PMC:1134661 / 9902-11026 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1134661","sourcedb":"PMC","sourceid":"1134661","source_url":"https://www.ncbi.nlm.nih.gov/pmc/1134661","text":"A subset of experiments was performed during local perfusion of the NA transporter (NAT) blocker desipramine (DMI, 100 μM) into the mPFC and Occ. After at least 2 h of perfusion, extracellular NA and DA levels had increased stably, to 15.16 ± 1.93 and 8.27 ± 1.23 in the mPFC (n = 7), and to 19.60 ± 3,49 and 10.10 ± 3.53 pg/sample (n = 5) in the Occ, for NA and DA respectively. Multiple electrical stimulation of the LC further increased extracellular NA and DA levels, although in this condition not only DA but also NA failed to return to baseline during stimulation intervals, accumulating a significant increase of about 20% in the mPFC and 50% in the Occ (fig 8) (ANOVA results: mPFC, NA: F(12,48) = 20.743, P \u003c 0.0001, DA: F(12,48) = 2.418, P = 0.0152; Occ, NA: F(12,48) = 21.852, P \u003c 0.0001, DA: F(12,48) = 10.021, P \u003c 0.0001). In the mPFC, each stimulated NA level was significantly different from the subsequent interval sample, while no significance was found in the Occ between stimulated and pause NA levels, as well as for DA levels in either the mPFC or Occ (P \u003c 0.05, Tukey-Kramer multiple comparison test).","tracks":[]}