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pmc-enju-pas

Id Subject Object Predicate Lexical cue
T191 0-5 NN denotes BMP-6
T192 6-14 VB denotes inhibits
T193 15-21 NN denotes growth
T194 22-24 IN denotes of
T195 25-31 JJ denotes mature
T196 32-37 JJ denotes human
T197 38-39 NN denotes B
T198 40-45 NN denotes cells
T199 45-46 -COLON- denotes ;
T200 47-56 NN denotes induction
T201 57-59 IN denotes of
T202 60-64 NN denotes Smad
T203 65-80 NN denotes phosphorylation
T204 81-84 CC denotes and
T205 85-97 NN denotes upregulation
T206 98-100 IN denotes of
T207 101-104 NN denotes Id1
T208 116-126 NN denotes Background
T209 127-131 NN denotes Bone
T210 132-145 JJ denotes morphogenetic
T211 146-154 NN denotes proteins
T212 155-156 -LRB- denotes (
T213 156-160 NN denotes BMPs
T214 160-161 -RRB- denotes )
T215 162-168 VB denotes belong
T216 169-171 TO denotes to
T217 172-175 DT denotes the
T218 176-181 NN denotes TGF-β
T219 182-193 NN denotes superfamily
T220 194-197 CC denotes and
T221 198-201 VB denotes are
T222 202-210 VB denotes secreted
T223 211-219 NN denotes proteins
T224 220-224 IN denotes with
T225 225-236 JJ denotes pleiotropic
T226 237-242 NN denotes roles
T227 243-245 IN denotes in
T228 246-250 JJ denotes many
T229 251-260 JJ denotes different
T230 261-265 NN denotes cell
T231 266-271 NN denotes types
T232 273-274 DT denotes A
T233 275-284 JJ denotes potential
T234 285-289 NN denotes role
T235 290-292 IN denotes of
T236 293-298 NN denotes BMP-6
T237 299-301 IN denotes in
T238 302-305 DT denotes the
T239 306-312 JJ denotes immune
T240 313-319 NN denotes system
T241 320-323 VB denotes has
T242 324-328 VB denotes been
T243 329-336 VB denotes implied
T244 337-339 IN denotes by
T245 340-347 JJ denotes various
T246 348-355 NN denotes studies
T247 356-358 IN denotes of
T248 359-368 JJ denotes malignant
T249 369-372 CC denotes and
T250 373-383 JJ denotes rheumatoid
T251 384-392 NN denotes diseases
T252 394-396 IN denotes In
T253 397-400 DT denotes the
T254 401-408 JJ denotes present
T255 409-414 NN denotes study
T256 414-415 -COMMA- denotes ,
T257 416-418 PRP denotes we
T258 419-427 VB denotes explored
T259 428-431 DT denotes the
T260 432-436 NN denotes role
T261 437-439 IN denotes of
T262 440-445 NN denotes BMP-6
T263 446-448 IN denotes in
T264 449-455 JJ denotes normal
T265 456-461 JJ denotes human
T266 462-472 JJ denotes peripheral
T267 473-478 NN denotes blood
T268 479-480 NN denotes B
T269 481-486 NN denotes cells
T270 489-496 NN denotes Results
T271 497-500 DT denotes The
T272 501-502 NN denotes B
T273 503-508 NN denotes cells
T274 509-513 VB denotes were
T275 514-519 VB denotes found
T276 520-522 TO denotes to
T277 523-530 VB denotes express
T278 531-534 NN denotes BMP
T279 535-539 NN denotes type
T280 540-541 CD denotes I
T281 542-545 CC denotes and
T282 546-550 NN denotes type
T283 551-553 CD denotes II
T284 554-563 NN denotes receptors
T285 564-567 CC denotes and
T286 568-573 NN denotes BMP-6
T287 574-581 RB denotes rapidly
T288 582-589 VB denotes induced
T289 590-605 NN denotes phosphorylation
T290 606-608 IN denotes of
T291 609-618 NN denotes Smad1/5/8
T292 620-631 RB denotes Furthermore
T293 631-632 -COMMA- denotes ,
T294 633-653 NN denotes Smad-phosphorylation
T295 654-657 VB denotes was
T296 658-666 VB denotes followed
T297 667-669 IN denotes by
T298 670-682 NN denotes upregulation
T299 683-685 IN denotes of
T300 686-689 NN denotes Id1
T301 690-694 NN denotes mRNA
T302 695-698 CC denotes and
T303 699-702 NN denotes Id1
T304 703-710 NN denotes protein
T305 710-711 -COMMA- denotes ,
T306 712-719 IN denotes whereas
T307 720-723 NN denotes Id2
T308 724-727 CC denotes and
T309 728-731 NN denotes Id3
T310 732-742 NN denotes expression
T311 743-746 VB denotes was
T312 747-750 RB denotes not
T313 751-759 VB denotes affected
T314 761-772 RB denotes Furthermore
T315 772-773 -COMMA- denotes ,
T316 774-776 PRP denotes we
T317 777-782 VB denotes found
T318 783-787 IN denotes that
T319 788-793 NN denotes BMP-6
T320 794-797 VB denotes had
T321 798-800 DT denotes an
T322 801-818 JJ denotes antiproliferative
T323 819-825 NN denotes effect
T324 826-830 CC denotes both
T325 831-833 IN denotes in
T326 834-839 NN denotes naïve
T327 840-841 -LRB- denotes (
T328 841-851 NN denotes CD19+CD27-
T329 851-852 -RRB- denotes )
T330 853-856 CC denotes and
T331 857-863 NN denotes memory
T332 864-865 NN denotes B
T333 866-871 NN denotes cells
T334 872-873 -LRB- denotes (
T335 873-883 JJ denotes CD19+CD27+
T336 883-884 -RRB- denotes )
T337 885-895 VB denotes stimulated
T338 896-900 IN denotes with
T339 901-909 NN denotes anti-IgM
T340 910-915 RB denotes alone
T341 916-918 CC denotes or
T342 919-922 DT denotes the
T343 923-931 VB denotes combined
T344 932-938 NN denotes action
T345 939-941 IN denotes of
T346 942-950 JJ denotes anti-IgM
T347 951-954 CC denotes and
T348 955-960 NN denotes CD40L
T349 962-974 RB denotes Additionally
T350 974-975 -COMMA- denotes ,
T351 976-981 NN denotes BMP-6
T352 982-989 VB denotes induced
T353 990-994 NN denotes cell
T354 995-1000 NN denotes death
T355 1001-1003 IN denotes in
T356 1004-1013 VB denotes activated
T357 1014-1020 NN denotes memory
T358 1021-1022 NN denotes B
T359 1023-1028 NN denotes cells
T360 1030-1041 RB denotes Importantly
T361 1041-1042 -COMMA- denotes ,
T362 1043-1046 DT denotes the
T363 1047-1064 JJ denotes antiproliferative
T364 1065-1071 NN denotes effect
T365 1072-1074 IN denotes of
T366 1075-1080 NN denotes BMP-6
T367 1081-1083 IN denotes in
T368 1084-1091 NN denotes B-cells
T369 1092-1095 VB denotes was
T370 1096-1106 RB denotes completely
T371 1107-1118 VB denotes neutralized
T372 1119-1121 IN denotes by
T373 1122-1125 DT denotes the
T374 1126-1133 JJ denotes natural
T375 1134-1144 NN denotes antagonist
T376 1144-1145 -COMMA- denotes ,
T377 1146-1152 NN denotes noggin
T378 1154-1165 RB denotes Furthermore
T379 1165-1166 -COMMA- denotes ,
T380 1167-1168 NN denotes B
T381 1169-1174 NN denotes cells
T382 1175-1179 VB denotes were
T383 1180-1192 VB denotes demonstrated
T384 1193-1195 TO denotes to
T385 1196-1206 VB denotes upregulate
T386 1207-1212 NN denotes BMP-6
T387 1213-1217 NN denotes mRNA
T388 1218-1222 IN denotes upon
T389 1223-1234 NN denotes stimulation
T390 1235-1239 IN denotes with
T391 1240-1248 NN denotes anti-IgM
T392 1251-1261 NN denotes Conclusion
T393 1262-1264 IN denotes In
T394 1265-1271 JJ denotes mature
T395 1272-1277 JJ denotes human
T396 1278-1279 NN denotes B
T397 1280-1285 NN denotes cells
T398 1285-1286 -COMMA- denotes ,
T399 1287-1292 NN denotes BMP-6
T400 1293-1302 VB denotes inhibited
T401 1303-1307 NN denotes cell
T402 1308-1314 NN denotes growth
T403 1314-1315 -COMMA- denotes ,
T404 1316-1319 CC denotes and
T405 1320-1327 RB denotes rapidly
T406 1328-1335 VB denotes induced
T407 1336-1351 NN denotes phosphorylation
T408 1352-1354 IN denotes of
T409 1355-1364 NN denotes Smad1/5/8
T410 1365-1373 VB denotes followed
T411 1374-1376 IN denotes by
T412 1377-1379 DT denotes an
T413 1380-1392 NN denotes upregulation
T414 1393-1395 IN denotes of
T415 1396-1399 NN denotes Id1
T1193 1692-1700 NN denotes proteins
T1194 1701-1702 -LRB- denotes (
T1195 1702-1706 NN denotes BMPs
T1196 1706-1707 -RRB- denotes )
T1197 1707-1708 -COMMA- denotes ,
T1198 1709-1711 IN denotes of
T1199 1712-1717 WDT denotes which
T1200 1718-1721 DT denotes the
T1201 1722-1728 JJ denotes latter
T1202 1729-1739 NN denotes constitute
T1203 1740-1743 DT denotes the
T1204 1744-1751 JJ denotes largest
T1205 1752-1758 NN denotes family
T1206 1760-1764 NN denotes BMPs
T1207 1765-1768 VB denotes are
T1208 1769-1774 CD denotes 30–38
T1209 1775-1778 NN denotes kDa
T1210 1779-1786 NN denotes hetero-
T1211 1787-1789 CC denotes or
T1212 1790-1801 JJ denotes homodimeric
T1213 1802-1810 NN denotes proteins
T1214 1811-1821 RB denotes originally
T1215 1822-1832 VB denotes identified
T1216 1833-1835 IN denotes by
T1217 1836-1841 PRP-DOLLAR- denotes their
T1218 1842-1849 NN denotes ability
T1219 1850-1852 TO denotes to
T1220 1853-1859 VB denotes induce
T1221 1860-1867 JJ denotes ectopic
T1222 1868-1877 NN denotes cartilage
T1223 1878-1881 CC denotes and
T1224 1882-1886 NN denotes bone
T1225 1887-1896 NN denotes formation
T1226 1897-1898 -LRB- denotes [
T1227 1898-1901 CD denotes 2,3
T1228 1901-1902 -RRB- denotes ]
T1229 1904-1911 JJ denotes Several
T1230 1912-1919 NN denotes studies
T1231 1920-1924 VB denotes have
T1232 1925-1937 VB denotes demonstrated
T1233 1938-1940 DT denotes an
T1234 1941-1950 JJ denotes essential
T1235 1951-1955 NN denotes role
T1236 1956-1958 IN denotes of
T1237 1959-1964 DT denotes these
T1238 1965-1973 NN denotes proteins
T1239 1974-1980 IN denotes during
T1240 1981-1994 NN denotes embryogenesis
T1241 1994-1995 -COMMA- denotes ,
T1242 1996-1999 CC denotes and
T1243 2000-2004 RB denotes more
T1244 2005-2013 RB denotes recently
T1245 2013-2014 -COMMA- denotes ,
T1246 2015-2019 RB denotes also
T1247 2020-2022 IN denotes in
T1248 2023-2028 JJ denotes adult
T1249 2029-2036 NN denotes tissues
T1250 2037-2038 -LRB- denotes [
T1251 2038-2039 CD denotes 1
T1252 2039-2040 -RRB- denotes ]
T1253 2042-2047 NN denotes TGF-β
T1254 2048-2051 VB denotes has
T1255 2052-2056 VB denotes been
T1256 2057-2068 RB denotes intensively
T1257 2069-2076 VB denotes studied
T1258 2077-2079 IN denotes in
T1259 2080-2086 JJ denotes normal
T1260 2087-2090 CC denotes and
T1261 2091-2100 JJ denotes malignant
T1262 2101-2115 JJ denotes haematopoietic
T1263 2116-2121 NN denotes cells
T1264 2122-2125 CC denotes and
T1265 2126-2128 VB denotes is
T1266 2129-2132 CD denotes one
T1267 2133-2135 IN denotes of
T1268 2136-2139 DT denotes the
T1269 2140-2144 RB denotes most
T1270 2145-2151 JJ denotes potent
T1271 2152-2162 JJ denotes endogenous
T1272 2163-2171 JJ denotes negative
T1273 2172-2182 NN denotes regulators
T1274 2183-2188 VB denotes known
T1275 2189-2191 TO denotes to
T1276 2192-2197 NN denotes date.
T1277 2198-2199 -LRB- denotes [
T1278 2199-2200 CD denotes 4
T1279 2200-2201 -RRB- denotes ]
T1280 2203-2205 IN denotes In
T1281 2206-2214 NN denotes contrast
T1282 2214-2215 -COMMA- denotes ,
T1283 2216-2219 DT denotes the
T1284 2220-2226 NN denotes effect
T1285 2227-2229 IN denotes of
T1286 2230-2234 NN denotes BMPs
T1287 2235-2237 IN denotes in
T1288 2238-2241 DT denotes the
T1289 2242-2248 JJ denotes immune
T1290 2249-2255 NN denotes system
T1291 2256-2259 VB denotes has
T1292 2260-2263 RB denotes not
T1293 2264-2268 VB denotes been
T1294 2269-2275 RB denotes widely
T1295 2276-2288 VB denotes investigated
T1296 2290-2292 IN denotes In
T1297 2293-2297 DT denotes that
T1298 2298-2305 NN denotes respect
T1299 2305-2306 -COMMA- denotes ,
T1300 2307-2311 NN denotes BMP-
T1301 2312-2313 CD denotes 2
T1302 2313-2314 -COMMA- denotes ,
T1303 2315-2317 CD denotes -4
T1304 2318-2321 CC denotes and
T1305 2322-2324 CD denotes -7
T1306 2325-2329 VB denotes have
T1307 2330-2334 VB denotes been
T1308 2335-2340 VB denotes found
T1309 2341-2343 TO denotes to
T1310 2344-2351 VB denotes control
T1311 2352-2367 NN denotes differentiation
T1312 2368-2370 IN denotes of
T1313 2371-2384 JJ denotes hematopoietic
T1314 2385-2389 NN denotes stem
T1315 2390-2395 NN denotes cells
T1316 2396-2397 -LRB- denotes [
T1317 2397-2398 CD denotes 5
T1318 2398-2399 -RRB- denotes ]
T1319 2400-2403 CC denotes and
T1320 2404-2409 JJ denotes early
T1321 2410-2411 NN denotes T
T1322 2412-2416 NN denotes cell
T1323 2417-2428 NN denotes development
T1324 2429-2430 -LRB- denotes [
T1325 2430-2433 CD denotes 6,7
T1326 2433-2434 -RRB- denotes ]
T1327 2436-2441 NN denotes BMP-6
T1328 2442-2445 VB denotes has
T1329 2446-2450 VB denotes been
T1330 2451-2459 VB denotes reported
T1331 2460-2462 TO denotes to
T1332 2463-2469 VB denotes reduce
T1333 2470-2473 DT denotes the
T1334 2474-2480 NN denotes number
T1335 2481-2483 IN denotes of
T1336 2484-2508 JJ denotes cobblestone-area-forming
T1337 2509-2514 NN denotes cells
T1338 2515-2517 IN denotes of
T1339 2518-2524 JJ denotes normal
T1340 2525-2530 JJ denotes human
T1341 2531-2545 JJ denotes haematopoietic
T1342 2546-2551 NN denotes cells
T1343 2552-2553 -LRB- denotes [
T1344 2553-2554 CD denotes 8
T1345 2554-2555 -RRB- denotes ]
T1346 2557-2568 RB denotes Furthermore
T1347 2568-2569 -COMMA- denotes ,
T1348 2570-2575 NN denotes BMP-2
T1349 2575-2576 -COMMA- denotes ,
T1350 2577-2579 CD denotes -4
T1351 2579-2580 -COMMA- denotes ,
T1352 2581-2582 CD denotes 6
T1353 2583-2586 CC denotes and
T1354 2587-2589 CD denotes -7
T1355 2590-2593 VB denotes had
T1356 2594-2596 DT denotes an
T1357 2597-2614 JJ denotes antiproliferative
T1358 2615-2618 CC denotes and
T1359 2619-2620 DT denotes a
T1360 2621-2633 JJ denotes proapoptotic
T1361 2634-2640 NN denotes effect
T1362 2641-2643 IN denotes on
T1363 2644-2652 JJ denotes multiple
T1364 2653-2660 NN denotes myeloma
T1365 2661-2666 NN denotes cells
T1366 2667-2668 -LRB- denotes [
T1367 2668-2672 CD denotes 9-11
T1368 2672-2673 -RRB- denotes ]
T1369 2675-2677 IN denotes In
T1370 2678-2686 NN denotes addition
T1371 2686-2687 -COMMA- denotes ,
T1372 2688-2690 IN denotes by
T1373 2691-2695 NN denotes gene
T1374 2696-2706 NN denotes expression
T1375 2707-2716 NN denotes profiling
T1376 2716-2717 -COMMA- denotes ,
T1377 2718-2723 NN denotes BMP-6
T1378 2724-2737 RB denotes significantly
T1379 2738-2747 VB denotes increased
T1380 2748-2751 DT denotes the
T1381 2752-2762 JJ denotes predictive
T1382 2763-2768 NN denotes value
T1383 2769-2772 IN denotes for
T1384 2773-2774 DT denotes a
T1385 2775-2785 JJ denotes multi-gene
T1386 2786-2795 NN denotes signature
T1387 2796-2800 NN denotes test
T1388 2801-2804 CC denotes and
T1389 2805-2808 VB denotes was
T1390 2809-2819 VB denotes associated
T1391 2820-2824 IN denotes with
T1392 2825-2826 DT denotes a
T1393 2827-2831 JJ denotes poor
T1394 2832-2839 NN denotes outcome
T1395 2840-2842 IN denotes in
T1396 2843-2850 JJ denotes diffuse
T1397 2851-2856 JJ denotes large
T1398 2857-2858 NN denotes B
T1399 2859-2863 NN denotes cell
T1400 2864-2873 NN denotes lymphomas
T1401 2874-2875 -LRB- denotes (
T1402 2875-2880 NN denotes DLBCL
T1403 2880-2881 -RRB- denotes )
T1404 2882-2883 -LRB- denotes [
T1405 2883-2885 CD denotes 12
T1406 2885-2886 -RRB- denotes ]
T1407 2888-2893 NN denotes BMP-6
T1408 2893-2894 -COMMA- denotes ,
T1409 2895-2899 IN denotes like
T1410 2900-2903 DT denotes the
T1411 2904-2909 JJ denotes other
T1412 2910-2913 NN denotes BMP
T1413 2914-2921 NN denotes members
T1414 2921-2922 -COMMA- denotes ,
T1415 2923-2930 NN denotes signals
T1416 2931-2938 IN denotes through
T1417 2939-2947 NN denotes ligation
T1418 2948-2951 CC denotes and
T1419 2952-2969 NN denotes heterodimerzation
T1420 2970-2972 IN denotes of
T1421 2973-2976 NN denotes BMP
T1422 2977-2981 NN denotes type
T1423 2982-2983 CD denotes I
T1424 2984-2985 -LRB- denotes [
T1425 2985-3004 NN denotes activin-like-kinase
T1426 3005-3006 -LRB- denotes (
T1427 3006-3009 NN denotes ALK
T1428 3009-3010 -RRB- denotes )
T1429 3010-3011 -RRB- denotes ]
T1430 3012-3015 CC denotes and
T1431 3016-3020 NN denotes type
T1432 3021-3023 CD denotes II
T1433 3024-3040 NN denotes serine-threonine
T1434 3041-3047 NN denotes kinase
T1435 3048-3057 NN denotes receptors
T1436 3057-3058 -COMMA- denotes ,
T1437 3059-3064 WDT denotes which
T1438 3065-3077 RB denotes subsequently
T1439 3078-3088 VB denotes propagates
T1440 3089-3092 DT denotes the
T1441 3093-3099 NN denotes signal
T1442 3100-3110 RB denotes downstream
T1443 3111-3113 IN denotes by
T1444 3114-3129 VB denotes phosphorylating
T1445 3130-3134 NN denotes Smad
T1446 3135-3143 NN denotes proteins
T1447 3145-3150 NN denotes BMP-6
T1448 3151-3154 MD denotes can
T1449 3155-3161 VB denotes signal
T1450 3162-3169 IN denotes through
T1451 3170-3173 DT denotes the
T1452 3174-3182 NN denotes ligation
T1453 3183-3185 IN denotes of
T1454 3186-3189 DT denotes the
T1455 3190-3194 NN denotes type
T1456 3195-3196 CD denotes I
T1457 3197-3206 NN denotes receptors
T1458 3207-3214 NNP denotes Act-RIA
T1459 3214-3215 -COMMA- denotes ,
T1460 3216-3223 NN denotes BMP-RIA
T1461 3223-3224 -COMMA- denotes ,
T1462 3225-3228 CC denotes and
T1463 3229-3236 NN denotes BMP-RIB
T1464 3237-3240 CC denotes and
T1465 3241-3244 DT denotes the
T1466 3245-3249 NN denotes type
T1467 3250-3252 CD denotes II
T1468 3253-3262 NN denotes receptors
T1469 3263-3270 NN denotes BMP-RII
T1470 3270-3271 -COMMA- denotes ,
T1471 3272-3280 NN denotes Act-RIIA
T1472 3281-3284 CC denotes and
T1473 3285-3293 NN denotes Act-RIIB
T1474 3293-3294 -COMMA- denotes ,
T1475 3295-3300 WDT denotes which
T1476 3301-3305 VB denotes lead
T1477 3306-3308 TO denotes to
T1478 3309-3312 DT denotes the
T1479 3313-3328 NN denotes phosphorylation
T1480 3329-3331 IN denotes of
T1481 3332-3335 DT denotes the
T1482 3336-3344 NN denotes receptor
T1483 3345-3350 NN denotes Smads
T1484 3351-3352 -LRB- denotes (
T1485 3352-3358 NN denotes Smad-1
T1486 3358-3359 -COMMA- denotes ,
T1487 3360-3366 NN denotes Smad-5
T1488 3366-3367 -COMMA- denotes ,
T1489 3368-3371 CC denotes and
T1490 3372-3378 NN denotes Smad-8
T1491 3378-3379 -RRB- denotes )
T1492 3381-3384 DT denotes The
T1493 3385-3387 NN denotes R-
T1494 3388-3393 NN denotes Smads
T1495 3394-3398 RB denotes then
T1496 3399-3403 VB denotes form
T1497 3404-3413 NN denotes complexes
T1498 3414-3418 IN denotes with
T1499 3419-3422 DT denotes the
T1500 3423-3430 NN denotes co-Smad
T1501 3431-3432 -LRB- denotes (
T1502 3432-3437 NN denotes Smad4
T1503 3437-3438 -RRB- denotes )
T1504 3439-3442 CC denotes and
T1505 3443-3446 VB denotes are
T1506 3447-3459 VB denotes translocated
T1507 3460-3464 IN denotes into
T1508 3465-3468 DT denotes the
T1509 3469-3476 NN denotes nucleus
T1510 3477-3482 WRB denotes where
T1511 3483-3487 PRP denotes they
T1512 3488-3493 VB denotes exert
T1513 3494-3498 NN denotes gene
T1514 3499-3509 NN denotes regulation
T1515 3510-3511 -LRB- denotes [
T1516 3511-3515 CD denotes 1,13
T1517 3515-3516 -RRB- denotes ]
T1518 3518-3523 VB denotes Given
T1519 3524-3527 DT denotes the
T1520 3528-3536 VB denotes reported
T1521 3537-3541 NN denotes role
T1522 3542-3544 IN denotes of
T1523 3545-3550 NN denotes BMP-6
T1524 3551-3553 IN denotes in
T1525 3554-3560 NN denotes B-cell
T1526 3561-3573 NN denotes malignancies
T1527 3574-3577 CC denotes and
T1528 3578-3592 JJ denotes haematopoietic
T1529 3593-3603 NN denotes progenitor
T1530 3604-3609 NN denotes cells
T1531 3609-3610 -COMMA- denotes ,
T1532 3611-3613 PRP denotes we
T1533 3614-3620 VB denotes wanted
T1534 3621-3623 TO denotes to
T1535 3624-3631 VB denotes explore
T1536 3632-3635 PRP-DOLLAR- denotes its
T1537 3636-3645 JJ denotes potential
T1538 3646-3650 NN denotes role
T1539 3651-3653 IN denotes in
T1540 3654-3660 JJ denotes normal
T1541 3661-3666 JJ denotes human
T1542 3667-3668 NN denotes B
T1543 3669-3674 NN denotes cells
T1544 3676-3678 PRP denotes We
T1545 3679-3686 VB denotes studied
T1546 3687-3690 DT denotes the
T1547 3691-3698 NN denotes effects
T1548 3699-3701 IN denotes of
T1549 3702-3707 NN denotes BMP-6
T1550 3708-3710 IN denotes on
T1551 3711-3724 NN denotes proliferation
T1552 3725-3728 CC denotes and
T1553 3729-3738 NN denotes apoptosis
T1554 3739-3741 IN denotes on
T1555 3742-3749 VB denotes resting
T1556 3750-3753 CC denotes and
T1557 3754-3764 VB denotes stimulated
T1558 3765-3766 NN denotes B
T1559 3767-3772 NN denotes cells
T1560 3774-3785 RB denotes Furthermore
T1561 3785-3786 -COMMA- denotes ,
T1562 3787-3790 DT denotes the
T1563 3791-3801 NN denotes expression
T1564 3802-3804 IN denotes of
T1565 3805-3808 NN denotes BMP
T1566 3809-3818 NN denotes receptors
T1567 3819-3822 CC denotes and
T1568 3823-3828 NN denotes BMP-6
T1569 3829-3836 VB denotes induced
T1570 3837-3847 NN denotes activation
T1571 3848-3850 IN denotes of
T1572 3851-3854 DT denotes the
T1573 3855-3859 NN denotes Smad
T1574 3860-3870 NN denotes signalling
T1575 3871-3878 NN denotes pathway
T1576 3879-3883 IN denotes with
T1577 3884-3894 JJ denotes subsequent
T1578 3895-3905 NN denotes regulation
T1579 3906-3908 IN denotes of
T1580 3909-3912 DT denotes the
T1581 3913-3919 NN denotes target
T1582 3920-3925 NN denotes genes
T1583 3926-3933 NN denotes Id1–Id4
T1584 3933-3934 -COMMA- denotes ,
T1585 3935-3939 VB denotes were
T1586 3940-3948 VB denotes resolved
T1587 3950-3957 RB denotes Finally
T1588 3957-3958 -COMMA- denotes ,
T1589 3959-3961 PRP denotes we
T1590 3962-3974 VB denotes investigated
T1591 3975-3982 IN denotes whether
T1592 3983-3984 NN denotes B
T1593 3985-3990 NN denotes cells
T1594 3991-3995 RB denotes also
T1595 3996-4000 VB denotes were
T1596 4001-4008 JJ denotes capable
T1597 4009-4011 IN denotes of
T1598 4012-4021 VB denotes producing
T1599 4022-4027 NN denotes BMP-6
T2653 4039-4044 NN denotes BMP-6
T2654 4045-4053 VB denotes inhibits
T2655 4054-4062 NN denotes anti-IgM
T2656 4063-4070 VB denotes induced
T2657 4071-4084 NN denotes proliferation
T2658 4085-4087 IN denotes of
T2659 4088-4093 JJ denotes human
T2660 4094-4095 NN denotes B
T2661 4096-4101 NN denotes cells
T2662 4102-4105 DT denotes The
T2663 4106-4113 NN denotes effects
T2664 4114-4116 IN denotes of
T2665 4117-4122 NN denotes BMP-6
T2666 4123-4125 IN denotes on
T2667 4126-4132 JJ denotes normal
T2668 4133-4136 CC denotes and
T2669 4137-4147 JJ denotes neoplastic
T2670 4148-4161 JJ denotes hematopoietic
T2671 4162-4167 NN denotes cells
T2672 4168-4176 VB denotes prompted
T2673 4177-4179 PRP denotes us
T2674 4180-4182 TO denotes to
T2675 4183-4194 VB denotes investigate
T2676 4195-4198 DT denotes the
T2677 4199-4206 NN denotes effects
T2678 4207-4209 IN denotes of
T2679 4210-4215 NN denotes BMP-6
T2680 4216-4218 IN denotes on
T2681 4219-4225 JJ denotes normal
T2682 4226-4231 JJ denotes human
T2683 4232-4233 NN denotes B
T2684 4234-4239 NN denotes cells
T2685 4241-4244 DT denotes All
T2686 4245-4256 NN denotes experiments
T2687 4257-4259 IN denotes in
T2688 4260-4264 DT denotes this
T2689 4265-4270 NN denotes study
T2690 4271-4275 VB denotes were
T2691 4276-4285 VB denotes performed
T2692 4286-4291 IN denotes under
T2693 4292-4302 JJ denotes serum-free
T2694 4303-4313 NN denotes conditions
T2695 4314-4316 IN denotes as
T2696 4317-4320 NN denotes FCS
T2697 4321-4324 VB denotes has
T2698 4325-4329 VB denotes been
T2699 4330-4335 VB denotes shown
T2700 4336-4338 TO denotes to
T2701 4339-4348 VB denotes interfere
T2702 4349-4353 IN denotes with
T2703 4354-4368 JJ denotes BMP-signalling
T2704 4369-4370 -LRB- denotes [
T2705 4370-4372 CD denotes 14
T2706 4372-4373 -RRB- denotes ]
T2707 4373-4374 -LRB- denotes (
T2708 4374-4377 JJ denotes own
T2709 4378-4390 NN denotes observations
T2710 4390-4391 -RRB- denotes )
T2711 4393-4395 TO denotes To
T2712 4396-4401 VB denotes study
T2713 4402-4405 DT denotes the
T2714 4406-4412 NN denotes effect
T2715 4413-4415 IN denotes of
T2716 4416-4421 NN denotes BMP-6
T2717 4422-4424 IN denotes on
T2718 4425-4438 NN denotes proliferation
T2719 4438-4439 -COMMA- denotes ,
T2720 4440-4447 NN denotes B-cells
T2721 4448-4452 IN denotes from
T2722 4453-4460 JJ denotes healthy
T2723 4461-4471 NN denotes volunteers
T2724 4472-4476 VB denotes were
T2725 4477-4487 VB denotes stimulated
T2726 4488-4492 IN denotes with
T2727 4493-4501 JJ denotes anti-IgM
T2728 4502-4508 CC denotes and/or
T2729 4509-4514 NN denotes CD40L
T2730 4515-4517 IN denotes in
T2731 4518-4521 DT denotes the
T2732 4522-4530 NN denotes presence
T2733 4531-4533 CC denotes or
T2734 4534-4541 NN denotes absence
T2735 4542-4544 IN denotes of
T2736 4545-4550 NN denotes BMP-6
T2737 4551-4554 IN denotes for
T2738 4555-4560 CD denotes three
T2739 4561-4565 NN denotes days
T2740 4567-4569 PRP denotes We
T2741 4570-4575 VB denotes found
T2742 4576-4580 IN denotes that
T2743 4581-4586 NN denotes BMP-6
T2744 4587-4590 VB denotes led
T2745 4591-4593 TO denotes to
T2746 4594-4595 DT denotes a
T2747 4596-4598 CD denotes 35
T2748 4598-4599 NN denotes %
T2749 4600-4604 JJ denotes mean
T2750 4605-4614 NN denotes reduction
T2751 4615-4617 IN denotes of
T2752 4618-4627 JJ denotes anti-IgM-
T2753 4628-4635 VB denotes induced
T2754 4636-4639 NN denotes DNA
T2755 4640-4649 NN denotes synthesis
T2756 4650-4651 -LRB- denotes (
T2757 4651-4652 NN denotes n
T2758 4653-4654 SYM denotes =
T2759 4655-4656 CD denotes 8
T2760 4656-4657 -COLON- denotes ;
T2761 4658-4659 NN denotes p
T2762 4660-4661 IN denotes ≤
T2763 4662-4668 CD denotes 0.0002
T2764 4668-4669 -COMMA- denotes ,
T2765 4670-4676 NN denotes Figure
T2766 4677-4679 NN denotes 1A
T2767 4679-4680 -RRB- denotes )
T2768 4682-4689 JJ denotes Similar
T2769 4690-4697 NN denotes results
T2770 4698-4702 VB denotes were
T2771 4703-4711 VB denotes obtained
T2772 4712-4715 IN denotes for
T2773 4716-4717 NN denotes B
T2774 4718-4723 NN denotes cells
T2775 4724-4731 VB denotes treated
T2776 4732-4736 IN denotes with
T2777 4737-4745 JJ denotes anti-IgM
T2778 4746-4749 CC denotes and
T2779 4750-4755 NN denotes CD40L
T2780 4756-4757 -LRB- denotes (
T2781 4757-4759 CD denotes 26
T2782 4759-4760 NN denotes %
T2783 4761-4765 JJ denotes mean
T2784 4766-4775 NN denotes reduction
T2785 4775-4776 -COMMA- denotes ,
T2786 4777-4778 NN denotes n
T2787 4779-4780 JJ denotes =
T2788 4781-4782 CD denotes 6
T2789 4782-4783 -COLON- denotes ;
T2790 4784-4785 NN denotes p
T2791 4786-4787 CC denotes ≤
T2792 4788-4793 CD denotes 0.023
T2793 4793-4794 -RRB- denotes )
T2794 4796-4799 DT denotes The
T2795 4800-4813 JJ denotes BMP-6-induced
T2796 4814-4824 NN denotes inhibition
T2797 4825-4827 IN denotes of
T2798 4828-4841 NN denotes proliferation
T2799 4842-4845 VB denotes was
T2800 4846-4860 JJ denotes dose-dependent
T2801 4861-4863 IN denotes in
T2802 4864-4868 CC denotes both
T2803 4869-4879 JJ denotes peripheral
T2804 4880-4881 NN denotes B
T2805 4882-4887 NN denotes cells
T2806 4888-4889 -LRB- denotes (
T2807 4889-4895 NN denotes Figure
T2808 4896-4898 NN denotes 1B
T2809 4898-4899 -RRB- denotes )
T2810 4900-4903 CC denotes and
T2811 4904-4907 DT denotes the
T2812 4908-4915 NN denotes Burkitt
T2813 4916-4924 NN denotes lymphoma
T2814 4925-4929 NN denotes cell
T2815 4930-4934 NN denotes line
T2816 4935-4940 NN denotes Ramos
T2817 4941-4942 -LRB- denotes (
T2818 4942-4944 CD denotes 40
T2819 4944-4945 NN denotes %
T2820 4946-4955 NN denotes reduction
T2821 4956-4958 IN denotes of
T2822 4959-4962 NN denotes DNA
T2823 4963-4972 NN denotes synthesis
T2824 4972-4973 -COMMA- denotes ,
T2825 4974-4980 NN denotes Figure
T2826 4981-4983 NN denotes 1C
T2827 4983-4984 -RRB- denotes )
T2828 4986-4989 DT denotes The
T2829 4990-4995 NN denotes BMP-6
T2830 4996-5003 NN denotes effects
T2831 5004-5009 MD denotes could
T2832 5010-5012 VB denotes be
T2833 5013-5021 VB denotes reversed
T2834 5022-5024 IN denotes by
T2835 5025-5033 NN denotes addition
T2836 5034-5036 IN denotes of
T2837 5037-5040 DT denotes the
T2838 5041-5054 JJ denotes extracellular
T2839 5055-5064 NN denotes inhibitor
T2840 5065-5071 NN denotes Noggin
T2841 5072-5073 -LRB- denotes (
T2842 5073-5079 NN denotes Figure
T2843 5080-5082 NN denotes 1D
T2844 5082-5083 -RRB- denotes )
T2845 5085-5094 RB denotes Similarly
T2846 5094-5095 -COMMA- denotes ,
T2847 5096-5097 DT denotes a
T2848 5098-5109 NN denotes combination
T2849 5110-5112 IN denotes of
T2850 5113-5116 DT denotes the
T2851 5117-5124 JJ denotes soluble
T2852 5125-5128 NN denotes BMP
T2853 5129-5138 NN denotes receptors
T2854 5139-5149 NN denotes BMP-RIB-Fc
T2855 5150-5153 CC denotes and
T2856 5154-5164 NN denotes BMP-RII-Fc
T2857 5165-5169 RB denotes also
T2858 5170-5181 VB denotes neutralized
T2859 5182-5185 DT denotes the
T2860 5186-5193 NN denotes effects
T2861 5194-5196 IN denotes of
T2862 5197-5202 NN denotes BMP-6
T2863 5203-5204 -LRB- denotes (
T2864 5204-5208 NN denotes data
T2865 5209-5212 RB denotes not
T2866 5213-5218 VB denotes shown
T2867 5218-5219 -RRB- denotes )
T2868 5221-5225 RB denotes Next
T2869 5225-5226 -COMMA- denotes ,
T2870 5227-5229 PRP denotes we
T2871 5230-5236 VB denotes wanted
T2872 5237-5239 TO denotes to
T2873 5240-5244 VB denotes test
T2874 5245-5252 IN denotes whether
T2875 5253-5258 NN denotes BMP-6
T2876 5259-5262 VB denotes had
T2877 5263-5272 JJ denotes different
T2878 5273-5279 NN denotes effect
T2879 5280-5282 IN denotes on
T2880 5283-5288 NN denotes naïve
T2881 5289-5292 CC denotes and
T2882 5293-5299 NN denotes memory
T2883 5300-5301 NN denotes B
T2884 5302-5307 NN denotes cells
T2885 5309-5314 NN denotes Naïve
T2886 5315-5316 -LRB- denotes (
T2887 5316-5326 JJ denotes CD19+CD27-
T2888 5326-5327 -RRB- denotes )
T2889 5328-5331 CC denotes and
T2890 5332-5338 NN denotes memory
T2891 5339-5340 -LRB- denotes (
T2892 5340-5350 JJ denotes CD19+CD27+
T2893 5350-5351 -RRB- denotes )
T2894 5352-5353 NN denotes B
T2895 5354-5359 NN denotes cells
T2896 5360-5364 VB denotes were
T2897 5365-5373 VB denotes isolated
T2898 5374-5378 IN denotes from
T2899 5379-5389 JJ denotes peripheral
T2900 5390-5395 NN denotes blood
T2901 5396-5398 IN denotes by
T2902 5399-5403 NN denotes cell
T2903 5404-5411 NN denotes sorting
T2904 5412-5414 IN denotes of
T2905 5415-5434 JJ denotes immunobead-isolated
T2906 5435-5440 JJ denotes CD19+
T2907 5441-5442 NN denotes B
T2908 5443-5448 NN denotes cells
T2909 5449-5450 -LRB- denotes [
T2910 5450-5452 CD denotes 15
T2911 5452-5453 -RRB- denotes ]
T2912 5453-5454 -COMMA- denotes ,
T2913 5455-5458 CC denotes and
T2914 5459-5465 VB denotes tested
T2915 5466-5469 IN denotes for
T2916 5470-5475 PRP-DOLLAR- denotes their
T2917 5476-5484 NN denotes capacity
T2918 5485-5487 TO denotes to
T2919 5488-5499 VB denotes proliferate
T2920 5500-5502 IN denotes in
T2921 5503-5506 DT denotes the
T2922 5507-5515 NN denotes presence
T2923 5516-5518 IN denotes of
T2924 5519-5524 NN denotes BMP-6
T2925 5526-5533 RB denotes However
T2926 5533-5534 -COMMA- denotes ,
T2927 5535-5540 NN denotes BMP-6
T2928 5541-5550 VB denotes inhibited
T2929 5551-5559 NN denotes anti-IgM
T2930 5560-5567 VB denotes induced
T2931 5568-5571 NN denotes DNA
T2932 5572-5581 NN denotes synthesis
T2933 5582-5584 IN denotes in
T2934 5585-5588 DT denotes the
T2935 5589-5592 CD denotes two
T2936 5593-5607 NN denotes subpopulations
T2937 5608-5610 TO denotes to
T2938 5611-5612 DT denotes a
T2939 5613-5620 JJ denotes similar
T2940 5621-5627 NN denotes extent
T2941 5627-5628 -COMMA- denotes ,
T2942 5629-5633 IN denotes with
T2943 5634-5635 DT denotes a
T2944 5636-5640 JJ denotes mean
T2945 5641-5650 NN denotes reduction
T2946 5651-5653 IN denotes of
T2947 5654-5667 NN denotes DNA-synthesis
T2948 5668-5670 IN denotes of
T2949 5671-5673 CD denotes 45
T2950 5673-5674 NN denotes %
T2951 5675-5676 -LRB- denotes (
T2952 5676-5677 NN denotes n
T2953 5678-5679 SYM denotes =
T2954 5680-5681 CD denotes 5
T2955 5681-5682 -COLON- denotes ;
T2956 5683-5684 NN denotes p
T2957 5685-5686 CC denotes ≤
T2958 5687-5692 CD denotes 0,004
T2959 5692-5693 -RRB- denotes )
T2960 5694-5697 IN denotes for
T2961 5698-5703 NN denotes naïve
T2962 5704-5705 NN denotes B
T2963 5706-5711 NN denotes cells
T2964 5712-5715 CC denotes and
T2965 5716-5718 CD denotes 48
T2966 5718-5719 NN denotes %
T2967 5720-5721 -LRB- denotes (
T2968 5721-5722 NN denotes n
T2969 5723-5724 SYM denotes =
T2970 5725-5726 CD denotes 5
T2971 5726-5727 -COLON- denotes ;
T2972 5728-5729 NN denotes p
T2973 5730-5731 CC denotes ≤
T2974 5732-5737 CD denotes 0,001
T2975 5737-5738 -RRB- denotes )
T2976 5739-5742 IN denotes for
T2977 5743-5749 NN denotes memory
T2978 5750-5751 NN denotes B
T2979 5752-5757 NN denotes cells
T2980 5758-5759 -LRB- denotes (
T2981 5759-5765 NN denotes Figure
T2982 5766-5768 NN denotes 1E
T2983 5768-5769 -RRB- denotes )
T3594 5772-5777 NN denotes BMP-6
T3595 5778-5785 VB denotes induces
T3596 5786-5790 NN denotes cell
T3597 5791-5796 NN denotes death
T3598 5797-5799 IN denotes in
T3599 5800-5805 JJ denotes human
T3600 5806-5812 NN denotes memory
T3601 5813-5814 NN denotes B
T3602 5815-5820 NN denotes cells
T3603 5821-5824 CC denotes and
T3604 5825-5830 NN denotes Ramos
T3605 5831-5836 NN denotes cells
T3606 5837-5841 RB denotes Next
T3607 5841-5842 -COMMA- denotes ,
T3608 5843-5845 PRP denotes we
T3609 5846-5852 VB denotes wanted
T3610 5853-5855 TO denotes to
T3611 5856-5865 VB denotes establish
T3612 5866-5873 IN denotes whether
T3613 5874-5879 NN denotes BMP-6
T3614 5880-5884 RB denotes also
T3615 5885-5890 MD denotes could
T3616 5891-5897 VB denotes affect
T3617 5898-5901 DT denotes the
T3618 5902-5911 NN denotes viability
T3619 5912-5914 IN denotes of
T3620 5915-5921 JJ denotes normal
T3621 5922-5923 NN denotes B
T3622 5924-5929 NN denotes cells
T3623 5931-5935 NN denotes Cell
T3624 5936-5945 NN denotes viability
T3625 5946-5949 VB denotes was
T3626 5950-5960 VB denotes determined
T3627 5961-5963 IN denotes by
T3628 5964-5973 NN denotes propidium
T3629 5974-5980 NN denotes iodide
T3630 5981-5982 -LRB- denotes (
T3631 5982-5984 NN denotes PI
T3632 5984-5985 -RRB- denotes )
T3633 5986-5994 NN denotes staining
T3634 5995-6000 IN denotes after
T3635 6001-6008 NN denotes culture
T3636 6009-6013 IN denotes with
T3637 6014-6016 CC denotes or
T3638 6017-6024 IN denotes without
T3639 6025-6030 NN denotes BMP-6
T3640 6031-6034 IN denotes for
T3641 6035-6037 CD denotes 48
T3642 6038-6043 NN denotes hours
T3643 6045-6058 RB denotes Interestingly
T3644 6058-6059 -COMMA- denotes ,
T3645 6060-6065 NN denotes BMP-6
T3646 6066-6072 VB denotes showed
T3647 6073-6074 DT denotes a
T3648 6075-6080 JJ denotes small
T3649 6080-6081 -COMMA- denotes ,
T3650 6082-6085 CC denotes but
T3651 6086-6098 JJ denotes reproducible
T3652 6099-6103 JJ denotes mean
T3653 6104-6112 NN denotes increase
T3654 6113-6115 IN denotes of
T3655 6116-6120 NN denotes cell
T3656 6121-6126 NN denotes death
T3657 6127-6131 IN denotes from
T3658 6132-6134 CD denotes 17
T3659 6135-6137 TO denotes to
T3660 6138-6140 CD denotes 23
T3661 6140-6141 NN denotes %
T3662 6142-6143 -LRB- denotes (
T3663 6143-6144 NN denotes n
T3664 6145-6146 SYM denotes =
T3665 6147-6148 CD denotes 5
T3666 6148-6149 -COLON- denotes ;
T3667 6150-6151 NN denotes p
T3668 6152-6153 CC denotes ≤
T3669 6154-6159 CD denotes 0,003
T3670 6159-6160 -RRB- denotes )
T3671 6161-6163 IN denotes in
T3672 6164-6172 JJ denotes anti-IgM
T3673 6173-6183 VB denotes stimulated
T3674 6184-6189 JJ denotes CD27+
T3675 6190-6196 NN denotes memory
T3676 6197-6198 NN denotes B
T3677 6199-6204 NN denotes cells
T3678 6206-6217 RB denotes Furthermore
T3679 6217-6218 -COMMA- denotes ,
T3680 6219-6224 NN denotes Ramos
T3681 6225-6230 NN denotes cells
T3682 6231-6237 VB denotes showed
T3683 6238-6239 DT denotes a
T3684 6240-6244 JJ denotes mean
T3685 6245-6253 NN denotes increase
T3686 6254-6256 IN denotes in
T3687 6257-6261 NN denotes cell
T3688 6262-6267 NN denotes death
T3689 6268-6272 IN denotes from
T3690 6273-6275 CD denotes 20
T3691 6276-6278 TO denotes to
T3692 6279-6281 CD denotes 50
T3693 6281-6282 NN denotes %
T3694 6283-6284 -LRB- denotes (
T3695 6284-6285 NN denotes n
T3696 6286-6287 SYM denotes =
T3697 6288-6289 CD denotes 3
T3698 6289-6290 -COMMA- denotes ,
T3699 6291-6292 NN denotes p
T3700 6293-6294 JJ denotes <
T3701 6295-6300 CD denotes 0,001
T3702 6300-6301 -COMMA- denotes ,
T3703 6302-6308 NN denotes figure
T3704 6309-6310 CD denotes 3
T3705 6310-6311 -RRB- denotes )
T3706 6312-6317 IN denotes after
T3707 6318-6323 NN denotes BMP-6
T3708 6324-6333 NN denotes treatment
T3709 6335-6337 IN denotes In
T3710 6338-6346 NN denotes contrast
T3711 6346-6347 -COMMA- denotes ,
T3712 6348-6352 NN denotes cell
T3713 6353-6358 NN denotes death
T3714 6359-6361 IN denotes of
T3715 6362-6367 JJ denotes total
T3716 6368-6373 JJ denotes CD19+
T3717 6374-6379 NN denotes cells
T3718 6380-6381 -LRB- denotes (
T3719 6381-6382 NN denotes n
T3720 6383-6384 JJ denotes =
T3721 6385-6386 CD denotes 6
T3722 6386-6387 -COLON- denotes ;
T3723 6388-6389 NN denotes p
T3724 6390-6391 VB denotes ≤
T3725 6392-6396 CD denotes 0,32
T3726 6396-6397 -COLON- denotes ;
T3727 6398-6402 NN denotes data
T3728 6403-6406 RB denotes not
T3729 6407-6412 VB denotes shown
T3730 6412-6413 -RRB- denotes )
T3731 6414-6416 CC denotes or
T3732 6417-6426 NN denotes CD27-IgG-
T3733 6427-6432 NN denotes naïve
T3734 6433-6434 NN denotes B
T3735 6435-6440 NN denotes cells
T3736 6441-6444 VB denotes was
T3737 6445-6448 RB denotes not
T3738 6449-6462 RB denotes significantly
T3739 6463-6471 VB denotes affected
T3740 6472-6473 -LRB- denotes (
T3741 6473-6474 NN denotes n
T3742 6475-6476 SYM denotes =
T3743 6477-6478 CD denotes 5
T3744 6478-6479 -COLON- denotes ;
T3745 6480-6481 NN denotes p
T3746 6482-6483 IN denotes ≤
T3747 6484-6488 CD denotes 0,65
T3748 6488-6489 -COMMA- denotes ,
T3749 6490-6496 NN denotes figure
T3750 6497-6498 CD denotes 2
T3751 6498-6499 -RRB- denotes )
T4059 6502-6507 JJ denotes Human
T4060 6508-6509 NN denotes B
T4061 6510-6515 NN denotes cells
T4062 6516-6523 VB denotes express
T4063 6524-6529 NN denotes BMP-6
T4064 6530-6539 NN denotes receptors
T4065 6540-6548 JJ denotes Detailed
T4066 6549-6558 NN denotes knowledge
T4067 6559-6568 VB denotes regarding
T4068 6569-6579 NN denotes expression
T4069 6580-6582 IN denotes of
T4070 6583-6592 JJ denotes different
T4071 6593-6596 NN denotes BMP
T4072 6597-6606 NN denotes receptors
T4073 6607-6609 IN denotes in
T4074 6610-6611 NN denotes B
T4075 6612-6617 NN denotes cells
T4076 6618-6620 VB denotes is
T4077 6621-6630 RB denotes currently
T4078 6631-6634 RB denotes not
T4079 6635-6644 JJ denotes available
T4080 6646-6648 TO denotes To
T4081 6649-6656 RB denotes further
T4082 6657-6666 VB denotes elucidate
T4083 6667-6670 DT denotes the
T4084 6671-6675 NN denotes role
T4085 6676-6678 IN denotes of
T4086 6679-6683 NN denotes BMPs
T4087 6684-6686 IN denotes in
T4088 6687-6692 JJ denotes human
T4089 6693-6694 NN denotes B
T4090 6695-6700 NN denotes cells
T4091 6700-6701 -COMMA- denotes ,
T4092 6702-6704 PRP denotes we
T4093 6705-6714 VB denotes performed
T4094 6715-6722 JJ denotes western
T4095 6723-6727 NN denotes blot
T4096 6728-6736 NN denotes analysis
T4097 6737-6740 IN denotes for
T4098 6741-6745 NN denotes type
T4099 6746-6747 CD denotes I
T4100 6748-6751 CC denotes and
T4101 6752-6756 NN denotes type
T4102 6757-6759 CD denotes II
T4103 6760-6763 NN denotes BMP
T4104 6764-6773 NN denotes receptors
T4105 6775-6779 DT denotes This
T4106 6780-6788 NN denotes analysis
T4107 6789-6797 VB denotes revealed
T4108 6798-6802 IN denotes that
T4109 6803-6806 DT denotes the
T4110 6807-6811 NN denotes type
T4111 6812-6813 CD denotes I
T4112 6814-6823 NN denotes receptors
T4113 6824-6831 NNP denotes Act-RIA
T4114 6831-6832 -COMMA- denotes ,
T4115 6833-6840 NN denotes BMP-RIB
T4116 6841-6844 CC denotes and
T4117 6845-6848 DT denotes the
T4118 6849-6853 NN denotes type
T4119 6854-6856 CD denotes II
T4120 6857-6866 NN denotes receptors
T4121 6867-6874 NN denotes BMP-RII
T4122 6875-6878 CC denotes and
T4123 6879-6887 NN denotes Act-RIIb
T4124 6888-6891 VB denotes are
T4125 6892-6901 VB denotes expressed
T4126 6902-6904 IN denotes on
T4127 6905-6912 VB denotes resting
T4128 6913-6918 JJ denotes human
T4129 6919-6926 NN denotes B-cells
T4130 6927-6928 -LRB- denotes (
T4131 6928-6934 NN denotes Figure
T4132 6935-6936 CD denotes 4
T4133 6936-6937 -RRB- denotes )
T4134 6939-6944 NN denotes Ramos
T4135 6945-6950 NN denotes cells
T4136 6951-6960 VB denotes expressed
T4137 6961-6964 DT denotes the
T4138 6965-6969 NN denotes type
T4139 6970-6971 CD denotes I
T4140 6972-6981 NN denotes receptors
T4141 6982-6989 NN denotes Act-RIA
T4142 6989-6990 -COMMA- denotes ,
T4143 6991-6997 RB denotes weakly
T4144 6998-7005 NN denotes BMP-RIB
T4145 7006-7009 CC denotes and
T4146 7010-7013 DT denotes the
T4147 7014-7018 NN denotes type
T4148 7019-7021 CD denotes II
T4149 7022-7030 NN denotes receptor
T4150 7031-7038 NN denotes BMP-RII
T4151 7038-7039 -COMMA- denotes ,
T4152 7040-7043 CC denotes but
T4153 7044-7048 RB denotes more
T4154 7049-7055 RB denotes weakly
T4155 7056-7060 IN denotes than
T4156 7061-7067 JJ denotes normal
T4157 7068-7069 NN denotes B
T4158 7070-7075 NN denotes cells
T4159 7076-7077 -LRB- denotes (
T4160 7077-7083 NN denotes Figure
T4161 7084-7085 CD denotes 4
T4162 7085-7086 -RRB- denotes )
T4163 7088-7092 NN denotes HL60
T4164 7093-7098 NN denotes cells
T4165 7099-7103 VB denotes were
T4166 7104-7108 VB denotes used
T4167 7109-7112 IN denotes for
T4168 7113-7123 NN denotes comparison
T4169 7124-7127 CC denotes and
T4170 7128-7134 RB denotes weakly
T4171 7135-7144 VB denotes expressed
T4172 7145-7152 NN denotes Act-RIA
T4173 7153-7156 CC denotes and
T4174 7157-7164 NN denotes BMP-RII
T4175 7166-7171 VB denotes Taken
T4176 7172-7180 RB denotes together
T4177 7180-7181 -COMMA- denotes ,
T4178 7182-7187 DT denotes these
T4179 7188-7192 NN denotes data
T4180 7193-7197 VB denotes show
T4181 7198-7202 IN denotes that
T4182 7203-7209 JJ denotes normal
T4183 7210-7215 JJ denotes human
T4184 7216-7217 NN denotes B
T4185 7218-7223 NN denotes cells
T4186 7224-7227 CC denotes and
T4187 7228-7233 NN denotes Ramos
T4188 7234-7239 NN denotes cells
T4189 7240-7247 VB denotes express
T4190 7248-7249 DT denotes a
T4191 7250-7253 NN denotes set
T4192 7254-7256 IN denotes of
T4193 7257-7260 NN denotes BMP
T4194 7261-7270 NN denotes receptors
T4195 7270-7271 -COMMA- denotes ,
T4196 7272-7282 RB denotes previously
T4197 7283-7288 VB denotes shown
T4198 7289-7291 TO denotes to
T4199 7292-7296 VB denotes bind
T4200 7297-7302 NN denotes BMP-6
T4201 7303-7304 -LRB- denotes [
T4202 7304-7306 CD denotes 16
T4203 7306-7307 -RRB- denotes ]
T4625 7310-7315 NN denotes BMP-6
T4626 7316-7323 VB denotes induces
T4627 7324-7339 NN denotes phosphorylation
T4628 7340-7342 IN denotes of
T4629 7343-7352 NN denotes Smad1/5/8
T4630 7353-7357 IN denotes Upon
T4631 7358-7364 NN denotes ligand
T4632 7365-7372 NN denotes binding
T4633 7372-7373 -COMMA- denotes ,
T4634 7374-7377 DT denotes the
T4635 7378-7382 NN denotes type
T4636 7383-7385 CD denotes II
T4637 7386-7394 NN denotes receptor
T4638 7395-7414 VB denotes transphosphorylates
T4639 7415-7418 CC denotes and
T4640 7419-7428 VB denotes activates
T4641 7429-7432 DT denotes the
T4642 7433-7437 NN denotes type
T4643 7438-7439 CD denotes I
T4644 7440-7448 NN denotes receptor
T4645 7450-7454 NN denotes Type
T4646 7455-7456 CD denotes I
T4647 7457-7466 NN denotes receptors
T4648 7467-7470 MD denotes can
T4649 7471-7477 VB denotes signal
T4650 7478-7481 IN denotes via
T4651 7482-7489 JJ denotes several
T4652 7490-7498 NN denotes pathways
T4653 7500-7502 PRP denotes We
T4654 7503-7511 VB denotes examined
T4655 7512-7515 DT denotes the
T4656 7516-7522 NN denotes effect
T4657 7523-7525 IN denotes of
T4658 7526-7531 NN denotes BMP-6
T4659 7532-7534 IN denotes on
T4660 7535-7539 NN denotes Smad
T4661 7540-7555 NN denotes phosphorylation
T4662 7555-7556 -COMMA- denotes ,
T4663 7557-7559 IN denotes as
T4664 7560-7563 DT denotes the
T4665 7564-7574 NN denotes activation
T4666 7575-7577 IN denotes of
T4667 7578-7582 NN denotes Smad
T4668 7583-7585 VB denotes is
T4669 7586-7596 VB denotes considered
T4670 7597-7599 TO denotes to
T4671 7600-7602 VB denotes be
T4672 7603-7604 DT denotes a
T4673 7605-7610 JJ denotes major
T4674 7611-7621 NN denotes signalling
T4675 7622-7629 NN denotes pathway
T4676 7630-7633 IN denotes for
T4677 7634-7638 NN denotes BMPs
T4678 7639-7640 -LRB- denotes [
T4679 7640-7642 CD denotes 17
T4680 7642-7643 -RRB- denotes ]
T4681 7645-7646 NN denotes B
T4682 7647-7652 NN denotes cells
T4683 7653-7657 VB denotes were
T4684 7658-7666 VB denotes cultured
T4685 7667-7669 IN denotes in
T4686 7670-7680 JJ denotes serum-free
T4687 7681-7686 NN denotes media
T4688 7687-7691 IN denotes over
T4689 7692-7697 NN denotes night
T4690 7698-7701 CC denotes and
T4691 7702-7706 RB denotes then
T4692 7707-7714 VB denotes treated
T4693 7715-7719 IN denotes with
T4694 7720-7725 NN denotes BMP-6
T4695 7726-7729 IN denotes for
T4696 7730-7737 JJ denotes various
T4697 7738-7742 NN denotes time
T4698 7743-7749 NN denotes points
T4699 7751-7756 JJ denotes Total
T4700 7757-7764 NN denotes protein
T4701 7765-7772 NN denotes lysates
T4702 7773-7777 VB denotes were
T4703 7778-7786 VB denotes prepared
T4704 7786-7787 -COMMA- denotes ,
T4705 7788-7791 CC denotes and
T4706 7792-7795 DT denotes the
T4707 7796-7803 NN denotes amounts
T4708 7804-7806 IN denotes of
T4709 7807-7810 DT denotes the
T4710 7811-7825 JJ denotes phosphorylated
T4711 7826-7831 NN denotes forms
T4712 7832-7834 IN denotes of
T4713 7835-7844 NN denotes Smad1/5/8
T4714 7845-7849 VB denotes were
T4715 7850-7860 VB denotes determined
T4716 7861-7863 IN denotes by
T4717 7864-7871 NN denotes western
T4718 7872-7876 NN denotes blot
T4719 7877-7885 NN denotes analysis
T4720 7887-7900 RB denotes Interestingly
T4721 7900-7901 -COMMA- denotes ,
T4722 7902-7911 NN denotes treatment
T4723 7912-7916 IN denotes with
T4724 7917-7920 CD denotes 500
T4725 7921-7926 NN denotes ng/ml
T4726 7927-7932 NN denotes BMP-6
T4727 7933-7940 VB denotes induced
T4728 7941-7956 NN denotes phosphorylation
T4729 7957-7959 IN denotes of
T4730 7960-7965 NNP denotes Smad.
T4731 7966-7969 DT denotes The
T4732 7970-7975 NN denotes BMP-6
T4733 7976-7983 VB denotes induced
T4734 7984-7999 NN denotes phosphorylation
T4735 8000-8003 VB denotes was
T4736 8004-8008 JJ denotes high
T4737 8009-8011 IN denotes at
T4738 8012-8015 DT denotes the
T4739 8016-8024 JJ denotes earliest
T4740 8025-8029 NN denotes time
T4741 8030-8035 NN denotes point
T4742 8036-8042 VB denotes tested
T4743 8043-8044 -LRB- denotes (
T4744 8044-8046 CD denotes 15
T4745 8047-8054 NN denotes minutes
T4746 8054-8055 -RRB- denotes )
T4747 8055-8056 -COMMA- denotes ,
T4748 8057-8060 CC denotes and
T4749 8061-8069 VB denotes remained
T4750 8070-8074 JJ denotes high
T4751 8075-8078 IN denotes for
T4752 8079-8081 IN denotes at
T4753 8082-8087 JJ denotes least
T4754 8088-8090 CD denotes 48
T4755 8091-8096 NN denotes hours
T4756 8097-8098 -LRB- denotes (
T4757 8098-8104 NN denotes Figure
T4758 8105-8106 CD denotes 5
T4759 8106-8107 -RRB- denotes )
T4760 8109-8110 DT denotes A
T4761 8111-8118 JJ denotes similar
T4762 8119-8134 NN denotes phosphorylation
T4763 8135-8138 VB denotes was
T4764 8139-8147 VB denotes observed
T4765 8148-8150 IN denotes in
T4766 8151-8156 NN denotes Ramos
T4767 8157-8162 NN denotes cells
T4768 8162-8163 -COMMA- denotes ,
T4769 8164-8167 CC denotes but
T4770 8168-8171 RB denotes not
T4771 8172-8174 IN denotes in
T4772 8175-8179 NN denotes HL60
T4773 8180-8185 NN denotes cells
T4774 8186-8187 -LRB- denotes (
T4775 8187-8193 NN denotes Figure
T4776 8194-8195 CD denotes 6
T4777 8195-8196 -RRB- denotes )
T4778 8198-8209 RB denotes Furthermore
T4779 8209-8210 -COMMA- denotes ,
T4780 8211-8213 PRP denotes we
T4781 8214-8218 RB denotes also
T4782 8219-8225 VB denotes tested
T4783 8226-8233 IN denotes whether
T4784 8234-8239 JJ denotes other
T4785 8240-8245 VB denotes known
T4786 8246-8256 JJ denotes downstream
T4787 8257-8267 NN denotes signalling
T4788 8268-8276 NN denotes pathways
T4789 8277-8279 IN denotes of
T4790 8280-8285 NN denotes BMP-6
T4791 8286-8291 MD denotes could
T4792 8292-8294 VB denotes be
T4793 8295-8304 VB denotes triggered
T4794 8305-8307 IN denotes by
T4795 8308-8313 NN denotes BMP-6
T4796 8314-8316 IN denotes in
T4797 8317-8322 JJ denotes human
T4798 8323-8324 NN denotes B
T4799 8325-8330 NN denotes cells
T4800 8332-8339 RB denotes However
T4801 8339-8340 -COMMA- denotes ,
T4802 8341-8343 PRP denotes we
T4803 8344-8347 VB denotes did
T4804 8348-8351 RB denotes not
T4805 8352-8359 VB denotes observe
T4806 8360-8363 DT denotes any
T4807 8364-8375 JJ denotes significant
T4808 8376-8383 NN denotes changes
T4809 8384-8386 IN denotes in
T4810 8387-8390 DT denotes the
T4811 8391-8396 NN denotes level
T4812 8397-8399 IN denotes of
T4813 8400-8413 NN denotes phospho-STAT3
T4814 8414-8416 CC denotes or
T4815 8417-8428 NN denotes phospho-p38
T4816 8429-8433 IN denotes upon
T4817 8434-8439 NN denotes BMP-6
T4818 8440-8449 NN denotes treatment
T4819 8450-8452 IN denotes of
T4820 8453-8454 NN denotes B
T4821 8455-8460 NN denotes cells
T4822 8461-8462 -LRB- denotes (
T4823 8462-8466 NN denotes data
T4824 8467-8470 RB denotes not
T4825 8471-8476 VB denotes shown
T4826 8476-8477 -RRB- denotes )
T5461 8480-8485 NN denotes BMP-6
T5462 8486-8493 VB denotes induces
T5463 8494-8506 NN denotes upregulation
T5464 8507-8509 IN denotes of
T5465 8510-8513 NN denotes Id1
T5466 8514-8518 RB denotes Next
T5467 8518-8519 -COMMA- denotes ,
T5468 8520-8522 PRP denotes we
T5469 8523-8529 VB denotes wanted
T5470 8530-8532 TO denotes to
T5471 8533-8540 VB denotes explore
T5472 8541-8548 IN denotes whether
T5473 8549-8552 DT denotes the
T5474 8553-8558 NN denotes BMP-6
T5475 8559-8566 VB denotes induced
T5476 8567-8582 NN denotes phosphorylation
T5477 8583-8585 IN denotes of
T5478 8586-8590 NN denotes Smad
T5479 8591-8596 CD denotes 1/5/8
T5480 8597-8601 RB denotes also
T5481 8602-8607 MD denotes could
T5482 8608-8614 VB denotes induce
T5483 8615-8630 JJ denotes transcriptional
T5484 8631-8638 NN denotes changes
T5485 8639-8641 IN denotes of
T5486 8642-8648 NN denotes target
T5487 8649-8654 NN denotes genes
T5488 8656-8658 IN denotes In
T5489 8659-8663 DT denotes this
T5490 8664-8670 NN denotes regard
T5491 8670-8671 -COMMA- denotes ,
T5492 8672-8675 DT denotes the
T5493 8676-8686 NN denotes inhibitors
T5494 8687-8689 IN denotes of
T5495 8690-8693 NN denotes DNA
T5496 8694-8701 NN denotes binding
T5497 8702-8710 NN denotes proteins
T5498 8711-8712 -LRB- denotes (
T5499 8712-8715 NN denotes Ids
T5500 8715-8716 -RRB- denotes )
T5501 8717-8720 VB denotes are
T5502 8721-8731 VB denotes considered
T5503 8732-8734 TO denotes to
T5504 8735-8737 VB denotes be
T5505 8738-8742 DT denotes some
T5506 8743-8745 IN denotes of
T5507 8746-8749 DT denotes the
T5508 8750-8755 JJ denotes major
T5509 8756-8762 NN denotes target
T5510 8763-8768 NN denotes genes
T5511 8769-8772 IN denotes for
T5512 8773-8788 JJ denotes Smad-signalling
T5513 8789-8790 -LRB- denotes [
T5514 8790-8792 CD denotes 17
T5515 8792-8793 -RRB- denotes ]
T5516 8795-8799 RB denotes Thus
T5517 8799-8800 -COMMA- denotes ,
T5518 8801-8802 NN denotes B
T5519 8803-8808 NN denotes cells
T5520 8809-8813 VB denotes were
T5521 8814-8827 JJ denotes pre-incubated
T5522 8828-8832 IN denotes over
T5523 8833-8838 NN denotes night
T5524 8839-8841 IN denotes in
T5525 8842-8848 NN denotes X-VIVO
T5526 8849-8851 CD denotes 15
T5527 8851-8852 -COMMA- denotes ,
T5528 8853-8856 CC denotes and
T5529 8857-8861 RB denotes then
T5530 8862-8870 VB denotes cultured
T5531 8871-8873 IN denotes in
T5532 8874-8880 NN denotes medium
T5533 8881-8886 RB denotes alone
T5534 8887-8889 CC denotes or
T5535 8890-8892 IN denotes in
T5536 8893-8896 DT denotes the
T5537 8897-8905 NN denotes presence
T5538 8906-8908 IN denotes of
T5539 8909-8914 NN denotes BMP-6
T5540 8915-8918 IN denotes for
T5541 8919-8926 JJ denotes various
T5542 8927-8931 NN denotes time
T5543 8932-8938 NN denotes points
T5544 8939-8945 IN denotes before
T5545 8946-8957 NN denotes preparation
T5546 8958-8960 IN denotes of
T5547 8961-8966 JJ denotes total
T5548 8967-8970 NN denotes RNA
T5549 8972-8975 DT denotes The
T5550 8976-8982 NN denotes amount
T5551 8983-8985 IN denotes of
T5552 8986-8993 NN denotes Id1–Id4
T5553 8994-8998 NN denotes mRNA
T5554 8999-9002 VB denotes was
T5555 9003-9013 VB denotes quantified
T5556 9014-9016 IN denotes by
T5557 9017-9026 JJ denotes real-time
T5558 9027-9033 NN denotes RT-PCR
T5559 9035-9048 RB denotes Interestingly
T5560 9048-9049 -COMMA- denotes ,
T5561 9050-9052 PRP denotes we
T5562 9053-9061 VB denotes observed
T5563 9062-9063 DT denotes a
T5564 9064-9072 JJ denotes specific
T5565 9073-9082 JJ denotes four-fold
T5566 9083-9095 NN denotes upregulation
T5567 9096-9098 IN denotes of
T5568 9099-9102 NN denotes Id1
T5569 9103-9107 NN denotes mRNA
T5570 9108-9110 IN denotes in
T5571 9111-9124 JJ denotes BMP-6-treated
T5572 9125-9126 NN denotes B
T5573 9127-9132 NN denotes cells
T5574 9133-9134 -LRB- denotes (
T5575 9134-9140 NN denotes Figure
T5576 9141-9142 CD denotes 7
T5577 9142-9143 -RRB- denotes )
T5578 9145-9148 DT denotes The
T5579 9149-9162 NN denotes up-regulation
T5580 9163-9165 IN denotes of
T5581 9166-9169 NN denotes Id1
T5582 9170-9174 NN denotes mRNA
T5583 9175-9178 VB denotes was
T5584 9179-9193 JJ denotes characteristic
T5585 9194-9196 IN denotes of
T5586 9197-9199 DT denotes an
T5587 9200-9205 JJ denotes early
T5588 9206-9215 JJ denotes inducible
T5589 9216-9220 NN denotes gene
T5590 9220-9221 -COMMA- denotes ,
T5591 9222-9226 IN denotes with
T5592 9227-9234 JJ denotes maximal
T5593 9235-9247 NN denotes upregulation
T5594 9248-9251 CD denotes two
T5595 9252-9257 NN denotes hours
T5596 9258-9263 IN denotes after
T5597 9264-9267 DT denotes the
T5598 9268-9276 NN denotes addition
T5599 9277-9279 IN denotes of
T5600 9280-9285 NN denotes BMP-6
T5601 9286-9289 CC denotes and
T5602 9290-9298 VB denotes returned
T5603 9299-9301 TO denotes to
T5604 9302-9310 NN denotes baseline
T5605 9311-9316 IN denotes after
T5606 9317-9319 CD denotes 24
T5607 9320-9325 NN denotes hours
T5608 9327-9329 IN denotes In
T5609 9330-9338 NN denotes contrast
T5610 9338-9339 -COMMA- denotes ,
T5611 9340-9342 DT denotes no
T5612 9343-9354 JJ denotes significant
T5613 9355-9362 NN denotes changes
T5614 9363-9367 VB denotes were
T5615 9368-9376 VB denotes observed
T5616 9377-9380 IN denotes for
T5617 9381-9384 NN denotes Id2
T5618 9385-9388 CC denotes and
T5619 9389-9392 NN denotes Id3
T5620 9393-9397 NN denotes mRNA
T5621 9397-9398 -COMMA- denotes ,
T5622 9399-9406 IN denotes whereas
T5623 9407-9422 NN denotes Id4-transcripts
T5624 9423-9427 VB denotes were
T5625 9428-9431 RB denotes not
T5626 9432-9442 JJ denotes detectable
T5627 9443-9444 -LRB- denotes (
T5628 9444-9450 NN denotes Figure
T5629 9451-9452 CD denotes 7
T5630 9452-9453 -COMMA- denotes ,
T5631 9454-9458 NN denotes data
T5632 9459-9462 RB denotes not
T5633 9463-9468 VB denotes shown
T5634 9468-9469 -RRB- denotes )
T5635 9471-9478 NN denotes Western
T5636 9479-9483 NN denotes blot
T5637 9484-9492 NN denotes analysis
T5638 9493-9501 VB denotes revealed
T5639 9502-9506 IN denotes that
T5640 9507-9510 DT denotes the
T5641 9511-9524 JJ denotes BMP-6-induced
T5642 9525-9537 NN denotes upregulation
T5643 9538-9540 IN denotes of
T5644 9541-9544 NN denotes Id1
T5645 9545-9549 NN denotes mRNA
T5646 9550-9554 RB denotes also
T5647 9555-9558 VB denotes was
T5648 9559-9569 VB denotes correlated
T5649 9570-9574 IN denotes with
T5650 9575-9587 NN denotes upregulation
T5651 9588-9590 IN denotes of
T5652 9591-9594 NN denotes Id1
T5653 9595-9602 NN denotes protein
T5654 9603-9605 RB denotes as
T5655 9606-9610 RB denotes well
T5656 9612-9615 DT denotes The
T5657 9616-9624 NN denotes increase
T5658 9625-9627 IN denotes in
T5659 9628-9631 NN denotes Id1
T5660 9632-9639 NN denotes protein
T5661 9640-9645 NN denotes level
T5662 9646-9649 VB denotes was
T5663 9650-9660 JJ denotes detectable
T5664 9661-9666 IN denotes after
T5665 9667-9670 CD denotes one
T5666 9671-9675 NN denotes hour
T5667 9676-9679 CC denotes and
T5668 9680-9689 VB denotes increased
T5669 9690-9695 IN denotes until
T5670 9696-9698 CD denotes 24
T5671 9699-9704 NN denotes hours
T5672 9705-9710 IN denotes after
T5673 9711-9716 NN denotes BMP-6
T5674 9717-9725 NN denotes addition
T5675 9725-9726 -COMMA- denotes ,
T5676 9727-9734 VB denotes showing
T5677 9735-9736 DT denotes a
T5678 9737-9744 JJ denotes 16-fold
T5679 9745-9757 NN denotes upregulation
T5680 9758-9766 VB denotes compared
T5681 9767-9771 IN denotes with
T5682 9772-9774 NN denotes t0
T5683 9775-9776 -LRB- denotes (
T5684 9776-9777 NN denotes p
T5685 9778-9779 NN denotes ≤
T5686 9780-9785 CD denotes 0.020
T5687 9785-9786 -COMMA- denotes ,
T5688 9787-9788 NN denotes n
T5689 9789-9790 SYM denotes =
T5690 9791-9792 CD denotes 4
T5691 9792-9793 -RRB- denotes )
T5692 9794-9795 -LRB- denotes (
T5693 9795-9801 NN denotes Figure
T5694 9802-9803 CD denotes 8
T5695 9804-9807 CC denotes and
T5696 9808-9809 CD denotes 9
T5697 9809-9810 -RRB- denotes )
T5698 9812-9814 IN denotes In
T5699 9815-9819 NN denotes line
T5700 9820-9824 IN denotes with
T5701 9825-9828 DT denotes the
T5702 9829-9833 NN denotes mRNA
T5703 9834-9838 NN denotes data
T5704 9838-9839 -COMMA- denotes ,
T5705 9840-9842 DT denotes no
T5706 9843-9853 JJ denotes consistent
T5707 9854-9860 NN denotes change
T5708 9861-9863 IN denotes in
T5709 9864-9867 DT denotes the
T5710 9868-9875 NN denotes amounts
T5711 9876-9878 IN denotes of
T5712 9879-9882 NN denotes Id2
T5713 9883-9886 CC denotes and
T5714 9887-9890 NN denotes Id3
T5715 9891-9898 NN denotes protein
T5716 9899-9904 MD denotes could
T5717 9905-9907 VB denotes be
T5718 9908-9916 VB denotes observed
T5719 9917-9918 -LRB- denotes (
T5720 9918-9924 NN denotes Figure
T5721 9925-9926 CD denotes 8
T5722 9927-9930 CC denotes and
T5723 9931-9932 CD denotes 9
T5724 9932-9933 -RRB- denotes )
T5725 9935-9937 PRP denotes We
T5726 9938-9942 VB denotes were
T5727 9943-9947 JJ denotes able
T5728 9948-9950 TO denotes to
T5729 9951-9956 VB denotes block
T5730 9957-9960 DT denotes the
T5731 9961-9964 NN denotes Id1
T5732 9965-9973 JJ denotes specific
T5733 9974-9978 NN denotes band
T5734 9979-9983 IN denotes with
T5735 9984-9985 DT denotes a
T5736 9986-9994 VB denotes blocking
T5737 9995-10002 NN denotes peptide
T5738 10003-10004 -LRB- denotes (
T5739 10004-10008 NN denotes data
T5740 10009-10012 RB denotes not
T5741 10013-10018 VB denotes shown
T5742 10018-10019 -RRB- denotes )
T5743 10021-10026 VB denotes Taken
T5744 10027-10035 RB denotes together
T5745 10035-10036 -COMMA- denotes ,
T5746 10037-10042 DT denotes these
T5747 10043-10047 NN denotes data
T5748 10048-10055 VB denotes suggest
T5749 10056-10060 IN denotes that
T5750 10061-10064 NN denotes Id1
T5751 10065-10070 MD denotes could
T5752 10071-10073 VB denotes be
T5753 10074-10075 DT denotes a
T5754 10076-10084 JJ denotes possible
T5755 10085-10091 NN denotes target
T5756 10092-10096 NN denotes gene
T5757 10097-10100 IN denotes for
T5758 10101-10110 VB denotes mediating
T5759 10111-10114 DT denotes the
T5760 10115-10122 NN denotes effects
T5761 10123-10125 IN denotes of
T5762 10126-10131 NN denotes BMP-6
T5763 10132-10134 IN denotes in
T5764 10135-10140 JJ denotes human
T5765 10141-10142 NN denotes B
T5766 10143-10148 NN denotes cells
T5767 10148-10149 -COMMA- denotes ,
T5768 10150-10157 IN denotes whereas
T5769 10158-10161 NN denotes Id2
T5770 10162-10165 CC denotes and
T5771 10166-10169 NN denotes Id3
T5772 10170-10173 RB denotes not
T5773 10174-10178 VB denotes seem
T5774 10179-10181 TO denotes to
T5775 10182-10184 VB denotes be
T5776 10185-10193 VB denotes involved
T6493 10196-10201 NN denotes BMP-6
T6494 10202-10212 NN denotes production
T6495 10213-10215 IN denotes in
T6496 10216-10217 NN denotes B
T6497 10218-10223 NN denotes cells
T6498 10224-10227 DT denotes The
T6499 10228-10232 NN denotes fact
T6500 10233-10237 IN denotes that
T6501 10238-10243 NN denotes BMP-6
T6502 10244-10247 VB denotes has
T6503 10248-10252 VB denotes been
T6504 10253-10261 VB denotes reported
T6505 10262-10264 TO denotes to
T6506 10265-10268 VB denotes act
T6507 10269-10271 IN denotes as
T6508 10272-10274 DT denotes an
T6509 10275-10284 JJ denotes autocrine
T6510 10285-10295 NN denotes stimulator
T6511 10296-10298 IN denotes in
T6512 10299-10311 NN denotes chondrocytes
T6513 10312-10313 -LRB- denotes [
T6514 10313-10315 CD denotes 18
T6515 10315-10316 -RRB- denotes ]
T6516 10317-10320 CC denotes and
T6517 10321-10328 NN denotes ovarium
T6518 10329-10330 -LRB- denotes [
T6519 10330-10332 CD denotes 19
T6520 10332-10333 -RRB- denotes ]
T6521 10333-10334 -COMMA- denotes ,
T6522 10335-10343 VB denotes prompted
T6523 10344-10346 PRP denotes us
T6524 10347-10349 TO denotes to
T6525 10350-10361 VB denotes investigate
T6526 10362-10369 IN denotes whether
T6527 10370-10376 JJ denotes normal
T6528 10377-10382 JJ denotes human
T6529 10383-10384 NN denotes B
T6530 10385-10390 NN denotes cells
T6531 10391-10396 MD denotes could
T6532 10397-10404 VB denotes produce
T6533 10405-10410 NN denotes BMP-6
T6534 10411-10415 IN denotes upon
T6535 10416-10427 NN denotes stimulation
T6536 10429-10434 NN denotes Ramos
T6537 10435-10440 NN denotes cells
T6538 10440-10441 -COMMA- denotes ,
T6539 10442-10447 WDT denotes which
T6540 10448-10452 VB denotes have
T6541 10453-10457 VB denotes been
T6542 10458-10467 VB denotes described
T6543 10468-10470 TO denotes to
T6544 10471-10478 VB denotes express
T6545 10479-10484 NN denotes BMP-6
T6546 10485-10489 NN denotes mRNA
T6547 10490-10502 RB denotes endogenously
T6548 10503-10504 -LRB- denotes [
T6549 10504-10506 CD denotes 20
T6550 10506-10507 -RRB- denotes ]
T6551 10507-10508 -COMMA- denotes ,
T6552 10509-10512 CC denotes and
T6553 10513-10516 DT denotes the
T6554 10517-10518 NN denotes T
T6555 10519-10523 NN denotes cell
T6556 10524-10528 NN denotes line
T6557 10529-10535 NN denotes Jurkat
T6558 10535-10536 -COMMA- denotes ,
T6559 10537-10543 VB denotes served
T6560 10544-10546 IN denotes as
T6561 10547-10555 JJ denotes positive
T6562 10556-10559 CC denotes and
T6563 10560-10568 JJ denotes negative
T6564 10569-10577 NN denotes controls
T6565 10577-10578 -COMMA- denotes ,
T6566 10579-10591 RB denotes respectively
T6567 10593-10603 JJ denotes Endogenous
T6568 10604-10609 NN denotes BMP-6
T6569 10610-10614 NN denotes mRNA
T6570 10615-10621 NN denotes levels
T6571 10622-10624 IN denotes in
T6572 10625-10631 JJ denotes normal
T6573 10632-10633 NN denotes B
T6574 10634-10639 NN denotes cells
T6575 10640-10644 VB denotes were
T6576 10645-10655 VB denotes quantified
T6577 10656-10658 IN denotes by
T6578 10659-10668 JJ denotes real-time
T6579 10669-10675 NN denotes RT-PCR
T6580 10676-10681 IN denotes after
T6581 10682-10693 NN denotes stimulation
T6582 10694-10698 IN denotes with
T6583 10699-10707 NN denotes anti-IgM
T6584 10708-10711 IN denotes for
T6585 10712-10721 JJ denotes different
T6586 10722-10726 NN denotes time
T6587 10727-10733 NN denotes points
T6588 10735-10748 RB denotes Interestingly
T6589 10748-10749 -COMMA- denotes ,
T6590 10750-10753 DT denotes the
T6591 10754-10767 NN denotes up-regulation
T6592 10768-10770 IN denotes of
T6593 10771-10776 NN denotes BMP-6
T6594 10777-10781 NN denotes mRNA
T6595 10782-10785 VB denotes was
T6596 10786-10800 JJ denotes characteristic
T6597 10801-10803 IN denotes of
T6598 10804-10806 DT denotes an
T6599 10807-10815 JJ denotes early-to
T6600 10816-10828 JJ denotes intermediate
T6601 10829-10838 JJ denotes inducible
T6602 10839-10843 NN denotes gene
T6603 10844-10848 IN denotes with
T6604 10849-10856 JJ denotes maximal
T6605 10857-10869 NN denotes upregulation
T6606 10870-10874 CD denotes four
T6607 10875-10880 NN denotes hours
T6608 10881-10886 IN denotes after
T6609 10887-10890 DT denotes the
T6610 10891-10899 NN denotes addition
T6611 10900-10902 IN denotes of
T6612 10903-10911 NN denotes anti-IgM
T6613 10913-10916 DT denotes The
T6614 10917-10922 NN denotes level
T6615 10923-10925 IN denotes of
T6616 10926-10931 NN denotes BMP-6
T6617 10932-10936 NN denotes mRNA
T6618 10937-10940 VB denotes was
T6619 10941-10945 RB denotes back
T6620 10946-10948 TO denotes to
T6621 10949-10957 NN denotes baseline
T6622 10958-10963 IN denotes after
T6623 10964-10966 CD denotes 24
T6624 10967-10972 NN denotes hours
T6625 10973-10977 IN denotes upon
T6626 10978-10989 NN denotes stimulation
T6627 10990-10991 -LRB- denotes (
T6628 10991-10997 NN denotes Figure
T6629 10998-11000 CD denotes 10
T6630 11000-11001 -RRB- denotes )
T6631 11003-11014 RB denotes Furthermore
T6632 11014-11015 -COMMA- denotes ,
T6633 11016-11020 CC denotes both
T6634 11021-11024 NN denotes FCS
T6635 11025-11028 CC denotes and
T6636 11029-11034 JJ denotes human
T6637 11035-11043 NN denotes AB-serum
T6638 11044-11051 VB denotes induced
T6639 11052-11063 JJ denotes significant
T6640 11064-11076 NN denotes upregulation
T6641 11077-11079 IN denotes of
T6642 11080-11085 NN denotes BMP-6
T6643 11086-11090 NN denotes mRNA
T6644 11091-11092 -LRB- denotes (
T6645 11092-11098 NN denotes Figure
T6646 11099-11101 CD denotes 11
T6647 11101-11102 -RRB- denotes )
T6648 11104-11117 RB denotes Interestingly
T6649 11117-11118 -COMMA- denotes ,
T6650 11119-11121 IN denotes in
T6651 11122-11123 DT denotes a
T6652 11124-11132 JJ denotes separate
T6653 11133-11138 NN denotes study
T6654 11139-11141 PRP denotes we
T6655 11142-11146 VB denotes have
T6656 11147-11152 VB denotes found
T6657 11153-11157 IN denotes that
T6658 11158-11164 JJ denotes normal
T6659 11165-11170 JJ denotes human
T6660 11171-11172 NN denotes T
T6661 11173-11178 NN denotes cells
T6662 11179-11181 VB denotes do
T6663 11182-11185 RB denotes not
T6664 11186-11193 VB denotes express
T6665 11194-11199 NN denotes BMP-6
T6666 11200-11204 NN denotes mRNA
T6667 11205-11210 IN denotes after
T6668 11211-11221 NN denotes activation
T6669 11222-11223 -LRB- denotes (
T6670 11223-11232 NNP denotes Sivertsen
T6671 11233-11235 FW denotes et
T6672 11236-11238 FW denotes al
T6673 11238-11239 -COMMA- denotes ,
T6674 11240-11250 NN denotes manuscript
T6675 11251-11253 IN denotes in
T6676 11254-11265 NN denotes preparation
T6677 11265-11266 -RRB- denotes )
T6678 11268-11272 RB denotes Next
T6679 11272-11273 -COMMA- denotes ,
T6680 11274-11276 PRP denotes we
T6681 11277-11283 VB denotes wanted
T6682 11284-11286 TO denotes to
T6683 11287-11293 VB denotes detect
T6684 11294-11299 NN denotes BMP-6
T6685 11300-11307 NN denotes protein
T6686 11308-11310 IN denotes in
T6687 11311-11317 JJ denotes normal
T6688 11318-11325 NN denotes B-cells
T6689 11326-11329 CC denotes and
T6690 11330-11336 VB denotes tested
T6691 11337-11344 JJ denotes various
T6692 11345-11357 RB denotes commercially
T6693 11358-11367 JJ denotes available
T6695 11380-11387 RB denotes However
T6696 11387-11388 -COMMA- denotes ,
T6697 11389-11391 IN denotes in
T6698 11392-11395 PRP-DOLLAR- denotes our
T6699 11396-11401 NN denotes hands
T6700 11402-11407 DT denotes these
T6701 11408-11418 JJ denotes anti-BMP-6
T6702 11419-11429 NN denotes antibodies
T6703 11430-11433 VB denotes did
T6704 11434-11438 RB denotes only
T6705 11439-11448 VB denotes recognize
T6706 11449-11452 DT denotes the
T6707 11453-11464 JJ denotes recombinant
T6708 11465-11470 NN denotes BMP-6
T6709 11471-11478 NN denotes protein
T6710 11479-11482 CC denotes and
T6711 11483-11486 RB denotes not
T6712 11487-11490 DT denotes the
T6713 11491-11497 JJ denotes native
T6714 11498-11505 NN denotes protein
T7965 11519-11525 JJ denotes Recent
T7966 11526-11533 NN denotes studies
T7967 11534-11538 VB denotes have
T7968 11539-11551 VB denotes demonstrated
T7969 11552-11554 DT denotes an
T7970 11555-11564 JJ denotes important
T7971 11565-11569 NN denotes role
T7972 11570-11573 IN denotes for
T7973 11574-11577 NN denotes BMP
T7974 11578-11589 NN denotes superfamily
T7975 11590-11597 NN denotes members
T7976 11598-11600 IN denotes in
T7977 11601-11614 JJ denotes hematopoietic
T7978 11615-11619 NN denotes stem
T7979 11620-11625 NN denotes cells
T7980 11625-11626 -COMMA- denotes ,
T7981 11627-11632 JJ denotes early
T7982 11633-11643 NN denotes thymocytes
T7983 11644-11645 -LRB- denotes [
T7984 11645-11648 CD denotes 6,7
T7985 11648-11649 -RRB- denotes ]
T7986 11650-11653 CC denotes and
T7987 11654-11660 NN denotes B-cell
T7988 11661-11673 NN denotes malignancies
T7989 11674-11675 -LRB- denotes [
T7990 11675-11682 CD denotes 8,11,12
T7991 11682-11683 -RRB- denotes ]
T7992 11683-11684 -COMMA- denotes ,
T7993 11685-11688 CC denotes but
T7994 11689-11690 DT denotes a
T7995 11691-11695 NN denotes role
T7996 11696-11699 IN denotes for
T7997 11700-11704 NN denotes BMPs
T7998 11705-11707 IN denotes in
T7999 11708-11714 JJ denotes normal
T8000 11715-11720 JJ denotes human
T8001 11721-11722 NN denotes B
T8002 11723-11728 NN denotes cells
T8003 11729-11732 VB denotes has
T8004 11733-11743 RB denotes previously
T8005 11744-11747 RB denotes not
T8006 11748-11752 VB denotes been
T8007 11753-11761 VB denotes reported
T8008 11763-11766 DT denotes The
T8009 11767-11774 JJ denotes present
T8010 11775-11780 NN denotes study
T8011 11781-11793 VB denotes demonstrated
T8012 11794-11795 DT denotes a
T8013 11796-11807 JJ denotes significant
T8014 11808-11825 JJ denotes antiproliferative
T8015 11826-11832 NN denotes effect
T8016 11833-11835 IN denotes of
T8017 11836-11841 NN denotes BMP-6
T8018 11842-11844 IN denotes in
T8019 11845-11855 JJ denotes peripheral
T8020 11856-11861 NN denotes blood
T8021 11862-11867 JJ denotes CD19+
T8022 11868-11869 NN denotes B
T8023 11870-11875 NN denotes cells
T8024 11877-11889 RB denotes Additionally
T8025 11889-11890 -COMMA- denotes ,
T8026 11891-11896 NN denotes BMP-6
T8027 11897-11904 VB denotes induced
T8028 11905-11909 NN denotes cell
T8029 11910-11915 NN denotes death
T8030 11916-11918 IN denotes in
T8031 11919-11924 JJ denotes CD27+
T8032 11925-11931 NN denotes memory
T8033 11932-11933 NN denotes B
T8034 11934-11939 NN denotes cells
T8035 11940-11942 RB denotes as
T8036 11943-11947 RB denotes well
T8037 11948-11950 IN denotes as
T8038 11951-11953 IN denotes in
T8039 11954-11955 DT denotes a
T8040 11956-11963 NN denotes Burkitt
T8041 11964-11972 NN denotes lymphoma
T8042 11973-11977 NN denotes cell
T8043 11978-11982 NN denotes line
T8044 11983-11984 -LRB- denotes (
T8045 11984-11989 NN denotes Ramos
T8046 11989-11990 -RRB- denotes )
T8047 11992-12003 RB denotes Importantly
T8048 12003-12004 -COMMA- denotes ,
T8049 12005-12010 NN denotes BMP-6
T8050 12011-12018 VB denotes induced
T8051 12019-12020 DT denotes a
T8052 12021-12026 JJ denotes rapid
T8053 12027-12030 CC denotes and
T8054 12031-12037 JJ denotes marked
T8055 12038-12046 NN denotes increase
T8056 12047-12049 IN denotes in
T8057 12050-12060 NN denotes Smad-1/5/8
T8058 12061-12076 NN denotes phosphorylation
T8059 12078-12089 RB denotes Furthermore
T8060 12089-12090 -COMMA- denotes ,
T8061 12091-12094 DT denotes the
T8062 12095-12100 NN denotes BMP-6
T8063 12101-12108 VB denotes induced
T8064 12109-12113 NN denotes Smad
T8065 12114-12129 NN denotes phosphorylation
T8066 12130-12133 VB denotes was
T8067 12134-12142 VB denotes followed
T8068 12143-12145 IN denotes by
T8069 12146-12147 DT denotes a
T8070 12148-12157 JJ denotes selective
T8071 12158-12170 NN denotes upregulation
T8072 12171-12173 IN denotes of
T8073 12174-12177 NN denotes Id1
T8074 12178-12182 NN denotes mRNA
T8075 12183-12186 CC denotes and
T8076 12187-12197 JJ denotes subsequent
T8077 12198-12201 NN denotes Id1
T8078 12202-12209 NN denotes protein
T8079 12211-12213 IN denotes In
T8080 12214-12217 DT denotes the
T8081 12218-12225 JJ denotes present
T8082 12226-12231 NN denotes study
T8083 12231-12232 -COMMA- denotes ,
T8084 12233-12236 DT denotes the
T8085 12237-12249 VB denotes demonstrated
T8086 12250-12267 JJ denotes antiproliferative
T8087 12268-12274 NN denotes effect
T8088 12275-12277 IN denotes of
T8089 12278-12283 NN denotes BMP-6
T8090 12284-12286 IN denotes in
T8091 12287-12295 JJ denotes anti-IgM
T8092 12296-12303 VB denotes treated
T8093 12304-12305 NN denotes B
T8094 12306-12311 NN denotes cells
T8095 12312-12315 VB denotes was
T8096 12316-12327 JJ denotes significant
T8097 12328-12331 CC denotes and
T8098 12332-12346 JJ denotes dose-dependent
T8099 12348-12359 RB denotes Importantly
T8100 12359-12360 -COMMA- denotes ,
T8101 12361-12364 DT denotes the
T8102 12365-12383 JJ denotes anti-proliferative
T8103 12384-12390 NN denotes effect
T8104 12391-12393 IN denotes of
T8105 12394-12399 NN denotes BMP-6
T8106 12400-12405 MD denotes could
T8107 12406-12408 VB denotes be
T8108 12409-12419 RB denotes completely
T8109 12420-12431 VB denotes neutralized
T8110 12432-12434 IN denotes by
T8111 12435-12438 DT denotes the
T8112 12439-12442 NN denotes use
T8113 12443-12445 IN denotes of
T8114 12446-12447 DT denotes a
T8115 12448-12455 JJ denotes natural
T8116 12456-12465 NN denotes inhibitor
T8117 12465-12466 -COMMA- denotes ,
T8118 12467-12474 NNP denotes Noggin.
