643 419-422 CHEBI_SO_EXT:DNA denotes DNA
T644 419-432 GO_EXT:0003678 denotes DNA helicases
T645 458-473 NCBITaxon:10633 denotes simian virus 40
T646 482-489 CHEBI_EXT:59132 denotes antigen
T647 495-511 NCBITaxon:562 denotes Escherichia coli
T648 512-516 PR_EXT:000022460 denotes DnaB
T649 525-533 NCBITaxon:2157 denotes Archaeal
T650 592-602 NCBITaxon:2759 denotes eukaryotic
T651 603-606 GO:0042555 denotes Mcm
T652 607-616 GO_EXT:0004386 denotes helicases
T653 637-645 GO_EXT:trimeric_macromolecular_complex denotes trimeric
T654 646-650 PR_EXT:000010246 denotes Mcm4
T655 646-654 GO:0097373 denotes Mcm4/6/7
T656 655-663 CHEBI_PR_EXT:protein denotes proteins
T657 685-688 GO:0042555 denotes Mcm
T658 685-690 PR_EXT:000010242 denotes Mcm 2
T659 685-688 _FRAGMENT denotes Mcm
T660 691-692 PR_EXT:000010249 denotes 7
T661 693-701 CHEBI_PR_EXT:protein denotes proteins
T662 717-726 SO_EXT:biological_conservation_process_or_quality denotes conserved
T663 727-730 CHEBI_SO_EXT:DNA denotes DNA
T664 727-747 GO_EXT:0008094 denotes DNA-dependent ATPase
T665 748-754 SO_EXT:sequence_or_structure_motif denotes motifs
T666 817-826 GO:0032991 denotes complexes
T667 833-836 GO:0042555 denotes MCM
T668 837-845 CHEBI_PR_EXT:protein denotes proteins
T669 869-873 PR_EXT:000010246 denotes Mcm4
T670 869-885 GO:0097373 denotes Mcm4/6/7 complex
T671 925-928 CHEBI_SO_EXT:DNA denotes DNA
T672 925-937 GO_EXT:0003678 denotes DNA helicase
T673 968-972 PR_EXT:000010246 denotes Mcm4
T674 974-978 PR_EXT:000010248 denotes Mcm6
T675 983-987 PR_EXT:000010249 denotes Mcm7
T676 988-996 CHEBI_PR_EXT:protein denotes proteins
T677 1031-1039 GO_EXT:0004386 denotes helicase
T678 1058-1062 PR_EXT:000010242 denotes Mcm2
T679 1066-1070 PR_EXT:000010243 denotes Mcm3
T680 1085-1093 GO_EXT:0004386 denotes helicase
T681 1110-1114 PR_EXT:000010246 denotes Mcm4
T682 1110-1126 GO:0097373 denotes Mcm4/6/7 complex
T683 1145-1158 GO_EXT:double_trimer_macromolecular_complex denotes double trimer
T684 1182-1190 GO_EXT:tetrameric_macromolecular_complex denotes tetramer
T685 1200-1208 GO_EXT:pentameric_macromolecular_complex denotes pentamer
T686 1231-1240 GO:0000785 denotes Chromatin
T687 1272-1279 SO_EXT:0000704 denotes genetic
T688 1300-1324 NCBITaxon:4932 denotes Saccharomyces cerevisiae
T689 1349-1352 GO:0042555 denotes Mcm
T690 1404-1407 CHEBI_SO_EXT:DNA denotes DNA
T691 1404-1424 GO:0022616 denotes DNA chain elongation
T692 1436-1447 GO:0006260 denotes replicative
T693 1448-1456 GO_EXT:0004386 denotes helicase
T694 1519-1544 NCBITaxon:4896 denotes Schizosaccharomyces pombe
T695 1549-1554 NCBITaxon:10088 denotes mouse
T696 1555-1559 PR_EXT:000010246 denotes Mcm4
T697 1555-1573 GO:0097373 denotes Mcm4/6/7 complexes
T698 1605-1611 GO:0005657 denotes forked
T699 1612-1615 CHEBI_SO_EXT:DNA denotes DNA
T700 1645-1655 CHEBI_SO_EXT:double_stranded_DNA denotes duplex DNA
