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To further elucidate the role of BMPs in human B cells, we performed western blot analysis for type I and type II BMP receptors. This analysis revealed that the type I receptors Act-RIA, BMP-RIB and the type II receptors BMP-RII and Act-RIIb are expressed on resting human B-cells (Figure 4). Ramos cells expressed the type I receptors Act-RIA, weakly BMP-RIB and the type II receptor BMP-RII, but more weakly than normal B cells (Figure 4). HL60 cells were used for comparison and weakly expressed Act-RIA and BMP-RII.\nTaken together, these data show that normal human B cells and Ramos cells express a set of BMP receptors, previously shown to bind BMP-6 [16]."}

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{"project":"GO-CC","denotations":[{"id":"T4417","span":{"begin":8,"end":13},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T4418","span":{"begin":110,"end":115},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T4419","span":{"begin":193,"end":198},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T4420","span":{"begin":419,"end":424},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T4421","span":{"begin":443,"end":448},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T4422","span":{"begin":568,"end":573},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T4423","span":{"begin":591,"end":596},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T4424","span":{"begin":716,"end":721},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T4425","span":{"begin":732,"end":737},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Human B cells express BMP-6 receptors\nDetailed knowledge regarding expression of different BMP receptors in B cells is currently not available. To further elucidate the role of BMPs in human B cells, we performed western blot analysis for type I and type II BMP receptors. This analysis revealed that the type I receptors Act-RIA, BMP-RIB and the type II receptors BMP-RII and Act-RIIb are expressed on resting human B-cells (Figure 4). Ramos cells expressed the type I receptors Act-RIA, weakly BMP-RIB and the type II receptor BMP-RII, but more weakly than normal B cells (Figure 4). HL60 cells were used for comparison and weakly expressed Act-RIA and BMP-RII.\nTaken together, these data show that normal human B cells and Ramos cells express a set of BMP receptors, previously shown to bind BMP-6 [16]."}

{"project":"sentences","denotations":[{"id":"T4052","span":{"begin":0,"end":37},"obj":"Sentence"},{"id":"T4053","span":{"begin":38,"end":143},"obj":"Sentence"},{"id":"T4054","span":{"begin":144,"end":272},"obj":"Sentence"},{"id":"T4055","span":{"begin":273,"end":436},"obj":"Sentence"},{"id":"T4056","span":{"begin":437,"end":585},"obj":"Sentence"},{"id":"T4057","span":{"begin":586,"end":663},"obj":"Sentence"},{"id":"T4058","span":{"begin":664,"end":806},"obj":"Sentence"},{"id":"T53","span":{"begin":0,"end":37},"obj":"Sentence"},{"id":"T54","span":{"begin":38,"end":143},"obj":"Sentence"},{"id":"T55","span":{"begin":144,"end":272},"obj":"Sentence"},{"id":"T56","span":{"begin":273,"end":436},"obj":"Sentence"},{"id":"T57","span":{"begin":437,"end":585},"obj":"Sentence"},{"id":"T58","span":{"begin":586,"end":663},"obj":"Sentence"},{"id":"T59","span":{"begin":664,"end":806},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Human B cells express BMP-6 receptors\nDetailed knowledge regarding expression of different BMP receptors in B cells is currently not available. To further elucidate the role of BMPs in human B cells, we performed western blot analysis for type I and type II BMP receptors. This analysis revealed that the type I receptors Act-RIA, BMP-RIB and the type II receptors BMP-RII and Act-RIIb are expressed on resting human B-cells (Figure 4). Ramos cells expressed the type I receptors Act-RIA, weakly BMP-RIB and the type II receptor BMP-RII, but more weakly than normal B cells (Figure 4). HL60 cells were used for comparison and weakly expressed Act-RIA and BMP-RII.\nTaken together, these data show that normal human B cells and Ramos cells express a set of BMP receptors, previously shown to bind BMP-6 [16]."}