T8119 12475-12479 DT denotes This
T8120 12480-12482 VB denotes is
T8121 12483-12485 IN denotes in
T8122 12486-12490 NN denotes line
T8123 12491-12495 IN denotes with
T8124 12496-12502 NN denotes others
T8125 12502-12503 -COMMA- denotes ,
T8126 12504-12511 VB denotes showing
T8127 12512-12516 IN denotes that
T8128 12517-12523 NN denotes Noggin
T8129 12524-12527 MD denotes can
T8130 12528-12536 VB denotes function
T8131 12537-12539 IN denotes as
T8132 12540-12541 DT denotes a
T8133 12542-12547 JJ denotes BMP-6
T8134 12548-12558 NN denotes antagonist
T8135 12559-12560 -LRB- denotes [
T8136 12560-12565 CD denotes 21,22
T8137 12565-12566 -RRB- denotes ]
T8138 12568-12570 IN denotes In
T8139 12571-12579 NN denotes addition
T8140 12579-12580 -COMMA- denotes ,
T8141 12581-12584 DT denotes the
T8142 12585-12596 NN denotes combination
T8143 12597-12599 IN denotes of
T8144 12600-12607 JJ denotes soluble
T8145 12608-12618 NN denotes BMP-RIB-Fc
T8146 12619-12622 CC denotes and
T8147 12623-12633 NN denotes BMP-RII-Fc
T8148 12634-12640 NN denotes fusion
T8149 12641-12649 NN denotes proteins
T8150 12650-12654 RB denotes also
T8151 12655-12666 VB denotes neutralized
T8152 12667-12670 DT denotes the
T8153 12671-12689 JJ denotes anti-proliferative
T8154 12690-12696 NN denotes effect
T8155 12697-12699 IN denotes of
T8156 12700-12705 NN denotes BMP-6
T8157 12706-12708 IN denotes in
T8158 12709-12714 JJ denotes human
T8159 12715-12716 NN denotes B
T8160 12717-12722 NN denotes cells
T8161 12724-12737 RB denotes Interestingly
T8162 12737-12738 -COMMA- denotes ,
T8163 12739-12741 IN denotes as
T8164 12742-12745 IN denotes for
T8165 12746-12751 JJ denotes other
T8166 12752-12755 NN denotes TGF
T8167 12756-12762 NN denotes family
T8168 12763-12770 NN denotes members
T8169 12770-12771 -COMMA- denotes ,
T8170 12772-12784 JJ denotes bifunctional
T8171 12785-12792 NN denotes effects
T8172 12793-12797 VB denotes have
T8173 12798-12802 RB denotes also
T8174 12803-12807 VB denotes been
T8175 12808-12820 VB denotes demonstrated
T8176 12821-12824 IN denotes for
T8177 12825-12829 NN denotes BMPs
T8178 12831-12838 IN denotes Whereas
T8179 12839-12846 JJ denotes several
T8180 12847-12849 IN denotes of
T8181 12850-12853 DT denotes the
T8182 12854-12858 NN denotes BMPs
T8183 12859-12863 VB denotes have
T8184 12864-12868 VB denotes been
T8185 12869-12874 VB denotes shown
T8186 12875-12877 TO denotes to
T8187 12878-12885 VB denotes promote
T8188 12886-12899 NN denotes proliferation
T8189 12900-12902 IN denotes in
T8190 12903-12910 JJ denotes various
T8191 12911-12915 NN denotes cell
T8192 12916-12921 NN denotes types
T8193 12922-12931 VB denotes including
T8194 12932-12943 NN denotes condrocytes
T8195 12944-12945 -LRB- denotes [
T8196 12945-12947 CD denotes 23
T8197 12947-12948 -RRB- denotes ]
T8198 12948-12949 -COMMA- denotes ,
T8199 12950-12955 NN denotes liver
T8200 12956-12957 -LRB- denotes [
T8201 12957-12959 CD denotes 24
T8202 12959-12960 -RRB- denotes ]
T8203 12961-12964 CC denotes and
T8204 12965-12974 NN denotes granulosa
T8205 12975-12980 NN denotes cells
T8206 12981-12982 -LRB- denotes [
T8207 12982-12984 CD denotes 25
T8208 12984-12985 -RRB- denotes ]
T8209 12985-12986 -COMMA- denotes ,
T8210 12987-13004 JJ denotes antiproliferative
T8211 13005-13012 NN denotes effects
T8212 13013-13016 CC denotes and
T8213 13017-13026 NN denotes induction
T8214 13027-13029 IN denotes of
T8215 13030-13039 NN denotes apoptosis
T8216 13040-13043 VB denotes has
T8217 13044-13048 VB denotes been
T8218 13049-13057 VB denotes reported
T8219 13058-13061 IN denotes for
T8220 13062-13063 NN denotes B
T8221 13064-13067 CC denotes and
T8222 13068-13069 NN denotes T
T8223 13070-13077 NN denotes lineage
T8224 13078-13083 NN denotes cells
T8225 13085-13092 JJ denotes Similar
T8226 13093-13100 NN denotes effects
T8227 13101-13103 IN denotes as
T8228 13104-13116 VB denotes demonstrated
T8229 13117-13120 IN denotes for
T8230 13121-13126 NN denotes BMP-6
T8231 13127-13129 IN denotes on
T8232 13130-13135 JJ denotes human
T8233 13136-13137 NN denotes B
T8234 13138-13143 NN denotes cells
T8235 13144-13146 IN denotes in
T8236 13147-13150 DT denotes the
T8237 13151-13158 JJ denotes present
T8238 13159-13164 NN denotes study
T8239 13164-13165 -COMMA- denotes ,
T8240 13166-13170 VB denotes were
T8241 13171-13183 VB denotes demonstrated
T8242 13184-13187 IN denotes for
T8243 13188-13193 NN denotes BMP-2
T8244 13193-13194 -COMMA- denotes ,
T8245 13195-13196 CD denotes 4
T8246 13196-13197 -COMMA- denotes ,
T8247 13198-13199 CD denotes 6
T8248 13200-13203 CC denotes and
T8249 13204-13206 CD denotes -7
T8250 13207-13209 IN denotes in
T8251 13210-13215 JJ denotes human
T8252 13216-13223 NN denotes myeloma
T8253 13224-13229 NN denotes cells
T8254 13230-13231 -LRB- denotes [
T8255 13231-13235 CD denotes 9-11
T8256 13235-13236 -RRB- denotes ]
T8257 13238-13243 JJ denotes Other
T8258 13244-13251 NN denotes members
T8259 13252-13254 IN denotes of
T8260 13255-13258 DT denotes the
T8261 13259-13269 NN denotes BMP-family
T8262 13270-13274 VB denotes have
T8263 13275-13279 RB denotes also
T8264 13280-13284 VB denotes been
T8265 13285-13293 VB denotes reported
T8266 13294-13296 TO denotes to
T8267 13297-13303 VB denotes induce
T8268 13304-13313 NN denotes apoptosis
T8269 13313-13314 -COMMA- denotes ,
T8270 13315-13324 VB denotes including
T8271 13325-13327 IN denotes in
T8272 13328-13333 NN denotes mouse
T8273 13334-13335 NN denotes B
T8274 13336-13343 NN denotes lineage
T8275 13344-13349 NN denotes cells
T8276 13350-13351 -LRB- denotes [
T8277 13351-13353 CD denotes 26
T8278 13353-13354 -RRB- denotes ]
T8279 13356-13368 RB denotes Additionally
T8280 13368-13369 -COMMA- denotes ,
T8281 13370-13375 NN denotes BMP-4
T8282 13376-13384 VB denotes inhibits
T8283 13385-13394 NN denotes thymocyte
T8284 13395-13408 NN denotes proliferation
T8285 13409-13410 -LRB- denotes [
T8286 13410-13411 CD denotes 6
T8287 13411-13412 -RRB- denotes ]
T8288 13414-13419 VB denotes Taken
T8289 13420-13428 RB denotes together
T8290 13428-13429 -COMMA- denotes ,
T8291 13430-13435 DT denotes these
T8292 13436-13440 NN denotes data
T8293 13441-13448 VB denotes suggest
T8294 13449-13453 IN denotes that
T8295 13454-13457 DT denotes the
T8296 13458-13462 NN denotes role
T8297 13463-13465 IN denotes of
T8298 13466-13470 NN denotes BMPs
T8299 13471-13473 IN denotes in
T8300 13474-13477 DT denotes the
T8301 13478-13488 NN denotes regulation
T8302 13489-13491 IN denotes of
T8303 13492-13505 NN denotes proliferation
T8304 13506-13509 CC denotes and
T8305 13510-13519 NN denotes apoptosis
T8306 13520-13522 VB denotes is
T8307 13523-13529 RB denotes highly
T8308 13530-13534 NN denotes cell
T8309 13535-13539 NN denotes type
T8310 13540-13549 JJ denotes dependent
T8311 13551-13553 TO denotes To
T8312 13554-13561 VB denotes examine
T8313 13562-13565 WRB denotes how
T8314 13566-13571 NN denotes BMP-6
T8315 13572-13578 VB denotes exerts
T8316 13579-13582 PRP-DOLLAR- denotes its
T8317 13583-13593 JJ denotes functional
T8318 13594-13601 NN denotes effects
T8319 13602-13604 IN denotes in
T8320 13605-13606 NN denotes B
T8321 13607-13612 NN denotes cells
T8322 13612-13613 -COMMA- denotes ,
T8323 13614-13616 PRP denotes we
T8324 13617-13625 VB denotes analysed
T8325 13626-13629 NN denotes BMP
T8326 13630-13638 NN denotes receptor
T8327 13639-13649 NN denotes expression
T8328 13650-13652 IN denotes by
T8329 13653-13660 JJ denotes western
T8330 13661-13665 NN denotes blot
T8331 13666-13674 NN denotes analysis
T8332 13676-13681 JJ denotes Human
T8333 13682-13692 JJ denotes peripheral
T8334 13693-13694 NN denotes B
T8335 13695-13700 NN denotes cells
T8336 13701-13705 VB denotes were
T8337 13706-13711 VB denotes found
T8338 13712-13714 TO denotes to
T8339 13715-13722 VB denotes express
T8340 13723-13726 DT denotes the
T8341 13727-13730 NN denotes BMP
T8342 13731-13735 NN denotes type
T8343 13736-13737 CD denotes I
T8344 13738-13747 NN denotes receptors
T8345 13748-13755 NN denotes Act-RIA
T8346 13756-13759 CC denotes and
T8347 13760-13767 NN denotes BMP-RIB
T8348 13767-13768 -COMMA- denotes ,
T8349 13769-13772 CC denotes and
T8350 13773-13776 DT denotes the
T8351 13777-13781 NN denotes type
T8352 13782-13794 NN denotes II-receptors
T8353 13795-13802 NN denotes BMP-RII
T8354 13803-13806 CC denotes and
T8355 13807-13815 NN denotes Act-RIIb
T8356 13815-13816 -COMMA- denotes ,
T8357 13817-13822 WDT denotes which
T8358 13823-13829 VB denotes signal
T8359 13830-13835 IN denotes after
T8360 13836-13843 NN denotes binding
T8361 13844-13846 IN denotes of
T8362 13847-13854 JJ denotes several
T8363 13855-13859 NN denotes BMPs
T8364 13859-13860 -COMMA- denotes ,
T8365 13861-13870 VB denotes including
T8366 13871-13876 NN denotes BMP-6
T8367 13877-13878 -LRB- denotes [
T8368 13878-13883 CD denotes 16,13
T8369 13883-13884 -RRB- denotes ]
T8370 13886-13888 TO denotes To
T8371 13889-13896 RB denotes further
T8372 13897-13904 VB denotes explore
T8373 13905-13910 NN denotes BMP-6
T8374 13911-13918 VB denotes induced
T8375 13919-13929 NN denotes signalling
T8376 13929-13930 -COMMA- denotes ,
T8377 13931-13941 NN denotes activation
T8378 13942-13944 IN denotes of
T8379 13945-13952 JJ denotes several
T8380 13953-13961 NN denotes pathways
T8381 13962-13964 VB denotes is
T8382 13965-13973 JJ denotes possible
T8383 13975-13978 DT denotes The
T8384 13979-13984 JJ denotes major
T8385 13985-13995 NN denotes signalling
T8386 13996-14003 NN denotes pathway
T8387 14004-14009 VB denotes known
T8388 14010-14012 TO denotes to
T8389 14013-14017 NN denotes date
T8390 14017-14018 -COMMA- denotes ,
T8391 14019-14021 VB denotes is
T8392 14022-14032 NN denotes activation
T8393 14033-14035 IN denotes of
T8394 14036-14043 NN denotes R-Smads
T8395 14044-14045 -LRB- denotes [
T8396 14045-14050 CD denotes 13,27
T8397 14050-14051 -RRB- denotes ]
T8398 14053-14055 IN denotes In
T8399 14056-14060 DT denotes that
T8400 14061-14068 NN denotes respect
T8401 14068-14069 -COMMA- denotes ,
T8402 14070-14074 NN denotes BMPs
T8403 14075-14079 VB denotes have
T8404 14080-14084 VB denotes been
T8405 14085-14090 VB denotes shown
T8406 14091-14093 TO denotes to
T8407 14094-14099 VB denotes exert
T8408 14100-14117 JJ denotes antiproliferative
T8409 14118-14125 NN denotes effects
T8410 14126-14128 IN denotes in
T8411 14129-14130 NN denotes B
T8412 14131-14138 NN denotes lineage
T8413 14139-14144 NN denotes cells
T8414 14145-14148 IN denotes via
T8415 14149-14164 NN denotes phosphorylation
T8416 14165-14167 IN denotes of
T8417 14168-14174 NN denotes R-Smad
T8418 14175-14176 -LRB- denotes [
T8419 14176-14181 CD denotes 11,28
T8420 14181-14182 -RRB- denotes ]
T8421 14184-14195 RB denotes Furthermore
T8422 14195-14196 -COMMA- denotes ,
T8423 14197-14202 NN denotes BMP-2
T8424 14203-14206 VB denotes has
T8425 14207-14211 VB denotes been
T8426 14212-14217 VB denotes shown
T8427 14218-14220 TO denotes to
T8428 14221-14227 VB denotes induce
T8429 14228-14238 NN denotes activation
T8430 14239-14241 IN denotes of
T8431 14242-14247 NN denotes STAT3
T8432 14248-14250 IN denotes in
T8433 14251-14258 NN denotes myeloma
T8434 14259-14264 NN denotes cells
T8435 14265-14266 -LRB- denotes [
T8436 14266-14267 CD denotes 9
T8437 14267-14268 -RRB- denotes ]
T8438 14270-14277 RB denotes However
T8439 14277-14278 -COMMA- denotes ,
T8440 14279-14294 NN denotes phosphorylation
T8441 14295-14297 IN denotes of
T8442 14298-14304 NN denotes R-Smad
T8443 14305-14308 VB denotes was
T8444 14309-14312 RB denotes not
T8445 14313-14325 VB denotes investigated
T8446 14326-14328 IN denotes in
T8447 14329-14333 DT denotes that
T8448 14334-14339 NN denotes study
T8449 14341-14346 NN denotes BMP-2
T8450 14347-14350 VB denotes has
T8451 14351-14355 RB denotes also
T8452 14356-14360 VB denotes been
T8453 14361-14366 VB denotes shown
T8454 14367-14369 TO denotes to
T8455 14370-14376 VB denotes induce
T8456 14377-14392 NN denotes phosphorylation
T8457 14393-14395 IN denotes of
T8458 14396-14399 NN denotes p38
T8459 14400-14401 -LRB- denotes [
T8460 14401-14403 CD denotes 29
T8461 14403-14404 -RRB- denotes ]
T8462 14406-14410 RB denotes Thus
T8463 14410-14411 -COMMA- denotes ,
T8464 14412-14427 NN denotes phosphorylation
T8465 14428-14430 IN denotes of
T8466 14431-14434 NN denotes p38
T8467 14434-14435 -COMMA- denotes ,
T8468 14436-14441 NN denotes STAT3
T8469 14442-14445 CC denotes and
T8470 14446-14455 NN denotes Smad1/5/8
T8471 14456-14465 VB denotes represent
T8472 14466-14475 JJ denotes important
T8473 14476-14490 JJ denotes BMP-signalling
T8474 14491-14499 NN denotes pathways
T8475 14500-14504 WDT denotes that
T8476 14505-14513 VB denotes mediated
T8477 14514-14517 DT denotes the
T8478 14518-14525 NN denotes effects
T8479 14526-14528 IN denotes of
T8480 14529-14533 NN denotes BMPs
T8481 14534-14537 CC denotes and
T8482 14538-14542 RB denotes even
T8483 14543-14553 JJ denotes cross-talk
T8484 14554-14561 IN denotes between
T8485 14562-14567 DT denotes these
T8486 14568-14576 NN denotes pathways
T8487 14577-14580 VB denotes has
T8488 14581-14585 VB denotes been
T8489 14586-14594 VB denotes reported
T8490 14595-14596 -LRB- denotes [
T8491 14596-14601 CD denotes 29,30
T8492 14601-14602 -RRB- denotes ]
T8493 14604-14606 IN denotes In
T8494 14607-14610 DT denotes the
T8495 14611-14618 JJ denotes present
T8496 14619-14624 NN denotes study
T8497 14624-14625 -COMMA- denotes ,
T8498 14626-14628 PRP denotes we
T8499 14629-14633 VB denotes were
T8500 14634-14637 RB denotes not
T8501 14638-14642 JJ denotes able
T8502 14643-14645 TO denotes to
T8503 14646-14652 VB denotes detect
T8504 14653-14666 JJ denotes BMP-6-induced
T8505 14667-14674 NN denotes changes
T8506 14675-14677 IN denotes in
T8507 14678-14681 DT denotes the
T8508 14682-14697 NN denotes phosphorylation
T8509 14698-14704 NN denotes status
T8510 14705-14707 IN denotes of
T8511 14708-14713 NN denotes STAT3
T8512 14714-14716 CC denotes or
T8513 14717-14720 NN denotes p38
T8514 14721-14723 IN denotes in
T8515 14724-14729 JJ denotes human
T8516 14730-14740 JJ denotes peripheral
T8517 14741-14742 NN denotes B
T8518 14743-14748 NN denotes cells
T8519 14750-14757 RB denotes Instead
T8520 14757-14758 -COMMA- denotes ,
T8521 14759-14760 DT denotes a
T8522 14761-14766 JJ denotes rapid
T8523 14767-14770 CC denotes and
T8524 14771-14777 JJ denotes marked
T8525 14778-14793 NN denotes phosphorylation
T8526 14794-14796 IN denotes of
T8527 14797-14806 NN denotes Smad1/5/8
T8528 14807-14810 VB denotes was
T8529 14811-14819 VB denotes revealed
T8530 14821-14823 IN denotes In
T8531 14824-14825 DT denotes a
T8532 14826-14834 JJ denotes parallel
T8533 14835-14840 NN denotes study
T8534 14840-14841 -COMMA- denotes ,
T8535 14842-14844 PRP denotes we
T8536 14845-14849 VB denotes have
T8537 14850-14855 VB denotes found
T8538 14856-14860 IN denotes that
T8539 14861-14866 JJ denotes other
T8540 14867-14871 NN denotes BMPs
T8541 14872-14876 RB denotes also
T8542 14877-14884 VB denotes induced
T8543 14885-14900 NN denotes phosphorylation
T8544 14901-14903 IN denotes of
T8545 14904-14913 NN denotes Smad1/5/8
T8546 14914-14916 IN denotes in
T8547 14917-14927 JJ denotes peripheral
T8548 14928-14929 NN denotes B
T8549 14930-14935 NN denotes cells
T8550 14936-14937 -LRB- denotes (
T8551 14937-14941 NN denotes data
T8552 14942-14945 RB denotes not
T8553 14946-14951 VB denotes shown
T8554 14951-14952 -RRB- denotes )
T8555 14954-14956 PRP denotes We
T8556 14957-14960 VB denotes are
T8557 14961-14970 RB denotes currently
T8558 14971-14979 VB denotes pursuing
T8559 14980-14990 NN denotes microarray
T8560 14991-14998 NN denotes studies
T8561 14999-15001 TO denotes to
T8562 15002-15010 VB denotes identify
T8563 15011-15014 DT denotes the
T8564 15015-15025 NN denotes signalling
T8565 15026-15034 NN denotes pathways
T8566 15035-15038 CC denotes and
T8567 15039-15045 NN denotes target
T8568 15046-15051 NN denotes genes
T8569 15052-15056 WDT denotes that
T8570 15057-15060 VB denotes are
T8571 15061-15072 RB denotes differently
T8572 15073-15082 VB denotes regulated
T8573 15083-15085 IN denotes by
T8574 15086-15089 DT denotes the
T8575 15090-15097 JJ denotes various
T8576 15098-15102 NN denotes BMPs
T8577 15103-15105 IN denotes in
T8578 15106-15111 JJ denotes human
T8579 15112-15113 NN denotes B
T8580 15114-15119 NN denotes cells
T8581 15121-15133 NN denotes Upregulation
T8582 15134-15136 IN denotes of
T8583 15137-15140 NN denotes Id1
T8584 15141-15144 IN denotes via
T8585 15145-15154 NN denotes Smad1/5/8
T8586 15155-15170 NN denotes phosphorylation
T8587 15171-15173 VB denotes is
T8588 15174-15175 DT denotes a
T8589 15176-15181 JJ denotes known
T8590 15182-15191 NN denotes mechanism
T8591 15192-15195 IN denotes for
T8592 15196-15201 NN denotes BMP-6
T8593 15202-15212 NN denotes signalling
T8594 15213-15215 IN denotes in
T8595 15216-15221 JJ denotes other
T8596 15222-15226 NN denotes cell
T8597 15227-15234 NN denotes systems
T8598 15235-15236 -LRB- denotes [
T8599 15236-15241 CD denotes 31,32
T8600 15241-15242 -RRB- denotes ]
T8601 15243-15246 CC denotes and
T8602 15247-15257 NN denotes regulation
T8603 15258-15260 IN denotes of
T8604 15261-15272 NN denotes Id-proteins
T8605 15273-15275 VB denotes is
T8606 15276-15283 VB denotes thought
T8607 15284-15286 TO denotes to
T8608 15287-15289 VB denotes be
T8609 15290-15292 DT denotes an
T8610 15293-15302 JJ denotes important
T8611 15303-15312 NN denotes mechanism
T8612 15313-15316 IN denotes for
T8613 15317-15332 NN denotes Smad-signalling
T8614 15333-15334 -LRB- denotes [
T8615 15334-15336 CD denotes 17
T8616 15336-15337 -RRB- denotes ]
T8617 15339-15341 IN denotes In
T8618 15342-15345 DT denotes the
T8619 15346-15353 JJ denotes present
T8620 15354-15359 NN denotes study
T8621 15359-15360 -COMMA- denotes ,
T8622 15361-15370 JJ denotes real-time
T8623 15371-15377 NN denotes RT-PCR
T8624 15378-15389 NN denotes experiments
T8625 15390-15398 VB denotes revealed
T8626 15399-15400 DT denotes a
T8627 15401-15409 JJ denotes specific
T8628 15410-15419 JJ denotes four-fold
T8629 15420-15432 NN denotes upregulation
T8630 15433-15436 IN denotes for
T8631 15437-15440 NN denotes Id1
T8632 15441-15443 IN denotes in
T8633 15444-15457 JJ denotes BMP-6-treated
T8634 15458-15459 NN denotes B
T8635 15460-15465 NN denotes cells
T8636 15465-15466 -COMMA- denotes ,
T8637 15467-15472 IN denotes while
T8638 15473-15476 DT denotes the
T8639 15477-15483 NN denotes amount
T8640 15484-15486 IN denotes of
T8641 15487-15494 NN denotes Id2–Id4
T8642 15495-15503 VB denotes remained
T8643 15504-15513 JJ denotes unchanged
T8644 15515-15517 IN denotes In
T8645 15518-15527 NN denotes agreement
T8646 15528-15532 IN denotes with
T8647 15533-15537 DT denotes this
T8648 15537-15538 -COMMA- denotes ,
T8649 15539-15546 JJ denotes western
T8650 15547-15551 NN denotes blot
T8651 15552-15560 NN denotes analysis
T8652 15561-15573 VB denotes demonstrated
T8653 15574-15576 DT denotes an
T8654 15577-15589 NN denotes upregulation
T8655 15590-15592 IN denotes of
T8656 15593-15596 NN denotes Id1
T8657 15597-15604 NN denotes protein
T8658 15604-15605 -COMMA- denotes ,
T8659 15606-15611 IN denotes while
T8660 15612-15615 DT denotes the
T8661 15616-15622 NN denotes amount
T8662 15623-15625 IN denotes of
T8663 15626-15629 NN denotes Id2
T8664 15630-15633 CC denotes and
T8665 15634-15637 NN denotes Id3
T8666 15638-15645 NN denotes protein
T8667 15646-15652 NN denotes levels
T8668 15653-15661 VB denotes remained
T8669 15662-15671 JJ denotes unchanged
T8670 15673-15683 RB denotes Previously
T8671 15683-15684 -COMMA- denotes ,
T8672 15685-15688 NN denotes Id1
T8673 15689-15692 VB denotes has
T8674 15693-15697 VB denotes been
T8675 15698-15708 VB denotes considered
T8676 15709-15712 RB denotes not
T8677 15713-15715 TO denotes to
T8678 15716-15718 VB denotes be
T8679 15719-15728 VB denotes expressed
T8680 15729-15731 IN denotes in
T8681 15732-15737 JJ denotes later
T8682 15738-15751 JJ denotes developmental
T8683 15752-15758 NN denotes stages
T8684 15759-15763 IN denotes than
T8685 15764-15769 JJ denotes pro-B
T8686 15770-15775 NN denotes cells
T8687 15776-15777 -LRB- denotes [
T8688 15777-15782 CD denotes 33,34
T8689 15782-15783 -RRB- denotes ]
T8690 15783-15784 -COMMA- denotes ,
T8691 15785-15788 CC denotes and
T8692 15789-15792 PRP-DOLLAR- denotes its
T8693 15793-15805 JJ denotes constitutive
T8694 15806-15816 NN denotes expression
T8695 15817-15820 VB denotes has
T8696 15821-15825 VB denotes been
T8697 15826-15834 VB denotes reported
T8698 15835-15837 TO denotes to
T8699 15838-15844 VB denotes impair
T8700 15845-15850 NN denotes mouse
T8701 15851-15852 NN denotes B
T8702 15853-15857 NN denotes cell
T8703 15858-15869 NN denotes development
T8704 15870-15871 -LRB- denotes [
T8705 15871-15873 CD denotes 35
T8706 15873-15874 -RRB- denotes ]
T8707 15876-15885 RB denotes Therefore
T8708 15885-15886 -COMMA- denotes ,
T8709 15887-15890 PRP-DOLLAR- denotes our
T8710 15891-15904 NN denotes demonstration
T8711 15905-15907 IN denotes of
T8712 15908-15911 DT denotes the
T8713 15912-15926 JJ denotes time-dependent
T8714 15927-15939 NN denotes upregulation
T8715 15940-15942 IN denotes of
T8716 15943-15946 NN denotes Id1
T8717 15947-15951 NN denotes mRNA
T8718 15952-15955 CC denotes and
T8719 15956-15963 NN denotes protein
T8720 15964-15966 IN denotes in
T8721 15967-15973 JJ denotes mature
T8722 15974-15980 JJ denotes normal
T8723 15981-15986 JJ denotes human
T8724 15987-15988 NN denotes B
T8725 15989-15994 NN denotes cells
T8726 15995-15997 VB denotes is
T8727 15998-16000 IN denotes of
T8728 16001-16011 JJ denotes particular
T8729 16012-16020 NN denotes interest
T8730 16022-16024 IN denotes In
T8731 16025-16029 DT denotes that
T8732 16030-16037 NN denotes respect
T8733 16037-16038 -COMMA- denotes ,
T8734 16039-16041 PRP denotes it
T8735 16042-16044 VB denotes is
T8736 16045-16055 JJ denotes noteworthy
T8737 16056-16060 IN denotes that
T8738 16061-16066 NN denotes TGF-β
T8739 16067-16077 NN denotes signalling
T8740 16078-16080 IN denotes in
T8741 16081-16086 JJ denotes early
T8742 16087-16090 CC denotes and
T8743 16091-16097 JJ denotes mature
T8744 16098-16099 NN denotes B
T8745 16100-16105 NN denotes cells
T8746 16106-16113 VB denotes induces
T8747 16114-16118 CC denotes both
T8748 16119-16122 NN denotes Id2
T8749 16123-16126 CC denotes and
T8750 16127-16130 NN denotes Id3
T8751 16131-16141 NN denotes expression
T8752 16142-16143 -LRB- denotes [
T8753 16143-16148 CD denotes 36,37
T8754 16148-16149 -RRB- denotes ]
T8755 16149-16150 -COMMA- denotes ,
T8756 16151-16154 CC denotes but
T8757 16155-16158 RB denotes not
T8758 16159-16162 NN denotes Id1
T8759 16163-16164 -LRB- denotes (
T8760 16164-16168 NN denotes data
T8761 16169-16172 RB denotes not
T8762 16173-16178 VB denotes shown
T8763 16178-16179 -RRB- denotes )
T8764 16181-16194 RB denotes Interestingly
T8765 16194-16195 -COMMA- denotes ,
T8766 16196-16201 DT denotes these
T8767 16202-16209 NN denotes results
T8768 16210-16214 VB denotes show
T8769 16215-16219 IN denotes that
T8770 16220-16227 JJ denotes various
T8771 16228-16235 NN denotes members
T8772 16236-16238 IN denotes of
T8773 16239-16242 DT denotes the
T8774 16243-16248 NN denotes TGF-β
T8775 16249-16255 NN denotes family
T8776 16256-16264 VB denotes regulate
T8777 16265-16267 NN denotes Id
T8778 16268-16276 NN denotes proteins
T8779 16277-16288 RB denotes differently
T8780 16290-16293 NN denotes Id2
T8781 16294-16297 CC denotes and
T8782 16298-16301 NN denotes Id3
T8783 16302-16305 VB denotes are
T8784 16306-16316 VB denotes considered
T8785 16317-16319 TO denotes to
T8786 16320-16322 VB denotes be
T8787 16323-16326 DT denotes the
T8788 16327-16329 NN denotes Id
T8789 16330-16338 NN denotes proteins
T8790 16339-16345 RB denotes mainly
T8791 16346-16355 VB denotes expressed
T8792 16356-16358 IN denotes in
T8793 16359-16365 JJ denotes mature
T8794 16366-16367 NN denotes B
T8795 16368-16373 NN denotes cells
T8796 16374-16375 -LRB- denotes [
T8797 16375-16377 CD denotes 38
T8798 16377-16378 -RRB- denotes ]
T8799 16380-16383 DT denotes The
T8800 16384-16391 JJ denotes present
T8801 16392-16397 NN denotes study
T8802 16398-16402 RB denotes also
T8803 16403-16408 VB denotes found
T8804 16409-16412 NN denotes Id2
T8805 16413-16416 CC denotes and
T8806 16417-16420 NN denotes Id3
T8807 16421-16428 NN denotes protein
T8808 16429-16431 IN denotes in
T8809 16432-16433 NN denotes B
T8810 16434-16439 NN denotes cells
T8811 16440-16442 TO denotes to
T8812 16443-16445 VB denotes be
T8813 16446-16450 RB denotes more
T8814 16451-16457 RB denotes highly
T8815 16458-16467 VB denotes expressed
T8816 16468-16472 IN denotes than
T8817 16473-16476 NN denotes Id1
T8818 16477-16479 IN denotes in
T8819 16480-16487 VB denotes resting
T8820 16488-16489 NN denotes B
T8821 16490-16495 NN denotes cells
T8822 16497-16504 RB denotes However
T8823 16504-16505 -COMMA- denotes ,
T8824 16506-16511 NN denotes BMP-6
T8825 16512-16515 VB denotes did
T8826 16516-16519 RB denotes not
T8827 16520-16526 VB denotes induce
T8828 16527-16538 JJ denotes significant
T8829 16539-16546 NN denotes changes
T8830 16547-16549 IN denotes in
T8831 16550-16553 DT denotes the
T8832 16554-16561 NN denotes protein
T8833 16562-16572 NN denotes expression
T8834 16573-16575 IN denotes of
T8835 16576-16579 NN denotes Id2
T8836 16580-16583 CC denotes and
T8837 16584-16587 NN denotes Id3
T8838 16589-16591 PRP denotes It
T8839 16592-16594 VB denotes is
T8840 16595-16603 VB denotes believed
T8841 16604-16608 IN denotes that
T8842 16609-16611 NN denotes Id
T8843 16612-16620 NN denotes proteins
T8844 16621-16626 VB denotes block
T8845 16627-16642 NN denotes differentiation
T8846 16643-16646 CC denotes and
T8847 16647-16654 VB denotes promote
T8848 16655-16668 NN denotes proliferation
T8849 16669-16671 IN denotes in
T8850 16672-16679 JJ denotes various
T8851 16680-16684 NN denotes cell
T8852 16685-16690 NN denotes types
T8853 16691-16692 -LRB- denotes [
T8854 16692-16697 CD denotes 39,33
T8855 16697-16698 -RRB- denotes ]
T8856 16700-16702 NN denotes Id
T8857 16703-16711 NN denotes proteins
T8858 16712-16715 VB denotes act
T8859 16716-16718 IN denotes as
T8860 16719-16736 JJ denotes dominant-negative
T8861 16737-16747 NN denotes inhibitors
T8862 16748-16750 IN denotes of
T8863 16751-16761 NN denotes E-proteins
T8864 16762-16765 CC denotes and
T8865 16766-16770 NN denotes Pax5
T8866 16771-16779 NN denotes function
T8867 16780-16782 IN denotes by
T8868 16783-16790 VB denotes forming
T8869 16791-16797 NN denotes dimers
T8870 16798-16802 IN denotes with
T8871 16803-16808 DT denotes these
T8872 16809-16817 NN denotes proteins
T8873 16817-16818 -COMMA- denotes ,
T8874 16819-16825 VB denotes making
T8875 16826-16830 PRP denotes them
T8876 16831-16837 JJ denotes unable
T8877 16838-16840 TO denotes to
T8878 16841-16845 VB denotes bind
T8879 16846-16849 NN denotes DNA
T8880 16851-16853 PRP denotes It
T8881 16854-16857 VB denotes has
T8882 16858-16862 VB denotes been
T8883 16863-16871 VB denotes proposed
T8884 16872-16876 IN denotes that
T8885 16877-16880 DT denotes the
T8886 16881-16888 NN denotes balance
T8887 16889-16894 IN denotes among
T8888 16895-16905 NN denotes E-proteins
T8889 16905-16906 -COMMA- denotes ,
T8890 16907-16911 NN denotes Pax5
T8891 16912-16915 CC denotes and
T8892 16916-16918 NN denotes Id
T8893 16919-16927 NN denotes proteins
T8894 16928-16933 MD denotes might
T8895 16934-16938 VB denotes have
T8896 16939-16941 DT denotes an
T8897 16942-16951 JJ denotes important
T8898 16952-16956 NN denotes role
T8899 16957-16959 IN denotes in
T8900 16960-16969 VB denotes activated
T8901 16970-16971 NN denotes B
T8902 16972-16977 NN denotes cells
T8903 16978-16979 -LRB- denotes [
T8904 16979-16981 CD denotes 38
T8905 16981-16982 -RRB- denotes ]
T8906 16984-16986 IN denotes In
T8907 16987-16991 DT denotes that
T8908 16992-16999 NN denotes respect
T8909 16999-17000 -COMMA- denotes ,
T8910 17001-17011 NN denotes E-proteins
T8911 17012-17016 VB denotes have
T8912 17017-17021 VB denotes been
T8913 17022-17032 VB denotes implicated
T8914 17033-17035 IN denotes in
T8915 17036-17040 CC denotes both
T8916 17041-17044 DT denotes the
T8917 17045-17054 NN denotes promotion
T8918 17055-17058 CC denotes and
T8919 17059-17069 NN denotes inhibition
T8920 17070-17072 IN denotes of
T8921 17073-17077 NN denotes cell
T8922 17078-17086 NN denotes survival
T8923 17087-17090 CC denotes and
T8924 17091-17097 NN denotes growth
T8925 17098-17100 IN denotes at
T8926 17101-17110 JJ denotes different
T8927 17111-17117 NN denotes points
T8928 17118-17120 IN denotes in
T8929 17121-17131 NN denotes lymphocyte
T8930 17132-17143 NN denotes development
T8931 17144-17145 -LRB- denotes [
T8932 17145-17147 CD denotes 40
T8933 17147-17148 -RRB- denotes ]
T8934 17150-17153 DT denotes The
T8935 17154-17171 JJ denotes antiproliferative
T8936 17172-17175 CC denotes and
T8937 17176-17181 NN denotes death
T8938 17182-17190 VB denotes inducing
T8939 17191-17197 NN denotes effect
T8940 17198-17200 IN denotes of
T8941 17201-17206 NN denotes BMP-6
T8942 17207-17209 IN denotes in
T8943 17210-17211 NN denotes B
T8944 17212-17217 NN denotes cells
T8945 17218-17222 IN denotes with
T8946 17223-17234 JJ denotes concomitant
T8947 17235-17247 NN denotes upregulation
T8948 17248-17250 IN denotes of
T8949 17251-17254 NN denotes Id1
T8950 17255-17262 NN denotes protein
T8951 17263-17265 VB denotes is
T8952 17266-17275 RB denotes therefore
T8953 17276-17278 IN denotes in
T8954 17279-17283 NN denotes line
T8955 17284-17288 IN denotes with
T8956 17289-17292 DT denotes the
T8957 17293-17297 NN denotes view
T8958 17298-17302 IN denotes that
T8959 17303-17305 NN denotes Id
T8960 17306-17314 NN denotes proteins
T8961 17315-17318 VB denotes are
T8962 17319-17327 VB denotes required
T8963 17328-17331 IN denotes for
T8964 17332-17335 DT denotes the
T8965 17336-17345 NN denotes induction
T8966 17346-17348 IN denotes of
T8967 17349-17355 NN denotes growth
T8968 17356-17362 NN denotes arrest
T8969 17363-17366 CC denotes and
T8970 17367-17376 NN denotes apoptosis
T8971 17377-17379 IN denotes in
T8972 17380-17392 NN denotes B-lymphocyte
T8973 17393-17404 NN denotes progenitors
T8974 17405-17407 IN denotes by
T8975 17408-17413 NN denotes TGF-β
T8976 17414-17415 -LRB- denotes [
T8977 17415-17417 CD denotes 40
T8978 17417-17418 -RRB- denotes ]
T8979 17420-17431 RB denotes Furthermore
T8980 17431-17432 -COMMA- denotes ,
T8981 17433-17435 NN denotes Id
T8982 17436-17444 NN denotes proteins
T8983 17445-17448 VB denotes are
T8984 17449-17454 VB denotes known
T8985 17455-17457 IN denotes as
T8986 17458-17467 JJ denotes important
T8987 17468-17473 NN denotes parts
T8988 17474-17476 IN denotes of
T8989 17477-17487 NN denotes signalling
T8990 17488-17496 NN denotes pathways
T8991 17497-17505 VB denotes involved
T8992 17506-17508 IN denotes in
T8993 17509-17520 NN denotes development
T8994 17520-17521 -COMMA- denotes ,
T8995 17522-17526 NN denotes cell
T8996 17527-17532 NN denotes cycle
T8997 17533-17536 CC denotes and
T8998 17537-17550 NN denotes tumorigenesis
T8999 17551-17552 -LRB- denotes [
T9000 17552-17554 CD denotes 32
T9001 17554-17555 -RRB- denotes ]
T9002 17557-17559 PRP denotes It
T9003 17560-17562 VB denotes is
T9004 17563-17567 RB denotes well
T9005 17568-17579 VB denotes established
T9006 17580-17584 IN denotes that
T9007 17585-17592 JJ denotes various
T9008 17593-17600 NN denotes members
T9009 17601-17603 IN denotes of
T9010 17604-17607 DT denotes the
T9011 17608-17610 NN denotes Id
T9012 17611-17617 NN denotes family
T9013 17618-17621 VB denotes are
T9014 17622-17635 VB denotes overexpressed
T9015 17636-17638 IN denotes in
T9016 17639-17640 DT denotes a
T9017 17641-17646 NN denotes range
T9018 17647-17649 IN denotes of
T9019 17650-17655 JJ denotes human
T9020 17656-17663 NN denotes tumours
T9021 17664-17667 CC denotes and
T9022 17668-17677 RB denotes generally
T9023 17677-17678 -COMMA- denotes ,
T9024 17679-17682 NN denotes Id1
T9025 17683-17690 VB denotes appears
T9026 17691-17693 TO denotes to
T9027 17694-17696 VB denotes be
T9028 17697-17700 DT denotes the
T9029 17701-17707 NN denotes family
T9030 17708-17714 NN denotes member
T9031 17715-17719 RB denotes most
T9032 17720-17726 RB denotes widely
T9033 17727-17740 VB denotes overexpressed
T9034 17741-17743 IN denotes in
T9035 17744-17745 DT denotes a
T9036 17746-17753 NN denotes variety
T9037 17754-17756 IN denotes of
T9038 17757-17762 JJ denotes human
T9039 17763-17775 NN denotes malignancies
T9040 17776-17777 -LRB- denotes [
T9041 17777-17779 CD denotes 41
T9042 17779-17780 -RRB- denotes ]
T9043 17780-17781 -COMMA- denotes ,
T9044 17782-17791 VB denotes including
T9045 17792-17800 JJ denotes multiple
T9046 17801-17808 NN denotes myeloma
T9047 17809-17810 -LRB- denotes [
T9048 17810-17815 CD denotes 42,32
T9049 17815-17816 -RRB- denotes ]
T9050 17818-17830 RB denotes Additionally
T9051 17830-17831 -COMMA- denotes ,
T9052 17832-17835 PRP-DOLLAR- denotes our
T9053 17836-17844 NN denotes findings
T9054 17845-17849 IN denotes that
T9055 17850-17855 NN denotes BMP-6
T9056 17856-17865 VB denotes activates
T9057 17866-17879 JJ denotes intracellular
T9058 17880-17890 NN denotes signalling
T9059 17891-17899 NN denotes pathways
T9060 17900-17902 IN denotes in
T9061 17903-17908 JJ denotes human
T9062 17909-17910 NN denotes B
T9063 17911-17916 NN denotes cells
T9064 17917-17922 MD denotes might
T9065 17923-17925 VB denotes be
T9066 17926-17928 IN denotes of
T9067 17929-17938 JJ denotes potential
T9068 17939-17957 JJ denotes pathophysiological
T9069 17958-17970 NN denotes significance
T9070 17971-17973 IN denotes in
T9071 17974-17982 NN denotes lymphoma
T9072 17983-17986 CC denotes and
T9073 17987-17999 NN denotes inflammation
T9074 18001-18005 JJ denotes High
T9075 18006-18011 NN denotes BMP-6
T9076 18012-18016 NN denotes mRNA
T9077 18017-18027 NN denotes expression
T9078 18028-18030 IN denotes in
T9079 18031-18036 NN denotes DLBCL
T9080 18037-18040 VB denotes has
T9081 18041-18045 VB denotes been
T9082 18046-18051 VB denotes shown
T9083 18052-18054 TO denotes to
T9084 18055-18064 VB denotes correlate
T9085 18065-18067 TO denotes to
T9086 18068-18080 JJ denotes unfavourable
T9087 18081-18088 NN denotes outcome
T9088 18089-18090 -LRB- denotes [
T9089 18090-18092 CD denotes 12
T9090 18092-18093 -RRB- denotes ]
T9091 18095-18097 IN denotes In
T9092 18098-18102 DT denotes this
T9093 18103-18110 NN denotes respect
T9094 18110-18111 -COMMA- denotes ,
T9095 18112-18114 PRP denotes it
T9096 18115-18117 VB denotes is
T9097 18118-18120 IN denotes of
T9098 18121-18129 NN denotes interest
T9099 18130-18134 WDT denotes that
T9100 18135-18143 VB denotes targeted
T9101 18144-18154 NN denotes expression
T9102 18155-18157 IN denotes of
T9103 18158-18161 NN denotes Id1
T9104 18162-18164 TO denotes to
T9105 18165-18178 NN denotes B-lymphocytes
T9106 18179-18187 VB denotes resulted
T9107 18188-18190 IN denotes in
T9108 18191-18199 JJ denotes aberrant
T9109 18200-18201 NN denotes B
T9110 18202-18206 NN denotes cell
T9111 18207-18218 NN denotes development
T9112 18218-18219 -COMMA- denotes ,
T9113 18220-18227 JJ denotes massive
T9114 18228-18237 NN denotes apoptosis
T9115 18237-18238 -COMMA- denotes ,
T9116 18239-18242 CC denotes and
T9117 18243-18253 JJ denotes subsequent
T9118 18254-18265 NN denotes development
T9119 18266-18268 IN denotes of
T9120 18269-18270 NN denotes B
T9121 18271-18275 NN denotes cell
T9122 18276-18285 NN denotes lymphomas
T9123 18286-18287 -LRB- denotes [
T9124 18287-18289 CD denotes 35
T9125 18289-18290 -RRB- denotes ]
T9126 18292-18300 RB denotes Moreover
T9127 18300-18301 -COMMA- denotes ,
T9128 18302-18307 NN denotes BMP-6
T9129 18308-18311 VB denotes has
T9130 18312-18316 VB denotes been
T9131 18317-18326 VB denotes suggested
T9132 18327-18329 TO denotes to
T9133 18330-18334 VB denotes play
T9134 18335-18336 DT denotes a
T9135 18337-18341 NN denotes role
T9136 18342-18344 IN denotes in
T9137 18345-18355 JJ denotes rheumatoid
T9138 18356-18365 NN denotes arthritis
T9139 18366-18367 -LRB- denotes (
T9140 18367-18369 NN denotes RA
T9141 18369-18370 -RRB- denotes )
T9142 18371-18372 -LRB- denotes [
T9143 18372-18377 CD denotes 43,44
T9144 18377-18378 -RRB- denotes ]
T9145 18379-18382 CC denotes and
T9146 18383-18391 JJ denotes elevated
T9147 18392-18398 NN denotes levels
T9148 18399-18401 IN denotes of
T9149 18402-18405 NN denotes Id1
T9150 18406-18409 CC denotes and
T9151 18410-18413 NN denotes Id3
T9152 18414-18418 VB denotes have
T9153 18419-18423 VB denotes been
T9154 18424-18429 VB denotes found
T9155 18430-18432 IN denotes in
T9156 18433-18436 DT denotes the
T9157 18437-18444 NN denotes synovia
T9158 18445-18447 IN denotes of
T9159 18448-18459 NN denotes RA-patients
T9160 18460-18461 -LRB- denotes [
T9161 18461-18463 CD denotes 45
T9162 18463-18464 -RRB- denotes ]
T9163 18466-18476 RB denotes Altogether
T9164 18476-18477 -COMMA- denotes ,
T9165 18478-18483 DT denotes these
T9166 18484-18491 NN denotes results
T9167 18492-18497 VB denotes point
T9168 18498-18500 TO denotes to
T9169 18501-18503 DT denotes an
T9170 18504-18513 JJ denotes important
T9171 18514-18518 NN denotes role
T9172 18519-18522 IN denotes for
T9173 18523-18525 NN denotes Id
T9174 18526-18534 NN denotes proteins
T9175 18535-18537 IN denotes in
T9176 18538-18541 DT denotes the
T9177 18542-18552 NN denotes regulation
T9178 18553-18555 IN denotes of
T9179 18556-18562 JJ denotes normal
T9180 18563-18564 NN denotes B
T9181 18565-18569 NN denotes cell
T9182 18570-18581 NN denotes homeostasis
T9183 18582-18585 CC denotes and
T9184 18586-18588 IN denotes in
T9185 18589-18597 NN denotes diseases
T9186 18597-18598 -COMMA- denotes ,
T9187 18599-18604 WRB denotes where
T9188 18605-18606 NN denotes B
T9189 18607-18612 NN denotes cells
T9190 18613-18616 VB denotes are
T9191 18617-18625 VB denotes involved
T9192 18627-18629 PRP denotes It
T9193 18630-18634 MD denotes will
T9194 18635-18644 RB denotes therefore
T9195 18645-18647 VB denotes be
T9196 18648-18657 JJ denotes important
T9197 18658-18660 TO denotes to
T9198 18661-18668 RB denotes further
T9199 18669-18678 VB denotes elucidate
T9200 18679-18682 DT denotes the
T9201 18683-18687 NN denotes role
T9202 18688-18690 IN denotes of
T9203 18691-18695 NN denotes Id-1
T9204 18696-18698 IN denotes in
T9205 18699-18704 JJ denotes human
T9206 18705-18706 NN denotes B
T9207 18707-18712 NN denotes cells
T9208 18713-18715 IN denotes by
T9209 18716-18725 JJ denotes selective
T9210 18726-18730 IN denotes over
T9211 18731-18741 NN denotes expression
T9212 18742-18744 CC denotes or
T9213 18745-18755 NN denotes inhibition
T9214 18756-18758 IN denotes of
T9215 18759-18763 NN denotes Id-1
T9216 18764-18768 NN denotes gene
T9217 18769-18779 NN denotes expression
T9218 18781-18786 VB denotes Given
T9219 18787-18790 DT denotes the
T9220 18791-18795 NN denotes role
T9221 18796-18798 IN denotes of
T9222 18799-18804 NN denotes BMP-6
T9223 18805-18807 IN denotes in
T9224 18808-18814 JJ denotes mature
T9225 18815-18820 JJ denotes human
T9226 18821-18822 NN denotes B
T9227 18823-18828 NN denotes cells
T9228 18829-18841 VB denotes demonstrated
T9229 18842-18846 RB denotes here
T9230 18846-18847 -COMMA- denotes ,
T9231 18848-18862 NN denotes identification
T9232 18863-18865 IN denotes of
T9233 18866-18871 NN denotes BMP-6
T9234 18872-18881 VB denotes producing
T9235 18882-18887 NN denotes cells
T9236 18888-18890 FW denotes in
T9237 18891-18895 FW denotes vivo
T9238 18896-18900 IN denotes with
T9239 18901-18912 NN denotes possibility
T9240 18913-18915 IN denotes of
T9241 18916-18927 NN denotes interaction
T9242 18928-18932 IN denotes with
T9243 18933-18938 NN denotes naïve
T9244 18939-18942 CC denotes and
T9245 18943-18949 NN denotes memory
T9246 18950-18951 NN denotes B
T9247 18952-18957 NN denotes cells
T9248 18958-18963 MD denotes might
T9249 18964-18974 VB denotes contribute
T9250 18975-18977 TO denotes to
T9251 18978-18981 DT denotes the
T9252 18982-18995 NN denotes understanding
T9253 18996-18998 IN denotes of
T9254 18999-19005 JJ denotes mature
T9255 19006-19007 NN denotes B
T9256 19008-19012 NN denotes cell
T9257 19013-19020 NN denotes biology
T9258 19022-19026 JJ denotes High
T9259 19027-19032 NN denotes BMP-6
T9260 19033-19037 NN denotes mRNA
T9261 19038-19048 NN denotes expression
T9262 19049-19051 IN denotes in
T9263 19052-19057 NN denotes DLBCL
T9264 19058-19061 VB denotes has
T9265 19062-19066 VB denotes been
T9266 19067-19075 VB denotes detected
T9267 19076-19078 IN denotes by
T9268 19079-19083 NN denotes gene
T9269 19084-19094 NN denotes expression
T9270 19095-19104 NN denotes profiling
T9271 19105-19106 -LRB- denotes [
T9272 19106-19108 CD denotes 12
T9273 19108-19109 -RRB- denotes ]
T9274 19111-19122 RB denotes Furthermore
T9275 19122-19123 -COMMA- denotes ,
T9276 19124-19134 NN denotes production
T9277 19135-19137 IN denotes of
T9278 19138-19143 NN denotes BMP-6
T9279 19144-19155 NN denotes transcripts
T9280 19156-19158 IN denotes in
T9281 19159-19165 JJ denotes normal
T9282 19166-19175 VB denotes activated
T9283 19176-19177 NN denotes B
T9284 19178-19183 NN denotes cells
T9285 19184-19187 VB denotes was
T9286 19188-19196 VB denotes detected
T9287 19197-19199 IN denotes in
T9288 19200-19203 DT denotes the
T9289 19204-19208 JJ denotes same
T9290 19209-19214 NN denotes study
T9291 19216-19218 IN denotes Of
T9292 19219-19223 NN denotes note
T9293 19223-19224 -COMMA- denotes ,
T9294 19225-19227 DT denotes an
T9295 19228-19237 JJ denotes autocrine
T9296 19238-19243 NN denotes BMP-6
T9297 19244-19248 NN denotes loop
T9298 19249-19252 VB denotes has
T9299 19253-19257 VB denotes been
T9300 19258-19266 VB denotes reported
T9301 19267-19269 IN denotes by
T9302 19270-19276 NN denotes others
T9303 19277-19279 IN denotes in
T9304 19280-19292 NN denotes chondrocytes
T9305 19293-19296 CC denotes and
T9306 19297-19299 IN denotes in
T9307 19300-19303 DT denotes the
T9308 19304-19311 NN denotes ovarium
T9309 19312-19313 -LRB- denotes [
T9310 19313-19321 CD denotes 46,19,18
T9311 19321-19322 -RRB- denotes ]
T9312 19324-19333 RB denotes Therefore
T9313 19333-19334 -COMMA- denotes ,
T9314 19335-19337 PRP denotes we
T9315 19338-19344 VB denotes wanted
T9316 19345-19347 TO denotes to
T9317 19348-19355 VB denotes explore
T9318 19356-19359 DT denotes the
T9319 19360-19371 NN denotes possibility
T9320 19372-19375 IN denotes for
T9321 19376-19378 DT denotes an
T9322 19379-19388 JJ denotes autocrine
T9323 19389-19394 NN denotes BMP-6
T9324 19395-19399 NN denotes loop
T9325 19400-19402 IN denotes in
T9326 19403-19408 JJ denotes human
T9327 19409-19410 NN denotes B
T9328 19411-19416 NN denotes cells
T9329 19418-19420 PRP denotes We
T9330 19421-19429 VB denotes analysed
T9331 19430-19433 DT denotes the
T9332 19434-19444 NN denotes expression
T9333 19445-19450 NN denotes BMP-6
T9334 19451-19455 NN denotes mRNA
T9335 19456-19458 IN denotes in
T9336 19459-19469 JJ denotes peripheral
T9337 19470-19475 NN denotes blood
T9338 19476-19477 NN denotes B
T9339 19478-19483 NN denotes cells
T9340 19484-19486 IN denotes by
T9341 19487-19496 JJ denotes real-time
T9342 19497-19500 NN denotes PCR
T9343 19500-19501 -COMMA- denotes ,
T9344 19502-19505 CC denotes and
T9345 19506-19512 NN denotes report
T9346 19513-19517 RB denotes here
T9347 19518-19521 DT denotes the
T9348 19522-19534 NN denotes upregulation
T9349 19535-19537 IN denotes of
T9350 19538-19548 JJ denotes endogenous
T9351 19549-19554 NN denotes BMP-6
T9352 19555-19566 NN denotes transcripts
T9353 19567-19572 IN denotes after
T9354 19573-19584 NN denotes stimulation
T9355 19585-19589 IN denotes with
T9356 19590-19593 NN denotes FCS
T9357 19593-19594 -COMMA- denotes ,
T9358 19595-19600 JJ denotes human
T9359 19601-19609 NN denotes AB-serum
T9360 19610-19613 CC denotes and
T9361 19613-19614 -COMMA- denotes ,
T9362 19615-19619 RB denotes most
T9363 19620-19631 RB denotes importantly
T9364 19631-19632 -COMMA- denotes ,
T9365 19633-19641 JJ denotes anti-IgM
T9366 19643-19650 RB denotes However
T9367 19650-19651 -COMMA- denotes ,
T9368 19652-19655 PRP-DOLLAR- denotes our
T9369 19656-19664 NN denotes attempts
T9370 19665-19667 TO denotes to
T9371 19668-19673 VB denotes study
T9372 19674-19679 NN denotes BMP-6
T9373 19680-19687 NN denotes protein
T9374 19688-19694 NN denotes levels
T9375 19695-19699 VB denotes were
T9376 19700-19712 JJ denotes unsuccessful
T9377 19713-19716 JJ denotes due
T9378 19717-19719 TO denotes to
T9379 19720-19728 NN denotes problems
T9380 19729-19733 IN denotes with
T9381 19734-19744 JJ denotes unspecific
T9382 19745-19752 NN denotes binding
T9383 19753-19755 IN denotes of
T9384 19756-19759 DT denotes the
T9385 19760-19770 JJ denotes anti-BMP-6
T9386 19771-19781 NN denotes antibodies
T9387 19782-19788 VB denotes tested
T9388 19788-19789 -COMMA- denotes ,
T9389 19790-19793 CC denotes and
T9390 19794-19798 NN denotes lack
T9391 19799-19801 IN denotes of
T9392 19802-19810 JJ denotes specific
T9393 19811-19819 NN denotes staining
T9394 19820-19822 IN denotes in
T9395 19823-19830 NN denotes control
T9396 19831-19836 NN denotes cells
T9397 19837-19842 VB denotes known
T9398 19843-19845 TO denotes to
T9399 19846-19853 VB denotes express
T9400 19854-19859 NN denotes BMP-6
T9401 19860-19864 NN denotes mRNA
T9402 19866-19868 IN denotes In
T9403 19869-19877 NN denotes contrast
T9404 19877-19878 -COMMA- denotes ,
T9405 19879-19882 DT denotes the
T9406 19883-19894 JJ denotes recombinant
T9407 19895-19902 NN denotes protein
T9408 19903-19906 VB denotes was
T9409 19907-19914 RB denotes readily
T9410 19915-19923 VB denotes detected
T9411 19925-19927 IN denotes In
T9412 19928-19932 DT denotes that
T9413 19933-19940 NN denotes respect
T9414 19940-19941 -COMMA- denotes ,
T9415 19942-19945 JJ denotes few
T9416 19946-19959 NN denotes investigators
T9417 19960-19964 VB denotes have
T9418 19965-19973 VB denotes detected
T9419 19974-19979 NN denotes BMP-6
T9420 19980-19987 NN denotes protein
T9421 19988-19990 IN denotes in
T9422 19991-19997 NN denotes humans
T9423 19997-19998 -COMMA- denotes ,
T9424 19999-20009 RB denotes especially
T9425 20010-20012 IN denotes in
T9426 20013-20027 JJ denotes non-pathogenic
T9427 20028-20034 NN denotes tissue
T9428 20036-20039 DT denotes The
T9429 20040-20051 NN denotes possibility
T9430 20052-20054 IN denotes of
T9431 20055-20060 NN denotes BMP-6
T9432 20061-20071 NN denotes production
T9433 20072-20074 IN denotes in
T9434 20075-20080 JJ denotes human
T9435 20081-20088 NN denotes B-cells
T9436 20089-20091 VB denotes is
T9437 20092-20094 IN denotes in
T9438 20095-20099 NN denotes line
T9439 20100-20104 IN denotes with
T9440 20105-20106 DT denotes a
T9441 20107-20113 JJ denotes recent
T9442 20114-20118 NN denotes work
T9443 20119-20123 WDT denotes that
T9444 20124-20132 VB denotes reported
T9445 20133-20136 DT denotes the
T9446 20137-20147 NN denotes production
T9447 20148-20150 IN denotes of
T9448 20151-20156 NN denotes BMP-6
T9449 20157-20159 IN denotes in
T9450 20160-20165 NN denotes mouse
T9451 20166-20167 NN denotes B
T9452 20168-20173 NN denotes cells
T9453 20173-20174 -COMMA- denotes ,
T9454 20175-20187 VB denotes infiltrating
T9455 20188-20191 DT denotes the
T9456 20192-20196 NN denotes bone
T9457 20197-20203 NN denotes marrow
T9458 20204-20206 IN denotes of
T9459 20207-20211 NN denotes mice
T9460 20212-20216 IN denotes with
T9461 20217-20229 JJ denotes inflammatory
T9462 20230-20239 NN denotes arthritis
T9463 20240-20241 -LRB- denotes [
T9464 20241-20243 CD denotes 43
T9465 20243-20244 -RRB- denotes ]
T9466 20246-20248 IN denotes In
T9467 20249-20253 DT denotes this
T9468 20254-20259 NN denotes study
T9469 20259-20260 -COMMA- denotes ,
T9470 20261-20262 DT denotes a
T9471 20263-20267 NN denotes role
T9472 20268-20271 IN denotes for
T9473 20272-20276 NN denotes BMPs
T9474 20277-20279 IN denotes in
T9475 20280-20283 DT denotes the
T9476 20284-20297 JJ denotes inflammatoric
T9477 20298-20305 NN denotes process
T9478 20306-20308 IN denotes of
T9479 20309-20318 NN denotes arthritis
T9480 20319-20322 VB denotes was
T9481 20323-20332 VB denotes suggested
T9482 20334-20337 DT denotes The
T9483 20338-20350 NN denotes upregulation
T9484 20351-20353 IN denotes of
T9485 20354-20357 DT denotes the
T9486 20358-20375 NN denotes BMP-6-transcripts
T9487 20376-20381 IN denotes after
T9488 20382-20398 NN denotes IgM-crosslinking
T9489 20399-20401 VB denotes is
T9490 20402-20404 IN denotes of
T9491 20405-20421 JJ denotes pathophysiologic
T9492 20422-20430 NN denotes interest
T9493 20431-20432 -LRB- denotes [
T9494 20432-20434 CD denotes 12
T9495 20434-20435 -RRB- denotes ]
T9496 20437-20438 DT denotes A
T9497 20439-20443 NN denotes loss
T9498 20444-20446 IN denotes of
T9499 20447-20467 NN denotes TGF-β-responsiveness
T9500 20468-20471 VB denotes has
T9501 20472-20476 VB denotes been
T9502 20477-20486 VB denotes suggested
T9503 20487-20489 TO denotes to
T9504 20490-20492 VB denotes be
T9505 20493-20494 DT denotes a
T9506 20495-20503 JJ denotes critical
T9507 20504-20516 NN denotes contribution
T9508 20517-20519 TO denotes to
T9509 20520-20529 JJ denotes malignant
T9510 20530-20544 NN denotes transformation
T9511 20545-20546 -LRB- denotes [
T9512 20546-20551 CD denotes 47,48
T9513 20551-20552 -RRB- denotes ]
T9514 20553-20556 CC denotes and
T9515 20557-20564 JJ denotes similar
T9516 20565-20574 JJ denotes oncogenic
T9517 20575-20585 NN denotes mechanisms
T9518 20586-20590 VB denotes have
T9519 20591-20595 VB denotes been
T9520 20596-20606 VB denotes postulated
T9521 20607-20610 IN denotes for
T9522 20611-20615 NN denotes BMPs
T9523 20617-20622 NN denotes Lines
T9524 20623-20625 IN denotes of
T9525 20626-20634 NN denotes evidence
T9526 20635-20642 VB denotes suggest
T9527 20643-20644 -LRB- denotes [
T9528 20644-20646 CD denotes 49
T9529 20646-20647 -RRB- denotes ]
T9530 20648-20652 IN denotes that
T9531 20653-20655 IN denotes at
T9532 20656-20661 JJ denotes early
T9533 20662-20668 NN denotes stages
T9534 20669-20671 IN denotes of
T9535 20672-20686 NN denotes carcinogenesis
T9536 20686-20687 -COMMA- denotes ,
T9537 20688-20693 NN denotes BMP-6
T9538 20694-20696 VB denotes is
T9539 20697-20700 RB denotes not
T9540 20701-20702 DT denotes a
T9541 20703-20709 NN denotes tumour
T9542 20710-20718 NN denotes promoter
T9543 20718-20719 -COMMA- denotes ,
T9544 20720-20723 CC denotes but
T9545 20724-20734 VB denotes suppresses
T9546 20735-20741 JJ denotes benign
T9547 20742-20745 CC denotes and
T9548 20746-20755 JJ denotes malignant
T9549 20756-20762 NN denotes tumour
T9550 20763-20772 NN denotes outgrowth
T9551 20774-20779 DT denotes These
T9552 20780-20788 NN denotes findings
T9553 20789-20792 VB denotes are
T9554 20793-20795 IN denotes in
T9555 20796-20800 JJ denotes good
T9556 20801-20810 NN denotes agreement
T9557 20811-20815 IN denotes with
T9558 20816-20824 JJ denotes previous
T9559 20825-20833 NN denotes findings
T9560 20834-20837 IN denotes for
T9561 20838-20843 JJ denotes other
T9562 20844-20849 NN denotes TGF-β
T9563 20850-20856 NN denotes family
T9564 20857-20864 NN denotes members
T9565 20864-20865 -COMMA- denotes ,
T9566 20866-20875 VB denotes including
T9567 20876-20882 NN denotes TGF-β1
T9568 20883-20886 CC denotes and
T9569 20887-20892 NN denotes BMP-4
T9570 20893-20894 -LRB- denotes [
T9571 20894-20896 CD denotes 50
T9572 20896-20897 -RRB- denotes ]
T9573 20897-20898 -COMMA- denotes ,
T9574 20899-20909 VB denotes indicating
T9575 20910-20914 IN denotes that
T9576 20915-20923 JJ denotes cellular
T9577 20924-20931 NN denotes context
T9578 20932-20934 IN denotes of
T9579 20935-20938 DT denotes the
T9580 20939-20942 NN denotes BMP
T9581 20943-20949 NN denotes target
T9582 20950-20954 NN denotes cell
T9583 20955-20960 MD denotes might
T9584 20961-20967 VB denotes define
T9585 20968-20971 DT denotes the
T9586 20972-20979 JJ denotes various
T9587 20980-20988 VB denotes observed
T9588 20989-20996 NN denotes effects
T9589 20998-21000 IN denotes In
T9590 21001-21009 NN denotes contrast
T9591 21010-21012 TO denotes to
T9592 21013-21016 DT denotes the
T9593 21017-21029 NN denotes upregulation
T9594 21030-21032 IN denotes of
T9595 21033-21038 NN denotes BMP-6
T9596 21039-21049 NN denotes transcript
T9597 21050-21052 IN denotes in
T9598 21053-21054 NN denotes B
T9599 21055-21060 NN denotes cells
T9600 21060-21061 -COMMA- denotes ,
T9601 21062-21064 PRP denotes we
T9602 21065-21069 VB denotes were
T9603 21070-21073 RB denotes not
T9604 21074-21078 JJ denotes able
T9605 21079-21081 TO denotes to
T9606 21082-21088 VB denotes detect
T9607 21089-21094 NN denotes BMP-6
T9608 21095-21106 NN denotes transcripts
T9609 21107-21109 IN denotes in
T9610 21110-21115 JJ denotes human
T9611 21116-21126 JJ denotes peripheral
T9612 21127-21132 NN denotes blood
T9613 21133-21137 JJ denotes CD4+
T9614 21138-21140 CC denotes or
T9615 21141-21145 JJ denotes CD8+
T9616 21146-21147 NN denotes T
T9617 21148-21153 NN denotes cells
T9618 21154-21155 -LRB- denotes (
T9619 21155-21162 VB denotes resting
T9620 21163-21165 CC denotes or
T9621 21166-21176 VB denotes stimulated
T9622 21177-21181 IN denotes with
T9623 21182-21190 JJ denotes anti-CD3
T9624 21191-21194 CC denotes and
T9625 21195-21204 JJ denotes anti-CD28
T9626 21204-21205 -COLON- denotes ;
T9627 21206-21210 NN denotes data
T9628 21211-21214 RB denotes not
T9629 21215-21220 VB denotes shown
T9630 21220-21221 -RRB- denotes )
T9631 21221-21222 -COMMA- denotes ,
T9632 21223-21233 JJ denotes consistent
T9633 21234-21238 IN denotes with
T9634 21239-21242 DT denotes the
T9635 21243-21251 NN denotes findings
T9636 21252-21254 IN denotes in
T9637 21255-21256 NN denotes T
T9638 21257-21261 NN denotes cell
T9639 21262-21267 NN denotes lines
T9640 21268-21269 -LRB- denotes [
T9641 21269-21271 CD denotes 20
T9642 21271-21272 -RRB- denotes ]
T9643 21273-21276 CC denotes and
T9644 21277-21278 NN denotes T
T9645 21279-21284 NN denotes cells
T9646 21285-21287 IN denotes in
T9647 21288-21292 NN denotes mice
T9648 21293-21294 -LRB- denotes [
T9649 21294-21296 CD denotes 43
T9650 21296-21297 -RRB- denotes ]
T9651 21299-21304 JJ denotes Other
T9652 21305-21314 JJ denotes potential
T9653 21315-21320 NN denotes BMP-6
T9654 21321-21328 NN denotes sources
T9655 21329-21332 IN denotes for
T9656 21333-21339 JJ denotes mature
T9657 21340-21341 NN denotes B
T9658 21342-21347 NN denotes cells
T9659 21348-21350 FW denotes in
T9660 21351-21355 FW denotes vivo
T9661 21356-21361 MD denotes might
T9662 21362-21364 VB denotes be
T9663 21365-21370 JJ denotes other
T9664 21371-21376 NN denotes cells
T9665 21377-21379 IN denotes of
T9666 21380-21383 DT denotes the
T9667 21384-21390 JJ denotes immune
T9668 21391-21397 NN denotes system
T9669 21398-21400 CC denotes or
T9670 21401-21407 NN denotes tissue
T9671 21408-21412 IN denotes with
T9672 21413-21420 NN denotes contact
T9673 21421-21423 TO denotes to
T9674 21424-21427 DT denotes the
T9675 21428-21441 JJ denotes hematopoietic
T9676 21442-21448 NN denotes system
T9677 21450-21453 CD denotes One
T9678 21454-21458 RB denotes well
T9679 21459-21469 VB denotes recognized
T9680 21470-21476 NN denotes source
T9681 21477-21480 IN denotes for
T9682 21481-21486 NN denotes BMP-6
T9683 21487-21497 NN denotes production
T9684 21498-21500 VB denotes is
T9685 21501-21504 DT denotes the
T9686 21505-21510 JJ denotes human
T9687 21511-21515 NN denotes bone
T9688 21516-21519 CC denotes and
T9689 21520-21524 NN denotes bone
T9690 21525-21531 NN denotes marrow
T9691 21532-21538 NN denotes stroma
T9692 21539-21540 -LRB- denotes [
T9693 21540-21544 CD denotes 51,8
T9694 21544-21545 -RRB- denotes ]
T9695 21547-21558 RB denotes Furthermore
T9696 21558-21559 -COMMA- denotes ,
T9697 21560-21562 PRP denotes it
T9698 21563-21565 VB denotes is
T9699 21566-21576 JJ denotes noteworthy
T9700 21577-21581 IN denotes that
T9701 21582-21587 JJ denotes human
T9702 21588-21597 JJ denotes umbilical
T9703 21598-21602 NN denotes vein
T9704 21603-21614 JJ denotes endothelial
T9705 21615-21620 NN denotes cells
T9706 21621-21622 -LRB- denotes (
T9707 21622-21627 NN denotes HUVEC
T9708 21627-21628 -RRB- denotes )
T9709 21629-21635 RB denotes highly
T9710 21636-21643 VB denotes express
T9711 21644-21649 NN denotes BMP-6
T9712 21650-21654 NN denotes mRNA
T9713 21655-21656 -LRB- denotes [
T9714 21656-21658 CD denotes 52
T9715 21658-21659 -RRB- denotes ]
T9716 21659-21660 -COMMA- denotes ,
T9717 21661-21664 CC denotes and
T9718 21665-21673 JJ denotes vascular
T9719 21674-21685 NN denotes endothelium
T9720 21686-21689 VB denotes has
T9721 21690-21694 VB denotes been
T9722 21695-21703 VB denotes reported
T9723 21704-21706 TO denotes to
T9724 21707-21714 VB denotes produce
T9725 21715-21720 NN denotes BMP-6
T9726 21721-21722 -LRB- denotes [
T9727 21722-21724 CD denotes 53
T9728 21724-21725 -RRB- denotes ]
T9729 21727-21732 DT denotes These
T9730 21733-21740 NN denotes studies
T9731 21741-21746 MD denotes might
T9732 21747-21752 VB denotes imply
T9733 21753-21754 DT denotes a
T9734 21755-21759 NN denotes role
T9735 21760-21763 IN denotes for
T9736 21764-21769 NN denotes BMP-6
T9737 21770-21772 IN denotes in
T9738 21773-21789 JJ denotes transendothelial
T9739 21790-21799 NN denotes migration
T9740 21800-21802 IN denotes of
T9741 21803-21804 NN denotes B
T9742 21805-21810 NN denotes cells
T9743 21812-21817 NN denotes BMP-6
T9744 21818-21822 NN denotes mRNA
T9745 21823-21826 VB denotes has
T9746 21827-21831 VB denotes been
T9747 21832-21844 VB denotes demonstrated
T9748 21845-21847 IN denotes in
T9749 21848-21854 JJ denotes murine
T9750 21855-21865 NN denotes macrophage
T9751 21866-21870 NN denotes cell
T9752 21871-21876 NN denotes lines
T9753 21876-21877 -COMMA- denotes ,
T9754 21878-21881 CC denotes but
T9755 21882-21885 RB denotes not
T9756 21886-21888 IN denotes in
T9757 21889-21895 NN denotes humans
T9758 21896-21897 -LRB- denotes [
T9759 21897-21899 CD denotes 54
T9760 21899-21900 -RRB- denotes ]
T9761 21902-21904 IN denotes In
T9762 21905-21915 NN denotes accordance
T9763 21916-21920 IN denotes with
T9764 21921-21926 DT denotes these
T9765 21927-21935 NN denotes findings
T9766 21935-21936 -COMMA- denotes ,
T9767 21937-21942 JJ denotes other
T9768 21943-21948 JJ denotes human
T9769 21949-21953 NN denotes cell
T9770 21954-21959 NN denotes lines
T9772 21963-21973 NN denotes neutrophil
T9773 21974-21977 CC denotes and
T9774 21978-21987 JJ denotes monocytic
T9775 21988-21994 NN denotes origin
T9776 21995-21999 VB denotes have
T9777 22000-22004 VB denotes been
T9778 22005-22014 VB denotes described
T9779 22015-22017 TO denotes to
T9780 22018-22020 VB denotes be
T9781 22021-22029 JJ denotes negative
T9782 22030-22033 IN denotes for
T9783 22034-22037 DT denotes the
T9784 22038-22043 NN denotes BMP-6
T9785 22044-22054 NN denotes transcript
T9786 22055-22056 -LRB- denotes [
T9787 22056-22058 CD denotes 20
T9788 22058-22059 -RRB- denotes ]
T9789 22061-22063 TO denotes To
T9790 22064-22067 PRP-DOLLAR- denotes our
T9791 22068-22077 NN denotes knowledge
T9792 22077-22078 -COMMA- denotes ,
T9793 22079-22084 EX denotes there
T9794 22085-22087 VB denotes is
T9795 22088-22097 RB denotes currently
T9796 22098-22100 DT denotes no
T9797 22101-22107 NN denotes report
T9798 22108-22113 IN denotes about
T9799 22114-22119 NN denotes BMP-6
T9800 22120-22130 NN denotes production
T9801 22131-22133 IN denotes of
T9802 22134-22139 JJ denotes human
T9803 22140-22149 JJ denotes dendritic
T9804 22150-22155 NN denotes cells
T13413 22169-22171 IN denotes In
T13414 22172-22182 NN denotes conclusion
T13415 22182-22183 -COMMA- denotes ,
T13416 22184-22187 PRP-DOLLAR- denotes our
T13417 22188-22195 NN denotes results
T13418 22196-22200 VB denotes show
T13419 22201-22205 IN denotes that
T13420 22206-22211 NN denotes BMP-6
T13421 22212-22219 VB denotes induces
T13422 22220-22230 NN denotes activation
T13423 22231-22233 IN denotes of
T13424 22234-22247 JJ denotes intracellular
T13425 22248-22252 NN denotes Smad
T13426 22253-22263 NN denotes signalling
T13427 22264-22266 IN denotes in
T13428 22267-22273 JJ denotes mature
T13429 22274-22279 JJ denotes human
T13430 22280-22287 NN denotes B-cells
T13431 22288-22292 IN denotes with
T13432 22293-22304 JJ denotes consecutive
T13433 22305-22315 NN denotes production
T13434 22316-22318 IN denotes of
T13435 22319-22322 NN denotes Id1
T13436 22323-22330 NN denotes protein
T13437 22332-22343 RB denotes Furthermore
T13438 22343-22344 -COMMA- denotes ,
T13439 22345-22347 PRP denotes we
T13440 22348-22354 VB denotes report
T13441 22355-22359 IN denotes that
T13442 22360-22365 NN denotes BMP-6
T13443 22366-22369 VB denotes has
T13444 22370-22372 DT denotes an
T13445 22373-22390 JJ denotes antiproliferative
T13446 22391-22397 NN denotes effect
T13447 22398-22400 IN denotes in
T13448 22401-22402 NN denotes B
T13449 22403-22408 NN denotes cells
T13450 22409-22419 VB denotes stimulated
T13451 22420-22424 IN denotes with
T13452 22425-22433 NN denotes anti-IgM
T13453 22434-22439 RB denotes alone
T13454 22440-22442 CC denotes or
T13455 22443-22446 DT denotes the
T13456 22447-22455 VB denotes combined
T13457 22456-22462 NN denotes action
T13458 22463-22465 IN denotes of
T13459 22466-22474 JJ denotes anti-IgM
T13460 22475-22478 CC denotes and
T13461 22479-22484 NN denotes CD40L
T13462 22486-22498 RB denotes Additionally
T13463 22498-22499 -COMMA- denotes ,
T13464 22500-22505 NN denotes BMP-6
T13465 22506-22513 VB denotes induces
T13466 22514-22518 NN denotes cell
T13467 22519-22524 NN denotes death
T13468 22525-22527 IN denotes in
T13469 22528-22537 VB denotes activated
T13470 22538-22544 NN denotes memory
T13471 22545-22546 NN denotes B
T13472 22547-22552 NN denotes cells
T13473 22553-22556 CC denotes and
T13474 22557-22562 NN denotes Ramos
T13475 22563-22568 NN denotes cells
T13476 22570-22575 VB denotes Taken
T13477 22576-22584 RB denotes together
T13478 22584-22585 -COMMA- denotes ,
T13479 22586-22591 DT denotes these
T13480 22592-22599 NN denotes results
T13481 22600-22607 VB denotes provide
T13482 22608-22609 DT denotes a
T13483 22610-22619 NN denotes rationale
T13484 22620-22622 TO denotes to
T13485 22623-22630 RB denotes further
T13486 22631-22638 VB denotes examine
T13487 22639-22642 DT denotes the
T13488 22643-22647 NN denotes role
T13489 22648-22650 IN denotes of
T13490 22651-22656 NN denotes BMP-6
T13491 22657-22667 NN denotes signalling
T13492 22668-22670 IN denotes in
T13493 22671-22677 JJ denotes normal
T13494 22678-22679 NN denotes B
T13495 22680-22684 NN denotes cell
T13496 22685-22692 NN denotes biology
T13497 22693-22695 RB denotes as
T13498 22696-22700 RB denotes well
T13499 22701-22703 IN denotes as
T13500 22704-22706 IN denotes in
T13501 22707-22717 JJ denotes pathologic
T13502 22718-22728 NN denotes conditions
T13503 22729-22733 IN denotes like
T13504 22734-22735 NN denotes B
T13505 22736-22740 NN denotes cell
T13506 22741-22753 NN denotes malignancies
T13507 22754-22757 CC denotes and
T13508 22758-22768 JJ denotes autoimmune
T13509 22769-22778 NN denotes disorders
T13708 22790-22794 NN denotes Cell
T13709 22795-22802 NN denotes culture
T13710 22803-22805 IN denotes If
T13711 22806-22809 RB denotes not
T13712 22810-22819 VB denotes specified
T13713 22819-22820 -COMMA- denotes ,
T13714 22821-22824 DT denotes all
T13715 22825-22830 NN denotes cells
T13716 22831-22835 VB denotes were
T13717 22836-22844 VB denotes cultured
T13718 22845-22847 IN denotes in
T13719 22848-22854 NN denotes X-VIVO
T13720 22855-22858 CD denotes 15™
T13721 22859-22860 -LRB- denotes (
T13722 22860-22872 NNP denotes BioWhittaker
T13723 22872-22873 -COMMA- denotes ,
T13724 22874-22882 NNP denotes Verviers
T13725 22882-22883 -COMMA- denotes ,
T13726 22884-22891 NNP denotes Belgium
T13727 22891-22892 -RRB- denotes )
T13728 22893-22903 JJ denotes serum-free
T13729 22904-22910 NN denotes medium
T13730 22911-22913 IN denotes at
T13731 22914-22918 NN denotes 37°C
T13732 22919-22922 CC denotes and
T13733 22923-22924 CD denotes 5
T13734 22924-22925 NN denotes %
T13735 22926-22929 NN denotes CO2
T13736 22930-22932 IN denotes in
T13737 22933-22936 NN denotes air
T13738 22938-22948 JJ denotes Peripheral
T13739 22949-22954 NN denotes blood
T13740 22955-22958 VB denotes was
T13741 22959-22967 VB denotes provided
T13742 22968-22970 IN denotes by
T13743 22971-22974 DT denotes the
T13744 22975-22980 NNP denotes Blood
T13745 22981-22985 NNP denotes Bank
T13746 22986-22988 IN denotes at
T13747 22989-22997 NNP denotes Buskerud
T13748 22998-23006 NNP denotes Regional
T13749 23007-23015 NNP denotes Hospital
T13750 23016-23020 IN denotes with
T13751 23021-23027 JJ denotes formal
T13752 23028-23037 NN denotes agreement
T13753 23038-23040 IN denotes by
T13754 23041-23044 DT denotes the
T13755 23045-23053 NN denotes patients
T13756 23053-23054 -COMMA- denotes ,
T13757 23055-23058 CC denotes and
T13758 23059-23067 NN denotes approval
T13759 23068-23070 IN denotes by
T13760 23071-23074 DT denotes the
T13761 23075-23083 JJ denotes regional
T13762 23084-23090 NN denotes ethics
T13763 23091-23100 NN denotes committee
T13764 23102-23108 RB denotes Highly
T13765 23109-23117 VB denotes purified
T13766 23118-23125 VB denotes resting
T13767 23126-23131 JJ denotes human
T13768 23132-23145 NN denotes B-lymphocytes
T13769 23146-23147 -LRB- denotes (
T13770 23147-23152 JJ denotes CD19+
T13771 23153-23158 NN denotes cells
T13772 23158-23159 -RRB- denotes )
T13773 23160-23164 VB denotes were
T13774 23165-23173 VB denotes isolated
T13775 23174-23178 IN denotes from
T13776 23179-23182 DT denotes the
T13777 23183-23193 JJ denotes peripheral
T13778 23194-23199 NN denotes blood
T13779 23200-23202 IN denotes by
T13780 23203-23212 VB denotes rosetting
T13781 23213-23217 IN denotes with
T13782 23218-23232 JJ denotes immunomagnetic
T13783 23233-23238 NN denotes beads
T13784 23239-23240 -LRB- denotes (
T13785 23240-23249 NN denotes Dynabeads
T13786 23250-23254 NN denotes M450
T13787 23254-23255 -COLON- denotes ;
T13788 23256-23261 NNP denotes Dynal
T13789 23261-23262 -COMMA- denotes ,
T13790 23263-23267 NNP denotes Oslo
T13791 23267-23268 -COMMA- denotes ,
T13792 23269-23275 NNP denotes Norway
T13793 23275-23276 -RRB- denotes )
T13794 23277-23279 IN denotes as
T13795 23280-23289 VB denotes described
T13796 23290-23291 -LRB- denotes [
T13797 23291-23293 CD denotes 55
T13798 23293-23294 -RRB- denotes ]
T13799 23296-23300 DT denotes This
T13800 23301-23310 NN denotes procedure
T13801 23311-23317 VB denotes yields
T13802 23318-23322 JJ denotes less
T13803 23323-23327 IN denotes than
T13804 23328-23331 CD denotes 0.5
T13805 23331-23332 NN denotes %
T13806 23333-23334 NN denotes T
T13807 23335-23340 NN denotes cells
T13808 23340-23341 -COMMA- denotes ,
T13809 23342-23345 CD denotes 0.1
T13810 23345-23346 NN denotes %
T13811 23347-23349 NN denotes NK
T13812 23350-23355 NN denotes cells
T13813 23355-23356 -COMMA- denotes ,
T13814 23357-23360 CC denotes and
T13815 23361-23364 CD denotes 0.5
T13816 23364-23365 NN denotes %
T13817 23366-23375 NN denotes monocytes
T13818 23376-23378 IN denotes as
T13819 23379-23385 VB denotes judged
T13820 23386-23388 IN denotes by
T13821 23389-23397 JJ denotes indirect
T13822 23398-23416 NN denotes immunofluorescence
T13823 23417-23425 NN denotes staining
T13824 23427-23430 DT denotes The
T13825 23431-23440 VB denotes following
T13826 23441-23445 NN denotes cell
T13827 23446-23451 NN denotes lines
T13828 23452-23456 IN denotes from
T13829 23457-23462 JJ denotes human
T13830 23463-23471 JJ denotes lymphoid
T13831 23472-23484 NN denotes malignancies
T13832 23485-23489 VB denotes were
T13833 23490-23500 VB denotes maintained
T13834 23501-23503 IN denotes in
T13835 23504-23508 NN denotes RPMI
T13836 23509-23513 CD denotes 1640
T13837 23514-23515 -LRB- denotes (
T13838 23515-23518 NN denotes PAA
T13839 23519-23531 NNP denotes Laboratories
T13840 23532-23536 NNP denotes GmbH
T13841 23536-23537 -COMMA- denotes ,
T13842 23538-23546 NNP denotes Pasching
T13843 23546-23547 -COMMA- denotes ,
T13844 23548-23555 NNP denotes Austria
T13845 23555-23556 -RRB- denotes )
T13846 23557-23569 VB denotes supplemented
T13847 23570-23574 IN denotes with
T13848 23575-23577 CD denotes 10
T13849 23577-23578 NN denotes %
T13850 23579-23585 JJ denotes foetal
T13851 23586-23592 JJ denotes bovine
T13852 23593-23598 NN denotes serum
T13853 23599-23600 -LRB- denotes (
T13854 23600-23603 NN denotes FCS
T13855 23603-23604 -RRB- denotes )
T13856 23604-23605 -COMMA- denotes ,
T13857 23606-23609 CD denotes 100
T13858 23610-23618 NN denotes units/ml
T13859 23619-23629 NN denotes penicillin
T13860 23630-23631 NN denotes G
T13861 23631-23632 -COMMA- denotes ,
T13862 23633-23636 CC denotes and
T13863 23637-23640 CD denotes 100
T13864 23641-23649 NN denotes units/ml
T13865 23650-23652 IN denotes of
T13866 23653-23665 NN denotes streptomycin
T13867 23666-23674 NN denotes sulphate
T13868 23674-23675 -COMMA- denotes ,
T13869 23676-23679 CC denotes but
T13870 23680-23693 JJ denotes serum-starved
T13871 23694-23697 IN denotes for
T13872 23698-23700 IN denotes at
T13873 23701-23706 JJ denotes least
T13874 23707-23711 CD denotes four
T13875 23712-23717 NN denotes hours
T13876 23718-23721 CC denotes and
T13877 23722-23730 VB denotes cultured
T13878 23731-23733 IN denotes in
T13879 23734-23740 NN denotes X-VIVO
T13880 23741-23744 CD denotes 15™
T13881 23745-23749 WRB denotes when
T13882 23750-23758 VB denotes included
T13883 23759-23761 IN denotes in
T13884 23762-23773 NN denotes experiments
T13885 23773-23774 -COLON- denotes :
T13886 23775-23787 JJ denotes EBV-negative
T13887 23788-23790 NN denotes BL
T13888 23791-23795 NN denotes cell
T13889 23796-23801 NN denotes lines
T13890 23802-23807 NN denotes Ramos
T13891 23808-23809 -LRB- denotes (
T13892 23809-23814 NN denotes ECACC
T13893 23815-23823 CD denotes 85030802
T13894 23823-23824 -RRB- denotes )
T13895 23824-23825 -COMMA- denotes ,
T13896 23826-23830 NN denotes HL60
T13897 23831-23832 -LRB- denotes (
T13898 23832-23840 NN denotes JCRB0085
T13899 23840-23841 -RRB- denotes )
T14428 24387-24397 NN denotes Antibodies
T14429 24398-24402 VB denotes used
T14430 24403-24406 IN denotes for
T14431 24407-24411 NN denotes flow
T14432 24412-24422 JJ denotes cytometric
T14433 24423-24431 NN denotes analysis
T14434 24432-24435 CC denotes and
T14435 24436-24446 NN denotes immunoblot
T14436 24447-24455 NN denotes analysis
T14437 24456-24466 NN denotes Antibodies
T14438 24467-24474 IN denotes against
T14439 24475-24478 DT denotes the
T14440 24479-24484 JJ denotes human
T14441 24485-24498 NN denotes BMP-receptors
T14442 24499-24506 NN denotes Act-RIA
T14443 24506-24507 -COMMA- denotes ,
T14444 24508-24515 NN denotes BMP-RIB
T14445 24515-24516 -COMMA- denotes ,
T14446 24517-24524 NN denotes BMPR-II
T14447 24524-24525 -COMMA- denotes ,
T14448 24526-24534 NN denotes Act-RIIA
T14449 24535-24538 CC denotes and
T14450 24539-24547 NN denotes Act-RIIb
T14451 24548-24552 VB denotes were
T14452 24553-24562 VB denotes purchased
T14453 24563-24567 IN denotes from
T14454 24568-24569 NNP denotes R
T14455 24570-24571 CC denotes &
T14456 24572-24573 NNP denotes D
T14457 24574-24581 NNP denotes Systems
T14458 24582-24583 -LRB- denotes (
T14459 24583-24591 NNP denotes Abingdon
T14460 24591-24592 -COMMA- denotes ,
T14461 24593-24595 NNP denotes UK
T14462 24595-24596 -RRB- denotes )
T14463 24598-24607 NN denotes Detection
T14464 24608-24610 IN denotes of
T14465 24611-24614 DT denotes the
T14466 24615-24628 NN denotes BMP-6-protein
T14467 24629-24632 VB denotes has
T14468 24633-24637 VB denotes been
T14469 24638-24643 VB denotes tried
T14470 24644-24648 IN denotes with
T14471 24649-24652 DT denotes the
T14472 24653-24662 VB denotes following
T14473 24663-24673 NN denotes antibodies
T14474 24673-24674 -COLON- denotes :
T14475 24675-24679 NN denotes goat
T14476 24680-24690 JJ denotes polyclonal
T14477 24691-24701 NN denotes anti-BMP-6
T14478 24702-24703 -LRB- denotes (
T14479 24703-24708 NNP denotes Santa
T14480 24709-24713 NNP denotes Cruz
T14481 24713-24714 -COMMA- denotes ,
T14482 24715-24718 NNP denotes San
T14483 24719-24724 NNP denotes Diego
T14484 24724-24725 -COMMA- denotes ,
T14485 24726-24728 NNP denotes CA
T14486 24728-24729 -COMMA- denotes ,
T14487 24730-24733 NNP denotes USA
T14488 24733-24734 -RRB- denotes )
T14489 24734-24735 -COMMA- denotes ,
T14490 24736-24746 JJ denotes monoclonal
T14491 24747-24752 NN denotes mouse
T14492 24753-24763 NN denotes anti-BMP-6
T14493 24764-24767 CC denotes and
T14494 24768-24778 JJ denotes polyclonal
T14495 24779-24783 NN denotes goat
T14496 24784-24794 NN denotes anti-BMP-6
T14497 24795-24799 IN denotes from
T14498 24800-24801 NNP denotes R
T14499 24802-24803 CC denotes &
T14500 24804-24805 NNP denotes D
T14501 24806-24813 NNP denotes Systems
T14502 24814-24815 -LRB- denotes (
T14503 24815-24823 NNP denotes Abingdon
T14504 24823-24824 -COMMA- denotes ,
T14505 24825-24827 NNP denotes UK
T14506 24827-24828 -RRB- denotes )
T14507 24828-24829 -COMMA- denotes ,
T14508 24830-24833 CC denotes and
T14509 24834-24839 NN denotes mouse
T14510 24840-24850 JJ denotes monoclonal
T14511 24851-24861 JJ denotes anti-BMP-6
T14512 24862-24863 -LRB- denotes (
T14513 24863-24871 NNP denotes Chemicon
T14514 24872-24885 NNP denotes International
T14515 24886-24889 NNP denotes Inc
T14516 24889-24890 -COMMA- denotes ,
T14517 24891-24899 NNP denotes Temecula
T14518 24899-24900 -COMMA- denotes ,
T14519 24901-24903 NNP denotes CA
T14520 24903-24904 -COMMA- denotes ,
T14521 24905-24908 NNP denotes USA
T14522 24908-24909 -RRB- denotes )
T14523 24911-24927 NN denotes Characterisation
T14524 24928-24930 IN denotes of
T14525 24931-24945 JJ denotes BMP-signalling
T14526 24946-24954 NN denotes pathways
T14527 24955-24958 VB denotes was
T14528 24959-24963 VB denotes done
T14529 24964-24966 IN denotes by
T14530 24967-24970 NN denotes use
T14531 24971-24973 IN denotes of
T14532 24974-24992 NN denotes anti-phospho-Smad1
T14533 24992-24993 -COMMA- denotes ,
T14534 24994-24996 CD denotes -5
T14535 24996-24997 -COMMA- denotes ,
T14536 24998-25002 JJ denotes -and
T14537 25003-25004 CD denotes 8
T14538 25005-25015 JJ denotes polyclonal
T14539 25016-25024 NN denotes antibody
T14540 25025-25026 -LRB- denotes (
T14541 25026-25034 NNP denotes Chemicon
T14542 25034-25035 -COMMA- denotes ,
T14543 25036-25044 NNP denotes Temecula
T14544 25044-25045 -COMMA- denotes ,
T14545 25046-25048 NNP denotes CA
T14546 25048-25049 -COMMA- denotes ,
T14547 25050-25053 NNP denotes USA
T14548 25053-25054 -RRB- denotes )
T14549 25056-25066 NN denotes Expression
T14550 25067-25073 NN denotes levels
T14551 25074-25076 IN denotes of
T14552 25077-25082 NN denotes Id1–3
T14553 25083-25091 NN denotes proteins
T14554 25092-25096 VB denotes were
T14555 25097-25105 VB denotes detected
T14556 25106-25110 IN denotes with
T14557 25111-25121 JJ denotes polyclonal
T14558 25122-25128 NN denotes rabbit
T14559 25129-25137 NN denotes antibody
T14560 25138-25141 CC denotes and
T14561 25142-25151 NN denotes detection
T14562 25152-25155 VB denotes was
T14563 25156-25163 VB denotes blocked
T14564 25164-25168 IN denotes with
T14565 25169-25177 VB denotes blocking
T14566 25178-25185 NN denotes peptide
T14567 25186-25190 IN denotes from
T14568 25191-25196 NNP denotes Santa
T14569 25197-25201 NNP denotes Cruz
T14570 25202-25215 NNP denotes Biotechnology
T14571 25216-25217 -LRB- denotes (
T14572 25217-25222 NNP denotes Santa
T14573 25223-25227 NNP denotes Cruz
T14574 25227-25228 -COMMA- denotes ,
T14575 25229-25232 NNP denotes San
T14576 25233-25238 NNP denotes Diego
T14577 25238-25239 -COMMA- denotes ,
T14578 25240-25242 NNP denotes CA
T14579 25242-25243 -COMMA- denotes ,
T14580 25244-25247 NNP denotes USA
T14581 25247-25248 -RRB- denotes )
T14582 25250-25252 IN denotes As
T14583 25253-25262 JJ denotes secondary
T14584 25263-25273 NN denotes antibodies
T14585 25274-25280 VB denotes served
T14586 25281-25291 JJ denotes anti-mouse
T14587 25291-25292 -COMMA- denotes ,
T14588 25293-25302 JJ denotes anti-goat
T14589 25303-25305 CC denotes or
T14590 25306-25317 JJ denotes anti-rabbit
T14591 25318-25322 NN denotes IgG-
T14592 25323-25334 NN denotes horseradish
T14593 25335-25345 NN denotes peroxidase
T14594 25346-25347 -LRB- denotes (
T14595 25347-25350 NN denotes HRP
T14596 25350-25351 -RRB- denotes )
T14597 25352-25356 IN denotes from
T14598 25357-25371 NN denotes Dakocytomation
T14599 25372-25374 NN denotes AS
T14600 25375-25376 -LRB- denotes (
T14601 25376-25386 NN denotes Copenhagen
T14602 25386-25387 -COMMA- denotes ,
T14603 25388-25395 NNP denotes Denmark
T14604 25395-25396 -RRB- denotes )
T14605 25397-25400 IN denotes for
T14606 25401-25411 NN denotes immunoblot
T14607 25412-25420 NN denotes analysis
T14608 25422-25434 NN denotes Anti-β-actin
T14609 25435-25438 VB denotes was
T14610 25439-25443 IN denotes from
T14611 25444-25455 NNP denotes Santa-Cruz.