T701 1667-1669 SO_EXT:0000028 denotes bp
T702 1679-1683 PR_EXT:000010246 denotes Mcm4
T703 1679-1687 GO:0097373 denotes Mcm4/6/7
T704 1688-1693 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T705 1697-1701 GO:0005657 denotes fork
T706 1730-1733 CHEBI_EXT:ATP denotes ATP
T707 1768-1792 GO_EXT:double_hexameric_macromolecular_complex denotes double-hexameric complex
T708 1813-1820 CHEBI_EXT:59132 denotes antigen
T709 1864-1872 GO_EXT:0004386 denotes helicase
T710 1877-1880 CHEBI_EXT:ATP denotes ATP
T711 1881-1891 MOP:0000619 denotes hydrolysis
T712 1906-1915 NCBITaxon:40674 denotes mammalian
T713 1916-1920 PR_EXT:000010246 denotes Mcm4
T714 1916-1924 GO:0097373 denotes Mcm4/6/7
T715 1955-1974 CHEBI_SO_EXT:single_stranded_DNA denotes single-stranded DNA
T716 1999-2006 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T717 2007-2015 CHEBI_EXT:residue denotes residues
T718 2048-2051 GO:0042555 denotes Mcm
T719 2092-2103 GO:0006260 denotes replication
T720 2092-2111 SO_EXT:0000296 denotes replication origins
T721 2122-2132 NCBITaxon:2759 denotes eukaryotes
T722 2201-2204 GO:0042555 denotes Mcm
T723 2205-2213 GO_EXT:0004386 denotes helicase
T724 2265-2276 GO:0006260 denotes replication
T725 2265-2282 GO:0005657 denotes replication forks
T726 2331-2339 GO_EXT:0004386 denotes helicase
T727 2351-2354 CHEBI_SO_EXT:DNA denotes DNA
T728 2355-2362 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T729 2366-2371 NCBITaxon:10088 denotes mouse
T730 2372-2376 PR_EXT:000010246 denotes Mcm4
T731 2372-2380 GO:0097373 denotes Mcm4/6/7
T732 2381-2389 GO_EXT:0004386 denotes helicase
T733 2404-2410 GO:0005657 denotes forked
T734 2432-2436 CHEBI_SO_EXT:DNA denotes DNAs
T735 2464-2472 SO_EXT:biological_sequence denotes sequence
T736 2493-2496 GO:0042555 denotes Mcm
T737 2497-2505 GO_EXT:0004386 denotes helicase
T738 2543-2546 CHEBI_SO_EXT:DNA denotes DNA
T739 2574-2581 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T740 2582-2591 SO_EXT:biological_sequence denotes sequences
T741 2634-2637 GO:0042555 denotes Mcm
T742 2638-2646 GO_EXT:0004386 denotes helicase
T743 2703-2712 NCBITaxon:40674 denotes mammalian
T744 2713-2717 PR_EXT:000010246 denotes Mcm4
T745 2713-2721 GO:0097373 denotes Mcm4/6/7
T746 2732-2737 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T747 2741-2760 CHEBI_SO_EXT:single_stranded_DNA denotes single-stranded DNA
T748 2792-2800 GO_EXT:0004386 denotes helicase
T749 2830-2837 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T750 2853-2868 SO:0000984 denotes single-stranded
T751 2892-2896 PR_EXT:000010246 denotes Mcm4
T752 2892-2900 GO:0097373 denotes Mcm4/6/7
T753 2901-2909 GO_EXT:0004386 denotes helicase
T754 2962-2968 SO:0000985 denotes duplex
T755 3049-3060 GO:0006260 denotes replication
T756 3075-3081 SO_EXT:0001026 denotes genome
