PMC:1140370 / 1311-1585 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1140370","sourcedb":"PMC","sourceid":"1140370","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1140370","text":"n Mcm4/6/7 helicase has difficulties in unwinding stably base-paired duplex. Taken together, these findings reveal important features on activation and substrate preference of the eukaryotic replicative helicase.\n\nINTRODUCTION\nDNA helicases couple the hydrolysis of nucleoti","divisions":[{"label":"title","span":{"begin":214,"end":226}}],"tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T399","span":{"begin":20,"end":23},"obj":"VBZ"},{"id":"T401","span":{"begin":11,"end":19},"obj":"NN"},{"id":"T402","span":{"begin":2,"end":6},"obj":"NN"},{"id":"T403","span":{"begin":6,"end":7},"obj":"HYPH"},{"id":"T404","span":{"begin":7,"end":8},"obj":"CD"},{"id":"T405","span":{"begin":8,"end":9},"obj":"HYPH"},{"id":"T406","span":{"begin":9,"end":10},"obj":"CD"},{"id":"T407","span":{"begin":24,"end":36},"obj":"NNS"},{"id":"T408","span":{"begin":37,"end":39},"obj":"IN"},{"id":"T409","span":{"begin":40,"end":49},"obj":"VBG"},{"id":"T410","span":{"begin":50,"end":56},"obj":"RB"},{"id":"T411","span":{"begin":62,"end":68},"obj":"VBN"},{"id":"T412","span":{"begin":57,"end":61},"obj":"NN"},{"id":"T413","span":{"begin":61,"end":62},"obj":"HYPH"},{"id":"T414","span":{"begin":69,"end":75},"obj":"NN"},{"id":"T415","span":{"begin":75,"end":76},"obj":"."},{"id":"T416","span":{"begin":76,"end":212},"obj":"sentence"},{"id":"T417","span":{"begin":77,"end":82},"obj":"VBN"},{"id":"T418","span":{"begin":108,"end":114},"obj":"VBP"},{"id":"T419","span":{"begin":83,"end":91},"obj":"RB"},{"id":"T420","span":{"begin":91,"end":93},"obj":","},{"id":"T421","span":{"begin":93,"end":98},"obj":"DT"},{"id":"T422","span":{"begin":99,"end":107},"obj":"NNS"},{"id":"T423","span":{"begin":115,"end":124},"obj":"JJ"},{"id":"T424","span":{"begin":125,"end":133},"obj":"NNS"},{"id":"T425","span":{"begin":134,"end":136},"obj":"IN"},{"id":"T426","span":{"begin":137,"end":147},"obj":"NN"},{"id":"T427","span":{"begin":162,"end":172},"obj":"NN"},{"id":"T428","span":{"begin":148,"end":151},"obj":"CC"},{"id":"T429","span":{"begin":152,"end":161},"obj":"NN"},{"id":"T430","span":{"begin":173,"end":175},"obj":"IN"},{"id":"T431","span":{"begin":176,"end":179},"obj":"DT"},{"id":"T432","span":{"begin":203,"end":211},"obj":"NN"},{"id":"T433","span":{"begin":180,"end":190},"obj":"JJ"},{"id":"T434","span":{"begin":191,"end":202},"obj":"JJ"},{"id":"T435","span":{"begin":211,"end":212},"obj":"."},{"id":"T757","span":{"begin":227,"end":230},"obj":"NN"},{"id":"T758","span":{"begin":231,"end":240},"obj":"NNS"},{"id":"T759","span":{"begin":241,"end":247},"obj":"VBP"},{"id":"T760","span":{"begin":248,"end":251},"obj":"DT"},{"id":"T761","span":{"begin":252,"end":262},"obj":"NN"},{"id":"T762","span":{"begin":263,"end":265},"obj":"IN"}],"relations":[{"id":"R214","pred":"nsubj","subj":"T401","obj":"T399"},{"id":"R216","pred":"nmod","subj":"T402","obj":"T401"},{"id":"R217","pred":"punct","subj":"T403","obj":"T402"},{"id":"R219","pred":"nummod","subj":"T404","obj":"T402"},{"id":"R220","pred":"punct","subj":"T405","obj":"T402"},{"id":"