T14612 25456-25460 NNP denotes From
T14613 25461-25467 NNP denotes Becton
T14614 25468-25477 NNP denotes Dickinson
T14615 25478-25479 -LRB- denotes (
T14616 25479-25482 NNP denotes San
T14617 25483-25487 NNP denotes Jose
T14618 25487-25488 -COMMA- denotes ,
T14619 25489-25491 NNP denotes CA
T14620 25491-25492 -RRB- denotes )
T14621 25492-25493 -COMMA- denotes ,
T14622 25494-25496 PRP denotes we
T14623 25497-25506 VB denotes purchased
T14624 25507-25519 JJ denotes anti-CD19-PE
T14625 25519-25520 -COMMA- denotes ,
T14626 25521-25535 NN denotes anti-CD19-FITC
T14627 25537-25540 DT denotes The
T14628 25541-25551 NN denotes antibodies
T14629 25552-25556 VB denotes used
T14630 25557-25560 IN denotes for
T14631 25561-25565 NN denotes cell
T14632 25566-25573 NN denotes sorting
T14633 25574-25578 VB denotes were
T14634 25579-25588 JJ denotes anti-CD19
T14635 25589-25592 NN denotes PC5
T14636 25593-25597 IN denotes from
T14637 25598-25608 NNP denotes Immunotech
T14638 25609-25611 NNP denotes SA
T14639 25612-25613 -LRB- denotes (
T14640 25613-25622 NNP denotes Marseille
T14641 25622-25623 -COMMA- denotes ,
T14642 25624-25630 NNP denotes France
T14643 25630-25631 -RRB- denotes )
T14644 25632-25635 CC denotes and
T14645 25636-25645 JJ denotes anti-CD27
T14646 25646-25648 NN denotes PE
T14647 25649-25653 IN denotes from
T14648 25654-25660 NNP denotes Becton
T14649 25661-25670 NNP denotes Dickinson
T14650 25670-25671 -COMMA- denotes ,
T14651 25672-25683 NNP denotes Biosciences
T14652 25684-25694 NNP denotes Pharmingen
T14653 25695-25696 -LRB- denotes (
T14654 25696-25699 NNP denotes San
T14655 25700-25705 NNP denotes Diego
T14656 25705-25706 -COMMA- denotes ,
T14657 25707-25709 NNP denotes CA
T14658 25709-25710 -COMMA- denotes ,
T14659 25711-25714 NNP denotes USA
T14660 25714-25715 -RRB- denotes )
T15102 25718-25722 NN denotes Cell
T15103 25723-25730 NN denotes sorting
T15104 25731-25737 RB denotes Highly
T15105 25738-25746 VB denotes purified
T15106 25747-25757 JJ denotes CD19+CD27-
T15107 25758-25760 CC denotes or
T15108 25761-25771 JJ denotes CD19+CD27+
T15109 25772-25777 NN denotes cells
T15110 25778-25782 VB denotes were
T15111 25783-25791 VB denotes obtained
T15112 25792-25794 IN denotes by
T15113 25795-25803 VB denotes staining
T15114 25804-25809 JJ denotes CD19+
T15115 25810-25815 NN denotes cells
T15116 25816-25820 IN denotes with
T15117 25821-25830 JJ denotes anti-CD27
T15118 25831-25833 NN denotes PE
T15119 25834-25837 CC denotes and
T15120 25838-25842 NN denotes CD19
T15121 25843-25846 NN denotes PC5
T15122 25847-25851 NN denotes mAbs
T15123 25852-25855 IN denotes for
T15124 25856-25858 CD denotes 30
T15125 25859-25866 NN denotes minutes
T15126 25867-25869 IN denotes at
T15127 25870-25873 NN denotes 4°C
T15128 25873-25874 -COMMA- denotes ,
T15129 25875-25883 VB denotes followed
T15130 25884-25886 IN denotes by
T15131 25887-25894 VB denotes washing
T15132 25895-25899 IN denotes with
T15133 25900-25903 NNP denotes PBS
T15134 25904-25907 CC denotes and
T15135 25908-25915 VB denotes sorting
T15136 25916-25918 IN denotes on
T15137 25919-25923 NNP denotes FACS
T15138 25924-25928 NNP denotes DiVa
T15139 25929-25933 IN denotes from
T15140 25934-25940 NNP denotes Becton
T15141 25941-25950 NNP denotes Dickinson
T15269 25953-25965 JJ denotes Western-blot
T15270 25966-25974 NN denotes analysis
T15271 25975-25976 NN denotes B
T15272 25977-25982 NN denotes cells
T15273 25983-25987 IN denotes from
T15274 25988-25998 JJ denotes peripheral
T15275 25999-26004 NN denotes blood
T15276 26005-26007 CC denotes or
T15277 26008-26016 VB denotes cultured
T15278 26017-26027 NN denotes cell-lines
T15279 26028-26032 VB denotes were
T15280 26033-26038 VB denotes lysed
T15281 26039-26041 IN denotes in
T15282 26042-26047 NN denotes lysis
T15283 26048-26054 NN denotes buffer
T15284 26055-26056 -LRB- denotes (
T15285 26056-26064 NN denotes glycerol
T15286 26065-26067 CD denotes 10
T15287 26067-26068 NN denotes %
T15288 26068-26069 -COMMA- denotes ,
T15289 26070-26087 NN denotes β-mercaptoethanol
T15290 26088-26089 CD denotes 5
T15291 26089-26090 NN denotes %
T15292 26090-26091 -COMMA- denotes ,
T15293 26092-26098 CD denotes 0.0625
T15294 26099-26100 NN denotes M
T15295 26101-26109 NN denotes Tris-HCL
T15296 26110-26111 -LRB- denotes [
T15297 26111-26113 NN denotes pH
T15298 26114-26117 CD denotes 6.8
T15299 26117-26118 -RRB- denotes ]
T15300 26118-26119 -COMMA- denotes ,
T15301 26120-26126 NN denotes sodium
T15302 26127-26134 NN denotes dodecyl
T15303 26135-26143 NN denotes sulphate
T15304 26144-26145 -LRB- denotes [
T15305 26145-26148 NN denotes SDS
T15306 26148-26149 -RRB- denotes ]
T15307 26150-26153 CD denotes 2.5
T15308 26153-26154 NN denotes %
T15309 26154-26159 NN denotes w/vol
T15310 26159-26160 -RRB- denotes )
T15311 26162-26167 JJ denotes Total
T15312 26168-26175 NN denotes protein
T15313 26176-26177 -LRB- denotes (
T15314 26177-26183 CD denotes 30–100
T15315 26184-26186 NN denotes μg
T15316 26186-26187 -RRB- denotes )
T15317 26188-26192 IN denotes from
T15318 26193-26197 DT denotes each
T15319 26198-26204 NN denotes sample
T15320 26205-26208 VB denotes was
T15321 26209-26212 VB denotes run
T15322 26213-26215 IN denotes on
T15323 26216-26218 CD denotes 10
T15324 26218-26219 NN denotes %
T15325 26220-26222 CC denotes or
T15326 26223-26225 CD denotes 12
T15327 26225-26226 NN denotes %
T15328 26227-26245 NN denotes SDS/polyacrylamide
T15329 26246-26247 -LRB- denotes (
T15330 26247-26255 NN denotes SDS/PAGE
T15331 26255-26256 -RRB- denotes )
T15332 26257-26261 NN denotes gels
T15333 26262-26265 CC denotes and
T15334 26266-26273 VB denotes blotted
T15335 26274-26278 IN denotes onto
T15336 26279-26293 NN denotes nitrocellulose
T15337 26294-26301 NN denotes filters
T15338 26302-26303 -LRB- denotes (
T15339 26303-26310 NNP denotes Protran
T15340 26310-26311 -COLON- denotes ;
T15341 26312-26322 NNP denotes Schleicher
T15342 26323-26324 CC denotes &
T15343 26324-26331 NNP denotes Schuell
T15344 26332-26336 NNP denotes GmbH
T15345 26336-26337 -COMMA- denotes ,
T15346 26338-26344 NNP denotes Dassel
T15347 26344-26345 -COMMA- denotes ,
T15348 26346-26353 NNP denotes Germany
T15349 26353-26354 -RRB- denotes )
T15350 26356-26364 NN denotes Blocking
T15351 26364-26365 -COMMA- denotes ,
T15352 26366-26373 NN denotes washing
T15353 26374-26377 CC denotes and
T15354 26378-26388 NN denotes incubation
T15355 26389-26391 IN denotes of
T15356 26392-26395 DT denotes the
T15357 26396-26403 NN denotes filters
T15358 26404-26408 IN denotes with
T15359 26409-26416 JJ denotes primary
T15360 26417-26427 NN denotes antibodies
T15361 26428-26432 VB denotes were
T15362 26433-26437 VB denotes done
T15363 26438-26447 VB denotes according
T15364 26448-26450 TO denotes to
T15365 26451-26454 DT denotes the
T15366 26455-26467 NN denotes manufacturer
T15367 26467-26469 POS denotes 's
T15368 26470-26479 NN denotes protocols
T15369 26480-26482 IN denotes at
T15370 26483-26487 NN denotes room
T15371 26488-26499 NN denotes temperature
T15372 26500-26501 -LRB- denotes (
T15373 26501-26503 NN denotes RT
T15374 26503-26504 -RRB- denotes )
T15375 26506-26511 IN denotes After
T15376 26512-26519 VB denotes washing
T15377 26520-26524 IN denotes with
T15378 26525-26532 NN denotes TBS/0.1
T15379 26532-26533 NN denotes %
T15380 26534-26542 CD denotes Tween-20
T15381 26543-26544 -LRB- denotes (
T15382 26544-26549 NN denotes TBS-T
T15383 26549-26550 -RRB- denotes )
T15384 26550-26551 -COMMA- denotes ,
T15385 26552-26555 DT denotes the
T15386 26556-26563 NN denotes filters
T15387 26564-26568 VB denotes were
T15388 26569-26578 VB denotes incubated
T15389 26579-26583 IN denotes with
T15390 26584-26595 NN denotes horseradish
T15391 26596-26606 NN denotes peroxidase
T15392 26607-26608 -LRB- denotes (
T15393 26608-26611 NN denotes HRP
T15394 26611-26612 -RRB- denotes )
T15395 26613-26620 VB denotes coupled
T15396 26621-26623 TO denotes to
T15397 26624-26632 JJ denotes relevant
T15398 26633-26642 JJ denotes secondary
T15399 26643-26653 NN denotes antibodies
T15400 26654-26655 -LRB- denotes (
T15401 26655-26658 VB denotes see
T15402 26659-26664 IN denotes above
T15403 26664-26665 -RRB- denotes )
T15404 26666-26669 IN denotes for
T15405 26670-26672 CD denotes 60
T15406 26673-26680 NN denotes minutes
T15407 26681-26683 IN denotes at
T15408 26684-26686 NN denotes RT
T15409 26688-26694 NN denotes Enzyme
T15410 26695-26703 NN denotes activity
T15411 26704-26707 VB denotes was
T15412 26708-26718 VB denotes visualised
T15413 26719-26721 IN denotes by
T15414 26722-26725 DT denotes the
T15415 26726-26734 VB denotes enhanced
T15416 26735-26752 NN denotes chemiluminescence
T15417 26753-26759 NN denotes system
T15418 26759-26760 -COMMA- denotes ,
T15419 26761-26769 NN denotes ECL+PLUS
T15420 26770-26771 -LRB- denotes (
T15421 26771-26779 NNP denotes Amersham
T15422 26779-26780 -COMMA- denotes ,
T15423 26781-26796 NNP denotes Buckinghamshire
T15424 26796-26797 -COMMA- denotes ,
T15425 26798-26800 NNP denotes UK
T15426 26800-26801 -RRB- denotes )
T15427 26803-26816 JJ denotes Densitometric
T15428 26817-26825 NN denotes analysis
T15429 26826-26829 VB denotes was
T15430 26830-26839 VB denotes performed
T15431 26840-26842 IN denotes by
T15432 26843-26851 VB denotes scanning
T15433 26852-26862 NN denotes hyperfilms
T15434 26863-26865 IN denotes on
T15435 26866-26867 DT denotes a
T15436 26868-26876 NNP denotes Personal
T15437 26877-26889 NNP denotes Densitometer
T15438 26890-26892 NNP denotes SI
T15439 26893-26894 -LRB- denotes (
T15440 26894-26903 NNP denotes Molecular
T15441 26904-26912 NNP denotes Dynamics
T15442 26912-26913 -COMMA- denotes ,
T15443 26914-26923 NNP denotes Sunnyvale
T15444 26923-26924 -COMMA- denotes ,
T15445 26925-26927 NNP denotes CA
T15446 26927-26928 -RRB- denotes )
T15447 26930-26944 NN denotes Quantification
T15448 26945-26947 IN denotes of
T15449 26948-26951 NN denotes Id1
T15450 26951-26952 -COMMA- denotes ,
T15451 26953-26956 NN denotes Id2
T15452 26957-26960 CC denotes and
T15453 26961-26964 NN denotes Id3
T15454 26965-26972 NN denotes protein
T15455 26973-26976 VB denotes was
T15456 26977-26987 VB denotes calculated
T15457 26988-26990 IN denotes by
T15458 26991-27002 VB denotes normalizing
T15459 27003-27006 DT denotes the
T15460 27007-27015 JJ denotes specific
T15461 27016-27023 NN denotes protein
T15462 27024-27029 NN denotes bands
T15463 27030-27032 TO denotes to
T15464 27033-27040 NN denotes β-actin
T15465 27041-27046 VB denotes using
T15466 27047-27052 NN denotes Image
T15467 27053-27058 JJ denotes Quant
T15468 27059-27062 CD denotes 5.5
T15469 27063-27071 NN denotes software
T15470 27072-27073 -LRB- denotes (
T15471 27073-27082 NNP denotes Molecular
T15472 27083-27091 NNP denotes Dynamics
T15473 27091-27092 -RRB- denotes )
T15608 27095-27103 NN denotes Analysis
T15609 27104-27106 IN denotes of
T15610 27107-27112 NN denotes BMP-6
T15611 27113-27122 NN denotes messenger
T15612 27123-27126 NN denotes RNA
T15613 27127-27128 -LRB- denotes (
T15614 27128-27132 NN denotes mRNA
T15615 27132-27133 -RRB- denotes )
T15616 27134-27144 NN denotes expression
T15617 27145-27155 JJ denotes Endogenous
T15618 27156-27166 NN denotes expression
T15619 27167-27169 IN denotes of
T15620 27170-27173 DT denotes the
T15621 27174-27179 NN denotes BMP-6
T15622 27180-27184 NN denotes gene
T15623 27185-27188 VB denotes was
T15624 27189-27197 VB denotes examined
T15625 27198-27200 IN denotes by
T15626 27201-27208 JJ denotes reverse
T15627 27209-27233 NN denotes transcription-polymerase
T15628 27234-27239 NN denotes chain
T15629 27240-27248 NN denotes reaction
T15630 27250-27255 JJ denotes Total
T15631 27256-27259 NN denotes RNA
T15632 27260-27263 VB denotes was
T15633 27264-27272 VB denotes isolated
T15634 27273-27278 VB denotes using
T15635 27279-27289 RB denotes Absolutely
T15636 27290-27294 NNP denotes RNA™
T15637 27295-27301 NN denotes RT-PCR
T15638 27302-27310 NNP denotes Miniprep
T15639 27311-27314 NN denotes Kit
T15640 27315-27316 -LRB- denotes (
T15641 27316-27326 NNP denotes Stratagene
T15642 27327-27333 NNP denotes Europe
T15643 27333-27334 -COMMA- denotes ,
T15644 27335-27344 NNP denotes Amsterdam
T15645 27344-27345 -COMMA- denotes ,
T15646 27346-27356 NNP denotes Netherland
T15647 27356-27357 -RRB- denotes )
T15648 27358-27367 VB denotes according
T15649 27368-27370 TO denotes to
T15650 27371-27374 DT denotes the
T15651 27375-27388 NN denotes manufacturers
T15652 27389-27401 NN denotes instructions
T15653 27403-27417 NN denotes Quantification
T15654 27418-27420 IN denotes of
T15655 27421-27424 DT denotes the
T15656 27425-27433 VB denotes isolated
T15657 27434-27439 JJ denotes total
T15658 27440-27443 NN denotes RNA
T15659 27444-27447 VB denotes was
T15660 27448-27456 VB denotes achieved
T15661 27457-27459 IN denotes by
T15662 27460-27465 VB denotes using
T15663 27466-27484 JJ denotes spectrophotometric
T15664 27485-27490 NN denotes OD260
T15665 27491-27503 NN denotes measurements
T15666 27505-27510 JJ denotes Equal
T15667 27511-27518 NN denotes amounts
T15668 27519-27521 IN denotes of
T15669 27522-27525 NN denotes RNA
T15670 27526-27530 VB denotes were
T15671 27531-27535 RB denotes then
T15672 27536-27543 VB denotes reverse
T15673 27544-27555 VB denotes transcribed
T15674 27556-27558 TO denotes to
T15675 27559-27563 NN denotes cDNA
T15676 27564-27568 IN denotes with
T15677 27569-27576 NNP denotes TaqMan®
T15678 27577-27584 NNP denotes Reverse
T15679 27585-27598 NN denotes Transcription
T15680 27599-27607 NN denotes Reagents
T15681 27608-27609 -LRB- denotes (
T15682 27609-27616 NNP denotes Applied
T15683 27617-27627 NNP denotes Biosystems
T15684 27627-27628 -COMMA- denotes ,
T15685 27629-27635 NNP denotes Foster
T15686 27636-27640 NNP denotes City
T15687 27640-27641 -COMMA- denotes ,
T15688 27642-27644 NNP denotes CA
T15689 27644-27645 -COMMA- denotes ,
T15690 27646-27651 NN denotes U.S.A
T15691 27651-27652 -RRB- denotes )
T15692 27654-27656 TO denotes To
T15693 27657-27664 VB denotes measure
T15694 27665-27669 NN denotes mRNA
T15695 27670-27680 NN denotes expression
T15696 27681-27683 IN denotes of
T15697 27684-27688 NN denotes BMP6
T15698 27688-27689 -COMMA- denotes ,
T15699 27690-27697 NN denotes Id1–Id4
T15700 27698-27701 CC denotes and
T15701 27702-27706 NN denotes PGK1
T15702 27707-27710 NN denotes PCR
T15703 27711-27715 VB denotes were
T15704 27716-27723 VB denotes carried
T15705 27724-27727 RP denotes out
T15706 27728-27732 IN denotes with
T15707 27733-27740 NNP denotes TaqMan®
T15708 27741-27750 JJ denotes universal
T15709 27751-27757 NN denotes master
T15710 27758-27761 NN denotes mix
T15711 27763-27770 NN denotes Primers
T15712 27771-27774 CC denotes and
T15713 27775-27781 NN denotes probes
T15714 27782-27786 VB denotes were
T15715 27787-27795 VB denotes provided
T15716 27796-27798 IN denotes by
T15717 27799-27814 NN denotes Assay-on-Demand
T15718 27815-27816 -LRB- denotes (
T15719 27816-27823 NNP denotes Applied
T15720 27824-27834 NNP denotes Biosystems
T15721 27834-27835 -RRB- denotes )
T15722 27837-27840 NN denotes PCR
T15723 27841-27850 NN denotes reactions
T15724 27851-27855 VB denotes were
T15725 27856-27863 VB denotes carried
T15726 27864-27867 RP denotes out
T15727 27868-27870 IN denotes in
T15728 27871-27872 DT denotes a
T15729 27873-27878 JJ denotes final
T15730 27879-27885 NN denotes volume
T15731 27886-27888 IN denotes of
T15732 27889-27891 CD denotes 25
T15733 27892-27894 NN denotes μl
T15734 27895-27896 -LRB- denotes (
T15735 27896-27901 NN denotes BMP-6
T15736 27901-27902 -RRB- denotes )
T15737 27903-27905 CC denotes or
T15738 27906-27908 CD denotes 20
T15739 27909-27911 NN denotes μl
T15740 27912-27913 -LRB- denotes (
T15741 27913-27916 NN denotes ID1
T15742 27916-27917 -RRB- denotes )
T15743 27919-27922 DT denotes The
T15744 27923-27927 NN denotes cDNA
T15745 27928-27933 VB denotes added
T15746 27934-27936 TO denotes to
T15747 27937-27941 DT denotes each
T15748 27942-27950 NN denotes reaction
T15749 27951-27954 VB denotes was
T15750 27955-27965 JJ denotes equivalent
T15751 27966-27968 TO denotes to
T15752 27969-27972 DT denotes the
T15753 27973-27978 NN denotes input
T15754 27979-27981 IN denotes of
T15755 27982-27984 CD denotes 20
T15756 27985-27987 NN denotes ng
T15757 27988-27990 IN denotes of
T15758 27991-27996 JJ denotes total
T15759 27997-28000 NN denotes RNA
T15760 28002-28005 DT denotes The
T15761 28006-28010 NN denotes gene
T15762 28011-28021 NN denotes expression
T15763 28022-28025 VB denotes was
T15764 28026-28036 VB denotes quantified
T15765 28037-28042 VB denotes using
T15766 28043-28046 DT denotes the
T15767 28047-28055 JJ denotes standard
T15768 28056-28061 NN denotes curve
T15769 28062-28068 NN denotes method
T15770 28069-28070 -LRB- denotes (
T15771 28070-28074 NN denotes BMP6
T15772 28074-28075 -RRB- denotes )
T15773 28075-28076 -COMMA- denotes ,
T15774 28077-28079 CC denotes or
T15775 28080-28083 DT denotes the
T15776 28084-28095 JJ denotes comparative
T15777 28096-28098 NN denotes CT
T15778 28099-28105 NN denotes method
T15779 28106-28107 -LRB- denotes (
T15780 28107-28110 NN denotes Id1
T15781 28110-28111 -RRB- denotes )
T15782 28112-28114 IN denotes as
T15783 28115-28124 VB denotes described
T15784 28125-28127 IN denotes in
T15785 28128-28135 NNP denotes ABI7700
T15786 28136-28140 NNP denotes User
T15787 28141-28149 NNP denotes Bulletin
T15788 28150-28151 CD denotes 2
T15789 28152-28153 -LRB- denotes (
T15790 28153-28160 NNP denotes Applied
T15791 28161-28171 NNP denotes Biosystems
T15792 28171-28172 -RRB- denotes )
T15793 28174-28177 DT denotes The
T15794 28178-28188 NN denotes expression
T15795 28189-28192 VB denotes was
T15796 28193-28197 RB denotes then
T15797 28198-28208 VB denotes normalized
T15798 28209-28211 TO denotes to
T15799 28212-28215 DT denotes the
T15800 28216-28226 NN denotes expression
T15801 28227-28232 NN denotes level
T15802 28233-28235 IN denotes of
T15803 28236-28240 NN denotes PGK1
T15804 28242-28246 NN denotes PGK1
T15805 28247-28250 VB denotes was
T15806 28251-28257 VB denotes chosen
T15807 28257-28258 -COMMA- denotes ,
T15808 28259-28266 IN denotes because
T15809 28267-28269 PRP denotes it
T15810 28270-28273 VB denotes has
T15811 28274-28278 VB denotes been
T15812 28279-28284 VB denotes shown
T15813 28285-28287 TO denotes to
T15814 28288-28292 VB denotes have
T15815 28293-28296 JJ denotes low
T15816 28297-28307 NN denotes expression
T15817 28308-28319 NN denotes variability
T15818 28320-28325 IN denotes among
T15819 28326-28336 NN denotes lymphocyte
T15820 28337-28346 NN denotes specimens
T15821 28347-28348 -LRB- denotes [
T15822 28348-28350 CD denotes 56
T15823 28350-28351 -RRB- denotes ]
T15824 28353-28363 NN denotes Expression
T15825 28364-28370 NN denotes levels
T15826 28371-28373 IN denotes in
T15827 28374-28375 NN denotes B
T15828 28376-28381 NN denotes cells
T15829 28382-28386 VB denotes were
T15830 28387-28391 RB denotes then
T15831 28392-28399 VB denotes related
T15832 28400-28402 TO denotes to
T15833 28403-28406 DT denotes the
T15834 28407-28417 NN denotes expression
T15835 28418-28424 NN denotes levels
T15836 28425-28427 IN denotes in
T15837 28428-28433 NN denotes Ramos
T15838 28434-28439 NN denotes cells
T16237 28442-28446 NN denotes Cell
T16238 28447-28460 NN denotes proliferation
T16239 28461-28464 IN denotes For
T16240 28465-28475 NN denotes estimation
T16241 28476-28478 IN denotes of
T16242 28479-28482 NN denotes DNA
T16243 28483-28492 NN denotes synthesis
T16244 28492-28493 -COMMA- denotes ,
T16245 28494-28499 JJ denotes CD19+
T16246 28500-28505 NN denotes cells
T16247 28506-28507 -LRB- denotes (
T16248 28507-28510 CD denotes 7.5
T16249 28511-28512 CC denotes ×
T16250 28513-28516 CD denotes 104
T16251 28517-28526 NN denotes cells/0.2
T16252 28527-28529 NN denotes ml
T16253 28529-28530 -RRB- denotes )
T16254 28531-28533 CC denotes or
T16255 28534-28539 NN denotes Ramos
T16256 28540-28545 NN denotes cells
T16257 28546-28547 -LRB- denotes (
T16258 28547-28548 CD denotes 1
T16259 28549-28550 NN denotes ×
T16260 28551-28554 CD denotes 104
T16261 28555-28564 NN denotes cells/0.2
T16262 28565-28567 NN denotes ml
T16263 28567-28568 -RRB- denotes )
T16264 28569-28573 VB denotes were
T16265 28574-28582 VB denotes cultured
T16266 28583-28585 IN denotes in
T16267 28586-28596 NN denotes triplicate
T16268 28597-28599 IN denotes in
T16269 28600-28610 NN denotes microtiter
T16270 28611-28616 NN denotes wells
T16271 28618-28621 DT denotes The
T16272 28622-28627 NN denotes cells
T16273 28628-28632 VB denotes were
T16274 28633-28639 VB denotes pulsed
T16275 28640-28644 IN denotes with
T16276 28645-28648 CD denotes 3.7
T16277 28649-28650 CC denotes ×
T16278 28651-28656 NN denotes 104Bq
T16279 28657-28658 -LRB- denotes [
T16280 28658-28660 NN denotes 3H
T16281 28660-28661 -RRB- denotes ]
T16282 28661-28670 NN denotes thymidine
T16283 28671-28672 -LRB- denotes (
T16284 28672-28680 NNP denotes Amersham
T16285 28680-28681 -COMMA- denotes ,
T16286 28682-28697 NNP denotes Buckinghamshire
T16287 28697-28698 -COMMA- denotes ,
T16288 28699-28701 NNP denotes UK
T16289 28701-28702 -RRB- denotes )
T16290 28703-28706 IN denotes for
T16291 28707-28710 DT denotes the
T16292 28711-28715 JJ denotes last
T16293 28716-28718 CD denotes 16
T16294 28719-28720 NN denotes h
T16295 28721-28723 IN denotes of
T16296 28724-28725 DT denotes a
T16297 28726-28730 JJ denotes 72-h
T16298 28731-28741 NN denotes incubation
T16299 28743-28746 DT denotes The
T16300 28747-28752 NN denotes cells
T16301 28753-28757 VB denotes were
T16302 28758-28767 VB denotes harvested
T16303 28768-28773 VB denotes using
T16304 28774-28776 DT denotes an
T16305 28777-28786 VB denotes automated
T16306 28787-28791 NN denotes cell
T16307 28792-28801 NN denotes harvester
T16308 28802-28803 -LRB- denotes (
T16309 28803-28810 NNP denotes Packard
T16310 28811-28821 NNP denotes Instrument
T16311 28822-28829 NNP denotes Company
T16312 28829-28830 -COMMA- denotes ,
T16313 28831-28838 NNP denotes Meriden
T16314 28838-28839 -COMMA- denotes ,
T16315 28840-28842 NNP denotes CT
T16316 28842-28843 -COMMA- denotes ,
T16317 28844-28847 NNP denotes USA
T16318 28847-28848 -RRB- denotes )
T16319 28849-28852 CC denotes and
T16320 28853-28854 -LRB- denotes [
T16321 28854-28856 NN denotes 3H
T16322 28856-28857 -RRB- denotes ]
T16323 28857-28866 NN denotes thymidine
T16324 28867-28880 NN denotes incorporation
T16325 28881-28884 VB denotes was
T16326 28885-28895 VB denotes determined
T16327 28896-28898 IN denotes in
T16328 28899-28900 DT denotes a
T16329 28901-28914 NN denotes scintillation
T16330 28915-28922 NN denotes counter
T16331 28923-28924 -LRB- denotes (
T16332 28924-28932 NNP denotes TopCount
T16333 28932-28933 -COMMA- denotes ,
T16334 28934-28941 NNP denotes Packard
T16335 28942-28952 NNP denotes Instrument
T16336 28953-28960 NNP denotes Company
T16337 28961-28965 NNP denotes Inc.
T16338 28965-28966 -COMMA- denotes ,
T16339 28967-28974 NNP denotes Meriden
T16340 28974-28975 -COMMA- denotes ,
T16341 28976-28978 NN denotes CT
T16342 28978-28979 -RRB- denotes )
T16481 28982-28995 NN denotes Determination
T16482 28996-28998 IN denotes of
T16483 28999-29003 NN denotes cell
T16484 29004-29009 NN denotes death
T16485 29010-29014 NN denotes Cell
T16486 29015-29020 NN denotes death
T16487 29021-29024 VB denotes was
T16488 29025-29033 VB denotes measured
T16489 29034-29036 IN denotes by
T16490 29037-29042 JJ denotes vital
T16491 29043-29046 NN denotes dye
T16492 29047-29056 NN denotes exclusion
T16493 29057-29061 NN denotes test
T16494 29062-29064 IN denotes by
T16495 29065-29073 VB denotes staining
T16496 29074-29079 NN denotes cells
T16497 29080-29084 IN denotes with
T16498 29085-29086 CD denotes 5
T16499 29087-29092 NN denotes μg/ml
T16500 29093-29102 NN denotes propidium
T16501 29103-29109 NN denotes iodide
T16502 29110-29111 -LRB- denotes (
T16503 29111-29112 -LRB- denotes [
T16504 29112-29114 NNP denotes PI
T16505 29114-29115 -RRB- denotes ]
T16506 29115-29116 -COLON- denotes ;
T16507 29117-29127 NNP denotes Calbiochem
T16508 29128-29133 NNP denotes Corp.
T16509 29133-29134 -COLON- denotes ;
T16510 29135-29137 NNP denotes La
T16511 29138-29143 NNP denotes Jolla
T16512 29143-29144 -COMMA- denotes ,
T16513 29145-29147 NNP denotes CA
T16514 29147-29148 -COLON- denotes ;
T16515 29149-29150 CD denotes 5
T16516 29151-29156 NN denotes mg/ml
T16517 29156-29157 -RRB- denotes )
T16518 29158-29161 IN denotes for
T16519 29162-29165 CD denotes one
T16520 29166-29172 NN denotes minute
T16521 29173-29175 IN denotes on
T16522 29176-29179 NN denotes ice
T16523 29181-29183 IN denotes At
T16524 29184-29189 JJ denotes least
T16525 29190-29195 CD denotes 1,000
T16526 29196-29201 NN denotes cells
T16527 29202-29205 IN denotes per
T16528 29206-29212 NN denotes sample
T16529 29213-29217 VB denotes were
T16530 29218-29221 VB denotes run
T16531 29222-29224 IN denotes on
T16532 29225-29226 DT denotes a
T16533 29227-29229 NN denotes BD
T16534 29230-29241 NN denotes FACSCalibur
T16535 29242-29246 NN denotes flow
T16536 29247-29256 NN denotes cytometer
T16609 29259-29270 JJ denotes Statistical
T16610 29271-29279 NN denotes analysis
T16611 29280-29283 DT denotes The
T16612 29284-29295 JJ denotes statistical
T16613 29296-29308 NN denotes significance
T16614 29309-29311 IN denotes of
T16615 29312-29323 NN denotes differences
T16616 29324-29331 IN denotes between
T16617 29332-29338 NN denotes groups
T16618 29339-29342 VB denotes was
T16619 29343-29353 VB denotes determined
T16620 29354-29359 VB denotes using
T16621 29360-29363 DT denotes the
T16622 29364-29370 JJ denotes paired
T16623 29371-29381 JJ denotes two-tailed
T16624 29382-29390 NNP denotes Wilcoxon
T16625 29391-29404 JJ denotes nonparametric
T16626 29405-29409 NN denotes test
T16627 29409-29410 -COMMA- denotes ,
T16628 29411-29413 IN denotes by
T16629 29414-29422 VB denotes applying
T16630 29423-29431 NN denotes SPSS10.1
T16631 29432-29440 NN denotes software
T16632 29441-29442 -LRB- denotes (
T16633 29442-29446 NNP denotes SPSS
T16634 29447-29451 NNP denotes Inc.
T16635 29451-29452 -COMMA- denotes ,
T16636 29453-29460 NNP denotes Chicago
T16637 29460-29461 -COMMA- denotes ,
T16638 29462-29464 NNP denotes IL
T16639 29464-29465 -COMMA- denotes ,
T16640 29466-29469 NNP denotes USA
T16641 29469-29470 -RRB- denotes )
T16642 29472-29473 NN denotes P
T16643 29474-29480 NN denotes values
T16644 29481-29485 JJ denotes less
T16645 29486-29490 IN denotes than
T16646 29491-29495 CD denotes 0.05
T16647 29496-29500 VB denotes were
T16648 29501-29511 VB denotes considered
T16649 29512-29523 JJ denotes significant
T1148 1414-1421 NN denotes Members
T1149 1422-1424 IN denotes of
T1150 1425-1428 DT denotes the
T1151 1429-1441 VB denotes transforming
T1152 1442-1448 NN denotes growth
T1153 1449-1455 NN denotes factor
T1154 1456-1457 NN denotes β
T1155 1458-1459 -LRB- denotes (
T1156 1459-1464 NN denotes TGF-β
T1157 1464-1465 -RRB- denotes )
T1158 1466-1477 NN denotes superfamily
T1159 1478-1482 VB denotes play
T1160 1483-1490 JJ denotes central
T1161 1491-1496 NN denotes roles
T1162 1497-1499 IN denotes in
T1163 1500-1511 VB denotes controlling
T1164 1512-1520 JJ denotes cellular
T1165 1521-1534 NN denotes proliferation
T1166 1534-1535 -COMMA- denotes ,
T1167 1536-1551 NN denotes differentiation
T1168 1551-1552 -COMMA- denotes ,
T1169 1553-1562 NN denotes migration
T1170 1563-1566 CC denotes and
T1171 1567-1576 NN denotes apoptosis
T1172 1577-1578 -LRB- denotes [
T1173 1578-1579 CD denotes 1
T1174 1579-1580 -RRB- denotes ]
T1175 1582-1587 DT denotes These
T1176 1588-1597 NN denotes cytokines
T1177 1598-1601 MD denotes can
T1178 1602-1604 VB denotes be
T1179 1605-1612 VB denotes divided
T1180 1613-1617 IN denotes into
T1181 1618-1623 CD denotes three
T1182 1624-1633 NN denotes subgroups
T1183 1633-1634 -COLON- denotes :
T1184 1635-1640 NN denotes TGF-β
T1185 1640-1641 -COMMA- denotes ,
T1186 1642-1645 DT denotes the
T1187 1646-1663 NN denotes activins/inhibins
T1188 1663-1664 -COMMA- denotes ,
T1189 1665-1668 CC denotes and
T1190 1669-1672 DT denotes the
T1191 1673-1677 NN denotes bone
T1192 1678-1691 JJ denotes morphogenetic
T6694 11368-11378 NN denotes antibodies
T9771 21960-21962 IN denotes of
R2101 T2653 T2654 arg1Of BMP-6,inhibits
R2102 T2656 T2655 arg1Of induced,anti-IgM
R2103 T2657 T2654 arg2Of proliferation,inhibits
R2104 T2657 T2656 arg1Of proliferation,induced
R2105 T2657 T2658 arg1Of proliferation,of
R2106 T2661 T2658 arg2Of cells,of
R2107 T2661 T2659 arg1Of cells,human
R2108 T2661 T2660 arg1Of cells,B
R2109 T2663 T2662 arg1Of effects,The
R2110 T2663 T2664 arg1Of effects,of
R2111 T2663 T2666 arg1Of effects,on
R2112 T2663 T2672 arg1Of effects,prompted
R2113 T2665 T2664 arg2Of BMP-6,of
R2114 T2667 T2668 arg1Of normal,and
R2115 T2669 T2668 arg2Of neoplastic,and
R2116 T2671 T2666 arg2Of cells,on
R2117 T2671 T2667 arg1Of cells,normal
R2118 T2671 T2669 arg1Of cells,neoplastic
R2119 T2671 T2670 arg1Of cells,hematopoietic
R2120 T2673 T2672 arg2Of us,prompted
R2121 T2673 T2675 arg1Of us,investigate
R2795 T3594 T3595 arg1Of BMP-6,induces
R2796 T3597 T3595 arg2Of death,induces
R2797 T3597 T3596 arg1Of death,cell
R2798 T3597 T3598 arg1Of death,in
R69 T191 T192 arg1Of BMP-6,inhibits
R70 T192 T199 arg1Of inhibits,;
R71 T193 T192 arg2Of growth,inhibits
R72 T193 T194 arg1Of growth,of
R73 T198 T194 arg2Of cells,of
R74 T198 T195 arg1Of cells,mature
R75 T198 T196 arg1Of cells,human
R76 T198 T197 arg1Of cells,B
R77 T200 T192 arg3Of induction,inhibits
R78 T200 T201 arg1Of induction,of
R79 T203 T202 arg1Of phosphorylation,Smad
R80 T203 T204 arg1Of phosphorylation,and
R81 T204 T201 arg2Of and,of
R82 T205 T204 arg2Of upregulation,and
R83 T205 T206 arg1Of upregulation,of
R84 T207 T206 arg2Of Id1,of
R85 T211 T209 arg1Of proteins,Bone
R86 T211 T210 arg1Of proteins,morphogenetic
R87 T211 T212 arg1Of proteins,(
R88 T211 T215 arg1Of proteins,belong
R89 T211 T221 arg1Of proteins,are
R90 T213 T212 arg2Of BMPs,(
R91 T214 T212 arg3Of ),(
R92 T215 T216 arg1Of belong,to
R93 T215 T220 arg1Of belong,and
R94 T219 T216 arg2Of superfamily,to
R95 T219 T217 arg1Of superfamily,the
R96 T219 T218 arg1Of superfamily,TGF-β
R97 T221 T220 arg2Of are,and
R98 T221 T227 arg1Of are,in
R99 T223 T221 arg2Of proteins,are
R100 T223 T222 arg2Of proteins,secreted
R101 T223 T224 arg1Of proteins,with
R102 T226 T224 arg2Of roles,with
R103 T226 T225 arg1Of roles,pleiotropic
R104 T231 T227 arg2Of types,in
R105 T231 T228 arg1Of types,many
R106 T231 T229 arg1Of types,different
R107 T231 T230 arg1Of types,cell
R108 T234 T232 arg1Of role,A
R109 T234 T233 arg1Of role,potential
R110 T234 T235 arg1Of role,of
R111 T234 T237 arg1Of role,in
R112 T234 T241 arg1Of role,has
R113 T234 T242 arg1Of role,been
R114 T234 T243 arg2Of role,implied
R115 T236 T235 arg2Of BMP-6,of
R116 T240 T237 arg2Of system,in
R117 T240 T238 arg1Of system,the
R118 T240 T239 arg1Of system,immune
R119 T243 T241 arg2Of implied,has
R120 T243 T242 arg2Of implied,been
R121 T246 T243 arg1Of studies,implied
R122 T246 T244 arg2Of studies,by
R123 T246 T245 arg1Of studies,various
R124 T246 T247 arg1Of studies,of
R125 T248 T249 arg1Of malignant,and
R126 T250 T249 arg2Of rheumatoid,and
R127 T251 T247 arg2Of diseases,of
R128 T251 T248 arg1Of diseases,malignant
R129 T251 T250 arg1Of diseases,rheumatoid
R130 T255 T252 arg2Of study,In
R131 T255 T253 arg1Of study,the
R132 T255 T254 arg1Of study,present
R133 T257 T258 arg1Of we,explored
R134 T258 T252 arg1Of explored,In
R135 T258 T256 arg1Of explored,","
R136 T260 T258 arg2Of role,explored
R137 T260 T259 arg1Of role,the
R138 T260 T261 arg1Of role,of
R139 T260 T263 arg1Of role,in
R140 T262 T261 arg2Of BMP-6,of
R141 T269 T263 arg2Of cells,in
R142 T269 T264 arg1Of cells,normal
R143 T269 T265 arg1Of cells,human
R144 T269 T266 arg1Of cells,peripheral
R145 T269 T267 arg1Of cells,blood
R146 T269 T268 arg1Of cells,B
R147 T273 T271 arg1Of cells,The
R148 T273 T272 arg1Of cells,B
R149 T273 T274 arg1Of cells,were
R150 T273 T275 arg2Of cells,found
R151 T273 T277 arg1Of cells,express
R152 T275 T274 arg2Of found,were
R153 T275 T285 arg1Of found,and
R154 T277 T275 arg3Of express,found
R155 T277 T276 arg1Of express,to
R156 T280 T281 arg1Of I,and
R157 T282 T281 arg2Of type,and
R158 T284 T277 arg2Of receptors,express
R159 T284 T278 arg1Of receptors,BMP
R160 T284 T279 arg1Of receptors,type
R161 T284 T280 arg1Of receptors,I
R162 T284 T282 arg1Of receptors,type
R163 T284 T283 arg1Of receptors,II
R164 T286 T288 arg1Of BMP-6,induced
R165 T288 T285 arg2Of induced,and
R166 T288 T287 arg1Of induced,rapidly
R167 T289 T288 arg2Of phosphorylation,induced
R168 T289 T290 arg1Of phosphorylation,of
R169 T291 T290 arg2Of Smad1/5/8,of
R170 T294 T295 arg1Of Smad-phosphorylation,was
R171 T294 T296 arg2Of Smad-phosphorylation,followed
R172 T296 T292 arg1Of followed,Furthermore
R173 T296 T293 arg1Of followed,","
R174 T296 T295 arg2Of followed,was
R175 T296 T305 arg1Of followed,","
R176 T296 T306 arg1Of followed,whereas
R177 T298 T296 arg1Of upregulation,followed
R178 T298 T297 arg2Of upregulation,by
R179 T298 T299 arg1Of upregulation,of
R180 T301 T300 arg1Of mRNA,Id1
R181 T301 T302 arg1Of mRNA,and
R182 T302 T299 arg2Of and,of
R183 T304 T302 arg2Of protein,and
R184 T304 T303 arg1Of protein,Id1
R185 T307 T308 arg1Of Id2,and
R186 T309 T308 arg2Of Id3,and
R187 T310 T307 arg1Of expression,Id2
R188 T310 T309 arg1Of expression,Id3
R189 T310 T311 arg1Of expression,was
R190 T310 T313 arg2Of expression,affected
R191 T313 T306 arg2Of affected,whereas
R192 T313 T311 arg2Of affected,was
R193 T313 T312 arg1Of affected,not
R194 T316 T317 arg1Of we,found
R195 T317 T314 arg1Of found,Furthermore
R196 T317 T315 arg1Of found,","
R197 T319 T320 arg1Of BMP-6,had
R198 T320 T317 arg2Of had,found
R199 T320 T318 arg1Of had,that
R200 T320 T325 arg1Of had,in
R201 T323 T320 arg2Of effect,had
R202 T323 T321 arg1Of effect,an
R203 T323 T322 arg1Of effect,antiproliferative
R204 T325 T324 arg1Of in,both
R205 T326 T327 arg1Of naïve,(
R206 T326 T330 arg1Of naïve,and
R207 T328 T327 arg2Of CD19+CD27-,(
R208 T329 T327 arg3Of ),(
R209 T332 T330 arg2Of B,and
R210 T332 T331 arg1Of B,memory
R211 T333 T325 arg2Of cells,in
R212 T333 T326 arg1Of cells,naïve
R213 T333 T332 arg1Of cells,B
R214 T333 T334 arg1Of cells,(
R215 T333 T337 arg2Of cells,stimulated
R216 T335 T334 arg2Of CD19+CD27+,(
R217 T336 T334 arg3Of ),(
R218 T337 T338 arg1Of stimulated,with
R219 T339 T340 arg1Of anti-IgM,alone
R220 T339 T341 arg1Of anti-IgM,or
R221 T341 T338 arg2Of or,with
R222 T344 T341 arg2Of action,or
R223 T344 T342 arg1Of action,the
R224 T344 T343 arg2Of action,combined
R225 T344 T345 arg1Of action,of
R226 T346 T347 arg1Of anti-IgM,and
R227 T347 T345 arg2Of and,of
R228 T348 T347 arg2Of CD40L,and
R229 T351 T352 arg1Of BMP-6,induced
R230 T352 T349 arg1Of induced,Additionally
R231 T352 T350 arg1Of induced,","
R232 T354 T352 arg2Of death,induced
R233 T354 T353 arg1Of death,cell
R234 T354 T355 arg1Of death,in
R235 T359 T355 arg2Of cells,in
R236 T359 T356 arg2Of cells,activated
R237 T359 T357 arg1Of cells,memory
R238 T359 T358 arg1Of cells,B
R239 T364 T362 arg1Of effect,the
R240 T364 T363 arg1Of effect,antiproliferative
R241 T364 T365 arg1Of effect,of
R242 T364 T367 arg1Of effect,in
R243 T364 T369 arg1Of effect,was
R244 T364 T371 arg2Of effect,neutralized
R245 T366 T365 arg2Of BMP-6,of
R246 T368 T367 arg2Of B-cells,in
R247 T371 T360 arg1Of neutralized,Importantly
R248 T371 T361 arg1Of neutralized,","
R249 T371 T369 arg2Of neutralized,was
R250 T371 T370 arg1Of neutralized,completely
R251 T375 T371 arg1Of antagonist,neutralized
R252 T375 T372 arg2Of antagonist,by
R253 T375 T373 arg1Of antagonist,the
R254 T375 T374 arg1Of antagonist,natural
R255 T375 T376 arg1Of antagonist,","
R256 T377 T376 arg2Of noggin,","
R257 T381 T380 arg1Of cells,B
R258 T381 T382 arg1Of cells,were
R259 T381 T383 arg2Of cells,demonstrated
R260 T381 T385 arg1Of cells,upregulate
R261 T383 T378 arg1Of demonstrated,Furthermore
R262 T383 T379 arg1Of demonstrated,","
R263 T383 T382 arg2Of demonstrated,were
R264 T385 T383 arg3Of upregulate,demonstrated
R265 T385 T384 arg1Of upregulate,to
R266 T385 T388 arg1Of upregulate,upon
R267 T387 T385 arg2Of mRNA,upregulate
R268 T387 T386 arg1Of mRNA,BMP-6
R269 T389 T388 arg2Of stimulation,upon
R270 T389 T390 arg1Of stimulation,with
R271 T391 T390 arg2Of anti-IgM,with
R272 T397 T393 arg2Of cells,In
R273 T397 T394 arg1Of cells,mature
R274 T397 T395 arg1Of cells,human
R275 T397 T396 arg1Of cells,B
R276 T399 T400 arg1Of BMP-6,inhibited
R277 T399 T406 arg1Of BMP-6,induced
R278 T400 T404 arg1Of inhibited,and
R279 T402 T400 arg2Of growth,inhibited
R280 T402 T401 arg1Of growth,cell
R281 T404 T393 arg1Of and,In
R282 T404 T398 arg1Of and,","
R283 T404 T403 arg1Of and,","
R284 T406 T404 arg2Of induced,and
R285 T406 T405 arg1Of induced,rapidly
R286 T407 T406 arg2Of phosphorylation,induced
R287 T407 T408 arg1Of phosphorylation,of
R288 T409 T408 arg2Of Smad1/5/8,of
R289 T409 T410 arg2Of Smad1/5/8,followed
R290 T413 T410 arg1Of upregulation,followed
R291 T413 T411 arg2Of upregulation,by
R292 T413 T412 arg1Of upregulation,an
R293 T413 T414 arg1Of upregulation,of
R294 T415 T414 arg2Of Id1,of
R859 T1158 T1151 arg1Of superfamily,transforming
R860 T1158 T1154 arg1Of superfamily,β
R861 T1159 T1162 arg1Of play,in
R862 T1161 T1159 arg2Of roles,play
R863 T1161 T1160 arg1Of roles,central
R864 T1163 T1162 arg2Of controlling,in
R865 T1165 T1164 arg1Of proliferation,cellular
R866 T1165 T1166 arg1Of proliferation,","
R867 T1166 T1168 arg1Of ",",","
R868 T1167 T1166 arg2Of differentiation,","
R869 T1168 T1170 arg1Of ",",and
R870 T1169 T1168 arg2Of migration,","
R871 T1170 T1163 arg2Of and,controlling
R872 T1171 T1170 arg2Of apoptosis,and
R873 T1171 T1172 arg1Of apoptosis,[
R874 T1173 T1172 arg2Of 1,[
R875 T1174 T1172 arg3Of ],[
R876 T1176 T1175 arg1Of cytokines,These
R877 T1176 T1177 arg1Of cytokines,can
R878 T1176 T1178 arg1Of cytokines,be
R879 T1176 T1179 arg2Of cytokines,divided
R880 T1179 T1177 arg2Of divided,can
R881 T1179 T1178 arg2Of divided,be
R882 T1179 T1180 arg1Of divided,into
R883 T1182 T1180 arg2Of subgroups,into
R884 T1182 T1181 arg1Of subgroups,three
R885 T1182 T1183 arg1Of subgroups,:
R886 T1184 T1185 arg1Of TGF-β,","
R887 T1184 T1189 arg1Of TGF-β,and
R888 T1187 T1185 arg2Of activins/inhibins,","
R889 T1187 T1186 arg1Of activins/inhibins,the
R890 T1189 T1183 arg2Of and,:
R891 T1189 T1188 arg1Of and,","
R892 T1193 T1189 arg2Of proteins,and
R893 T1193 T1190 arg1Of proteins,the
R894 T1193 T1191 arg1Of proteins,bone
R895 T1193 T1192 arg1Of proteins,morphogenetic
R896 T1193 T1194 arg1Of proteins,(
R897 T1193 T1197 arg1Of proteins,","
R898 T1193 T1198 arg2Of proteins,of
R899 T1193 T1199 arg1Of proteins,which
R900 T1195 T1194 arg2Of BMPs,(
R901 T1196 T1194 arg3Of ),(
R902 T1201 T1200 arg1Of latter,the
R903 T1201 T1202 arg1Of latter,constitute
R904 T1202 T1198 arg1Of constitute,of
R905 T1205 T1202 arg2Of family,constitute
R906 T1205 T1203 arg1Of family,the
R907 T1205 T1204 arg1Of family,largest
R908 T1206 T1207 arg1Of BMPs,are
R909 T1208 T1209 arg1Of 30–38,kDa
R910 T1208 T1210 arg1Of 30–38,hetero-
R911 T1208 T1211 arg1Of 30–38,or
R912 T1212 T1211 arg2Of homodimeric,or
R913 T1213 T1207 arg2Of proteins,are
R914 T1213 T1208 arg1Of proteins,30–38
R915 T1213 T1212 arg1Of proteins,homodimeric
R916 T1213 T1215 arg2Of proteins,identified
R917 T1215 T1214 arg1Of identified,originally
R918 T1218 T1215 arg1Of ability,identified
R919 T1218 T1216 arg2Of ability,by
R920 T1218 T1217 arg1Of ability,their
R921 T1218 T1219 modOf ability,to
R922 T1220 T1219 arg1Of induce,to
R923 T1220 T1226 arg1Of induce,[
R924 T1222 T1221 arg1Of cartilage,ectopic
R925 T1222 T1223 arg1Of cartilage,and
R926 T1223 T1220 arg2Of and,induce
R927 T1225 T1223 arg2Of formation,and
R928 T1225 T1224 arg1Of formation,bone
R929 T1227 T1226 arg2Of "2,3",[
R930 T1228 T1226 arg3Of ],[
R931 T1230 T1229 arg1Of studies,Several
R932 T1230 T1231 arg1Of studies,have
R933 T1230 T1232 arg1Of studies,demonstrated
R934 T1232 T1231 arg2Of demonstrated,have
R935 T1232 T1244 arg1Of demonstrated,recently
R936 T1232 T1245 arg1Of demonstrated,","
R937 T1232 T1247 arg1Of demonstrated,in
R938 T1235 T1232 arg2Of role,demonstrated
R939 T1235 T1233 arg1Of role,an
R940 T1235 T1234 arg1Of role,essential
R941 T1235 T1236 arg1Of role,of
R942 T1235 T1239 arg1Of role,during
R943 T1235 T1242 arg1Of role,and
R944 T1238 T1236 arg2Of proteins,of
R945 T1238 T1237 arg1Of proteins,these
R946 T1240 T1239 arg2Of embryogenesis,during
R947 T1242 T1241 arg1Of and,","
R948 T1244 T1243 arg1Of recently,more
R949 T1247 T1246 arg1Of in,also
R950 T1249 T1247 arg2Of tissues,in
R951 T1249 T1248 arg1Of tissues,adult
R952 T1249 T1250 arg1Of tissues,[
R953 T1251 T1250 arg2Of 1,[
R954 T1252 T1250 arg3Of ],[
R955 T1253 T1254 arg1Of TGF-β,has
R956 T1253 T1255 arg1Of TGF-β,been
R957 T1253 T1257 arg2Of TGF-β,studied
R958 T1253 T1265 arg1Of TGF-β,is
R959 T1257 T1254 arg2Of studied,has
R960 T1257 T1255 arg2Of studied,been
R961 T1257 T1256 arg1Of studied,intensively
R962 T1257 T1258 arg1Of studied,in
R963 T1257 T1264 arg1Of studied,and
R964 T1259 T1260 arg1Of normal,and
R965 T1261 T1260 arg2Of malignant,and
R966 T1263 T1258 arg2Of cells,in
R967 T1263 T1259 arg1Of cells,normal
R968 T1263 T1261 arg1Of cells,malignant
R969 T1263 T1262 arg1Of cells,haematopoietic
R970 T1265 T1264 arg2Of is,and
R971 T1266 T1265 arg2Of one,is
R972 T1266 T1267 arg1Of one,of
R973 T1271 T1269 arg1Of endogenous,most
R974 T1271 T1270 arg1Of endogenous,potent
R975 T1273 T1267 arg2Of regulators,of
R976 T1273 T1268 arg1Of regulators,the
R977 T1273 T1271 arg1Of regulators,endogenous
R978 T1273 T1272 arg1Of regulators,negative
R979 T1273 T1274 arg2Of regulators,known
R980 T1274 T1275 arg1Of known,to
R981 T1276 T1275 arg2Of date.,to
R982 T1276 T1277 arg1Of date.,[
R983 T1278 T1277 arg2Of 4,[
R984 T1279 T1277 arg3Of ],[
R985 T1281 T1280 arg2Of contrast,In
R986 T1284 T1283 arg1Of effect,the
R987 T1284 T1285 arg1Of effect,of
R988 T1284 T1287 arg1Of effect,in
R989 T1284 T1291 arg1Of effect,has
R990 T1284 T1293 arg1Of effect,been
R991 T1284 T1295 arg2Of effect,investigated
R992 T1286 T1285 arg2Of BMPs,of
R993 T1290 T1287 arg2Of system,in
R994 T1290 T1288 arg1Of system,the
R995 T1290 T1289 arg1Of system,immune
R996 T1295 T1280 arg1Of investigated,In
R997 T1295 T1282 arg1Of investigated,","
R998 T1295 T1291 arg2Of investigated,has
R999 T1295 T1292 arg1Of investigated,not
R1000 T1295 T1293 arg2Of investigated,been
R1001 T1295 T1294 arg1Of investigated,widely
R1002 T1298 T1296 arg2Of respect,In
R1003 T1298 T1297 arg1Of respect,that
R1004 T1300 T1301 arg1Of BMP-,2
R1005 T1300 T1302 arg1Of BMP-,","
R1006 T1302 T1304 arg1Of ",",and
R1007 T1303 T1302 arg2Of -4,","
R1008 T1304 T1306 arg1Of and,have
R1009 T1304 T1307 arg1Of and,been
R1010 T1304 T1308 arg2Of and,found
R1011 T1304 T1310 arg1Of and,control
R1012 T1305 T1304 arg2Of -7,and
R1013 T1308 T1296 arg1Of found,In
R1014 T1308 T1299 arg1Of found,","
R1015 T1308 T1306 arg2Of found,have
R1016 T1308 T1307 arg2Of found,been
R1017 T1310 T1308 arg3Of control,found
R1018 T1310 T1309 arg1Of control,to
R1019 T1311 T1312 arg1Of differentiation,of
R1020 T1311 T1319 arg1Of differentiation,and
R1021 T1315 T1312 arg2Of cells,of
R1022 T1315 T1313 arg1Of cells,hematopoietic
R1023 T1315 T1314 arg1Of cells,stem
R1024 T1315 T1316 arg1Of cells,[
R1025 T1317 T1316 arg2Of 5,[
R1026 T1318 T1316 arg3Of ],[
R1027 T1319 T1310 arg2Of and,control
R1028 T1323 T1319 arg2Of development,and
R1029 T1323 T1320 arg1Of development,early
R1030 T1323 T1321 arg1Of development,T
R1031 T1323 T1322 arg1Of development,cell
R1032 T1323 T1324 arg1Of development,[
R1033 T1325 T1324 arg2Of "6,7",[
R1034 T1326 T1324 arg3Of ],[
R1035 T1327 T1328 arg1Of BMP-6,has
R1036 T1327 T1329 arg1Of BMP-6,been
R1037 T1327 T1330 arg2Of BMP-6,reported
R1038 T1327 T1332 arg1Of BMP-6,reduce
R1039 T1330 T1328 arg2Of reported,has
R1040 T1330 T1329 arg2Of reported,been
R1041 T1332 T1330 arg3Of reduce,reported
R1042 T1332 T1331 arg1Of reduce,to
R1043 T1334 T1332 arg2Of number,reduce
R1044 T1334 T1333 arg1Of number,the
R1045 T1334 T1335 arg1Of number,of
R1046 T1337 T1335 arg2Of cells,of
R1047 T1337 T1336 arg1Of cells,cobblestone-area-forming
R1048 T1337 T1338 arg1Of cells,of
R1049 T1342 T1338 arg2Of cells,of
R1050 T1342 T1339 arg1Of cells,normal
R1051 T1342 T1340 arg1Of cells,human
R1052 T1342 T1341 arg1Of cells,haematopoietic
R1053 T1342 T1343 arg1Of cells,[
R1054 T1344 T1343 arg2Of 8,[
R1055 T1345 T1343 arg3Of ],[
R1056 T1348 T1349 arg1Of BMP-2,","
R1057 T1349 T1351 arg1Of ",",","
R1058 T1350 T1349 arg2Of -4,","
R1059 T1351 T1353 arg1Of ",",and
R1060 T1352 T1351 arg2Of 6,","
R1061 T1353 T1355 arg1Of and,had
R1062 T1354 T1353 arg2Of -7,and
R1063 T1355 T1346 arg1Of had,Furthermore
R1064 T1355 T1347 arg1Of had,","
R1065 T1355 T1362 arg1Of had,on
R1066 T1357 T1358 arg1Of antiproliferative,and
R1067 T1360 T1358 arg2Of proapoptotic,and
R1068 T1360 T1359 arg1Of proapoptotic,a
R1069 T1361 T1355 arg2Of effect,had
R1070 T1361 T1356 arg1Of effect,an
R1071 T1361 T1357 arg1Of effect,antiproliferative
R1072 T1361 T1360 arg1Of effect,proapoptotic
R1073 T1365 T1362 arg2Of cells,on
R1074 T1365 T1363 arg1Of cells,multiple
R1075 T1365 T1364 arg1Of cells,myeloma
R1076 T1365 T1366 arg1Of cells,[
R1077 T1367 T1366 arg2Of 9-11,[
R1078 T1368 T1366 arg3Of ],[
R1079 T1370 T1369 arg2Of addition,In
R1080 T1375 T1372 arg2Of profiling,by
R1081 T1375 T1373 arg1Of profiling,gene
R1082 T1375 T1374 arg1Of profiling,expression
R1083 T1377 T1379 arg1Of BMP-6,increased
R1084 T1377 T1389 arg1Of BMP-6,was
R1085 T1377 T1390 arg2Of BMP-6,associated
R1086 T1379 T1388 arg1Of increased,and
R1087 T1382 T1379 arg2Of value,increased
R1088 T1382 T1380 arg1Of value,the
R1089 T1382 T1381 arg1Of value,predictive
R1090 T1382 T1383 arg1Of value,for
R1091 T1387 T1383 arg2Of test,for
R1092 T1387 T1384 arg1Of test,a
R1093 T1387 T1385 arg1Of test,multi-gene
R1094 T1387 T1386 arg1Of test,signature
R1095 T1388 T1369 arg1Of and,In
R1096 T1388 T1371 arg1Of and,","
R1097 T1388 T1372 arg1Of and,by
R1098 T1388 T1376 arg1Of and,","
R1099 T1388 T1378 arg1Of and,significantly
R1100 T1390 T1388 arg2Of associated,and
R1101 T1390 T1389 arg2Of associated,was
R1102 T1390 T1391 arg1Of associated,with
R1103 T1390 T1404 arg1Of associated,[
R1104 T1394 T1391 arg2Of outcome,with
R1105 T1394 T1392 arg1Of outcome,a
R1106 T1394 T1393 arg1Of outcome,poor
R1107 T1394 T1395 arg1Of outcome,in
R1108 T1400 T1395 arg2Of lymphomas,in
R1109 T1400 T1396 arg1Of lymphomas,diffuse
R1110 T1400 T1397 arg1Of lymphomas,large
R1111 T1400 T1398 arg1Of lymphomas,B
R1112 T1400 T1399 arg1Of lymphomas,cell
R1113 T1400 T1401 arg1Of lymphomas,(
R1114 T1402 T1401 arg2Of DLBCL,(
R1115 T1403 T1401 arg3Of ),(
R1116 T1405 T1404 arg2Of 12,[
R1117 T1406 T1404 arg3Of ],[
R1118 T1407 T1408 arg1Of BMP-6,","
R1119 T1407 T1409 arg1Of BMP-6,like
R1120 T1407 T1414 arg1Of BMP-6,","
R1121 T1413 T1409 arg2Of members,like
R1122 T1413 T1410 arg1Of members,the
R1123 T1413 T1411 arg1Of members,other
R1124 T1413 T1412 arg1Of members,BMP
R1125 T1414 T1416 arg1Of ",",through
R1126 T1414 T1424 arg1Of ",",[
R1127 T1414 T1430 arg1Of ",",and
R1128 T1415 T1414 arg2Of signals,","
R1129 T1417 T1418 arg1Of ligation,and
R1130 T1418 T1416 arg2Of and,through
R1131 T1418 T1420 arg1Of and,of
R1132 T1419 T1418 arg2Of heterodimerzation,and
R1133 T1422 T1420 arg2Of type,of
R1134 T1422 T1421 arg1Of type,BMP
R1135 T1422 T1423 arg1Of type,I
R1136 T1425 T1424 arg2Of activin-like-kinase,[
R1137 T1425 T1426 arg1Of activin-like-kinase,(
R1138 T1427 T1426 arg2Of ALK,(
R1139 T1428 T1426 arg3Of ),(
R1140 T1429 T1424 arg3Of ],[
R1141 T1430 T1436 arg1Of and,","
R1142 T1430 T1437 arg1Of and,which
R1143 T1430 T1439 arg1Of and,propagates
R1144 T1435 T1430 arg2Of receptors,and
R1145 T1435 T1431 arg1Of receptors,type
R1146 T1435 T1432 arg1Of receptors,II
R1147 T1435 T1433 arg1Of receptors,serine-threonine
R1148 T1435 T1434 arg1Of receptors,kinase
R1149 T1439 T1438 arg1Of propagates,subsequently
R1150 T1439 T1442 arg1Of propagates,downstream
R1151 T1439 T1443 arg1Of propagates,by
R1152 T1441 T1439 arg2Of signal,propagates
R1153 T1441 T1440 arg1Of signal,the
R1154 T1444 T1443 arg2Of phosphorylating,by
R1155 T1446 T1444 arg2Of proteins,phosphorylating
R1156 T1446 T1445 arg1Of proteins,Smad
R1157 T1447 T1448 arg1Of BMP-6,can
R1158 T1447 T1449 arg1Of BMP-6,signal
R1159 T1449 T1448 arg2Of signal,can
R1160 T1449 T1450 arg1Of signal,through
R1161 T1452 T1450 arg2Of ligation,through
R1162 T1452 T1451 arg1Of ligation,the
R1163 T1452 T1453 arg1Of ligation,of
R1164 T1452 T1474 arg1Of ligation,","
R1165 T1452 T1475 arg1Of ligation,which
R1166 T1452 T1476 arg1Of ligation,lead
R1167 T1457 T1455 arg1Of receptors,type
R1168 T1457 T1456 arg1Of receptors,I
R1169 T1458 T1459 arg1Of Act-RIA,","
R1170 T1459 T1457 arg1Of ",",receptors
R1171 T1459 T1462 arg1Of ",",and
R1172 T1460 T1459 arg2Of BMP-RIA,","
R1173 T1462 T1454 arg1Of and,the
R1174 T1462 T1461 arg1Of and,","
R1175 T1462 T1464 arg1Of and,and
R1176 T1463 T1462 arg2Of BMP-RIB,and
R1177 T1464 T1453 arg2Of and,of
R1178 T1468 T1466 arg1Of receptors,type
R1179 T1468 T1467 arg1Of receptors,II
R1180 T1469 T1470 arg1Of BMP-RII,","
R1181 T1470 T1472 arg1Of ",",and
R1182 T1471 T1470 arg2Of Act-RIIA,","
R1183 T1472 T1464 arg2Of and,and
R1184 T1472 T1465 arg1Of and,the
R1185 T1472 T1468 arg1Of and,receptors
R1186 T1473 T1472 arg2Of Act-RIIB,and
R1187 T1476 T1477 arg1Of lead,to
R1188 T1479 T1477 arg2Of phosphorylation,to
R1189 T1479 T1478 arg1Of phosphorylation,the
R1190 T1479 T1480 arg1Of phosphorylation,of
R1191 T1483 T1480 arg2Of Smads,of
R1192 T1483 T1481 arg1Of Smads,the
R1193 T1483 T1482 arg1Of Smads,receptor
R1194 T1483 T1484 arg1Of Smads,(
R1195 T1485 T1486 arg1Of Smad-1,","
R1196 T1486 T1489 arg1Of ",",and
R1197 T1487 T1486 arg2Of Smad-5,","
R1198 T1489 T1484 arg2Of and,(
R1199 T1489 T1488 arg1Of and,","
R1200 T1490 T1489 arg2Of Smad-8,and
R1201 T1491 T1484 arg3Of ),(
R1202 T1494 T1492 arg1Of Smads,The
R1203 T1494 T1493 arg1Of Smads,R-
R1204 T1494 T1496 arg1Of Smads,form
R1205 T1494 T1505 arg1Of Smads,are
R1206 T1494 T1506 arg2Of Smads,translocated
R1207 T1496 T1498 arg1Of form,with
R1208 T1496 T1504 arg1Of form,and
R1209 T1497 T1496 arg2Of complexes,form
R1210 T1500 T1498 arg2Of co-Smad,with
R1211 T1500 T1499 arg1Of co-Smad,the
R1212 T1500 T1501 arg1Of co-Smad,(
R1213 T1502 T1501 arg2Of Smad4,(
R1214 T1503 T1501 arg3Of ),(
R1215 T1504 T1495 arg1Of and,then
R1216 T1506 T1504 arg2Of translocated,and
R1217 T1506 T1505 arg2Of translocated,are
R1218 T1506 T1507 arg1Of translocated,into
R1219 T1509 T1507 arg2Of nucleus,into
R1220 T1509 T1508 arg1Of nucleus,the
R1221 T1509 T1510 arg1Of nucleus,where
R1222 T1511 T1512 arg1Of they,exert
R1223 T1512 T1510 arg2Of exert,where
R1224 T1512 T1515 arg1Of exert,[
R1225 T1514 T1512 arg2Of regulation,exert
R1226 T1514 T1513 arg1Of regulation,gene
R1227 T1516 T1515 arg2Of "1,13",[
R1228 T1517 T1515 arg3Of ],[
R1229 T1521 T1518 arg2Of role,Given
R1230 T1521 T1519 arg1Of role,the
R1231 T1521 T1520 arg2Of role,reported
R1232 T1521 T1522 arg1Of role,of
R1233 T1521 T1524 arg1Of role,in
R1234 T1523 T1522 arg2Of BMP-6,of
R1235 T1526 T1525 arg1Of malignancies,B-cell
R1236 T1526 T1527 arg1Of malignancies,and
R1237 T1527 T1524 arg2Of and,in
R1238 T1530 T1527 arg2Of cells,and
R1239 T1530 T1528 arg1Of cells,haematopoietic
R1240 T1530 T1529 arg1Of cells,progenitor
R1241 T1532 T1533 arg1Of we,wanted
R1242 T1532 T1535 arg1Of we,explore
R1243 T1533 T1518 arg1Of wanted,Given
R1244 T1533 T1531 arg1Of wanted,","
R1245 T1535 T1533 arg2Of explore,wanted
R1246 T1535 T1534 arg1Of explore,to
R1247 T1535 T1539 arg1Of explore,in
R1248 T1538 T1535 arg2Of role,explore
R1249 T1538 T1536 arg1Of role,its
R1250 T1538 T1537 arg1Of role,potential
R1251 T1543 T1539 arg2Of cells,in
R1252 T1543 T1540 arg1Of cells,normal
R1253 T1543 T1541 arg1Of cells,human
R1254 T1543 T1542 arg1Of cells,B
R1255 T1544 T1545 arg1Of We,studied
R1256 T1547 T1545 arg2Of effects,studied
R1257 T1547 T1546 arg1Of effects,the
R1258 T1547 T1548 arg1Of effects,of
R1259 T1547 T1550 arg1Of effects,on
R1260 T1549 T1548 arg2Of BMP-6,of
R1261 T1551 T1552 arg1Of proliferation,and
R1262 T1552 T1550 arg2Of and,on
R1263 T1552 T1554 arg1Of and,on
R1264 T1553 T1552 arg2Of apoptosis,and
R1265 T1559 T1554 arg2Of cells,on
R1266 T1559 T1555 arg1Of cells,resting
R1267 T1559 T1556 arg1Of cells,and
R1268 T1559 T1557 arg2Of cells,stimulated
R1269 T1559 T1558 arg1Of cells,B
R1270 T1563 T1562 arg1Of expression,the
R1271 T1563 T1564 arg1Of expression,of
R1272 T1563 T1569 arg1Of expression,induced
R1273 T1563 T1585 arg1Of expression,were
R1274 T1563 T1586 arg2Of expression,resolved
R1275 T1566 T1565 arg1Of receptors,BMP
R1276 T1566 T1567 arg1Of receptors,and
R1277 T1567 T1564 arg2Of and,of
R1278 T1568 T1567 arg2Of BMP-6,and
R1279 T1569 T1576 arg1Of induced,with
R1280 T1569 T1584 arg1Of induced,","
R1281 T1570 T1569 arg2Of activation,induced
R1282 T1570 T1571 arg1Of activation,of
R1283 T1575 T1571 arg2Of pathway,of
R1284 T1575 T1572 arg1Of pathway,the
R1285 T1575 T1573 arg1Of pathway,Smad
R1286 T1575 T1574 arg1Of pathway,signalling
R1287 T1578 T1576 arg2Of regulation,with
R1288 T1578 T1577 arg1Of regulation,subsequent
R1289 T1578 T1579 arg1Of regulation,of
R1290 T1583 T1579 arg2Of Id1–Id4,of
R1291 T1583 T1580 arg1Of Id1–Id4,the
R1292 T1583 T1581 arg1Of Id1–Id4,target
R1293 T1583 T1582 arg1Of Id1–Id4,genes
R1294 T1584 T1560 arg1Of ",",Furthermore
R1295 T1584 T1561 arg1Of ",",","
R1296 T1586 T1584 arg2Of resolved,","
R1297 T1586 T1585 arg2Of resolved,were
R1298 T1589 T1590 arg1Of we,investigated
R1299 T1590 T1587 arg1Of investigated,Finally
R1300 T1590 T1588 arg1Of investigated,","
R1301 T1593 T1592 arg1Of cells,B
R1302 T1593 T1595 arg1Of cells,were
R1303 T1593 T1596 arg1Of cells,capable
R1304 T1593 T1598 arg1Of cells,producing
R1305 T1595 T1590 arg2Of were,investigated
R1306 T1595 T1591 arg1Of were,whether
R1307 T1595 T1594 arg1Of were,also
R1308 T1596 T1595 arg2Of capable,were
R1309 T1596 T1597 arg1Of capable,of
R1310 T1598 T1597 arg2Of producing,of
R1311 T1599 T1598 arg2Of BMP-6,producing
R2122 T2675 T2672 arg3Of investigate,prompted
R2123 T2675 T2674 arg1Of investigate,to
R2124 T2677 T2675 arg2Of effects,investigate
R2125 T2677 T2676 arg1Of effects,the
R2126 T2677 T2678 arg1Of effects,of
R2127 T2677 T2680 arg1Of effects,on
R2128 T2679 T2678 arg2Of BMP-6,of
R2129 T2684 T2680 arg2Of cells,on
R2130 T2684 T2681 arg1Of cells,normal
R2131 T2684 T2682 arg1Of cells,human
R2132 T2684 T2683 arg1Of cells,B
R2133 T2686 T2685 arg1Of experiments,All
R2134 T2686 T2687 arg1Of experiments,in
R2135 T2686 T2690 arg1Of experiments,were
R2136 T2686 T2691 arg2Of experiments,performed
R2137 T2689 T2687 arg2Of study,in
R2138 T2689 T2688 arg1Of study,this
R2139 T2691 T2690 arg2Of performed,were
R2140 T2691 T2692 arg1Of performed,under
R2141 T2691 T2695 arg1Of performed,as
R2142 T2694 T2692 arg2Of conditions,under
R2143 T2694 T2693 arg1Of conditions,serum-free
R2144 T2696 T2697 arg1Of FCS,has
R2145 T2696 T2698 arg1Of FCS,been
R2146 T2696 T2699 arg2Of FCS,shown
R2147 T2696 T2701 arg1Of FCS,interfere
R2148 T2699 T2695 arg2Of shown,as
R2149 T2699 T2697 arg2Of shown,has
R2150 T2699 T2698 arg2Of shown,been
R2151 T2701 T2699 arg3Of interfere,shown
R2152 T2701 T2700 arg1Of interfere,to
R2153 T2701 T2702 arg1Of interfere,with
R2154 T2703 T2702 arg2Of BMP-signalling,with
R2155 T2703 T2704 arg1Of BMP-signalling,[
R2156 T2703 T2707 arg1Of BMP-signalling,(
R2157 T2705 T2704 arg2Of 14,[
R2158 T2706 T2704 arg3Of ],[
R2159 T2709 T2707 arg2Of observations,(
R2160 T2709 T2708 arg1Of observations,own
R2161 T2710 T2707 arg3Of ),(
R2162 T2712 T2711 arg1Of study,To
R2163 T2714 T2712 arg2Of effect,study