{"project":"events-check-again","denotations":[{"id":"T4471","span":{"begin":22,"end":27},"obj":"Protein"},{"id":"T4472","span":{"begin":322,"end":329},"obj":"Protein"},{"id":"T4473","span":{"begin":331,"end":338},"obj":"Protein"},{"id":"T4474","span":{"begin":365,"end":372},"obj":"Protein"},{"id":"T4475","span":{"begin":377,"end":385},"obj":"Protein"},{"id":"T4476","span":{"begin":390,"end":399},"obj":"Gene_expression"},{"id":"T4477","span":{"begin":390,"end":399},"obj":"Gene_expression"},{"id":"T4478","span":{"begin":390,"end":399},"obj":"Gene_expression"},{"id":"T4479","span":{"begin":390,"end":399},"obj":"Gene_expression"},{"id":"T4480","span":{"begin":449,"end":458},"obj":"Gene_expression"},{"id":"T4481","span":{"begin":449,"end":458},"obj":"Gene_expression"},{"id":"T4482","span":{"begin":449,"end":458},"obj":"Gene_expression"},{"id":"T4483","span":{"begin":480,"end":487},"obj":"Protein"},{"id":"T4484","span":{"begin":496,"end":503},"obj":"Protein"},{"id":"T4485","span":{"begin":529,"end":536},"obj":"Protein"},{"id":"T4486","span":{"begin":633,"end":642},"obj":"Gene_expression"},{"id":"T4487","span":{"begin":633,"end":642},"obj":"Gene_expression"},{"id":"T4488","span":{"begin":643,"end":650},"obj":"Protein"},{"id":"T4489","span":{"begin":655,"end":662},"obj":"Protein"},{"id":"T4490","span":{"begin":790,"end":794},"obj":"Binding"},{"id":"T4491","span":{"begin":795,"end":800},"obj":"Protein"}],"relations":[{"id":"R3468","pred":"themeOf","subj":"T4472","obj":"T4479"},{"id":"R3469","pred":"themeOf","subj":"T4473","obj":"T4478"},{"id":"R3470","pred":"themeOf","subj":"T4474","obj":"T4477"},{"id":"R3471","pred":"themeOf","subj":"T4475","obj":"T4476"},{"id":"R3472","pred":"themeOf","subj":"T4483","obj":"T4481"},{"id":"R3473","pred":"themeOf","subj":"T4484","obj":"T4482"},{"id":"R3474","pred":"themeOf","subj":"T4485","obj":"T4480"},{"id":"R3475","pred":"themeOf","subj":"T4488","obj":"T4487"},{"id":"R3476","pred":"themeOf","subj":"T4489","obj":"T4486"},{"id":"R3477","pred":"themeOf","subj":"T4491","obj":"T4490"}],"text":"Human B cells express BMP-6 receptors\nDetailed knowledge regarding expression of different BMP receptors in B cells is currently not available. To further elucidate the role of BMPs in human B cells, we performed western blot analysis for type I and type II BMP receptors. This analysis revealed that the type I receptors Act-RIA, BMP-RIB and the type II receptors BMP-RII and Act-RIIb are expressed on resting human B-cells (Figure 4). Ramos cells expressed the type I receptors Act-RIA, weakly BMP-RIB and the type II receptor BMP-RII, but more weakly than normal B cells (Figure 4). HL60 cells were used for comparison and weakly expressed Act-RIA and BMP-RII.\nTaken together, these data show that normal human B cells and Ramos cells express a set of BMP receptors, previously shown to bind BMP-6 [16]."}

{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T4426","span":{"begin":0,"end":7},"obj":"Protein"},{"id":"T4427","span":{"begin":14,"end":21},"obj":"Gene_expression"},{"id":"T4428","span":{"begin":22,"end":37},"obj":"Protein"},{"id":"T4429","span":{"begin":67,"end":77},"obj":"Gene_expression"},{"id":"T4430","span":{"begin":91,"end":104},"obj":"Protein"},{"id":"T4431","span":{"begin":177,"end":181},"obj":"Protein"},{"id":"T4432","span":{"begin":255,"end":271},"obj":"Protein"},{"id":"T4433","span":{"begin":305,"end":321},"obj":"Protein"},{"id":"T4434","span":{"begin":347,"end":372},"obj":"Protein"},{"id":"T4435","span":{"begin":377,"end":385},"obj":"Protein"},{"id":"T4436","span":{"begin":390,"end":399},"obj":"Gene_expression"},{"id":"T4437","span":{"begin":390,"end":399},"obj":"Gene_expression"},{"id":"T4438","span":{"begin":390,"end":399},"obj":"Gene_expression"},{"id":"T4439","span":{"begin":449,"end":458},"obj":"Gene_expression"},{"id":"T4440","span":{"begin":449,"end":458},"obj":"Gene_expression"},{"id":"T4441","span":{"begin":463,"end":479},"obj":"Protein"},{"id":"T4442","span":{"begin":512,"end":536},"obj":"Protein"},{"id":"T4443","span":{"begin":633,"end":642},"obj":"Gene_expression"},{"id":"T4444","span":{"begin":633,"end":642},"obj":"Gene_expression"},{"id":"T4445","span":{"begin":643,"end":650},"obj":"Protein"},{"id":"T4446","span":{"begin":655,"end":662},"obj":"Protein"},{"id":"T4447","span":{"begin":738,"end":745},"obj":"Gene_expression"},{"id":"T4448","span":{"begin":755,"end":768},"obj":"Protein"},{"id":"T4449","span":{"begin":790,"end":794},"obj":"Binding"}],"relations":[{"id":"R3447","pred":"themeOf","subj":"T4428","obj":"T4427"},{"id":"R3448","pred":"themeOf","subj":"T4430","obj":"T4429"},{"id":"R3449","pred":"themeOf","subj":"T4433","obj":"T4436"},{"id":"R3450","pred":"themeOf","subj":"T4434","obj":"T4437"},{"id":"R3451","pred":"themeOf","subj":"T4435","obj":"T4438"},{"id":"R3452","pred":"themeOf","subj":"T4441","obj":"T4439"},{"id":"R3453","pred":"themeOf","subj":"T4442","obj":"T4440"},{"id":"R3454","pred":"themeOf","subj":"T4445","obj":"T4443"},{"id":"R3455","pred":"themeOf","subj":"T4446","obj":"T4444"},{"id":"R3456","pred":"themeOf","subj":"T4448","obj":"T4447"},{"id":"R3457","pred":"themeOf","subj":"T4448","obj":"T4449"}],"text":"Human B cells express BMP-6 receptors\nDetailed knowledge regarding expression of different BMP receptors in B cells is currently not available. To further elucidate the role of BMPs in human B cells, we performed western blot analysis for type I and type II BMP receptors. This analysis revealed that the type I receptors Act-RIA, BMP-RIB and the type II receptors BMP-RII and Act-RIIb are expressed on resting human B-cells (Figure 4). Ramos cells expressed the type I receptors Act-RIA, weakly BMP-RIB and the type II receptor BMP-RII, but more weakly than normal B cells (Figure 4). HL60 cells were used for comparison and weakly expressed Act-RIA and BMP-RII.\nTaken together, these data show that normal human B cells and Ramos cells express a set of BMP receptors, previously shown to bind BMP-6 [16]."}