R276 T627 T626 _lexicallyChainedTo triphosphate,nucleotide
R277 T660 T659 _lexicallyChainedTo 7,Mcm

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T547 38-48 MOP:0000619 denotes hydrolysis
T548 98-114 GO:0032508 denotes duplex unwinding
T549 209-219 MOP:0000619 denotes hydrolysis
T550 236-259 GO:0032508 denotes unwinding of duplex DNA
T551 249-255 SO:0000985 denotes duplex
T552 301-327 GO:0042555 denotes minichromosome maintenance
T553 329-332 GO:0042555 denotes Mcm
T554 458-473 NCBITaxon:10633 denotes simian virus 40
T555 482-489 CHEBI:59132 denotes antigen
T556 495-511 NCBITaxon:562 denotes Escherichia coli
T557 512-516 PR:000022460 denotes DnaB
T558 525-533 NCBITaxon:2157 denotes Archaeal
T559 592-602 NCBITaxon:2759 denotes eukaryotic
T560 603-606 GO:0042555 denotes Mcm
T561 646-650 PR:000010246 denotes Mcm4
T562 646-654 GO:0097373 denotes Mcm4/6/7
T563 685-688 GO:0042555 denotes Mcm
T564 685-690 PR:000010242 denotes Mcm 2
T565 685-688 _FRAGMENT denotes Mcm
T566 691-692 PR:000010249 denotes 7
T567 817-826 GO:0032991 denotes complexes
T568 833-836 GO:0042555 denotes MCM
T569 869-873 PR:000010246 denotes Mcm4
T570 869-885 GO:0097373 denotes Mcm4/6/7 complex
T571 968-972 PR:000010246 denotes Mcm4
T572 974-978 PR:000010248 denotes Mcm6
T573 983-987 PR:000010249 denotes Mcm7
T574 1058-1062 PR:000010242 denotes Mcm2
T575 1066-1070 PR:000010243 denotes Mcm3
T576 1110-1114 PR:000010246 denotes Mcm4
T577 1110-1126 GO:0097373 denotes Mcm4/6/7 complex
T578 1231-1240 GO:0000785 denotes Chromatin
T579 1272-1279 SO:0000704 denotes genetic
T580 1300-1324 NCBITaxon:4932 denotes Saccharomyces cerevisiae
T581 1349-1352 GO:0042555 denotes Mcm
T582 1404-1424 GO:0022616 denotes DNA chain elongation
T583 1436-1447 GO:0006260 denotes replicative
T584 1519-1544 NCBITaxon:4896 denotes Schizosaccharomyces pombe
T585 1549-1554 NCBITaxon:10088 denotes mouse
T586 1555-1559 PR:000010246 denotes Mcm4
T587 1555-1573 GO:0097373 denotes Mcm4/6/7 complexes
T588 1605-1611 GO:0005657 denotes forked
T589 1645-1651 SO:0000985 denotes duplex
T590 1667-1669 SO:0000028 denotes bp
T591 1679-1683 PR:000010246 denotes Mcm4
T592 1679-1687 GO:0097373 denotes Mcm4/6/7
T593 1697-1701 GO:0005657 denotes fork
T594 1813-1820 CHEBI:59132 denotes antigen
T595 1881-1891 MOP:0000619 denotes hydrolysis
T596 1906-1915 NCBITaxon:40674 denotes mammalian
T597 1916-1920 PR:000010246 denotes Mcm4
T598 1916-1924 GO:0097373 denotes Mcm4/6/7
T599 1955-1970 SO:0000984 denotes single-stranded
T600 2048-2051 GO:0042555 denotes Mcm
T601 2092-2103 GO:0006260 denotes replication
T602 2092-2111 SO:0000296 denotes replication origins
T603 2122-2132 NCBITaxon:2759 denotes eukaryotes
T604 2201-2204 GO:0042555 denotes Mcm
T605 2265-2276 GO:0006260 denotes replication
T606 2265-2282 GO:0005657 denotes replication forks
T607 2366-2371 NCBITaxon:10088 denotes mouse