R2164 T2714 T2713 arg1Of effect,the
R2165 T2714 T2715 arg1Of effect,of
R2166 T2714 T2717 arg1Of effect,on
R2167 T2716 T2715 arg2Of BMP-6,of
R2168 T2718 T2717 arg2Of proliferation,on
R2169 T2720 T2721 arg1Of B-cells,from
R2170 T2720 T2724 arg1Of B-cells,were
R2171 T2720 T2725 arg2Of B-cells,stimulated
R2172 T2723 T2721 arg2Of volunteers,from
R2173 T2723 T2722 arg1Of volunteers,healthy
R2174 T2725 T2711 modOf stimulated,To
R2175 T2725 T2719 arg1Of stimulated,","
R2176 T2725 T2724 arg2Of stimulated,were
R2177 T2725 T2726 arg1Of stimulated,with
R2178 T2727 T2728 arg1Of anti-IgM,and/or
R2179 T2728 T2726 arg2Of and/or,with
R2180 T2728 T2730 arg1Of and/or,in
R2181 T2729 T2728 arg2Of CD40L,and/or
R2182 T2732 T2733 arg1Of presence,or
R2183 T2733 T2730 arg2Of or,in
R2184 T2733 T2731 arg1Of or,the
R2185 T2733 T2735 arg1Of or,of
R2186 T2733 T2737 arg1Of or,for
R2187 T2734 T2733 arg2Of absence,or
R2188 T2736 T2735 arg2Of BMP-6,of
R2189 T2739 T2737 arg2Of days,for
R2190 T2739 T2738 arg1Of days,three
R2191 T2740 T2741 arg1Of We,found
R2192 T2743 T2744 arg1Of BMP-6,led
R2193 T2744 T2741 arg2Of led,found
R2194 T2744 T2742 arg1Of led,that
R2195 T2744 T2745 arg1Of led,to
R2196 T2747 T2748 arg1Of 35,%
R2197 T2750 T2745 arg2Of reduction,to
R2198 T2750 T2746 arg1Of reduction,a
R2199 T2750 T2747 arg1Of reduction,35
R2200 T2750 T2749 arg1Of reduction,mean
R2201 T2750 T2751 arg1Of reduction,of
R2202 T2755 T2751 arg2Of synthesis,of
R2203 T2755 T2752 arg1Of synthesis,anti-IgM-
R2204 T2755 T2753 arg2Of synthesis,induced
R2205 T2755 T2754 arg1Of synthesis,DNA
R2206 T2755 T2756 arg1Of synthesis,(
R2207 T2757 T2756 arg2Of n,(
R2208 T2757 T2758 arg1Of n,=
R2209 T2758 T2759 arg1Of =,8
R2210 T2758 T2760 arg1Of =,;
R2211 T2761 T2760 arg2Of p,;
R2212 T2761 T2762 arg1Of p,≤
R2213 T2761 T2764 arg1Of p,","
R2214 T2763 T2762 arg2Of 0.0002,≤
R2215 T2766 T2764 arg2Of 1A,","
R2216 T2766 T2765 arg1Of 1A,Figure
R2217 T2767 T2756 arg3Of ),(
R2218 T2769 T2768 arg1Of results,Similar
R2219 T2769 T2770 arg1Of results,were
R2220 T2769 T2771 arg2Of results,obtained
R2221 T2771 T2770 arg2Of obtained,were
R2222 T2771 T2772 arg1Of obtained,for
R2223 T2774 T2772 arg2Of cells,for
R2224 T2774 T2773 arg1Of cells,B
R2225 T2774 T2775 arg2Of cells,treated
R2226 T2775 T2776 arg1Of treated,with
R2227 T2777 T2778 arg1Of anti-IgM,and
R2228 T2778 T2776 arg2Of and,with
R2229 T2778 T2780 arg1Of and,(
R2230 T2779 T2778 arg2Of CD40L,and
R2231 T2782 T2781 arg1Of %,26
R2232 T2783 T2782 arg1Of mean,%
R2233 T2784 T2780 arg2Of reduction,(
R2234 T2784 T2783 arg1Of reduction,mean
R2235 T2784 T2785 arg1Of reduction,","
R2236 T2784 T2789 arg1Of reduction,;
R2237 T2786 T2785 arg2Of n,","
R2238 T2786 T2787 arg1Of n,=
R2239 T2787 T2788 arg1Of =,6
R2240 T2790 T2791 arg1Of p,≤
R2241 T2791 T2789 arg2Of ≤,;
R2242 T2792 T2791 arg2Of 0.023,≤
R2243 T2793 T2780 arg3Of ),(
R2244 T2796 T2794 arg1Of inhibition,The
R2245 T2796 T2795 arg1Of inhibition,BMP-6-induced
R2246 T2796 T2797 arg1Of inhibition,of
R2247 T2796 T2799 arg1Of inhibition,was
R2248 T2796 T2800 arg1Of inhibition,dose-dependent
R2249 T2798 T2797 arg2Of proliferation,of
R2250 T2800 T2799 arg2Of dose-dependent,was
R2251 T2800 T2801 arg1Of dose-dependent,in
R2252 T2805 T2802 arg1Of cells,both
R2253 T2805 T2803 arg1Of cells,peripheral
R2254 T2805 T2804 arg1Of cells,B
R2255 T2805 T2806 arg1Of cells,(
R2256 T2805 T2810 arg1Of cells,and
R2257 T2808 T2806 arg2Of 1B,(
R2258 T2808 T2807 arg1Of 1B,Figure
R2259 T2809 T2806 arg3Of ),(
R2260 T2810 T2801 arg2Of and,in
R2261 T2816 T2810 arg2Of Ramos,and
R2262 T2816 T2811 arg1Of Ramos,the
R2263 T2816 T2812 arg1Of Ramos,Burkitt
R2264 T2816 T2813 arg1Of Ramos,lymphoma
R2265 T2816 T2814 arg1Of Ramos,cell
R2266 T2816 T2815 arg1Of Ramos,line
R2267 T2816 T2817 arg1Of Ramos,(
R2268 T2818 T2819 arg1Of 40,%
R2269 T2820 T2817 arg2Of reduction,(
R2270 T2820 T2818 arg1Of reduction,40
R2271 T2820 T2821 arg1Of reduction,of
R2272 T2820 T2824 arg1Of reduction,","
R2273 T2823 T2821 arg2Of synthesis,of
R2274 T2823 T2822 arg1Of synthesis,DNA
R2275 T2826 T2824 arg2Of 1C,","
R2276 T2826 T2825 arg1Of 1C,Figure
R2277 T2827 T2817 arg3Of ),(
R2278 T2830 T2828 arg1Of effects,The
R2279 T2830 T2829 arg1Of effects,BMP-6
R2280 T2830 T2831 arg1Of effects,could
R2281 T2830 T2832 arg1Of effects,be
R2282 T2830 T2833 arg2Of effects,reversed
R2283 T2833 T2831 arg2Of reversed,could
R2284 T2833 T2832 arg2Of reversed,be
R2285 T2835 T2833 arg1Of addition,reversed
R2286 T2835 T2834 arg2Of addition,by
R2287 T2835 T2836 arg1Of addition,of
R2288 T2840 T2836 arg2Of Noggin,of
R2289 T2840 T2837 arg1Of Noggin,the
R2290 T2840 T2838 arg1Of Noggin,extracellular
R2291 T2840 T2839 arg1Of Noggin,inhibitor
R2292 T2840 T2841 arg1Of Noggin,(
R2293 T2843 T2841 arg2Of 1D,(
R2294 T2843 T2842 arg1Of 1D,Figure
R2295 T2844 T2841 arg3Of ),(
R2296 T2848 T2847 arg1Of combination,a
R2297 T2848 T2849 arg1Of combination,of
R2298 T2848 T2858 arg1Of combination,neutralized
R2299 T2854 T2855 arg1Of BMP-RIB-Fc,and
R2300 T2855 T2849 arg2Of and,of
R2301 T2855 T2850 arg1Of and,the
R2302 T2855 T2851 arg1Of and,soluble
R2303 T2855 T2852 arg1Of and,BMP
R2304 T2855 T2853 arg1Of and,receptors
R2305 T2856 T2855 arg2Of BMP-RII-Fc,and
R2306 T2858 T2845 arg1Of neutralized,Similarly
R2307 T2858 T2846 arg1Of neutralized,","
R2308 T2858 T2857 arg1Of neutralized,also
R2309 T2860 T2858 arg2Of effects,neutralized
R2310 T2860 T2859 arg1Of effects,the
R2311 T2860 T2861 arg1Of effects,of
R2312 T2860 T2863 arg1Of effects,(
R2313 T2862 T2861 arg2Of BMP-6,of
R2314 T2864 T2863 arg2Of data,(
R2315 T2864 T2866 arg2Of data,shown
R2316 T2866 T2865 arg1Of shown,not
R2317 T2867 T2863 arg3Of ),(
R2318 T2870 T2871 arg1Of we,wanted
R2319 T2870 T2873 arg1Of we,test
R2320 T2871 T2868 arg1Of wanted,Next
R2321 T2871 T2869 arg1Of wanted,","
R2322 T2873 T2871 arg2Of test,wanted
R2323 T2873 T2872 arg1Of test,to
R2324 T2875 T2876 arg1Of BMP-6,had
R2325 T2876 T2873 arg2Of had,test
R2326 T2876 T2874 arg1Of had,whether
R2327 T2878 T2876 arg2Of effect,had
R2328 T2878 T2877 arg1Of effect,different
R2329 T2878 T2879 arg1Of effect,on
R2330 T2880 T2881 arg1Of naïve,and
R2331 T2882 T2881 arg2Of memory,and
R2332 T2884 T2879 arg2Of cells,on
R2333 T2884 T2880 arg1Of cells,naïve
R2334 T2884 T2882 arg1Of cells,memory
R2335 T2884 T2883 arg1Of cells,B
R2336 T2885 T2886 arg1Of Naïve,(
R2337 T2885 T2889 arg1Of Naïve,and
R2338 T2887 T2886 arg2Of CD19+CD27-,(
R2339 T2888 T2886 arg3Of ),(
R2340 T2890 T2889 arg2Of memory,and
R2341 T2890 T2896 modOf memory,were
R2342 T2892 T2891 arg2Of CD19+CD27+,(
R2343 T2893 T2891 arg3Of ),(
R2344 T2895 T2891 arg1Of cells,(
R2345 T2895 T2894 arg1Of cells,B
R2346 T2895 T2896 arg1Of cells,were
R2347 T2895 T2897 arg2Of cells,isolated
R2348 T2895 T2914 arg2Of cells,tested
R2349 T2897 T2898 arg1Of isolated,from
R2350 T2897 T2913 arg1Of isolated,and
R2351 T2900 T2898 arg2Of blood,from
R2352 T2900 T2899 arg1Of blood,peripheral
R2353 T2900 T2901 arg1Of blood,by
R2354 T2903 T2901 arg2Of sorting,by
R2355 T2903 T2902 arg1Of sorting,cell
R2356 T2903 T2904 arg1Of sorting,of
R2357 T2908 T2904 arg2Of cells,of
R2358 T2908 T2905 arg1Of cells,immunobead-isolated
R2359 T2908 T2906 arg1Of cells,CD19+
R2360 T2908 T2907 arg1Of cells,B
R2361 T2908 T2909 arg1Of cells,[
R2362 T2910 T2909 arg2Of 15,[
R2363 T2911 T2909 arg3Of ],[
R2364 T2913 T2896 arg2Of and,were
R2365 T2913 T2912 arg1Of and,","
R2366 T2914 T2913 arg2Of tested,and
R2367 T2914 T2915 arg1Of tested,for
R2368 T2917 T2915 arg2Of capacity,for
R2369 T2917 T2916 arg1Of capacity,their
R2370 T2917 T2918 modOf capacity,to
R2371 T2919 T2918 arg1Of proliferate,to
R2372 T2919 T2920 arg1Of proliferate,in
R2373 T2922 T2920 arg2Of presence,in
R2374 T2922 T2921 arg1Of presence,the
R2375 T2922 T2923 arg1Of presence,of
R2376 T2924 T2923 arg2Of BMP-6,of
R2377 T2927 T2928 arg1Of BMP-6,inhibited
R2378 T2928 T2925 arg1Of inhibited,However
R2379 T2928 T2926 arg1Of inhibited,","
R2380 T2928 T2933 arg1Of inhibited,in
R2381 T2928 T2937 arg1Of inhibited,to
R2382 T2928 T2941 arg1Of inhibited,","
R2383 T2928 T2942 arg1Of inhibited,with
R2384 T2930 T2929 arg1Of induced,anti-IgM
R2385 T2932 T2928 arg2Of synthesis,inhibited
R2386 T2932 T2930 arg1Of synthesis,induced
R2387 T2932 T2931 arg1Of synthesis,DNA
R2388 T2936 T2933 arg2Of subpopulations,in
R2389 T2936 T2934 arg1Of subpopulations,the
R2390 T2936 T2935 arg1Of subpopulations,two
R2391 T2940 T2937 arg2Of extent,to
R2392 T2940 T2938 arg1Of extent,a
R2393 T2940 T2939 arg1Of extent,similar
R2394 T2945 T2942 arg2Of reduction,with
R2395 T2945 T2943 arg1Of reduction,a
R2396 T2945 T2944 arg1Of reduction,mean
R2397 T2945 T2946 arg1Of reduction,of
R2398 T2945 T2948 arg1Of reduction,of
R2399 T2945 T2951 arg1Of reduction,(
R2400 T2945 T2960 arg1Of reduction,for
R2401 T2947 T2946 arg2Of DNA-synthesis,of
R2402 T2950 T2948 arg2Of %,of
R2403 T2950 T2949 arg1Of %,45
R2404 T2952 T2951 arg2Of n,(
R2405 T2952 T2953 arg1Of n,=
R2406 T2952 T2955 arg1Of n,;
R2407 T2953 T2954 arg1Of =,5
R2408 T2956 T2957 arg1Of p,≤
R2409 T2957 T2955 arg2Of ≤,;
R2410 T2958 T2957 arg2Of "0,004",≤
R2411 T2959 T2951 arg3Of ),(
R2412 T2963 T2961 arg1Of cells,naïve
R2413 T2963 T2962 arg1Of cells,B
R2414 T2963 T2964 arg1Of cells,and
R2415 T2964 T2960 arg2Of and,for
R2416 T2966 T2964 arg2Of %,and
R2417 T2966 T2965 arg1Of %,48
R2418 T2966 T2967 arg1Of %,(
R2419 T2966 T2976 arg1Of %,for
R2420 T2968 T2967 arg2Of n,(
R2421 T2968 T2969 arg1Of n,=
R2422 T2968 T2971 arg1Of n,;
R2423 T2969 T2970 arg1Of =,5
R2424 T2972 T2973 arg1Of p,≤
R2425 T2973 T2971 arg2Of ≤,;
R2426 T2974 T2973 arg2Of "0,001",≤
R2427 T2975 T2967 arg3Of ),(
R2428 T2979 T2976 arg2Of cells,for
R2429 T2979 T2977 arg1Of cells,memory
R2430 T2979 T2978 arg1Of cells,B
R2431 T2979 T2980 arg1Of cells,(
R2432 T2982 T2980 arg2Of 1E,(
R2433 T2982 T2981 arg1Of 1E,Figure
R2434 T2983 T2980 arg3Of ),(
R2799 T3602 T3599 arg1Of cells,human
R2800 T3602 T3600 arg1Of cells,memory
R2801 T3602 T3601 arg1Of cells,B
R2802 T3602 T3603 arg1Of cells,and
R2803 T3603 T3598 arg2Of and,in
R2804 T3605 T3603 arg2Of cells,and
R2805 T3605 T3604 arg1Of cells,Ramos
R2806 T3608 T3609 arg1Of we,wanted
R2807 T3608 T3611 arg1Of we,establish
R2808 T3609 T3606 arg1Of wanted,Next
R2809 T3609 T3607 arg1Of wanted,","
R2810 T3611 T3609 arg2Of establish,wanted
R2811 T3611 T3610 arg1Of establish,to
R2812 T3613 T3615 arg1Of BMP-6,could
R2813 T3613 T3616 arg1Of BMP-6,affect
R2814 T3616 T3611 arg2Of affect,establish
R2815 T3616 T3612 arg1Of affect,whether
R2816 T3616 T3614 arg1Of affect,also
R2817 T3616 T3615 arg2Of affect,could
R2818 T3618 T3616 arg2Of viability,affect
R2819 T3618 T3617 arg1Of viability,the
R2820 T3618 T3619 arg1Of viability,of
R2821 T3622 T3619 arg2Of cells,of
R2822 T3622 T3620 arg1Of cells,normal
R2823 T3622 T3621 arg1Of cells,B
R2824 T3624 T3623 arg1Of viability,Cell
R2825 T3624 T3625 arg1Of viability,was
R2826 T3624 T3626 arg2Of viability,determined
R2827 T3626 T3625 arg2Of determined,was
R2828 T3626 T3634 arg1Of determined,after
R2829 T3629 T3628 arg1Of iodide,propidium
R2830 T3629 T3630 arg1Of iodide,(
R2831 T3631 T3630 arg2Of PI,(
R2832 T3632 T3630 arg3Of ),(
R2833 T3633 T3626 arg1Of staining,determined
R2834 T3633 T3627 arg2Of staining,by
R2835 T3633 T3629 arg1Of staining,iodide
R2836 T3635 T3634 arg2Of culture,after
R2837 T3635 T3636 arg1Of culture,with
R2838 T3635 T3638 arg1Of culture,without
R2839 T3636 T3637 arg1Of with,or
R2840 T3638 T3637 arg2Of without,or
R2841 T3639 T3636 arg2Of BMP-6,with
R2842 T3639 T3638 arg2Of BMP-6,without
R2843 T3639 T3640 arg1Of BMP-6,for
R2844 T3642 T3640 arg2Of hours,for
R2845 T3642 T3641 arg1Of hours,48
R2846 T3645 T3646 arg1Of BMP-6,showed
R2847 T3646 T3643 arg1Of showed,Interestingly
R2848 T3646 T3644 arg1Of showed,","
R2849 T3646 T3657 arg1Of showed,from
R2850 T3648 T3650 arg1Of small,but
R2851 T3650 T3649 arg1Of but,","
R2852 T3651 T3650 arg2Of reproducible,but
R2853 T3653 T3646 arg2Of increase,showed
R2854 T3653 T3647 arg1Of increase,a
R2855 T3653 T3648 arg1Of increase,small
R2856 T3653 T3651 arg1Of increase,reproducible
R2857 T3653 T3652 arg1Of increase,mean
R2858 T3653 T3654 arg1Of increase,of
R2859 T3656 T3654 arg2Of death,of
R2860 T3656 T3655 arg1Of death,cell
R2861 T3657 T3671 arg1Of from,in
R2862 T3658 T3659 arg1Of 17,to
R2863 T3660 T3659 arg2Of 23,to
R2864 T3661 T3657 arg2Of %,from
R2865 T3661 T3658 arg1Of %,17
R2866 T3661 T3662 arg1Of %,(
R2867 T3663 T3662 arg2Of n,(
R2868 T3663 T3664 arg1Of n,=
R2869 T3663 T3666 arg1Of n,;
R2870 T3664 T3665 arg1Of =,5
R2871 T3667 T3668 arg1Of p,≤
R2872 T3668 T3666 arg2Of ≤,;
R2873 T3669 T3668 arg2Of "0,003",≤
R2874 T3670 T3662 arg3Of ),(
R2875 T3677 T3671 arg2Of cells,in
R2876 T3677 T3672 arg1Of cells,anti-IgM
R2877 T3677 T3673 arg2Of cells,stimulated
R2878 T3677 T3674 arg1Of cells,CD27+
R2879 T3677 T3675 arg1Of cells,memory
R2880 T3677 T3676 arg1Of cells,B
R2881 T3681 T3680 arg1Of cells,Ramos
R2882 T3681 T3682 arg1Of cells,showed
R2883 T3682 T3678 arg1Of showed,Furthermore
R2884 T3682 T3679 arg1Of showed,","
R2885 T3682 T3689 arg1Of showed,from
R2886 T3685 T3682 arg2Of increase,showed
R2887 T3685 T3683 arg1Of increase,a
R2888 T3685 T3684 arg1Of increase,mean
R2889 T3685 T3686 arg1Of increase,in
R2890 T3688 T3686 arg2Of death,in
R2891 T3688 T3687 arg1Of death,cell
R2892 T3690 T3691 arg1Of 20,to
R2893 T3692 T3691 arg2Of 50,to
R2894 T3693 T3689 arg2Of %,from
R2895 T3693 T3690 arg1Of %,20
R2896 T3693 T3694 arg1Of %,(
R2897 T3693 T3706 arg1Of %,after
R2898 T3695 T3694 arg2Of n,(
R2899 T3695 T3696 arg1Of n,=
R2900 T3695 T3698 arg1Of n,","
R2901 T3695 T3702 arg1Of n,","
R2902 T3696 T3697 arg1Of =,3
R2903 T3699 T3698 arg2Of p,","
R2904 T3699 T3700 arg1Of p,<
R2905 T3700 T3701 arg1Of <,"0,001"
R2906 T3703 T3702 arg2Of figure,","
R2907 T3703 T3704 arg1Of figure,3
R2908 T3705 T3694 arg3Of ),(
R2909 T3708 T3706 arg2Of treatment,after
R2910 T3708 T3707 arg1Of treatment,BMP-6
R2911 T3710 T3709 arg2Of contrast,In
R2912 T3713 T3712 arg1Of death,cell
R2913 T3713 T3714 arg1Of death,of
R2914 T3713 T3718 arg1Of death,(
R2915 T3713 T3731 arg1Of death,or
R2916 T3717 T3714 arg2Of cells,of
R2917 T3717 T3715 arg1Of cells,total
R2918 T3717 T3716 arg1Of cells,CD19+
R2919 T3719 T3720 arg1Of n,=
R2920 T3719 T3722 arg1Of n,;
R2921 T3719 T3724 arg1Of n,≤
R2922 T3720 T3721 arg1Of =,6
R2923 T3723 T3722 arg2Of p,;
R2924 T3724 T3718 arg2Of ≤,(
R2925 T3725 T3724 arg2Of "0,32",≤
R2926 T3725 T3726 arg1Of "0,32",;
R2927 T3727 T3726 arg2Of data,;
R2928 T3727 T3729 arg2Of data,shown
R2929 T3729 T3728 arg1Of shown,not
R2930 T3730 T3718 arg3Of ),(
R2931 T3731 T3736 arg1Of or,was
R2932 T3731 T3739 arg2Of or,affected
R2933 T3735 T3731 arg2Of cells,or
R2934 T3735 T3732 arg1Of cells,CD27-IgG-
R2935 T3735 T3733 arg1Of cells,naïve
R2936 T3735 T3734 arg1Of cells,B
R2937 T3739 T3709 arg1Of affected,In
R2938 T3739 T3711 arg1Of affected,","
R2939 T3739 T3736 arg2Of affected,was
R2940 T3739 T3737 arg1Of affected,not
R2941 T3739 T3738 arg1Of affected,significantly
R2942 T3739 T3740 arg1Of affected,(
R2943 T3741 T3740 arg2Of n,(
R2944 T3741 T3742 arg1Of n,=
R2945 T3742 T3743 arg1Of =,5
R2946 T3742 T3744 arg1Of =,;
R2947 T3745 T3744 arg2Of p,;
R2948 T3745 T3746 arg1Of p,≤
R2949 T3745 T3748 arg1Of p,","
R2950 T3747 T3746 arg2Of "0,65",≤
R2951 T3749 T3748 arg2Of figure,","
R2952 T3749 T3750 arg1Of figure,2
R2953 T3751 T3740 arg3Of ),(
R3151 T4061 T4059 arg1Of cells,Human
R3152 T4061 T4060 arg1Of cells,B
R3153 T4061 T4062 arg1Of cells,express
R3154 T4064 T4062 arg2Of receptors,express
R3155 T4064 T4063 arg1Of receptors,BMP-6
R3156 T4066 T4065 arg1Of knowledge,Detailed
R3157 T4066 T4067 arg1Of knowledge,regarding
R3158 T4066 T4076 arg1Of knowledge,is
R3159 T4066 T4079 arg1Of knowledge,available
R3160 T4068 T4067 arg2Of expression,regarding
R3161 T4068 T4069 arg1Of expression,of
R3162 T4068 T4073 arg1Of expression,in
R3163 T4072 T4069 arg2Of receptors,of
R3164 T4072 T4070 arg1Of receptors,different
R3165 T4072 T4071 arg1Of receptors,BMP
R3166 T4075 T4073 arg2Of cells,in
R3167 T4075 T4074 arg1Of cells,B
R3168 T4076 T4077 arg1Of is,currently
R3169 T4076 T4078 arg1Of is,not
R3170 T4079 T4076 arg2Of available,is
R3171 T4082 T4080 arg1Of elucidate,To
R3172 T4082 T4081 arg1Of elucidate,further
R3173 T4084 T4082 arg2Of role,elucidate
R3174 T4084 T4083 arg1Of role,the
R3175 T4084 T4085 arg1Of role,of
R3176 T4084 T4087 arg1Of role,in
R3177 T4086 T4085 arg2Of BMPs,of
R3178 T4090 T4087 arg2Of cells,in
R3179 T4090 T4088 arg1Of cells,human
R3180 T4090 T4089 arg1Of cells,B
R3181 T4092 T4082 arg1Of we,elucidate
R3182 T4092 T4093 arg1Of we,performed
R3183 T4093 T4080 modOf performed,To
R3184 T4093 T4091 arg1Of performed,","
R3185 T4096 T4093 arg2Of analysis,performed
R3186 T4096 T4094 arg1Of analysis,western
R3187 T4096 T4095 arg1Of analysis,blot
R3188 T4096 T4097 arg1Of analysis,for
R3189 T4099 T4100 arg1Of I,and
R3190 T4101 T4100 arg2Of type,and
R3191 T4104 T4097 arg2Of receptors,for
R3192 T4104 T4098 arg1Of receptors,type
R3193 T4104 T4099 arg1Of receptors,I
R3194 T4104 T4101 arg1Of receptors,type
R3195 T4104 T4102 arg1Of receptors,II
R3196 T4104 T4103 arg1Of receptors,BMP
R3197 T4106 T4105 arg1Of analysis,This
R3198 T4106 T4107 arg1Of analysis,revealed
R3199 T4112 T4109 arg1Of receptors,the
R3200 T4112 T4110 arg1Of receptors,type
R3201 T4112 T4111 arg1Of receptors,I
R3202 T4112 T4113 arg1Of receptors,Act-RIA
R3203 T4112 T4115 arg1Of receptors,BMP-RIB
R3204 T4112 T4116 arg1Of receptors,and
R3205 T4113 T4114 arg1Of Act-RIA,","
R3206 T4115 T4114 arg2Of BMP-RIB,","
R3207 T4116 T4124 arg1Of and,are
R3208 T4116 T4125 arg2Of and,expressed
R3209 T4120 T4118 arg1Of receptors,type
R3210 T4120 T4119 arg1Of receptors,II
R3211 T4121 T4122 arg1Of BMP-RII,and
R3212 T4122 T4116 arg2Of and,and
R3213 T4122 T4117 arg1Of and,the
R3214 T4122 T4120 arg1Of and,receptors
R3215 T4123 T4122 arg2Of Act-RIIb,and
R3216 T4125 T4107 arg2Of expressed,revealed
R3217 T4125 T4108 arg1Of expressed,that
R3218 T4125 T4124 arg2Of expressed,are
R3219 T4125 T4126 arg1Of expressed,on
R3220 T4129 T4126 arg2Of B-cells,on
R3221 T4129 T4127 arg1Of B-cells,resting
R3222 T4129 T4128 arg1Of B-cells,human
R3223 T4129 T4130 arg1Of B-cells,(
R3224 T4131 T4130 arg2Of Figure,(
R3225 T4131 T4132 arg1Of Figure,4
R3226 T4133 T4130 arg3Of ),(
R3227 T4135 T4134 arg1Of cells,Ramos
R3228 T4135 T4136 arg1Of cells,expressed
R3229 T4136 T4152 arg1Of expressed,but
R3230 T4136 T4154 arg1Of expressed,weakly
R3231 T4141 T4137 arg1Of Act-RIA,the
R3232 T4141 T4138 arg1Of Act-RIA,type
R3233 T4141 T4139 arg1Of Act-RIA,I
R3234 T4141 T4140 arg1Of Act-RIA,receptors
R3235 T4141 T4142 arg1Of Act-RIA,","
R3236 T4142 T4145 arg1Of ",",and
R3237 T4144 T4142 arg2Of BMP-RIB,","
R3238 T4144 T4143 arg1Of BMP-RIB,weakly
R3239 T4145 T4136 arg2Of and,expressed
R3240 T4150 T4145 arg2Of BMP-RII,and
R3241 T4150 T4146 arg1Of BMP-RII,the
R3242 T4150 T4147 arg1Of BMP-RII,type
R3243 T4150 T4148 arg1Of BMP-RII,II
R3244 T4150 T4149 arg1Of BMP-RII,receptor
R3245 T4152 T4151 arg1Of but,","
R3246 T4154 T4153 arg1Of weakly,more
R3247 T4154 T4155 arg1Of weakly,than
R3248 T4158 T4155 arg2Of cells,than
R3249 T4158 T4156 arg1Of cells,normal
R3250 T4158 T4157 arg1Of cells,B
R3251 T4158 T4159 arg1Of cells,(
R3252 T4160 T4159 arg2Of Figure,(
R3253 T4160 T4161 arg1Of Figure,4
R3254 T4162 T4159 arg3Of ),(
R3255 T4164 T4163 arg1Of cells,HL60
R3256 T4164 T4165 arg1Of cells,were
R3257 T4164 T4166 arg2Of cells,used
R3258 T4166 T4165 arg2Of used,were
R3259 T4166 T4167 arg1Of used,for
R3260 T4168 T4169 arg1Of comparison,and
R3261 T4169 T4167 arg2Of and,for
R3262 T4172 T4173 arg1Of Act-RIA,and
R3263 T4173 T4169 arg2Of and,and
R3264 T4173 T4170 arg1Of and,weakly
R3265 T4173 T4171 arg2Of and,expressed
R3266 T4174 T4173 arg2Of BMP-RII,and
R3267 T4175 T4176 arg1Of Taken,together
R3268 T4179 T4178 arg1Of data,these
R3269 T4179 T4180 arg1Of data,show
R3270 T4180 T4175 modOf show,Taken
R3271 T4180 T4177 arg1Of show,","
R3272 T4185 T4182 arg1Of cells,normal
R3273 T4185 T4183 arg1Of cells,human
R3274 T4185 T4184 arg1Of cells,B
R3275 T4185 T4186 arg1Of cells,and
R3276 T4186 T4189 arg1Of and,express
R3277 T4188 T4186 arg2Of cells,and
R3278 T4188 T4187 arg1Of cells,Ramos
R3279 T4189 T4180 arg2Of express,show
R3280 T4189 T4181 arg1Of express,that
R3281 T4191 T4189 arg2Of set,express
R3282 T4191 T4190 arg1Of set,a
R3283 T4191 T4192 arg1Of set,of
R3284 T4191 T4195 arg1Of set,","
R3285 T4191 T4196 arg1Of set,previously
R3286 T4191 T4197 arg2Of set,shown
R3287 T4191 T4199 arg1Of set,bind
R3288 T4194 T4192 arg2Of receptors,of
R3289 T4194 T4193 arg1Of receptors,BMP
R3290 T4199 T4197 arg3Of bind,shown
R3291 T4199 T4198 arg1Of bind,to
R3292 T4199 T4201 arg1Of bind,[
R3293 T4200 T4199 arg2Of BMP-6,bind
R3294 T4202 T4201 arg2Of 16,[
R3295 T4203 T4201 arg3Of ],[
R3561 T4625 T4626 arg1Of BMP-6,induces
R3562 T4627 T4626 arg2Of phosphorylation,induces
R3563 T4627 T4628 arg1Of phosphorylation,of
R3564 T4629 T4628 arg2Of Smad1/5/8,of
R3565 T4632 T4630 arg2Of binding,Upon
R3566 T4632 T4631 arg1Of binding,ligand
R3567 T4637 T4634 arg1Of receptor,the
R3568 T4637 T4635 arg1Of receptor,type
R3569 T4637 T4636 arg1Of receptor,II
R3570 T4637 T4638 arg1Of receptor,transphosphorylates
R3571 T4637 T4640 arg1Of receptor,activates
R3572 T4638 T4639 arg1Of transphosphorylates,and
R3573 T4639 T4630 arg1Of and,Upon
R3574 T4639 T4633 arg1Of and,","
R3575 T4640 T4639 arg2Of activates,and
R3576 T4644 T4638 arg2Of receptor,transphosphorylates
R3577 T4644 T4640 arg2Of receptor,activates
R3578 T4644 T4641 arg1Of receptor,the
R3579 T4644 T4642 arg1Of receptor,type
R3580 T4644 T4643 arg1Of receptor,I
R3581 T4647 T4645 arg1Of receptors,Type
R3582 T4647 T4646 arg1Of receptors,I
R3583 T4647 T4648 arg1Of receptors,can
R3584 T4647 T4649 arg1Of receptors,signal
R3585 T4649 T4648 arg2Of signal,can
R3586 T4649 T4650 arg1Of signal,via
R3587 T4652 T4650 arg2Of pathways,via
R3588 T4652 T4651 arg1Of pathways,several
R3589 T4653 T4654 arg1Of We,examined
R3590 T4654 T4662 arg1Of examined,","
R3591 T4654 T4663 arg1Of examined,as
R3592 T4656 T4654 arg2Of effect,examined
R3593 T4656 T4655 arg1Of effect,the
R3594 T4656 T4657 arg1Of effect,of
R3595 T4656 T4659 arg1Of effect,on
R3596 T4658 T4657 arg2Of BMP-6,of
R3597 T4661 T4659 arg2Of phosphorylation,on
R3598 T4661 T4660 arg1Of phosphorylation,Smad
R3599 T4665 T4664 arg1Of activation,the
R3600 T4665 T4666 arg1Of activation,of
R3601 T4665 T4668 arg1Of activation,is
R3602 T4665 T4669 arg2Of activation,considered
R3603 T4665 T4671 arg1Of activation,be
R3604 T4667 T4666 arg2Of Smad,of
R3605 T4669 T4663 arg2Of considered,as
R3606 T4669 T4668 arg2Of considered,is
R3607 T4671 T4669 arg3Of be,considered
R3608 T4671 T4670 arg1Of be,to
R3609 T4675 T4671 arg2Of pathway,be
R3610 T4675 T4672 arg1Of pathway,a
R3611 T4675 T4673 arg1Of pathway,major
R3612 T4675 T4674 arg1Of pathway,signalling
R3613 T4675 T4676 arg1Of pathway,for
R3614 T4677 T4676 arg2Of BMPs,for
R3615 T4677 T4678 arg1Of BMPs,[
R3616 T4679 T4678 arg2Of 17,[
R3617 T4680 T4678 arg3Of ],[
R3618 T4682 T4681 arg1Of cells,B
R3619 T4682 T4683 arg1Of cells,were
R3620 T4682 T4684 arg2Of cells,cultured
R3621 T4682 T4692 arg2Of cells,treated
R3622 T4684 T4685 arg1Of cultured,in
R3623 T4684 T4690 arg1Of cultured,and
R3624 T4687 T4685 arg2Of media,in
R3625 T4687 T4686 arg1Of media,serum-free
R3626 T4687 T4688 arg1Of media,over
R3627 T4689 T4688 arg2Of night,over
R3628 T4690 T4683 arg2Of and,were
R3629 T4692 T4690 arg2Of treated,and
R3630 T4692 T4691 arg1Of treated,then
R3631 T4692 T4693 arg1Of treated,with
R3632 T4694 T4693 arg2Of BMP-6,with
R3633 T4694 T4695 arg1Of BMP-6,for
R3634 T4698 T4695 arg2Of points,for
R3635 T4698 T4696 arg1Of points,various
R3636 T4698 T4697 arg1Of points,time
R3637 T4701 T4699 arg1Of lysates,Total
R3638 T4701 T4700 arg1Of lysates,protein
R3639 T4701 T4702 arg1Of lysates,were
R3640 T4701 T4703 arg2Of lysates,prepared
R3641 T4703 T4702 arg2Of prepared,were
R3642 T4703 T4705 arg1Of prepared,and
R3643 T4705 T4704 arg1Of and,","
R3644 T4707 T4706 arg1Of amounts,the
R3645 T4707 T4708 arg1Of amounts,of
R3646 T4707 T4714 arg1Of amounts,were
R3647 T4707 T4715 arg2Of amounts,determined
R3648 T4711 T4708 arg2Of forms,of
R3649 T4711 T4709 arg1Of forms,the
R3650 T4711 T4710 arg1Of forms,phosphorylated
R3651 T4711 T4712 arg1Of forms,of
R3652 T4713 T4712 arg2Of Smad1/5/8,of
R3653 T4715 T4705 arg2Of determined,and
R3654 T4715 T4714 arg2Of determined,were
R3655 T4719 T4715 arg1Of analysis,determined
R3656 T4719 T4716 arg2Of analysis,by
R3657 T4719 T4717 arg1Of analysis,western
R3658 T4719 T4718 arg1Of analysis,blot
R3659 T4722 T4723 arg1Of treatment,with
R3660 T4722 T4727 arg1Of treatment,induced
R3661 T4724 T4725 arg1Of 500,ng/ml
R3662 T4726 T4723 arg2Of BMP-6,with
R3663 T4726 T4724 arg1Of BMP-6,500
R3664 T4728 T4727 arg2Of phosphorylation,induced
R3665 T4728 T4729 arg1Of phosphorylation,of
R3666 T4728 T4732 arg1Of phosphorylation,BMP-6
R3667 T4730 T4729 arg2Of Smad.,of
R3668 T4732 T4731 arg1Of BMP-6,The
R3669 T4734 T4733 arg2Of phosphorylation,induced
R3670 T4734 T4735 arg1Of phosphorylation,was
R3671 T4734 T4736 arg1Of phosphorylation,high
R3672 T4734 T4749 arg1Of phosphorylation,remained
R3673 T4734 T4750 arg1Of phosphorylation,high
R3674 T4735 T4737 arg1Of was,at
R3675 T4735 T4748 arg1Of was,and
R3676 T4736 T4735 arg2Of high,was
R3677 T4741 T4737 arg2Of point,at
R3678 T4741 T4738 arg1Of point,the
R3679 T4741 T4739 arg1Of point,earliest
R3680 T4741 T4740 arg1Of point,time
R3681 T4741 T4742 arg2Of point,tested
R3682 T4742 T4743 arg1Of tested,(
R3683 T4745 T4743 arg2Of minutes,(
R3684 T4745 T4744 arg1Of minutes,15
R3685 T4746 T4743 arg3Of ),(
R3686 T4748 T4720 arg1Of and,Interestingly
R3687 T4748 T4721 arg1Of and,","
R3688 T4748 T4727 arg3Of and,induced
R3689 T4748 T4747 arg1Of and,","
R3690 T4749 T4748 arg2Of remained,and
R3691 T4749 T4751 arg1Of remained,for
R3692 T4750 T4749 arg2Of high,remained
R3693 T4754 T4752 arg1Of 48,at
R3694 T4754 T4753 arg1Of 48,least
R3695 T4755 T4751 arg2Of hours,for
R3696 T4755 T4754 arg1Of hours,48
R3697 T4755 T4756 arg1Of hours,(
R3698 T4757 T4756 arg2Of Figure,(
R3699 T4757 T4758 arg1Of Figure,5
R3700 T4759 T4756 arg3Of ),(
R3701 T4762 T4760 arg1Of phosphorylation,A
R3702 T4762 T4761 arg1Of phosphorylation,similar
R3703 T4762 T4763 arg1Of phosphorylation,was
R3704 T4762 T4764 arg2Of phosphorylation,observed
R3705 T4764 T4763 arg2Of observed,was
R3706 T4764 T4765 arg1Of observed,in
R3707 T4764 T4771 arg1Of observed,in
R3708 T4765 T4769 arg1Of in,but
R3709 T4767 T4765 arg2Of cells,in
R3710 T4767 T4766 arg1Of cells,Ramos
R3711 T4769 T4768 arg1Of but,","
R3712 T4771 T4769 arg2Of in,but
R3713 T4771 T4770 arg1Of in,not
R3714 T4773 T4771 arg2Of cells,in
R3715 T4773 T4772 arg1Of cells,HL60
R3716 T4773 T4774 arg1Of cells,(
R3717 T4775 T4774 arg2Of Figure,(
R3718 T4775 T4776 arg1Of Figure,6
R3719 T4777 T4774 arg3Of ),(
R3720 T4780 T4782 arg1Of we,tested
R3721 T4782 T4778 arg1Of tested,Furthermore
R3722 T4782 T4779 arg1Of tested,","
R3723 T4782 T4781 arg1Of tested,also
R3724 T4788 T4784 arg1Of pathways,other
R3725 T4788 T4785 arg2Of pathways,known
R3726 T4788 T4786 arg1Of pathways,downstream
R3727 T4788 T4787 arg1Of pathways,signalling
R3728 T4788 T4789 arg1Of pathways,of
R3729 T4788 T4791 arg1Of pathways,could
R3730 T4788 T4792 arg1Of pathways,be
R3731 T4788 T4793 arg2Of pathways,triggered
R3732 T4790 T4789 arg2Of BMP-6,of
R3733 T4793 T4782 arg2Of triggered,tested
R3734 T4793 T4783 arg1Of triggered,whether
R3735 T4793 T4791 arg2Of triggered,could
R3736 T4793 T4792 arg2Of triggered,be
R3737 T4795 T4793 arg1Of BMP-6,triggered
R3738 T4795 T4794 arg2Of BMP-6,by
R3739 T4795 T4796 arg1Of BMP-6,in
R3740 T4799 T4796 arg2Of cells,in
R3741 T4799 T4797 arg1Of cells,human
R3742 T4799 T4798 arg1Of cells,B
R3743 T4802 T4803 arg1Of we,did
R3744 T4802 T4805 arg1Of we,observe
R3745 T4805 T4800 arg1Of observe,However
R3746 T4805 T4801 arg1Of observe,","
R3747 T4805 T4803 arg2Of observe,did
R3748 T4805 T4804 arg1Of observe,not
R3749 T4805 T4816 arg1Of observe,upon
R3750 T4808 T4805 arg2Of changes,observe
R3751 T4808 T4806 arg1Of changes,any
R3752 T4808 T4807 arg1Of changes,significant
R3753 T4808 T4809 arg1Of changes,in
R3754 T4811 T4809 arg2Of level,in
R3755 T4811 T4810 arg1Of level,the
R3756 T4811 T4812 arg1Of level,of
R3757 T4813 T4814 arg1Of phospho-STAT3,or
R3758 T4814 T4812 arg2Of or,of
R3759 T4815 T4814 arg2Of phospho-p38,or
R3760 T4818 T4816 arg2Of treatment,upon
R3761 T4818 T4817 arg1Of treatment,BMP-6
R3762 T4818 T4819 arg1Of treatment,of
R3763 T4818 T4822 arg1Of treatment,(
R3764 T4821 T4819 arg2Of cells,of
R3765 T4821 T4820 arg1Of cells,B
R3766 T4823 T4822 arg2Of data,(
R3767 T4823 T4825 arg2Of data,shown
R3768 T4825 T4824 arg1Of shown,not
R3769 T4826 T4822 arg3Of ),(
R4242 T5461 T5462 arg1Of BMP-6,induces
R4243 T5463 T5462 arg2Of upregulation,induces
R4244 T5463 T5464 arg1Of upregulation,of
R4245 T5465 T5464 arg2Of Id1,of
R4246 T5466 T5471 arg2Of Next,explore
R4247 T5468 T5469 arg1Of we,wanted
R4248 T5468 T5471 arg1Of we,explore
R4249 T5469 T5467 arg1Of wanted,","
R4250 T5471 T5469 arg2Of explore,wanted
R4251 T5471 T5470 arg1Of explore,to
R4252 T5471 T5472 arg1Of explore,whether
R4253 T5475 T5474 arg1Of induced,BMP-6
R4254 T5476 T5473 arg1Of phosphorylation,the
R4255 T5476 T5475 arg1Of phosphorylation,induced
R4256 T5476 T5477 arg1Of phosphorylation,of
R4257 T5476 T5481 arg1Of phosphorylation,could
R4258 T5476 T5482 arg1Of phosphorylation,induce
R4259 T5478 T5477 arg2Of Smad,of
R4260 T5478 T5479 arg1Of Smad,1/5/8
R4261 T5482 T5472 arg2Of induce,whether
R4262 T5482 T5480 arg1Of induce,also
R4263 T5482 T5481 arg2Of induce,could
R4264 T5484 T5482 arg2Of changes,induce
R4265 T5484 T5483 arg1Of changes,transcriptional
R4266 T5484 T5485 arg1Of changes,of
R4267 T5487 T5485 arg2Of genes,of
R4268 T5487 T5486 arg1Of genes,target
R4269 T5490 T5488 arg2Of regard,In
R4270 T5490 T5489 arg1Of regard,this
R4271 T5493 T5492 arg1Of inhibitors,the
R4272 T5493 T5494 arg1Of inhibitors,of
R4273 T5493 T5501 arg1Of inhibitors,are
R4274 T5493 T5502 arg2Of inhibitors,considered
R4275 T5493 T5504 arg1Of inhibitors,be
R4276 T5497 T5494 arg2Of proteins,of
R4277 T5497 T5495 arg1Of proteins,DNA
R4278 T5497 T5496 arg1Of proteins,binding
R4279 T5497 T5498 arg1Of proteins,(
R4280 T5499 T5498 arg2Of Ids,(
R4281 T5500 T5498 arg3Of ),(
R4282 T5502 T5488 arg1Of considered,In
R4283 T5502 T5491 arg1Of considered,","
R4284 T5502 T5501 arg2Of considered,are
R4285 T5504 T5502 arg3Of be,considered
R4286 T5504 T5503 arg1Of be,to
R4287 T5504 T5511 arg1Of be,for
R4288 T5505 T5504 arg2Of some,be
R4289 T5505 T5506 arg1Of some,of
R4290 T5510 T5506 arg2Of genes,of
R4291 T5510 T5507 arg1Of genes,the
R4292 T5510 T5508 arg1Of genes,major
R4293 T5510 T5509 arg1Of genes,target
R4294 T5512 T5511 arg2Of Smad-signalling,for
R4295 T5512 T5513 arg1Of Smad-signalling,[
R4296 T5514 T5513 arg2Of 17,[
R4297 T5515 T5513 arg3Of ],[
R4298 T5519 T5518 arg1Of cells,B
R4299 T5519 T5520 arg1Of cells,were
R4300 T5519 T5521 arg2Of cells,pre-incubated
R4301 T5519 T5530 arg2Of cells,cultured
R4302 T5521 T5522 arg1Of pre-incubated,over
R4303 T5521 T5524 arg1Of pre-incubated,in
R4304 T5521 T5528 arg1Of pre-incubated,and
R4305 T5523 T5522 arg2Of night,over
R4306 T5525 T5524 arg2Of X-VIVO,in
R4307 T5525 T5526 arg1Of X-VIVO,15
R4308 T5528 T5516 arg1Of and,Thus
R4309 T5528 T5517 arg1Of and,","
R4310 T5528 T5520 arg2Of and,were
R4311 T5528 T5527 arg1Of and,","
R4312 T5530 T5528 arg2Of cultured,and
R4313 T5530 T5529 arg1Of cultured,then
R4314 T5530 T5531 arg1Of cultured,in
R4315 T5530 T5544 arg1Of cultured,before
R4316 T5532 T5531 arg2Of medium,in
R4317 T5532 T5533 arg1Of medium,alone
R4318 T5532 T5535 arg1Of medium,in
R4319 T5532 T5540 arg1Of medium,for
R4320 T5533 T5534 arg1Of alone,or
R4321 T5535 T5534 arg2Of in,or
R4322 T5537 T5535 arg2Of presence,in
R4323 T5537 T5536 arg1Of presence,the
R4324 T5537 T5538 arg1Of presence,of
R4325 T5539 T5538 arg2Of BMP-6,of
R4326 T5543 T5540 arg2Of points,for
R4327 T5543 T5541 arg1Of points,various
R4328 T5543 T5542 arg1Of points,time
R4329 T5545 T5544 arg2Of preparation,before
R4330 T5545 T5546 arg1Of preparation,of
R4331 T5548 T5546 arg2Of RNA,of
R4332 T5548 T5547 arg1Of RNA,total
R4333 T5550 T5549 arg1Of amount,The
R4334 T5550 T5551 arg1Of amount,of
R4335 T5550 T5554 arg1Of amount,was
R4336 T5550 T5555 arg2Of amount,quantified
R4337 T5553 T5551 arg2Of mRNA,of
R4338 T5553 T5552 arg1Of mRNA,Id1–Id4
R4339 T5555 T5554 arg2Of quantified,was
R4340 T5558 T5555 arg1Of RT-PCR,quantified
R4341 T5558 T5556 arg2Of RT-PCR,by
R4342 T5558 T5557 arg1Of RT-PCR,real-time
R4343 T5561 T5562 arg1Of we,observed
R4344 T5562 T5559 arg1Of observed,Interestingly
R4345 T5562 T5560 arg1Of observed,","
R4346 T5562 T5570 arg1Of observed,in
R4347 T5566 T5562 arg2Of upregulation,observed
R4348 T5566 T5563 arg1Of upregulation,a
R4349 T5566 T5564 arg1Of upregulation,specific
R4350 T5566 T5565 arg1Of upregulation,four-fold
R4351 T5566 T5567 arg1Of upregulation,of
R4352 T5569 T5567 arg2Of mRNA,of
R4353 T5569 T5568 arg1Of mRNA,Id1
R4354 T5573 T5570 arg2Of cells,in
R4355 T5573 T5571 arg1Of cells,BMP-6-treated
R4356 T5573 T5572 arg1Of cells,B
R4357 T5573 T5574 arg1Of cells,(
R4358 T5575 T5574 arg2Of Figure,(
R4359 T5575 T5576 arg1Of Figure,7
R4360 T5577 T5574 arg3Of ),(
R4361 T5579 T5578 arg1Of up-regulation,The
R4362 T5579 T5580 arg1Of up-regulation,of
R4363 T5579 T5583 arg1Of up-regulation,was
R4364 T5579 T5584 arg1Of up-regulation,characteristic
R4365 T5579 T5602 arg1Of up-regulation,returned
R4366 T5582 T5580 arg2Of mRNA,of
R4367 T5582 T5581 arg1Of mRNA,Id1
R4368 T5583 T5590 arg1Of was,","
R4369 T5583 T5591 arg1Of was,with
R4370 T5583 T5596 arg1Of was,after
R4371 T5583 T5601 arg1Of was,and
R4372 T5584 T5583 arg2Of characteristic,was
R4373 T5584 T5585 arg1Of characteristic,of
R4374 T5589 T5585 arg2Of gene,of
R4375 T5589 T5586 arg1Of gene,an
R4376 T5589 T5587 arg1Of gene,early
R4377 T5589 T5588 arg1Of gene,inducible
R4378 T5595 T5591 arg2Of hours,with
R4379 T5595 T5592 arg1Of hours,maximal
R4380 T5595 T5593 arg1Of hours,upregulation
R4381 T5595 T5594 arg1Of hours,two
R4382 T5598 T5596 arg2Of addition,after
R4383 T5598 T5597 arg1Of addition,the
R4384 T5598 T5599 arg1Of addition,of
R4385 T5600 T5599 arg2Of BMP-6,of
R4386 T5602 T5601 arg2Of returned,and
R4387 T5602 T5603 arg1Of returned,to
R4388 T5602 T5605 arg1Of returned,after
R4389 T5604 T5603 arg2Of baseline,to
R4390 T5607 T5605 arg2Of hours,after
R4391 T5607 T5606 arg1Of hours,24
R4392 T5609 T5608 arg2Of contrast,In
R4393 T5613 T5611 arg1Of changes,no
R4394 T5613 T5612 arg1Of changes,significant
R4395 T5613 T5614 arg1Of changes,were
R4396 T5613 T5615 arg2Of changes,observed
R4397 T5615 T5608 arg1Of observed,In
R4398 T5615 T5610 arg1Of observed,","
R4399 T5615 T5614 arg2Of observed,were
R4400 T5615 T5616 arg1Of observed,for
R4401 T5615 T5621 arg1Of observed,","
R4402 T5615 T5622 arg1Of observed,whereas
R4403 T5617 T5618 arg1Of Id2,and
R4404 T5619 T5618 arg2Of Id3,and
R4405 T5620 T5616 arg2Of mRNA,for
R4406 T5620 T5617 arg1Of mRNA,Id2
R4407 T5620 T5619 arg1Of mRNA,Id3
R4408 T5623 T5624 arg1Of Id4-transcripts,were
R4409 T5623 T5626 arg1Of Id4-transcripts,detectable
R4410 T5624 T5622 arg2Of were,whereas
R4411 T5624 T5625 arg1Of were,not
R4412 T5626 T5624 arg2Of detectable,were
R4413 T5626 T5627 arg1Of detectable,(
R4414 T5628 T5629 arg1Of Figure,7
R4415 T5628 T5630 arg1Of Figure,","
R4416 T5630 T5627 arg2Of ",",(
R4417 T5630 T5633 arg2Of ",",shown
R4418 T5631 T5630 arg2Of data,","
R4419 T5633 T5632 arg1Of shown,not
R4420 T5634 T5627 arg3Of ),(
R4421 T5637 T5635 arg1Of analysis,Western
R4422 T5637 T5636 arg1Of analysis,blot
R4423 T5637 T5638 arg1Of analysis,revealed
R4424 T5642 T5640 arg1Of upregulation,the
R4425 T5642 T5641 arg1Of upregulation,BMP-6-induced
R4426 T5642 T5643 arg1Of upregulation,of
R4427 T5642 T5647 arg1Of upregulation,was
R4428 T5642 T5648 arg2Of upregulation,correlated
R4429 T5645 T5643 arg2Of mRNA,of
R4430 T5645 T5644 arg1Of mRNA,Id1
R4431 T5648 T5638 arg2Of correlated,revealed
R4432 T5648 T5639 arg1Of correlated,that
R4433 T5648 T5646 arg1Of correlated,also
R4434 T5648 T5647 arg2Of correlated,was
R4435 T5648 T5649 arg1Of correlated,with
R4436 T5648 T5655 arg1Of correlated,well
R4437 T5650 T5649 arg2Of upregulation,with
R4438 T5650 T5651 arg1Of upregulation,of
R4439 T5653 T5651 arg2Of protein,of
R4440 T5653 T5652 arg1Of protein,Id1
R4441 T5655 T5654 arg1Of well,as
R4442 T5657 T5656 arg1Of increase,The
R4443 T5657 T5658 arg1Of increase,in
R4444 T5657 T5662 arg1Of increase,was
R4445 T5657 T5663 arg1Of increase,detectable
R4446 T5657 T5668 arg1Of increase,increased
R4447 T5661 T5658 arg2Of level,in
R4448 T5661 T5659 arg1Of level,Id1
R4449 T5661 T5660 arg1Of level,protein
R4450 T5662 T5664 arg1Of was,after
R4451 T5662 T5667 arg1Of was,and
R4452 T5663 T5662 arg2Of detectable,was
R4453 T5666 T5664 arg2Of hour,after
R4454 T5666 T5665 arg1Of hour,one
R4455 T5667 T5675 arg1Of and,","
R4456 T5667 T5676 modOf and,showing
R4457 T5668 T5667 arg2Of increased,and
R4458 T5668 T5669 arg1Of increased,until
R4459 T5668 T5672 arg1Of increased,after
R4460 T5671 T5669 arg2Of hours,until
R4461 T5671 T5670 arg1Of hours,24
R4462 T5674 T5672 arg2Of addition,after
R4463 T5674 T5673 arg1Of addition,BMP-6
R4464 T5679 T5676 arg2Of upregulation,showing
R4465 T5679 T5677 arg1Of upregulation,a
R4466 T5679 T5678 arg1Of upregulation,16-fold
R4467 T5679 T5680 arg1Of upregulation,compared
R4468 T5681 T5680 arg2Of with,compared
R4469 T5682 T5681 arg2Of t0,with
R4470 T5682 T5683 arg1Of t0,(
R4471 T5682 T5692 arg1Of t0,(
R4472 T5685 T5683 arg2Of ≤,(
R4473 T5685 T5684 arg1Of ≤,p
R4474 T5685 T5686 arg1Of ≤,0.020
R4475 T5685 T5687 arg1Of ≤,","
R4476 T5688 T5687 arg2Of n,","
R4477 T5688 T5689 arg1Of n,=
R4478 T5688 T5690 arg1Of n,4
R4479 T5691 T5683 arg3Of ),(
R4480 T5693 T5694 arg1Of Figure,8
R4481 T5693 T5695 arg1Of Figure,and
R4482 T5695 T5692 arg2Of and,(
R4483 T5696 T5695 arg2Of 9,and
R4484 T5697 T5692 arg3Of ),(
R4485 T5699 T5698 arg2Of line,In
R4486 T5699 T5700 arg1Of line,with
R4487 T5703 T5700 arg2Of data,with
R4488 T5703 T5701 arg1Of data,the
R4489 T5703 T5702 arg1Of data,mRNA
R4490 T5707 T5705 arg1Of change,no
R4491 T5707 T5706 arg1Of change,consistent
R4492 T5707 T5708 arg1Of change,in
R4493 T5707 T5716 arg1Of change,could
R4494 T5707 T5717 arg1Of change,be
R4495 T5707 T5718 arg2Of change,observed
R4496 T5710 T5708 arg2Of amounts,in
R4497 T5710 T5709 arg1Of amounts,the
R4498 T5710 T5711 arg1Of amounts,of
R4499 T5712 T5713 arg1Of Id2,and
R4500 T5714 T5713 arg2Of Id3,and
R4501 T5715 T5711 arg2Of protein,of
R4502 T5715 T5712 arg1Of protein,Id2
R4503 T5715 T5714 arg1Of protein,Id3
R4504 T5718 T5698 arg1Of observed,In
R4505 T5718 T5704 arg1Of observed,","
R4506 T5718 T5716 arg2Of observed,could
R4507 T5718 T5717 arg2Of observed,be
R4508 T5718 T5719 arg1Of observed,(
R4509 T5720 T5721 arg1Of Figure,8
R4510 T5720 T5722 arg1Of Figure,and
R4511 T5722 T5719 arg2Of and,(
R4512 T5723 T5722 arg2Of 9,and
R4513 T5724 T5719 arg3Of ),(
R4514 T5725 T5726 arg1Of We,were
R4515 T5725 T5727 arg1Of We,able
R4516 T5725 T5729 arg1Of We,block
R4517 T5727 T5726 arg2Of able,were
R4518 T5729 T5727 arg2Of block,able
R4519 T5729 T5728 arg1Of block,to
R4520 T5729 T5734 arg1Of block,with
R4521 T5733 T5729 arg2Of band,block
R4522 T5733 T5730 arg1Of band,the
R4523 T5733 T5731 arg1Of band,Id1
R4524 T5733 T5732 arg1Of band,specific
R4525 T5737 T5734 arg2Of peptide,with
R4526 T5737 T5735 arg1Of peptide,a
R4527 T5737 T5736 arg1Of peptide,blocking
R4528 T5737 T5738 arg1Of peptide,(
R4529 T5739 T5738 arg2Of data,(
R4530 T5739 T5741 arg2Of data,shown
R4531 T5741 T5740 arg1Of shown,not
R4532 T5742 T5738 arg3Of ),(
R4533 T5743 T5744 arg1Of Taken,together
R4534 T5747 T5746 arg1Of data,these
R4535 T5747 T5748 arg1Of data,suggest
R4536 T5748 T5743 modOf suggest,Taken
R4537 T5748 T5745 arg1Of suggest,","
R4538 T5750 T5751 arg1Of Id1,could
R4539 T5750 T5752 arg1Of Id1,be
R4540 T5752 T5749 arg1Of be,that
R4541 T5752 T5751 arg2Of be,could
R4542 T5752 T5767 arg1Of be,","
R4543 T5752 T5768 arg1Of be,whereas
R4544 T5752 T5773 arg1Of be,seem
R4545 T5752 T5775 arg1Of be,be
R4546 T5752 T5776 arg2Of be,involved
R4547 T5756 T5752 arg2Of gene,be
R4548 T5756 T5753 arg1Of gene,a
R4549 T5756 T5754 arg1Of gene,possible
R4550 T5756 T5755 arg1Of gene,target
R4551 T5756 T5757 arg1Of gene,for
R4552 T5758 T5757 arg2Of mediating,for
R4553 T5760 T5758 arg2Of effects,mediating
R4554 T5760 T5759 arg1Of effects,the
R4555 T5760 T5761 arg1Of effects,of
R4556 T5760 T5763 arg1Of effects,in
R4557 T5762 T5761 arg2Of BMP-6,of
R4558 T5766 T5763 arg2Of cells,in
R4559 T5766 T5764 arg1Of cells,human
R4560 T5766 T5765 arg1Of cells,B
R4561 T5769 T5770 arg1Of Id2,and
R4562 T5770 T5768 arg2Of and,whereas
R4563 T5771 T5770 arg2Of Id3,and
R4564 T5773 T5748 arg2Of seem,suggest
R4565 T5773 T5772 arg1Of seem,not
R4566 T5776 T5773 arg2Of involved,seem
R4567 T5776 T5774 arg1Of involved,to
R4568 T5776 T5775 arg2Of involved,be
R5081 T6494 T6493 arg1Of production,BMP-6
R5082 T6494 T6495 arg1Of production,in
R5083 T6497 T6495 arg2Of cells,in
R5084 T6497 T6496 arg1Of cells,B
R5085 T6499 T6498 arg1Of fact,The
R5086 T6501 T6502 arg1Of BMP-6,has
R5087 T6501 T6503 arg1Of BMP-6,been
R5088 T6501 T6504 arg2Of BMP-6,reported
R5089 T6501 T6506 arg1Of BMP-6,act
R5090 T6501 T6522 arg1Of BMP-6,prompted
R5091 T6504 T6502 arg2Of reported,has
R5092 T6504 T6503 arg2Of reported,been
R5093 T6504 T6521 arg1Of reported,","
R5094 T6506 T6504 arg3Of act,reported
R5095 T6506 T6505 arg1Of act,to
R5096 T6506 T6507 arg1Of act,as
R5097 T6510 T6509 arg1Of stimulator,autocrine
R5098 T6510 T6511 arg1Of stimulator,in
R5099 T6510 T6516 arg1Of stimulator,and
R5100 T6512 T6511 arg2Of chondrocytes,in
R5101 T6512 T6513 arg1Of chondrocytes,[
R5102 T6514 T6513 arg2Of 18,[
R5103 T6515 T6513 arg3Of ],[
R5104 T6516 T6507 arg2Of and,as
R5105 T6516 T6508 arg1Of and,an
R5106 T6517 T6516 arg2Of ovarium,and
R5107 T6517 T6518 arg1Of ovarium,[
R5108 T6519 T6518 arg2Of 19,[
R5109 T6520 T6518 arg3Of ],[
R5110 T6521 T6499 arg2Of ",",fact
R5111 T6521 T6500 arg1Of ",",that
R5112 T6522 T6521 arg2Of prompted,","
R5113 T6523 T6522 arg2Of us,prompted
R5114 T6523 T6525 arg1Of us,investigate
R5115 T6525 T6522 arg3Of investigate,prompted
R5116 T6525 T6524 arg1Of investigate,to
R5117 T6530 T6527 arg1Of cells,normal
R5118 T6530 T6528 arg1Of cells,human
R5119 T6530 T6529 arg1Of cells,B
R5120 T6530 T6531 arg1Of cells,could
R5121 T6530 T6532 arg1Of cells,produce
R5122 T6532 T6525 arg2Of produce,investigate
R5123 T6532 T6526 arg1Of produce,whether
R5124 T6532 T6531 arg2Of produce,could
R5125 T6532 T6534 arg1Of produce,upon
R5126 T6533 T6532 arg2Of BMP-6,produce
R5127 T6535 T6534 arg2Of stimulation,upon
R5128 T6537 T6536 arg1Of cells,Ramos
R5129 T6537 T6538 arg1Of cells,","
R5130 T6537 T6539 arg1Of cells,which
R5131 T6537 T6540 arg1Of cells,have
R5132 T6537 T6541 arg1Of cells,been
R5133 T6537 T6542 arg2Of cells,described
R5134 T6537 T6544 arg1Of cells,express
R5135 T6537 T6552 arg1Of cells,and
R5136 T6542 T6540 arg2Of described,have
R5137 T6542 T6541 arg2Of described,been
R5138 T6544 T6542 arg3Of express,described
R5139 T6544 T6543 arg1Of express,to
R5140 T6544 T6547 arg1Of express,endogenously
R5141 T6544 T6548 arg1Of express,[
R5142 T6546 T6544 arg2Of mRNA,express
R5143 T6546 T6545 arg1Of mRNA,BMP-6
R5144 T6549 T6548 arg2Of 20,[
R5145 T6550 T6548 arg3Of ],[
R5146 T6552 T6551 arg1Of and,","
R5147 T6552 T6559 arg1Of and,served
R5148 T6557 T6552 arg2Of Jurkat,and
R5149 T6557 T6553 arg1Of Jurkat,the
R5150 T6557 T6554 arg1Of Jurkat,T
R5151 T6557 T6555 arg1Of Jurkat,cell
R5152 T6557 T6556 arg1Of Jurkat,line
R5153 T6559 T6558 arg1Of served,","
R5154 T6559 T6560 arg1Of served,as
R5155 T6559 T6565 arg1Of served,","
R5156 T6559 T6566 arg1Of served,respectively
R5157 T6561 T6562 arg1Of positive,and
R5158 T6563 T6562 arg2Of negative,and
R5159 T6564 T6560 arg2Of controls,as
R5160 T6564 T6561 arg1Of controls,positive
R5161 T6564 T6563 arg1Of controls,negative
R5162 T6570 T6567 arg1Of levels,Endogenous
R5163 T6570 T6568 arg1Of levels,BMP-6
R5164 T6570 T6569 arg1Of levels,mRNA
R5165 T6570 T6571 arg1Of levels,in
R5166 T6570 T6575 arg1Of levels,were
R5167 T6570 T6576 arg2Of levels,quantified
R5168 T6574 T6571 arg2Of cells,in
R5169 T6574 T6572 arg1Of cells,normal
R5170 T6574 T6573 arg1Of cells,B
R5171 T6576 T6575 arg2Of quantified,were
R5172 T6576 T6580 arg1Of quantified,after
R5173 T6579 T6576 arg1Of RT-PCR,quantified
R5174 T6579 T6577 arg2Of RT-PCR,by
R5175 T6579 T6578 arg1Of RT-PCR,real-time
R5176 T6581 T6580 arg2Of stimulation,after
R5177 T6581 T6582 arg1Of stimulation,with
R5178 T6583 T6582 arg2Of anti-IgM,with
R5179 T6583 T6584 arg1Of anti-IgM,for
R5180 T6587 T6584 arg2Of points,for
R5181 T6587 T6585 arg1Of points,different
R5182 T6587 T6586 arg1Of points,time
R5183 T6591 T6590 arg1Of up-regulation,the
R5184 T6591 T6592 arg1Of up-regulation,of
R5185 T6591 T6595 arg1Of up-regulation,was
R5186 T6591 T6596 arg1Of up-regulation,characteristic
R5187 T6594 T6592 arg2Of mRNA,of
R5188 T6594 T6593 arg1Of mRNA,BMP-6
R5189 T6595 T6588 arg1Of was,Interestingly
R5190 T6595 T6589 arg1Of was,","
R5191 T6596 T6595 arg2Of characteristic,was
R5192 T6596 T6597 arg1Of characteristic,of
R5193 T6601 T6599 arg1Of inducible,early-to
R5194 T6601 T6600 arg1Of inducible,intermediate
R5195 T6602 T6597 arg2Of gene,of
R5196 T6602 T6598 arg1Of gene,an
R5197 T6602 T6601 arg1Of gene,inducible
R5198 T6602 T6603 arg1Of gene,with
R5199 T6607 T6603 arg2Of hours,with
R5200 T6607 T6604 arg1Of hours,maximal
R5201 T6607 T6605 arg1Of hours,upregulation
R5202 T6607 T6606 arg1Of hours,four
R5203 T6607 T6608 arg1Of hours,after
R5204 T6610 T6608 arg2Of addition,after
R5205 T6610 T6609 arg1Of addition,the
R5206 T6610 T6611 arg1Of addition,of
R5207 T6612 T6611 arg2Of anti-IgM,of
R5208 T6614 T6613 arg1Of level,The
R5209 T6614 T6615 arg1Of level,of
R5210 T6614 T6618 arg1Of level,was
R5211 T6614 T6619 arg1Of level,back
R5212 T6617 T6615 arg2Of mRNA,of
R5213 T6617 T6616 arg1Of mRNA,BMP-6
R5214 T6618 T6622 arg1Of was,after
R5215 T6618 T6625 arg1Of was,upon
R5216 T6619 T6618 arg2Of back,was
R5217 T6619 T6620 arg1Of back,to
R5218 T6621 T6620 arg2Of baseline,to
R5219 T6624 T6622 arg2Of hours,after
R5220 T6624 T6623 arg1Of hours,24
R5221 T6626 T6625 arg2Of stimulation,upon
R5222 T6626 T6627 arg1Of stimulation,(
R5223 T6628 T6627 arg2Of Figure,(
R5224 T6628 T6629 arg1Of Figure,10
R5225 T6630 T6627 arg3Of ),(
R5226 T6634 T6635 arg1Of FCS,and
R5227 T6635 T6633 arg1Of and,both
R5228 T6635 T6638 arg1Of and,induced
R5229 T6637 T6635 arg2Of AB-serum,and
R5230 T6637 T6636 arg1Of AB-serum,human
R5231 T6638 T6631 arg1Of induced,Furthermore
R5232 T6638 T6632 arg1Of induced,","
R5233 T6640 T6638 arg2Of upregulation,induced
R5234 T6640 T6639 arg1Of upregulation,significant
R5235 T6640 T6641 arg1Of upregulation,of
R5236 T6643 T6641 arg2Of mRNA,of
R5237 T6643 T6642 arg1Of mRNA,BMP-6
R5238 T6643 T6644 arg1Of mRNA,(
R5239 T6645 T6644 arg2Of Figure,(
R5240 T6645 T6646 arg1Of Figure,11
R5241 T6647 T6644 arg3Of ),(
R5242 T6653 T6650 arg2Of study,in
R5243 T6653 T6651 arg1Of study,a
R5244 T6653 T6652 arg1Of study,separate
R5245 T6654 T6655 arg1Of we,have
R5246 T6654 T6656 arg1Of we,found
R5247 T6656 T6648 arg1Of found,Interestingly
R5248 T6656 T6649 arg1Of found,","
R5249 T6656 T6650 arg1Of found,in
R5250 T6656 T6655 arg2Of found,have
R5251 T6661 T6658 arg1Of cells,normal
R5252 T6661 T6659 arg1Of cells,human
R5253 T6661 T6660 arg1Of cells,T
R5254 T6661 T6662 arg1Of cells,do
R5255 T6661 T6664 arg1Of cells,express
R5256 T6664 T6656 arg2Of express,found
R5257 T6664 T6657 arg1Of express,that
R5258 T6664 T6662 arg2Of express,do
R5259 T6664 T6663 arg1Of express,not
R5260 T6664 T6667 arg1Of express,after
R5261 T6666 T6664 arg2Of mRNA,express
R5262 T6666 T6665 arg1Of mRNA,BMP-6
R5263 T6668 T6667 arg2Of activation,after
R5264 T6668 T6669 arg1Of activation,(
R5265 T6672 T6670 arg1Of al,Sivertsen
R5266 T6672 T6671 arg1Of al,et
R5267 T6672 T6673 arg1Of al,","
R5268 T6673 T6669 arg2Of ",",(
R5269 T6673 T6675 arg1Of ",",in
R5270 T6674 T6673 arg2Of manuscript,","
R5271 T6676 T6675 arg2Of preparation,in
R5272 T6677 T6669 arg3Of ),(
R5273 T6680 T6681 arg1Of we,wanted
R5274 T6680 T6683 arg1Of we,detect
R5275 T6681 T6678 arg1Of wanted,Next
R5276 T6681 T6679 arg1Of wanted,","
R5277 T6683 T6681 arg2Of detect,wanted
R5278 T6683 T6682 arg1Of detect,to
R5279 T6683 T6686 arg1Of detect,in
R5280 T6685 T6683 arg2Of protein,detect
R5281 T6685 T6684 arg1Of protein,BMP-6
R5282 T6688 T6687 arg1Of B-cells,normal
R5283 T6688 T6689 arg1Of B-cells,and
R5284 T6689 T6686 arg2Of and,in
R5285 T6693 T6692 arg1Of available,commercially
R5286 T6694 T6689 arg2Of antibodies,and
R5287 T6694 T6690 arg2Of antibodies,tested
R5288 T6694 T6691 arg1Of antibodies,various
R5289 T6694 T6693 arg1Of antibodies,available
R5290 T6699 T6697 arg2Of hands,in
R5291 T6699 T6698 arg1Of hands,our
R5292 T6702 T6700 arg1Of antibodies,these
R5293 T6702 T6701 arg1Of antibodies,anti-BMP-6
R5294 T6702 T6703 arg1Of antibodies,did
R5295 T6702 T6705 arg1Of antibodies,recognize
R5296 T6705 T6695 arg1Of recognize,However
R5297 T6705 T6696 arg1Of recognize,","
R5298 T6705 T6697 arg1Of recognize,in
R5299 T6705 T6703 arg2Of recognize,did
R5300 T6705 T6704 arg1Of recognize,only
R5301 T6709 T6706 arg1Of protein,the
R5302 T6709 T6707 arg1Of protein,recombinant
R5303 T6709 T6708 arg1Of protein,BMP-6
R5304 T6709 T6710 arg1Of protein,and
R5305 T6710 T6705 arg2Of and,recognize
R5306 T6714 T6710 arg2Of protein,and
R5307 T6714 T6711 arg1Of protein,not
R5308 T6714 T6712 arg1Of protein,the
R5309 T6714 T6713 arg1Of protein,native
R5970 T7966 T7965 arg1Of studies,Recent
R5971 T7966 T7967 arg1Of studies,have
R5972 T7966 T7968 arg1Of studies,demonstrated
R5973 T7968 T7967 arg2Of demonstrated,have
R5974 T7968 T7993 arg1Of demonstrated,but
R5975 T7971 T7970 arg1Of role,important
R5976 T7971 T7972 arg1Of role,for
R5977 T7971 T7976 arg1Of role,in
R5978 T7971 T7986 arg1Of role,and
R5979 T7975 T7972 arg2Of members,for
R5980 T7975 T7973 arg1Of members,BMP
R5981 T7975 T7974 arg1Of members,superfamily
R5982 T7979 T7977 arg1Of cells,hematopoietic
R5983 T7979 T7978 arg1Of cells,stem
R5984 T7979 T7980 arg1Of cells,","
R5985 T7980 T7976 arg2Of ",",in
R5986 T7982 T7980 arg2Of thymocytes,","
R5987 T7982 T7981 arg1Of thymocytes,early
R5988 T7982 T7983 arg1Of thymocytes,[
R5989 T7984 T7983 arg2Of "6,7",[
R5990 T7985 T7983 arg3Of ],[
R5991 T7986 T7968 arg2Of and,demonstrated
R5992 T7986 T7969 arg1Of and,an
R5993 T7988 T7986 arg2Of malignancies,and
R5994 T7988 T7987 arg1Of malignancies,B-cell
R5995 T7988 T7989 arg1Of malignancies,[
R5996 T7990 T7989 arg2Of "8,11,12",[
R5997 T7991 T7989 arg3Of ],[
R5998 T7993 T7992 arg1Of but,","
R5999 T7995 T7994 arg1Of role,a
R6000 T7995 T7996 arg1Of role,for
R6001 T7995 T8003 arg1Of role,has
R6002 T7995 T8006 arg1Of role,been
R6003 T7995 T8007 arg2Of role,reported
R6004 T7997 T7996 arg2Of BMPs,for
R6005 T7997 T7998 arg1Of BMPs,in
R6006 T8002 T7998 arg2Of cells,in
R6007 T8002 T7999 arg1Of cells,normal
R6008 T8002 T8000 arg1Of cells,human
R6009 T8002 T8001 arg1Of cells,B
R6010 T8007 T7993 arg2Of reported,but
R6011 T8007 T8003 arg2Of reported,has
R6012 T8007 T8004 arg1Of reported,previously
R6013 T8007 T8005 arg1Of reported,not
R6014 T8007 T8006 arg2Of reported,been
R6015 T8010 T8008 arg1Of study,The
R6016 T8010 T8009 arg1Of study,present
R6017 T8010 T8011 arg1Of study,demonstrated
R6018 T8014 T8013 arg1Of antiproliferative,significant
R6019 T8015 T8011 arg2Of effect,demonstrated
R6020 T8015 T8012 arg1Of effect,a
R6021 T8015 T8014 arg1Of effect,antiproliferative
R6022 T8015 T8016 arg1Of effect,of
R6023 T8015 T8018 arg1Of effect,in
R6024 T8017 T8016 arg2Of BMP-6,of
R6025 T8023 T8018 arg2Of cells,in
R6026 T8023 T8019 arg1Of cells,peripheral
R6027 T8023 T8020 arg1Of cells,blood
R6028 T8023 T8021 arg1Of cells,CD19+
R6029 T8023 T8022 arg1Of cells,B
R6030 T8026 T8027 arg1Of BMP-6,induced
R6031 T8027 T8024 arg1Of induced,Additionally
R6032 T8027 T8025 arg1Of induced,","
R6033 T8027 T8030 arg1Of induced,in
R6034 T8027 T8038 arg1Of induced,in
R6035 T8029 T8027 arg2Of death,induced
R6036 T8029 T8028 arg1Of death,cell
R6037 T8030 T8037 arg1Of in,as
R6038 T8034 T8030 arg2Of cells,in
R6039 T8034 T8031 arg1Of cells,CD27+
R6040 T8034 T8032 arg1Of cells,memory
R6041 T8034 T8033 arg1Of cells,B
R6042 T8037 T8035 arg1Of as,as
R6043 T8037 T8036 arg1Of as,well
R6044 T8038 T8037 arg2Of in,as
R6045 T8043 T8038 arg2Of line,in
R6046 T8043 T8039 arg1Of line,a
R6047 T8043 T8040 arg1Of line,Burkitt
R6048 T8043 T8041 arg1Of line,lymphoma
R6049 T8043 T8042 arg1Of line,cell
R6050 T8043 T8044 arg1Of line,(
R6051 T8045 T8044 arg2Of Ramos,(
R6052 T8046 T8044 arg3Of ),(
R6053 T8049 T8050 arg1Of BMP-6,induced
R6054 T8050 T8047 arg1Of induced,Importantly
R6055 T8050 T8048 arg1Of induced,","
R6056 T8052 T8053 arg1Of rapid,and
R6057 T8054 T8053 arg2Of marked,and
R6058 T8055 T8050 arg2Of increase,induced
R6059 T8055 T8051 arg1Of increase,a
R6060 T8055 T8052 arg1Of increase,rapid
R6061 T8055 T8054 arg1Of increase,marked
R6062 T8055 T8056 arg1Of increase,in
R6063 T8058 T8056 arg2Of phosphorylation,in
R6064 T8058 T8057 arg1Of phosphorylation,Smad-1/5/8
R6065 T8063 T8062 arg1Of induced,BMP-6
R6066 T8065 T8061 arg1Of phosphorylation,the
R6067 T8065 T8063 arg1Of phosphorylation,induced
R6068 T8065 T8064 arg1Of phosphorylation,Smad
R6069 T8065 T8066 arg1Of phosphorylation,was
R6070 T8065 T8067 arg2Of phosphorylation,followed
R6071 T8067 T8059 arg1Of followed,Furthermore
R6072 T8067 T8060 arg1Of followed,","
R6073 T8067 T8066 arg2Of followed,was
R6074 T8071 T8067 arg1Of upregulation,followed
R6075 T8071 T8068 arg2Of upregulation,by
R6076 T8071 T8069 arg1Of upregulation,a
R6077 T8071 T8070 arg1Of upregulation,selective
R6078 T8071 T8072 arg1Of upregulation,of
R6079 T8074 T8073 arg1Of mRNA,Id1
R6080 T8074 T8075 arg1Of mRNA,and
R6081 T8075 T8072 arg2Of and,of
R6082 T8078 T8075 arg2Of protein,and
R6083 T8078 T8076 arg1Of protein,subsequent
R6084 T8078 T8077 arg1Of protein,Id1
R6085 T8082 T8079 arg2Of study,In
R6086 T8082 T8080 arg1Of study,the
R6087 T8082 T8081 arg1Of study,present
R6088 T8087 T8084 arg1Of effect,the
R6089 T8087 T8085 arg2Of effect,demonstrated
R6090 T8087 T8086 arg1Of effect,antiproliferative
R6091 T8087 T8088 arg1Of effect,of
R6092 T8087 T8090 arg1Of effect,in
R6093 T8087 T8095 arg1Of effect,was
R6094 T8087 T8096 arg1Of effect,significant
R6095 T8087 T8098 arg1Of effect,dose-dependent
R6096 T8089 T8088 arg2Of BMP-6,of
R6097 T8094 T8090 arg2Of cells,in
R6098 T8094 T8091 arg1Of cells,anti-IgM
R6099 T8094 T8092 arg2Of cells,treated
R6100 T8094 T8093 arg1Of cells,B
R6101 T8095 T8079 arg1Of was,In
R6102 T8095 T8083 arg1Of was,","
R6103 T8096 T8097 arg1Of significant,and
R6104 T8097 T8095 arg2Of and,was
R6105 T8098 T8097 arg2Of dose-dependent,and
R6106 T8103 T8101 arg1Of effect,the
R6107 T8103 T8102 arg1Of effect,anti-proliferative
R6108 T8103 T8104 arg1Of effect,of
R6109 T8103 T8106 arg1Of effect,could
R6110 T8103 T8107 arg1Of effect,be
R6111 T8103 T8109 arg2Of effect,neutralized
R6112 T8103 T8118 arg1Of effect,Noggin.
R6113 T8105 T8104 arg2Of BMP-6,of
R6114 T8109 T8106 arg2Of neutralized,could
R6115 T8109 T8107 arg2Of neutralized,be
R6116 T8109 T8108 arg1Of neutralized,completely
R6117 T8109 T8117 arg1Of neutralized,","
R6118 T8112 T8109 arg1Of use,neutralized
R6119 T8112 T8110 arg2Of use,by
R6120 T8112 T8111 arg1Of use,the
R6121 T8112 T8113 arg1Of use,of
R6122 T8116 T8113 arg2Of inhibitor,of
R6123 T8116 T8114 arg1Of inhibitor,a
R6124 T8116 T8115 arg1Of inhibitor,natural
R6125 T8117 T8099 arg1Of ",",Importantly
R6126 T8117 T8100 arg1Of ",",","
R6127 T8117 T8125 arg1Of ",",","
R6128 T8117 T8126 modOf ",",showing
R6129 T8118 T8117 arg2Of Noggin.,","
R6130 T8119 T8120 arg1Of This,is
R6131 T8119 T8121 arg1Of This,in
R6132 T8120 T8118 arg2Of is,Noggin.