R221","pred":"nummod","subj":"T406","obj":"T402"},{"id":"R223","pred":"dobj","subj":"T407","obj":"T399"},{"id":"R224","pred":"prep","subj":"T408","obj":"T407"},{"id":"R226","pred":"pcomp","subj":"T409","obj":"T408"},{"id":"R228","pred":"advmod","subj":"T410","obj":"T411"},{"id":"R229","pred":"amod","subj":"T411","obj":"T414"},{"id":"R230","pred":"npadvmod","subj":"T412","obj":"T411"},{"id":"R232","pred":"punct","subj":"T413","obj":"T411"},{"id":"R233","pred":"dobj","subj":"T414","obj":"T409"},{"id":"R238","pred":"advcl","subj":"T417","obj":"T418"},{"id":"R240","pred":"advmod","subj":"T419","obj":"T417"},{"id":"R243","pred":"punct","subj":"T420","obj":"T418"},{"id":"R244","pred":"det","subj":"T421","obj":"T422"},{"id":"R246","pred":"nsubj","subj":"T422","obj":"T418"},{"id":"R247","pred":"amod","subj":"T423","obj":"T424"},{"id":"R248","pred":"dobj","subj":"T424","obj":"T418"},{"id":"R250","pred":"prep","subj":"T425","obj":"T424"},{"id":"R252","pred":"nmod","subj":"T426","obj":"T427"},{"id":"R253","pred":"pobj","subj":"T427","obj":"T425"},{"id":"R254","pred":"cc","subj":"T428","obj":"T426"},{"id":"R256","pred":"conj","subj":"T429","obj":"T426"},{"id":"R257","pred":"prep","subj":"T430","obj":"T427"},{"id":"R259","pred":"det","subj":"T431","obj":"T432"},{"id":"R260","pred":"pobj","subj":"T432","obj":"T430"},{"id":"R262","pred":"amod","subj":"T433","obj":"T432"},{"id":"R263","pred":"amod","subj":"T434","obj":"T432"},{"id":"R264","pred":"punct","subj":"T435","obj":"T418"},{"id":"R278","pred":"compound","subj":"T757","obj":"T758"},{"id":"R279","pred":"nsubj","subj":"T758","obj":"T759"},{"id":"R280","pred":"det","subj":"T760","obj":"T761"},{"id":"R281","pred":"dobj","subj":"T761","obj":"T759"},{"id":"R282","pred":"prep","subj":"T762","obj":"T761"}],"attributes":[{"subj":"T399","pred":"source","obj":"craft-sa-dev"},{"subj":"T401","pred":"source","obj":"craft-sa-dev"},{"subj":"T402","pred":"source","obj":"craft-sa-dev"},{"subj":"T403","pred":"source","obj":"craft-sa-dev"},{"subj":"T404","pred":"source","obj":"craft-sa-dev"},{"subj":"T405","pred":"source","obj":"craft-sa-dev"},{"subj":"T406","pred":"source","obj":"craft-sa-dev"},{"subj":"T407","pred":"source","obj":"craft-sa-dev"},{"subj":"T408","pred":"source","obj":"craft-sa-dev"},{"subj":"T409","pred":"source","obj":"craft-sa-dev"},{"subj":"T410","pred":"source","obj":"craft-sa-dev"},{"subj":"T411","pred":"source","obj":"craft-sa-dev"},{"subj":"T412","pred":"source","obj":"craft-sa-dev"},{"subj":"T413","pred":"source","obj":"craft-sa-dev"},{"subj":"T414","pred":"source","obj":"craft-sa-dev"},{"subj":"T415","pred":"source","obj":"craft-sa-dev"},{"subj":"T416","pred":"source","obj":"craft-sa-dev"},{"subj":"T417","pred":"source","obj":"craft-sa-dev"},{"subj":"T418","pred":"source","obj":"craft-sa-dev"},{"subj":"T419","pred":"source","obj":"craft-sa-dev"},{"subj":"T420","pred":"source","obj":"craft-sa-dev"},{"subj":"T421","pred":"source","obj":"craft-sa-dev"},{"subj":"T422","pred":"source","obj":"craft-sa-dev"},{"subj":"T423","pred":"source","obj":"craft-sa-dev"},{"subj":"T424","pred":"source","obj":"craft-sa-dev"},{"subj":"T425","pred":"source","obj":"craft-sa-dev"},{"subj":"T426","pred":"source","obj":"craft