T608 2372-2376 PR:000010246 denotes Mcm4
T609 2372-2380 GO:0097373 denotes Mcm4/6/7
T610 2404-2410 GO:0005657 denotes forked
T611 2493-2496 GO:0042555 denotes Mcm
T612 2634-2637 GO:0042555 denotes Mcm
T613 2703-2712 NCBITaxon:40674 denotes mammalian
T614 2713-2717 PR:000010246 denotes Mcm4
T615 2713-2721 GO:0097373 denotes Mcm4/6/7
T616 2741-2756 SO:0000984 denotes single-stranded
T617 2853-2868 SO:0000984 denotes single-stranded
T618 2892-2896 PR:000010246 denotes Mcm4
T619 2892-2900 GO:0097373 denotes Mcm4/6/7
T620 2962-2968 SO:0000985 denotes duplex
T621 3049-3060 GO:0006260 denotes replication
T622 3075-3081 SO:0001026 denotes genome
R275 T566 T565 _lexicallyChainedTo 7,Mcm

2_test

Id Subject Object Predicate Lexical cue
15917436-10966472-76775476 116-117 10966472 denotes 1
15917436-10966472-76775477 261-262 10966472 denotes 1
15917436-8381400-76775478 263-264 8381400 denotes 2
15917436-10884341-76775479 397-398 10884341 denotes 3
15917436-14566326-76775479 397-398 14566326 denotes 3
15917436-12548282-76775479 397-398 12548282 denotes 3
15917436-12774115-76775480 491-492 12774115 denotes 6
15917436-12206765-76775481 518-519 12206765 denotes 7
15917436-14566326-76775482 539-540 14566326 denotes 4
15917436-10611290-76775483 541-542 10611290 denotes 8
15917436-10677495-76775484 543-544 10677495 denotes 9
15917436-9305914-76775485 665-667 9305914 denotes 10
15917436-10567526-76775485 665-667 10567526 denotes 10
15917436-12207017-76775485 665-667 12207017 denotes 10
15917436-14609960-76775485 665-667 14609960 denotes 10
15917436-11136247-76775485 665-667 11136247 denotes 10
15917436-10872463-76775486 781-783 10872463 denotes 15
15917436-12045100-76775487 784-786 12045100 denotes 16
15917436-9305914-76775488 948-950 9305914 denotes 10
15917436-10567526-76775488 948-950 10567526 denotes 10
15917436-12207017-76775488 948-950 12207017 denotes 10
15917436-14609960-76775488 948-950 14609960 denotes 10
15917436-11136247-76775488 948-950 11136247 denotes 10
15917436-9214646-76775489 954-956 9214646 denotes 17
15917436-10770926-76775489 954-956 10770926 denotes 17
15917436-10567526-76775490 1050-1052 10567526 denotes 11
15917436-12207017-76775490 1050-1052 12207017 denotes 11
15917436-14609960-76775490 1050-1052 14609960 denotes 11
15917436-10884341-76775491 1224-1225 10884341 denotes 3
15917436-10567526-76775492 1226-1228 10567526 denotes 11
15917436-9335335-76775493 1458-1460 9335335 denotes 19
15917436-10834843-76775494 1461-1463 10834843 denotes 20
15917436-14609960-76775495 1671-1673 14609960 denotes 13
15917436-11136247-76775496 1674-1676 11136247 denotes 14
15917436-14609960-76775497 1822-1824 14609960 denotes 13
15917436-11136247-76775498 1825-1827 11136247 denotes 14
15917436-9765408-76775499 1828-1830 9765408 denotes 21
15917436-14609960-76775500 2134-2136 14609960 denotes 13