R6133 T8121 T8120 arg2Of in,is
R6134 T8122 T8121 arg2Of line,in
R6135 T8122 T8123 arg1Of line,with
R6136 T8124 T8123 arg2Of others,with
R6137 T8128 T8129 arg1Of Noggin,can
R6138 T8128 T8130 arg1Of Noggin,function
R6139 T8130 T8126 arg2Of function,showing
R6140 T8130 T8127 arg1Of function,that
R6141 T8130 T8129 arg2Of function,can
R6142 T8130 T8131 arg1Of function,as
R6143 T8130 T8135 arg1Of function,[
R6144 T8134 T8131 arg2Of antagonist,as
R6145 T8134 T8132 arg1Of antagonist,a
R6146 T8134 T8133 arg1Of antagonist,BMP-6
R6147 T8136 T8135 arg2Of "21,22",[
R6148 T8137 T8135 arg3Of ],[
R6149 T8139 T8138 arg2Of addition,In
R6150 T8142 T8141 arg1Of combination,the
R6151 T8142 T8143 arg1Of combination,of
R6152 T8142 T8151 arg1Of combination,neutralized
R6153 T8145 T8144 arg1Of BMP-RIB-Fc,soluble
R6154 T8145 T8146 arg1Of BMP-RIB-Fc,and
R6155 T8146 T8143 arg2Of and,of
R6156 T8149 T8146 arg2Of proteins,and
R6157 T8149 T8147 arg1Of proteins,BMP-RII-Fc
R6158 T8149 T8148 arg1Of proteins,fusion
R6159 T8151 T8138 arg1Of neutralized,In
R6160 T8151 T8140 arg1Of neutralized,","
R6161 T8151 T8150 arg1Of neutralized,also
R6162 T8154 T8151 arg2Of effect,neutralized
R6163 T8154 T8152 arg1Of effect,the
R6164 T8154 T8153 arg1Of effect,anti-proliferative
R6165 T8154 T8155 arg1Of effect,of
R6166 T8154 T8157 arg1Of effect,in
R6167 T8156 T8155 arg2Of BMP-6,of
R6168 T8160 T8157 arg2Of cells,in
R6169 T8160 T8158 arg1Of cells,human
R6170 T8160 T8159 arg1Of cells,B
R6171 T8164 T8163 arg1Of for,as
R6172 T8168 T8164 arg2Of members,for
R6173 T8168 T8165 arg1Of members,other
R6174 T8168 T8166 arg1Of members,TGF
R6175 T8168 T8167 arg1Of members,family
R6176 T8171 T8170 arg1Of effects,bifunctional
R6177 T8171 T8172 arg1Of effects,have
R6178 T8171 T8174 arg1Of effects,been
R6179 T8171 T8175 arg2Of effects,demonstrated
R6180 T8175 T8161 arg1Of demonstrated,Interestingly
R6181 T8175 T8162 arg1Of demonstrated,","
R6182 T8175 T8164 arg1Of demonstrated,for
R6183 T8175 T8169 arg1Of demonstrated,","
R6184 T8175 T8172 arg2Of demonstrated,have
R6185 T8175 T8173 arg1Of demonstrated,also
R6186 T8175 T8174 arg2Of demonstrated,been
R6187 T8175 T8176 arg1Of demonstrated,for
R6188 T8177 T8176 arg2Of BMPs,for
R6189 T8179 T8180 arg1Of several,of
R6190 T8179 T8183 arg1Of several,have
R6191 T8179 T8184 arg1Of several,been
R6192 T8179 T8185 arg2Of several,shown
R6193 T8179 T8187 arg1Of several,promote
R6194 T8182 T8180 arg2Of BMPs,of
R6195 T8182 T8181 arg1Of BMPs,the
R6196 T8185 T8178 arg2Of shown,Whereas
R6197 T8185 T8183 arg2Of shown,have
R6198 T8185 T8184 arg2Of shown,been
R6199 T8187 T8185 arg3Of promote,shown
R6200 T8187 T8186 arg1Of promote,to
R6201 T8187 T8189 arg1Of promote,in
R6202 T8188 T8187 arg2Of proliferation,promote
R6203 T8192 T8189 arg2Of types,in
R6204 T8192 T8190 arg1Of types,various
R6205 T8192 T8191 arg1Of types,cell
R6206 T8192 T8193 arg1Of types,including
R6207 T8194 T8193 arg2Of condrocytes,including
R6208 T8194 T8195 arg1Of condrocytes,[
R6209 T8196 T8195 arg2Of 23,[
R6210 T8197 T8195 arg3Of ],[
R6211 T8199 T8200 arg1Of liver,[
R6212 T8199 T8203 arg1Of liver,and
R6213 T8201 T8200 arg2Of 24,[
R6214 T8202 T8200 arg3Of ],[
R6215 T8203 T8216 arg1Of and,has
R6216 T8203 T8217 arg1Of and,been
R6217 T8203 T8218 arg2Of and,reported
R6218 T8205 T8204 arg1Of cells,granulosa
R6219 T8205 T8206 arg1Of cells,[
R6220 T8205 T8209 arg1Of cells,","
R6221 T8207 T8206 arg2Of 25,[
R6222 T8208 T8206 arg3Of ],[
R6223 T8209 T8203 arg2Of ",",and
R6224 T8211 T8210 arg1Of effects,antiproliferative
R6225 T8211 T8212 arg1Of effects,and
R6226 T8212 T8209 arg2Of and,","
R6227 T8213 T8212 arg2Of induction,and
R6228 T8213 T8214 arg1Of induction,of
R6229 T8215 T8214 arg2Of apoptosis,of
R6230 T8218 T8178 arg1Of reported,Whereas
R6231 T8218 T8198 arg1Of reported,","
R6232 T8218 T8216 arg2Of reported,has
R6233 T8218 T8217 arg2Of reported,been
R6234 T8218 T8219 arg1Of reported,for
R6235 T8220 T8221 arg1Of B,and
R6236 T8222 T8221 arg2Of T,and
R6237 T8224 T8219 arg2Of cells,for
R6238 T8224 T8220 arg1Of cells,B
R6239 T8224 T8222 arg1Of cells,T
R6240 T8224 T8223 arg1Of cells,lineage
R6241 T8226 T8225 arg1Of effects,Similar
R6242 T8226 T8227 arg1Of effects,as
R6243 T8226 T8240 arg1Of effects,were
R6244 T8226 T8241 arg2Of effects,demonstrated
R6245 T8228 T8227 arg2Of demonstrated,as
R6246 T8228 T8229 arg1Of demonstrated,for
R6247 T8230 T8229 arg2Of BMP-6,for
R6248 T8230 T8231 arg1Of BMP-6,on
R6249 T8234 T8231 arg2Of cells,on
R6250 T8234 T8232 arg1Of cells,human
R6251 T8234 T8233 arg1Of cells,B
R6252 T8234 T8235 arg1Of cells,in
R6253 T8238 T8235 arg2Of study,in
R6254 T8238 T8236 arg1Of study,the
R6255 T8238 T8237 arg1Of study,present
R6256 T8241 T8239 arg1Of demonstrated,","
R6257 T8241 T8240 arg2Of demonstrated,were
R6258 T8241 T8242 arg1Of demonstrated,for
R6259 T8243 T8244 arg1Of BMP-2,","
R6260 T8244 T8246 arg1Of ",",","
R6261 T8245 T8244 arg2Of 4,","
R6262 T8246 T8248 arg1Of ",",and
R6263 T8247 T8246 arg2Of 6,","
R6264 T8248 T8242 arg2Of and,for
R6265 T8248 T8250 arg1Of and,in
R6266 T8249 T8248 arg2Of -7,and
R6267 T8253 T8250 arg2Of cells,in
R6268 T8253 T8251 arg1Of cells,human
R6269 T8253 T8252 arg1Of cells,myeloma
R6270 T8253 T8254 arg1Of cells,[
R6271 T8255 T8254 arg2Of 9-11,[
R6272 T8256 T8254 arg3Of ],[
R6273 T8258 T8257 arg1Of members,Other
R6274 T8258 T8259 arg1Of members,of
R6275 T8258 T8262 arg1Of members,have
R6276 T8258 T8264 arg1Of members,been
R6277 T8258 T8265 arg2Of members,reported
R6278 T8258 T8267 arg1Of members,induce
R6279 T8258 T8270 arg1Of members,including
R6280 T8261 T8259 arg2Of BMP-family,of
R6281 T8261 T8260 arg1Of BMP-family,the
R6282 T8265 T8262 arg2Of reported,have
R6283 T8265 T8263 arg1Of reported,also
R6284 T8265 T8264 arg2Of reported,been
R6285 T8265 T8269 arg1Of reported,","
R6286 T8265 T8270 modOf reported,including
R6287 T8267 T8265 arg3Of induce,reported
R6288 T8267 T8266 arg1Of induce,to
R6289 T8268 T8267 arg2Of apoptosis,induce
R6290 T8270 T8271 arg1Of including,in
R6291 T8275 T8271 arg2Of cells,in
R6292 T8275 T8272 arg1Of cells,mouse
R6293 T8275 T8273 arg1Of cells,B
R6294 T8275 T8274 arg1Of cells,lineage
R6295 T8275 T8276 arg1Of cells,[
R6296 T8277 T8276 arg2Of 26,[
R6297 T8278 T8276 arg3Of ],[
R6298 T8281 T8282 arg1Of BMP-4,inhibits
R6299 T8282 T8279 arg1Of inhibits,Additionally
R6300 T8282 T8280 arg1Of inhibits,","
R6301 T8282 T8285 arg1Of inhibits,[
R6302 T8284 T8282 arg2Of proliferation,inhibits
R6303 T8284 T8283 arg1Of proliferation,thymocyte
R6304 T8286 T8285 arg2Of 6,[
R6305 T8287 T8285 arg3Of ],[
R6306 T8288 T8289 arg1Of Taken,together
R6307 T8292 T8291 arg1Of data,these
R6308 T8292 T8293 arg1Of data,suggest
R6309 T8293 T8288 modOf suggest,Taken
R6310 T8293 T8290 arg1Of suggest,","
R6311 T8296 T8295 arg1Of role,the
R6312 T8296 T8297 arg1Of role,of
R6313 T8296 T8299 arg1Of role,in
R6314 T8296 T8306 arg1Of role,is
R6315 T8296 T8310 arg1Of role,dependent
R6316 T8298 T8297 arg2Of BMPs,of
R6317 T8301 T8299 arg2Of regulation,in
R6318 T8301 T8300 arg1Of regulation,the
R6319 T8301 T8302 arg1Of regulation,of
R6320 T8303 T8304 arg1Of proliferation,and
R6321 T8304 T8302 arg2Of and,of
R6322 T8305 T8304 arg2Of apoptosis,and
R6323 T8306 T8293 arg2Of is,suggest
R6324 T8306 T8294 arg1Of is,that
R6325 T8310 T8306 arg2Of dependent,is
R6326 T8310 T8307 arg1Of dependent,highly
R6327 T8310 T8308 arg1Of dependent,cell
R6328 T8310 T8309 arg1Of dependent,type
R6329 T8312 T8311 arg1Of examine,To
R6330 T8313 T8312 arg2Of how,examine
R6331 T8314 T8315 arg1Of BMP-6,exerts
R6332 T8315 T8313 arg1Of exerts,how
R6333 T8315 T8319 arg1Of exerts,in
R6334 T8318 T8315 arg2Of effects,exerts
R6335 T8318 T8316 arg1Of effects,its
R6336 T8318 T8317 arg1Of effects,functional
R6337 T8321 T8319 arg2Of cells,in
R6338 T8321 T8320 arg1Of cells,B
R6339 T8323 T8312 arg1Of we,examine
R6340 T8323 T8324 arg1Of we,analysed
R6341 T8324 T8311 modOf analysed,To
R6342 T8324 T8322 arg1Of analysed,","
R6343 T8324 T8328 arg1Of analysed,by
R6344 T8327 T8324 arg2Of expression,analysed
R6345 T8327 T8325 arg1Of expression,BMP
R6346 T8327 T8326 arg1Of expression,receptor
R6347 T8331 T8328 arg2Of analysis,by
R6348 T8331 T8329 arg1Of analysis,western
R6349 T8331 T8330 arg1Of analysis,blot
R6350 T8335 T8332 arg1Of cells,Human
R6351 T8335 T8333 arg1Of cells,peripheral
R6352 T8335 T8334 arg1Of cells,B
R6353 T8335 T8336 arg1Of cells,were
R6354 T8335 T8337 arg2Of cells,found
R6355 T8335 T8339 arg1Of cells,express
R6356 T8337 T8336 arg2Of found,were
R6357 T8339 T8337 arg3Of express,found
R6358 T8339 T8338 arg1Of express,to
R6359 T8345 T8346 arg1Of Act-RIA,and
R6360 T8346 T8340 arg1Of and,the
R6361 T8346 T8341 arg1Of and,BMP
R6362 T8346 T8342 arg1Of and,type
R6363 T8346 T8343 arg1Of and,I
R6364 T8346 T8344 arg1Of and,receptors
R6365 T8346 T8349 arg1Of and,and
R6366 T8347 T8346 arg2Of BMP-RIB,and
R6367 T8349 T8339 arg2Of and,express
R6368 T8349 T8348 arg1Of and,","
R6369 T8352 T8350 arg1Of II-receptors,the
R6370 T8352 T8351 arg1Of II-receptors,type
R6371 T8353 T8354 arg1Of BMP-RII,and
R6372 T8354 T8349 arg2Of and,and
R6373 T8354 T8352 arg1Of and,II-receptors
R6374 T8354 T8356 arg1Of and,","
R6375 T8354 T8357 arg1Of and,which
R6376 T8354 T8358 arg1Of and,signal
R6377 T8355 T8354 arg2Of Act-RIIb,and
R6378 T8358 T8359 arg1Of signal,after
R6379 T8360 T8359 arg2Of binding,after
R6380 T8360 T8361 arg1Of binding,of
R6381 T8363 T8361 arg2Of BMPs,of
R6382 T8363 T8362 arg1Of BMPs,several
R6383 T8363 T8364 arg1Of BMPs,","
R6384 T8363 T8365 arg1Of BMPs,including
R6385 T8366 T8365 arg2Of BMP-6,including
R6386 T8366 T8367 arg1Of BMP-6,[
R6387 T8368 T8367 arg2Of "16,13",[
R6388 T8369 T8367 arg3Of ],[
R6389 T8372 T8370 arg1Of explore,To
R6390 T8372 T8371 arg1Of explore,further
R6391 T8372 T8374 arg1Of explore,induced
R6392 T8373 T8372 arg2Of BMP-6,explore
R6393 T8374 T8376 arg1Of induced,","
R6394 T8375 T8374 arg2Of signalling,induced
R6395 T8377 T8378 arg1Of activation,of
R6396 T8377 T8381 arg1Of activation,is
R6397 T8377 T8382 arg1Of activation,possible
R6398 T8380 T8378 arg2Of pathways,of
R6399 T8380 T8379 arg1Of pathways,several
R6400 T8381 T8376 arg2Of is,","
R6401 T8382 T8381 arg2Of possible,is
R6402 T8386 T8383 arg1Of pathway,The
R6403 T8386 T8384 arg1Of pathway,major
R6404 T8386 T8385 arg1Of pathway,signalling
R6405 T8386 T8387 arg2Of pathway,known
R6406 T8386 T8391 arg1Of pathway,is
R6407 T8387 T8388 arg1Of known,to
R6408 T8389 T8388 arg2Of date,to
R6409 T8391 T8390 arg1Of is,","
R6410 T8392 T8391 arg2Of activation,is
R6411 T8392 T8393 arg1Of activation,of
R6412 T8394 T8393 arg2Of R-Smads,of
R6413 T8394 T8395 arg1Of R-Smads,[
R6414 T8396 T8395 arg2Of "13,27",[
R6415 T8397 T8395 arg3Of ],[
R6416 T8400 T8398 arg2Of respect,In
R6417 T8400 T8399 arg1Of respect,that
R6418 T8402 T8403 arg1Of BMPs,have
R6419 T8402 T8404 arg1Of BMPs,been
R6420 T8402 T8405 arg2Of BMPs,shown
R6421 T8402 T8407 arg1Of BMPs,exert
R6422 T8405 T8398 arg1Of shown,In
R6423 T8405 T8401 arg1Of shown,","
R6424 T8405 T8403 arg2Of shown,have
R6425 T8405 T8404 arg2Of shown,been
R6426 T8407 T8405 arg3Of exert,shown
R6427 T8407 T8406 arg1Of exert,to
R6428 T8407 T8410 arg1Of exert,in
R6429 T8407 T8414 arg1Of exert,via
R6430 T8409 T8407 arg2Of effects,exert
R6431 T8409 T8408 arg1Of effects,antiproliferative
R6432 T8413 T8410 arg2Of cells,in
R6433 T8413 T8411 arg1Of cells,B
R6434 T8413 T8412 arg1Of cells,lineage
R6435 T8415 T8414 arg2Of phosphorylation,via
R6436 T8415 T8416 arg1Of phosphorylation,of
R6437 T8417 T8416 arg2Of R-Smad,of
R6438 T8417 T8418 arg1Of R-Smad,[
R6439 T8419 T8418 arg2Of "11,28",[
R6440 T8420 T8418 arg3Of ],[
R6441 T8423 T8424 arg1Of BMP-2,has
R6442 T8423 T8425 arg1Of BMP-2,been
R6443 T8423 T8426 arg2Of BMP-2,shown
R6444 T8423 T8428 arg1Of BMP-2,induce
R6445 T8426 T8421 arg1Of shown,Furthermore
R6446 T8426 T8422 arg1Of shown,","
R6447 T8426 T8424 arg2Of shown,has
R6448 T8426 T8425 arg2Of shown,been
R6449 T8428 T8426 arg3Of induce,shown
R6450 T8428 T8427 arg1Of induce,to
R6451 T8428 T8435 arg1Of induce,[
R6452 T8429 T8428 arg2Of activation,induce
R6453 T8429 T8430 arg1Of activation,of
R6454 T8429 T8432 arg1Of activation,in
R6455 T8431 T8430 arg2Of STAT3,of
R6456 T8434 T8432 arg2Of cells,in
R6457 T8434 T8433 arg1Of cells,myeloma
R6458 T8436 T8435 arg2Of 9,[
R6459 T8437 T8435 arg3Of ],[
R6460 T8440 T8441 arg1Of phosphorylation,of
R6461 T8440 T8443 arg1Of phosphorylation,was
R6462 T8440 T8445 arg2Of phosphorylation,investigated
R6463 T8442 T8441 arg2Of R-Smad,of
R6464 T8445 T8438 arg1Of investigated,However
R6465 T8445 T8439 arg1Of investigated,","
R6466 T8445 T8443 arg2Of investigated,was
R6467 T8445 T8444 arg1Of investigated,not
R6468 T8445 T8446 arg1Of investigated,in
R6469 T8448 T8446 arg2Of study,in
R6470 T8448 T8447 arg1Of study,that
R6471 T8449 T8450 arg1Of BMP-2,has
R6472 T8449 T8452 arg1Of BMP-2,been
R6473 T8449 T8453 arg2Of BMP-2,shown
R6474 T8449 T8455 arg1Of BMP-2,induce
R6475 T8453 T8450 arg2Of shown,has
R6476 T8453 T8451 arg1Of shown,also
R6477 T8453 T8452 arg2Of shown,been
R6478 T8455 T8453 arg3Of induce,shown
R6479 T8455 T8454 arg1Of induce,to
R6480 T8455 T8459 arg1Of induce,[
R6481 T8456 T8455 arg2Of phosphorylation,induce
R6482 T8456 T8457 arg1Of phosphorylation,of
R6483 T8458 T8457 arg2Of p38,of
R6484 T8460 T8459 arg2Of 29,[
R6485 T8461 T8459 arg3Of ],[
R6486 T8464 T8465 arg1Of phosphorylation,of
R6487 T8464 T8471 arg1Of phosphorylation,represent
R6488 T8466 T8467 arg1Of p38,","
R6489 T8467 T8469 arg1Of ",",and
R6490 T8468 T8467 arg2Of STAT3,","
R6491 T8469 T8465 arg2Of and,of
R6492 T8470 T8469 arg2Of Smad1/5/8,and
R6493 T8471 T8462 arg1Of represent,Thus
R6494 T8471 T8463 arg1Of represent,","
R6495 T8474 T8471 arg2Of pathways,represent
R6496 T8474 T8472 arg1Of pathways,important
R6497 T8474 T8473 arg1Of pathways,BMP-signalling
R6498 T8474 T8475 arg1Of pathways,that
R6499 T8474 T8476 arg1Of pathways,mediated
R6500 T8474 T8487 arg1Of pathways,has
R6501 T8474 T8488 arg1Of pathways,been
R6502 T8474 T8489 arg2Of pathways,reported
R6503 T8476 T8481 arg1Of mediated,and
R6504 T8478 T8476 arg2Of effects,mediated
R6505 T8478 T8477 arg1Of effects,the
R6506 T8478 T8479 arg1Of effects,of
R6507 T8480 T8479 arg2Of BMPs,of
R6508 T8482 T8483 arg1Of even,cross-talk
R6509 T8483 T8484 arg1Of cross-talk,between
R6510 T8486 T8484 arg2Of pathways,between
R6511 T8486 T8485 arg1Of pathways,these
R6512 T8489 T8481 arg2Of reported,and
R6513 T8489 T8482 arg1Of reported,even
R6514 T8489 T8487 arg2Of reported,has
R6515 T8489 T8488 arg2Of reported,been
R6516 T8489 T8490 arg1Of reported,[
R6517 T8491 T8490 arg2Of "29,30",[
R6518 T8492 T8490 arg3Of ],[
R6519 T8496 T8493 arg2Of study,In
R6520 T8496 T8494 arg1Of study,the
R6521 T8496 T8495 arg1Of study,present
R6522 T8498 T8499 arg1Of we,were
R6523 T8498 T8501 arg1Of we,able
R6524 T8498 T8503 arg1Of we,detect
R6525 T8499 T8493 arg1Of were,In
R6526 T8499 T8497 arg1Of were,","
R6527 T8499 T8500 arg1Of were,not
R6528 T8501 T8499 arg2Of able,were
R6529 T8503 T8501 arg2Of detect,able
R6530 T8503 T8502 arg1Of detect,to
R6531 T8505 T8503 arg2Of changes,detect
R6532 T8505 T8504 arg1Of changes,BMP-6-induced
R6533 T8505 T8506 arg1Of changes,in
R6534 T8509 T8506 arg2Of status,in
R6535 T8509 T8507 arg1Of status,the
R6536 T8509 T8508 arg1Of status,phosphorylation
R6537 T8509 T8510 arg1Of status,of
R6538 T8509 T8514 arg1Of status,in
R6539 T8511 T8512 arg1Of STAT3,or
R6540 T8512 T8510 arg2Of or,of
R6541 T8513 T8512 arg2Of p38,or
R6542 T8518 T8514 arg2Of cells,in
R6543 T8518 T8515 arg1Of cells,human
R6544 T8518 T8516 arg1Of cells,peripheral
R6545 T8518 T8517 arg1Of cells,B
R6546 T8522 T8523 arg1Of rapid,and
R6547 T8524 T8523 arg2Of marked,and
R6548 T8525 T8521 arg1Of phosphorylation,a
R6549 T8525 T8522 arg1Of phosphorylation,rapid
R6550 T8525 T8524 arg1Of phosphorylation,marked
R6551 T8525 T8526 arg1Of phosphorylation,of
R6552 T8525 T8528 arg1Of phosphorylation,was
R6553 T8525 T8529 arg2Of phosphorylation,revealed
R6554 T8527 T8526 arg2Of Smad1/5/8,of
R6555 T8529 T8519 arg1Of revealed,Instead
R6556 T8529 T8520 arg1Of revealed,","
R6557 T8529 T8528 arg2Of revealed,was
R6558 T8533 T8530 arg2Of study,In
R6559 T8533 T8531 arg1Of study,a
R6560 T8533 T8532 arg1Of study,parallel
R6561 T8535 T8536 arg1Of we,have
R6562 T8535 T8537 arg1Of we,found
R6563 T8537 T8530 arg1Of found,In
R6564 T8537 T8534 arg1Of found,","
R6565 T8537 T8536 arg2Of found,have
R6566 T8540 T8539 arg1Of BMPs,other
R6567 T8540 T8542 arg1Of BMPs,induced
R6568 T8542 T8537 arg2Of induced,found
R6569 T8542 T8538 arg1Of induced,that
R6570 T8542 T8541 arg1Of induced,also
R6571 T8542 T8546 arg1Of induced,in
R6572 T8543 T8542 arg2Of phosphorylation,induced
R6573 T8543 T8544 arg1Of phosphorylation,of
R6574 T8545 T8544 arg2Of Smad1/5/8,of
R6575 T8549 T8546 arg2Of cells,in
R6576 T8549 T8547 arg1Of cells,peripheral
R6577 T8549 T8548 arg1Of cells,B
R6578 T8549 T8550 arg1Of cells,(
R6579 T8551 T8550 arg2Of data,(
R6580 T8551 T8553 arg2Of data,shown
R6581 T8553 T8552 arg1Of shown,not
R6582 T8554 T8550 arg3Of ),(
R6583 T8555 T8556 arg1Of We,are
R6584 T8555 T8558 arg1Of We,pursuing
R6585 T8555 T8562 arg1Of We,identify
R6586 T8558 T8556 arg2Of pursuing,are
R6587 T8558 T8557 arg1Of pursuing,currently
R6588 T8558 T8561 modOf pursuing,to
R6589 T8560 T8558 arg2Of studies,pursuing
R6590 T8560 T8559 arg1Of studies,microarray
R6591 T8562 T8561 arg1Of identify,to
R6592 T8565 T8564 arg1Of pathways,signalling
R6593 T8565 T8566 arg1Of pathways,and
R6594 T8566 T8562 arg2Of and,identify
R6595 T8566 T8563 arg1Of and,the
R6596 T8566 T8569 arg1Of and,that
R6597 T8566 T8570 arg1Of and,are
R6598 T8566 T8572 arg2Of and,regulated
R6599 T8568 T8566 arg2Of genes,and
R6600 T8568 T8567 arg1Of genes,target
R6601 T8572 T8570 arg2Of regulated,are
R6602 T8572 T8571 arg1Of regulated,differently
R6603 T8576 T8572 arg1Of BMPs,regulated
R6604 T8576 T8573 arg2Of BMPs,by
R6605 T8576 T8574 arg1Of BMPs,the
R6606 T8576 T8575 arg1Of BMPs,various
R6607 T8576 T8577 arg1Of BMPs,in
R6608 T8580 T8577 arg2Of cells,in
R6609 T8580 T8578 arg1Of cells,human
R6610 T8580 T8579 arg1Of cells,B
R6611 T8581 T8582 arg1Of Upregulation,of
R6612 T8581 T8584 arg1Of Upregulation,via
R6613 T8581 T8587 arg1Of Upregulation,is
R6614 T8583 T8582 arg2Of Id1,of
R6615 T8586 T8584 arg2Of phosphorylation,via
R6616 T8586 T8585 arg1Of phosphorylation,Smad1/5/8
R6617 T8587 T8601 arg1Of is,and
R6618 T8590 T8587 arg2Of mechanism,is
R6619 T8590 T8588 arg1Of mechanism,a
R6620 T8590 T8589 arg1Of mechanism,known
R6621 T8590 T8591 arg1Of mechanism,for
R6622 T8593 T8591 arg2Of signalling,for
R6623 T8593 T8592 arg1Of signalling,BMP-6
R6624 T8593 T8594 arg1Of signalling,in
R6625 T8597 T8594 arg2Of systems,in
R6626 T8597 T8595 arg1Of systems,other
R6627 T8597 T8596 arg1Of systems,cell
R6628 T8597 T8598 arg1Of systems,[
R6629 T8599 T8598 arg2Of "31,32",[
R6630 T8600 T8598 arg3Of ],[
R6631 T8602 T8603 arg1Of regulation,of
R6632 T8602 T8605 arg1Of regulation,is
R6633 T8602 T8606 arg2Of regulation,thought
R6634 T8602 T8608 arg1Of regulation,be
R6635 T8604 T8603 arg2Of Id-proteins,of
R6636 T8606 T8601 arg2Of thought,and
R6637 T8606 T8605 arg2Of thought,is
R6638 T8608 T8606 arg3Of be,thought
R6639 T8608 T8607 arg1Of be,to
R6640 T8608 T8614 arg1Of be,[
R6641 T8611 T8608 arg2Of mechanism,be
R6642 T8611 T8609 arg1Of mechanism,an
R6643 T8611 T8610 arg1Of mechanism,important
R6644 T8611 T8612 arg1Of mechanism,for
R6645 T8613 T8612 arg2Of Smad-signalling,for
R6646 T8615 T8614 arg2Of 17,[
R6647 T8616 T8614 arg3Of ],[
R6648 T8620 T8617 arg2Of study,In
R6649 T8620 T8618 arg1Of study,the
R6650 T8620 T8619 arg1Of study,present
R6651 T8624 T8622 arg1Of experiments,real-time
R6652 T8624 T8623 arg1Of experiments,RT-PCR
R6653 T8624 T8625 arg1Of experiments,revealed
R6654 T8625 T8617 arg1Of revealed,In
R6655 T8625 T8621 arg1Of revealed,","
R6656 T8625 T8632 arg1Of revealed,in
R6657 T8625 T8636 arg1Of revealed,","
R6658 T8625 T8637 arg1Of revealed,while
R6659 T8629 T8625 arg2Of upregulation,revealed
R6660 T8629 T8626 arg1Of upregulation,a
R6661 T8629 T8627 arg1Of upregulation,specific
R6662 T8629 T8628 arg1Of upregulation,four-fold
R6663 T8629 T8630 arg1Of upregulation,for
R6664 T8631 T8630 arg2Of Id1,for
R6665 T8635 T8632 arg2Of cells,in
R6666 T8635 T8633 arg1Of cells,BMP-6-treated
R6667 T8635 T8634 arg1Of cells,B
R6668 T8639 T8638 arg1Of amount,the
R6669 T8639 T8640 arg1Of amount,of
R6670 T8639 T8642 arg1Of amount,remained
R6671 T8639 T8643 arg1Of amount,unchanged
R6672 T8641 T8640 arg2Of Id2–Id4,of
R6673 T8642 T8637 arg2Of remained,while
R6674 T8643 T8642 arg2Of unchanged,remained
R6675 T8644 T8646 arg1Of In,with
R6676 T8645 T8644 arg2Of agreement,In
R6677 T8647 T8644 arg3Of this,In
R6678 T8651 T8649 arg1Of analysis,western
R6679 T8651 T8650 arg1Of analysis,blot
R6680 T8651 T8652 arg1Of analysis,demonstrated
R6681 T8652 T8644 arg1Of demonstrated,In
R6682 T8652 T8648 arg1Of demonstrated,","
R6683 T8652 T8658 arg1Of demonstrated,","
R6684 T8652 T8659 arg1Of demonstrated,while
R6685 T8654 T8652 arg2Of upregulation,demonstrated
R6686 T8654 T8653 arg1Of upregulation,an
R6687 T8654 T8655 arg1Of upregulation,of
R6688 T8657 T8655 arg2Of protein,of
R6689 T8657 T8656 arg1Of protein,Id1
R6690 T8661 T8660 arg1Of amount,the
R6691 T8661 T8662 arg1Of amount,of
R6692 T8661 T8668 arg1Of amount,remained
R6693 T8661 T8669 arg1Of amount,unchanged
R6694 T8663 T8664 arg1Of Id2,and
R6695 T8665 T8664 arg2Of Id3,and
R6696 T8667 T8662 arg2Of levels,of
R6697 T8667 T8663 arg1Of levels,Id2
R6698 T8667 T8665 arg1Of levels,Id3
R6699 T8667 T8666 arg1Of levels,protein
R6700 T8668 T8659 arg2Of remained,while
R6701 T8669 T8668 arg2Of unchanged,remained
R6702 T8672 T8673 arg1Of Id1,has
R6703 T8672 T8674 arg1Of Id1,been
R6704 T8672 T8675 arg2Of Id1,considered
R6705 T8672 T8678 arg1Of Id1,be
R6706 T8672 T8679 arg2Of Id1,expressed
R6707 T8675 T8673 arg2Of considered,has
R6708 T8675 T8674 arg2Of considered,been
R6709 T8675 T8691 arg1Of considered,and
R6710 T8679 T8675 arg3Of expressed,considered
R6711 T8679 T8676 arg1Of expressed,not
R6712 T8679 T8677 arg1Of expressed,to
R6713 T8679 T8678 arg2Of expressed,be
R6714 T8679 T8680 arg1Of expressed,in
R6715 T8683 T8680 arg2Of stages,in
R6716 T8683 T8681 arg1Of stages,later
R6717 T8683 T8682 arg1Of stages,developmental
R6718 T8683 T8684 arg1Of stages,than
R6719 T8686 T8684 arg2Of cells,than
R6720 T8686 T8685 arg1Of cells,pro-B
R6721 T8686 T8687 arg1Of cells,[
R6722 T8688 T8687 arg2Of "33,34",[
R6723 T8689 T8687 arg3Of ],[
R6724 T8691 T8670 arg1Of and,Previously
R6725 T8691 T8671 arg1Of and,","
R6726 T8691 T8690 arg1Of and,","
R6727 T8694 T8692 arg1Of expression,its
R6728 T8694 T8693 arg1Of expression,constitutive
R6729 T8694 T8695 arg1Of expression,has
R6730 T8694 T8696 arg1Of expression,been
R6731 T8694 T8697 arg2Of expression,reported
R6732 T8694 T8699 arg1Of expression,impair
R6733 T8697 T8691 arg2Of reported,and
R6734 T8697 T8695 arg2Of reported,has
R6735 T8697 T8696 arg2Of reported,been
R6736 T8699 T8697 arg3Of impair,reported
R6737 T8699 T8698 arg1Of impair,to
R6738 T8699 T8704 arg1Of impair,[
R6739 T8703 T8699 arg2Of development,impair
R6740 T8703 T8700 arg1Of development,mouse
R6741 T8703 T8701 arg1Of development,B
R6742 T8703 T8702 arg1Of development,cell
R6743 T8705 T8704 arg2Of 35,[
R6744 T8706 T8704 arg3Of ],[
R6745 T8710 T8709 arg1Of demonstration,our
R6746 T8710 T8711 arg1Of demonstration,of
R6747 T8710 T8726 arg1Of demonstration,is
R6748 T8710 T8727 arg1Of demonstration,of
R6749 T8714 T8711 arg2Of upregulation,of
R6750 T8714 T8712 arg1Of upregulation,the
R6751 T8714 T8713 arg1Of upregulation,time-dependent
R6752 T8714 T8715 arg1Of upregulation,of
R6753 T8714 T8720 arg1Of upregulation,in
R6754 T8717 T8716 arg1Of mRNA,Id1
R6755 T8717 T8718 arg1Of mRNA,and
R6756 T8718 T8715 arg2Of and,of
R6757 T8719 T8718 arg2Of protein,and
R6758 T8725 T8720 arg2Of cells,in
R6759 T8725 T8721 arg1Of cells,mature
R6760 T8725 T8722 arg1Of cells,normal
R6761 T8725 T8723 arg1Of cells,human
R6762 T8725 T8724 arg1Of cells,B
R6763 T8726 T8707 arg1Of is,Therefore
R6764 T8726 T8708 arg1Of is,","
R6765 T8727 T8726 arg2Of of,is
R6766 T8729 T8727 arg2Of interest,of
R6767 T8729 T8728 arg1Of interest,particular
R6768 T8732 T8730 arg2Of respect,In
R6769 T8732 T8731 arg1Of respect,that
R6770 T8735 T8730 arg1Of is,In
R6771 T8735 T8733 arg1Of is,","
R6772 T8736 T8735 arg2Of noteworthy,is
R6773 T8739 T8738 arg1Of signalling,TGF-β
R6774 T8739 T8740 arg1Of signalling,in
R6775 T8739 T8746 arg1Of signalling,induces
R6776 T8741 T8742 arg1Of early,and
R6777 T8743 T8742 arg2Of mature,and
R6778 T8745 T8740 arg2Of cells,in
R6779 T8745 T8741 arg1Of cells,early
R6780 T8745 T8743 arg1Of cells,mature
R6781 T8745 T8744 arg1Of cells,B
R6782 T8746 T8734 arg1Of induces,it
R6783 T8746 T8735 arg1Of induces,is
R6784 T8746 T8736 arg1Of induces,noteworthy
R6785 T8746 T8737 arg1Of induces,that
R6786 T8748 T8749 arg1Of Id2,and
R6787 T8750 T8749 arg2Of Id3,and
R6788 T8751 T8747 arg1Of expression,both
R6789 T8751 T8748 arg1Of expression,Id2
R6790 T8751 T8750 arg1Of expression,Id3
R6791 T8751 T8752 arg1Of expression,[
R6792 T8751 T8756 arg1Of expression,but
R6793 T8753 T8752 arg2Of "36,37",[
R6794 T8754 T8752 arg3Of ],[
R6795 T8756 T8746 arg2Of but,induces
R6796 T8756 T8755 arg1Of but,","
R6797 T8758 T8756 arg2Of Id1,but
R6798 T8758 T8757 arg1Of Id1,not
R6799 T8758 T8759 arg1Of Id1,(
R6800 T8760 T8759 arg2Of data,(
R6801 T8760 T8762 arg2Of data,shown
R6802 T8762 T8761 arg1Of shown,not
R6803 T8763 T8759 arg3Of ),(
R6804 T8767 T8766 arg1Of results,these
R6805 T8767 T8768 arg1Of results,show
R6806 T8768 T8764 arg1Of show,Interestingly
R6807 T8768 T8765 arg1Of show,","
R6808 T8771 T8770 arg1Of members,various
R6809 T8771 T8772 arg1Of members,of
R6810 T8771 T8776 arg1Of members,regulate
R6811 T8775 T8772 arg2Of family,of
R6812 T8775 T8773 arg1Of family,the
R6813 T8775 T8774 arg1Of family,TGF-β
R6814 T8776 T8768 arg2Of regulate,show
R6815 T8776 T8769 arg1Of regulate,that
R6816 T8776 T8779 arg1Of regulate,differently
R6817 T8778 T8776 arg2Of proteins,regulate
R6818 T8778 T8777 arg1Of proteins,Id
R6819 T8780 T8781 arg1Of Id2,and
R6820 T8781 T8783 arg1Of and,are
R6821 T8781 T8784 arg2Of and,considered
R6822 T8781 T8786 arg1Of and,be
R6823 T8782 T8781 arg2Of Id3,and
R6824 T8784 T8783 arg2Of considered,are
R6825 T8786 T8784 arg3Of be,considered
R6826 T8786 T8785 arg1Of be,to
R6827 T8789 T8786 arg2Of proteins,be
R6828 T8789 T8787 arg1Of proteins,the
R6829 T8789 T8788 arg1Of proteins,Id
R6830 T8789 T8791 arg2Of proteins,expressed
R6831 T8791 T8790 arg1Of expressed,mainly
R6832 T8791 T8792 arg1Of expressed,in
R6833 T8795 T8792 arg2Of cells,in
R6834 T8795 T8793 arg1Of cells,mature
R6835 T8795 T8794 arg1Of cells,B
R6836 T8795 T8796 arg1Of cells,[
R6837 T8797 T8796 arg2Of 38,[
R6838 T8798 T8796 arg3Of ],[
R6839 T8801 T8799 arg1Of study,The
R6840 T8801 T8800 arg1Of study,present
R6841 T8801 T8803 arg1Of study,found
R6842 T8803 T8802 arg1Of found,also
R6843 T8804 T8805 arg1Of Id2,and
R6844 T8805 T8803 arg2Of and,found
R6845 T8805 T8808 arg1Of and,in
R6846 T8805 T8812 arg1Of and,be
R6847 T8805 T8815 arg2Of and,expressed
R6848 T8807 T8805 arg2Of protein,and
R6849 T8807 T8806 arg1Of protein,Id3
R6850 T8810 T8808 arg2Of cells,in
R6851 T8810 T8809 arg1Of cells,B
R6852 T8814 T8813 arg1Of highly,more
R6853 T8815 T8803 arg3Of expressed,found
R6854 T8815 T8811 arg1Of expressed,to
R6855 T8815 T8812 arg2Of expressed,be
R6856 T8815 T8814 arg1Of expressed,highly
R6857 T8815 T8816 arg1Of expressed,than
R6858 T8817 T8816 arg2Of Id1,than
R6859 T8817 T8818 arg1Of Id1,in
R6860 T8821 T8818 arg2Of cells,in
R6861 T8821 T8819 arg1Of cells,resting
R6862 T8821 T8820 arg1Of cells,B
R6863 T8824 T8825 arg1Of BMP-6,did
R6864 T8824 T8827 arg1Of BMP-6,induce
R6865 T8827 T8822 arg1Of induce,However
R6866 T8827 T8823 arg1Of induce,","
R6867 T8827 T8825 arg2Of induce,did
R6868 T8827 T8826 arg1Of induce,not
R6869 T8829 T8827 arg2Of changes,induce
R6870 T8829 T8828 arg1Of changes,significant
R6871 T8829 T8830 arg1Of changes,in
R6872 T8833 T8830 arg2Of expression,in
R6873 T8833 T8831 arg1Of expression,the
R6874 T8833 T8832 arg1Of expression,protein
R6875 T8833 T8834 arg1Of expression,of
R6876 T8835 T8836 arg1Of Id2,and
R6877 T8836 T8834 arg2Of and,of
R6878 T8837 T8836 arg2Of Id3,and
R6879 T8838 T8839 arg1Of It,is
R6880 T8838 T8840 arg2Of It,believed
R6881 T8840 T8839 arg2Of believed,is
R6882 T8843 T8842 arg1Of proteins,Id
R6883 T8843 T8844 arg1Of proteins,block
R6884 T8843 T8847 arg1Of proteins,promote
R6885 T8844 T8846 arg1Of block,and
R6886 T8845 T8844 arg2Of differentiation,block
R6887 T8846 T8840 arg3Of and,believed
R6888 T8846 T8841 arg1Of and,that
R6889 T8846 T8849 arg1Of and,in
R6890 T8847 T8846 arg2Of promote,and
R6891 T8848 T8847 arg2Of proliferation,promote
R6892 T8852 T8849 arg2Of types,in
R6893 T8852 T8850 arg1Of types,various
R6894 T8852 T8851 arg1Of types,cell
R6895 T8852 T8853 arg1Of types,[
R6896 T8854 T8853 arg2Of "39,33",[
R6897 T8855 T8853 arg3Of ],[
R6898 T8857 T8856 arg1Of proteins,Id
R6899 T8857 T8858 arg1Of proteins,act
R6900 T8857 T8868 arg1Of proteins,forming
R6901 T8858 T8859 arg1Of act,as
R6902 T8858 T8867 arg1Of act,by
R6903 T8861 T8860 arg1Of inhibitors,dominant-negative
R6904 T8861 T8862 arg1Of inhibitors,of
R6905 T8861 T8864 arg1Of inhibitors,and
R6906 T8863 T8862 arg2Of E-proteins,of
R6907 T8864 T8859 arg2Of and,as
R6908 T8866 T8864 arg2Of function,and
R6909 T8866 T8865 arg1Of function,Pax5
R6910 T8868 T8867 arg2Of forming,by
R6911 T8868 T8870 arg1Of forming,with
R6912 T8868 T8873 arg1Of forming,","
R6913 T8868 T8874 modOf forming,making
R6914 T8869 T8868 arg2Of dimers,forming
R6915 T8872 T8870 arg2Of proteins,with
R6916 T8872 T8871 arg1Of proteins,these
R6917 T8875 T8874 arg2Of them,making
R6918 T8875 T8876 arg1Of them,unable
R6919 T8875 T8878 arg1Of them,bind
R6920 T8876 T8874 arg3Of unable,making
R6921 T8878 T8876 arg2Of bind,unable
R6922 T8878 T8877 arg1Of bind,to
R6923 T8879 T8878 arg2Of DNA,bind
R6924 T8880 T8881 arg1Of It,has
R6925 T8880 T8882 arg1Of It,been
R6926 T8880 T8883 arg2Of It,proposed
R6927 T8883 T8881 arg2Of proposed,has
R6928 T8883 T8882 arg2Of proposed,been
R6929 T8886 T8885 arg1Of balance,the
R6930 T8886 T8887 arg1Of balance,among
R6931 T8886 T8894 arg1Of balance,might
R6932 T8886 T8895 arg1Of balance,have
R6933 T8888 T8889 arg1Of E-proteins,","
R6934 T8889 T8891 arg1Of ",",and
R6935 T8890 T8889 arg2Of Pax5,","
R6936 T8891 T8887 arg2Of and,among
R6937 T8893 T8891 arg2Of proteins,and
R6938 T8893 T8892 arg1Of proteins,Id
R6939 T8895 T8883 arg3Of have,proposed
R6940 T8895 T8884 arg1Of have,that
R6941 T8895 T8894 arg2Of have,might
R6942 T8895 T8899 arg1Of have,in
R6943 T8898 T8895 arg2Of role,have
R6944 T8898 T8896 arg1Of role,an
R6945 T8898 T8897 arg1Of role,important
R6946 T8902 T8899 arg2Of cells,in
R6947 T8902 T8900 arg2Of cells,activated
R6948 T8902 T8901 arg1Of cells,B
R6949 T8902 T8903 arg1Of cells,[
R6950 T8904 T8903 arg2Of 38,[
R6951 T8905 T8903 arg3Of ],[
R6952 T8908 T8906 arg2Of respect,In
R6953 T8908 T8907 arg1Of respect,that
R6954 T8910 T8911 arg1Of E-proteins,have
R6955 T8910 T8912 arg1Of E-proteins,been
R6956 T8910 T8913 arg2Of E-proteins,implicated
R6957 T8913 T8906 arg1Of implicated,In
R6958 T8913 T8909 arg1Of implicated,","
R6959 T8913 T8911 arg2Of implicated,have
R6960 T8913 T8912 arg2Of implicated,been
R6961 T8913 T8914 arg1Of implicated,in
R6962 T8913 T8925 arg1Of implicated,at
R6963 T8917 T8918 arg1Of promotion,and
R6964 T8918 T8914 arg2Of and,in
R6965 T8918 T8915 arg1Of and,both
R6966 T8918 T8916 arg1Of and,the
R6967 T8918 T8920 arg1Of and,of
R6968 T8919 T8918 arg2Of inhibition,and
R6969 T8922 T8923 arg1Of survival,and
R6970 T8923 T8920 arg2Of and,of
R6971 T8923 T8921 arg1Of and,cell
R6972 T8924 T8923 arg2Of growth,and
R6973 T8927 T8925 arg2Of points,at
R6974 T8927 T8926 arg1Of points,different
R6975 T8927 T8928 arg1Of points,in
R6976 T8930 T8928 arg2Of development,in
R6977 T8930 T8929 arg1Of development,lymphocyte
R6978 T8930 T8931 arg1Of development,[
R6979 T8932 T8931 arg2Of 40,[
R6980 T8933 T8931 arg3Of ],[
R6981 T8937 T8934 arg1Of death,The
R6982 T8937 T8935 arg1Of death,antiproliferative
R6983 T8937 T8936 arg1Of death,and
R6984 T8937 T8938 arg1Of death,inducing
R6985 T8937 T8951 arg1Of death,is
R6986 T8937 T8953 arg1Of death,in
R6987 T8939 T8938 arg2Of effect,inducing
R6988 T8939 T8940 arg1Of effect,of
R6989 T8939 T8942 arg1Of effect,in
R6990 T8939 T8945 arg1Of effect,with
R6991 T8941 T8940 arg2Of BMP-6,of
R6992 T8944 T8942 arg2Of cells,in
R6993 T8944 T8943 arg1Of cells,B
R6994 T8947 T8945 arg2Of upregulation,with
R6995 T8947 T8946 arg1Of upregulation,concomitant
R6996 T8947 T8948 arg1Of upregulation,of
R6997 T8950 T8948 arg2Of protein,of
R6998 T8950 T8949 arg1Of protein,Id1
R6999 T8951 T8952 arg1Of is,therefore
R7000 T8953 T8951 arg2Of in,is
R7001 T8954 T8953 arg2Of line,in
R7002 T8954 T8955 arg1Of line,with
R7003 T8957 T8955 arg2Of view,with
R7004 T8957 T8956 arg1Of view,the
R7005 T8960 T8959 arg1Of proteins,Id
R7006 T8960 T8961 arg1Of proteins,are
R7007 T8960 T8962 arg2Of proteins,required
R7008 T8962 T8957 arg2Of required,view
R7009 T8962 T8958 arg1Of required,that
R7010 T8962 T8961 arg2Of required,are
R7011 T8962 T8963 arg1Of required,for
R7012 T8962 T8976 arg1Of required,[
R7013 T8965 T8963 arg2Of induction,for
R7014 T8965 T8964 arg1Of induction,the
R7015 T8965 T8966 arg1Of induction,of
R7016 T8965 T8971 arg1Of induction,in
R7017 T8965 T8974 arg1Of induction,by
R7018 T8968 T8967 arg1Of arrest,growth
R7019 T8968 T8969 arg1Of arrest,and
R7020 T8969 T8966 arg2Of and,of
R7021 T8970 T8969 arg2Of apoptosis,and
R7022 T8973 T8971 arg2Of progenitors,in
R7023 T8973 T8972 arg1Of progenitors,B-lymphocyte
R7024 T8975 T8974 arg2Of TGF-β,by
R7025 T8977 T8976 arg2Of 40,[
R7026 T8978 T8976 arg3Of ],[
R7027 T8982 T8981 arg1Of proteins,Id
R7028 T8982 T8983 arg1Of proteins,are
R7029 T8982 T8984 arg2Of proteins,known
R7030 T8984 T8979 arg1Of known,Furthermore
R7031 T8984 T8980 arg1Of known,","
R7032 T8984 T8983 arg2Of known,are
R7033 T8984 T8985 arg1Of known,as
R7034 T8987 T8985 arg2Of parts,as
R7035 T8996 T8994 arg2Of cycle,","
R7036 T8996 T8995 arg1Of cycle,cell
R7037 T8997 T8992 arg2Of and,in
R7038 T8998 T8997 arg2Of tumorigenesis,and
R7039 T8998 T8999 arg1Of tumorigenesis,[
R7040 T8987 T8986 arg1Of parts,important
R7041 T8987 T8988 arg1Of parts,of
R7042 T9000 T8999 arg2Of 32,[
R7043 T8990 T8988 arg2Of pathways,of
R7044 T9001 T8999 arg3Of ],[
R7045 T9002 T9003 arg1Of It,is
R7046 T9002 T9005 arg2Of It,established
R7047 T9005 T9003 arg2Of established,is
R7048 T9005 T9004 arg1Of established,well
R7049 T8990 T8989 arg1Of pathways,signalling
R7050 T8990 T8991 arg2Of pathways,involved
R7051 T9008 T9007 arg1Of members,various
R7052 T9008 T9009 arg1Of members,of
R7053 T9008 T9013 arg1Of members,are
R7054 T9008 T9014 arg2Of members,overexpressed
R7055 T8991 T8992 arg1Of involved,in
R7056 T8993 T8994 arg1Of development,","
R7057 T9012 T9009 arg2Of family,of
R7058 T9012 T9010 arg1Of family,the
R7059 T9012 T9011 arg1Of family,Id
R7060 T9014 T9005 arg3Of overexpressed,established
R7061 T9014 T9006 arg1Of overexpressed,that
R7062 T9014 T9013 arg2Of overexpressed,are
R7063 T9014 T9015 arg1Of overexpressed,in
R7064 T9014 T9022 arg1Of overexpressed,generally
R7065 T9015 T9021 arg1Of in,and
R7066 T9017 T9015 arg2Of range,in
R7067 T9017 T9016 arg1Of range,a
R7068 T9017 T9018 arg1Of range,of
R7069 T9020 T9018 arg2Of tumours,of
R7070 T8994 T8997 arg1Of ",",and
R7071 T9020 T9019 arg1Of tumours,human
R7072 T9022 T9021 arg2Of generally,and
R7073 T9024 T9025 arg1Of Id1,appears
R7074 T9024 T9027 arg1Of Id1,be
R7075 T9093 T9091 arg2Of respect,In
R7076 T9025 T9003 modOf appears,is
R7077 T9025 T9023 arg1Of appears,","
R7078 T9027 T9025 arg2Of be,appears
R7079 T9027 T9026 arg1Of be,to
R7080 T9030 T9027 arg2Of member,be
R7081 T9030 T9028 arg1Of member,the
R7082 T9030 T9029 arg1Of member,family
R7083 T9030 T9033 arg2Of member,overexpressed
R7084 T9032 T9031 arg1Of widely,most
R7085 T9093 T9092 arg1Of respect,this
R7086 T9033 T9032 arg1Of overexpressed,widely
R7087 T9033 T9034 arg1Of overexpressed,in
R7088 T9095 T9096 arg1Of it,is
R7089 T9095 T9106 arg1Of it,resulted
R7090 T9098 T9097 arg2Of interest,of
R7091 T9036 T9034 arg2Of variety,in
R7092 T9036 T9035 arg1Of variety,a
R7093 T9036 T9037 arg1Of variety,of
R7094 T9039 T9037 arg2Of malignancies,of
R7095 T9039 T9038 arg1Of malignancies,human
R7096 T9039 T9040 arg1Of malignancies,[
R7097 T9039 T9043 arg1Of malignancies,","
R7098 T9039 T9044 arg1Of malignancies,including
R7099 T9098 T9099 arg1Of interest,that
R7100 T9041 T9040 arg2Of 41,[
R7101 T9042 T9040 arg3Of ],[
R7102 T9098 T9100 arg1Of interest,targeted
R7103 T9101 T9100 arg2Of expression,targeted
R7104 T9046 T9044 arg2Of myeloma,including
R7105 T9046 T9045 arg1Of myeloma,multiple
R7106 T9046 T9047 arg1Of myeloma,[
R7107 T9048 T9047 arg2Of "42,32",[
R7108 T9049 T9047 arg3Of ],[
R7109 T9101 T9102 arg1Of expression,of
R7110 T9053 T9052 arg1Of findings,our
R7111 T9053 T9064 arg1Of findings,might
R7112 T9053 T9065 arg1Of findings,be
R7113 T9053 T9066 arg1Of findings,of
R7114 T9103 T9102 arg2Of Id1,of
R7115 T9055 T9056 arg1Of BMP-6,activates
R7116 T9056 T9053 arg2Of activates,findings
R7117 T9056 T9054 arg1Of activates,that
R7118 T9103 T9104 arg1Of Id1,to
R7119 T9059 T9056 arg2Of pathways,activates
R7120 T9059 T9057 arg1Of pathways,intracellular
R7121 T9059 T9058 arg1Of pathways,signalling
R7122 T9059 T9060 arg1Of pathways,in
R7123 T9105 T9104 arg2Of B-lymphocytes,to
R7124 T9063 T9060 arg2Of cells,in
R7125 T9063 T9061 arg1Of cells,human
R7126 T9063 T9062 arg1Of cells,B
R7127 T9106 T9091 arg1Of resulted,In
R7128 T9065 T9050 arg1Of be,Additionally
R7129 T9065 T9051 arg1Of be,","
R7130 T9065 T9064 arg2Of be,might
R7131 T9065 T9070 arg1Of be,in
R7132 T9066 T9065 arg2Of of,be
R7133 T9106 T9094 arg1Of resulted,","
R7134 T9106 T9096 arg2Of resulted,is
R7135 T9106 T9097 arg1Of resulted,of
R7136 T9106 T9107 arg1Of resulted,in
R7137 T9069 T9066 arg2Of significance,of
R7138 T9069 T9067 arg1Of significance,potential
R7139 T9069 T9068 arg1Of significance,pathophysiological
R7140 T9106 T9123 arg1Of resulted,[
R7141 T9111 T9108 arg1Of development,aberrant
R7142 T9071 T9072 arg1Of lymphoma,and
R7143 T9072 T9070 arg2Of and,in
R7144 T9073 T9072 arg2Of inflammation,and
R7145 T9077 T9074 arg1Of expression,High
R7146 T9077 T9075 arg1Of expression,BMP-6
R7147 T9077 T9076 arg1Of expression,mRNA
R7148 T9077 T9078 arg1Of expression,in
R7149 T9077 T9080 arg1Of expression,has
R7150 T9077 T9081 arg1Of expression,been
R7151 T9077 T9082 arg2Of expression,shown
R7152 T9077 T9084 arg1Of expression,correlate
R7153 T9079 T9078 arg2Of DLBCL,in
R7154 T9111 T9109 arg1Of development,B
R7155 T9111 T9110 arg1Of development,cell
R7156 T9082 T9080 arg2Of shown,has
R7157 T9082 T9081 arg2Of shown,been
R7158 T9084 T9082 arg3Of correlate,shown
R7159 T9084 T9083 arg1Of correlate,to
R7160 T9084 T9085 arg1Of correlate,to
R7161 T9111 T9112 arg1Of development,","
R7162 T9087 T9085 arg2Of outcome,to
R7163 T9087 T9086 arg1Of outcome,unfavourable
R7164 T9087 T9088 arg1Of outcome,[
R7165 T9112 T9116 arg1Of ",",and
R7166 T9089 T9088 arg2Of 12,[
R7167 T9114 T9112 arg2Of apoptosis,","
R7168 T9090 T9088 arg3Of ],[
R7169 T9114 T9113 arg1Of apoptosis,massive
R7170 T9116 T9107 arg2Of and,in
R7171 T9116 T9115 arg1Of and,","
R7172 T9118 T9116 arg2Of development,and
R7173 T9189 T9188 arg1Of cells,B
R7174 T9189 T9190 arg1Of cells,are
R7175 T9189 T9191 arg2Of cells,involved
R7176 T9118 T9117 arg1Of development,subsequent
R7177 T9191 T9187 arg2Of involved,where
R7178 T9191 T9190 arg2Of involved,are
R7179 T9118 T9119 arg1Of development,of
R7180 T9192 T9193 arg1Of It,will
R7181 T9192 T9195 arg1Of It,be
R7182 T9192 T9196 arg1Of It,important
R7183 T9122 T9119 arg2Of lymphomas,of
R7184 T9195 T9193 arg2Of be,will
R7185 T9195 T9194 arg1Of be,therefore
R7186 T9195 T9197 modOf be,to
R7187 T9196 T9195 arg2Of important,be
R7188 T9199 T9197 arg1Of elucidate,to
R7189 T9199 T9198 arg1Of elucidate,further
R7190 T9122 T9120 arg1Of lymphomas,B
R7191 T9201 T9199 arg2Of role,elucidate
R7192 T9201 T9200 arg1Of role,the
R7193 T9201 T9202 arg1Of role,of
R7194 T9201 T9204 arg1Of role,in
R7195 T9201 T9208 arg1Of role,by
R7196 T9122 T9121 arg1Of lymphomas,cell
R7197 T9203 T9202 arg2Of Id-1,of
R7198 T9124 T9123 arg2Of 35,[
R7199 T9207 T9204 arg2Of cells,in
R7200 T9207 T9205 arg1Of cells,human
R7201 T9207 T9206 arg1Of cells,B
R7202 T9125 T9123 arg3Of ],[
R7203 T9209 T9208 arg2Of selective,by
R7204 T9209 T9210 arg1Of selective,over
R7205 T9128 T9129 arg1Of BMP-6,has
R7206 T9211 T9212 arg1Of expression,or
R7207 T9212 T9210 arg2Of or,over
R7208 T9213 T9212 arg2Of inhibition,or
R7209 T9217 T9208 arg3Of expression,by
R7210 T9217 T9214 arg1Of expression,of
R7211 T9217 T9215 arg1Of expression,Id-1
R7212 T9217 T9216 arg1Of expression,gene
R7213 T9128 T9130 arg1Of BMP-6,been
R7214 T9220 T9218 arg2Of role,Given
R7215 T9220 T9219 arg1Of role,the
R7216 T9220 T9221 arg1Of role,of
R7217 T9220 T9223 arg1Of role,in
R7218 T9220 T9228 arg1Of role,demonstrated
R7219 T9128 T9131 arg2Of BMP-6,suggested
R7220 T9222 T9221 arg2Of BMP-6,of
R7221 T9128 T9133 arg1Of BMP-6,play
R7222 T9131 T9129 arg2Of suggested,has
R7223 T9227 T9223 arg2Of cells,in
R7224 T9227 T9224 arg1Of cells,mature
R7225 T9227 T9225 arg1Of cells,human
R7226 T9227 T9226 arg1Of cells,B
R7227 T9228 T9218 modOf demonstrated,Given
R7228 T9229 T9228 arg2Of here,demonstrated
R7229 T9229 T9249 arg2Of here,contribute
R7230 T9131 T9130 arg2Of suggested,been
R7231 T9231 T9232 arg1Of identification,of
R7232 T9231 T9242 arg1Of identification,with
R7233 T9231 T9248 arg1Of identification,might
R7234 T9231 T9249 arg1Of identification,contribute
R7235 T9131 T9142 arg1Of suggested,[
R7236 T9233 T9234 arg1Of BMP-6,producing
R7237 T9131 T9145 arg1Of suggested,and
R7238 T9234 T9237 arg1Of producing,vivo
R7239 T9234 T9238 arg1Of producing,with
R7240 T9235 T9234 arg2Of cells,producing
R7241 T9133 T9131 arg3Of play,suggested
R7242 T9237 T9236 arg1Of vivo,in
R7243 T9133 T9132 arg1Of play,to
R7244 T9239 T9238 arg2Of possibility,with
R7245 T9133 T9136 arg1Of play,in
R7246 T9135 T9133 arg2Of role,play
R7247 T9241 T9232 arg2Of interaction,of
R7248 T9241 T9233 arg1Of interaction,BMP-6
R7249 T9241 T9240 arg1Of interaction,of
R7250 T9243 T9244 arg1Of naïve,and
R7251 T9244 T9242 arg2Of and,with
R7252 T9135 T9134 arg1Of role,a
R7253 T9138 T9136 arg2Of arthritis,in
R7254 T9247 T9244 arg2Of cells,and
R7255 T9247 T9245 arg1Of cells,memory
R7256 T9247 T9246 arg1Of cells,B
R7257 T9249 T9230 arg1Of contribute,","
R7258 T9249 T9248 arg2Of contribute,might
R7259 T9249 T9250 arg1Of contribute,to
R7260 T9138 T9137 arg1Of arthritis,rheumatoid
R7261 T9138 T9139 arg1Of arthritis,(
R7262 T9140 T9139 arg2Of RA,(
R7263 T9252 T9250 arg2Of understanding,to
R7264 T9252 T9251 arg1Of understanding,the
R7265 T9252 T9253 arg1Of understanding,of
R7266 T9141 T9139 arg3Of ),(
R7267 T9257 T9253 arg2Of biology,of
R7268 T9257 T9254 arg1Of biology,mature
R7269 T9257 T9255 arg1Of biology,B
R7270 T9257 T9256 arg1Of biology,cell
R7271 T9143 T9142 arg2Of "43,44",[
R7272 T9261 T9258 arg1Of expression,High
R7273 T9261 T9259 arg1Of expression,BMP-6
R7274 T9261 T9260 arg1Of expression,mRNA
R7275 T9261 T9262 arg1Of expression,in
R7276 T9261 T9264 arg1Of expression,has
R7277 T9261 T9265 arg1Of expression,been
R7278 T9261 T9266 arg2Of expression,detected
R7279 T9144 T9142 arg3Of ],[
R7280 T9263 T9262 arg2Of DLBCL,in
R7281 T9145 T9126 arg1Of and,Moreover
R7282 T9266 T9264 arg2Of detected,has
R7283 T9266 T9265 arg2Of detected,been
R7284 T9266 T9271 arg1Of detected,[
R7285 T9145 T9127 arg1Of and,","
R7286 T9147 T9146 arg1Of levels,elevated
R7287 T9270 T9266 arg1Of profiling,detected
R7288 T9270 T9267 arg2Of profiling,by
R7289 T9270 T9268 arg1Of profiling,gene
R7290 T9270 T9269 arg1Of profiling,expression
R7291 T9272 T9271 arg2Of 12,[
R7292 T9273 T9271 arg3Of ],[
R7293 T9147 T9148 arg1Of levels,of
R7294 T9147 T9152 arg1Of levels,have
R7295 T9276 T9277 arg1Of production,of
R7296 T9276 T9280 arg1Of production,in
R7297 T9276 T9285 arg1Of production,was
R7298 T9276 T9286 arg2Of production,detected
R7299 T9147 T9153 arg1Of levels,been
R7300 T9279 T9277 arg2Of transcripts,of
R7301 T9279 T9278 arg1Of transcripts,BMP-6
R7302 T9147 T9154 arg2Of levels,found
R7303 T9149 T9150 arg1Of Id1,and
R7304 T9284 T9280 arg2Of cells,in
R7305 T9284 T9281 arg1Of cells,normal
R7306 T9284 T9282 arg2Of cells,activated
R7307 T9284 T9283 arg1Of cells,B
R7308 T9150 T9148 arg2Of and,of
R7309 T9151 T9150 arg2Of Id3,and
R7310 T9154 T9145 arg2Of found,and
R7311 T9286 T9274 arg1Of detected,Furthermore
R7312 T9286 T9275 arg1Of detected,","
R7313 T9286 T9285 arg2Of detected,was
R7314 T9286 T9287 arg1Of detected,in
R7315 T9154 T9152 arg2Of found,have
R7316 T9290 T9287 arg2Of study,in
R7317 T9290 T9288 arg1Of study,the
R7318 T9290 T9289 arg1Of study,same
R7319 T9154 T9153 arg2Of found,been
R7320 T9292 T9291 arg2Of note,Of
R7321 T9154 T9155 arg1Of found,in
R7322 T9157 T9155 arg2Of synovia,in
R7323 T9297 T9294 arg1Of loop,an
R7324 T9297 T9295 arg1Of loop,autocrine
R7325 T9297 T9296 arg1Of loop,BMP-6
R7326 T9297 T9298 arg1Of loop,has
R7327 T9297 T9299 arg1Of loop,been
R7328 T9297 T9300 arg2Of loop,reported
R7329 T9157 T9156 arg1Of synovia,the
R7330 T9300 T9291 arg1Of reported,Of
R7331 T9300 T9293 arg1Of reported,","
R7332 T9300 T9298 arg2Of reported,has
R7333 T9300 T9299 arg2Of reported,been
R7334 T9300 T9301 arg1Of reported,by
R7335 T9300 T9306 arg1Of reported,in
R7336 T9300 T9309 arg1Of reported,[
R7337 T9301 T9305 arg1Of by,and
R7338 T9302 T9301 arg2Of others,by
R7339 T9302 T9303 arg1Of others,in
R7340 T9157 T9158 arg1Of synovia,of
R7341 T9304 T9303 arg2Of chondrocytes,in
R7342 T9157 T9160 arg1Of synovia,[
R7343 T9159 T9158 arg2Of RA-patients,of
R7344 T9306 T9305 arg2Of in,and
R7345 T9308 T9306 arg2Of ovarium,in
R7346 T9308 T9307 arg1Of ovarium,the
R7347 T9161 T9160 arg2Of 45,[
R7348 T9310 T9309 arg2Of "46,19,18",[
R7349 T9311 T9309 arg3Of ],[
R7350 T9162 T9160 arg3Of ],[
R7351 T9314 T9315 arg1Of we,wanted
R7352 T9314 T9317 arg1Of we,explore
R7353 T9315 T9312 arg1Of wanted,Therefore
R7354 T9315 T9313 arg1Of wanted,","
R7355 T9166 T9165 arg1Of results,these
R7356 T9317 T9315 arg2Of explore,wanted
R7357 T9317 T9316 arg1Of explore,to
R7358 T9317 T9320 arg1Of explore,for
R7359 T9319 T9317 arg2Of possibility,explore
R7360 T9319 T9318 arg1Of possibility,the
R7361 T9324 T9320 arg2Of loop,for
R7362 T9166 T9167 arg1Of results,point
R7363 T9167 T9163 arg1Of point,Altogether
R7364 T9324 T9321 arg1Of loop,an
R7365 T9324 T9322 arg1Of loop,autocrine
R7366 T9324 T9323 arg1Of loop,BMP-6
R7367 T9324 T9325 arg1Of loop,in
R7368 T9167 T9164 arg1Of point,","
R7369 T9167 T9168 arg1Of point,to
R7370 T9171 T9168 arg2Of role,to
R7371 T9328 T9325 arg2Of cells,in
R7372 T9328 T9326 arg1Of cells,human
R7373 T9328 T9327 arg1Of cells,B
R7374 T9329 T9330 arg1Of We,analysed
R7375 T9330 T9340 arg1Of analysed,by
R7376 T9330 T9364 arg1Of analysed,","
R7377 T9330 T9365 arg1Of analysed,anti-IgM
R7378 T9171 T9169 arg1Of role,an
R7379 T9334 T9330 arg2Of mRNA,analysed
R7380 T9334 T9331 arg1Of mRNA,the
R7381 T9334 T9332 arg1Of mRNA,expression
R7382 T9334 T9333 arg1Of mRNA,BMP-6
R7383 T9334 T9335 arg1Of mRNA,in
R7384 T9171 T9170 arg1Of role,important
R7385 T9171 T9172 arg1Of role,for
R7386 T9171 T9184 arg1Of role,in
R7387 T9339 T9335 arg2Of cells,in
R7388 T9339 T9336 arg1Of cells,peripheral
R7389 T9339 T9337 arg1Of cells,blood
R7390 T9339 T9338 arg1Of cells,B
R7391 T9172 T9183 arg1Of for,and
R7392 T9342 T9341 arg1Of PCR,real-time
R7393 T9342 T9344 arg1Of PCR,and
R7394 T9174 T9172 arg2Of proteins,for
R7395 T9344 T9340 arg2Of and,by
R7396 T9344 T9343 arg1Of and,","
R7397 T9345 T9344 arg2Of report,and
R7398 T9345 T9346 arg1Of report,here
R7399 T9174 T9173 arg1Of proteins,Id
R7400 T9348 T9340 arg3Of upregulation,by
R7401 T9348 T9347 arg1Of upregulation,the
R7402 T9348 T9349 arg1Of upregulation,of
R7403 T9348 T9353 arg1Of upregulation,after
R7404 T9348 T9355 arg1Of upregulation,with
R7405 T9174 T9175 arg1Of proteins,in
R7406 T9177 T9175 arg2Of regulation,in
R7407 T9352 T9349 arg2Of transcripts,of
R7408 T9352 T9350 arg1Of transcripts,endogenous
R7409 T9352 T9351 arg1Of transcripts,BMP-6
R7410 T9354 T9353 arg2Of stimulation,after
R7411 T9356 T9357 arg1Of FCS,","
R7412 T9357 T9355 arg2Of ",",with
R7413 T9357 T9360 arg1Of ",",and
R7414 T9357 T9361 arg1Of ",",","
R7415 T9357 T9363 arg1Of ",",importantly
R7416 T9359 T9357 arg2Of AB-serum,","
R7417 T9359 T9358 arg1Of AB-serum,human
R7418 T9177 T9176 arg1Of regulation,the
R7419 T9177 T9178 arg1Of regulation,of
R7420 T9182 T9178 arg2Of homeostasis,of
R7421 T9363 T9362 arg1Of importantly,most
R7422 T9369 T9368 arg1Of attempts,our
R7423 T9369 T9370 modOf attempts,to
R7424 T9369 T9375 arg1Of attempts,were
R7425 T9369 T9376 arg1Of attempts,unsuccessful
R7426 T9182 T9179 arg1Of homeostasis,normal
R7427 T9371 T9370 arg1Of study,to
R7428 T9182 T9180 arg1Of homeostasis,B
R7429 T9182 T9181 arg1Of homeostasis,cell
R7430 T9184 T9183 arg2Of in,and
R7431 T9374 T9371 arg2Of levels,study
R7432 T9374 T9372 arg1Of levels,BMP-6
R7433 T9374 T9373 arg1Of levels,protein
R7434 T9375 T9366 arg1Of were,However
R7435 T9375 T9367 arg1Of were,","
R7436 T9376 T9375 arg2Of unsuccessful,were
R7437 T9376 T9378 arg1Of unsuccessful,to
R7438 T9378 T9377 arg1Of to,due
R7439 T9379 T9378 arg2Of problems,to
R7440 T9379 T9380 arg1Of problems,with
R7441 T9185 T9184 arg2Of diseases,in
R7442 T9185 T9186 arg1Of diseases,","
R7443 T9382 T9381 arg1Of binding,unspecific
R7444 T9382 T9383 arg1Of binding,of
R7445 T9382 T9389 arg1Of binding,and
R7446 T9185 T9187 arg1Of diseases,where
R7447 T9481 T9466 arg1Of suggested,In
R7448 T9481 T9469 arg1Of suggested,","
R7449 T9481 T9480 arg2Of suggested,was
R7450 T9386 T9383 arg2Of antibodies,of
R7451 T9386 T9384 arg1Of antibodies,the
R7452 T9386 T9385 arg1Of antibodies,anti-BMP-6
R7453 T9386 T9387 arg2Of antibodies,tested
R7454 T9483 T9482 arg1Of upregulation,The
R7455 T9389 T9380 arg2Of and,with
R7456 T9389 T9388 arg1Of and,","
R7457 T9390 T9389 arg2Of lack,and
R7458 T9390 T9391 arg1Of lack,of
R7459 T9393 T9391 arg2Of staining,of
R7460 T9393 T9392 arg1Of staining,specific
R7461 T9393 T9394 arg1Of staining,in
R7462 T9483 T9484 arg1Of upregulation,of
R7463 T9396 T9394 arg2Of cells,in
R7464 T9396 T9395 arg1Of cells,control
R7465 T9396 T9397 arg2Of cells,known
R7466 T9483 T9487 arg1Of upregulation,after
R7467 T9396 T9399 arg1Of cells,express
R7468 T9483 T9489 arg1Of upregulation,is
R7469 T9483 T9490 arg1Of upregulation,of
R7470 T9486 T9484 arg2Of BMP-6-transcripts,of
R7471 T9399 T9397 arg3Of express,known
R7472 T9399 T9398 arg1Of express,to
R7473 T9401 T9399 arg2Of mRNA,express
R7474 T9401 T9400 arg1Of mRNA,BMP-6
R7475 T9486 T9485 arg1Of BMP-6-transcripts,the
R7476 T9403 T9402 arg2Of contrast,In
R7477 T9488 T9487 arg2Of IgM-crosslinking,after
R7478 T9489 T9493 arg1Of is,[
R7479 T9407 T9405 arg1Of protein,the
R7480 T9407 T9406 arg1Of protein,recombinant
R7481 T9407 T9408 arg1Of protein,was
R7482 T9407 T9410 arg2Of protein,detected
R7483 T9410 T9402 arg1Of detected,In
R7484 T9410 T9404 arg1Of detected,","
R7485 T9410 T9408 arg2Of detected,was
R7486 T9410 T9409 arg1Of detected,readily
R7487 T9490 T9489 arg2Of of,is
R7488 T9413 T9411 arg2Of respect,In
R7489 T9413 T9412 arg1Of respect,that
R7490 T9492 T9490 arg2Of interest,of
R7491 T9416 T9415 arg1Of investigators,few
R7492 T9416 T9417 arg1Of investigators,have
R7493 T9416 T9418 arg1Of investigators,detected
R7494 T9418 T9411 arg1Of detected,In
R7495 T9418 T9414 arg1Of detected,","
R7496 T9418 T9417 arg2Of detected,have
R7497 T9492 T9491 arg1Of interest,pathophysiologic
R7498 T9420 T9418 arg2Of protein,detected
R7499 T9420 T9419 arg1Of protein,BMP-6
R7500 T9420 T9421 arg1Of protein,in
R7501 T9494 T9493 arg2Of 12,[
R7502 T9420 T9425 arg1Of protein,in
R7503 T9495 T9493 arg3Of ],[
R7504 T9421 T9423 arg1Of in,","
R7505 T9422 T9421 arg2Of humans,in
R7506 T9497 T9496 arg1Of loss,A
R7507 T9425 T9423 arg2Of in,","
R7508 T9425 T9424 arg1Of in,especially
R7509 T9427 T9425 arg2Of tissue,in
R7510 T9427 T9426 arg1Of tissue,non-pathogenic
R7511 T9429 T9428 arg1Of possibility,The
R7512 T9429 T9430 arg1Of possibility,of
R7513 T9429 T9436 arg1Of possibility,is
R7514 T9429 T9437 arg1Of possibility,in
R7515 T9497 T9498 arg1Of loss,of
R7516 T9432 T9430 arg2Of production,of
R7517 T9432 T9431 arg1Of production,BMP-6
R7518 T9432 T9433 arg1Of production,in
R7519 T9497 T9500 arg1Of loss,has
R7520 T9497 T9501 arg1Of loss,been
R7521 T9435 T9433 arg2Of B-cells,in
R7522 T9497 T9502 arg2Of loss,suggested
R7523 T9435 T9434 arg1Of B-cells,human
R7524 T9497 T9504 arg1Of loss,be
R7525 T9437 T9436 arg2Of in,is
R7526 T9438 T9437 arg2Of line,in
R7527 T9438 T9439 arg1Of line,with
R7528 T9499 T9498 arg2Of TGF-β-responsiveness,of
R7529 T9442 T9439 arg2Of work,with
R7530 T9442 T9440 arg1Of work,a
R7531 T9442 T9441 arg1Of work,recent
R7532 T9442 T9443 arg1Of work,that
R7533 T9442 T9444 arg1Of work,reported
R7534 T9502 T9500 arg2Of suggested,has
R7535 T9444 T9453 arg1Of reported,","
R7536 T9444 T9454 modOf reported,infiltrating
R7537 T9446 T9444 arg2Of production,reported
R7538 T9446 T9445 arg1Of production,the
R7539 T9446 T9447 arg1Of production,of
R7540 T9446 T9449 arg1Of production,in
R7541 T9448 T9447 arg2Of BMP-6,of
R7542 T9502 T9501 arg2Of suggested,been
R7543 T9502 T9511 arg1Of suggested,[
R7544 T9452 T9449 arg2Of cells,in
R7545 T9452 T9450 arg1Of cells,mouse
R7546 T9452 T9451 arg1Of cells,B
R7547 T9502 T9514 arg1Of suggested,and
R7548 T9504 T9502 arg3Of be,suggested
R7549 T9457 T9454 arg2Of marrow,infiltrating
R7550 T9457 T9455 arg1Of marrow,the
R7551 T9457 T9456 arg1Of marrow,bone
R7552 T9457 T9458 arg1Of marrow,of
R7553 T9504 T9503 arg1Of be,to
R7554 T9459 T9458 arg2Of mice,of
R7555 T9459 T9460 arg1Of mice,with
R7556 T9507 T9504 arg2Of contribution,be
R7557 T9462 T9460 arg2Of arthritis,with
R7558 T9462 T9461 arg1Of arthritis,inflammatory
R7559 T9462 T9463 arg1Of arthritis,[
R7560 T9464 T9463 arg2Of 43,[
R7561 T9465 T9463 arg3Of ],[
R7562 T9468 T9466 arg2Of study,In
R7563 T9468 T9467 arg1Of study,this
R7564 T9507 T9505 arg1Of contribution,a
R7565 T9507 T9506 arg1Of contribution,critical
R7566 T9471 T9470 arg1Of role,a
R7567 T9507 T9508 arg1Of contribution,to
R7568 T9510 T9508 arg2Of transformation,to
R7569 T9471 T9472 arg1Of role,for
R7570 T9471 T9480 arg1Of role,was
R7571 T9471 T9481 arg2Of role,suggested
R7572 T9510 T9509 arg1Of transformation,malignant
R7573 T9473 T9472 arg2Of BMPs,for
R7574 T9512 T9511 arg2Of "47,48",[
R7575 T9473 T9474 arg1Of BMPs,in
R7576 T9513 T9511 arg3Of ],[
R7577 T9477 T9474 arg2Of process,in
R7578 T9477 T9475 arg1Of process,the
R7579 T9477 T9476 arg1Of process,inflammatoric
R7580 T9477 T9478 arg1Of process,of
R7581 T9479 T9478 arg2Of arthritis,of
R7582 T9517 T9515 arg1Of mechanisms,similar
R7583 T9517 T9516 arg1Of mechanisms,oncogenic
R7584 T9517 T9518 arg1Of mechanisms,have
R7585 T9517 T9519 arg1Of mechanisms,been
R7586 T9577 T9576 arg1Of context,cellular
R7587 T9577 T9578 arg1Of context,of
R7588 T9577 T9583 arg1Of context,might
R7589 T9577 T9584 arg1Of context,define
R7590 T9517 T9520 arg2Of mechanisms,postulated
R7591 T9520 T9514 arg2Of postulated,and
R7592 T9582 T9578 arg2Of cell,of
R7593 T9582 T9579 arg1Of cell,the
R7594 T9582 T9580 arg1Of cell,BMP
R7595 T9582 T9581 arg1Of cell,target
R7596 T9584 T9574 arg2Of define,indicating
R7597 T9584 T9575 arg1Of define,that
R7598 T9584 T9583 arg2Of define,might
R7599 T9520 T9518 arg2Of postulated,have
R7600 T9520 T9519 arg2Of postulated,been
R7601 T9520 T9521 arg1Of postulated,for
R7602 T9588 T9584 arg2Of effects,define
R7603 T9588 T9585 arg1Of effects,the
R7604 T9588 T9586 arg1Of effects,various
R7605 T9588 T9587 arg2Of effects,observed
R7606 T9589 T9591 arg1Of In,to
R7607 T9590 T9589 arg2Of contrast,In
R7608 T9522 T9521 arg2Of BMPs,for
R7609 T9593 T9589 arg3Of upregulation,In
R7610 T9593 T9592 arg1Of upregulation,the
R7611 T9593 T9594 arg1Of upregulation,of
R7612 T9596 T9594 arg2Of transcript,of
R7613 T9596 T9595 arg1Of transcript,BMP-6
R7614 T9596 T9597 arg1Of transcript,in
R7615 T9523 T9524 arg1Of Lines,of
R7616 T9599 T9597 arg2Of cells,in
R7617 T9599 T9598 arg1Of cells,B
R7618 T9523 T9526 arg1Of Lines,suggest
R7619 T9525 T9524 arg2Of evidence,of
R7620 T9601 T9602 arg1Of we,were
R7621 T9601 T9604 arg1Of we,able
R7622 T9601 T9606 arg1Of we,detect
R7623 T9526 T9527 arg1Of suggest,[
R7624 T9601 T9632 arg1Of we,consistent
R7625 T9602 T9589 arg1Of were,In
R7626 T9526 T9530 arg1Of suggest,that
R7627 T9602 T9600 arg1Of were,","
R7628 T9602 T9603 arg1Of were,not
R7629 T9602 T9631 arg1Of were,","
R7630 T9602 T9632 modOf were,consistent
R7631 T9602 T9648 arg1Of were,[
R7632 T9604 T9602 arg2Of able,were
R7633 T9528 T9527 arg2Of 49,[
R7634 T9606 T9604 arg2Of detect,able
R7635 T9606 T9605 arg1Of detect,to
R7636 T9608 T9606 arg2Of transcripts,detect
R7637 T9608 T9607 arg1Of transcripts,BMP-6
R7638 T9608 T9609 arg1Of transcripts,in
R7639 T9529 T9527 arg3Of ],[
R7640 T9533 T9531 arg2Of stages,at
R7641 T9613 T9614 arg1Of CD4+,or
R7642 T9615 T9614 arg2Of CD8+,or
R7643 T9617 T9609 arg2Of cells,in
R7644 T9617 T9610 arg1Of cells,human
R7645 T9617 T9611 arg1Of cells,peripheral
R7646 T9617 T9612 arg1Of cells,blood
R7647 T9617 T9613 arg1Of cells,CD4+
R7648 T9617 T9615 arg1Of cells,CD8+
R7649 T9617 T9616 arg1Of cells,T
R7650 T9617 T9618 arg1Of cells,(
R7651 T9619 T9620 arg1Of resting,or
R7652 T9533 T9532 arg1Of stages,early
R7653 T9533 T9534 arg1Of stages,of
R7654 T9621 T9620 arg2Of stimulated,or
R7655 T9621 T9622 arg1Of stimulated,with
R7656 T9621 T9626 arg1Of stimulated,;
R7657 T9623 T9624 arg1Of anti-CD3,and
R7658 T9624 T9622 arg2Of and,with
R7659 T9625 T9624 arg2Of anti-CD28,and
R7660 T9535 T9534 arg2Of carcinogenesis,of
R7661 T9627 T9618 arg2Of data,(
R7662 T9627 T9619 arg1Of data,resting
R7663 T9627 T9621 arg2Of data,stimulated
R7664 T9627 T9629 arg2Of data,shown
R7665 T9629 T9628 arg1Of shown,not
R7666 T9630 T9618 arg3Of ),(
R7667 T9537 T9538 arg1Of BMP-6,is
R7668 T9632 T9633 arg1Of consistent,with
R7669 T9537 T9545 arg1Of BMP-6,suppresses
R7670 T9635 T9633 arg2Of findings,with
R7671 T9635 T9634 arg1Of findings,the
R7672 T9635 T9636 arg1Of findings,in
R7673 T9635 T9646 arg1Of findings,in
R7674 T9538 T9539 arg1Of is,not
R7675 T9639 T9637 arg1Of lines,T
R7676 T9639 T9638 arg1Of lines,cell
R7677 T9639 T9640 arg1Of lines,[
R7678 T9639 T9643 arg1Of lines,and
R7679 T9538 T9544 arg1Of is,but
R7680 T9641 T9640 arg2Of 20,[
R7681 T9642 T9640 arg3Of ],[
R7682 T9542 T9538 arg2Of promoter,is
R7683 T9643 T9636 arg2Of and,in
R7684 T9645 T9643 arg2Of cells,and
R7685 T9645 T9644 arg1Of cells,T
R7686 T9647 T9646 arg2Of mice,in
R7687 T9649 T9648 arg2Of 43,[
R7688 T9542 T9540 arg1Of promoter,a
R7689 T9650 T9648 arg3Of ],[
R7690 T9542 T9541 arg1Of promoter,tumour
R7691 T9544 T9526 arg2Of but,suggest
R7692 T9654 T9651 arg1Of sources,Other
R7693 T9654 T9652 arg1Of sources,potential
R7694 T9654 T9653 arg1Of sources,BMP-6
R7695 T9654 T9655 arg1Of sources,for
R7696 T9654 T9661 arg1Of sources,might
R7697 T9654 T9662 arg1Of sources,be
R7698 T9544 T9531 arg1Of but,at
R7699 T9658 T9655 arg2Of cells,for
R7700 T9658 T9656 arg1Of cells,mature
R7701 T9658 T9657 arg1Of cells,B
R7702 T9658 T9660 arg1Of cells,vivo
R7703 T9544 T9536 arg1Of but,","
R7704 T9660 T9659 arg1Of vivo,in
R7705 T9544 T9543 arg1Of but,","
R7706 T9662 T9661 arg2Of be,might
R7707 T9662 T9671 arg1Of be,with
R7708 T9664 T9662 arg2Of cells,be
R7709 T9664 T9663 arg1Of cells,other
R7710 T9664 T9665 arg1Of cells,of
R7711 T9545 T9544 arg2Of suppresses,but
R7712 T9668 T9669 arg1Of system,or
R7713 T9669 T9665 arg2Of or,of
R7714 T9669 T9666 arg1Of or,the
R7715 T9669 T9667 arg1Of or,immune
R7716 T9546 T9547 arg1Of benign,and
R7717 T9670 T9669 arg2Of tissue,or
R7718 T9671 T9673 arg1Of with,to
R7719 T9672 T9671 arg2Of contact,with
R7720 T9548 T9547 arg2Of malignant,and
R7721 T9550 T9545 arg2Of outgrowth,suppresses
R7722 T9550 T9546 arg1Of outgrowth,benign
R7723 T9550 T9548 arg1Of outgrowth,malignant
R7724 T9550 T9549 arg1Of outgrowth,tumour
R7725 T9552 T9551 arg1Of findings,These
R7726 T9676 T9671 arg3Of system,with
R7727 T9676 T9674 arg1Of system,the
R7728 T9676 T9675 arg1Of system,hematopoietic
R7729 T9679 T9678 arg1Of recognized,well
R7730 T9680 T9677 arg1Of source,One
R7731 T9680 T9679 arg1Of source,recognized
R7732 T9680 T9681 arg1Of source,for
R7733 T9680 T9684 arg1Of source,is
R7734 T9552 T9553 arg1Of findings,are
R7735 T9552 T9554 arg1Of findings,in
R7736 T9683 T9681 arg2Of production,for
R7737 T9683 T9682 arg1Of production,BMP-6
R7738 T9553 T9573 arg1Of are,","
R7739 T9553 T9574 modOf are,indicating
R7740 T9684 T9692 arg1Of is,[
R7741 T9554 T9553 arg2Of in,are
R7742 T9556 T9554 arg2Of agreement,in
R7743 T9687 T9686 arg1Of bone,human
R7744 T9687 T9688 arg1Of bone,and
R7745 T9688 T9684 arg2Of and,is
R7746 T9688 T9685 arg1Of and,the
R7747 T9556 T9555 arg1Of agreement,good
R7748 T9691 T9688 arg2Of stroma,and
R7749 T9691 T9689 arg1Of stroma,bone
R7750 T9691 T9690 arg1Of stroma,marrow
R7751 T9556 T9557 arg1Of agreement,with
R7752 T9693 T9692 arg2Of "51,8",[
R7753 T9559 T9557 arg2Of findings,with
R7754 T9694 T9692 arg3Of ],[
R7755 T9559 T9558 arg1Of findings,previous
R7756 T9559 T9560 arg1Of findings,for
R7757 T9698 T9717 arg1Of is,and
R7758 T9699 T9698 arg2Of noteworthy,is
R7759 T9564 T9560 arg2Of members,for
R7760 T9705 T9701 arg1Of cells,human
R7761 T9705 T9702 arg1Of cells,umbilical
R7762 T9705 T9703 arg1Of cells,vein
R7763 T9705 T9704 arg1Of cells,endothelial
R7764 T9705 T9706 arg1Of cells,(
R7765 T9705 T9710 arg1Of cells,express
R7766 T9707 T9706 arg2Of HUVEC,(
R7767 T9708 T9706 arg3Of ),(
R7768 T9710 T9697 arg1Of express,it
R7769 T9710 T9698 arg1Of express,is
R7770 T9710 T9699 arg1Of express,noteworthy
R7771 T9710 T9700 arg1Of express,that
R7772 T9710 T9709 arg1Of express,highly
R7773 T9564 T9561 arg1Of members,other
R7774 T9712 T9710 arg2Of mRNA,express
R7775 T9564 T9562 arg1Of members,TGF-β
R7776 T9712 T9711 arg1Of mRNA,BMP-6
R7777 T9712 T9713 arg1Of mRNA,[
R7778 T9714 T9713 arg2Of 52,[
R7779 T9564 T9563 arg1Of members,family
R7780 T9715 T9713 arg3Of ],[
R7781 T9564 T9565 arg1Of members,","
R7782 T9564 T9566 arg1Of members,including
R7783 T9717 T9695 arg1Of and,Furthermore
R7784 T9717 T9696 arg1Of and,","
R7785 T9717 T9716 arg1Of and,","
R7786 T9567 T9568 arg1Of TGF-β1,and
R7787 T9719 T9718 arg1Of endothelium,vascular
R7788 T9719 T9720 arg1Of endothelium,has
R7789 T9719 T9721 arg1Of endothelium,been
R7790 T9719 T9722 arg2Of endothelium,reported
R7791 T9719 T9724 arg1Of endothelium,produce
R7792 T9722 T9717 arg2Of reported,and
R7793 T9722 T9720 arg2Of reported,has
R7794 T9722 T9721 arg2Of reported,been
R7795 T9724 T9722 arg3Of produce,reported
R7796 T9724 T9723 arg1Of produce,to
R7797 T9724 T9726 arg1Of produce,[
R7798 T9725 T9724 arg2Of BMP-6,produce
R7799 T9568 T9566 arg2Of and,including
R7800 T9727 T9726 arg2Of 53,[
R7801 T9568 T9570 arg1Of and,[
R7802 T9728 T9726 arg3Of ],[
R7803 T9569 T9568 arg2Of BMP-4,and
R7804 T9730 T9729 arg1Of studies,These
R7805 T9730 T9731 arg1Of studies,might
R7806 T9730 T9732 arg1Of studies,imply
R7807 T9732 T9731 arg2Of imply,might
R7808 T9734 T9732 arg2Of role,imply
R7809 T9734 T9733 arg1Of role,a
R7810 T9734 T9735 arg1Of role,for
R7811 T9734 T9737 arg1Of role,in
R7812 T9571 T9570 arg2Of 50,[
R7813 T9736 T9735 arg2Of BMP-6,for
R7814 T9739 T9737 arg2Of migration,in
R7815 T9739 T9738 arg1Of migration,transendothelial
R7816 T9739 T9740 arg1Of migration,of
R7817 T9572 T9570 arg3Of ],[
R7818 T9772 T9773 arg1Of neutrophil,and
R7819 T9742 T9740 arg2Of cells,of
R7820 T9742 T9741 arg1Of cells,B
R7821 T9744 T9743 arg1Of mRNA,BMP-6
R7822 T9744 T9745 arg1Of mRNA,has
R7823 T9744 T9746 arg1Of mRNA,been
R7824 T9744 T9747 arg2Of mRNA,demonstrated
R7825 T9747 T9745 arg2Of demonstrated,has
R7826 T9747 T9746 arg2Of demonstrated,been
R7827 T9747 T9748 arg1Of demonstrated,in
R7828 T9747 T9756 arg1Of demonstrated,in
R7829 T9748 T9754 arg1Of in,but
R7830 T9752 T9748 arg2Of lines,in
R7831 T9752 T9749 arg1Of lines,murine
R7832 T9752 T9750 arg1Of lines,macrophage
R7833 T9752 T9751 arg1Of lines,cell
R7834 T9754 T9753 arg1Of but,","
R7835 T9773 T9771 arg2Of and,of
R7836 T9756 T9754 arg2Of in,but
R7837 T9756 T9755 arg1Of in,not
R7838 T9775 T9773 arg2Of origin,and
R7839 T9757 T9756 arg2Of humans,in
R7840 T9757 T9758 arg1Of humans,[
R7841 T9775 T9774 arg1Of origin,monocytic
R7842 T9778 T9761 arg1Of described,In
R7843 T9759 T9758 arg2Of 54,[
R7844 T9760 T9758 arg3Of ],[
R7845 T9761 T9763 arg1Of In,with
R7846 T9762 T9761 arg2Of accordance,In
R7847 T9778 T9766 arg1Of described,","
R7848 T9778 T9776 arg2Of described,have
R7849 T9765 T9761 arg3Of findings,In
R7850 T9778 T9777 arg2Of described,been
R7851 T9765 T9764 arg1Of findings,these
R7852 T9780 T9778 arg3Of be,described
R7853 T9780 T9779 arg1Of be,to
R7854 T9770 T9767 arg1Of lines,other
R7855 T9770 T9768 arg1Of lines,human
R7856 T9770 T9769 arg1Of lines,cell
R7857 T9770 T9771 arg1Of lines,of
R7858 T9770 T9776 arg1Of lines,have
R7859 T9770 T9777 arg1Of lines,been
R7860 T9770 T9778 arg2Of lines,described
R7861 T9770 T9780 arg1Of lines,be
R7862 T9770 T9781 arg1Of lines,negative
R7863 T9780 T9786 arg1Of be,[
R7864 T9781 T9780 arg2Of negative,be
R7865 T9781 T9782 arg1Of negative,for
R7866 T9785 T9782 arg2Of transcript,for
R7867 T9785 T9783 arg1Of transcript,the
R7868 T9785 T9784 arg1Of transcript,BMP-6
R7869 T9787 T9786 arg2Of 20,[
R7872 T9788 T9786 arg3Of ],[
R7873 T9791 T9789 arg2Of knowledge,To
R7878 T9791 T9790 arg1Of knowledge,our
R7880 T9793 T9794 arg1Of there,is
R7882 T9794 T9789 arg1Of is,To
R7885 T9794 T9792 arg1Of is,","
R7887 T9794 T9795 arg1Of is,currently
R7888 T9797 T9794 arg2Of report,is
R7891 T9797 T9796 arg1Of report,no
R7892 T9797 T9798 arg1Of report,about
R7893 T9800 T9798 arg2Of production,about
R7894 T9800 T9799 arg1Of production,BMP-6
R7895 T9800 T9801 arg1Of production,of
R7896 T9804 T9801 arg2Of cells,of
R7897 T9804 T9802 arg1Of cells,human
R7898 T9804 T9803 arg1Of cells,dendritic
R10420 T13414 T13413 arg2Of conclusion,In
R10421 T13417 T13416 arg1Of results,our
R10422 T13417 T13418 arg1Of results,show
R10423 T13418 T13413 arg1Of show,In
R10424 T13418 T13415 arg1Of show,","
R10425 T13420 T13421 arg1Of BMP-6,induces
R10426 T13421 T13418 arg2Of induces,show
R10427 T13421 T13419 arg1Of induces,that
R10428 T13421 T13427 arg1Of induces,in
R10429 T13422 T13421 arg2Of activation,induces
R10430 T13422 T13423 arg1Of activation,of
R10431 T13426 T13423 arg2Of signalling,of
R10432 T13426 T13424 arg1Of signalling,intracellular
R10433 T13426 T13425 arg1Of signalling,Smad
R10434 T13430 T13427 arg2Of B-cells,in
R10435 T13430 T13428 arg1Of B-cells,mature
R10436 T13430 T13429 arg1Of B-cells,human
R10437 T13430 T13431 arg1Of B-cells,with
R10438 T13433 T13431 arg2Of production,with
R10439 T13433 T13432 arg1Of production,consecutive
R10440 T13433 T13434 arg1Of production,of
R10441 T13436 T13434 arg2Of protein,of
R10442 T13436 T13435 arg1Of protein,Id1
R10443 T13439 T13440 arg1Of we,report
R10444 T13440 T13437 arg1Of report,Furthermore
R10445 T13440 T13438 arg1Of report,","
R10446 T13442 T13443 arg1Of BMP-6,has
R10447 T13443 T13440 arg2Of has,report
R10448 T13443 T13441 arg1Of has,that
R10449 T13443 T13447 arg1Of has,in
R10450 T13446 T13443 arg2Of effect,has
R10451 T13446 T13444 arg1Of effect,an
R10452 T13446 T13445 arg1Of effect,antiproliferative
R10453 T13449 T13447 arg2Of cells,in
R10454 T13449 T13448 arg1Of cells,B
R10455 T13449 T13450 arg2Of cells,stimulated
R10456 T13450 T13451 arg1Of stimulated,with
R10457 T13452 T13453 arg1Of anti-IgM,alone
R10458 T13452 T13454 arg1Of anti-IgM,or
R10459 T13454 T13451 arg2Of or,with
R10460 T13457 T13454 arg2Of action,or
R10461 T13457 T13455 arg1Of action,the
R10462 T13457 T13456 arg2Of action,combined
R10463 T13457 T13458 arg1Of action,of
R10464 T13459 T13460 arg1Of anti-IgM,and
R10465 T13460 T13458 arg2Of and,of
R10466 T13461 T13460 arg2Of CD40L,and
R10467 T13464 T13465 arg1Of BMP-6,induces
R10468 T13465 T13462 arg1Of induces,Additionally
R10469 T13465 T13463 arg1Of induces,","
R10470 T13467 T13465 arg2Of death,induces
R10471 T13467 T13466 arg1Of death,cell
R10472 T13467 T13468 arg1Of death,in
R10473 T13472 T13469 arg2Of cells,activated
R10474 T13472 T13470 arg1Of cells,memory
R10475 T13472 T13471 arg1Of cells,B
R10476 T13472 T13473 arg1Of cells,and
R10477 T13473 T13468 arg2Of and,in
R10478 T13475 T13473 arg2Of cells,and
R10479 T13475 T13474 arg1Of cells,Ramos
R10480 T13476 T13477 arg1Of Taken,together
R10481 T13480 T13479 arg1Of results,these
R10482 T13480 T13481 arg1Of results,provide
R10483 T13481 T13476 modOf provide,Taken
R10484 T13481 T13478 arg1Of provide,","
R10485 T13483 T13481 arg2Of rationale,provide
R10486 T13483 T13482 arg1Of rationale,a
R10487 T13483 T13484 modOf rationale,to
R10488 T13486 T13484 arg1Of examine,to
R10489 T13486 T13485 arg1Of examine,further
R10490 T13488 T13486 arg2Of role,examine
R10491 T13488 T13487 arg1Of role,the
R10492 T13488 T13489 arg1Of role,of
R10493 T13488 T13492 arg1Of role,in
R10494 T13488 T13500 arg1Of role,in
R10495 T13491 T13489 arg2Of signalling,of
R10496 T13491 T13490 arg1Of signalling,BMP-6
R10497 T13492 T13499 arg1Of in,as
R10498 T13496 T13492 arg2Of biology,in
R10499 T13496 T13493 arg1Of biology,normal
R10500 T13496 T13494 arg1Of biology,B
R10501 T13496 T13495 arg1Of biology,cell
R10502 T13499 T13497 arg1Of as,as
R10503 T13499 T13498 arg1Of as,well
R10504 T13500 T13499 arg2Of in,as
R10505 T13502 T13500 arg2Of conditions,in
R10506 T13502 T13501 arg1Of conditions,pathologic
R10507 T13502 T13503 arg1Of conditions,like
R10508 T13506 T13504 arg1Of malignancies,B
R10509 T13506 T13505 arg1Of malignancies,cell
R10510 T13506 T13507 arg1Of malignancies,and
R10511 T13507 T13503 arg2Of and,like
R10512 T13509 T13507 arg2Of disorders,and
R10513 T13509 T13508 arg1Of disorders,autoimmune
R10633 T13709 T13708 arg1Of culture,Cell
R10634 T13712 T13710 arg2Of specified,If
R10635 T13712 T13711 arg1Of specified,not
R10636 T13715 T13712 arg2Of cells,specified
R10637 T13715 T13714 arg1Of cells,all
R10638 T13715 T13716 arg1Of cells,were
R10639 T13715 T13717 arg2Of cells,cultured
R10640 T13717 T13710 arg1Of cultured,If
R10641 T13717 T13713 arg1Of cultured,","
R10642 T13717 T13716 arg2Of cultured,were
R10643 T13717 T13718 arg1Of cultured,in
R10644 T13719 T13720 arg1Of X-VIVO,15™
R10645 T13719 T13721 arg1Of X-VIVO,(
R10646 T13722 T13723 arg1Of BioWhittaker,","
R10647 T13723 T13721 arg2Of ",",(
R10648 T13723 T13725 arg1Of ",",","
R10649 T13723 T13726 arg1Of ",",Belgium
R10650 T13724 T13723 arg2Of Verviers,","
R10651 T13727 T13721 arg3Of ),(
R10652 T13729 T13718 arg2Of medium,in
R10653 T13729 T13719 arg1Of medium,X-VIVO
R10654 T13729 T13728 arg1Of medium,serum-free
R10655 T13729 T13730 arg1Of medium,at
R10656 T13731 T13732 arg1Of 37°C,and
R10657 T13732 T13730 arg2Of and,at
R10658 T13732 T13736 arg1Of and,in
R10659 T13733 T13734 arg1Of 5,%
R10660 T13735 T13732 arg2Of CO2,and
R10661 T13735 T13733 arg1Of CO2,5
R10662 T13737 T13736 arg2Of air,in
R10663 T13739 T13738 arg1Of blood,Peripheral
R10664 T13739 T13740 arg1Of blood,was
R10665 T13739 T13741 arg2Of blood,provided
R10666 T13741 T13740 arg2Of provided,was
R10667 T13741 T13750 arg1Of provided,with
R10668 T13745 T13741 arg1Of Bank,provided
R10669 T13745 T13742 arg2Of Bank,by
R10670 T13745 T13743 arg1Of Bank,the
R10671 T13745 T13744 arg1Of Bank,Blood
R10672 T13745 T13746 arg1Of Bank,at
R10673 T13749 T13746 arg2Of Hospital,at
R10674 T13749 T13747 arg1Of Hospital,Buskerud
R10675 T13749 T13748 arg1Of Hospital,Regional
R10676 T13752 T13750 arg2Of agreement,with
R10677 T13752 T13751 arg1Of agreement,formal
R10678 T13752 T13753 arg1Of agreement,by
R10679 T13755 T13757 arg1Of patients,and
R10680 T13757 T13753 arg2Of and,by
R10681 T13757 T13754 arg1Of and,the
R10682 T13757 T13756 arg1Of and,","
R10683 T13757 T13759 arg1Of and,by
R10684 T13758 T13757 arg2Of approval,and
R10685 T13763 T13759 arg2Of committee,by
R10686 T13763 T13760 arg1Of committee,the
R10687 T13763 T13761 arg1Of committee,regional
R10688 T13763 T13762 arg1Of committee,ethics
R10689 T13765 T13764 arg1Of purified,Highly
R10690 T13768 T13765 arg1Of B-lymphocytes,purified
R10691 T13768 T13766 arg1Of B-lymphocytes,resting
R10692 T13768 T13767 arg1Of B-lymphocytes,human
R10693 T13768 T13769 arg1Of B-lymphocytes,(
R10694 T13768 T13773 arg1Of B-lymphocytes,were
R10695 T13768 T13774 arg2Of B-lymphocytes,isolated
R10696 T13768 T13780 arg1Of B-lymphocytes,rosetting
R10697 T13771 T13769 arg2Of cells,(
R10698 T13771 T13770 arg1Of cells,CD19+
R10699 T13772 T13769 arg3Of ),(
R10700 T13774 T13773 arg2Of isolated,were
R10701 T13774 T13775 arg1Of isolated,from
R10702 T13774 T13779 arg1Of isolated,by
R10703 T13778 T13775 arg2Of blood,from
R10704 T13778 T13776 arg1Of blood,the
R10705 T13778 T13777 arg1Of blood,peripheral
R10706 T13780 T13779 arg2Of rosetting,by
R10707 T13780 T13781 arg1Of rosetting,with
R10708 T13780 T13794 arg1Of rosetting,as
R10709 T13780 T13796 arg1Of rosetting,[
R10710 T13783 T13781 arg2Of beads,with
R10711 T13783 T13782 arg1Of beads,immunomagnetic
R10712 T13783 T13784 arg1Of beads,(
R10713 T13786 T13787 arg1Of M450,;
R10714 T13787 T13784 arg2Of ;,(
R10715 T13787 T13785 arg1Of ;,Dynabeads
R10716 T13787 T13791 arg1Of ;,","
R10717 T13787 T13792 arg1Of ;,Norway
R10718 T13788 T13789 arg1Of Dynal,","
R10719 T13789 T13787 arg2Of ",",;
R10720 T13790 T13789 arg2Of Oslo,","
R10721 T13793 T13784 arg3Of ),(
R10722 T13795 T13794 arg2Of described,as
R10723 T13797 T13796 arg2Of 55,[
R10724 T13798 T13796 arg3Of ],[
R10725 T13800 T13799 arg1Of procedure,This
R10726 T13800 T13801 arg1Of procedure,yields
R10727 T13801 T13818 arg1Of yields,as
R10728 T13802 T13803 arg1Of less,than
R10729 T13802 T13805 arg1Of less,%
R10730 T13804 T13803 arg2Of 0.5,than
R10731 T13807 T13802 arg1Of cells,less
R10732 T13807 T13806 arg1Of cells,T
R10733 T13807 T13808 arg1Of cells,","
R10734 T13808 T13814 arg1Of ",",and
R10735 T13809 T13810 arg1Of 0.1,%
R10736 T13812 T13808 arg2Of cells,","
R10737 T13812 T13809 arg1Of cells,0.1
R10738 T13812 T13811 arg1Of cells,NK
R10739 T13814 T13801 arg2Of and,yields
R10740 T13814 T13813 arg1Of and,","
R10741 T13815 T13816 arg1Of 0.5,%
R10742 T13817 T13814 arg2Of monocytes,and
R10743 T13817 T13815 arg1Of monocytes,0.5
R10744 T13819 T13818 arg2Of judged,as
R10745 T13823 T13819 arg1Of staining,judged
R10746 T13823 T13820 arg2Of staining,by
R10747 T13823 T13821 arg1Of staining,indirect
R10748 T13823 T13822 arg1Of staining,immunofluorescence
R10749 T13827 T13824 arg1Of lines,The
R10750 T13827 T13825 arg1Of lines,following
R10751 T13827 T13826 arg1Of lines,cell
R10752 T13827 T13828 arg1Of lines,from
R10753 T13827 T13832 arg1Of lines,were
R10754 T13827 T13833 arg2Of lines,maintained
R10755 T13827 T13870 arg1Of lines,serum-starved
R10756 T13827 T13877 arg2Of lines,cultured
R10757 T13827 T13882 arg1Of lines,included
R10758 T13831 T13828 arg2Of malignancies,from
R10759 T13831 T13829 arg1Of malignancies,human
R10760 T13831 T13830 arg1Of malignancies,lymphoid
R10761 T13833 T13834 arg1Of maintained,in
R10762 T13833 T13869 arg1Of maintained,but
R10763 T13835 T13834 arg2Of RPMI,in
R10764 T13835 T13836 arg1Of RPMI,1640
R10765 T13835 T13837 arg1Of RPMI,(
R10766 T13835 T13846 arg2Of RPMI,supplemented
R10767 T13840 T13837 arg2Of GmbH,(
R10768 T13840 T13838 arg1Of GmbH,PAA
R10769 T13840 T13839 arg1Of GmbH,Laboratories
R10770 T13840 T13841 arg1Of GmbH,","
R10771 T13842 T13841 arg2Of Pasching,","
R10772 T13842 T13843 arg1Of Pasching,","
R10773 T13842 T13844 arg1Of Pasching,Austria
R10774 T13845 T13837 arg3Of ),(
R10775 T13846 T13847 arg1Of supplemented,with
R10776 T13848 T13849 arg1Of 10,%
R10777 T13852 T13848 arg1Of serum,10
R10778 T13852 T13850 arg1Of serum,foetal
R10779 T13852 T13851 arg1Of serum,bovine
R10780 T13852 T13853 arg1Of serum,(
R10781 T13852 T13856 arg1Of serum,","
R10782 T13854 T13853 arg2Of FCS,(
R10783 T13855 T13853 arg3Of ),(
R10784 T13856 T13862 arg1Of ",",and
R10785 T13860 T13856 arg2Of G,","
R10786 T13860 T13857 arg1Of G,100
R10787 T13860 T13858 arg1Of G,units/ml
R10788 T13860 T13859 arg1Of G,penicillin
R10789 T13862 T13847 arg2Of and,with
R10790 T13862 T13861 arg1Of and,","
R10791 T13864 T13862 arg2Of units/ml,and
R10792 T13864 T13863 arg1Of units/ml,100
R10793 T13864 T13865 arg1Of units/ml,of
R10794 T13867 T13865 arg2Of sulphate,of
R10795 T13867 T13866 arg1Of sulphate,streptomycin
R10796 T13869 T13868 arg1Of but,","
R10797 T13869 T13871 arg1Of but,for
R10798 T13869 T13876 arg1Of but,and
R10799 T13870 T13869 arg2Of serum-starved,but
R10800 T13874 T13872 arg1Of four,at
R10801 T13874 T13873 arg1Of four,least
R10802 T13875 T13871 arg2Of hours,for
R10803 T13875 T13874 arg1Of hours,four
R10804 T13876 T13832 arg2Of and,were
R10805 T13876 T13881 arg1Of and,when
R10806 T13877 T13876 arg2Of cultured,and
R10807 T13877 T13878 arg1Of cultured,in
R10808 T13879 T13878 arg2Of X-VIVO,in
R10809 T13879 T13880 arg1Of X-VIVO,15™
R10810 T13882 T13881 arg2Of included,when
R10811 T13882 T13883 arg1Of included,in
R10812 T13884 T13883 arg2Of experiments,in
R10813 T13884 T13885 arg1Of experiments,:
R10814 T13890 T13886 arg1Of Ramos,EBV-negative
R10815 T13890 T13887 arg1Of Ramos,BL
R10816 T13890 T13888 arg1Of Ramos,cell
R10817 T13890 T13889 arg1Of Ramos,lines
R10818 T13890 T13891 arg1Of Ramos,(
R10819 T13890 T13895 arg1Of Ramos,","
R10820 T13892 T13891 arg2Of ECACC,(
R10821 T13892 T13893 arg1Of ECACC,85030802
R10822 T13894 T13891 arg3Of ),(
R10823 T13895 T13882 arg2Of ",",included
R10824 T13896 T13895 arg2Of HL60,","
R10825 T13896 T13897 arg1Of HL60,(
R10826 T13898 T13897 arg2Of JCRB0085,(
R10827 T13899 T13897 arg3Of ),(
R11164 T14428 T14429 arg2Of Antibodies,used
R11165 T14429 T14430 arg1Of used,for
R11166 T14433 T14431 arg1Of analysis,flow
R11167 T14433 T14432 arg1Of analysis,cytometric
R11168 T14433 T14434 arg1Of analysis,and
R11169 T14434 T14430 arg2Of and,for
R11170 T14436 T14434 arg2Of analysis,and
R11171 T14436 T14435 arg1Of analysis,immunoblot
R11172 T14437 T14438 arg1Of Antibodies,against
R11173 T14437 T14451 arg1Of Antibodies,were
R11174 T14437 T14452 arg2Of Antibodies,purchased
R11175 T14441 T14439 arg1Of BMP-receptors,the
R11176 T14441 T14440 arg1Of BMP-receptors,human
R11177 T14442 T14443 arg1Of Act-RIA,","
R11178 T14443 T14445 arg1Of ",",","
R11179 T14444 T14443 arg2Of BMP-RIB,","
R11180 T14445 T14447 arg1Of ",",","
R11181 T14446 T14445 arg2Of BMPR-II,","
R11182 T14447 T14449 arg1Of ",",and
R11183 T14448 T14447 arg2Of Act-RIIA,","
R11184 T14449 T14438 arg2Of and,against
R11185 T14449 T14441 arg1Of and,BMP-receptors
R11186 T14450 T14449 arg2Of Act-RIIb,and
R11187 T14452 T14451 arg2Of purchased,were
R11188 T14452 T14453 arg1Of purchased,from
R11189 T14457 T14453 arg2Of Systems,from
R11190 T14457 T14454 arg1Of Systems,R
R11191 T14457 T14455 arg1Of Systems,&
R11192 T14457 T14456 arg1Of Systems,D
R11193 T14457 T14458 arg1Of Systems,(
R11194 T14459 T14458 arg2Of Abingdon,(
R11195 T14459 T14460 arg1Of Abingdon,","
R11196 T14459 T14461 arg1Of Abingdon,UK
R11197 T14462 T14458 arg3Of ),(
R11198 T14463 T14464 arg1Of Detection,of
R11199 T14463 T14467 arg1Of Detection,has
R11200 T14463 T14468 arg1Of Detection,been
R11201 T14463 T14469 arg2Of Detection,tried
R11202 T14466 T14464 arg2Of BMP-6-protein,of
R11203 T14466 T14465 arg1Of BMP-6-protein,the
R11204 T14469 T14467 arg2Of tried,has
R11205 T14469 T14468 arg2Of tried,been
R11206 T14469 T14470 arg1Of tried,with
R11207 T14473 T14470 arg2Of antibodies,with
R11208 T14473 T14471 arg1Of antibodies,the
R11209 T14473 T14472 arg1Of antibodies,following
R11210 T14473 T14474 arg1Of antibodies,:
R11211 T14477 T14475 arg1Of anti-BMP-6,goat
R11212 T14477 T14476 arg1Of anti-BMP-6,polyclonal
R11213 T14477 T14478 arg1Of anti-BMP-6,(
R11214 T14477 T14489 arg1Of anti-BMP-6,","
R11215 T14480 T14478 arg2Of Cruz,(
R11216 T14480 T14479 arg1Of Cruz,Santa
R11217 T14480 T14481 arg1Of Cruz,","
R11218 T14480 T14486 arg1Of Cruz,","
R11219 T14480 T14487 arg1Of Cruz,USA
R11220 T14483 T14481 arg2Of Diego,","
R11221 T14483 T14482 arg1Of Diego,San
R11222 T14483 T14484 arg1Of Diego,","
R11223 T14485 T14484 arg2Of CA,","
R11224 T14488 T14478 arg3Of ),(
R11225 T14489 T14474 arg2Of ",",:
R11226 T14489 T14497 arg1Of ",",from
R11227 T14492 T14490 arg1Of anti-BMP-6,monoclonal
R11228 T14492 T14491 arg1Of anti-BMP-6,mouse
R11229 T14492 T14493 arg1Of anti-BMP-6,and
R11230 T14493 T14489 arg2Of and,","
R11231 T14496 T14493 arg2Of anti-BMP-6,and
R11232 T14496 T14494 arg1Of anti-BMP-6,polyclonal
R11233 T14496 T14495 arg1Of anti-BMP-6,goat
R11234 T14501 T14498 arg1Of Systems,R
R11235 T14501 T14499 arg1Of Systems,&
R11236 T14501 T14500 arg1Of Systems,D
R11237 T14501 T14502 arg1Of Systems,(
R11238 T14501 T14508 arg1Of Systems,and
R11239 T14503 T14502 arg2Of Abingdon,(
R11240 T14503 T14504 arg1Of Abingdon,","
R11241 T14503 T14505 arg1Of Abingdon,UK
R11242 T14506 T14502 arg3Of ),(
R11243 T14508 T14497 arg2Of and,from
R11244 T14508 T14507 arg1Of and,","
R11245 T14511 T14508 arg2Of anti-BMP-6,and
R11246 T14511 T14509 arg1Of anti-BMP-6,mouse
R11247 T14511 T14510 arg1Of anti-BMP-6,monoclonal
R11248 T14511 T14512 arg1Of anti-BMP-6,(
R11249 T14515 T14512 arg2Of Inc,(
R11250 T14515 T14513 arg1Of Inc,Chemicon
R11251 T14515 T14514 arg1Of Inc,International
R11252 T14515 T14516 arg1Of Inc,","
R11253 T14515 T14520 arg1Of Inc,","
R11254 T14515 T14521 arg1Of Inc,USA
R11255 T14517 T14518 arg1Of Temecula,","
R11256 T14518 T14516 arg2Of ",",","
R11257 T14519 T14518 arg2Of CA,","
R11258 T14522 T14512 arg3Of ),(
R11259 T14523 T14524 arg1Of Characterisation,of
R11260 T14523 T14527 arg1Of Characterisation,was
R11261 T14523 T14528 arg2Of Characterisation,done
R11262 T14526 T14524 arg2Of pathways,of
R11263 T14526 T14525 arg1Of pathways,BMP-signalling
R11264 T14528 T14527 arg2Of done,was
R11265 T14528 T14540 arg1Of done,(
R11266 T14530 T14528 arg1Of use,done
R11267 T14530 T14529 arg2Of use,by
R11268 T14530 T14531 arg1Of use,of
R11269 T14532 T14531 arg2Of anti-phospho-Smad1,of
R11270 T14532 T14533 arg1Of anti-phospho-Smad1,","
R11271 T14532 T14535 arg1Of anti-phospho-Smad1,","
R11272 T14534 T14533 arg2Of -5,","
R11273 T14538 T14536 arg1Of polyclonal,-and
R11274 T14538 T14537 arg1Of polyclonal,8
R11275 T14539 T14535 arg2Of antibody,","
R11276 T14539 T14538 arg1Of antibody,polyclonal
R11277 T14541 T14542 arg1Of Chemicon,","
R11278 T14542 T14544 arg1Of ",",","
R11279 T14543 T14542 arg2Of Temecula,","
R11280 T14544 T14540 arg2Of ",",(
R11281 T14544 T14546 arg1Of ",",","
R11282 T14544 T14547 arg1Of ",",USA
R11283 T14545 T14544 arg2Of CA,","
R11284 T14548 T14540 arg3Of ),(
R11285 T14550 T14549 arg1Of levels,Expression
R11286 T14550 T14551 arg1Of levels,of
R11287 T14550 T14554 arg1Of levels,were
R11288 T14550 T14555 arg2Of levels,detected
R11289 T14553 T14551 arg2Of proteins,of
R11290 T14553 T14552 arg1Of proteins,Id1–3
R11291 T14555 T14554 arg2Of detected,were
R11292 T14555 T14556 arg1Of detected,with
R11293 T14555 T14560 arg1Of detected,and
R11294 T14559 T14556 arg2Of antibody,with
R11295 T14559 T14557 arg1Of antibody,polyclonal
R11296 T14559 T14558 arg1Of antibody,rabbit
R11297 T14561 T14562 arg1Of detection,was
R11298 T14561 T14563 arg2Of detection,blocked
R11299 T14563 T14560 arg2Of blocked,and
R11300 T14563 T14562 arg2Of blocked,was
R11301 T14563 T14564 arg1Of blocked,with
R11302 T14565 T14564 arg2Of blocking,with
R11303 T14566 T14565 arg2Of peptide,blocking
R11304 T14566 T14567 arg1Of peptide,from
R11305 T14570 T14567 arg2Of Biotechnology,from
R11306 T14570 T14568 arg1Of Biotechnology,Santa
R11307 T14570 T14569 arg1Of Biotechnology,Cruz
R11308 T14570 T14571 arg1Of Biotechnology,(
R11309 T14573 T14571 arg2Of Cruz,(
R11310 T14573 T14572 arg1Of Cruz,Santa
R11311 T14573 T14574 arg1Of Cruz,","
R11312 T14573 T14579 arg1Of Cruz,","
R11313 T14576 T14574 arg2Of Diego,","
R11314 T14576 T14575 arg1Of Diego,San
R11315 T14576 T14577 arg1Of Diego,","
R11316 T14578 T14577 arg2Of CA,","
R11317 T14580 T14579 arg2Of USA,","
R11318 T14581 T14571 arg3Of ),(
R11319 T14584 T14582 arg1Of antibodies,As
R11320 T14584 T14583 arg1Of antibodies,secondary
R11321 T14584 T14585 arg1Of antibodies,served
R11322 T14586 T14587 arg1Of anti-mouse,","
R11323 T14587 T14589 arg1Of ",",or
R11324 T14588 T14587 arg2Of anti-goat,","
R11325 T14590 T14589 arg2Of anti-rabbit,or
R11326 T14593 T14585 arg2Of peroxidase,served
R11327 T14593 T14586 arg1Of peroxidase,anti-mouse
R11328 T14593 T14588 arg1Of peroxidase,anti-goat
R11329 T14593 T14590 arg1Of peroxidase,anti-rabbit
R11330 T14593 T14591 arg1Of peroxidase,IgG-
R11331 T14593 T14592 arg1Of peroxidase,horseradish
R11332 T14593 T14594 arg1Of peroxidase,(
R11333 T14593 T14597 arg1Of peroxidase,from
R11334 T14593 T14600 arg1Of peroxidase,(
R11335 T14593 T14605 arg1Of peroxidase,for
R11336 T14595 T14594 arg2Of HRP,(
R11337 T14596 T14594 arg3Of ),(
R11338 T14599 T14597 arg2Of AS,from
R11339 T14599 T14598 arg1Of AS,Dakocytomation
R11340 T14601 T14600 arg2Of Copenhagen,(
R11341 T14601 T14602 arg1Of Copenhagen,","
R11342 T14603 T14602 arg2Of Denmark,","
R11343 T14604 T14600 arg3Of ),(
R11344 T14607 T14605 arg2Of analysis,for
R11345 T14607 T14606 arg1Of analysis,immunoblot
R11346 T14608 T14609 arg1Of Anti-β-actin,was
R11347 T14608 T14610 arg1Of Anti-β-actin,from
R11348 T14609 T14626 arg1Of was,anti-CD19-FITC
R11349 T14610 T14609 arg2Of from,was
R11350 T14614 T14610 arg2Of Dickinson,from
R11351 T14614 T14611 arg1Of Dickinson,Santa-Cruz.