-sa-dev"},{"subj":"T427","pred":"source","obj":"craft-sa-dev"},{"subj":"T428","pred":"source","obj":"craft-sa-dev"},{"subj":"T429","pred":"source","obj":"craft-sa-dev"},{"subj":"T430","pred":"source","obj":"craft-sa-dev"},{"subj":"T431","pred":"source","obj":"craft-sa-dev"},{"subj":"T432","pred":"source","obj":"craft-sa-dev"},{"subj":"T433","pred":"source","obj":"craft-sa-dev"},{"subj":"T434","pred":"source","obj":"craft-sa-dev"},{"subj":"T435","pred":"source","obj":"craft-sa-dev"},{"subj":"T757","pred":"source","obj":"craft-sa-dev"},{"subj":"T758","pred":"source","obj":"craft-sa-dev"},{"subj":"T759","pred":"source","obj":"craft-sa-dev"},{"subj":"T760","pred":"source","obj":"craft-sa-dev"},{"subj":"T761","pred":"source","obj":"craft-sa-dev"},{"subj":"T762","pred":"source","obj":"craft-sa-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T134","span":{"begin":2,"end":6},"obj":"PR_EXT:000010246"},{"id":"T135","span":{"begin":2,"end":10},"obj":"GO:0097373"},{"id":"T136","span":{"begin":11,"end":19},"obj":"GO_EXT:0004386"},{"id":"T137","span":{"begin":57,"end":61},"obj":"CHEBI_SO_EXT:base"},{"id":"T138","span":{"begin":57,"end":68},"obj":"SO_EXT:0000028"},{"id":"T139","span":{"begin":180,"end":190},"obj":"NCBITaxon:2759"},{"id":"T140","span":{"begin":191,"end":202},"obj":"GO:0006260"},{"id":"T141","span":{"begin":203,"end":211},"obj":"GO_EXT:0004386"},{"id":"T623","span":{"begin":227,"end":230},"obj":"CHEBI_SO_EXT:DNA"},{"id":"T624","span":{"begin":227,"end":240},"obj":"GO_EXT:0003678"},{"id":"T625","span":{"begin":252,"end":262},"obj":"MOP:0000619"}],"attributes":[{"subj":"T134","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T135","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T136","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T137","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T138","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T139","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T140","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T141","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T623","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T624","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T625","pred":"source","obj":"craft-ca-core-ex-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T78","span":{"begin":2,"end":6},"obj":"PR:000010246"},{"id":"T79","span":{"begin":2,"end":10},"obj":"GO:0097373"},{"id":"T80","span":{"begin":57,"end":68},"obj":"SO:0000028"},{"id":"T81","span":{"begin":180,"end":190},"obj":"NCBITaxon:2759"},{"id":"T82","span":{"begin":191,"end":202},"obj":"GO:0006260"},{"id":"T547","span":{"begin":252,"end":262},"obj":"MOP:0000619"}],"attributes":[{"subj":"T78","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T79","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T80","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T81","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T82","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T547","pred":"source","obj":"craft-ca-core-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#caec93","default":true},{"id":"craft-ca-core-ex-dev","color":"#ec93e4"},{"id":"craft-ca-core-dev","color":"#93ecd9"}]}]}}