{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T4031","span":{"begin":22,"end":27},"obj":"Protein"},{"id":"T4032","span":{"begin":322,"end":329},"obj":"Protein"},{"id":"T4033","span":{"begin":331,"end":338},"obj":"Protein"},{"id":"T4034","span":{"begin":365,"end":372},"obj":"Protein"},{"id":"T4035","span":{"begin":377,"end":385},"obj":"Protein"},{"id":"T4036","span":{"begin":390,"end":399},"obj":"Gene_expression"},{"id":"T4037","span":{"begin":390,"end":399},"obj":"Gene_expression"},{"id":"T4038","span":{"begin":390,"end":399},"obj":"Gene_expression"},{"id":"T4039","span":{"begin":390,"end":399},"obj":"Gene_expression"},{"id":"T4040","span":{"begin":449,"end":458},"obj":"Gene_expression"},{"id":"T4041","span":{"begin":449,"end":458},"obj":"Gene_expression"},{"id":"T4042","span":{"begin":449,"end":458},"obj":"Gene_expression"},{"id":"T4043","span":{"begin":480,"end":487},"obj":"Protein"},{"id":"T4044","span":{"begin":496,"end":503},"obj":"Protein"},{"id":"T4045","span":{"begin":529,"end":536},"obj":"Protein"},{"id":"T4046","span":{"begin":633,"end":642},"obj":"Gene_expression"},{"id":"T4047","span":{"begin":633,"end":642},"obj":"Gene_expression"},{"id":"T4048","span":{"begin":643,"end":650},"obj":"Protein"},{"id":"T4049","span":{"begin":655,"end":662},"obj":"Protein"},{"id":"T4050","span":{"begin":790,"end":794},"obj":"Binding"},{"id":"T4051","span":{"begin":795,"end":800},"obj":"Protein"}],"relations":[{"id":"R3141","pred":"themeOf","subj":"T4032","obj":"T4039"},{"id":"R3142","pred":"themeOf","subj":"T4033","obj":"T4038"},{"id":"R3143","pred":"themeOf","subj":"T4034","obj":"T4037"},{"id":"R3144","pred":"themeOf","subj":"T4035","obj":"T4036"},{"id":"R3145","pred":"themeOf","subj":"T4043","obj":"T4041"},{"id":"R3146","pred":"themeOf","subj":"T4044","obj":"T4042"},{"id":"R3147","pred":"themeOf","subj":"T4045","obj":"T4040"},{"id":"R3148","pred":"themeOf","subj":"T4048","obj":"T4047"},{"id":"R3149","pred":"themeOf","subj":"T4049","obj":"T4046"},{"id":"R3150","pred":"themeOf","subj":"T4051","obj":"T4050"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Human B cells express BMP-6 receptors\nDetailed knowledge regarding expression of different BMP receptors in B cells is currently not available. To further elucidate the role of BMPs in human B cells, we performed western blot analysis for type I and type II BMP receptors. This analysis revealed that the type I receptors Act-RIA, BMP-RIB and the type II receptors BMP-RII and Act-RIIb are expressed on resting human B-cells (Figure 4). Ramos cells expressed the type I receptors Act-RIA, weakly BMP-RIB and the type II receptor BMP-RII, but more weakly than normal B cells (Figure 4). HL60 cells were used for comparison and weakly expressed Act-RIA and BMP-RII.\nTaken together, these data show that normal human B cells and Ramos cells express a set of BMP receptors, previously shown to bind BMP-6 [16]."}

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