R11352 T14614 T14612 arg1Of Dickinson,From
R11353 T14614 T14613 arg1Of Dickinson,Becton
R11354 T14614 T14615 arg1Of Dickinson,(
R11355 T14614 T14623 arg2Of Dickinson,purchased
R11356 T14617 T14615 arg2Of Jose,(
R11357 T14617 T14616 arg1Of Jose,San
R11358 T14617 T14618 arg1Of Jose,","
R11359 T14619 T14618 arg2Of CA,","
R11360 T14620 T14615 arg3Of ),(
R11361 T14622 T14623 arg1Of we,purchased
R11362 T14623 T14621 arg1Of purchased,","
R11363 T14626 T14624 arg1Of anti-CD19-FITC,anti-CD19-PE
R11364 T14626 T14625 arg1Of anti-CD19-FITC,","
R11365 T14628 T14627 arg1Of antibodies,The
R11366 T14628 T14629 arg2Of antibodies,used
R11367 T14628 T14633 arg1Of antibodies,were
R11368 T14629 T14630 arg1Of used,for
R11369 T14632 T14630 arg2Of sorting,for
R11370 T14632 T14631 arg1Of sorting,cell
R11371 T14635 T14634 arg1Of PC5,anti-CD19
R11372 T14635 T14636 arg1Of PC5,from
R11373 T14635 T14639 arg1Of PC5,(
R11374 T14635 T14644 arg1Of PC5,and
R11375 T14638 T14636 arg2Of SA,from
R11376 T14638 T14637 arg1Of SA,Immunotech
R11377 T14640 T14639 arg2Of Marseille,(
R11378 T14640 T14641 arg1Of Marseille,","
R11379 T14642 T14641 arg2Of France,","
R11380 T14643 T14639 arg3Of ),(
R11381 T14644 T14633 arg2Of and,were
R11382 T14646 T14644 arg2Of PE,and
R11383 T14646 T14645 arg1Of PE,anti-CD27
R11384 T14646 T14647 arg1Of PE,from
R11385 T14649 T14647 arg2Of Dickinson,from
R11386 T14649 T14648 arg1Of Dickinson,Becton
R11387 T14649 T14650 arg1Of Dickinson,","
R11388 T14652 T14650 arg2Of Pharmingen,","
R11389 T14652 T14651 arg1Of Pharmingen,Biosciences
R11390 T14652 T14653 arg1Of Pharmingen,(
R11391 T14655 T14653 arg2Of Diego,(
R11392 T14655 T14654 arg1Of Diego,San
R11393 T14655 T14656 arg1Of Diego,","
R11394 T14657 T14656 arg2Of CA,","
R11395 T14657 T14658 arg1Of CA,","
R11396 T14659 T14658 arg2Of USA,","
R11397 T14660 T14653 arg3Of ),(
R11658 T15103 T15102 arg1Of sorting,Cell
R11659 T15105 T15104 arg1Of purified,Highly
R11660 T15106 T15107 arg1Of CD19+CD27-,or
R11661 T15108 T15107 arg2Of CD19+CD27+,or
R11662 T15109 T15105 arg1Of cells,purified
R11663 T15109 T15106 arg1Of cells,CD19+CD27-
R11664 T15109 T15108 arg1Of cells,CD19+CD27+
R11665 T15109 T15110 arg1Of cells,were
R11666 T15109 T15111 arg2Of cells,obtained
R11667 T15111 T15110 arg2Of obtained,were
R11668 T15111 T15112 arg1Of obtained,by
R11669 T15111 T15128 arg1Of obtained,","
R11670 T15111 T15129 modOf obtained,followed
R11671 T15113 T15112 arg2Of staining,by
R11672 T15113 T15116 arg1Of staining,with
R11673 T15115 T15113 arg2Of cells,staining
R11674 T15115 T15114 arg1Of cells,CD19+
R11675 T15118 T15119 arg1Of PE,and
R11676 T15120 T15119 arg2Of CD19,and
R11677 T15122 T15116 arg2Of mAbs,with
R11678 T15122 T15117 arg1Of mAbs,anti-CD27
R11679 T15122 T15118 arg1Of mAbs,PE
R11680 T15122 T15120 arg1Of mAbs,CD19
R11681 T15122 T15121 arg1Of mAbs,PC5
R11682 T15122 T15123 arg1Of mAbs,for
R11683 T15125 T15123 arg2Of minutes,for
R11684 T15125 T15124 arg1Of minutes,30
R11685 T15125 T15126 arg1Of minutes,at
R11686 T15127 T15126 arg2Of 4°C,at
R11687 T15129 T15130 arg1Of followed,by
R11688 T15131 T15132 arg1Of washing,with
R11689 T15131 T15134 arg1Of washing,and
R11690 T15133 T15132 arg2Of PBS,with
R11691 T15134 T15130 arg2Of and,by
R11692 T15135 T15134 arg2Of sorting,and
R11693 T15135 T15136 arg1Of sorting,on
R11694 T15138 T15136 arg2Of DiVa,on
R11695 T15138 T15137 arg1Of DiVa,FACS
R11696 T15138 T15139 arg1Of DiVa,from
R11697 T15141 T15139 arg2Of Dickinson,from
R11698 T15141 T15140 arg1Of Dickinson,Becton
R11752 T15270 T15269 arg1Of analysis,Western-blot
R11753 T15272 T15271 arg1Of cells,B
R11754 T15272 T15273 arg1Of cells,from
R11755 T15272 T15279 arg1Of cells,were
R11756 T15272 T15280 arg2Of cells,lysed
R11757 T15275 T15274 arg1Of blood,peripheral
R11758 T15275 T15276 arg1Of blood,or
R11759 T15276 T15273 arg2Of or,from
R11760 T15278 T15276 arg2Of cell-lines,or
R11761 T15278 T15277 arg2Of cell-lines,cultured
R11762 T15280 T15279 arg2Of lysed,were
R11763 T15280 T15281 arg1Of lysed,in
R11764 T15283 T15281 arg2Of buffer,in
R11765 T15283 T15282 arg1Of buffer,lysis
R11766 T15283 T15284 arg1Of buffer,(
R11767 T15287 T15285 arg1Of %,glycerol
R11768 T15287 T15286 arg1Of %,10
R11769 T15287 T15288 arg1Of %,","
R11770 T15288 T15292 arg1Of ",",","
R11771 T15291 T15288 arg2Of %,","
R11772 T15291 T15289 arg1Of %,β-mercaptoethanol
R11773 T15291 T15290 arg1Of %,5
R11774 T15292 T15300 arg1Of ",",","
R11775 T15293 T15294 arg1Of 0.0625,M
R11776 T15295 T15292 arg2Of Tris-HCL,","
R11777 T15295 T15293 arg1Of Tris-HCL,0.0625
R11778 T15295 T15296 arg1Of Tris-HCL,[
R11779 T15297 T15296 arg2Of pH,[
R11780 T15297 T15298 arg1Of pH,6.8
R11781 T15299 T15296 arg3Of ],[
R11782 T15300 T15284 arg2Of ",",(
R11783 T15305 T15304 arg2Of SDS,[
R11784 T15306 T15304 arg3Of ],[
R11785 T15307 T15308 arg1Of 2.5,%
R11786 T15309 T15300 arg2Of w/vol,","
R11787 T15309 T15301 arg1Of w/vol,sodium
R11788 T15309 T15302 arg1Of w/vol,dodecyl
R11789 T15309 T15303 arg1Of w/vol,sulphate
R11790 T15309 T15304 arg1Of w/vol,[
R11791 T15309 T15307 arg1Of w/vol,2.5
R11792 T15310 T15284 arg3Of ),(
R11793 T15312 T15311 arg1Of protein,Total
R11794 T15312 T15313 arg1Of protein,(
R11795 T15312 T15317 arg1Of protein,from
R11796 T15312 T15320 arg1Of protein,was
R11797 T15312 T15321 arg2Of protein,run
R11798 T15312 T15334 arg1Of protein,blotted
R11799 T15315 T15313 arg2Of μg,(
R11800 T15315 T15314 arg1Of μg,30–100
R11801 T15316 T15313 arg3Of ),(
R11802 T15319 T15317 arg2Of sample,from
R11803 T15319 T15318 arg1Of sample,each
R11804 T15321 T15320 arg2Of run,was
R11805 T15321 T15322 arg1Of run,on
R11806 T15321 T15333 arg1Of run,and
R11807 T15324 T15323 arg1Of %,10
R11808 T15324 T15325 arg1Of %,or
R11809 T15325 T15327 arg1Of or,%
R11810 T15326 T15325 arg2Of 12,or
R11811 T15330 T15329 arg2Of SDS/PAGE,(
R11812 T15331 T15329 arg3Of ),(
R11813 T15332 T15322 arg2Of gels,on
R11814 T15332 T15324 arg1Of gels,%
R11815 T15332 T15326 arg1Of gels,12
R11816 T15332 T15328 arg1Of gels,SDS/polyacrylamide
R11817 T15332 T15329 arg1Of gels,(
R11818 T15333 T15338 arg1Of and,(
R11819 T15334 T15333 arg2Of blotted,and
R11820 T15334 T15335 arg1Of blotted,onto
R11821 T15337 T15335 arg2Of filters,onto
R11822 T15337 T15336 arg1Of filters,nitrocellulose
R11823 T15339 T15340 arg1Of Protran,;
R11824 T15340 T15338 arg2Of ;,(
R11825 T15344 T15340 arg2Of GmbH,;
R11826 T15344 T15341 arg1Of GmbH,Schleicher
R11827 T15344 T15342 arg1Of GmbH,&
R11828 T15344 T15343 arg1Of GmbH,Schuell
R11829 T15344 T15345 arg1Of GmbH,","
R11830 T15346 T15345 arg2Of Dassel,","
R11831 T15346 T15347 arg1Of Dassel,","
R11832 T15348 T15347 arg2Of Germany,","
R11833 T15349 T15338 arg3Of ),(
R11834 T15350 T15351 arg1Of Blocking,","
R11835 T15351 T15353 arg1Of ",",and
R11836 T15352 T15351 arg2Of washing,","
R11837 T15353 T15355 arg1Of and,of
R11838 T15353 T15361 arg1Of and,were
R11839 T15353 T15362 arg2Of and,done
R11840 T15354 T15353 arg2Of incubation,and
R11841 T15357 T15355 arg2Of filters,of
R11842 T15357 T15356 arg1Of filters,the
R11843 T15357 T15358 arg1Of filters,with
R11844 T15360 T15358 arg2Of antibodies,with
R11845 T15360 T15359 arg1Of antibodies,primary
R11846 T15362 T15361 arg2Of done,were
R11847 T15362 T15363 arg1Of done,according
R11848 T15362 T15369 arg1Of done,at
R11849 T15364 T15363 arg2Of to,according
R11850 T15366 T15365 arg1Of manufacturer,the
R11851 T15366 T15367 arg2Of manufacturer,'s
R11852 T15368 T15364 arg2Of protocols,to
R11853 T15368 T15367 arg1Of protocols,'s
R11854 T15371 T15369 arg2Of temperature,at
R11855 T15371 T15370 arg1Of temperature,room
R11856 T15371 T15372 arg1Of temperature,(
R11857 T15373 T15372 arg2Of RT,(
R11858 T15374 T15372 arg3Of ),(
R11859 T15376 T15375 arg2Of washing,After
R11860 T15376 T15377 arg1Of washing,with
R11861 T15379 T15377 arg2Of %,with
R11862 T15379 T15378 arg1Of %,TBS/0.1
R11863 T15379 T15380 arg1Of %,Tween-20
R11864 T15379 T15381 arg1Of %,(
R11865 T15382 T15381 arg2Of TBS-T,(
R11866 T15383 T15381 arg3Of ),(
R11867 T15386 T15385 arg1Of filters,the
R11868 T15386 T15387 arg1Of filters,were
R11869 T15386 T15388 arg2Of filters,incubated
R11870 T15388 T15376 arg2Of incubated,washing
R11871 T15388 T15384 arg1Of incubated,","
R11872 T15388 T15387 arg2Of incubated,were
R11873 T15388 T15389 arg1Of incubated,with
R11874 T15391 T15389 arg2Of peroxidase,with
R11875 T15391 T15390 arg1Of peroxidase,horseradish
R11876 T15391 T15392 arg1Of peroxidase,(
R11877 T15391 T15395 arg2Of peroxidase,coupled
R11878 T15393 T15392 arg2Of HRP,(
R11879 T15394 T15392 arg3Of ),(
R11880 T15395 T15396 arg1Of coupled,to
R11881 T15399 T15396 arg2Of antibodies,to
R11882 T15399 T15397 arg1Of antibodies,relevant
R11883 T15399 T15398 arg1Of antibodies,secondary
R11884 T15401 T15375 arg1Of see,After
R11885 T15401 T15400 arg1Of see,(
R11886 T15401 T15402 arg1Of see,above
R11887 T15401 T15403 arg1Of see,)
R11888 T15401 T15404 arg1Of see,for
R11889 T15406 T15404 arg2Of minutes,for
R11890 T15406 T15405 arg1Of minutes,60
R11891 T15406 T15407 arg1Of minutes,at
R11892 T15408 T15401 arg2Of RT,see
R11893 T15410 T15409 arg1Of activity,Enzyme
R11894 T15410 T15411 arg1Of activity,was
R11895 T15410 T15412 arg2Of activity,visualised
R11896 T15412 T15411 arg2Of visualised,was
R11897 T15412 T15420 arg1Of visualised,(
R11898 T15417 T15412 arg1Of system,visualised
R11899 T15417 T15413 arg2Of system,by
R11900 T15417 T15414 arg1Of system,the
R11901 T15417 T15415 arg2Of system,enhanced
R11902 T15417 T15416 arg1Of system,chemiluminescence
R11903 T15417 T15418 arg1Of system,","
R11904 T15419 T15418 arg2Of ECL+PLUS,","
R11905 T15421 T15422 arg1Of Amersham,","
R11906 T15422 T15420 arg2Of ",",(
R11907 T15422 T15424 arg1Of ",",","
R11908 T15423 T15422 arg2Of Buckinghamshire,","
R11909 T15425 T15424 arg2Of UK,","
R11910 T15426 T15420 arg3Of ),(
R11911 T15428 T15427 arg1Of analysis,Densitometric
R11912 T15428 T15429 arg1Of analysis,was
R11913 T15428 T15430 arg2Of analysis,performed
R11914 T15430 T15429 arg2Of performed,was
R11915 T15433 T15430 arg1Of hyperfilms,performed
R11916 T15433 T15431 arg2Of hyperfilms,by
R11917 T15433 T15432 arg1Of hyperfilms,scanning
R11918 T15433 T15434 arg1Of hyperfilms,on
R11919 T15438 T15434 arg2Of SI,on
R11920 T15438 T15435 arg1Of SI,a
R11921 T15438 T15436 arg1Of SI,Personal
R11922 T15438 T15437 arg1Of SI,Densitometer
R11923 T15438 T15439 arg1Of SI,(
R11924 T15441 T15439 arg2Of Dynamics,(
R11925 T15441 T15440 arg1Of Dynamics,Molecular
R11926 T15441 T15442 arg1Of Dynamics,","
R11927 T15443 T15442 arg2Of Sunnyvale,","
R11928 T15443 T15444 arg1Of Sunnyvale,","
R11929 T15445 T15444 arg2Of CA,","
R11930 T15446 T15439 arg3Of ),(
R11931 T15447 T15448 arg1Of Quantification,of
R11932 T15447 T15455 arg1Of Quantification,was
R11933 T15447 T15456 arg2Of Quantification,calculated
R11934 T15449 T15450 arg1Of Id1,","
R11935 T15450 T15452 arg1Of ",",and
R11936 T15451 T15450 arg2Of Id2,","
R11937 T15453 T15452 arg2Of Id3,and
R11938 T15454 T15448 arg2Of protein,of
R11939 T15454 T15449 arg1Of protein,Id1
R11940 T15454 T15451 arg1Of protein,Id2
R11941 T15454 T15453 arg1Of protein,Id3
R11942 T15456 T15455 arg2Of calculated,was
R11943 T15456 T15457 arg1Of calculated,by
R11944 T15458 T15457 arg2Of normalizing,by
R11945 T15462 T15458 arg2Of bands,normalizing
R11946 T15462 T15459 arg1Of bands,the
R11947 T15462 T15460 arg1Of bands,specific
R11948 T15462 T15461 arg1Of bands,protein
R11949 T15462 T15463 arg1Of bands,to
R11950 T15462 T15465 arg1Of bands,using
R11951 T15464 T15463 arg2Of β-actin,to
R11952 T15469 T15465 arg2Of software,using
R11953 T15469 T15466 arg1Of software,Image
R11954 T15469 T15467 arg1Of software,Quant
R11955 T15469 T15468 arg1Of software,5.5
R11956 T15469 T15470 arg1Of software,(
R11957 T15472 T15470 arg2Of Dynamics,(
R11958 T15472 T15471 arg1Of Dynamics,Molecular
R11959 T15473 T15470 arg3Of ),(
R11992 T15608 T15609 arg1Of Analysis,of
R11993 T15612 T15609 arg2Of RNA,of
R11994 T15612 T15610 arg1Of RNA,BMP-6
R11995 T15612 T15611 arg1Of RNA,messenger
R11996 T15612 T15613 arg1Of RNA,(
R11997 T15614 T15613 arg2Of mRNA,(
R11998 T15615 T15613 arg3Of ),(
R11999 T15616 T15608 arg1Of expression,Analysis
R12000 T15618 T15617 arg1Of expression,Endogenous
R12001 T15618 T15619 arg1Of expression,of
R12002 T15618 T15623 arg1Of expression,was
R12003 T15618 T15624 arg2Of expression,examined
R12004 T15622 T15619 arg2Of gene,of
R12005 T15622 T15620 arg1Of gene,the
R12006 T15622 T15621 arg1Of gene,BMP-6
R12007 T15624 T15623 arg2Of examined,was
R12008 T15629 T15624 arg1Of reaction,examined
R12009 T15629 T15625 arg2Of reaction,by
R12010 T15629 T15626 arg1Of reaction,reverse
R12011 T15629 T15627 arg1Of reaction,transcription-polymerase
R12012 T15629 T15628 arg1Of reaction,chain
R12013 T15631 T15630 arg1Of RNA,Total
R12014 T15631 T15632 arg1Of RNA,was
R12015 T15631 T15633 arg2Of RNA,isolated
R12016 T15633 T15632 arg2Of isolated,was
R12017 T15634 T15633 arg3Of using,isolated
R12018 T15634 T15635 arg1Of using,Absolutely
R12019 T15634 T15648 arg1Of using,according
R12020 T15638 T15636 arg1Of Miniprep,RNA™
R12021 T15638 T15637 arg1Of Miniprep,RT-PCR
R12022 T15639 T15634 arg2Of Kit,using
R12023 T15639 T15638 arg1Of Kit,Miniprep
R12024 T15639 T15640 arg1Of Kit,(
R12025 T15642 T15641 arg1Of Europe,Stratagene
R12026 T15642 T15643 arg1Of Europe,","
R12027 T15643 T15640 arg2Of ",",(
R12028 T15643 T15645 arg1Of ",",","
R12029 T15643 T15646 arg1Of ",",Netherland
R12030 T15644 T15643 arg2Of Amsterdam,","
R12031 T15647 T15640 arg3Of ),(
R12032 T15649 T15648 arg2Of to,according
R12033 T15652 T15649 arg2Of instructions,to
R12034 T15652 T15650 arg1Of instructions,the
R12035 T15652 T15651 arg1Of instructions,manufacturers
R12036 T15653 T15654 arg1Of Quantification,of
R12037 T15653 T15659 arg1Of Quantification,was
R12038 T15653 T15660 arg2Of Quantification,achieved
R12039 T15658 T15654 arg2Of RNA,of
R12040 T15658 T15655 arg1Of RNA,the
R12041 T15658 T15656 arg2Of RNA,isolated
R12042 T15658 T15657 arg1Of RNA,total
R12043 T15660 T15659 arg2Of achieved,was
R12044 T15660 T15661 arg1Of achieved,by
R12045 T15662 T15661 arg2Of using,by
R12046 T15665 T15662 arg2Of measurements,using
R12047 T15665 T15663 arg1Of measurements,spectrophotometric
R12048 T15665 T15664 arg1Of measurements,OD260
R12049 T15667 T15666 arg1Of amounts,Equal
R12050 T15667 T15668 arg1Of amounts,of
R12051 T15667 T15670 arg1Of amounts,were
R12052 T15669 T15668 arg2Of RNA,of
R12053 T15670 T15671 arg1Of were,then
R12054 T15672 T15670 arg2Of reverse,were
R12055 T15672 T15673 modOf reverse,transcribed
R12056 T15673 T15674 arg1Of transcribed,to
R12057 T15675 T15674 arg2Of cDNA,to
R12058 T15675 T15676 arg1Of cDNA,with
R12059 T15678 T15677 arg1Of Reverse,TaqMan®
R12060 T15680 T15676 arg2Of Reagents,with
R12061 T15680 T15678 arg1Of Reagents,Reverse
R12062 T15680 T15679 arg1Of Reagents,Transcription
R12063 T15680 T15681 arg1Of Reagents,(
R12064 T15683 T15682 arg1Of Biosystems,Applied
R12065 T15683 T15684 arg1Of Biosystems,","
R12066 T15684 T15687 arg1Of ",",","
R12067 T15686 T15684 arg2Of City,","
R12068 T15686 T15685 arg1Of City,Foster
R12069 T15687 T15681 arg2Of ",",(
R12070 T15687 T15689 arg1Of ",",","
R12071 T15688 T15687 arg2Of CA,","
R12072 T15690 T15689 arg2Of U.S.A,","
R12073 T15691 T15681 arg3Of ),(
R12074 T15693 T15692 arg1Of measure,To
R12075 T15695 T15693 arg2Of expression,measure
R12076 T15695 T15694 arg1Of expression,mRNA
R12077 T15695 T15696 arg1Of expression,of
R12078 T15697 T15696 arg2Of BMP6,of
R12079 T15699 T15700 arg1Of Id1–Id4,and
R12080 T15701 T15700 arg2Of PGK1,and
R12081 T15702 T15693 arg1Of PCR,measure
R12082 T15702 T15699 arg1Of PCR,Id1–Id4
R12083 T15702 T15701 arg1Of PCR,PGK1
R12084 T15702 T15703 arg1Of PCR,were
R12085 T15702 T15704 arg2Of PCR,carried
R12086 T15704 T15692 modOf carried,To
R12087 T15704 T15698 arg1Of carried,","
R12088 T15704 T15703 arg2Of carried,were
R12089 T15704 T15705 arg1Of carried,out
R12090 T15704 T15706 arg1Of carried,with
R12091 T15710 T15706 arg2Of mix,with
R12092 T15710 T15707 arg1Of mix,TaqMan®
R12093 T15710 T15708 arg1Of mix,universal
R12094 T15710 T15709 arg1Of mix,master
R12095 T15711 T15712 arg1Of Primers,and
R12096 T15712 T15714 arg1Of and,were
R12097 T15712 T15715 arg2Of and,provided
R12098 T15713 T15712 arg2Of probes,and
R12099 T15715 T15714 arg2Of provided,were
R12100 T15717 T15715 arg1Of Assay-on-Demand,provided
R12101 T15717 T15716 arg2Of Assay-on-Demand,by
R12102 T15717 T15718 arg1Of Assay-on-Demand,(
R12103 T15720 T15718 arg2Of Biosystems,(
R12104 T15720 T15719 arg1Of Biosystems,Applied
R12105 T15721 T15718 arg3Of ),(
R12106 T15723 T15722 arg1Of reactions,PCR
R12107 T15723 T15724 arg1Of reactions,were
R12108 T15723 T15725 arg2Of reactions,carried
R12109 T15725 T15724 arg2Of carried,were
R12110 T15725 T15726 arg1Of carried,out
R12111 T15725 T15727 arg1Of carried,in
R12112 T15730 T15727 arg2Of volume,in
R12113 T15730 T15728 arg1Of volume,a
R12114 T15730 T15729 arg1Of volume,final
R12115 T15730 T15731 arg1Of volume,of
R12116 T15733 T15732 arg1Of μl,25
R12117 T15733 T15734 arg1Of μl,(
R12118 T15733 T15737 arg1Of μl,or
R12119 T15735 T15734 arg2Of BMP-6,(
R12120 T15736 T15734 arg3Of ),(
R12121 T15737 T15731 arg2Of or,of
R12122 T15739 T15737 arg2Of μl,or
R12123 T15739 T15738 arg1Of μl,20
R12124 T15739 T15740 arg1Of μl,(
R12125 T15741 T15740 arg2Of ID1,(
R12126 T15742 T15740 arg3Of ),(
R12127 T15744 T15743 arg1Of cDNA,The
R12128 T15744 T15745 arg2Of cDNA,added
R12129 T15744 T15749 arg1Of cDNA,was
R12130 T15744 T15750 arg1Of cDNA,equivalent
R12131 T15745 T15746 arg1Of added,to
R12132 T15748 T15746 arg2Of reaction,to
R12133 T15748 T15747 arg1Of reaction,each
R12134 T15750 T15749 arg2Of equivalent,was
R12135 T15750 T15751 arg1Of equivalent,to
R12136 T15753 T15751 arg2Of input,to
R12137 T15753 T15752 arg1Of input,the
R12138 T15753 T15754 arg1Of input,of
R12139 T15756 T15754 arg2Of ng,of
R12140 T15756 T15755 arg1Of ng,20
R12141 T15756 T15757 arg1Of ng,of
R12142 T15759 T15757 arg2Of RNA,of
R12143 T15759 T15758 arg1Of RNA,total
R12144 T15762 T15760 arg1Of expression,The
R12145 T15762 T15761 arg1Of expression,gene
R12146 T15762 T15763 arg1Of expression,was
R12147 T15762 T15764 arg2Of expression,quantified
R12148 T15762 T15765 arg1Of expression,using
R12149 T15764 T15763 arg2Of quantified,was
R12150 T15765 T15764 arg3Of using,quantified
R12151 T15765 T15782 arg1Of using,as
R12152 T15769 T15766 arg1Of method,the
R12153 T15769 T15767 arg1Of method,standard
R12154 T15769 T15768 arg1Of method,curve
R12155 T15769 T15770 arg1Of method,(
R12156 T15769 T15774 arg1Of method,or
R12157 T15771 T15770 arg2Of BMP6,(
R12158 T15772 T15770 arg3Of ),(
R12159 T15774 T15765 arg2Of or,using
R12160 T15774 T15773 arg1Of or,","
R12161 T15778 T15774 arg2Of method,or
R12162 T15778 T15775 arg1Of method,the
R12163 T15778 T15776 arg1Of method,comparative
R12164 T15778 T15777 arg1Of method,CT
R12165 T15778 T15779 arg1Of method,(
R12166 T15780 T15779 arg2Of Id1,(
R12167 T15781 T15779 arg3Of ),(
R12168 T15783 T15782 arg2Of described,as
R12169 T15783 T15784 arg1Of described,in
R12170 T15787 T15784 arg2Of Bulletin,in
R12171 T15787 T15785 arg1Of Bulletin,ABI7700
R12172 T15787 T15786 arg1Of Bulletin,User
R12173 T15787 T15788 arg1Of Bulletin,2
R12174 T15787 T15789 arg1Of Bulletin,(
R12175 T15791 T15789 arg2Of Biosystems,(
R12176 T15791 T15790 arg1Of Biosystems,Applied
R12177 T15792 T15789 arg3Of ),(
R12178 T15794 T15793 arg1Of expression,The
R12179 T15794 T15795 arg1Of expression,was
R12180 T15794 T15797 arg2Of expression,normalized
R12181 T15797 T15795 arg2Of normalized,was
R12182 T15797 T15796 arg1Of normalized,then
R12183 T15797 T15798 arg1Of normalized,to
R12184 T15801 T15798 arg2Of level,to
R12185 T15801 T15799 arg1Of level,the
R12186 T15801 T15800 arg1Of level,expression
R12187 T15801 T15802 arg1Of level,of
R12188 T15803 T15802 arg2Of PGK1,of
R12189 T15804 T15805 arg1Of PGK1,was
R12190 T15804 T15806 arg2Of PGK1,chosen
R12191 T15806 T15805 arg2Of chosen,was
R12192 T15806 T15807 arg1Of chosen,","
R12193 T15806 T15808 arg1Of chosen,because
R12194 T15809 T15810 arg1Of it,has
R12195 T15809 T15811 arg1Of it,been
R12196 T15809 T15812 arg2Of it,shown
R12197 T15809 T15814 arg1Of it,have
R12198 T15812 T15808 arg2Of shown,because
R12199 T15812 T15810 arg2Of shown,has
R12200 T15812 T15811 arg2Of shown,been
R12201 T15812 T15821 arg1Of shown,[
R12202 T15814 T15812 arg3Of have,shown
R12203 T15814 T15813 arg1Of have,to
R12204 T15817 T15814 arg2Of variability,have
R12205 T15817 T15815 arg1Of variability,low
R12206 T15817 T15816 arg1Of variability,expression
R12207 T15817 T15818 arg1Of variability,among
R12208 T15820 T15818 arg2Of specimens,among
R12209 T15820 T15819 arg1Of specimens,lymphocyte
R12210 T15822 T15821 arg2Of 56,[
R12211 T15823 T15821 arg3Of ],[
R12212 T15825 T15824 arg1Of levels,Expression
R12213 T15825 T15826 arg1Of levels,in
R12214 T15825 T15829 arg1Of levels,were
R12215 T15825 T15831 arg2Of levels,related
R12216 T15828 T15826 arg2Of cells,in
R12217 T15828 T15827 arg1Of cells,B
R12218 T15831 T15829 arg2Of related,were
R12219 T15831 T15830 arg1Of related,then
R12220 T15831 T15832 arg1Of related,to
R12221 T15835 T15832 arg2Of levels,to
R12222 T15835 T15833 arg1Of levels,the
R12223 T15835 T15834 arg1Of levels,expression
R12224 T15835 T15836 arg1Of levels,in
R12225 T15838 T15836 arg2Of cells,in
R12226 T15838 T15837 arg1Of cells,Ramos
R12526 T16238 T16237 arg1Of proliferation,Cell
R12528 T16240 T16239 arg2Of estimation,For
R12533 T16246 T16254 arg1Of cells,or
R12534 T16248 T16249 arg1Of 7.5,×
R12535 T16250 T16249 arg2Of 104,×
R12537 T16252 T16248 arg1Of ml,7.5
R12538 T16252 T16250 arg1Of ml,104
R12539 T16252 T16251 arg1Of ml,cells/0.2
R12540 T16253 T16247 arg3Of ),(
R12541 T16254 T16264 arg1Of or,were
R12542 T16254 T16265 arg2Of or,cultured
R12543 T16256 T16254 arg2Of cells,or
R12544 T16256 T16255 arg1Of cells,Ramos
R12545 T16256 T16257 arg1Of cells,(
R12546 T16262 T16257 arg2Of ml,(
R12547 T16262 T16258 arg1Of ml,1
R12548 T16262 T16259 arg1Of ml,×
R12549 T16262 T16260 arg1Of ml,104
R12550 T16262 T16261 arg1Of ml,cells/0.2
R12551 T16263 T16257 arg3Of ),(
R12553 T16265 T16239 arg1Of cultured,For
R12554 T16265 T16264 arg2Of cultured,were
R12555 T16265 T16266 arg1Of cultured,in
R12556 T16267 T16266 arg2Of triplicate,in
R12557 T16267 T16268 arg1Of triplicate,in
R12558 T16270 T16268 arg2Of wells,in
R12559 T16270 T16269 arg1Of wells,microtiter
R12560 T16272 T16271 arg1Of cells,The
R12561 T16272 T16273 arg1Of cells,were
R12562 T16272 T16274 arg2Of cells,pulsed
R12563 T16274 T16273 arg2Of pulsed,were
R12564 T16274 T16275 arg1Of pulsed,with
R12565 T16276 T16277 arg1Of 3.7,×
R12566 T16277 T16275 arg2Of ×,with
R12567 T16280 T16279 arg2Of 3H,[
R12568 T16281 T16279 arg3Of ],[
R12569 T16282 T16277 arg2Of thymidine,×
R12570 T16282 T16278 arg1Of thymidine,104Bq
R12571 T16282 T16279 arg1Of thymidine,[
R12572 T16282 T16283 arg1Of thymidine,(
R12573 T16282 T16290 arg1Of thymidine,for
R12574 T16284 T16285 arg1Of Amersham,","
R12575 T16285 T16283 arg2Of ",",(
R12576 T16285 T16287 arg1Of ",",","
R12577 T16286 T16285 arg2Of Buckinghamshire,","
R12578 T16288 T16287 arg2Of UK,","
R12579 T16289 T16283 arg3Of ),(
R12580 T16294 T16290 arg2Of h,for
R12581 T16294 T16291 arg1Of h,the
R12582 T16294 T16292 arg1Of h,last
R12583 T16294 T16293 arg1Of h,16
R12584 T16294 T16295 arg1Of h,of
R12585 T16298 T16295 arg2Of incubation,of
R12586 T16298 T16296 arg1Of incubation,a
R12587 T16298 T16297 arg1Of incubation,72-h
R12588 T16300 T16299 arg1Of cells,The
R12589 T16300 T16301 arg1Of cells,were
R12590 T16300 T16302 arg2Of cells,harvested
R12591 T16302 T16301 arg2Of harvested,were
R12592 T16302 T16319 arg1Of harvested,and
R12593 T16303 T16302 arg3Of using,harvested
R12594 T16303 T16308 arg1Of using,(
R12595 T16307 T16303 arg2Of harvester,using
R12596 T16307 T16304 arg1Of harvester,an
R12597 T16307 T16305 arg2Of harvester,automated
R12598 T16307 T16306 arg1Of harvester,cell
R12599 T16311 T16308 arg2Of Company,(
R12600 T16311 T16309 arg1Of Company,Packard
R12601 T16311 T16310 arg1Of Company,Instrument
R12602 T16311 T16312 arg1Of Company,","
R12603 T16311 T16316 arg1Of Company,","
R12604 T16311 T16317 arg1Of Company,USA
R12605 T16313 T16314 arg1Of Meriden,","
R12606 T16314 T16312 arg2Of ",",","
R12607 T16315 T16314 arg2Of CT,","
R12608 T16318 T16308 arg3Of ),(
R12609 T16321 T16320 arg2Of 3H,[
R12610 T16322 T16320 arg3Of ],[
R12611 T16324 T16320 arg1Of incorporation,[
R12612 T16324 T16323 arg1Of incorporation,thymidine
R12613 T16324 T16325 arg1Of incorporation,was
R12614 T16324 T16326 arg2Of incorporation,determined
R12615 T16326 T16319 arg2Of determined,and
R12616 T16326 T16325 arg2Of determined,was
R12617 T16326 T16327 arg1Of determined,in
R12618 T16326 T16331 arg1Of determined,(
R12619 T16330 T16327 arg2Of counter,in
R12620 T16330 T16328 arg1Of counter,a
R12621 T16330 T16329 arg1Of counter,scintillation
R12622 T16332 T16333 arg1Of TopCount,","
R12623 T16333 T16338 arg1Of ",",","
R12624 T16337 T16333 arg2Of Inc.,","
R12625 T16337 T16334 arg1Of Inc.,Packard
R12626 T16337 T16335 arg1Of Inc.,Instrument
R12627 T16337 T16336 arg1Of Inc.,Company
R12628 T16338 T16331 arg2Of ",",(
R12629 T16338 T16340 arg1Of ",",","
R12630 T16339 T16338 arg2Of Meriden,","
R12631 T16341 T16340 arg2Of CT,","
R12632 T16342 T16331 arg3Of ),(
R12745 T16481 T16482 arg1Of Determination,of
R12746 T16484 T16482 arg2Of death,of
R12747 T16484 T16483 arg1Of death,cell
R12748 T16486 T16485 arg1Of death,Cell
R12749 T16486 T16487 arg1Of death,was
R12750 T16486 T16488 arg2Of death,measured
R12751 T16486 T16495 arg1Of death,staining
R12752 T16488 T16487 arg2Of measured,was
R12753 T16488 T16494 arg1Of measured,by
R12754 T16488 T16518 arg1Of measured,for
R12755 T16493 T16488 arg1Of test,measured
R12756 T16493 T16489 arg2Of test,by
R12757 T16493 T16490 arg1Of test,vital
R12758 T16493 T16491 arg1Of test,dye
R12759 T16493 T16492 arg1Of test,exclusion
R12760 T16495 T16494 arg2Of staining,by
R12761 T16495 T16497 arg1Of staining,with
R12762 T16496 T16495 arg2Of cells,staining
R12763 T16501 T16497 arg2Of iodide,with
R12764 T16501 T16498 arg1Of iodide,5
R12765 T16501 T16499 arg1Of iodide,μg/ml
R12766 T16501 T16500 arg1Of iodide,propidium
R12767 T16501 T16502 arg1Of iodide,(
R12768 T16504 T16503 arg2Of PI,[
R12769 T16504 T16506 arg1Of PI,;
R12770 T16505 T16503 arg3Of ],[
R12771 T16506 T16509 arg1Of ;,;
R12772 T16508 T16506 arg2Of Corp.,;
R12773 T16508 T16507 arg1Of Corp.,Calbiochem
R12774 T16509 T16514 arg1Of ;,;
R12775 T16511 T16509 arg2Of Jolla,;
R12776 T16511 T16510 arg1Of Jolla,La
R12777 T16511 T16512 arg1Of Jolla,","
R12778 T16513 T16512 arg2Of CA,","
R12779 T16514 T16502 arg2Of ;,(
R12780 T16516 T16514 arg2Of mg/ml,;
R12781 T16516 T16515 arg1Of mg/ml,5
R12782 T16517 T16502 arg3Of ),(
R12783 T16520 T16518 arg2Of minute,for
R12784 T16520 T16519 arg1Of minute,one
R12785 T16520 T16521 arg1Of minute,on
R12786 T16522 T16521 arg2Of ice,on
R12787 T16525 T16523 arg1Of "1,000",At
R12788 T16525 T16524 arg1Of "1,000",least
R12789 T16526 T16525 arg1Of cells,"1,000"
R12790 T16526 T16527 arg1Of cells,per
R12791 T16526 T16529 arg1Of cells,were
R12792 T16526 T16530 arg2Of cells,run
R12793 T16528 T16527 arg2Of sample,per
R12794 T16530 T16529 arg2Of run,were
R12795 T16530 T16531 arg1Of run,on
R12796 T16536 T16531 arg2Of cytometer,on
R12797 T16536 T16532 arg1Of cytometer,a
R12798 T16536 T16533 arg1Of cytometer,BD
R12799 T16536 T16534 arg1Of cytometer,FACSCalibur
R12800 T16536 T16535 arg1Of cytometer,flow
R12861 T16610 T16609 arg1Of analysis,Statistical
R12862 T16613 T16611 arg1Of significance,The
R12863 T16613 T16612 arg1Of significance,statistical
R12864 T16613 T16614 arg1Of significance,of
R12865 T16613 T16616 arg1Of significance,between
R12866 T16613 T16618 arg1Of significance,was
R12867 T16613 T16619 arg2Of significance,determined
R12868 T16613 T16629 arg1Of significance,applying
R12869 T16615 T16614 arg2Of differences,of
R12870 T16617 T16616 arg2Of groups,between
R12871 T16619 T16618 arg2Of determined,was
R12872 T16619 T16627 arg1Of determined,","
R12873 T16619 T16628 arg1Of determined,by
R12874 T16620 T16619 arg3Of using,determined
R12875 T16626 T16620 arg2Of test,using
R12876 T16626 T16621 arg1Of test,the
R12877 T16626 T16622 arg1Of test,paired
R12878 T16626 T16623 arg1Of test,two-tailed
R12879 T16626 T16624 arg1Of test,Wilcoxon
R12880 T16626 T16625 arg1Of test,nonparametric
R12881 T16629 T16628 arg2Of applying,by
R12882 T16631 T16629 arg2Of software,applying
R12883 T16631 T16630 arg1Of software,SPSS10.1
R12884 T16631 T16632 arg1Of software,(
R12885 T16634 T16632 arg2Of Inc.,(
R12886 T16634 T16633 arg1Of Inc.,SPSS
R12887 T16634 T16635 arg1Of Inc.,","
R12888 T16634 T16639 arg1Of Inc.,","
R12889 T16634 T16640 arg1Of Inc.,USA
R12890 T16636 T16637 arg1Of Chicago,","
R12891 T16637 T16635 arg2Of ",",","
R12892 T16638 T16637 arg2Of IL,","
R12893 T16641 T16632 arg3Of ),(
R12894 T16643 T16642 arg1Of values,P
R12895 T16643 T16644 arg1Of values,less
R12896 T16643 T16647 arg1Of values,were
R12897 T16643 T16648 arg2Of values,considered
R12898 T16643 T16649 arg1Of values,significant
R12899 T16644 T16645 arg1Of less,than
R12900 T16646 T16645 arg2Of 0.05,than
R12901 T16648 T16647 arg2Of considered,were
R12902 T16649 T16648 arg3Of significant,considered
R12527 T16240 T16241 arg1Of estimation,of
R12529 T16243 T16241 arg2Of synthesis,of
R12530 T16243 T16242 arg1Of synthesis,DNA
R12531 T16246 T16245 arg1Of cells,CD19+
R12532 T16246 T16247 arg1Of cells,(
R12536 T16252 T16247 arg2Of ml,(
R12552 T16265 T16244 arg1Of cultured,","
R849 T1148 T1149 arg1Of Members,of
R850 T1148 T1159 arg1Of Members,play
R851 T1148 T1163 arg1Of Members,controlling
R852 T1154 T1152 arg1Of β,growth
R853 T1154 T1153 arg1Of β,factor
R854 T1154 T1155 arg1Of β,(
R855 T1156 T1155 arg2Of TGF-β,(
R856 T1157 T1155 arg3Of ),(
R857 T1158 T1149 arg2Of superfamily,of
R858 T1158 T1150 arg1Of superfamily,the

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T9812 13723-13747 Antecedent denotes the BMP type I receptors
T9813 13773-13794 Antecedent denotes the type II-receptors
T9814 13847-13859 Anaphor denotes several BMPs
T9815 13871-13876 Antecedent denotes BMP-6
T9816 15789-15792 Anaphor denotes its
T9817 15685-15688 Antecedent denotes Id1
T9818 16323-16338 Anaphor denotes the Id proteins
T9819 16290-16293 Antecedent denotes Id2
T9820 16298-16301 Antecedent denotes Id3
T9821 16803-16817 Anaphor denotes these proteins
T9822 16766-16770 Antecedent denotes Pax5
T9823 16826-16830 Anaphor denotes them
T9824 17697-17714 Anaphor denotes the family member
T9825 17679-17682 Antecedent denotes Id1
T4827 7960-7964 Anaphor denotes Smad
T4828 7835-7840 Antecedent denotes Smad1
T4829 7841-7842 Antecedent denotes 5
T4830 7843-7844 Antecedent denotes 8
T1600 3332-3350 Anaphor denotes the receptor Smads
T1601 3352-3358 Antecedent denotes Smad-1
T1602 3360-3366 Antecedent denotes Smad-5
T1603 3372-3378 Antecedent denotes Smad-8
T1604 3381-3393 Anaphor denotes The R- Smads
T1605 3909-3925 Anaphor denotes the target genes
T1606 3926-3929 Antecedent denotes Id1
T1607 3930-3933 Antecedent denotes Id4
T15839 28267-28269 Anaphor denotes it
T15840 28242-28246 Antecedent denotes PGK1
T6715 11487-11505 Anaphor denotes the native protein
T6716 11465-11470 Antecedent denotes BMP-6
T9805 13723-13747 Anaphor denotes the BMP type I receptors
T9806 13748-13755 Antecedent denotes Act-RIA
T9807 13760-13767 Antecedent denotes BMP-RIB
T9808 13773-13794 Anaphor denotes the type II-receptors
T9809 13795-13802 Antecedent denotes BMP-RII
T9810 13807-13815 Antecedent denotes Act-RIIb
T9811 13817-13822 Anaphor denotes which
R7879 T9814 T9815 boundBy several BMPs,BMP-6
R7881 T9816 T9817 boundBy its,Id1
R7883 T9818 T9819 boundBy the Id proteins,Id2
R7884 T9818 T9820 boundBy the Id proteins,Id3
R7886 T9821 T9822 boundBy these proteins,Pax5
R7889 T9823 T9822 boundBy them,Pax5
R7890 T9824 T9825 boundBy the family member,Id1
R12227 T15839 T15840 boundBy it,PGK1
R1312 T1600 T1601 boundBy the receptor Smads,Smad-1
R1313 T1600 T1602 boundBy the receptor Smads,Smad-5
R1314 T1600 T1603 boundBy the receptor Smads,Smad-8
R1315 T1604 T1601 boundBy The R- Smads,Smad-1
R1316 T1604 T1602 boundBy The R- Smads,Smad-5
R1317 T1604 T1603 boundBy The R- Smads,Smad-8
R1318 T1605 T1606 boundBy the target genes,Id1
R1319 T1605 T1607 boundBy the target genes,Id4
R3770 T4827 T4828 boundBy Smad,Smad1
R3771 T4827 T4829 boundBy Smad,5
R3772 T4827 T4830 boundBy Smad,8
R5310 T6715 T6716 boundBy the native protein,BMP-6
R7870 T9805 T9806 boundBy the BMP type I receptors,Act-RIA
R7871 T9805 T9807 boundBy the BMP type I receptors,BMP-RIB
R7874 T9808 T9809 boundBy the type II-receptors,BMP-RII
R7875 T9808 T9810 boundBy the type II-receptors,Act-RIIb
R7876 T9811 T9805 boundBy which,the BMP type I receptors
R7877 T9811 T9808 boundBy which,the type II-receptors

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T5938 8961-8966 JJ denotes total
T502 0-5 CD denotes BMP-6
T503 6-14 NNS denotes inhibits
T504 15-21 NN denotes growth
T505 22-24 IN denotes of
T506 25-31 JJ denotes mature
T507 32-37 JJ denotes human
T508 38-39 NNP denotes B
T509 40-45 NNS denotes cells
T510 45-46 : denotes ;
T511 47-56 NN denotes induction
T512 57-59 IN denotes of
T513 60-64 NNP denotes Smad
T514 65-80 NN denotes phosphorylation
T515 81-84 CC denotes and
T516 85-97 NN denotes upregulation
T517 98-100 IN denotes of
T518 101-104 NNP denotes Id1
T519 116-126 NNP denotes Background
T520 127-131 NNP denotes Bone
T521 132-145 JJ denotes morphogenetic
T522 146-154 NNS denotes proteins
T523 155-156 -LRB- denotes (
T524 156-160 NNS denotes BMPs
T525 160-161 -RRB- denotes )
T526 162-168 VBP denotes belong
T527 169-171 TO denotes to
T528 172-175 DT denotes the
T529 176-181 NNP denotes TGF-β
T530 182-193 RB denotes superfamily
T531 194-197 CC denotes and
T532 198-201 VBP denotes are
T533 202-210 VBN denotes secreted
T534 211-219 NNS denotes proteins
T535 220-224 IN denotes with
T536 225-236 JJ denotes pleiotropic
T537 237-242 NNS denotes roles
T538 243-245 IN denotes in
T539 246-250 JJ denotes many
T540 251-260 JJ denotes different
T541 261-265 NN denotes cell
T542 266-271 NNS denotes types
T543 271-272 . denotes .
T544 273-274 DT denotes A
T545 275-284 JJ denotes potential
T546 285-289 NN denotes role
T547 290-292 IN denotes of
T548 293-298 NN denotes BMP-6
T549 299-301 IN denotes in
T550 302-305 DT denotes the
T551 306-312 JJ denotes immune
T552 313-319 NN denotes system
T553 320-323 VBZ denotes has
T554 324-328 VBN denotes been
T555 329-336 VBN denotes implied
T556 337-339 IN denotes by
T557 340-347 JJ denotes various
T558 348-355 NNS denotes studies
T559 356-358 IN denotes of
T560 359-368 JJ denotes malignant
T561 369-372 CC denotes and
T562 373-383 JJ denotes rheumatoid
T563 384-392 NNS denotes diseases
T564 392-393 . denotes .
T565 394-396 IN denotes In
T566 397-400 DT denotes the
T567 401-408 JJ denotes present
T568 409-414 NN denotes study
T569 414-415 , denotes ,
T570 416-418 PRP denotes we
T571 419-427 VBD denotes explored
T572 428-431 DT denotes the
T573 432-436 NN denotes role
T574 437-439 IN denotes of
T575 440-445 NN denotes BMP-6
T576 446-448 IN denotes in
T577 449-455 JJ denotes normal
T578 456-461 JJ denotes human
T579 462-472 JJ denotes peripheral
T580 473-478 NN denotes blood
T581 479-480 NNP denotes B
T582 481-486 NNS denotes cells
T583 486-487 . denotes .
T584 489-496 NNS denotes Results
T585 497-500 DT denotes The
T586 501-502 NNP denotes B
T587 503-508 NNS denotes cells
T588 509-513 VBD denotes were
T589 514-519 VBN denotes found
T590 520-522 TO denotes to
T591 523-530 VB denotes express
T592 531-534 NN denotes BMP
T593 535-539 NN denotes type
T594 540-541 PRP denotes I
T595 542-545 CC denotes and
T596 546-550 NN denotes type
T597 551-553 NNP denotes II
T598 554-563 NNS denotes receptors
T599 564-567 CC denotes and
T600 568-573 NN denotes BMP-6
T601 574-581 RB denotes rapidly
T602 582-589 VBD denotes induced
T603 590-605 NN denotes phosphorylation
T604 606-608 IN denotes of
T605 609-618 NNP denotes Smad1/5/8
T606 618-619 . denotes .
T607 620-631 RB denotes Furthermore
T608 631-632 , denotes ,
T609 633-653 NN denotes Smad-phosphorylation
T610 654-657 VBD denotes was
T611 658-666 VBN denotes followed
T612 667-669 IN denotes by
T613 670-682 NN denotes upregulation
T614 683-685 IN denotes of
T615 686-689 NNP denotes Id1
T616 690-694 NNP denotes mRNA
T617 695-698 CC denotes and
T618 699-702 NNP denotes Id1
T619 703-710 NN denotes protein
T620 710-711 , denotes ,
T621 712-719 IN denotes whereas
T622 720-723 NNP denotes Id2
T623 724-727 CC denotes and
T624 728-731 NNP denotes Id3
T625 732-742 NN denotes expression
T626 743-746 VBD denotes was
T627 747-750 RB denotes not
T628 751-759 VBN denotes affected
T629 759-760 . denotes .
T630 761-772 RB denotes Furthermore
T631 772-773 , denotes ,
T632 774-776 PRP denotes we
T633 777-782 VBD denotes found
T634 783-787 IN denotes that
T635 788-793 NNP denotes BMP-6
T636 794-797 VBD denotes had
T637 798-800 DT denotes an
T638 801-818 JJ denotes antiproliferative
T639 819-825 NN denotes effect
T640 826-830 DT denotes both
T641 831-833 IN denotes in
T642 834-839 NN denotes naïve
T643 840-841 -LRB- denotes (
T644 841-845 CD denotes CD19
T645 845-846 CD denotes +
T646 846-850 NNP denotes CD27
T647 850-851 : denotes -
T648 851-852 -RRB- denotes )
T649 853-856 CC denotes and
T650 857-863 NN denotes memory
T651 864-865 NNP denotes B
T652 866-871 NNS denotes cells
T653 872-873 -LRB- denotes (
T654 873-877 CD denotes CD19
T655 877-878 CD denotes +
T656 878-882 NNP denotes CD27
T657 882-883 NN denotes +
T658 883-884 -RRB- denotes )
T659 885-895 VBN denotes stimulated
T660 896-900 IN denotes with
T661 901-909 JJ denotes anti-IgM
T662 910-915 RB denotes alone
T663 916-918 CC denotes or
T664 919-922 DT denotes the
T665 923-931 VBN denotes combined
T666 932-938 NN denotes action
T667 939-941 IN denotes of
T668 942-950 JJ denotes anti-IgM
T669 951-954 CC denotes and
T670 955-960 NNP denotes CD40L
T671 960-961 . denotes .
T672 962-974 RB denotes Additionally
T673 974-975 , denotes ,
T674 976-981 NNP denotes BMP-6
T675 982-989 VBD denotes induced
T676 990-994 NN denotes cell
T677 995-1000 NN denotes death
T678 1001-1003 IN denotes in
T679 1004-1013 VBN denotes activated
T680 1014-1020 NN denotes memory
T681 1021-1022 NNP denotes B
T682 1023-1028 NNS denotes cells
T683 1028-1029 . denotes .
T684 1030-1041 RB denotes Importantly
T685 1041-1042 , denotes ,
T686 1043-1046 DT denotes the
T687 1047-1064 JJ denotes antiproliferative
T688 1065-1071 NN denotes effect
T689 1072-1074 IN denotes of
T690 1075-1080 NNP denotes BMP-6
T691 1081-1083 IN denotes in
T692 1084-1091 NNP denotes B-cells
T693 1092-1095 VBD denotes was
T694 1096-1106 RB denotes completely
T695 1107-1118 VBN denotes neutralized
T696 1119-1121 IN denotes by
T697 1122-1125 DT denotes the
T698 1126-1133 JJ denotes natural
T699 1134-1144 NN denotes antagonist
T700 1144-1145 , denotes ,
T701 1146-1152 NN denotes noggin
T702 1152-1153 . denotes .
T703 1154-1165 RB denotes Furthermore
T704 1165-1166 , denotes ,
T705 1167-1168 NNP denotes B
T706 1169-1174 NNS denotes cells
T707 1175-1179 VBD denotes were
T708 1180-1192 VBN denotes demonstrated
T709 1193-1195 TO denotes to
T710 1196-1206 VB denotes upregulate
T711 1207-1212 NNP denotes BMP-6
T712 1213-1217 NNP denotes mRNA
T713 1218-1222 IN denotes upon
T714 1223-1234 NN denotes stimulation
T715 1235-1239 IN denotes with
T716 1240-1248 JJ denotes anti-IgM
T717 1248-1249 . denotes .
T718 1251-1261 NN denotes Conclusion
T719 1262-1264 IN denotes In
T720 1265-1271 JJ denotes mature
T721 1272-1277 JJ denotes human
T722 1278-1279 NNP denotes B
T723 1280-1285 NNS denotes cells
T724 1285-1286 , denotes ,
T725 1287-1292 NNP denotes BMP-6
T726 1293-1302 VBD denotes inhibited
T727 1303-1307 NN denotes cell
T728 1308-1314 NN denotes growth
T729 1314-1315 , denotes ,
T730 1316-1319 CC denotes and
T731 1320-1327 RB denotes rapidly
T732 1328-1335 VBD denotes induced
T733 1336-1351 NN denotes phosphorylation
T734 1352-1354 IN denotes of
T735 1355-1364 JJ denotes Smad1/5/8
T736 1365-1373 VBN denotes followed
T737 1374-1376 IN denotes by
T738 1377-1379 DT denotes an
T739 1380-1392 NN denotes upregulation
T740 1393-1395 IN denotes of
T741 1396-1399 NNP denotes Id1
T742 1399-1400 . denotes .
T1730 1414-1421 NNS denotes Members
T1731 1422-1424 IN denotes of
T1732 1425-1428 DT denotes the
T1733 1429-1441 VBG denotes transforming
T1734 1442-1448 NN denotes growth
T1735 1449-1455 NN denotes factor
T1736 1456-1457 NN denotes β
T1737 1458-1459 -LRB- denotes (
T1738 1459-1464 NNP denotes TGF-β
T1739 1464-1465 -RRB- denotes )
T1740 1466-1477 RB denotes superfamily
T1741 1478-1482 VB denotes play
T1742 1483-1490 JJ denotes central
T1743 1491-1496 NNS denotes roles
T1744 1497-1499 IN denotes in
T1745 1500-1511 VBG denotes controlling
T1746 1512-1520 JJ denotes cellular
T1747 1521-1534 NN denotes proliferation
T1748 1534-1535 , denotes ,
T1749 1536-1551 NN denotes differentiation
T1750 1551-1552 , denotes ,
T1751 1553-1562 NN denotes migration
T1752 1563-1566 CC denotes and
T1753 1567-1576 NN denotes apoptosis
T1754 1577-1578 NN denotes [
T1755 1578-1579 CD denotes 1
T1756 1579-1580 NNP denotes ]
T1757 1580-1581 . denotes .
T1758 1582-1587 DT denotes These
T1759 1588-1597 NNS denotes cytokines
T1760 1598-1601 MD denotes can
T1761 1602-1604 VB denotes be
T1762 1605-1612 VBN denotes divided
T1763 1613-1617 IN denotes into
T1764 1618-1623 CD denotes three
T1765 1624-1633 NNS denotes subgroups
T1766 1633-1634 : denotes :
T1767 1635-1640 JJ denotes TGF-β
T1768 1640-1641 , denotes ,
T1769 1642-1645 DT denotes the
T1770 1646-1663 NNS denotes activins/inhibins
T1771 1663-1664 , denotes ,
T1772 1665-1668 CC denotes and
T1773 1669-1672 DT denotes the
T1774 1673-1677 NN denotes bone
T1775 1678-1691 JJ denotes morphogenetic
T1776 1692-1700 NNS denotes proteins
T1777 1701-1702 -LRB- denotes (
T1778 1702-1706 NNS denotes BMPs
T1779 1706-1707 -RRB- denotes )
T1780 1707-1708 , denotes ,
T1781 1709-1711 IN denotes of
T1782 1712-1717 WDT denotes which
T1783 1718-1721 DT denotes the
T1784 1722-1728 JJ denotes latter
T1785 1729-1739 VBP denotes constitute
T1786 1740-1743 DT denotes the
T1787 1744-1751 JJS denotes largest
T1788 1752-1758 NN denotes family
T1789 1758-1759 . denotes .
T1790 1760-1764 NNS denotes BMPs
T1791 1765-1768 VBP denotes are
T1792 1769-1771 CD denotes 30
T1793 1772-1774 CD denotes 38
T1794 1775-1778 NN denotes kDa
T1795 1779-1785 NN denotes hetero
T1796 1785-1786 : denotes -
T1797 1787-1789 CC denotes or
T1798 1790-1801 JJ denotes homodimeric
T1799 1802-1810 NNS denotes proteins
T1800 1811-1821 RB denotes originally
T1801 1822-1832 VBN denotes identified
T1802 1833-1835 IN denotes by
T1803 1836-1841 PRP$ denotes their
T1804 1842-1849 NN denotes ability
T1805 1850-1852 TO denotes to
T1806 1853-1859 VB denotes induce
T1807 1860-1867 JJ denotes ectopic
T1808 1868-1877 NN denotes cartilage
T1809 1878-1881 CC denotes and
T1810 1882-1886 NN denotes bone
T1811 1887-1896 NN denotes formation
T1812 1897-1898 NNP denotes [
T1813 1898-1901 CD denotes 2,3
T1814 1901-1902 NNP denotes ]
T1815 1902-1903 . denotes .
T1816 1904-1911 JJ denotes Several
T1817 1912-1919 NNS denotes studies
T1818 1920-1924 VBP denotes have
T1819 1925-1937 VBN denotes demonstrated
T1820 1938-1940 DT denotes an
T1821 1941-1950 JJ denotes essential
T1822 1951-1955 NN denotes role
T1823 1956-1958 IN denotes of
T1824 1959-1964 DT denotes these
T1825 1965-1973 NNS denotes proteins
T1826 1974-1980 IN denotes during
T1827 1981-1994 NN denotes embryogenesis
T1828 1994-1995 , denotes ,
T1829 1996-1999 CC denotes and
T1830 2000-2004 RBR denotes more
T1831 2005-2013 RB denotes recently
T1832 2013-2014 , denotes ,
T1833 2015-2019 RB denotes also
T1834 2020-2022 IN denotes in
T1835 2023-2028 NN denotes adult
T1836 2029-2036 NNS denotes tissues
T1837 2037-2038 VBP denotes [
T1838 2038-2039 CD denotes 1
T1839 2039-2040 NNP denotes ]
T1840 2040-2041 . denotes .
T1841 2042-2047 NNP denotes TGF-β
T1842 2048-2051 VBZ denotes has
T1843 2052-2056 VBN denotes been
T1844 2057-2068 RB denotes intensively
T1845 2069-2076 VBN denotes studied
T1846 2077-2079 IN denotes in
T1847 2080-2086 JJ denotes normal
T1848 2087-2090 CC denotes and
T1849 2091-2100 JJ denotes malignant
T1850 2101-2115 JJ denotes haematopoietic
T1851 2116-2121 NNS denotes cells
T1852 2122-2125 CC denotes and
T1853 2126-2128 VBZ denotes is
T1854 2129-2132 CD denotes one
T1855 2133-2135 IN denotes of
T1856 2136-2139 DT denotes the
T1857 2140-2144 RBS denotes most
T1858 2145-2151 JJ denotes potent
T1859 2152-2162 JJ denotes endogenous
T1860 2163-2171 JJ denotes negative
T1861 2172-2182 NNS denotes regulators
T1862 2183-2188 VBN denotes known
T1863 2189-2191 TO denotes to
T1864 2192-2196 NN denotes date
T1865 2196-2197 . denotes .
T1866 2198-2199 NN denotes [
T1867 2199-2200 CD denotes 4
T1868 2200-2201 NNP denotes ]
T1869 2201-2202 . denotes .
T1870 2203-2205 IN denotes In
T1871 2206-2214 NN denotes contrast
T1872 2214-2215 , denotes ,
T1873 2216-2219 DT denotes the
T1874 2220-2226 NN denotes effect
T1875 2227-2229 IN denotes of
T1876 2230-2234 NNS denotes BMPs
T1877 2235-2237 IN denotes in
T1878 2238-2241 DT denotes the
T1879 2242-2248 JJ denotes immune
T1880 2249-2255 NN denotes system
T1881 2256-2259 VBZ denotes has
T1882 2260-2263 RB denotes not
T1883 2264-2268 VBN denotes been
T1884 2269-2275 RB denotes widely
T1885 2276-2288 VBN denotes investigated
T1886 2288-2289 . denotes .
T1887 2290-2292 IN denotes In
T1888 2293-2297 DT denotes that
T1889 2298-2305 NN denotes respect
T1890 2305-2306 , denotes ,
T1891 2307-2310 NN denotes BMP
T1892 2310-2311 : denotes -
T1893 2312-2313 CD denotes 2
T1894 2313-2314 , denotes ,
T1895 2315-2317 CD denotes -4
T1896 2318-2321 CC denotes and
T1897 2322-2324 CD denotes -7
T1898 2325-2329 VBP denotes have
T1899 2330-2334 VBN denotes been
T1900 2335-2340 VBN denotes found
T1901 2341-2343 TO denotes to
T1902 2344-2351 VB denotes control
T1903 2352-2367 NN denotes differentiation
T1904 2368-2370 IN denotes of
T1905 2371-2384 JJ denotes hematopoietic
T1906 2385-2389 NN denotes stem
T1907 2390-2395 NNS denotes cells
T1908 2396-2397 VBP denotes [
T1909 2397-2398 CD denotes 5
T1910 2398-2399 NNP denotes ]
T1911 2400-2403 CC denotes and
T1912 2404-2409 JJ denotes early
T1913 2410-2411 NN denotes T
T1914 2412-2416 NN denotes cell
T1915 2417-2428 NN denotes development
T1916 2429-2430 NNP denotes [
T1917 2430-2433 CD denotes 6,7
T1918 2433-2434 NNP denotes ]
T1919 2434-2435 . denotes .
T1920 2436-2441 NN denotes BMP-6
T1921 2442-2445 VBZ denotes has
T1922 2446-2450 VBN denotes been
T1923 2451-2459 VBN denotes reported
T1924 2460-2462 TO denotes to
T1925 2463-2469 VB denotes reduce
T1926 2470-2473 DT denotes the
T1927 2474-2480 NN denotes number
T1928 2481-2483 IN denotes of
T1929 2484-2508 JJ denotes cobblestone-area-forming
T1930 2509-2514 NNS denotes cells
T1931 2515-2517 IN denotes of
T1932 2518-2524 JJ denotes normal
T1933 2525-2530 JJ denotes human
T1934 2531-2545 JJ denotes haematopoietic
T1935 2546-2551 NNS denotes cells
T1936 2552-2553 VBP denotes [
T1937 2553-2554 CD denotes 8
T1938 2554-2555 NNP denotes ]
T1939 2555-2556 . denotes .
T1940 2557-2568 RB denotes Furthermore
T1941 2568-2569 , denotes ,
T1942 2570-2575 NNP denotes BMP-2
T1943 2575-2576 , denotes ,
T1944 2577-2579 CD denotes -4
T1945 2579-2580 , denotes ,
T1946 2581-2582 CD denotes 6
T1947 2583-2586 CC denotes and
T1948 2587-2589 CD denotes -7
T1949 2590-2593 VBD denotes had
T1950 2594-2596 DT denotes an
T1951 2597-2614 JJ denotes antiproliferative
T1952 2615-2618 CC denotes and
T1953 2619-2620 DT denotes a
T1954 2621-2633 JJ denotes proapoptotic
T1955 2634-2640 NN denotes effect
T1956 2641-2643 IN denotes on
T1957 2644-2652 JJ denotes multiple
T1958 2653-2660 NN denotes myeloma
T1959 2661-2666 NNS denotes cells
T1960 2667-2668 NNP denotes [
T1961 2668-2672 CD denotes 9-11
T1962 2672-2673 NNP denotes ]
T1963 2673-2674 . denotes .
T1964 2675-2677 IN denotes In
T1965 2678-2686 NN denotes addition
T1966 2686-2687 , denotes ,
T1967 2688-2690 IN denotes by
T1968 2691-2695 NN denotes gene
T1969 2696-2706 NN denotes expression
T1970 2707-2716 NN denotes profiling
T1971 2716-2717 , denotes ,
T1972 2718-2723 NNP denotes BMP-6
T1973 2724-2737 RB denotes significantly
T1974 2738-2747 VBD denotes increased
T1975 2748-2751 DT denotes the
T1976 2752-2762 JJ denotes predictive
T1977 2763-2768 NN denotes value
T1978 2769-2772 IN denotes for
T1979 2773-2774 DT denotes a
T1980 2775-2785 JJ denotes multi-gene
T1981 2786-2795 NN denotes signature
T1982 2796-2800 NN denotes test
T1983 2801-2804 CC denotes and
T1984 2805-2808 VBD denotes was
T1985 2809-2819 VBN denotes associated
T1986 2820-2824 IN denotes with
T1987 2825-2826 DT denotes a
T1988 2827-2831 JJ denotes poor
T1989 2832-2839 NN denotes outcome
T1990 2840-2842 IN denotes in
T1991 2843-2850 NN denotes diffuse
T1992 2851-2856 JJ denotes large
T1993 2857-2858 NNP denotes B
T1994 2859-2863 NN denotes cell
T1995 2864-2873 NNS denotes lymphomas
T1996 2874-2875 -LRB- denotes (
T1997 2875-2880 NNP denotes DLBCL
T1998 2880-2881 -RRB- denotes )
T1999 2882-2883 NNP denotes [
T2000 2883-2885 CD denotes 12
T2001 2885-2886 NNP denotes ]
T2002 2886-2887 . denotes .
T2003 2888-2893 NN denotes BMP-6
T2004 2893-2894 , denotes ,
T2005 2895-2899 IN denotes like
T2006 2900-2903 DT denotes the
T2007 2904-2909 JJ denotes other
T2008 2910-2913 NN denotes BMP
T2009 2914-2921 NNS denotes members
T2010 2921-2922 , denotes ,
T2011 2923-2930 NNS denotes signals
T2012 2931-2938 IN denotes through
T2013 2939-2947 NN denotes ligation
T2014 2948-2951 CC denotes and
T2015 2952-2969 NN denotes heterodimerzation
T2016 2970-2972 IN denotes of
T2017 2973-2976 NN denotes BMP
T2018 2977-2981 NN denotes type
T2019 2982-2983 PRP denotes I
T2020 2984-2985 VBP denotes [
T2021 2985-3004 NN denotes activin-like-kinase
T2022 3005-3006 -LRB- denotes (
T2023 3006-3009 NNP denotes ALK
T2024 3009-3010 -RRB- denotes )
T2025 3010-3011 NNP denotes ]
T2026 3012-3015 CC denotes and
T2027 3016-3020 NN denotes type
T2028 3021-3023 NNP denotes II
T2029 3024-3040 JJ denotes serine-threonine
T2030 3041-3047 NN denotes kinase
T2031 3048-3057 NNS denotes receptors
T2032 3057-3058 , denotes ,
T2033 3059-3064 WDT denotes which
T2034 3065-3077 RB denotes subsequently
T2035 3078-3088 VBZ denotes propagates
T2036 3089-3092 DT denotes the
T2037 3093-3099 NN denotes signal
T2038 3100-3110 JJ denotes downstream
T2039 3111-3113 IN denotes by
T2040 3114-3129 VBG denotes phosphorylating
T2041 3130-3134 NNP denotes Smad
T2042 3135-3143 NNS denotes proteins
T2043 3143-3144 . denotes .
T2044 3145-3150 NN denotes BMP-6
T2045 3151-3154 MD denotes can
T2046 3155-3161 VB denotes signal
T2047 3162-3169 IN denotes through
T2048 3170-3173 DT denotes the
T2049 3174-3182 NN denotes ligation
T2050 3183-3185 IN denotes of
T2051 3186-3189 DT denotes the
T2052 3190-3194 NN denotes type
T2053 3195-3196 PRP denotes I
T2054 3197-3206 NNS denotes receptors
T2055 3207-3214 NNP denotes Act-RIA
T2056 3214-3215 , denotes ,
T2057 3216-3223 NNP denotes BMP-RIA
T2058 3223-3224 , denotes ,
T2059 3225-3228 CC denotes and
T2060 3229-3236 NNP denotes BMP-RIB
T2061 3237-3240 CC denotes and
T2062 3241-3244 DT denotes the
T2063 3245-3249 NN denotes type
T2064 3250-3252 NNP denotes II
T2065 3253-3262 NNS denotes receptors
T2066 3263-3270 NNP denotes BMP-RII
T2067 3270-3271 , denotes ,
T2068 3272-3280 NNP denotes Act-RIIA
T2069 3281-3284 CC denotes and
T2070 3285-3293 NNP denotes Act-RIIB
T2071 3293-3294 , denotes ,
T2072 3295-3300 WDT denotes which
T2073 3301-3305 VBP denotes lead
T2074 3306-3308 TO denotes to
T2075 3309-3312 DT denotes the
T2076 3313-3328 NN denotes phosphorylation
T2077 3329-3331 IN denotes of
T2078 3332-3335 DT denotes the
T2079 3336-3344 NN denotes receptor
T2080 3345-3350 NNS denotes Smads
T2081 3351-3352 -LRB- denotes (
T2082 3352-3358 NNP denotes Smad-1
T2083 3358-3359 , denotes ,
T2084 3360-3366 NNP denotes Smad-5
T2085 3366-3367 , denotes ,
T2086 3368-3371 CC denotes and
T2087 3372-3378 NNP denotes Smad-8
T2088 3378-3379 -RRB- denotes )
T2089 3379-3380 . denotes .
T2090 3381-3384 DT denotes The
T2091 3385-3386 NN denotes R
T2092 3386-3387 : denotes -
T2093 3388-3393 NNS denotes Smads
T2094 3394-3398 RB denotes then
T2095 3399-3403 VBP denotes form
T2096 3404-3413 NNS denotes complexes
T2097 3414-3418 IN denotes with
T2098 3419-3422 DT denotes the
T2099 3423-3430 NNP denotes co-Smad
T2100 3431-3432 -LRB- denotes (
T2101 3432-3437 NNP denotes Smad4
T2102 3437-3438 -RRB- denotes )
T2103 3439-3442 CC denotes and
T2104 3443-3446 VBP denotes are
T2105 3447-3459 VBN denotes translocated
T2106 3460-3464 IN denotes into
T2107 3465-3468 DT denotes the
T2108 3469-3476 NN denotes nucleus
T2109 3477-3482 WRB denotes where
T2110 3483-3487 PRP denotes they
T2111 3488-3493 VBP denotes exert
T2112 3494-3498 NN denotes gene
T2113 3499-3509 NN denotes regulation
T2114 3510-3511 NNP denotes [
T2115 3511-3515 CD denotes 1,13
T2116 3515-3516 NNP denotes ]
T2117 3516-3517 . denotes .
T2118 3518-3523 VBN denotes Given
T2119 3524-3527 DT denotes the
T2120 3528-3536 VBN denotes reported
T2121 3537-3541 NN denotes role
T2122 3542-3544 IN denotes of
T2123 3545-3550 NNP denotes BMP-6
T2124 3551-3553 IN denotes in
T2125 3554-3560 NNP denotes B-cell
T2126 3561-3573 NNS denotes malignancies
T2127 3574-3577 CC denotes and
T2128 3578-3592 JJ denotes haematopoietic
T2129 3593-3603 NN denotes progenitor
T2130 3604-3609 NNS denotes cells
T2131 3609-3610 , denotes ,
T2132 3611-3613 PRP denotes we
T2133 3614-3620 VBD denotes wanted
T2134 3621-3623 TO denotes to
T2135 3624-3631 VB denotes explore
T2136 3632-3635 PRP$ denotes its
T2137 3636-3645 JJ denotes potential
T2138 3646-3650 NN denotes role
T2139 3651-3653 IN denotes in
T2140 3654-3660 JJ denotes normal
T2141 3661-3666 JJ denotes human
T2142 3667-3668 NNP denotes B
T2143 3669-3674 NNS denotes cells
T2144 3674-3675 . denotes .
T2145 3676-3678 PRP denotes We
T2146 3679-3686 VBD denotes studied
T2147 3687-3690 DT denotes the
T2148 3691-3698 NNS denotes effects
T2149 3699-3701 IN denotes of
T2150 3702-3707 NN denotes BMP-6
T2151 3708-3710 IN denotes on
T2152 3711-3724 NN denotes proliferation
T2153 3725-3728 CC denotes and
T2154 3729-3738 NN denotes apoptosis
T2155 3739-3741 IN denotes on
T2156 3742-3749 VBG denotes resting
T2157 3750-3753 CC denotes and
T2158 3754-3764 VBD denotes stimulated
T2159 3765-3766 NNP denotes B
T2160 3767-3772 NNS denotes cells
T2161 3772-3773 . denotes .
T2162 3774-3785 RB denotes Furthermore
T2163 3785-3786 , denotes ,
T2164 3787-3790 DT denotes the
T2165 3791-3801 NN denotes expression
T2166 3802-3804 IN denotes of
T2167 3805-3808 NN denotes BMP
T2168 3809-3818 NNS denotes receptors
T2169 3819-3822 CC denotes and
T2170 3823-3828 NNP denotes BMP-6
T2171 3829-3836 VBD denotes induced
T2172 3837-3847 NN denotes activation
T2173 3848-3850 IN denotes of
T2174 3851-3854 DT denotes the
T2175 3855-3859 NNP denotes Smad
T2176 3860-3870 JJ denotes signalling
T2177 3871-3878 NN denotes pathway
T2178 3879-3883 IN denotes with
T2179 3884-3894 JJ denotes subsequent
T2180 3895-3905 NN denotes regulation
T2181 3906-3908 IN denotes of
T2182 3909-3912 DT denotes the
T2183 3913-3919 NN denotes target
T2184 3920-3925 NNS denotes genes
T2185 3926-3929 VBP denotes Id1
T2186 3930-3933 NNP denotes Id4
T2187 3933-3934 , denotes ,
T2188 3935-3939 VBD denotes were
T2189 3940-3948 VBN denotes resolved
T2190 3948-3949 . denotes .
T2191 3950-3957 RB denotes Finally
T2192 3957-3958 , denotes ,
T2193 3959-3961 PRP denotes we
T2194 3962-3974 VBD denotes investigated
T2195 3975-3982 IN denotes whether
T2196 3983-3984 NNP denotes B
T2197 3985-3990 NNS denotes cells
T2198 3991-3995 RB denotes also
T2199 3996-4000 VBD denotes were
T2200 4001-4008 JJ denotes capable
T2201 4009-4011 IN denotes of
T2202 4012-4021 VBG denotes producing
T2203 4022-4027 NNP denotes BMP-6
T2204 4027-4028 . denotes .
T3082 4039-4044 CD denotes BMP-6
T3083 4045-4053 NNS denotes inhibits
T3084 4054-4062 JJ denotes anti-IgM
T3085 4063-4070 VBD denotes induced
T3086 4071-4084 NN denotes proliferation
T3087 4085-4087 IN denotes of
T3088 4088-4093 JJ denotes human
T3089 4094-4095 NNP denotes B
T3090 4096-4101 NNS denotes cells
T3091 4102-4105 DT denotes The
T3092 4106-4113 NNS denotes effects
T3093 4114-4116 IN denotes of
T3094 4117-4122 NN denotes BMP-6
T3095 4123-4125 IN denotes on
T3096 4126-4132 JJ denotes normal
T3097 4133-4136 CC denotes and
T3098 4137-4147 JJ denotes neoplastic
T3099 4148-4161 JJ denotes hematopoietic
T3100 4162-4167 NNS denotes cells
T3101 4168-4176 VBD denotes prompted
T3102 4177-4179 PRP denotes us
T3103 4180-4182 TO denotes to
T3104 4183-4194 VB denotes investigate
T3105 4195-4198 DT denotes the
T3106 4199-4206 NNS denotes effects
T3107 4207-4209 IN denotes of
T3108 4210-4215 NN denotes BMP-6
T3109 4216-4218 IN denotes on
T3110 4219-4225 JJ denotes normal
T3111 4226-4231 JJ denotes human
T3112 4232-4233 NNP denotes B
T3113 4234-4239 NNS denotes cells
T3114 4239-4240 . denotes .
T3115 4241-4244 DT denotes All
T3116 4245-4256 NNS denotes experiments
T3117 4257-4259 IN denotes in
T3118 4260-4264 DT denotes this
T3119 4265-4270 NN denotes study
T3120 4271-4275 VBD denotes were
T3121 4276-4285 VBN denotes performed
T3122 4286-4291 IN denotes under
T3123 4292-4302 JJ denotes serum-free
T3124 4303-4313 NNS denotes conditions
T3125 4314-4316 IN denotes as
T3126 4317-4320 NNP denotes FCS
T3127 4321-4324 VBZ denotes has
T3128 4325-4329 VBN denotes been
T3129 4330-4335 VBN denotes shown
T3130 4336-4338 TO denotes to
T3131 4339-4348 VB denotes interfere
T3132 4349-4353 IN denotes with
T3133 4354-4368 JJ denotes BMP-signalling
T3134 4369-4370 NNP denotes [
T3135 4370-4372 CD denotes 14
T3136 4372-4373 NNP denotes ]
T3137 4373-4374 -LRB- denotes (
T3138 4374-4377 JJ denotes own
T3139 4378-4390 NNS denotes observations
T3140 4390-4391 -RRB- denotes )
T3141 4391-4392 . denotes .
T3142 4393-4395 TO denotes To
T3143 4396-4401 VB denotes study
T3144 4402-4405 DT denotes the
T3145 4406-4412 NN denotes effect
T3146 4413-4415 IN denotes of
T3147 4416-4421 NN denotes BMP-6
T3148 4422-4424 IN denotes on
T3149 4425-4438 NN denotes proliferation
T3150 4438-4439 , denotes ,
T3151 4440-4447 NNPS denotes B-cells
T3152 4448-4452 IN denotes from
T3153 4453-4460 JJ denotes healthy
T3154 4461-4471 NNS denotes volunteers
T3155 4472-4476 VBD denotes were
T3156 4477-4487 VBN denotes stimulated
T3157 4488-4492 IN denotes with
T3158 4493-4501 JJ denotes anti-IgM
T3159 4502-4508 CC denotes and/or
T3160 4509-4514 CD denotes CD40L
T3161 4515-4517 IN denotes in
T3162 4518-4521 DT denotes the
T3163 4522-4530 NN denotes presence
T3164 4531-4533 CC denotes or
T3165 4534-4541 NN denotes absence
T3166 4542-4544 IN denotes of
T3167 4545-4550 NNP denotes BMP-6
T3168 4551-4554 IN denotes for
T3169 4555-4560 CD denotes three
T3170 4561-4565 NNS denotes days
T3171 4565-4566 . denotes .
T3172 4567-4569 PRP denotes We
T3173 4570-4575 VBD denotes found
T3174 4576-4580 IN denotes that
T3175 4581-4586 NNP denotes BMP-6
T3176 4587-4590 VBD denotes led
T3177 4591-4593 TO denotes to
T3178 4594-4595 DT denotes a
T3179 4596-4598 CD denotes 35
T3180 4598-4599 NN denotes %
T3181 4600-4604 JJ denotes mean
T3182 4605-4614 NN denotes reduction
T3183 4615-4617 IN denotes of
T3184 4618-4626 JJ denotes anti-IgM
T3185 4626-4627 : denotes -
T3186 4628-4635 VBD denotes induced
T3187 4636-4639 NNP denotes DNA
T3188 4640-4649 NN denotes synthesis
T3189 4650-4651 -LRB- denotes (
T3190 4651-4652 FW denotes n
T3191 4653-4654 SYM denotes =
T3192 4655-4656 CD denotes 8
T3193 4656-4657 : denotes ;
T3194 4658-4659 VB denotes p
T3195 4660-4661 NN denotes ≤
T3196 4662-4668 CD denotes 0.0002
T3197 4668-4669 , denotes ,
T3198 4670-4676 NNP denotes Figure
T3199 4677-4679 NNP denotes 1A
T3200 4679-4680 -RRB- denotes )
T3201 4680-4681 . denotes .
T3202 4682-4689 JJ denotes Similar
T3203 4690-4697 NNS denotes results
T3204 4698-4702 VBD denotes were
T3205 4703-4711 VBN denotes obtained
T3206 4712-4715 IN denotes for
T3207 4716-4717 NNP denotes B
T3208 4718-4723 NNS denotes cells
T3209 4724-4731 VBN denotes treated
T3210 4732-4736 IN denotes with
T3211 4737-4745 JJ denotes anti-IgM
T3212 4746-4749 CC denotes and
T3213 4750-4755 NNP denotes CD40L
T3214 4756-4757 -LRB- denotes (
T3215 4757-4759 CD denotes 26
T3216 4759-4760 NN denotes %
T3217 4761-4765 JJ denotes mean
T3218 4766-4775 NN denotes reduction
T3219 4775-4776 , denotes ,
T3220 4777-4778 NN denotes n
T3221 4779-4780 SYM denotes =
T3222 4781-4782 CD denotes 6
T3223 4782-4783 : denotes ;
T3224 4784-4785 VB denotes p
T3225 4786-4787 NN denotes ≤
T3226 4788-4793 CD denotes 0.023
T3227 4793-4794 -RRB- denotes )
T3228 4794-4795 . denotes .
T3229 4796-4799 DT denotes The
T3230 4800-4813 JJ denotes BMP-6-induced
T3231 4814-4824 NN denotes inhibition
T3232 4825-4827 IN denotes of
T3233 4828-4841 NN denotes proliferation
T3234 4842-4845 VBD denotes was
T3235 4846-4860 JJ denotes dose-dependent
T3236 4861-4863 IN denotes in
T3237 4864-4868 DT denotes both
T3238 4869-4879 JJ denotes peripheral
T3239 4880-4881 NNP denotes B
T3240 4882-4887 NNS denotes cells
T3241 4888-4889 -LRB- denotes (
T3242 4889-4895 NN denotes Figure
T3243 4896-4898 NN denotes 1B
T3244 4898-4899 -RRB- denotes )
T3245 4900-4903 CC denotes and
T3246 4904-4907 DT denotes the
T3247 4908-4915 NNP denotes Burkitt
T3248 4916-4924 NN denotes lymphoma
T3249 4925-4929 NN denotes cell
T3250 4930-4934 NN denotes line
T3251 4935-4940 NNP denotes Ramos
T3252 4941-4942 -LRB- denotes (
T3253 4942-4944 CD denotes 40
T3254 4944-4945 NN denotes %
T3255 4946-4955 NN denotes reduction
T3256 4956-4958 IN denotes of
T3257 4959-4962 NNP denotes DNA
T3258 4963-4972 NN denotes synthesis
T3259 4972-4973 , denotes ,
T3260 4974-4980 NNP denotes Figure
T3261 4981-4983 NNP denotes 1C
T3262 4983-4984 -RRB- denotes )
T3263 4984-4985 . denotes .
T3264 4986-4989 DT denotes The
T3265 4990-4995 NNP denotes BMP-6
T3266 4996-5003 NNS denotes effects
T3267 5004-5009 MD denotes could
T3268 5010-5012 VB denotes be
T3269 5013-5021 VBN denotes reversed
T3270 5022-5024 IN denotes by
T3271 5025-5033 NN denotes addition
T3272 5034-5036 IN denotes of
T3274 5041-5054 JJ denotes extracellular
T3275 5055-5064 NN denotes inhibitor
T3276 5065-5071 NNP denotes Noggin
T3277 5072-5073 -LRB- denotes (
T3278 5073-5079 NNP denotes Figure
T3279 5080-5082 NNP denotes 1D
T3280 5082-5083 -RRB- denotes )
T3281 5083-5084 . denotes .
T3282 5085-5094 RB denotes Similarly
T3283 5094-5095 , denotes ,
T3284 5096-5097 DT denotes a
T3285 5098-5109 NN denotes combination
T3286 5110-5112 IN denotes of
T3287 5113-5116 DT denotes the
T3288 5117-5124 JJ denotes soluble
T3289 5125-5128 NN denotes BMP
T3290 5129-5138 NNS denotes receptors
T3291 5139-5149 NNP denotes BMP-RIB-Fc
T3292 5150-5153 CC denotes and
T3293 5154-5164 NNP denotes BMP-RII-Fc
T3294 5165-5169 RB denotes also
T3295 5170-5181 VBD denotes neutralized
T3296 5182-5185 DT denotes the
T3297 5186-5193 NNS denotes effects
T3298 5194-5196 IN denotes of
T3299 5197-5202 NNP denotes BMP-6
T3300 5203-5204 -LRB- denotes (
T3301 5204-5208 NNS denotes data
T3302 5209-5212 RB denotes not
T3303 5213-5218 VBN denotes shown
T3304 5218-5219 -RRB- denotes )
T3305 5219-5220 . denotes .
T3306 5221-5225 JJ denotes Next
T3307 5225-5226 , denotes ,
T3308 5227-5229 PRP denotes we
T3309 5230-5236 VBD denotes wanted
T3310 5237-5239 TO denotes to
T3311 5240-5244 VB denotes test
T3312 5245-5252 IN denotes whether
T3313 5253-5258 NNP denotes BMP-6
T3314 5259-5262 VBD denotes had
T3315 5263-5272 JJ denotes different
T3316 5273-5279 NN denotes effect
T3317 5280-5282 IN denotes on
T3318 5283-5288 NN denotes naïve
T3319 5289-5292 CC denotes and
T3320 5293-5299 NN denotes memory
T3321 5300-5301 NNP denotes B
T3322 5302-5307 NNS denotes cells
T3323 5307-5308 . denotes .
T3324 5309-5314 NNP denotes Naïve
T3325 5315-5316 -LRB- denotes (
T3326 5316-5320 NNP denotes CD19
T3327 5320-5321 NNP denotes +
T3328 5321-5325 NNP denotes CD27
T3329 5325-5326 : denotes -
T3330 5326-5327 -RRB- denotes )
T3331 5328-5331 CC denotes and
T3332 5332-5338 NN denotes memory
T3333 5339-5340 -LRB- denotes (
T3334 5340-5344 CD denotes CD19
T3335 5344-5345 NN denotes +
T3336 5345-5349 NNP denotes CD27
T3337 5349-5350 NNP denotes +
T3338 5350-5351 -RRB- denotes )
T3339 5352-5353 NNP denotes B
T3340 5354-5359 NNS denotes cells
T3341 5360-5364 VBD denotes were
T3342 5365-5373 VBN denotes isolated
T3343 5374-5378 IN denotes from
T3344 5379-5389 JJ denotes peripheral
T3345 5390-5395 NN denotes blood
T3346 5396-5398 IN denotes by
T3347 5399-5403 NN denotes cell
T3348 5404-5411 VBG denotes sorting
T3349 5412-5414 IN denotes of
T3350 5415-5434 JJ denotes immunobead-isolated
T3351 5435-5439 NNP denotes CD19
T3352 5439-5440 NNP denotes +
T3353 5441-5442 NNP denotes B
T3354 5443-5448 NNS denotes cells
T3355 5449-5450 NNP denotes [
T3356 5450-5452 CD denotes 15
T3357 5452-5453 NNP denotes ]
T3358 5453-5454 , denotes ,
T3359 5455-5458 CC denotes and
T3360 5459-5465 VBN denotes tested
T3361 5466-5469 IN denotes for
T3362 5470-5475 PRP$ denotes their
T3363 5476-5484 NN denotes capacity
T3364 5485-5487 TO denotes to
T3365 5488-5499 VB denotes proliferate
T3366 5500-5502 IN denotes in
T3367 5503-5506 DT denotes the
T3368 5507-5515 NN denotes presence
T3369 5516-5518 IN denotes of
T3370 5519-5524 NNP denotes BMP-6
T3371 5524-5525 . denotes .
T3372 5526-5533 RB denotes However
T3373 5533-5534 , denotes ,
T3374 5535-5540 NNP denotes BMP-6
T3375 5541-5550 VBD denotes inhibited
T3376 5551-5559 JJ denotes anti-IgM
T3377 5560-5567 JJ denotes induced
T3378 5568-5571 NN denotes DNA
T3379 5572-5581 NN denotes synthesis
T3380 5582-5584 IN denotes in
T3381 5585-5588 DT denotes the
T3382 5589-5592 CD denotes two
T3383 5593-5607 NNS denotes subpopulations
T3384 5608-5610 TO denotes to
T3385 5611-5612 DT denotes a
T3386 5613-5620 JJ denotes similar
T3387 5621-5627 NN denotes extent
T3388 5627-5628 , denotes ,
T3389 5629-5633 IN denotes with
T3390 5634-5635 DT denotes a
T3391 5636-5640 JJ denotes mean
T3392 5641-5650 NN denotes reduction
T3393 5651-5653 IN denotes of
T3394 5654-5667 NN denotes DNA-synthesis
T3395 5668-5670 IN denotes of
T3396 5671-5673 CD denotes 45
T3397 5673-5674 NN denotes %
T3398 5675-5676 -LRB- denotes (
T3399 5676-5677 FW denotes n
T3400 5678-5679 SYM denotes =
T3401 5680-5681 CD denotes 5
T3402 5681-5682 : denotes ;
T3403 5683-5684 VB denotes p
T3404 5685-5686 NN denotes ≤
T3405 5687-5692 CD denotes 0,004
T3406 5692-5693 -RRB- denotes )
T3407 5694-5697 IN denotes for
T3408 5698-5703 NN denotes naïve
T3409 5704-5705 NNP denotes B
T3410 5706-5711 NNS denotes cells
T3411 5712-5715 CC denotes and
T3412 5716-5718 CD denotes 48
T3413 5718-5719 NN denotes %
T3414 5720-5721 -LRB- denotes (
T3415 5721-5722 FW denotes n
T3416 5723-5724 SYM denotes =
T3417 5725-5726 CD denotes 5
T3418 5726-5727 : denotes ;
T3419 5728-5729 VB denotes p
T3420 5730-5731 NN denotes ≤
T3421 5732-5737 CD denotes 0,001
T3422 5737-5738 -RRB- denotes )
T3423 5739-5742 IN denotes for
T3424 5743-5749 NN denotes memory
T3425 5750-5751 NNP denotes B
T3426 5752-5757 NNS denotes cells
T3427 5758-5759 -LRB- denotes (
T3428 5759-5765 NN denotes Figure
T3429 5766-5768 CD denotes 1E
T3430 5768-5769 -RRB- denotes )
T3431 5769-5770 . denotes .
T3786 5772-5777 CD denotes BMP-6
T3787 5778-5785 VBZ denotes induces
T3788 5786-5790 NN denotes cell
T3789 5791-5796 NN denotes death
T3790 5797-5799 IN denotes in
T3791 5800-5805 JJ denotes human
T3792 5806-5812 NN denotes memory
T3793 5813-5814 NNP denotes B
T3794 5815-5820 NNS denotes cells
T3795 5821-5824 CC denotes and
T3796 5825-5830 NNP denotes Ramos
T3797 5831-5836 NNS denotes cells
T3798 5837-5841 JJ denotes Next
T3799 5841-5842 , denotes ,
T3800 5843-5845 PRP denotes we
T3801 5846-5852 VBD denotes wanted
T3802 5853-5855 TO denotes to
T3803 5856-5865 VB denotes establish
T3804 5866-5873 IN denotes whether
T3805 5874-5879 NNP denotes BMP-6
T3806 5880-5884 RB denotes also
T3807 5885-5890 MD denotes could
T3808 5891-5897 VB denotes affect
T3809 5898-5901 DT denotes the
T3810 5902-5911 NN denotes viability
T3811 5912-5914 IN denotes of
T3812 5915-5921 JJ denotes normal
T3813 5922-5923 NNP denotes B
T3814 5924-5929 NNS denotes cells
T3815 5929-5930 . denotes .
T3816 5931-5935 NNP denotes Cell
T3817 5936-5945 NN denotes viability
T3818 5946-5949 VBD denotes was
T3819 5950-5960 VBN denotes determined
T3820 5961-5963 IN denotes by
T3821 5964-5973 NN denotes propidium
T3822 5974-5980 NN denotes iodide
T3823 5981-5982 -LRB- denotes (
T3824 5982-5984 NNP denotes PI
T3825 5984-5985 -RRB- denotes )
T3826 5986-5994 VBG denotes staining
T3827 5995-6000 IN denotes after
T3828 6001-6008 NN denotes culture
T3829 6009-6013 IN denotes with
T3830 6014-6016 CC denotes or
T3831 6017-6024 IN denotes without
T3832 6025-6030 NNP denotes BMP-6
T3833 6031-6034 IN denotes for
T3834 6035-6037 CD denotes 48
T3835 6038-6043 NNS denotes hours
T3836 6043-6044 . denotes .
T3837 6045-6058 RB denotes Interestingly
T3838 6058-6059 , denotes ,
T3839 6060-6065 NNP denotes BMP-6
T3840 6066-6072 VBD denotes showed
T3841 6073-6074 DT denotes a
T3842 6075-6080 JJ denotes small
T3843 6080-6081 , denotes ,
T3844 6082-6085 CC denotes but
T3845 6086-6098 JJ denotes reproducible
T3846 6099-6103 JJ denotes mean
T3847 6104-6112 NN denotes increase
T3848 6113-6115 IN denotes of
T3849 6116-6120 NN denotes cell
T3850 6121-6126 NN denotes death
T3851 6127-6131 IN denotes from
T3852 6132-6134 CD denotes 17
T3853 6135-6137 TO denotes to
T3854 6138-6140 CD denotes 23
T3855 6140-6141 NN denotes %
T3856 6142-6143 -LRB- denotes (
T3857 6143-6144 FW denotes n
T3858 6145-6146 SYM denotes =
T3859 6147-6148 CD denotes 5
T3860 6148-6149 : denotes ;
T3861 6150-6151 VB denotes p
T3862 6152-6153 NN denotes ≤
T3863 6154-6159 CD denotes 0,003
T3864 6159-6160 -RRB- denotes )
T3865 6161-6163 IN denotes in
T3866 6164-6172 JJ denotes anti-IgM
T3867 6173-6183 VBN denotes stimulated
T3868 6184-6188 NNP denotes CD27
T3869 6188-6189 NNP denotes +
T3870 6190-6196 NN denotes memory
T3871 6197-6198 NNP denotes B
T3872 6199-6204 NNS denotes cells
T3873 6204-6205 . denotes .
T3874 6206-6217 RB denotes Furthermore
T3875 6217-6218 , denotes ,
T3876 6219-6224 NNP denotes Ramos
T3877 6225-6230 NNS denotes cells
T3878 6231-6237 VBD denotes showed
T3879 6238-6239 DT denotes a
T3880 6240-6244 JJ denotes mean
T3881 6245-6253 NN denotes increase
T3882 6254-6256 IN denotes in
T3883 6257-6261 NN denotes cell
T3884 6262-6267 NN denotes death
T3885 6268-6272 IN denotes from
T3886 6273-6275 CD denotes 20
T3887 6276-6278 TO denotes to
T3888 6279-6281 CD denotes 50
T3889 6281-6282 NN denotes %
T3890 6283-6284 -LRB- denotes (
T3891 6284-6285 FW denotes n
T3892 6286-6287 SYM denotes =
T3893 6288-6289 CD denotes 3
T3894 6289-6290 , denotes ,
T3895 6291-6292 NN denotes p
T3896 6293-6294 NN denotes <
T3897 6295-6300 CD denotes 0,001
T3898 6300-6301 , denotes ,
T3899 6302-6308 NN denotes figure
T3900 6309-6310 CD denotes 3
T3901 6310-6311 -RRB- denotes )
T3902 6312-6317 IN denotes after
T3903 6318-6323 NNP denotes BMP-6
T3904 6324-6333 NN denotes treatment
T3905 6333-6334 . denotes .
T3906 6335-6337 IN denotes In
T3907 6338-6346 NN denotes contrast
T3908 6346-6347 , denotes ,
T3909 6348-6352 NN denotes cell
T3910 6353-6358 NN denotes death
T3911 6359-6361 IN denotes of
T3912 6362-6367 JJ denotes total
T3913 6368-6372 NNP denotes CD19
T3914 6372-6373 NN denotes +
T3915 6374-6379 NNS denotes cells
T3916 6380-6381 -LRB- denotes (
T3917 6381-6382 FW denotes n
T3918 6383-6384 SYM denotes =
T3919 6385-6386 CD denotes 6
T3920 6386-6387 : denotes ;
T3921 6388-6389 VB denotes p
T3922 6390-6391 NN denotes ≤
T3923 6392-6396 CD denotes 0,32
T3924 6396-6397 : denotes ;
T3925 6398-6402 NNS denotes data
T3926 6403-6406 RB denotes not
T3927 6407-6412 VBN denotes shown
T3928 6412-6413 -RRB- denotes )
T3929 6414-6416 CC denotes or
T3930 6417-6425 NN denotes CD27-IgG
T3931 6425-6426 : denotes -
T3932 6427-6432 NN denotes naïve
T3933 6433-6434 NNP denotes B
T3934 6435-6440 NNS denotes cells
T3935 6441-6444 VBD denotes was
T3936 6445-6448 RB denotes not
T3937 6449-6462 RB denotes significantly
T3938 6463-6471 JJ denotes affected
T3939 6472-6473 -LRB- denotes (
T3940 6473-6474 JJ denotes n
T3941 6475-6476 SYM denotes =
T3942 6477-6478 CD denotes 5
T3943 6478-6479 : denotes ;
T3944 6480-6481 VB denotes p
T3945 6482-6483 NN denotes ≤
T3946 6484-6488 CD denotes 0,65
T3947 6488-6489 , denotes ,
T3948 6490-6496 NN denotes figure
T3949 6497-6498 CD denotes 2
T3950 6498-6499 -RRB- denotes )
T3951 6499-6500 . denotes .
T4266 6502-6507 NNP denotes Human
T4267 6508-6509 NNP denotes B
T4268 6510-6515 NNS denotes cells
T4269 6516-6523 VBP denotes express
T4270 6524-6529 NNP denotes BMP-6
T4271 6530-6539 NNS denotes receptors
T4272 6540-6548 JJ denotes Detailed
T4273 6549-6558 NN denotes knowledge
T4274 6559-6568 VBG denotes regarding
T4275 6569-6579 NN denotes expression
T4276 6580-6582 IN denotes of
T4277 6583-6592 JJ denotes different
T4278 6593-6596 NN denotes BMP
T4279 6597-6606 NNS denotes receptors
T4280 6607-6609 IN denotes in
T4281 6610-6611 NNP denotes B
T4282 6612-6617 NNS denotes cells
T4283 6618-6620 VBZ denotes is
T4284 6621-6630 RB denotes currently
T4285 6631-6634 RB denotes not
T4286 6635-6644 JJ denotes available
T4287 6644-6645 . denotes .
T4288 6646-6648 TO denotes To
T4289 6649-6656 RBR denotes further
T4290 6657-6666 VB denotes elucidate
T4291 6667-6670 DT denotes the
T4292 6671-6675 NN denotes role
T4293 6676-6678 IN denotes of
T4294 6679-6683 NNS denotes BMPs
T4295 6684-6686 IN denotes in
T4296 6687-6692 JJ denotes human
T4297 6693-6694 NNP denotes B
T4298 6695-6700 NNS denotes cells
T4299 6700-6701 , denotes ,
T4300 6702-6704 PRP denotes we
T4301 6705-6714 VBD denotes performed
T4302 6715-6722 JJ denotes western
T4303 6723-6727 NN denotes blot
T4304 6728-6736 NN denotes analysis
T4305 6737-6740 IN denotes for
T4306 6741-6745 NN denotes type
T4307 6746-6747 PRP denotes I
T4308 6748-6751 CC denotes and
T4309 6752-6756 NN denotes type
T4310 6757-6759 NNP denotes II
T4311 6760-6763 NN denotes BMP
T4312 6764-6773 NNS denotes receptors
T4313 6773-6774 . denotes .
T4314 6775-6779 DT denotes This
T4315 6780-6788 NN denotes analysis
T4316 6789-6797 VBD denotes revealed
T4317 6798-6802 IN denotes that
T4318 6803-6806 DT denotes the
T4319 6807-6811 NN denotes type
T4320 6812-6813 PRP denotes I
T4321 6814-6823 NNS denotes receptors
T4322 6824-6831 NNP denotes Act-RIA
T4323 6831-6832 , denotes ,
T4324 6833-6840 NNP denotes BMP-RIB
T4325 6841-6844 CC denotes and
T4326 6845-6848 DT denotes the
T4327 6849-6853 NN denotes type
T4328 6854-6856 NNP denotes II
T4329 6857-6866 NNS denotes receptors
T4330 6867-6874 NNP denotes BMP-RII
T4331 6875-6878 CC denotes and
T4332 6879-6887 NNP denotes Act-RIIb
T4333 6888-6891 VBP denotes are
T4334 6892-6901 VBN denotes expressed
T4335 6902-6904 IN denotes on
T4336 6905-6912 VBG denotes resting
T4337 6913-6918 JJ denotes human
T4338 6919-6926 NNS denotes B-cells
T4339 6927-6928 -LRB- denotes (
T4340 6928-6934 NN denotes Figure
T4341 6935-6936 CD denotes 4
T4342 6936-6937 -RRB- denotes )
T4343 6937-6938 . denotes .
T4344 6939-6944 NNP denotes Ramos
T4345 6945-6950 NNS denotes cells
T4346 6951-6960 VBD denotes expressed
T4347 6961-6964 DT denotes the
T4348 6965-6969 NN denotes type
T4349 6970-6971 PRP denotes I
T4350 6972-6981 NNS denotes receptors
T4351 6982-6989 NNP denotes Act-RIA
T4352 6989-6990 , denotes ,
T4353 6991-6997 RB denotes weakly
T4354 6998-7005 NNP denotes BMP-RIB
T4355 7006-7009 CC denotes and
T4356 7010-7013 DT denotes the
T4357 7014-7018 NN denotes type
T4358 7019-7021 NNP denotes II
T4359 7022-7030 NN denotes receptor
T4360 7031-7038 NNP denotes BMP-RII
T4361 7038-7039 , denotes ,
T4362 7040-7043 CC denotes but
T4363 7044-7048 RBR denotes more
T4364 7049-7055 RB denotes weakly
T4365 7056-7060 IN denotes than
T4366 7061-7067 JJ denotes normal
T4367 7068-7069 NNP denotes B
T4368 7070-7075 NNS denotes cells
T4369 7076-7077 -LRB- denotes (
T4370 7077-7083 NN denotes Figure
T4371 7084-7085 CD denotes 4
T4372 7085-7086 -RRB- denotes )
T4373 7086-7087 . denotes .
T4374 7088-7092 CD denotes HL60
T4375 7093-7098 NNS denotes cells
T4376 7099-7103 VBD denotes were
T4377 7104-7108 VBN denotes used
T4378 7109-7112 IN denotes for
T4379 7113-7123 NN denotes comparison
T4380 7124-7127 CC denotes and
T4381 7128-7134 RB denotes weakly
T4382 7135-7144 VBD denotes expressed
T4383 7145-7152 NNP denotes Act-RIA
T4384 7153-7156 CC denotes and
T4385 7157-7164 NNP denotes BMP-RII
T4386 7164-7165 . denotes .
T4387 7166-7171 VBN denotes Taken
T4388 7172-7180 RB denotes together
T4389 7180-7181 , denotes ,
T4390 7182-7187 DT denotes these
T4391 7188-7192 NNS denotes data
T4392 7193-7197 VBP denotes show
T4393 7198-7202 IN denotes that
T4394 7203-7209 JJ denotes normal
T4395 7210-7215 JJ denotes human
T4396 7216-7217 NNP denotes B
T4397 7218-7223 NNS denotes cells
T4398 7224-7227 CC denotes and
T4399 7228-7233 NNP denotes Ramos
T4400 7234-7239 NNS denotes cells
T4401 7240-7247 VBP denotes express
T4402 7248-7249 DT denotes a
T4403 7250-7253 NN denotes set
T4404 7254-7256 IN denotes of
T4405 7257-7260 NN denotes BMP
T4406 7261-7270 NNS denotes receptors
T4407 7270-7271 , denotes ,
T4408 7272-7282 RB denotes previously
T4409 7283-7288 VBN denotes shown
T4410 7289-7291 TO denotes to
T4411 7292-7296 NN denotes bind
T4412 7297-7302 NN denotes BMP-6
T4413 7303-7304 NNP denotes [
T4414 7304-7306 CD denotes 16
T4415 7306-7307 NNP denotes ]
T4416 7307-7308 . denotes .
T4892 7310-7315 CD denotes BMP-6
T4893 7316-7323 VBZ denotes induces
T4894 7324-7339 NN denotes phosphorylation
T4895 7340-7342 IN denotes of
T4896 7343-7352 NNP denotes Smad1/5/8
T4897 7353-7357 IN denotes Upon
T4898 7358-7364 JJ denotes ligand
T4899 7365-7372 JJ denotes binding
T4900 7372-7373 , denotes ,
T4901 7374-7377 DT denotes the
T4902 7378-7382 NN denotes type
T4903 7383-7385 NNP denotes II
T4904 7386-7394 NN denotes receptor
T4905 7395-7414 NNS denotes transphosphorylates
T4906 7415-7418 CC denotes and
T4907 7419-7428 VBZ denotes activates
T4908 7429-7432 DT denotes the
T4909 7433-7437 NN denotes type
T4910 7438-7439 PRP denotes I
T4911 7440-7448 NN denotes receptor
T4912 7448-7449 . denotes .
T4913 7450-7454 NN denotes Type
T4914 7455-7456 PRP denotes I
T4915 7457-7466 NNS denotes receptors
T4916 7467-7470 MD denotes can
T4917 7471-7477 VB denotes signal
T4918 7478-7481 IN denotes via
T4919 7482-7489 JJ denotes several
T4920 7490-7498 NNS denotes pathways
T4921 7498-7499 . denotes .
T4922 7500-7502 PRP denotes We
T4923 7503-7511 VBD denotes examined
T4924 7512-7515 DT denotes the
T4925 7516-7522 NN denotes effect
T4926 7523-7525 IN denotes of
T4927 7526-7531 NN denotes BMP-6
T4928 7532-7534 IN denotes on
T4929 7535-7539 NNP denotes Smad
T4930 7540-7555 NN denotes phosphorylation
T4931 7555-7556 , denotes ,
T4932 7557-7559 IN denotes as
T4933 7560-7563 DT denotes the
T4934 7564-7574 NN denotes activation
T4935 7575-7577 IN denotes of
T4936 7578-7582 NNP denotes Smad
T4937 7583-7585 VBZ denotes is
T4938 7586-7596 VBN denotes considered
T4939 7597-7599 TO denotes to
T4940 7600-7602 VB denotes be
T4941 7603-7604 DT denotes a
T4942 7605-7610 JJ denotes major
T4943 7611-7621 JJ denotes signalling
T4944 7622-7629 NN denotes pathway
T4945 7630-7633 IN denotes for
T4946 7634-7638 NNS denotes BMPs
T4947 7639-7640 NNP denotes [
T4948 7640-7642 CD denotes 17
T4949 7642-7643 NNP denotes ]
T4950 7643-7644 . denotes .
T4951 7645-7646 NNP denotes B
T4952 7647-7652 NNS denotes cells
T4953 7653-7657 VBD denotes were
T4954 7658-7666 VBN denotes cultured
T4955 7667-7669 IN denotes in
T4956 7670-7680 JJ denotes serum-free
T4957 7681-7686 NNS denotes media
T4958 7687-7691 IN denotes over
T4959 7692-7697 NN denotes night
T4960 7698-7701 CC denotes and
T4961 7702-7706 RB denotes then
T4962 7707-7714 VBN denotes treated
T4963 7715-7719 IN denotes with
T4964 7720-7725 NNP denotes BMP-6
T4965 7726-7729 IN denotes for
T4966 7730-7737 JJ denotes various
T4967 7738-7742 NN denotes time
T4968 7743-7749 NNS denotes points
T4969 7749-7750 . denotes .
T4970 7751-7756 JJ denotes Total
T4971 7757-7764 NN denotes protein
T4972 7765-7772 NNS denotes lysates
T4973 7773-7777 VBD denotes were
T4974 7778-7786 VBN denotes prepared
T4975 7786-7787 , denotes ,
T4976 7788-7791 CC denotes and
T4977 7792-7795 DT denotes the
T4978 7796-7803 NNS denotes amounts
T4979 7804-7806 IN denotes of
T4980 7807-7810 DT denotes the
T4981 7811-7825 JJ denotes phosphorylated
T4982 7826-7831 NNS denotes forms
T4983 7832-7834 IN denotes of
T4984 7835-7844 NNS denotes Smad1/5/8
T4985 7845-7849 VBD denotes were
T4986 7850-7860 VBN denotes determined
T4987 7861-7863 IN denotes by
T4988 7864-7871 JJ denotes western
T4989 7872-7876 NN denotes blot
T4990 7877-7885 NN denotes analysis
T4991 7885-7886 . denotes .
T4992 7887-7900 RB denotes Interestingly
T4993 7900-7901 , denotes ,
T4994 7902-7911 NN denotes treatment
T4995 7912-7916 IN denotes with
T4996 7917-7920 CD denotes 500
T4997 7921-7926 JJ denotes ng/ml
T4998 7927-7932 NN denotes BMP-6
T4999 7933-7940 VBD denotes induced
T5000 7941-7956 NN denotes phosphorylation
T5001 7957-7959 IN denotes of
T5002 7960-7964 NNP denotes Smad
T5003 7964-7965 . denotes .
T5004 7966-7969 DT denotes The
T5005 7970-7975 NNP denotes BMP-6
T5006 7976-7983 VBD denotes induced
T5007 7984-7999 NN denotes phosphorylation
T5008 8000-8003 VBD denotes was
T5009 8004-8008 JJ denotes high
T5010 8009-8011 IN denotes at
T5011 8012-8015 DT denotes the
T5012 8016-8024 JJS denotes earliest
T5013 8025-8029 NN denotes time
T5014 8030-8035 NN denotes point
T5015 8036-8042 VBN denotes tested
T5016 8043-8044 -LRB- denotes (
T5017 8044-8046 CD denotes 15
T5018 8047-8054 NNS denotes minutes
T5019 8054-8055 -RRB- denotes )
T5020 8055-8056 , denotes ,
T5021 8057-8060 CC denotes and
T5022 8061-8069 VBD denotes remained
T5023 8070-8074 JJ denotes high
T5024 8075-8078 IN denotes for
T5025 8079-8081 IN denotes at
T5026 8082-8087 JJS denotes least
T5027 8088-8090 CD denotes 48
T5028 8091-8096 NNS denotes hours
T5029 8097-8098 -LRB- denotes (
T5030 8098-8104 NN denotes Figure
T5031 8105-8106 CD denotes 5
T5032 8106-8107 -RRB- denotes )
T5033 8107-8108 . denotes .
T5034 8109-8110 DT denotes A
T5035 8111-8118 JJ denotes similar
T5036 8119-8134 NN denotes phosphorylation
T5037 8135-8138 VBD denotes was
T5038 8139-8147 VBN denotes observed
T5039 8148-8150 IN denotes in
T5040 8151-8156 NNP denotes Ramos
T5041 8157-8162 NNS denotes cells
T5042 8162-8163 , denotes ,
T5043 8164-8167 CC denotes but
T5044 8168-8171 RB denotes not
T5045 8172-8174 IN denotes in
T5046 8175-8179 CD denotes HL60
T5047 8180-8185 NNS denotes cells
T5048 8186-8187 -LRB- denotes (
T5049 8187-8193 NN denotes Figure
T5050 8194-8195 CD denotes 6
T5051 8195-8196 -RRB- denotes )
T5052 8196-8197 . denotes .
T5053 8198-8209 RB denotes Furthermore
T5054 8209-8210 , denotes ,
T5055 8211-8213 PRP denotes we
T5056 8214-8218 RB denotes also
T5057 8219-8225 VBD denotes tested
T5058 8226-8233 IN denotes whether
T5059 8234-8239 JJ denotes other
T5060 8240-8245 VBN denotes known
T5061 8246-8256 JJ denotes downstream
T5062 8257-8267 JJ denotes signalling
T5063 8268-8276 NNS denotes pathways
T5064 8277-8279 IN denotes of
T5065 8280-8285 NN denotes BMP-6
T5066 8286-8291 MD denotes could
T5067 8292-8294 VB denotes be
T5068 8295-8304 VBN denotes triggered
T5069 8305-8307 IN denotes by
T5070 8308-8313 NNP denotes BMP-6
T5071 8314-8316 IN denotes in
T5072 8317-8322 JJ denotes human
T5073 8323-8324 NNP denotes B
T5074 8325-8330 NNS denotes cells
T5075 8330-8331 . denotes .
T5076 8332-8339 RB denotes However
T5077 8339-8340 , denotes ,
T5078 8341-8343 PRP denotes we
T5079 8344-8347 VBD denotes did
T5080 8348-8351 RB denotes not
T5081 8352-8359 VB denotes observe
T5082 8360-8363 DT denotes any
T5083 8364-8375 JJ denotes significant
T5084 8376-8383 NNS denotes changes
T5085 8384-8386 IN denotes in
T5086 8387-8390 DT denotes the
T5087 8391-8396 NN denotes level
T5088 8397-8399 IN denotes of
T5089 8400-8413 JJ denotes phospho-STAT3
T5090 8414-8416 CC denotes or
T5091 8417-8428 JJ denotes phospho-p38
T5092 8429-8433 IN denotes upon
T5093 8434-8439 JJ denotes BMP-6
T5094 8440-8449 NN denotes treatment
T5095 8450-8452 IN denotes of
T5096 8453-8454 NNP denotes B
T5097 8455-8460 NNS denotes cells
T5098 8461-8462 -LRB- denotes (
T5099 8462-8466 NNS denotes data
T5100 8467-8470 RB denotes not
T5101 8471-8476 VBN denotes shown
T5102 8476-8477 -RRB- denotes )
T5103 8477-8478 . denotes .
T5850 8480-8485 CD denotes BMP-6
T5851 8486-8493 VBZ denotes induces
T5852 8494-8506 NN denotes upregulation
T5853 8507-8509 IN denotes of
T5854 8510-8513 NNP denotes Id1
T5855 8514-8518 NNP denotes Next
T5856 8518-8519 , denotes ,
T5857 8520-8522 PRP denotes we
T5858 8523-8529 VBD denotes wanted
T5859 8530-8532 TO denotes to
T5860 8533-8540 VB denotes explore
T5861 8541-8548 IN denotes whether
T5862 8549-8552 DT denotes the
T5863 8553-8558 NNP denotes BMP-6
T5864 8559-8566 VBD denotes induced
T5865 8567-8582 NN denotes phosphorylation
T5866 8583-8585 IN denotes of
T5867 8586-8590 NNP denotes Smad
T5868 8591-8596 CD denotes 1/5/8
T5869 8597-8601 RB denotes also
T5870 8602-8607 MD denotes could
T5871 8608-8614 VB denotes induce
T5872 8615-8630 JJ denotes transcriptional
T5873 8631-8638 NNS denotes changes
T5874 8639-8641 IN denotes of
T5875 8642-8648 NN denotes target
T5876 8649-8654 NNS denotes genes
T5877 8654-8655 . denotes .
T5878 8656-8658 IN denotes In
T5879 8659-8663 DT denotes this
T5880 8664-8670 NN denotes regard
T5881 8670-8671 , denotes ,
T5882 8672-8675 DT denotes the
T5883 8676-8686 NNS denotes inhibitors
T5884 8687-8689 IN denotes of
T5885 8690-8693 NNP denotes DNA
T5886 8694-8701 JJ denotes binding
T5887 8702-8710 NNS denotes proteins
T5888 8711-8712 -LRB- denotes (
T5889 8712-8715 NNP denotes Ids
T5890 8715-8716 -RRB- denotes )
T5891 8717-8720 VBP denotes are
T5892 8721-8731 VBN denotes considered
T5893 8732-8734 TO denotes to
T5894 8735-8737 VB denotes be
T5895 8738-8742 DT denotes some
T5896 8743-8745 IN denotes of
T5897 8746-8749 DT denotes the
T5898 8750-8755 JJ denotes major
T5899 8756-8762 NN denotes target
T5900 8763-8768 NNS denotes genes
T5901 8769-8772 IN denotes for
T5902 8773-8788 JJ denotes Smad-signalling
T5903 8789-8790 NNP denotes [
T5904 8790-8792 CD denotes 17
T5905 8792-8793 NNP denotes ]
T5906 8793-8794 . denotes .
T5907 8795-8799 RB denotes Thus
T5908 8799-8800 , denotes ,
T5909 8801-8802 NNP denotes B
T5910 8803-8808 NNS denotes cells
T5911 8809-8813 VBD denotes were
T5912 8814-8827 VBN denotes pre-incubated
T5913 8828-8832 IN denotes over
T5914 8833-8838 NN denotes night
T5915 8839-8841 IN denotes in
T5916 8842-8848 NNP denotes X-VIVO
T5917 8849-8851 CD denotes 15
T5918 8851-8852 , denotes ,
T5919 8853-8856 CC denotes and
T5920 8857-8861 RB denotes then
T5921 8862-8870 VBD denotes cultured
T5922 8871-8873 IN denotes in
T5923 8874-8880 NN denotes medium
T5924 8881-8886 RB denotes alone
T5925 8887-8889 CC denotes or
T5926 8890-8892 IN denotes in
T5927 8893-8896 DT denotes the
T5928 8897-8905 NN denotes presence
T5929 8906-8908 IN denotes of
T5930 8909-8914 NNP denotes BMP-6
T5931 8915-8918 IN denotes for
T5932 8919-8926 JJ denotes various
T5933 8927-8931 NN denotes time
T5934 8932-8938 NNS denotes points
T5935 8939-8945 IN denotes before
T5936 8946-8957 NN denotes preparation
T5937 8958-8960 IN denotes of
T5939 8967-8970 NNP denotes RNA
T5940 8970-8971 . denotes .
T5941 8972-8975 DT denotes The
T5942 8976-8982 NN denotes amount
T5943 8983-8985 IN denotes of
T5944 8986-8989 NNP denotes Id1
T5945 8990-8993 NNP denotes Id4
T5946 8994-8998 NNP denotes mRNA
T5947 8999-9002 VBD denotes was
T5948 9003-9013 VBN denotes quantified
T5949 9014-9016 IN denotes by
T5950 9017-9026 JJ denotes real-time
T5951 9027-9033 NN denotes RT-PCR
T5952 9033-9034 . denotes .
T5953 9035-9048 RB denotes Interestingly
T5954 9048-9049 , denotes ,
T5955 9050-9052 PRP denotes we
T5956 9053-9061 VBD denotes observed
T5957 9062-9063 DT denotes a
T5958 9064-9072 JJ denotes specific
T5959 9073-9082 RB denotes four-fold
T5960 9083-9095 NN denotes upregulation
T5961 9096-9098 IN denotes of
T5962 9099-9102 NNP denotes Id1
T5963 9103-9107 NNP denotes mRNA
T5964 9108-9110 IN denotes in
T5965 9111-9124 NNP denotes BMP-6-treated
T5966 9125-9126 NNP denotes B
T5967 9127-9132 NNS denotes cells
T5968 9133-9134 -LRB- denotes (
T5969 9134-9140 NN denotes Figure
T5970 9141-9142 CD denotes 7
T5971 9142-9143 -RRB- denotes )
T5972 9143-9144 . denotes .
T5973 9145-9148 DT denotes The
T5974 9149-9162 NN denotes up-regulation
T5975 9163-9165 IN denotes of
T5976 9166-9169 NNP denotes Id1
T5977 9170-9174 NNP denotes mRNA
T5978 9175-9178 VBD denotes was
T5979 9179-9193 JJ denotes characteristic
T5980 9194-9196 IN denotes of
T5981 9197-9199 DT denotes an
T5982 9200-9205 JJ denotes early
T5983 9206-9215 JJ denotes inducible
T5984 9216-9220 NN denotes gene
T5985 9220-9221 , denotes ,
T5986 9222-9226 IN denotes with
T5987 9227-9234 JJ denotes maximal
T5988 9235-9247 NN denotes upregulation
T5989 9248-9251 CD denotes two
T5990 9252-9257 NNS denotes hours
T5991 9258-9263 IN denotes after
T5992 9264-9267 DT denotes the
T5993 9268-9276 NN denotes addition
T5994 9277-9279 IN denotes of
T5995 9280-9285 NNP denotes BMP-6
T5996 9286-9289 CC denotes and
T5997 9290-9298 VBD denotes returned
T5998 9299-9301 TO denotes to
T5999 9302-9310 NN denotes baseline
T6000 9311-9316 IN denotes after
T6001 9317-9319 CD denotes 24
T6002 9320-9325 NNS denotes hours
T6003 9325-9326 . denotes .
T6004 9327-9329 IN denotes In
T6005 9330-9338 NN denotes contrast
T6006 9338-9339 , denotes ,
T6007 9340-9342 DT denotes no
T6008 9343-9354 JJ denotes significant
T6009 9355-9362 NNS denotes changes
T6010 9363-9367 VBD denotes were
T6011 9368-9376 VBN denotes observed
T6012 9377-9380 IN denotes for
T6013 9381-9384 NNP denotes Id2
T6014 9385-9388 CC denotes and
T6015 9389-9392 NNP denotes Id3
T6016 9393-9397 NNP denotes mRNA
T6017 9397-9398 , denotes ,
T6018 9399-9406 IN denotes whereas
T6019 9407-9422 NNS denotes Id4-transcripts
T6020 9423-9427 VBD denotes were
T6021 9428-9431 RB denotes not
T6022 9432-9442 JJ denotes detectable
T6023 9443-9444 -LRB- denotes (
T6024 9444-9450 NN denotes Figure
T6025 9451-9452 CD denotes 7
T6026 9452-9453 , denotes ,
T6027 9454-9458 NNS denotes data
T6028 9459-9462 RB denotes not
T6029 9463-9468 VBN denotes shown
T6030 9468-9469 -RRB- denotes )
T6031 9469-9470 . denotes .
T6032 9471-9478 JJ denotes Western
T6033 9479-9483 NN denotes blot
T6034 9484-9492 NN denotes analysis
T6035 9493-9501 VBD denotes revealed
T6036 9502-9506 IN denotes that
T6037 9507-9510 DT denotes the
T6038 9511-9524 JJ denotes BMP-6-induced
T6039 9525-9537 NN denotes upregulation
T6040 9538-9540 IN denotes of
T6041 9541-9544 NNP denotes Id1
T6042 9545-9549 NNP denotes mRNA
T6043 9550-9554 RB denotes also
T6044 9555-9558 VBD denotes was
T6045 9559-9569 VBN denotes correlated
T6046 9570-9574 IN denotes with
T6047 9575-9587 NN denotes upregulation
T6048 9588-9590 IN denotes of
T6049 9591-9594 JJ denotes Id1
T6050 9595-9602 NN denotes protein
T6051 9603-9605 RB denotes as
T6052 9606-9610 RB denotes well
T6053 9610-9611 . denotes .
T6054 9612-9615 DT denotes The
T6055 9616-9624 NN denotes increase
T6056 9625-9627 IN denotes in
T6057 9628-9631 JJ denotes Id1
T6058 9632-9639 NN denotes protein
T6059 9640-9645 NN denotes level
T6060 9646-9649 VBD denotes was
T6061 9650-9660 JJ denotes detectable
T6062 9661-9666 IN denotes after
T6063 9667-9670 CD denotes one
T6064 9671-9675 NN denotes hour
T6065 9676-9679 CC denotes and
T6066 9680-9689 VBD denotes increased
T6067 9690-9695 IN denotes until
T6068 9696-9698 CD denotes 24
T6069 9699-9704 NNS denotes hours
T6070 9705-9710 IN denotes after
T6071 9711-9716 NNP denotes BMP-6
T6072 9717-9725 NN denotes addition
T6073 9725-9726 , denotes ,
T6074 9727-9734 VBG denotes showing
T6075 9735-9736 DT denotes a
T6076 9737-9744 JJ denotes 16-fold
T6077 9745-9757 NN denotes upregulation
T6078 9758-9766 VBN denotes compared
T6079 9767-9771 IN denotes with
T6080 9772-9774 CD denotes t0
T6081 9775-9776 -LRB- denotes (
T6082 9776-9777 NN denotes p
T6083 9778-9779 NN denotes ≤
T6084 9780-9785 CD denotes 0.020
T6085 9785-9786 , denotes ,
T6086 9787-9788 VBP denotes n
T6087 9789-9790 SYM denotes =
T6088 9791-9792 LS denotes 4
T6089 9792-9793 -RRB- denotes )
T6090 9794-9795 -LRB- denotes (
T6091 9795-9801 NN denotes Figure
T6092 9802-9803 CD denotes 8
T6093 9804-9807 CC denotes and
T6094 9808-9809 CD denotes 9
T6095 9809-9810 -RRB- denotes )
T6096 9810-9811 . denotes .
T6097 9812-9814 IN denotes In
T6098 9815-9819 NN denotes line
T6099 9820-9824 IN denotes with
T6100 9825-9828 DT denotes the
T6101 9829-9833 NNP denotes mRNA
T6102 9834-9838 NNS denotes data
T6103 9838-9839 , denotes ,
T6104 9840-9842 DT denotes no
T6105 9843-9853 JJ denotes consistent
T6106 9854-9860 NN denotes change
T6107 9861-9863 IN denotes in
T6108 9864-9867 DT denotes the
T6109 9868-9875 NNS denotes amounts
T6110 9876-9878 IN denotes of
T6111 9879-9882 JJ denotes Id2
T6112 9883-9886 CC denotes and
T6113 9887-9890 JJ denotes Id3
T6114 9891-9898 NN denotes protein
T6115 9899-9904 MD denotes could
T6116 9905-9907 VB denotes be
T6117 9908-9916 VBN denotes observed
T6118 9917-9918 -LRB- denotes (
T6119 9918-9924 NN denotes Figure
T6120 9925-9926 CD denotes 8
T6121 9927-9930 CC denotes and
T6122 9931-9932 CD denotes 9
T6123 9932-9933 -RRB- denotes )
T6124 9933-9934 . denotes .
T6125 9935-9937 PRP denotes We
T6126 9938-9942 VBD denotes were
T6127 9943-9947 JJ denotes able
T6128 9948-9950 TO denotes to
T6129 9951-9956 VB denotes block
T6130 9957-9960 DT denotes the
T6131 9961-9964 JJ denotes Id1
T6132 9965-9973 JJ denotes specific
T6133 9974-9978 NN denotes band
T6134 9979-9983 IN denotes with
T6135 9984-9985 DT denotes a
T6136 9986-9994 VBG denotes blocking
T6137 9995-10002 NN denotes peptide
T6138 10003-10004 -LRB- denotes (
T6139 10004-10008 NNS denotes data
T6140 10009-10012 RB denotes not
T6141 10013-10018 VBN denotes shown
T6142 10018-10019 -RRB- denotes )
T6143 10019-10020 . denotes .
T6144 10021-10026 VBN denotes Taken
T6145 10027-10035 RB denotes together
T6146 10035-10036 , denotes ,
T6147 10037-10042 DT denotes these
T6148 10043-10047 NNS denotes data
T6149 10048-10055 VBP denotes suggest
T6150 10056-10060 IN denotes that
T6151 10061-10064 JJ denotes Id1
T6152 10065-10070 MD denotes could
T6153 10071-10073 VB denotes be
T6154 10074-10075 DT denotes a
T6155 10076-10084 JJ denotes possible
T6156 10085-10091 NN denotes target
T6157 10092-10096 NN denotes gene
T6158 10097-10100 IN denotes for
T6159 10101-10110 VBG denotes mediating
T6160 10111-10114 DT denotes the
T6161 10115-10122 NNS denotes effects
T6162 10123-10125 IN denotes of
T6163 10126-10131 NN denotes BMP-6
T6164 10132-10134 IN denotes in
T6165 10135-10140 JJ denotes human
T6166 10141-10142 NNP denotes B
T6167 10143-10148 NNS denotes cells
T6168 10148-10149 , denotes ,
T6169 10150-10157 IN denotes whereas
T6170 10158-10161 NNP denotes Id2
T6171 10162-10165 CC denotes and
T6172 10166-10169 NNP denotes Id3
T6173 10170-10173 RB denotes not
T6174 10174-10178 VBP denotes seem
T6175 10179-10181 TO denotes to
T6176 10182-10184 VB denotes be
T6177 10185-10193 VBN denotes involved
T6178 10193-10194 . denotes .
T6787 10196-10201 NN denotes BMP-6
T6788 10202-10212 NN denotes production
T6789 10213-10215 IN denotes in
T6790 10216-10217 NNP denotes B
T6791 10218-10223 NNS denotes cells
T6792 10224-10227 DT denotes The
T6793 10228-10232 NN denotes fact
T6794 10233-10237 IN denotes that
T6795 10238-10243 NNP denotes BMP-6
T6796 10244-10247 VBZ denotes has
T6797 10248-10252 VBN denotes been
T6798 10253-10261 VBN denotes reported
T6799 10262-10264 TO denotes to
T6800 10265-10268 VB denotes act
T6801 10269-10271 IN denotes as
T6802 10272-10274 DT denotes an
T6803 10275-10284 NN denotes autocrine
T6804 10285-10295 NN denotes stimulator
T6805 10296-10298 IN denotes in
T6806 10299-10311 NNS denotes chondrocytes
T6807 10312-10313 NNP denotes [
T6808 10313-10315 CD denotes 18
T6809 10315-10316 NNP denotes ]
T6810 10317-10320 CC denotes and
T6811 10321-10328 NN denotes ovarium
T6812 10329-10330 NNP denotes [
T6813 10330-10332 CD denotes 19
T6814 10332-10333 NNP denotes ]
T6815 10333-10334 , denotes ,
T6816 10335-10343 VBD denotes prompted
T6817 10344-10346 PRP denotes us
T6818 10347-10349 TO denotes to
T6819 10350-10361 VB denotes investigate
T6820 10362-10369 IN denotes whether
T6821 10370-10376 JJ denotes normal
T6822 10377-10382 JJ denotes human
T6823 10383-10384 NNP denotes B
T6824 10385-10390 NNS denotes cells
T6825 10391-10396 MD denotes could
T6826 10397-10404 VB denotes produce
T6827 10405-10410 NNP denotes BMP-6
T6828 10411-10415 IN denotes upon
T6829 10416-10427 NN denotes stimulation
T6830 10427-10428 . denotes .
T6831 10429-10434 NNP denotes Ramos
T6832 10435-10440 NNS denotes cells
T6833 10440-10441 , denotes ,
T6834 10442-10447 WDT denotes which
T6835 10448-10452 VBP denotes have
T6836 10453-10457 VBN denotes been
T6837 10458-10467 VBN denotes described
T6838 10468-10470 TO denotes to
T6839 10471-10478 VB denotes express
T6840 10479-10484 NNP denotes BMP-6
T6841 10485-10489 NNP denotes mRNA
T6842 10490-10502 RB denotes endogenously
T6843 10503-10504 NNP denotes [
T6844 10504-10506 CD denotes 20
T6845 10506-10507 NNP denotes ]
T6846 10507-10508 , denotes ,
T6847 10509-10512 CC denotes and
T6848 10513-10516 DT denotes the
T6849 10517-10518 NNP denotes T
T6850 10519-10523 NN denotes cell
T6851 10524-10528 NN denotes line
T6852 10529-10535 NNP denotes Jurkat
T6853 10535-10536 , denotes ,
T6854 10537-10543 VBD denotes served
T6855 10544-10546 IN denotes as
T6856 10547-10555 JJ denotes positive
T6857 10556-10559 CC denotes and
T6858 10560-10568 JJ denotes negative
T6859 10569-10577 NNS denotes controls
T6860 10577-10578 , denotes ,
T6861 10579-10591 RB denotes respectively
T6862 10591-10592 . denotes .
T6863 10593-10603 NNP denotes Endogenous
T6864 10604-10609 NNP denotes BMP-6
T6865 10610-10614 NNP denotes mRNA
T6866 10615-10621 NNS denotes levels
T6867 10622-10624 IN denotes in
T6868 10625-10631 JJ denotes normal
T6869 10632-10633 NNP denotes B
T6870 10634-10639 NNS denotes cells
T6871 10640-10644 VBD denotes were
T6872 10645-10655 VBN denotes quantified
T6873 10656-10658 IN denotes by
T6874 10659-10668 JJ denotes real-time
T6875 10669-10675 NN denotes RT-PCR
T6876 10676-10681 IN denotes after
T6877 10682-10693 NN denotes stimulation
T6878 10694-10698 IN denotes with
T6879 10699-10707 JJ denotes anti-IgM
T6880 10708-10711 IN denotes for
T6881 10712-10721 JJ denotes different
T6882 10722-10726 NN denotes time
T6883 10727-10733 NNS denotes points
T6884 10733-10734 . denotes .
T6885 10735-10748 RB denotes Interestingly
T6886 10748-10749 , denotes ,
T6887 10750-10753 DT denotes the
T6888 10754-10767 NN denotes up-regulation
T6889 10768-10770 IN denotes of
T6890 10771-10776 NNP denotes BMP-6
T6891 10777-10781 NNP denotes mRNA
T6892 10782-10785 VBD denotes was
T6893 10786-10800 JJ denotes characteristic
T6894 10801-10803 IN denotes of
T6895 10804-10806 DT denotes an
T6896 10807-10815 JJ denotes early-to
T6897 10816-10828 JJ denotes intermediate
T6898 10829-10838 JJ denotes inducible
T6899 10839-10843 NN denotes gene
T6900 10844-10848 IN denotes with
T6901 10849-10856 JJ denotes maximal
T6902 10857-10869 NN denotes upregulation
T6903 10870-10874 CD denotes four
T6904 10875-10880 NNS denotes hours
T6905 10881-10886 IN denotes after
T6906 10887-10890 DT denotes the
T6907 10891-10899 NN denotes addition
T6908 10900-10902 IN denotes of
T6909 10903-10911 JJ denotes anti-IgM
T6910 10911-10912 . denotes .
T6911 10913-10916 DT denotes The
T6912 10917-10922 NN denotes level
T6913 10923-10925 IN denotes of
T6914 10926-10931 NNP denotes BMP-6
T6915 10932-10936 NNP denotes mRNA
T6916 10937-10940 VBD denotes was
T6917 10941-10945 RB denotes back
T6918 10946-10948 TO denotes to
T6919 10949-10957 NN denotes baseline
T6920 10958-10963 IN denotes after
T6921 10964-10966 CD denotes 24
T6922 10967-10972 NNS denotes hours
T6923 10973-10977 IN denotes upon
T6924 10978-10989 NN denotes stimulation
T6925 10990-10991 -LRB- denotes (
T6926 10991-10997 NN denotes Figure
T6927 10998-11000 CD denotes 10
T6928 11000-11001 -RRB- denotes )
T6929 11001-11002 . denotes .
T6930 11003-11014 RB denotes Furthermore
T6931 11014-11015 , denotes ,
T6932 11016-11020 DT denotes both
T6933 11021-11024 NNP denotes FCS
T6934 11025-11028 CC denotes and
T6935 11029-11034 JJ denotes human
T6936 11035-11043 JJ denotes AB-serum
T6937 11044-11051 JJ denotes induced
T6938 11052-11063 JJ denotes significant
T6939 11064-11076 NN denotes upregulation
T6940 11077-11079 IN denotes of
T6941 11080-11085 NNP denotes BMP-6
T6942 11086-11090 NNP denotes mRNA
T6943 11091-11092 -LRB- denotes (
T6944 11092-11098 NNP denotes Figure
T6945 11099-11101 CD denotes 11
T6946 11101-11102 -RRB- denotes )
T6947 11102-11103 . denotes .
T6948 11104-11117 RB denotes Interestingly
T6949 11117-11118 , denotes ,
T6950 11119-11121 IN denotes in
T6951 11122-11123 DT denotes a
T6952 11124-11132 JJ denotes separate
T6953 11133-11138 NN denotes study
T6954 11139-11141 PRP denotes we
T6955 11142-11146 VBP denotes have
T6956 11147-11152 VBN denotes found
T6957 11153-11157 IN denotes that
T6958 11158-11164 JJ denotes normal
T6959 11165-11170 JJ denotes human
T6960 11171-11172 NNP denotes T
T6961 11173-11178 NNS denotes cells
T6962 11179-11181 VBP denotes do
T6963 11182-11185 RB denotes not
T6964 11186-11193 VB denotes express
T6965 11194-11199 NNP denotes BMP-6
T6966 11200-11204 NNP denotes mRNA
T6967 11205-11210 IN denotes after
T6968 11211-11221 NN denotes activation
T6969 11222-11223 -LRB- denotes (
T6970 11223-11232 NNP denotes Sivertsen
T6971 11233-11235 FW denotes et
T6972 11236-11238 FW denotes al
T6973 11238-11239 , denotes ,
T6974 11240-11250 NN denotes manuscript
T6975 11251-11253 IN denotes in
T6976 11254-11265 NN denotes preparation
T6977 11265-11266 -RRB- denotes )
T6978 11266-11267 . denotes .
T6979 11268-11272 JJ denotes Next
T6980 11272-11273 , denotes ,
T6981 11274-11276 PRP denotes we
T6982 11277-11283 VBD denotes wanted
T6983 11284-11286 TO denotes to
T6984 11287-11293 VB denotes detect
T6985 11294-11299 NNP denotes BMP-6
T6986 11300-11307 NN denotes protein
T6987 11308-11310 IN denotes in
T6988 11311-11317 JJ denotes normal
T6989 11318-11325 NNS denotes B-cells
T6990 11326-11329 CC denotes and
T6991 11330-11336 VBN denotes tested
T6992 11337-11344 JJ denotes various
T6993 11345-11357 RB denotes commercially
T6994 11358-11367 JJ denotes available
T6995 11368-11378 NNS denotes antibodies
T6996 11378-11379 . denotes .
T6997 11380-11387 RB denotes However
T6998 11387-11388 , denotes ,
T6999 11389-11391 IN denotes in
T7000 11392-11395 PRP$ denotes our
T7001 11396-11401 NNS denotes hands
T7002 11402-11407 DT denotes these
T7003 11408-11418 JJ denotes anti-BMP-6
T7004 11419-11429 NNS denotes antibodies
T7005 11430-11433 VBD denotes did
T7006 11434-11438 RB denotes only
T7007 11439-11448 VB denotes recognize
T7008 11449-11452 DT denotes the
T7009 11453-11464 JJ denotes recombinant
T7010 11465-11470 NNP denotes BMP-6
T7011 11471-11478 NN denotes protein
T7012 11479-11482 CC denotes and
T7013 11483-11486 RB denotes not
T7014 11487-11490 DT denotes the
T7015 11491-11497 JJ denotes native
T7016 11498-11505 NN denotes protein
T7017 11505-11506 . denotes .
T10324 11519-11525 JJ denotes Recent
T10325 11526-11533 NNS denotes studies
T10326 11534-11538 VBP denotes have
T10327 11539-11551 VBN denotes demonstrated
T10328 11552-11554 DT denotes an
T10329 11555-11564 JJ denotes important
T10330 11565-11569 NN denotes role
T10331 11570-11573 IN denotes for
T10332 11574-11577 NN denotes BMP
T10333 11578-11589 RB denotes superfamily
T10334 11590-11597 NNS denotes members
T10335 11598-11600 IN denotes in
T10336 11601-11614 JJ denotes hematopoietic
T10337 11615-11619 NN denotes stem
T10338 11620-11625 NNS denotes cells
T10339 11625-11626 , denotes ,
T10340 11627-11632 JJ denotes early
T10341 11633-11643 NNS denotes thymocytes
T10342 11644-11645 NNP denotes [
T10343 11645-11648 CD denotes 6,7
T10344 11648-11649 NNP denotes ]
T10345 11650-11653 CC denotes and
T10346 11654-11660 NNP denotes B-cell
T10347 11661-11673 NNS denotes malignancies
T10348 11674-11675 NNP denotes [
T10349 11675-11682 CD denotes 8,11,12
T10350 11682-11683 NNP denotes ]
T10351 11683-11684 , denotes ,
T10352 11685-11688 CC denotes but
T10353 11689-11690 DT denotes a
T10354 11691-11695 NN denotes role
T10355 11696-11699 IN denotes for
T10356 11700-11704 NNS denotes BMPs
T10357 11705-11707 IN denotes in
T10358 11708-11714 JJ denotes normal
T10359 11715-11720 JJ denotes human
T10360 11721-11722 NNP denotes B
T10361 11723-11728 NNS denotes cells
T10362 11729-11732 VBZ denotes has
T10363 11733-11743 RB denotes previously
T10364 11744-11747 RB denotes not
T10365 11748-11752 VBN denotes been
T10366 11753-11761 VBN denotes reported
T10367 11761-11762 . denotes .
T10368 11763-11766 DT denotes The
T10369 11767-11774 JJ denotes present
T10370 11775-11780 NN denotes study
T10371 11781-11793 VBD denotes demonstrated
T10372 11794-11795 DT denotes a
T10373 11796-11807 JJ denotes significant
T10374 11808-11825 JJ denotes antiproliferative
T10375 11826-11832 NN denotes effect
T10376 11833-11835 IN denotes of
T10377 11836-11841 NN denotes BMP-6
T10378 11842-11844 IN denotes in
T10379 11845-11855 JJ denotes peripheral
T10380 11856-11861 NN denotes blood
T10381 11862-11866 NNP denotes CD19
T10382 11866-11867 NNP denotes +
T10383 11868-11869 NNP denotes B
T10384 11870-11875 NNS denotes cells
T10385 11875-11876 . denotes .
T10386 11877-11889 RB denotes Additionally
T10387 11889-11890 , denotes ,
T10388 11891-11896 NNP denotes BMP-6
T10389 11897-11904 VBD denotes induced
T10390 11905-11909 NN denotes cell
T10391 11910-11915 NN denotes death
T10392 11916-11918 IN denotes in
T10393 11919-11923 NNP denotes CD27
T10394 11923-11924 NNP denotes +
T10395 11925-11931 NN denotes memory
T10396 11932-11933 NNP denotes B
T10397 11934-11939 NNS denotes cells
T10398 11940-11942 RB denotes as
T10399 11943-11947 RB denotes well
T10400 11948-11950 IN denotes as
T10401 11951-11953 IN denotes in
T10402 11954-11955 DT denotes a
T10403 11956-11963 NNP denotes Burkitt
T10404 11964-11972 NN denotes lymphoma
T10405 11973-11977 NN denotes cell
T10406 11978-11982 NN denotes line
T10407 11983-11984 -LRB- denotes (
T10408 11984-11989 NNP denotes Ramos
T10409 11989-11990 -RRB- denotes )
T10410 11990-11991 . denotes .
T10411 11992-12003 RB denotes Importantly
T10412 12003-12004 , denotes ,
T10413 12005-12010 NNP denotes BMP-6
T10414 12011-12018 VBD denotes induced
T10415 12019-12020 DT denotes a
T10416 12021-12026 JJ denotes rapid
T10417 12027-12030 CC denotes and
T10418 12031-12037 JJ denotes marked
T10419 12038-12046 NN denotes increase
T10420 12047-12049 IN denotes in
T10421 12050-12056 NNP denotes Smad-1
T10422 12056-12057 CD denotes /
T10423 12057-12060 CD denotes 5/8
T10424 12061-12076 NN denotes phosphorylation
T10425 12076-12077 . denotes .
T10426 12078-12089 RB denotes Furthermore
T10427 12089-12090 , denotes ,
T10428 12091-12094 DT denotes the
T10429 12095-12100 NNP denotes BMP-6
T10430 12101-12108 VBD denotes induced
T10431 12109-12113 NNP denotes Smad
T10432 12114-12129 NN denotes phosphorylation
T10433 12130-12133 VBD denotes was
T10434 12134-12142 VBN denotes followed
T10435 12143-12145 IN denotes by
T10436 12146-12147 DT denotes a
T10437 12148-12157 JJ denotes selective
T10438 12158-12170 NN denotes upregulation
T10439 12171-12173 IN denotes of
T10440 12174-12177 NNP denotes Id1
T10441 12178-12182 NNP denotes mRNA
T10442 12183-12186 CC denotes and
T10443 12187-12197 JJ denotes subsequent
T10444 12198-12201 JJ denotes Id1
T10445 12202-12209 NN denotes protein
T10446 12209-12210 . denotes .
T10447 12211-12213 IN denotes In
T10448 12214-12217 DT denotes the
T10449 12218-12225 JJ denotes present
T10450 12226-12231 NN denotes study
T10451 12231-12232 , denotes ,
T10452 12233-12236 DT denotes the
T10453 12237-12249 VBN denotes demonstrated
T10454 12250-12267 JJ denotes antiproliferative
T10455 12268-12274 NN denotes effect
T10456 12275-12277 IN denotes of
T10457 12278-12283 NN denotes BMP-6
T10458 12284-12286 IN denotes in
T10459 12287-12295 JJ denotes anti-IgM
T10460 12296-12303 VBN denotes treated
T10461 12304-12305 NNP denotes B
T10462 12306-12311 NNS denotes cells
T10463 12312-12315 VBD denotes was
T10464 12316-12327 JJ denotes significant
T10465 12328-12331 CC denotes and
T10466 12332-12346 JJ denotes dose-dependent
T10467 12346-12347 . denotes .
T10468 12348-12359 RB denotes Importantly
T10469 12359-12360 , denotes ,
T10470 12361-12364 DT denotes the
T10471 12365-12383 JJ denotes anti-proliferative
T10472 12384-12390 NN denotes effect
T10473 12391-12393 IN denotes of
T10474 12394-12399 NN denotes BMP-6
T10475 12400-12405 MD denotes could
T10476 12406-12408 VB denotes be
T10477 12409-12419 RB denotes completely
T10478 12420-12431 VBN denotes neutralized
T10479 12432-12434 IN denotes by
T10480 12435-12438 DT denotes the
T10481 12439-12442 NN denotes use
T10482 12443-12445 IN denotes of
T10483 12446-12447 DT denotes a
T10484 12448-12455 JJ denotes natural
T10485 12456-12465 NN denotes inhibitor
T10486 12465-12466 , denotes ,
T10487 12467-12473 NNP denotes Noggin
T10488 12473-12474 . denotes .
T10489 12475-12479 DT denotes This
T10490 12480-12482 VBZ denotes is
T10491 12483-12485 IN denotes in
T10492 12486-12490 NN denotes line
T10493 12491-12495 IN denotes with
T10494 12496-12502 NNS denotes others
T10495 12502-12503 , denotes ,
T10496 12504-12511 VBG denotes showing
T10497 12512-12516 IN denotes that
T10498 12517-12523 NNP denotes Noggin
T10499 12524-12527 MD denotes can
T10500 12528-12536 VB denotes function
T10501 12537-12539 IN denotes as
T10502 12540-12541 DT denotes a
T10503 12542-12547 NN denotes BMP-6
T10504 12548-12558 NN denotes antagonist
T10505 12559-12560 NNP denotes [
T10506 12560-12565 CD denotes 21,22
T10507 12565-12566 NNP denotes ]
T10508 12566-12567 . denotes .
T10509 12568-12570 IN denotes In
T10510 12571-12579 NN denotes addition
T10511 12579-12580 , denotes ,
T10512 12581-12584 DT denotes the
T10513 12585-12596 NN denotes combination
T10514 12597-12599 IN denotes of
T10515 12600-12607 JJ denotes soluble
T10516 12608-12618 JJ denotes BMP-RIB-Fc
T10517 12619-12622 CC denotes and
T10518 12623-12633 JJ denotes BMP-RII-Fc
T10519 12634-12640 NN denotes fusion
T10520 12641-12649 NNS denotes proteins
T10521 12650-12654 RB denotes also
T10522 12655-12666 VBD denotes neutralized
T10523 12667-12670 DT denotes the
T10524 12671-12689 JJ denotes anti-proliferative
T10525 12690-12696 NN denotes effect
T10526 12697-12699 IN denotes of
T10527 12700-12705 NN denotes BMP-6
T10528 12706-12708 IN denotes in
T10529 12709-12714 JJ denotes human
T10530 12715-12716 NNP denotes B
T10531 12717-12722 NNS denotes cells
T10532 12722-12723 . denotes .
T10533 12724-12737 RB denotes Interestingly
T10534 12737-12738 , denotes ,
T10535 12739-12741 IN denotes as
T10536 12742-12745 IN denotes for
T10537 12746-12751 JJ denotes other
T10538 12752-12755 NNP denotes TGF
T10539 12756-12762 NN denotes family
T10540 12763-12770 NNS denotes members
T10541 12770-12771 , denotes ,
T10542 12772-12784 JJ denotes bifunctional
T10543 12785-12792 NNS denotes effects
T10544 12793-12797 VBP denotes have
T10545 12798-12802 RB denotes also
T10546 12803-12807 VBN denotes been
T10547 12808-12820 VBN denotes demonstrated
T10548 12821-12824 IN denotes for
T10549 12825-12829 NNS denotes BMPs
T10550 12829-12830 . denotes .
T10551 12831-12838 IN denotes Whereas
T10552 12839-12846 JJ denotes several
T10553 12847-12849 IN denotes of
T10554 12850-12853 DT denotes the
T10555 12854-12858 NNS denotes BMPs
T10556 12859-12863 VBP denotes have
T10557 12864-12868 VBN denotes been
T10558 12869-12874 VBN denotes shown
T10559 12875-12877 TO denotes to
T10560 12878-12885 VB denotes promote
T10561 12886-12899 NN denotes proliferation
T10562 12900-12902 IN denotes in
T10563 12903-12910 JJ denotes various
T10564 12911-12915 NN denotes cell
T10565 12916-12921 NNS denotes types
T10566 12922-12931 VBG denotes including
T10567 12932-12943 NNS denotes condrocytes
T10568 12944-12945 NNP denotes [
T10569 12945-12947 CD denotes 23
T10570 12947-12948 NNP denotes ]
T10571 12948-12949 , denotes ,
T10572 12950-12955 NN denotes liver
T10573 12956-12957 NNP denotes [
T10574 12957-12959 CD denotes 24
T10575 12959-12960 NNP denotes ]
T10576 12961-12964 CC denotes and
T10577 12965-12974 NN denotes granulosa
T10578 12975-12980 NNS denotes cells
T10579 12981-12982 NNP denotes [
T10580 12982-12984 CD denotes 25
T10581 12984-12985 NNP denotes ]
T10582 12985-12986 , denotes ,
T10583 12987-13004 JJ denotes antiproliferative
T10584 13005-13012 NNS denotes effects
T10585 13013-13016 CC denotes and
T10586 13017-13026 NN denotes induction
T10587 13027-13029 IN denotes of
T10588 13030-13039 NN denotes apoptosis
T10589 13040-13043 VBZ denotes has
T10590 13044-13048 VBN denotes been
T10591 13049-13057 VBN denotes reported
T10592 13058-13061 IN denotes for
T10593 13062-13063 NNP denotes B
T10594 13064-13067 CC denotes and
T10595 13068-13069 NNP denotes T
T10596 13070-13077 NN denotes lineage
T10597 13078-13083 NNS denotes cells
T10598 13083-13084 . denotes .
T10599 13085-13092 JJ denotes Similar
T10600 13093-13100 NNS denotes effects
T10601 13101-13103 IN denotes as
T10602 13104-13116 VBN denotes demonstrated
T10603 13117-13120 IN denotes for
T10604 13121-13126 NN denotes BMP-6
T10605 13127-13129 IN denotes on
T10606 13130-13135 JJ denotes human
T10607 13136-13137 NNP denotes B
T10608 13138-13143 NNS denotes cells
T10609 13144-13146 IN denotes in
T10610 13147-13150 DT denotes the
T10611 13151-13158 JJ denotes present
T10612 13159-13164 NN denotes study
T10613 13164-13165 , denotes ,
T10614 13166-13170 VBD denotes were
T10615 13171-13183 VBN denotes demonstrated
T10616 13184-13187 IN denotes for
T10617 13188-13193 NNP denotes BMP-2
T10618 13193-13194 , denotes ,
T10619 13195-13196 CD denotes 4
T10620 13196-13197 , denotes ,
T10621 13198-13199 CD denotes 6
T10622 13200-13203 CC denotes and
T10623 13204-13206 CD denotes -7
T10624 13207-13209 IN denotes in
T10625 13210-13215 JJ denotes human
T10626 13216-13223 NN denotes myeloma
T10627 13224-13229 NNS denotes cells
T10628 13230-13231 NNP denotes [
T10629 13231-13235 CD denotes 9-11
T10630 13235-13236 NNP denotes ]
T10631 13236-13237 . denotes .
T10632 13238-13243 JJ denotes Other
T10633 13244-13251 NNS denotes members
T10634 13252-13254 IN denotes of
T10635 13255-13258 DT denotes the
T10636 13259-13269 NNP denotes BMP-family
T10637 13270-13274 VBP denotes have
T10638 13275-13279 RB denotes also
T10639 13280-13284 VBN denotes been
T10640 13285-13293 VBN denotes reported
T10641 13294-13296 TO denotes to
T10642 13297-13303 VB denotes induce
T10643 13304-13313 NN denotes apoptosis
T10644 13313-13314 , denotes ,
T10645 13315-13324 VBG denotes including
T10646 13325-13327 IN denotes in
T10647 13328-13333 NN denotes mouse
T10648 13334-13335 NNP denotes B
T10649 13336-13343 NN denotes lineage
T10650 13344-13349 NNS denotes cells
T10651 13350-13351 NNP denotes [
T10652 13351-13353 CD denotes 26
T10653 13353-13354 NNP denotes ]
T10654 13354-13355 . denotes .
T10655 13356-13368 RB denotes Additionally
T10656 13368-13369 , denotes ,
T10657 13370-13375 JJ denotes BMP-4
T10658 13376-13384 NNS denotes inhibits
T10659 13385-13394 VBP denotes thymocyte
T10660 13395-13408 NN denotes proliferation
T10661 13409-13410 NN denotes [
T10662 13410-13411 CD denotes 6
T10663 13411-13412 NNP denotes ]
T10664 13412-13413 . denotes .
T10665 13414-13419 VBN denotes Taken
T10666 13420-13428 RB denotes together
T10667 13428-13429 , denotes ,
T10668 13430-13435 DT denotes these
T10669 13436-13440 NNS denotes data
T10670 13441-13448 VBP denotes suggest
T10671 13449-13453 IN denotes that
T10672 13454-13457 DT denotes the
T10673 13458-13462 NN denotes role
T10674 13463-13465 IN denotes of
T10675 13466-13470 NNS denotes BMPs
T10676 13471-13473 IN denotes in
T10677 13474-13477 DT denotes the
T10678 13478-13488 NN denotes regulation
T10679 13489-13491 IN denotes of
T10680 13492-13505 NN denotes proliferation
T10681 13506-13509 CC denotes and
T10682 13510-13519 NN denotes apoptosis
T10683 13520-13522 VBZ denotes is
T10684 13523-13529 RB denotes highly
T10685 13530-13534 NN denotes cell
T10686 13535-13539 NN denotes type
T10687 13540-13549 JJ denotes dependent
T10688 13549-13550 . denotes .
T10689 13551-13553 TO denotes To
T10690 13554-13561 VB denotes examine
T10691 13562-13565 WRB denotes how
T10692 13566-13571 JJ denotes BMP-6
T10693 13572-13578 VBZ denotes exerts
T10694 13579-13582 PRP$ denotes its
T10695 13583-13593 JJ denotes functional
T10696 13594-13601 NNS denotes effects
T10697 13602-13604 IN denotes in
T10698 13605-13606 NNP denotes B
T10699 13607-13612 NNS denotes cells
T10700 13612-13613 , denotes ,
T10701 13614-13616 PRP denotes we
T10702 13617-13625 VBD denotes analysed
T10703 13626-13629 NN denotes BMP
T10704 13630-13638 NN denotes receptor
T10705 13639-13649 NN denotes expression
T10706 13650-13652 IN denotes by
T10707 13653-13660 JJ denotes western
T10708 13661-13665 NN denotes blot
T10709 13666-13674 NN denotes analysis
T10710 13674-13675 . denotes .
T10711 13676-13681 NNP denotes Human
T10712 13682-13692 JJ denotes peripheral
T10713 13693-13694 NNP denotes B
T10714 13695-13700 NNS denotes cells
T10715 13701-13705 VBD denotes were
T10716 13706-13711 VBN denotes found
T10717 13712-13714 TO denotes to
T10718 13715-13722 VB denotes express
T10719 13723-13726 DT denotes the
T10720 13727-13730 NN denotes BMP
T10721 13731-13735 NN denotes type
T10722 13736-13737 PRP denotes I
T10723 13738-13747 NNS denotes receptors
T10724 13748-13755 NNP denotes Act-RIA
T10725 13756-13759 CC denotes and
T10726 13760-13767 NNP denotes BMP-RIB
T10727 13767-13768 , denotes ,
T10728 13769-13772 CC denotes and
T10729 13773-13776 DT denotes the
T10730 13777-13781 NN denotes type
T10731 13782-13794 NNS denotes II-receptors
T10732 13795-13802 NNP denotes BMP-RII
T10733 13803-13806 CC denotes and
T10734 13807-13815 NNP denotes Act-RIIb
T10735 13815-13816 , denotes ,
T10736 13817-13822 WDT denotes which
T10737 13823-13829 VBP denotes signal
T10738 13830-13835 IN denotes after
T10739 13836-13843 JJ denotes binding
T10740 13844-13846 IN denotes of
T10741 13847-13854 JJ denotes several
T10742 13855-13859 NNS denotes BMPs
T10743 13859-13860 , denotes ,
T10744 13861-13870 VBG denotes including
T10745 13871-13876 NNP denotes BMP-6
T10746 13877-13878 NNP denotes [
T10747 13878-13883 CD denotes 16,13
T10748 13883-13884 NNP denotes ]
T10749 13884-13885 . denotes .
T10750 13886-13888 TO denotes To
T10751 13889-13896 RBR denotes further
T10752 13897-13904 VB denotes explore
T10753 13905-13910 NNP denotes BMP-6
T10754 13911-13918 JJ denotes induced
T10755 13919-13929 NN denotes signalling
T10756 13929-13930 , denotes ,
T10757 13931-13941 NN denotes activation
T10758 13942-13944 IN denotes of
T10759 13945-13952 JJ denotes several
T10760 13953-13961 NNS denotes pathways
T10761 13962-13964 VBZ denotes is
T10762 13965-13973 JJ denotes possible
T10763 13973-13974 . denotes .
T10764 13975-13978 DT denotes The
T10765 13979-13984 JJ denotes major
T10766 13985-13995 JJ denotes signalling
T10767 13996-14003 NN denotes pathway
T10768 14004-14009 VBN denotes known
T10769 14010-14012 TO denotes to
T10770 14013-14017 NN denotes date
T10771 14017-14018 , denotes ,
T10772 14019-14021 VBZ denotes is
T10773 14022-14032 NN denotes activation
T10774 14033-14035 IN denotes of
T10775 14036-14043 NNS denotes R-Smads
T10776 14044-14045 NNP denotes [
T10777 14045-14050 CD denotes 13,27
T10778 14050-14051 NNP denotes ]
T10779 14051-14052 . denotes .
T10780 14053-14055 IN denotes In
T10781 14056-14060 DT denotes that
T10782 14061-14068 NN denotes respect
T10783 14068-14069 , denotes ,
T10784 14070-14074 NNS denotes BMPs
T10785 14075-14079 VBP denotes have
T10786 14080-14084 VBN denotes been
T10787 14085-14090 VBN denotes shown
T10788 14091-14093 TO denotes to
T10789 14094-14099 VB denotes exert
T10790 14100-14117 JJ denotes antiproliferative
T10791 14118-14125 NNS denotes effects
T10792 14126-14128 IN denotes in
T10793 14129-14130 NNP denotes B
T10794 14131-14138 NN denotes lineage
T10795 14139-14144 NNS denotes cells
T10796 14145-14148 IN denotes via
T10797 14149-14164 NN denotes phosphorylation
T10798 14165-14167 IN denotes of
T10799 14168-14174 JJ denotes R-Smad
T10800 14175-14176 NNP denotes [
T10801 14176-14181 CD denotes 11,28
T10802 14181-14182 NNP denotes ]
T10803 14182-14183 . denotes .
T10804 14184-14195 RB denotes Furthermore
T10805 14195-14196 , denotes ,
T10806 14197-14202 NN denotes BMP-2
T10807 14203-14206 VBZ denotes has
T10808 14207-14211 VBN denotes been
T10809 14212-14217 VBN denotes shown
T10810 14218-14220 TO denotes to
T10811 14221-14227 VB denotes induce
T10812 14228-14238 NN denotes activation
T10813 14239-14241 IN denotes of
T10814 14242-14247 CD denotes STAT3
T10815 14248-14250 IN denotes in
T10816 14251-14258 NN denotes myeloma
T10817 14259-14264 NNS denotes cells
T10818 14265-14266 VBP denotes [
T10819 14266-14267 CD denotes 9
T10820 14267-14268 NNP denotes ]
T10821 14268-14269 . denotes .
T10822 14270-14277 RB denotes However
T10823 14277-14278 , denotes ,
T10824 14279-14294 NN denotes phosphorylation
T10825 14295-14297 IN denotes of
T10826 14298-14304 NN denotes R-Smad
T10827 14305-14308 VBD denotes was
T10828 14309-14312 RB denotes not
T10829 14313-14325 VBN denotes investigated
T10830 14326-14328 IN denotes in
T10831 14329-14333 DT denotes that
T10832 14334-14339 NN denotes study
T10833 14339-14340 . denotes .
T10834 14341-14346 NN denotes BMP-2
T10835 14347-14350 VBZ denotes has
T10836 14351-14355 RB denotes also
T10837 14356-14360 VBN denotes been
T10838 14361-14366 VBN denotes shown
T10839 14367-14369 TO denotes to
T10840 14370-14376 VB denotes induce
T10841 14377-14392 NN denotes phosphorylation
T10842 14393-14395 IN denotes of
T10843 14396-14399 CD denotes p38
T10844 14400-14401 NNP denotes [
T10845 14401-14403 CD denotes 29
T10846 14403-14404 NNP denotes ]
T10847 14404-14405 . denotes .
T10848 14406-14410 RB denotes Thus
T10849 14410-14411 , denotes ,
T10850 14412-14427 NN denotes phosphorylation
T10851 14428-14430 IN denotes of
T10852 14431-14434 CD denotes p38
T10853 14434-14435 , denotes ,
T10854 14436-14441 CD denotes STAT3
T10855 14442-14445 CC denotes and
T10856 14446-14455 CD denotes Smad1/5/8
T10857 14456-14465 VBP denotes represent
T10858 14466-14475 JJ denotes important
T10859 14476-14490 JJ denotes BMP-signalling
T10860 14491-14499 NNS denotes pathways
T10861 14500-14504 WDT denotes that
T10862 14505-14513 VBD denotes mediated
T10863 14514-14517 DT denotes the
T10864 14518-14525 NNS denotes effects
T10865 14526-14528 IN denotes of
T10866 14529-14533 NNS denotes BMPs
T10867 14534-14537 CC denotes and
T10868 14538-14542 RB denotes even
T10869 14543-14553 JJ denotes cross-talk
T10870 14554-14561 IN denotes between
T10871 14562-14567 DT denotes these
T10872 14568-14576 NNS denotes pathways
T10873 14577-14580 VBZ denotes has
T10874 14581-14585 VBN denotes been
T10875 14586-14594 VBN denotes reported
T10876 14595-14596 NNP denotes [
T10877 14596-14601 CD denotes 29,30
T10878 14601-14602 NNP denotes ]
T10879 14602-14603 . denotes .
T10880 14604-14606 IN denotes In
T10881 14607-14610 DT denotes the
T10882 14611-14618 JJ denotes present
T10883 14619-14624 NN denotes study
T10884 14624-14625 , denotes ,
T10885 14626-14628 PRP denotes we
T10886 14629-14633 VBD denotes were
T10887 14634-14637 RB denotes not
T10888 14638-14642 JJ denotes able
T10889 14643-14645 TO denotes to
T10890 14646-14652 VB denotes detect
T10891 14653-14666 JJ denotes BMP-6-induced
T10892 14667-14674 NNS denotes changes
T10893 14675-14677 IN denotes in
T10894 14678-14681 DT denotes the
T10895 14682-14697 NN denotes phosphorylation
T10896 14698-14704 NN denotes status
T10897 14705-14707 IN denotes of
T10898 14708-14713 CD denotes STAT3
T10899 14714-14716 CC denotes or
T10900 14717-14720 CD denotes p38
T10901 14721-14723 IN denotes in
T10902 14724-14729 JJ denotes human
T10903 14730-14740 JJ denotes peripheral
T10904 14741-14742 NNP denotes B
T10905 14743-14748 NNS denotes cells
T10906 14748-14749 . denotes .
T10907 14750-14757 RB denotes Instead
T10908 14757-14758 , denotes ,
T10909 14759-14760 DT denotes a
T10910 14761-14766 JJ denotes rapid
T10911 14767-14770 CC denotes and
T10912 14771-14777 JJ denotes marked
T10913 14778-14793 NN denotes phosphorylation
T10914 14794-14796 IN denotes of
T10915 14797-14806 NNP denotes Smad1/5/8
T10916 14807-14810 VBD denotes was
T10917 14811-14819 VBN denotes revealed
T10918 14819-14820 . denotes .
T10919 14821-14823 IN denotes In
T10920 14824-14825 DT denotes a
T10921 14826-14834 JJ denotes parallel
T10922 14835-14840 NN denotes study
T10923 14840-14841 , denotes ,
T10924 14842-14844 PRP denotes we
T10925 14845-14849 VBP denotes have
T10926 14850-14855 VBN denotes found
T10927 14856-14860 IN denotes that
T10928 14861-14866 JJ denotes other
T10929 14867-14871 NNS denotes BMPs
T10930 14872-14876 RB denotes also
T10931 14877-14884 VBD denotes induced
T10932 14885-14900 NN denotes phosphorylation
T10933 14901-14903 IN denotes of
T10934 14904-14913 NNP denotes Smad1/5/8
T10935 14914-14916 IN denotes in
T10936 14917-14927 JJ denotes peripheral
T10937 14928-14929 NNP denotes B
T10938 14930-14935 NNS denotes cells
T10939 14936-14937 -LRB- denotes (
T10940 14937-14941 NNS denotes data
T10941 14942-14945 RB denotes not
T10942 14946-14951 VBN denotes shown
T10943 14951-14952 -RRB- denotes )
T10944 14952-14953 . denotes .
T10945 14954-14956 PRP denotes We
T10946 14957-14960 VBP denotes are
T10947 14961-14970 RB denotes currently
T10948 14971-14979 VBG denotes pursuing
T10949 14980-14990 NN denotes microarray
T10950 14991-14998 NNS denotes studies
T10951 14999-15001 TO denotes to
T10952 15002-15010 VB denotes identify
T10953 15011-15014 DT denotes the
T10954 15015-15025 JJ denotes signalling
T10955 15026-15034 NNS denotes pathways
T10956 15035-15038 CC denotes and
T10957 15039-15045 NN denotes target
T10958 15046-15051 NNS denotes genes
T10959 15052-15056 WDT denotes that
T10960 15057-15060 VBP denotes are
T10961 15061-15072 RB denotes differently
T10962 15073-15082 VBN denotes regulated
T10963 15083-15085 IN denotes by
T10964 15086-15089 DT denotes the
T10965 15090-15097 JJ denotes various
T10966 15098-15102 NNS denotes BMPs
T10967 15103-15105 IN denotes in
T10968 15106-15111 JJ denotes human
T10969 15112-15113 NNP denotes B
T10970 15114-15119 NNS denotes cells
T10971 15119-15120 . denotes .
T10972 15121-15133 NNP denotes Upregulation
T10973 15134-15136 IN denotes of
T10974 15137-15140 NNP denotes Id1
T10975 15141-15144 IN denotes via
T10976 15145-15154 NNP denotes Smad1/5/8
T10977 15155-15170 NN denotes phosphorylation
T10978 15171-15173 VBZ denotes is
T10979 15174-15175 DT denotes a
T10980 15176-15181 JJ denotes known
T10981 15182-15191 NN denotes mechanism
T10982 15192-15195 IN denotes for
T10983 15196-15201 NNP denotes BMP-6
T10984 15202-15212 VBG denotes signalling
T10985 15213-15215 IN denotes in
T10986 15216-15221 JJ denotes other
T10987 15222-15226 NN denotes cell
T10988 15227-15234 NNS denotes systems
T10989 15235-15236 NNP denotes [
T10990 15236-15241 CD denotes 31,32
T10991 15241-15242 NNP denotes ]
T10992 15243-15246 CC denotes and
T10993 15247-15257 NN denotes regulation
T10994 15258-15260 IN denotes of
T10995 15261-15272 NNS denotes Id-proteins
T10996 15273-15275 VBZ denotes is
T10997 15276-15283 VBN denotes thought
T10998 15284-15286 TO denotes to
T10999 15287-15289 VB denotes be
T11000 15290-15292 DT denotes an
T11001 15293-15302 JJ denotes important
T11002 15303-15312 NN denotes mechanism
T11003 15313-15316 IN denotes for
T11004 15317-15332 JJ denotes Smad-signalling
T11005 15333-15334 NNP denotes [
T11006 15334-15336 CD denotes 17
T11007 15336-15337 NNP denotes ]
T11008 15337-15338 . denotes .
T11009 15339-15341 IN denotes In
T11010 15342-15345 DT denotes the
T11011 15346-15353 JJ denotes present
T11012 15354-15359 NN denotes study
T11013 15359-15360 , denotes ,
T11014 15361-15370 JJ denotes real-time
T11015 15371-15377 NN denotes RT-PCR
T11016 15378-15389 NNS denotes experiments
T11017 15390-15398 VBD denotes revealed
T11018 15399-15400 DT denotes a
T11019 15401-15409 JJ denotes specific
T11020 15410-15419 RB denotes four-fold
T11021 15420-15432 NN denotes upregulation
T11022 15433-15436 IN denotes for
T11023 15437-15440 NNP denotes Id1
T11024 15441-15443 IN denotes in
T11025 15444-15457 NNP denotes BMP-6-treated
T11026 15458-15459 NNP denotes B
T11027 15460-15465 NNS denotes cells
T11028 15465-15466 , denotes ,
T11029 15467-15472 IN denotes while
T11030 15473-15476 DT denotes the
T11031 15477-15483 NN denotes amount
T11032 15484-15486 IN denotes of
T11033 15487-15490 NNP denotes Id2
T11034 15491-15494 JJ denotes Id4
T11035 15495-15503 VBD denotes remained
T11036 15504-15513 JJ denotes unchanged
T11037 15513-15514 . denotes .
T11038 15515-15517 IN denotes In
T11039 15518-15527 NN denotes agreement
T11040 15528-15532 IN denotes with
T11041 15533-15537 DT denotes this
T11042 15537-15538 , denotes ,
T11043 15539-15546 JJ denotes western
T11044 15547-15551 NN denotes blot
T11045 15552-15560 NN denotes analysis
T11046 15561-15573 VBD denotes demonstrated
T11047 15574-15576 DT denotes an
T11048 15577-15589 NN denotes upregulation
T11049 15590-15592 IN denotes of
T11050 15593-15596 JJ denotes Id1
T11051 15597-15604 NN denotes protein
T11052 15604-15605 , denotes ,
T11053 15606-15611 IN denotes while
T11054 15612-15615 DT denotes the
T11055 15616-15622 NN denotes amount
T11056 15623-15625 IN denotes of
T11057 15626-15629 NNP denotes Id2
T11058 15630-15633 CC denotes and
T11059 15634-15637 NNP denotes Id3
T11060 15638-15645 NN denotes protein
T11061 15646-15652 NNS denotes levels
T11062 15653-15661 VBD denotes remained
T11063 15662-15671 JJ denotes unchanged
T11064 15671-15672 . denotes .
T11065 15673-15683 RB denotes Previously
T11066 15683-15684 , denotes ,
T11067 15685-15688 NNP denotes Id1
T11068 15689-15692 VBZ denotes has
T11069 15693-15697 VBN denotes been
T11070 15698-15708 VBN denotes considered
T11071 15709-15712 RB denotes not
T11072 15713-15715 TO denotes to
T11073 15716-15718 VB denotes be
T11074 15719-15728 VBN denotes expressed
T11075 15729-15731 IN denotes in
T11076 15732-15737 JJ denotes later
T11077 15738-15751 JJ denotes developmental
T11078 15752-15758 NNS denotes stages
T11079 15759-15763 IN denotes than
T11080 15764-15769 JJ denotes pro-B
T11081 15770-15775 NNS denotes cells
T11082 15776-15777 NNP denotes [
T11083 15777-15782 CD denotes 33,34
T11084 15782-15783 NNP denotes ]
T11085 15783-15784 , denotes ,
T11086 15785-15788 CC denotes and
T11087 15789-15792 PRP$ denotes its
T11088 15793-15805 JJ denotes constitutive
T11089 15806-15816 NN denotes expression
T11090 15817-15820 VBZ denotes has
T11091 15821-15825 VBN denotes been
T11092 15826-15834 VBN denotes reported
T11093 15835-15837 TO denotes to
T11094 15838-15844 VB denotes impair
T11095 15845-15850 NN denotes mouse
T11096 15851-15852 NNP denotes B
T11097 15853-15857 NN denotes cell
T11098 15858-15869 NN denotes development
T11099 15870-15871 NNP denotes [
T11100 15871-15873 CD denotes 35
T11101 15873-15874 NNP denotes ]
T11102 15874-15875 . denotes .
T11103 15876-15885 RB denotes Therefore
T11104 15885-15886 , denotes ,
T11105 15887-15890 PRP$ denotes our
T11106 15891-15904 NN denotes demonstration
T11107 15905-15907 IN denotes of
T11108 15908-15911 DT denotes the
T11109 15912-15926 JJ denotes time-dependent
T11110 15927-15939 NN denotes upregulation
T11111 15940-15942 IN denotes of
T11112 15943-15946 NNP denotes Id1
T11113 15947-15951 NNP denotes mRNA
T11114 15952-15955 CC denotes and
T11115 15956-15963 NN denotes protein
T11116 15964-15966 IN denotes in
T11117 15967-15973 JJ denotes mature
T11118 15974-15980 JJ denotes normal
T11119 15981-15986 JJ denotes human
T11120 15987-15988 NNP denotes B
T11121 15989-15994 NNS denotes cells
T11122 15995-15997 VBZ denotes is
T11123 15998-16000 IN denotes of
T11124 16001-16011 JJ denotes particular
T11125 16012-16020 NN denotes interest
T11126 16020-16021 . denotes .
T11127 16022-16024 IN denotes In
T11128 16025-16029 DT denotes that
T11129 16030-16037 NN denotes respect
T11130 16037-16038 , denotes ,
T11131 16039-16041 PRP denotes it
T11132 16042-16044 VBZ denotes is
T11133 16045-16055 JJ denotes noteworthy
T11134 16056-16060 IN denotes that
T11135 16061-16066 JJ denotes TGF-β
T11136 16067-16077 NN denotes signalling
T11137 16078-16080 IN denotes in
T11138 16081-16086 JJ denotes early
T11139 16087-16090 CC denotes and
T11140 16091-16097 JJ denotes mature
T11141 16098-16099 NNP denotes B
T11142 16100-16105 NNS denotes cells
T11143 16106-16113 VBZ denotes induces
T11144 16114-16118 DT denotes both
T11145 16119-16122 JJ denotes Id2
T11146 16123-16126 CC denotes and
T11147 16127-16130 JJ denotes Id3
T11148 16131-16141 NN denotes expression
T11149 16142-16143 NNP denotes [
T11150 16143-16148 CD denotes 36,37
T11151 16148-16149 NNP denotes ]
T11152 16149-16150 , denotes ,
T11153 16151-16154 CC denotes but
T11154 16155-16158 RB denotes not
T11155 16159-16162 JJ denotes Id1
T11156 16163-16164 -LRB- denotes (
T11157 16164-16168 NNS denotes data
T11158 16169-16172 RB denotes not
T11159 16173-16178 VBN denotes shown
T11160 16178-16179 -RRB- denotes )
T11161 16179-16180 . denotes .
T11162 16181-16194 RB denotes Interestingly
T11163 16194-16195 , denotes ,
T11164 16196-16201 DT denotes these
T11165 16202-16209 NNS denotes results
T11166 16210-16214 VBP denotes show
T11167 16215-16219 IN denotes that
T11168 16220-16227 JJ denotes various
T11169 16228-16235 NNS denotes members
T11170 16236-16238 IN denotes of
T11171 16239-16242 DT denotes the
T11172 16243-16248 NNP denotes TGF-β
T11173 16249-16255 NN denotes family
T11174 16256-16264 VB denotes regulate
T11175 16265-16267 NN denotes Id
T11176 16268-16276 NNS denotes proteins
T11177 16277-16288 RB denotes differently
T11178 16288-16289 . denotes .
T11179 16290-16293 NNP denotes Id2
T11180 16294-16297 CC denotes and
T11181 16298-16301 NNP denotes Id3
T11182 16302-16305 VBP denotes are
T11183 16306-16316 VBN denotes considered
T11184 16317-16319 TO denotes to
T11185 16320-16322 VB denotes be
T11186 16323-16326 DT denotes the
T11187 16327-16329 NN denotes Id
T11188 16330-16338 VBZ denotes proteins
T11189 16339-16345 RB denotes mainly
T11190 16346-16355 VBN denotes expressed
T11191 16356-16358 IN denotes in
T11192 16359-16365 JJ denotes mature
T11193 16366-16367 NNP denotes B
T11194 16368-16373 NNS denotes cells
T11195 16374-16375 NNP denotes [
T11196 16375-16377 CD denotes 38
T11197 16377-16378 NNP denotes ]
T11198 16378-16379 . denotes .
T11199 16380-16383 DT denotes The
T11200 16384-16391 JJ denotes present
T11201 16392-16397 NN denotes study
T11202 16398-16402 RB denotes also
T11203 16403-16408 VBD denotes found
T11204 16409-16412 NNP denotes Id2
T11205 16413-16416 CC denotes and
T11206 16417-16420 NNP denotes Id3
T11207 16421-16428 NN denotes protein
T11208 16429-16431 IN denotes in
T11209 16432-16433 NNP denotes B
T11210 16434-16439 NNS denotes cells
T11211 16440-16442 TO denotes to
T11212 16443-16445 VB denotes be
T11213 16446-16450 RBR denotes more
T11214 16451-16457 RB denotes highly
T11215 16458-16467 VBN denotes expressed
T11216 16468-16472 IN denotes than
T11217 16473-16476 JJ denotes Id1
T11218 16477-16479 IN denotes in
T11219 16480-16487 VBG denotes resting
T11220 16488-16489 NNP denotes B
T11221 16490-16495 NNS denotes cells
T11222 16495-16496 . denotes .
T11223 16497-16504 RB denotes However
T11224 16504-16505 , denotes ,
T11225 16506-16511 NNP denotes BMP-6
T11226 16512-16515 VBD denotes did
T11227 16516-16519 RB denotes not
T11228 16520-16526 VB denotes induce
T11229 16527-16538 JJ denotes significant
T11230 16539-16546 NNS denotes changes
T11231 16547-16549 IN denotes in
T11232 16550-16553 DT denotes the
T11233 16554-16561 NN denotes protein
T11234 16562-16572 NN denotes expression
T11235 16573-16575 IN denotes of
T11236 16576-16579 NNP denotes Id2
T11237 16580-16583 CC denotes and
T11238 16584-16587 NNP denotes Id3
T11239 16587-16588 . denotes .
T11240 16589-16591 PRP denotes It
T11241 16592-16594 VBZ denotes is
T11242 16595-16603 VBN denotes believed
T11243 16604-16608 IN denotes that
T11244 16609-16611 NN denotes Id
T11245 16612-16620 NNS denotes proteins
T11246 16621-16626 VBP denotes block
T11247 16627-16642 NN denotes differentiation
T11248 16643-16646 CC denotes and
T11249 16647-16654 VB denotes promote
T11250 16655-16668 NN denotes proliferation
T11251 16669-16671 IN denotes in
T11252 16672-16679 JJ denotes various
T11253 16680-16684 NN denotes cell
T11254 16685-16690 NNS denotes types
T11255 16691-16692 NNP denotes [
T11256 16692-16697 CD denotes 39,33
T11257 16697-16698 NNP denotes ]
T11258 16698-16699 . denotes .
T11259 16700-16702 NN denotes Id
T11260 16703-16711 NNS denotes proteins
T11261 16712-16715 VBP denotes act
T11262 16716-16718 IN denotes as
T11263 16719-16736 JJ denotes dominant-negative
T11264 16737-16747 NNS denotes inhibitors
T11265 16748-16750 IN denotes of
T11266 16751-16761 NNS denotes E-proteins
T11267 16762-16765 CC denotes and
T11268 16766-16770 NNS denotes Pax5
T11269 16771-16779 NN denotes function
T11270 16780-16782 IN denotes by
T11271 16783-16790 VBG denotes forming
T11272 16791-16797 NNS denotes dimers
T11273 16798-16802 IN denotes with
T11274 16803-16808 DT denotes these
T11275 16809-16817 NNS denotes proteins
T11276 16817-16818 , denotes ,
T11277 16819-16825 VBG denotes making
T11278 16826-16830 PRP denotes them
T11279 16831-16837 JJ denotes unable
T11280 16838-16840 TO denotes to
T11281 16841-16845 NN denotes bind
T11282 16846-16849 NN denotes DNA
T11283 16849-16850 . denotes .
T11284 16851-16853 PRP denotes It
T11285 16854-16857 VBZ denotes has
T11286 16858-16862 VBN denotes been
T11287 16863-16871 VBN denotes proposed
T11288 16872-16876 IN denotes that
T11289 16877-16880 DT denotes the
T11290 16881-16888 NN denotes balance
T11291 16889-16894 IN denotes among
T11292 16895-16905 NNS denotes E-proteins
T11293 16905-16906 , denotes ,
T11294 16907-16911 NNS denotes Pax5
T11295 16912-16915 CC denotes and
T11296 16916-16918 NN denotes Id
T11297 16919-16927 NNS denotes proteins
T11298 16928-16933 MD denotes might
T11299 16934-16938 VB denotes have
T11300 16939-16941 DT denotes an
T11301 16942-16951 JJ denotes important
T11302 16952-16956 NN denotes role
T11303 16957-16959 IN denotes in
T11304 16960-16969 VBN denotes activated
T11305 16970-16971 NNP denotes B
T11306 16972-16977 NNS denotes cells
T11307 16978-16979 NNP denotes [
T11308 16979-16981 CD denotes 38
T11309 16981-16982 NNP denotes ]
T11310 16982-16983 . denotes .
T11311 16984-16986 IN denotes In
T11312 16987-16991 DT denotes that
T11313 16992-16999 NN denotes respect
T11314 16999-17000 , denotes ,
T11315 17001-17011 NNS denotes E-proteins
T11316 17012-17016 VBP denotes have
T11317 17017-17021 VBN denotes been
T11318 17022-17032 VBN denotes implicated
T11319 17033-17035 IN denotes in
T11320 17036-17040 DT denotes both
T11321 17041-17044 DT denotes the
T11322 17045-17054 NN denotes promotion
T11323 17055-17058 CC denotes and
T11324 17059-17069 NN denotes inhibition
T11325 17070-17072 IN denotes of
T11326 17073-17077 NN denotes cell
T11327 17078-17086 NN denotes survival
T11328 17087-17090 CC denotes and
T11329 17091-17097 NN denotes growth
T11330 17098-17100 IN denotes at
T11331 17101-17110 JJ denotes different
T11332 17111-17117 NNS denotes points
T11333 17118-17120 IN denotes in
T11334 17121-17131 NN denotes lymphocyte
T11335 17132-17143 NN denotes development
T11336 17144-17145 NNP denotes [
T11337 17145-17147 CD denotes 40
T11338 17147-17148 NNP denotes ]
T11339 17148-17149 . denotes .
T11340 17150-17153 DT denotes The
T11341 17154-17171 JJ denotes antiproliferative
T11342 17172-17175 CC denotes and
T11343 17176-17181 NN denotes death
T11344 17182-17190 VBG denotes inducing
T11345 17191-17197 NN denotes effect
T11346 17198-17200 IN denotes of
T11347 17201-17206 NN denotes BMP-6
T11348 17207-17209 IN denotes in
T11349 17210-17211 NNP denotes B
T11350 17212-17217 NNS denotes cells
T11351 17218-17222 IN denotes with
T11352 17223-17234 JJ denotes concomitant
T11353 17235-17247 NN denotes upregulation
T11354 17248-17250 IN denotes of
T11355 17251-17254 JJ denotes Id1
T11356 17255-17262 NN denotes protein
T11357 17263-17265 VBZ denotes is
T11358 17266-17275 RB denotes therefore
T11359 17276-17278 IN denotes in
T11360 17279-17283 NN denotes line
T11361 17284-17288 IN denotes with
T11362 17289-17292 DT denotes the
T11363 17293-17297 NN denotes view
T11364 17298-17302 IN denotes that
T11365 17303-17305 NN denotes Id
T11366 17306-17314 NNS denotes proteins
T11367 17315-17318 VBP denotes are
T11368 17319-17327 VBN denotes required
T11369 17328-17331 IN denotes for
T11370 17332-17335 DT denotes the
T11371 17336-17345 NN denotes induction
T11372 17346-17348 IN denotes of
T11373 17349-17355 NN denotes growth
T11374 17356-17362 NN denotes arrest
T11375 17363-17366 CC denotes and
T11376 17367-17376 NN denotes apoptosis
T11377 17377-17379 IN denotes in
T11378 17380-17392 JJ denotes B-lymphocyte
T11379 17393-17404 NNS denotes progenitors
T11380 17405-17407 IN denotes by
T11381 17408-17413 NNP denotes TGF-β
T11382 17414-17415 NNP denotes [
T11383 17415-17417 CD denotes 40
T11384 17417-17418 NNP denotes ]
T11385 17418-17419 . denotes .
T11386 17420-17431 RB denotes Furthermore
T11387 17431-17432 , denotes ,
T11388 17433-17435 NN denotes Id
T11389 17436-17444 NNS denotes proteins
T11390 17445-17448 VBP denotes are
T11391 17449-17454 VBN denotes known
T11392 17455-17457 IN denotes as
T11393 17458-17467 JJ denotes important
T11394 17468-17473 NNS denotes parts
T11395 17474-17476 IN denotes of
T11396 17477-17487 VBG denotes signalling
T11397 17488-17496 NNS denotes pathways
T11398 17497-17505 VBN denotes involved
T11399 17506-17508 IN denotes in
T11400 17509-17520 NN denotes development
T11401 17520-17521 , denotes ,
T11402 17522-17526 NN denotes cell
T11403 17527-17532 NN denotes cycle
T11404 17533-17536 CC denotes and
T11405 17537-17550 NN denotes tumorigenesis
T11406 17551-17552 NNP denotes [
T11407 17552-17554 CD denotes 32
T11408 17554-17555 NNP denotes ]
T11409 17555-17556 . denotes .
T11410 17557-17559 PRP denotes It
T11411 17560-17562 VBZ denotes is
T11412 17563-17567 RB denotes well
T11413 17568-17579 VBN denotes established
T11414 17580-17584 IN denotes that
T11415 17585-17592 JJ denotes various
T11416 17593-17600 NNS denotes members
T11417 17601-17603 IN denotes of
T11418 17604-17607 DT denotes the
T11419 17608-17610 NN denotes Id
T11420 17611-17617 NN denotes family
T11421 17618-17621 VBP denotes are
T11422 17622-17635 VBN denotes overexpressed
T11423 17636-17638 IN denotes in
T11424 17639-17640 DT denotes a
T11425 17641-17646 NN denotes range
T11426 17647-17649 IN denotes of
T11427 17650-17655 JJ denotes human
T11428 17656-17663 NNS denotes tumours
T11429 17664-17667 CC denotes and
T11430 17668-17677 RB denotes generally
T11431 17677-17678 , denotes ,
T11432 17679-17682 JJ denotes Id1
T11433 17683-17690 VBZ denotes appears
T11434 17691-17693 TO denotes to
T11435 17694-17696 VB denotes be
T11436 17697-17700 DT denotes the
T11437 17701-17707 NN denotes family
T11438 17708-17714 NN denotes member
T11439 17715-17719 RBS denotes most
T11440 17720-17726 RB denotes widely
T11441 17727-17740 VBN denotes overexpressed
T11442 17741-17743 IN denotes in
T11443 17744-17745 DT denotes a
T11444 17746-17753 NN denotes variety
T11445 17754-17756 IN denotes of
T11446 17757-17762 JJ denotes human
T11447 17763-17775 NNS denotes malignancies
T11448 17776-17777 NNP denotes [
T11449 17777-17779 CD denotes 41
T11450 17779-17780 NNP denotes ]
T11451 17780-17781 , denotes ,
T11452 17782-17791 VBG denotes including
T11453 17792-17800 JJ denotes multiple
T11454 17801-17808 NN denotes myeloma
T11455 17809-17810 NNP denotes [
T11456 17810-17815 CD denotes 42,32
T11457 17815-17816 NNP denotes ]
T11458 17816-17817 . denotes .
T11459 17818-17830 RB denotes Additionally
T11460 17830-17831 , denotes ,
T11461 17832-17835 PRP$ denotes our
T11462 17836-17844 NNS denotes findings
T11463 17845-17849 WDT denotes that
T11464 17850-17855 NNP denotes BMP-6
T11465 17856-17865 VBZ denotes activates
T11466 17866-17879 JJ denotes intracellular
T11467 17880-17890 JJ denotes signalling
T11468 17891-17899 NNS denotes pathways
T11469 17900-17902 IN denotes in
T11470 17903-17908 JJ denotes human
T11471 17909-17910 NNP denotes B
T11472 17911-17916 NNS denotes cells
T11473 17917-17922 MD denotes might
T11474 17923-17925 VB denotes be
T11475 17926-17928 IN denotes of
T11476 17929-17938 JJ denotes potential
T11477 17939-17957 JJ denotes pathophysiological
T11478 17958-17970 NN denotes significance
T11479 17971-17973 IN denotes in
T11480 17974-17982 NN denotes lymphoma
T11481 17983-17986 CC denotes and
T11482 17987-17999 NN denotes inflammation
T11483 17999-18000 . denotes .
T11484 18001-18005 NNP denotes High
T11485 18006-18011 NNP denotes BMP-6
T11486 18012-18016 NNP denotes mRNA
T11487 18017-18027 NN denotes expression
T11488 18028-18030 IN denotes in
T11489 18031-18036 NNP denotes DLBCL
T11490 18037-18040 VBZ denotes has
T11491 18041-18045 VBN denotes been
T11492 18046-18051 VBN denotes shown
T11493 18052-18054 TO denotes to
T11494 18055-18064 VB denotes correlate
T11495 18065-18067 TO denotes to
T11496 18068-18080 JJ denotes unfavourable
T11497 18081-18088 NN denotes outcome
T11498 18089-18090 NNP denotes [
T11499 18090-18092 CD denotes 12
T11500 18092-18093 NNP denotes ]
T11501 18093-18094 . denotes .
T11502 18095-18097 IN denotes In
T11503 18098-18102 DT denotes this
T11504 18103-18110 NN denotes respect
T11505 18110-18111 , denotes ,
T11506 18112-18114 PRP denotes it
T11507 18115-18117 VBZ denotes is
T11508 18118-18120 IN denotes of
T11509 18121-18129 NN denotes interest
T11510 18130-18134 IN denotes that
T11511 18135-18143 JJ denotes targeted
T11512 18144-18154 NN denotes expression
T11513 18155-18157 IN denotes of
T11514 18158-18161 NNP denotes Id1
T11515 18162-18164 TO denotes to
T11516 18165-18178 NNS denotes B-lymphocytes
T11517 18179-18187 VBD denotes resulted
T11518 18188-18190 IN denotes in
T11519 18191-18199 JJ denotes aberrant
T11520 18200-18201 NNP denotes B
T11521 18202-18206 NN denotes cell
T11522 18207-18218 NN denotes development
T11523 18218-18219 , denotes ,
T11524 18220-18227 JJ denotes massive
T11525 18228-18237 NN denotes apoptosis
T11526 18237-18238 , denotes ,
T11527 18239-18242 CC denotes and
T11528 18243-18253 JJ denotes subsequent
T11529 18254-18265 NN denotes development
T11530 18266-18268 IN denotes of
T11531 18269-18270 NNP denotes B
T11532 18271-18275 NN denotes cell
T11533 18276-18285 NNS denotes lymphomas
T11534 18286-18287 NNP denotes [
T11555 18372-18377 CD denotes 43,44
T11556 18377-18378 NNP denotes ]
T11557 18379-18382 CC denotes and
T11558 18383-18391 JJ denotes elevated
T11559 18392-18398 NNS denotes levels
T11560 18399-18401 IN denotes of
T11561 18402-18405 NNP denotes Id1
T11562 18406-18409 CC denotes and
T11563 18410-18413 NNP denotes Id3
T11564 18414-18418 VBP denotes have
T11565 18419-18423 VBN denotes been
T11566 18424-18429 VBN denotes found
T11567 18430-18432 IN denotes in
T11568 18433-18436 DT denotes the
T11569 18437-18444 NN denotes synovia
T11570 18445-18447 IN denotes of
T11571 18448-18459 NNS denotes RA-patients
T11572 18460-18461 NNP denotes [
T11573 18461-18463 CD denotes 45
T11574 18463-18464 NNP denotes ]
T11575 18464-18465 . denotes .
T11576 18466-18476 RB denotes Altogether
T11577 18476-18477 , denotes ,
T11578 18478-18483 DT denotes these
T11579 18484-18491 NNS denotes results
T11580 18492-18497 NN denotes point
T11581 18498-18500 TO denotes to
T11582 18501-18503 DT denotes an
T11583 18504-18513 JJ denotes important
T11584 18514-18518 NN denotes role
T11585 18519-18522 IN denotes for
T11586 18523-18525 NN denotes Id
T11587 18526-18534 NNS denotes proteins
T11588 18535-18537 IN denotes in
T11589 18538-18541 DT denotes the
T11590 18542-18552 NN denotes regulation
T11591 18553-18555 IN denotes of
T11592 18556-18562 JJ denotes normal
T11593 18563-18564 NNP denotes B
T11594 18565-18569 NN denotes cell
T11595 18570-18581 NN denotes homeostasis
T11596 18582-18585 CC denotes and
T11597 18586-18588 IN denotes in
T11598 18589-18597 NNS denotes diseases
T11599 18597-18598 , denotes ,
T11600 18599-18604 WRB denotes where
T11601 18605-18606 NNP denotes B
T11602 18607-18612 NNS denotes cells
T11603 18613-18616 VBP denotes are
T11604 18617-18625 VBN denotes involved
T11605 18625-18626 . denotes .
T11606 18627-18629 PRP denotes It
T11607 18630-18634 MD denotes will
T11608 18635-18644 RB denotes therefore
T11609 18645-18647 VB denotes be
T11610 18648-18657 JJ denotes important
T11611 18658-18660 TO denotes to
T11612 18661-18668 RBR denotes further
T11613 18669-18678 VB denotes elucidate
T11614 18679-18682 DT denotes the
T11615 18683-18687 NN denotes role
T11616 18688-18690 IN denotes of
T11617 18691-18695 NN denotes Id-1
T11618 18696-18698 IN denotes in
T11619 18699-18704 JJ denotes human
T11620 18705-18706 NNP denotes B
T11621 18707-18712 NNS denotes cells
T11622 18713-18715 IN denotes by
T11623 18716-18725 JJ denotes selective
T11624 18726-18730 IN denotes over
T11625 18731-18741 NN denotes expression
T11626 18742-18744 CC denotes or
T11627 18745-18755 NN denotes inhibition
T11628 18756-18758 IN denotes of
T11629 18759-18763 JJ denotes Id-1
T11630 18764-18768 NN denotes gene
T11631 18769-18779 NN denotes expression
T11632 18779-18780 . denotes .
T11633 18781-18786 VBN denotes Given
T11634 18787-18790 DT denotes the
T11635 18791-18795 NN denotes role
T11636 18796-18798 IN denotes of
T11637 18799-18804 NNP denotes BMP-6
T11638 18805-18807 IN denotes in
T11639 18808-18814 NNP denotes mature
T11640 18815-18820 JJ denotes human
T11641 18821-18822 NNP denotes B
T11642 18823-18828 NNS denotes cells
T11643 18829-18841 VBD denotes demonstrated
T11644 18842-18846 RB denotes here
T11645 18846-18847 , denotes ,
T11646 18848-18862 NN denotes identification
T11647 18863-18865 IN denotes of
T11648 18866-18871 NNP denotes BMP-6
T11649 18872-18881 VBG denotes producing
T11650 18882-18887 NNS denotes cells
T11651 18888-18890 IN denotes in
T11652 18891-18895 NN denotes vivo
T11653 18896-18900 IN denotes with
T11654 18901-18912 NN denotes possibility
T11655 18913-18915 IN denotes of
T11656 18916-18927 NN denotes interaction
T11657 18928-18932 IN denotes with
T11658 18933-18938 NN denotes naïve
T11659 18939-18942 CC denotes and
T11660 18943-18949 NN denotes memory
T11661 18950-18951 NNP denotes B
T11662 18952-18957 NNS denotes cells
T11663 18958-18963 MD denotes might
T11664 18964-18974 VB denotes contribute
T11665 18975-18977 TO denotes to
T11666 18978-18981 DT denotes the
T11667 18982-18995 NN denotes understanding
T11668 18996-18998 IN denotes of
T11669 18999-19005 JJ denotes mature
T11670 19006-19007 NNP denotes B
T11671 19008-19012 NN denotes cell
T11672 19013-19020 NN denotes biology
T11673 19020-19021 . denotes .
T11674 19022-19026 NNP denotes High
T11675 19027-19032 NNP denotes BMP-6
T11676 19033-19037 NNP denotes mRNA
T11677 19038-19048 NN denotes expression
T11678 19049-19051 IN denotes in
T11679 19052-19057 NNP denotes DLBCL
T11680 19058-19061 VBZ denotes has
T11681 19062-19066 VBN denotes been
T11682 19067-19075 VBN denotes detected
T11683 19076-19078 IN denotes by
T11684 19079-19083 NN denotes gene
T11685 19084-19094 NN denotes expression
T11686 19095-19104 VBG denotes profiling
T11687 19105-19106 NNP denotes [
T11688 19106-19108 CD denotes 12
T11689 19108-19109 NNP denotes ]
T11690 19109-19110 . denotes .
T11691 19111-19122 RB denotes Furthermore
T11692 19122-19123 , denotes ,
T11693 19124-19134 NN denotes production
T11694 19135-19137 IN denotes of
T11695 19138-19143 NNP denotes BMP-6
T11696 19144-19155 NNS denotes transcripts
T11697 19156-19158 IN denotes in
T11698 19159-19165 JJ denotes normal
T11699 19166-19175 VBN denotes activated
T11700 19176-19177 NNP denotes B
T11701 19178-19183 NNS denotes cells
T11702 19184-19187 VBD denotes was
T11703 19188-19196 VBN denotes detected
T11704 19197-19199 IN denotes in
T11705 19200-19203 DT denotes the
T11706 19204-19208 JJ denotes same
T11707 19209-19214 NN denotes study
T11708 19214-19215 . denotes .
T11709 19216-19218 IN denotes Of
T11710 19219-19223 NN denotes note
T11742 19389-19394 NN denotes BMP-6
T11743 19395-19399 NN denotes loop
T11744 19400-19402 IN denotes in
T11745 19403-19408 JJ denotes human
T11746 19409-19410 NNP denotes B
T11747 19411-19416 NNS denotes cells
T11748 19416-19417 . denotes .
T11749 19418-19420 PRP denotes We
T11750 19421-19429 VBD denotes analysed
T11751 19430-19433 DT denotes the
T11752 19434-19444 NN denotes expression
T11753 19445-19450 NNP denotes BMP-6
T11754 19451-19455 NNP denotes mRNA
T11755 19456-19458 IN denotes in
T11756 19459-19469 JJ denotes peripheral
T11757 19470-19475 NN denotes blood
T11758 19476-19477 NNP denotes B
T11759 19478-19483 NNS denotes cells
T11760 19484-19486 IN denotes by
T11761 19487-19496 JJ denotes real-time
T11762 19497-19500 NNP denotes PCR
T11763 19500-19501 , denotes ,
T11764 19502-19505 CC denotes and
T11765 19506-19512 NN denotes report
T11766 19513-19517 RB denotes here
T11767 19518-19521 DT denotes the
T11768 19522-19534 NN denotes upregulation
T11769 19535-19537 IN denotes of
T11770 19538-19548 JJ denotes endogenous
T11771 19549-19554 NN denotes BMP-6
T11772 19555-19566 NNS denotes transcripts
T11773 19567-19572 IN denotes after
T11774 19573-19584 NN denotes stimulation
T11775 19585-19589 IN denotes with
T11776 19590-19593 NNP denotes FCS
T11777 19593-19594 , denotes ,
T11778 19595-19600 JJ denotes human
T11779 19601-19609 NNP denotes AB-serum
T11780 19610-19613 CC denotes and
T11781 19613-19614 , denotes ,
T11782 19615-19619 RBS denotes most
T11783 19620-19631 RB denotes importantly
T11784 19631-19632 , denotes ,
T11785 19633-19641 JJ denotes anti-IgM
T11786 19641-19642 . denotes .
T11787 19643-19650 RB denotes However
T11788 19650-19651 , denotes ,
T11789 19652-19655 PRP$ denotes our
T11790 19656-19664 NNS denotes attempts
T11791 19665-19667 TO denotes to
T11792 19668-19673 VB denotes study
T11793 19674-19679 NNP denotes BMP-6
T11794 19680-19687 NN denotes protein
T11795 19688-19694 NNS denotes levels
T11796 19695-19699 VBD denotes were
T11797 19700-19712 JJ denotes unsuccessful
T11798 19713-19716 JJ denotes due
T11799 19717-19719 TO denotes to
T11800 19720-19728 NNS denotes problems
T11801 19729-19733 IN denotes with
T11802 19734-19744 JJ denotes unspecific
T11803 19745-19752 JJ denotes binding
T11804 19753-19755 IN denotes of
T11805 19756-19759 DT denotes the
T11806 19760-19770 JJ denotes anti-BMP-6
T11807 19771-19781 NNS denotes antibodies
T11808 19782-19788 VBN denotes tested
T11809 19788-19789 , denotes ,
T11810 19790-19793 CC denotes and
T11811 19794-19798 NN denotes lack
T11812 19799-19801 IN denotes of
T11813 19802-19810 JJ denotes specific
T11814 19811-19819 VBG denotes staining
T11815 19820-19822 IN denotes in
T11816 19823-19830 NN denotes control
T11817 19831-19836 NNS denotes cells
T11818 19837-19842 VBN denotes known
T11819 19843-19845 TO denotes to
T11820 19846-19853 VB denotes express
T11821 19854-19859 NNP denotes BMP-6
T11822 19860-19864 NNP denotes mRNA
T11823 19864-19865 . denotes .
T11824 19866-19868 IN denotes In
T11825 19869-19877 NN denotes contrast
T11826 19877-19878 , denotes ,
T11827 19879-19882 DT denotes the
T11828 19883-19894 JJ denotes recombinant
T11829 19895-19902 NN denotes protein
T11830 19903-19906 VBD denotes was
T11831 19907-19914 RB denotes readily
T11832 19915-19923 VBN denotes detected
T11833 19923-19924 . denotes .
T11834 19925-19927 IN denotes In
T11835 19928-19932 DT denotes that
T11836 19933-19940 NN denotes respect
T11837 19940-19941 , denotes ,
T11838 19942-19945 JJ denotes few
T11839 19946-19959 NNS denotes investigators
T11840 19960-19964 VBP denotes have
T11841 19965-19973 VBN denotes detected
T11842 19974-19979 NNP denotes BMP-6
T11843 19980-19987 NN denotes protein
T11844 19988-19990 IN denotes in
T11845 19991-19997 NNS denotes humans
T11846 19997-19998 , denotes ,
T11847 19999-20009 RB denotes especially
T11848 20010-20012 IN denotes in
T11849 20013-20027 JJ denotes non-pathogenic
T11850 20028-20034 NN denotes tissue
T11851 20034-20035 . denotes .
T11852 20036-20039 DT denotes The
T11853 20040-20051 NN denotes possibility
T11854 20052-20054 IN denotes of
T11855 20055-20060 NN denotes BMP-6
T11856 20061-20071 NN denotes production
T11857 20072-20074 IN denotes in
T11858 20075-20080 JJ denotes human
T11859 20081-20088 NNPS denotes B-cells
T11860 20089-20091 VBZ denotes is
T11861 20092-20094 IN denotes in
T11862 20095-20099 NN denotes line
T11863 20100-20104 IN denotes with
T11864 20105-20106 DT denotes a
T11865 20107-20113 JJ denotes recent
T11866 20114-20118 NN denotes work
T11867 20119-20123 WDT denotes that
T11868 20124-20132 VBD denotes reported
T11869 20133-20136 DT denotes the
T11870 20137-20147 NN denotes production
T11871 20148-20150 IN denotes of
T11872 20151-20156 NN denotes BMP-6
T11873 20157-20159 IN denotes in
T11874 20160-20165 NN denotes mouse
T11875 20166-20167 NNP denotes B
T11876 20168-20173 NNS denotes cells
T11877 20173-20174 , denotes ,
T11878 20175-20187 VBG denotes infiltrating
T11879 20188-20191 DT denotes the
T11880 20192-20196 NN denotes bone
T11881 20197-20203 NN denotes marrow
T11882 20204-20206 IN denotes of
T11883 20207-20211 NNS denotes mice
T11884 20212-20216 IN denotes with
T11885 20217-20229 JJ denotes inflammatory
T11886 20230-20239 NNS denotes arthritis
T11887 20240-20241 NNP denotes [
T11888 20241-20243 CD denotes 43
T11889 20243-20244 NNP denotes ]
T11890 20244-20245 . denotes .
T11891 20246-20248 IN denotes In
T11892 20249-20253 DT denotes this
T11893 20254-20259 NN denotes study
T11894 20259-20260 , denotes ,
T11895 20261-20262 DT denotes a
T11896 20263-20267 NN denotes role
T11897 20268-20271 IN denotes for
T11898 20272-20276 NNS denotes BMPs
T11899 20277-20279 IN denotes in
T11900 20280-20283 DT denotes the
T11901 20284-20297 JJ denotes inflammatoric
T11902 20298-20305 NN denotes process
T11903 20306-20308 IN denotes of
T11904 20309-20318 NN denotes arthritis
T11905 20319-20322 VBD denotes was
T11906 20323-20332 VBN denotes suggested
T11907 20332-20333 . denotes .
T11908 20334-20337 DT denotes The
T11909 20338-20350 NN denotes upregulation
T11910 20351-20353 IN denotes of
T11911 20354-20357 DT denotes the
T11912 20358-20375 NNS denotes BMP-6-transcripts
T11913 20376-20381 IN denotes after
T11914 20382-20398 NNP denotes IgM-crosslinking
T11915 20399-20401 VBZ denotes is
T11916 20402-20404 IN denotes of
T11917 20405-20421 JJ denotes pathophysiologic
T11918 20422-20430 NN denotes interest
T11919 20431-20432 NNP denotes [
T11920 20432-20434 CD denotes 12
T11921 20434-20435 NNP denotes ]
T11922 20435-20436 . denotes .
T11923 20437-20438 DT denotes A
T11924 20439-20443 NN denotes loss
T11925 20444-20446 IN denotes of
T11926 20447-20467 NN denotes TGF-β-responsiveness
T11927 20468-20471 VBZ denotes has
T11928 20472-20476 VBN denotes been
T11929 20477-20486 VBN denotes suggested
T11930 20487-20489 TO denotes to
T11931 20490-20492 VB denotes be
T11932 20493-20494 DT denotes a
T11933 20495-20503 JJ denotes critical
T11934 20504-20516 NN denotes contribution
T11935 20517-20519 TO denotes to
T11936 20520-20529 JJ denotes malignant
T11937 20530-20544 NN denotes transformation
T11938 20545-20546 NNP denotes [
T11939 20546-20551 CD denotes 47,48
T11940 20551-20552 NNP denotes ]
T11941 20553-20556 CC denotes and
T11942 20557-20564 JJ denotes similar
T11943 20565-20574 JJ denotes oncogenic
T11944 20575-20585 NNS denotes mechanisms
T11945 20586-20590 VBP denotes have
T11946 20591-20595 VBN denotes been
T11947 20596-20606 VBN denotes postulated
T11948 20607-20610 IN denotes for
T11949 20611-20615 NNS denotes BMPs
T11950 20615-20616 . denotes .
T11951 20617-20622 NNS denotes Lines
T11952 20623-20625 IN denotes of
T11953 20626-20634 NN denotes evidence
T11954 20635-20642 VBP denotes suggest
T11955 20643-20644 NNP denotes [
T11956 20644-20646 CD denotes 49
T11957 20646-20647 NN denotes ]
T11958 20648-20652 WDT denotes that
T11959 20653-20655 IN denotes at
T11960 20656-20661 JJ denotes early
T11961 20662-20668 NNS denotes stages
T11962 20669-20671 IN denotes of
T11963 20672-20686 NN denotes carcinogenesis
T11964 20686-20687 , denotes ,
T11965 20688-20693 NNP denotes BMP-6
T11966 20694-20696 VBZ denotes is
T11967 20697-20700 RB denotes not
T11968 20701-20702 DT denotes a
T11969 20703-20709 NN denotes tumour
T11970 20710-20718 NN denotes promoter
T11971 20718-20719 , denotes ,
T11972 20720-20723 CC denotes but
T11973 20724-20734 VBZ denotes suppresses
T11974 20735-20741 JJ denotes benign
T11975 20742-20745 CC denotes and
T11976 20746-20755 JJ denotes malignant
T11977 20756-20762 NN denotes tumour
T11978 20763-20772 NN denotes outgrowth
T11979 20772-20773 . denotes .
T11980 20774-20779 DT denotes These
T11981 20780-20788 NNS denotes findings
T11982 20789-20792 VBP denotes are
T11983 20793-20795 IN denotes in
T11984 20796-20800 JJ denotes good
T11985 20801-20810 NN denotes agreement
T11986 20811-20815 IN denotes with
T11987 20816-20824 JJ denotes previous
T11988 20825-20833 NNS denotes findings
T11989 20834-20837 IN denotes for
T11990 20838-20843 JJ denotes other
T11991 20844-20849 NNP denotes TGF-β
T11992 20850-20856 NN denotes family
T11993 20857-20864 NNS denotes members
T11994 20864-20865 , denotes ,
T11995 20866-20875 VBG denotes including
T11996 20876-20882 NNP denotes TGF-β1
T11997 20883-20886 CC denotes and
T11998 20887-20892 NNP denotes BMP-4
T11999 20893-20894 NNP denotes [
T12000 20894-20896 CD denotes 50
T12001 20896-20897 NNP denotes ]
T12002 20897-20898 , denotes ,
T12003 20899-20909 VBG denotes indicating
T12004 20910-20914 IN denotes that
T12005 20915-20923 JJ denotes cellular
T12006 20924-20931 NN denotes context
T12007 20932-20934 IN denotes of
T12008 20935-20938 DT denotes the
T12009 20939-20942 NN denotes BMP
T12010 20943-20949 NN denotes target
T12011 20950-20954 NN denotes cell
T12012 20955-20960 MD denotes might
T12013 20961-20967 VB denotes define
T12014 20968-20971 DT denotes the
T12015 20972-20979 JJ denotes various
T12016 20980-20988 JJ denotes observed
T12017 20989-20996 NNS denotes effects
T12018 20996-20997 . denotes .
T12019 20998-21000 IN denotes In
T12020 21001-21009 NN denotes contrast
T12021 21010-21012 TO denotes to
T12022 21013-21016 DT denotes the
T12023 21017-21029 NN denotes upregulation
T12024 21030-21032 IN denotes of
T12025 21033-21038 NNP denotes BMP-6
T12026 21039-21049 NN denotes transcript
T12027 21050-21052 IN denotes in
T12028 21053-21054 NNP denotes B
T12029 21055-21060 NNS denotes cells
T12030 21060-21061 , denotes ,
T12031 21062-21064 PRP denotes we
T12032 21065-21069 VBD denotes were
T12033 21070-21073 RB denotes not
T12034 21074-21078 JJ denotes able
T12035 21079-21081 TO denotes to
T12036 21082-21088 VB denotes detect
T12037 21089-21094 NNP denotes BMP-6
T12038 21095-21106 NNS denotes transcripts
T12039 21107-21109 IN denotes in
T12040 21110-21115 JJ denotes human
T12041 21116-21126 JJ denotes peripheral
T12042 21127-21132 NN denotes blood
T12043 21133-21136 NNP denotes CD4
T12044 21136-21137 CD denotes +
T12045 21138-21140 CC denotes or
T12046 21141-21144 CD denotes CD8
T12047 21144-21145 CD denotes +
T12048 21146-21147 NNP denotes T
T12049 21148-21153 NNS denotes cells
T12050 21154-21155 -LRB- denotes (
T12051 21155-21162 VBG denotes resting
T12052 21163-21165 CC denotes or
T12053 21166-21176 VBN denotes stimulated
T12054 21177-21181 IN denotes with
T12055 21182-21190 JJ denotes anti-CD3
T12056 21191-21194 CC denotes and
T12057 21195-21204 JJ denotes anti-CD28
T12058 21204-21205 : denotes ;
T12059 21206-21210 NNS denotes data
T12060 21211-21214 RB denotes not
T12061 21215-21220 VBN denotes shown
T12062 21220-21221 -RRB- denotes )
T12063 21221-21222 , denotes ,
T12064 21223-21233 JJ denotes consistent
T12065 21234-21238 IN denotes with
T12066 21239-21242 DT denotes the
T12067 21243-21251 NNS denotes findings
T12068 21252-21254 IN denotes in
T12069 21255-21256 NNP denotes T
T12070 21257-21261 NN denotes cell
T12071 21262-21267 NNS denotes lines
T12072 21268-21269 NNP denotes [
T12073 21269-21271 CD denotes 20
T12074 21271-21272 NNP denotes ]
T12075 21273-21276 CC denotes and
T12076 21277-21278 NNP denotes T
T12077 21279-21284 NNS denotes cells
T12078 21285-21287 IN denotes in
T12079 21288-21292 NNS denotes mice
T12080 21293-21294 NNP denotes [
T12081 21294-21296 CD denotes 43
T12082 21296-21297 NNP denotes ]
T12083 21297-21298 . denotes .
T12084 21299-21304 JJ denotes Other
T12085 21305-21314 JJ denotes potential
T12086 21315-21320 NN denotes BMP-6
T12087 21321-21328 NNS denotes sources
T12088 21329-21332 IN denotes for
T12089 21333-21339 JJ denotes mature
T12090 21340-21341 NNP denotes B
T12091 21342-21347 NNS denotes cells
T12092 21348-21350 IN denotes in
T12093 21351-21355 NN denotes vivo
T12094 21356-21361 MD denotes might
T12095 21362-21364 VB denotes be
T12096 21365-21370 JJ denotes other
T12097 21371-21376 NNS denotes cells
T12098 21377-21379 IN denotes of
T12099 21380-21383 DT denotes the
T12100 21384-21390 JJ denotes immune
T12101 21391-21397 NN denotes system
T12119 21501-21504 DT denotes the
T12120 21505-21510 JJ denotes human
T12121 21511-21515 NN denotes bone
T12122 21516-21519 CC denotes and
T12123 21520-21524 NN denotes bone
T12124 21525-21531 NN denotes marrow
T12125 21532-21538 NN denotes stroma
T12126 21539-21540 NNP denotes [
T12127 21540-21544 CD denotes 51,8
T12128 21544-21545 NNP denotes ]
T12129 21545-21546 . denotes .
T12130 21547-21558 RB denotes Furthermore
T12131 21558-21559 , denotes ,
T12132 21560-21562 PRP denotes it
T12133 21563-21565 VBZ denotes is
T12134 21566-21576 JJ denotes noteworthy
T12135 21577-21581 IN denotes that
T12136 21582-21587 JJ denotes human
T12137 21588-21597 JJ denotes umbilical
T12138 21598-21602 NN denotes vein
T12139 21603-21614 JJ denotes endothelial
T12140 21615-21620 NNS denotes cells
T12141 21621-21622 -LRB- denotes (
T12142 21622-21627 NNP denotes HUVEC
T12143 21627-21628 -RRB- denotes )
T12144 21629-21635 RB denotes highly
T12145 21636-21643 JJ denotes express
T12146 21644-21649 NNP denotes BMP-6
T12147 21650-21654 NNP denotes mRNA
T12148 21655-21656 NNP denotes [
T12149 21656-21658 CD denotes 52
T12150 21658-21659 NNP denotes ]
T12151 21659-21660 , denotes ,
T12152 21661-21664 CC denotes and
T12153 21665-21673 JJ denotes vascular
T12154 21674-21685 NN denotes endothelium
T12155 21686-21689 VBZ denotes has
T12156 21690-21694 VBN denotes been
T12157 21695-21703 VBN denotes reported
T12158 21704-21706 TO denotes to
T12159 21707-21714 VB denotes produce
T12160 21715-21720 NNP denotes BMP-6
T12161 21721-21722 NNP denotes [
T12162 21722-21724 CD denotes 53
T12163 21724-21725 NNP denotes ]
T12164 21725-21726 . denotes .
T12165 21727-21732 DT denotes These
T12166 21733-21740 NNS denotes studies
T12167 21741-21746 MD denotes might
T12168 21747-21752 VB denotes imply
T12169 21753-21754 DT denotes a
T12170 21755-21759 NN denotes role
T12171 21760-21763 IN denotes for
T12172 21764-21769 NNP denotes BMP-6
T12173 21770-21772 IN denotes in
T12174 21773-21789 JJ denotes transendothelial
T12175 21790-21799 NN denotes migration
T12176 21800-21802 IN denotes of
T12177 21803-21804 NNP denotes B
T12178 21805-21810 NNS denotes cells
T12179 21810-21811 . denotes .
T12180 21812-21817 CD denotes BMP-6
T12181 21818-21822 NNP denotes mRNA
T12182 21823-21826 VBZ denotes has
T12183 21827-21831 VBN denotes been
T12184 21832-21844 VBN denotes demonstrated
T12185 21845-21847 IN denotes in
T12186 21848-21854 NN denotes murine
T12187 21855-21865 NN denotes macrophage
T12188 21866-21870 NN denotes cell
T12189 21871-21876 NNS denotes lines
T12190 21876-21877 , denotes ,
T12191 21878-21881 CC denotes but
T12192 21882-21885 RB denotes not
T12193 21886-21888 IN denotes in
T12194 21889-21895 NNS denotes humans
T12195 21896-21897 NNP denotes [
T12196 21897-21899 CD denotes 54
T12197 21899-21900 NNP denotes ]
T12198 21900-21901 . denotes .
T12199 21902-21904 IN denotes In
T12200 21905-21915 NN denotes accordance
T12201 21916-21920 IN denotes with
T12202 21921-21926 DT denotes these
T12203 21927-21935 NNS denotes findings
T12204 21935-21936 , denotes ,
T12205 21937-21942 JJ denotes other
T12206 21943-21948 JJ denotes human
T12207 21949-21953 NN denotes cell
T12208 21954-21959 NNS denotes lines
T12209 21960-21962 IN denotes of
T12210 21963-21973 NN denotes neutrophil
T12211 21974-21977 CC denotes and
T12212 21978-21987 JJ denotes monocytic
T12213 21988-21994 NN denotes origin
T12214 21995-21999 VBP denotes have
T12215 22000-22004 VBN denotes been
T12216 22005-22014 VBN denotes described
T12217 22015-22017 TO denotes to
T12218 22018-22020 VB denotes be
T12219 22021-22029 JJ denotes negative
T12220 22030-22033 IN denotes for
T12221 22034-22037 DT denotes the
T12222 22038-22043 NNP denotes BMP-6
T12223 22044-22054 NN denotes transcript
T12224 22055-22056 NNP denotes [
T12225 22056-22058 CD denotes 20
T12226 22058-22059 NNP denotes ]
T12227 22059-22060 . denotes .
T12228 22061-22063 TO denotes To
T12229 22064-22067 PRP$ denotes our
T12230 22068-22077 NN denotes knowledge
T12231 22077-22078 , denotes ,
T12232 22079-22084 EX denotes there
T12233 22085-22087 VBZ denotes is
T12234 22088-22097 RB denotes currently
T12235 22098-22100 DT denotes no
T12236 22101-22107 NN denotes report
T12237 22108-22113 IN denotes about
T12238 22114-22119 NN denotes BMP-6
T12239 22120-22130 NN denotes production
T12240 22131-22133 IN denotes of
T12241 22134-22139 JJ denotes human
T12242 22140-22149 JJ denotes dendritic
T12243 22150-22155 NNS denotes cells
T12244 22155-22156 . denotes .
T13536 22169-22171 IN denotes In
T13537 22172-22182 NN denotes conclusion
T13538 22182-22183 , denotes ,
T13539 22184-22187 PRP$ denotes our
T13540 22188-22195 NNS denotes results
T13541 22196-22200 VBP denotes show
T13542 22201-22205 IN denotes that
T13543 22206-22211 NNP denotes BMP-6
T13544 22212-22219 VBZ denotes induces
T13545 22220-22230 NN denotes activation
T13546 22231-22233 IN denotes of
T13547 22234-22247 JJ denotes intracellular
T13548 22248-22252 NNP denotes Smad
T13549 22253-22263 NN denotes signalling
T13550 22264-22266 IN denotes in
T13551 22267-22273 JJ denotes mature
T13552 22274-22279 JJ denotes human
T13553 22280-22287 NNS denotes B-cells
T13554 22288-22292 IN denotes with
T13555 22293-22304 JJ denotes consecutive
T13556 22305-22315 NN denotes production
T13557 22316-22318 IN denotes of
T13558 22319-22322 JJ denotes Id1
T13559 22323-22330 NN denotes protein
T13560 22330-22331 . denotes .
T13561 22332-22343 RB denotes Furthermore
T13562 22343-22344 , denotes ,
T13563 22345-22347 PRP denotes we
T13564 22348-22354 VBP denotes report
T13565 22355-22359 IN denotes that
T13566 22360-22365 NNP denotes BMP-6
T13567 22366-22369 VBZ denotes has
T13568 22370-22372 DT denotes an
T13569 22373-22390 JJ denotes antiproliferative
T13570 22391-22397 NN denotes effect
T13571 22398-22400 IN denotes in
T13572 22401-22402 NNP denotes B
T13573 22403-22408 NNS denotes cells
T13574 22409-22419 VBN denotes stimulated
T13575 22420-22424 IN denotes with
T13576 22425-22433 JJ denotes anti-IgM
T13577 22434-22439 RB denotes alone
T13578 22440-22442 CC denotes or
T13579 22443-22446 DT denotes the
T13580 22447-22455 VBN denotes combined
T13581 22456-22462 NN denotes action
T13582 22463-22465 IN denotes of
T13583 22466-22474 JJ denotes anti-IgM
T13584 22475-22478 CC denotes and
T13585 22479-22484 NNP denotes CD40L
T13586 22484-22485 . denotes .
T13587 22486-22498 RB denotes Additionally
T13588 22498-22499 , denotes ,
T13589 22500-22505 NNP denotes BMP-6
T13590 22506-22513 VBZ denotes induces
T13591 22514-22518 NN denotes cell
T13592 22519-22524 NN denotes death
T13593 22525-22527 IN denotes in
T13594 22528-22537 VBN denotes activated
T13595 22538-22544 NN denotes memory
T13596 22545-22546 NNP denotes B
T13597 22547-22552 NNS denotes cells
T13598 22553-22556 CC denotes and
T13599 22557-22562 NNP denotes Ramos
T13600 22563-22568 NNS denotes cells
T13601 22568-22569 . denotes .
T13602 22570-22575 VBN denotes Taken
T13603 22576-22584 RB denotes together
T13604 22584-22585 , denotes ,
T13605 22586-22591 DT denotes these
T13606 22592-22599 NNS denotes results
T13622 22685-22692 NN denotes biology
T13623 22693-22695 RB denotes as
T13624 22696-22700 RB denotes well
T13625 22701-22703 IN denotes as
T13626 22704-22706 IN denotes in
T13627 22707-22717 JJ denotes pathologic
T13628 22718-22728 NNS denotes conditions
T13629 22729-22733 IN denotes like
T13630 22734-22735 NNP denotes B
T13631 22736-22740 NN denotes cell
T13632 22741-22753 NNS denotes malignancies
T13633 22754-22757 CC denotes and
T13634 22758-22768 JJ denotes autoimmune
T13635 22769-22778 NNS denotes disorders
T13636 22778-22779 . denotes .
T13907 22790-22794 NNP denotes Cell
T13908 22795-22802 NN denotes culture
T13909 22803-22805 IN denotes If
T13910 22806-22809 RB denotes not
T13911 22810-22819 VBN denotes specified
T13912 22819-22820 , denotes ,
T13913 22821-22824 DT denotes all
T13914 22825-22830 NNS denotes cells
T13915 22831-22835 VBD denotes were
T13916 22836-22844 VBN denotes cultured
T13917 22845-22847 IN denotes in
T13918 22848-22854 NNP denotes X-VIVO
T13919 22855-22857 CD denotes 15
T13920 22857-22858 NN denotes ™
T13921 22859-22860 -LRB- denotes (
T13922 22860-22872 NNP denotes BioWhittaker
T13923 22872-22873 , denotes ,
T13924 22874-22882 NNP denotes Verviers
T13925 22882-22883 , denotes ,
T13926 22884-22891 NNP denotes Belgium
T13927 22891-22892 -RRB- denotes )
T13928 22893-22903 JJ denotes serum-free
T13929 22904-22910 NN denotes medium
T13930 22911-22913 IN denotes at
T13931 22914-22916 CD denotes 37
T13932 22916-22917 CD denotes °
T13933 22917-22918 NNP denotes C
T13934 22919-22922 CC denotes and
T13935 22923-22924 CD denotes 5
T13936 22924-22925 NN denotes %
T13937 22926-22929 CD denotes CO2
T13938 22930-22932 IN denotes in
T13939 22933-22936 NN denotes air
T13940 22936-22937 . denotes .
T13941 22938-22948 JJ denotes Peripheral
T13942 22949-22954 NN denotes blood
T13943 22955-22958 VBD denotes was
T13944 22959-22967 VBN denotes provided
T13945 22968-22970 IN denotes by
T13946 22971-22974 DT denotes the
T13947 22975-22980 NNP denotes Blood
T13948 22981-22985 NNP denotes Bank
T13949 22986-22988 IN denotes at
T13950 22989-22997 NNP denotes Buskerud
T13951 22998-23006 NNP denotes Regional
T13952 23007-23015 NNP denotes Hospital
T13953 23016-23020 IN denotes with
T13954 23021-23027 JJ denotes formal
T13955 23028-23037 NN denotes agreement
T13956 23038-23040 IN denotes by
T13957 23041-23044 DT denotes the
T13958 23045-23053 NNS denotes patients
T13959 23053-23054 , denotes ,
T14004 23294-23295 . denotes .
T14005 23296-23300 DT denotes This
T14006 23301-23310 NN denotes procedure
T14007 23311-23317 NNS denotes yields
T14008 23318-23322 JJR denotes less
T14009 23323-23327 IN denotes than
T14010 23328-23331 CD denotes 0.5
T14011 23331-23332 NN denotes %
T14012 23333-23334 NN denotes T
T14013 23335-23340 NNS denotes cells
T14014 23340-23341 , denotes ,
T14015 23342-23345 CD denotes 0.1
T14016 23345-23346 NN denotes %
T14017 23347-23349 NNP denotes NK
T14018 23350-23355 NNS denotes cells
T14019 23355-23356 , denotes ,
T14020 23357-23360 CC denotes and
T14021 23361-23364 CD denotes 0.5
T14022 23364-23365 NN denotes %
T14023 23366-23375 NNS denotes monocytes
T14024 23376-23378 IN denotes as
T14025 23379-23385 VBN denotes judged
T14026 23386-23388 IN denotes by
T14027 23389-23397 JJ denotes indirect
T14028 23398-23416 NN denotes immunofluorescence
T14029 23417-23425 NN denotes staining
T14030 23425-23426 . denotes .
T14031 23427-23430 DT denotes The
T14032 23431-23440 VBG denotes following
T14033 23441-23445 NN denotes cell
T14034 23446-23451 NNS denotes lines
T14035 23452-23456 IN denotes from
T14036 23457-23462 JJ denotes human
T14037 23463-23471 JJ denotes lymphoid
T14038 23472-23484 NNS denotes malignancies
T14039 23485-23489 VBD denotes were
T14040 23490-23500 VBN denotes maintained
T14041 23501-23503 IN denotes in
T14042 23504-23508 NNP denotes RPMI
T14043 23509-23513 CD denotes 1640
T14044 23514-23515 -LRB- denotes (
T14045 23515-23518 NNP denotes PAA
T14046 23519-23531 NNPS denotes Laboratories
T14047 23532-23536 NNP denotes GmbH
T14048 23536-23537 , denotes ,
T14049 23538-23546 NNP denotes Pasching
T14050 23546-23547 , denotes ,
T14051 23548-23555 NNP denotes Austria
T14052 23555-23556 -RRB- denotes )
T14053 23557-23569 VBN denotes supplemented
T14054 23570-23574 IN denotes with
T14055 23575-23577 CD denotes 10
T14056 23577-23578 NN denotes %
T14057 23579-23585 JJ denotes foetal
T14058 23586-23592 JJ denotes bovine
T14059 23593-23598 NN denotes serum
T14060 23599-23600 -LRB- denotes (
T14061 23600-23603 NNP denotes FCS
T14062 23603-23604 -RRB- denotes )
T14063 23604-23605 , denotes ,
T14064 23606-23609 CD denotes 100
T14065 23610-23618 NN denotes units/ml
T14066 23619-23629 NN denotes penicillin
T14067 23630-23631 NNP denotes G
T14068 23631-23632 , denotes ,
T14069 23633-23636 CC denotes and
T14070 23637-23640 CD denotes 100
T14071 23641-23649 NN denotes units/ml
T14072 23650-23652 IN denotes of
T14073 23653-23665 NNP denotes streptomycin
T14074 23666-23674 NN denotes sulphate
T14075 23674-23675 , denotes ,
T14076 23676-23679 CC denotes but
T14077 23680-23693 JJ denotes serum-starved
T14078 23694-23697 IN denotes for
T14079 23698-23700 IN denotes at
T14080 23701-23706 JJS denotes least
T14081 23707-23711 CD denotes four
T14082 23712-23717 NNS denotes hours
T14083 23718-23721 CC denotes and
T14084 23722-23730 VBN denotes cultured
T14085 23731-23733 IN denotes in
T14086 23734-23740 NNP denotes X-VIVO
T14087 23741-23743 CD denotes 15
T14088 23743-23744 NN denotes ™
T14089 23745-23749 WRB denotes when
T14090 23750-23758 VBN denotes included
T14091 23759-23761 IN denotes in
T14092 23762-23773 NNS denotes experiments
T14093 23773-23774 : denotes :
T14094 23775-23787 JJ denotes EBV-negative
T14095 23788-23790 NNP denotes BL
T14096 23791-23795 NN denotes cell
T14097 23796-23801 NNS denotes lines
T14098 23802-23807 NNP denotes Ramos
T14099 23808-23809 -LRB- denotes (
T14100 23809-23814 NNP denotes ECACC
T14101 23815-23823 CD denotes 85030802
T14102 23823-23824 -RRB- denotes )
T14103 23824-23825 , denotes ,
T14104 23826-23830 NNP denotes HL60
T14105 23831-23832 -LRB- denotes (
T14106 23832-23840 NNP denotes JCRB0085
T14107 23840-23841 -RRB- denotes )
T14108 23841-23842 . denotes .
T14167 23844-23850 NN denotes Growth
T14168 23851-23870 NNS denotes factors/supplements
T14169 23871-23874 DT denotes The
T14170 23875-23884 JJ denotes following
T14171 23885-23893 NNS denotes reagents
T14172 23894-23898 VBD denotes were
T14173 23899-23903 VBN denotes used
T14174 23904-23906 IN denotes at
T14175 23907-23916 JJ denotes indicated
T14176 23917-23931 NNS denotes concentrations
T14177 23931-23932 : denotes :
T14178 23933-23944 JJ denotes recombinant
T14179 23945-23950 JJ denotes human
T14180 23951-23952 -LRB- denotes (
T14181 23952-23955 NN denotes rhu
T14182 23955-23956 -RRB- denotes )
T14183 23957-23962 NN denotes BMP-6
T14184 23963-23964 -LRB- denotes (
T14185 23964-23965 CD denotes 1
T14186 23966-23968 NN denotes μg
T14187 23968-23969 NN denotes /
T14188 23969-23971 NN denotes ml
T14189 23971-23972 , denotes ,
T14190 23973-23975 IN denotes if
T14191 23976-23979 RB denotes not
T14192 23980-23989 VBN denotes specified
T14193 23990-23999 RB denotes otherwise
T14194 23999-24000 -RRB- denotes )
T14195 24000-24001 , denotes ,
T14196 24002-24005 FW denotes rhu
T14197 24006-24017 NNP denotes BMP-RIB/ALK
T14198 24017-24019 CD denotes -6
T14199 24019-24020 CD denotes /
T14200 24020-24022 NNP denotes Fc
T14201 24023-24030 NNP denotes Chimera
T14202 24031-24032 -LRB- denotes (
T14203 24032-24033 CD denotes 5
T14204 24034-24036 NN denotes μg
T14205 24036-24037 NN denotes /
T14206 24037-24039 NN denotes ml
T14207 24039-24040 -RRB- denotes )
T14208 24040-24041 , denotes ,
T14209 24042-24045 FW denotes rhu
T14210 24046-24056 NNP denotes BMPR-II/Fc
T14211 24057-24064 NNP denotes Chimera
T14212 24065-24066 -LRB- denotes (
T14213 24066-24067 CD denotes 5
T14214 24068-24070 NN denotes μg
T14215 24070-24071 NN denotes /
T14216 24071-24073 NN denotes ml
T14217 24073-24074 -RRB- denotes )
T14218 24074-24075 , denotes ,
T14219 24076-24079 CC denotes and
T14220 24080-24091 JJ denotes recombinant
T14221 24092-24097 NN denotes mouse
T14222 24098-24104 NNP denotes Noggin
T14223 24105-24106 -LRB- denotes (
T14224 24106-24107 CD denotes 5
T14225 24108-24110 NN denotes μg
T14226 24110-24111 NN denotes /
T14227 24111-24113 NN denotes ml
T14228 24113-24114 -RRB- denotes )
T14229 24115-24119 VBD denotes were
T14230 24120-24129 VBN denotes purchased
T14231 24130-24134 IN denotes from
T14232 24135-24138 NNP denotes R&D
T14233 24139-24146 NNP denotes Systems
T14234 24147-24148 -LRB- denotes (
T14235 24148-24156 NNP denotes Abingdon
T14236 24156-24157 , denotes ,
T14237 24158-24160 NNP denotes UK
T14238 24160-24161 -RRB- denotes )
T14239 24161-24162 : denotes ;
T14240 24163-24171 NNP denotes Anti-IgM
T14241 24172-24173 NN denotes F
T14242 24173-24174 -LRB- denotes (
T14243 24174-24176 NN denotes ab
T14244 24176-24177 -RRB- denotes )
T14245 24177-24178 CD denotes 2
T14246 24179-24188 NNS denotes fragments
T14247 24189-24191 IN denotes of
T14248 24192-24198 NN denotes rabbit
T14249 24199-24209 NN denotes polyclonal
T14250 24210-24220 NNS denotes antibodies
T14251 24221-24223 TO denotes to
T14252 24224-24229 JJ denotes human
T14253 24230-24233 NNP denotes IgM
T14254 24234-24239 NN denotes heavy
T14255 24240-24245 NN denotes chain
T14256 24246-24247 -LRB- denotes (
T14257 24247-24251 CD denotes 37.5
T14258 24252-24254 NN denotes μg
T14259 24254-24255 NN denotes /
T14260 24255-24257 NN denotes ml
T14261 24257-24258 -RRB- denotes )
T14262 24259-24262 VBD denotes was
T14263 24263-24271 VBN denotes obtained
T14264 24272-24276 IN denotes from
T14265 24277-24281 NNP denotes Dako
T14266 24281-24282 , denotes ,
T14267 24283-24293 NNP denotes Copenhagen
T14268 24293-24294 , denotes ,
T14269 24295-24302 NNP denotes Denmark
T14270 24303-24306 CC denotes and
T14271 24307-24310 NNP denotes rhu
T14272 24311-24315 NNP denotes CD40
T14273 24316-24322 NN denotes ligand
T14274 24323-24324 -LRB- denotes (
T14275 24324-24329 NNP denotes CD40L
T14276 24329-24330 , denotes ,
T14277 24331-24333 CD denotes 10
T14278 24334-24339 NN denotes ng/ml
T14279 24339-24340 -RRB- denotes )
T14280 24341-24344 VBD denotes was
T14281 24345-24346 DT denotes a
T14282 24347-24351 NN denotes gift
T14283 24352-24356 IN denotes from
T14284 24357-24364 NNP denotes Immunex
T14285 24365-24370 NNP denotes Corp.
T14286 24371-24372 -LRB- denotes (
T14287 24372-24379 NNP denotes Seattle
T14288 24379-24380 , denotes ,
T14289 24381-24383 NNP denotes WA
T14290 24383-24384 -RRB- denotes )
T14291 24384-24385 . denotes .
T14718 24387-24397 NNS denotes Antibodies
T14719 24398-24402 VBD denotes used
T14720 24403-24406 IN denotes for
T14721 24407-24411 NN denotes flow
T14722 24412-24422 JJ denotes cytometric
T14723 24423-24431 NN denotes analysis
T14724 24432-24435 CC denotes and
T14725 24436-24446 NN denotes immunoblot
T14726 24447-24455 NN denotes analysis
T14727 24456-24466 NNS denotes Antibodies
T14728 24467-24474 IN denotes against
T14729 24475-24478 DT denotes the
T14730 24479-24484 JJ denotes human
T14731 24485-24498 NNS denotes BMP-receptors
T14732 24499-24506 NNP denotes Act-RIA
T14733 24506-24507 , denotes ,
T14734 24508-24515 NNP denotes BMP-RIB
T14735 24515-24516 , denotes ,
T14736 24517-24524 NNP denotes BMPR-II
T14737 24524-24525 , denotes ,
T14738 24526-24534 NNP denotes Act-RIIA
T14739 24535-24538 CC denotes and
T14740 24539-24547 NNP denotes Act-RIIb
T14741 24548-24552 VBD denotes were
T14742 24553-24562 VBN denotes purchased
T14743 24563-24567 IN denotes from
T14744 24568-24569 NN denotes R
T14745 24570-24571 CC denotes &
T14746 24572-24573 NNP denotes D
T14747 24574-24581 NNP denotes Systems
T14748 24582-24583 -LRB- denotes (
T14749 24583-24591 NNP denotes Abingdon
T14750 24591-24592 , denotes ,
T14751 24593-24595 NNP denotes UK
T14752 24595-24596 -RRB- denotes )
T14753 24596-24597 . denotes .
T14754 24598-24607 NNP denotes Detection
T14755 24608-24610 IN denotes of
T14756 24611-24614 DT denotes the
T14757 24615-24628 NN denotes BMP-6-protein
T14758 24629-24632 VBZ denotes has
T14759 24633-24637 VBN denotes been
T14760 24638-24643 VBN denotes tried
T14761 24644-24648 IN denotes with
T14762 24649-24652 DT denotes the
T14763 24653-24662 VBG denotes following
T14764 24663-24673 NNS denotes antibodies
T14765 24673-24674 : denotes :
T14766 24675-24679 VB denotes goat
T14767 24680-24690 JJ denotes polyclonal
T14768 24691-24701 NN denotes anti-BMP-6
T14769 24702-24703 -LRB- denotes (
T14770 24703-24708 NNP denotes Santa
T14771 24709-24713 NNP denotes Cruz
T14772 24713-24714 , denotes ,
T14773 24715-24718 NNP denotes San
T14774 24719-24724 NNP denotes Diego
T14775 24724-24725 , denotes ,
T14776 24726-24728 NNP denotes CA
T14777 24728-24729 , denotes ,
T14778 24730-24733 NNP denotes USA
T14779 24733-24734 -RRB- denotes )
T14780 24734-24735 , denotes ,
T14781 24736-24746 JJ denotes monoclonal
T14782 24747-24752 NN denotes mouse
T14783 24753-24763 NN denotes anti-BMP-6
T14784 24764-24767 CC denotes and
T14785 24768-24778 JJ denotes polyclonal
T14786 24779-24783 NN denotes goat
T14787 24784-24794 NN denotes anti-BMP-6
T14788 24795-24799 IN denotes from
T14789 24800-24801 NNP denotes R
T14790 24802-24803 CC denotes &
T14791 24804-24805 NNP denotes D
T14792 24806-24813 NNP denotes Systems
T14793 24814-24815 -LRB- denotes (
T14794 24815-24823 NNP denotes Abingdon
T14795 24823-24824 , denotes ,
T14796 24825-24827 NNP denotes UK
T14797 24827-24828 -RRB- denotes )
T14798 24828-24829 , denotes ,
T14799 24830-24833 CC denotes and
T14800 24834-24839 NN denotes mouse
T14801 24840-24850 JJ denotes monoclonal
T14802 24851-24861 NN denotes anti-BMP-6
T14803 24862-24863 -LRB- denotes (
T14804 24863-24871 NNP denotes Chemicon
T14805 24872-24885 NNP denotes International
T14806 24886-24889 NNP denotes Inc
T14807 24889-24890 , denotes ,
T14808 24891-24899 NNP denotes Temecula
T14809 24899-24900 , denotes ,
T14810 24901-24903 NNP denotes CA
T14811 24903-24904 , denotes ,
T14812 24905-24908 NNP denotes USA
T14813 24908-24909 -RRB- denotes )
T14814 24909-24910 . denotes .
T14815 24911-24927 NNP denotes Characterisation
T14816 24928-24930 IN denotes of
T14817 24931-24945 JJ denotes BMP-signalling
T14818 24946-24954 NNS denotes pathways
T14819 24955-24958 VBD denotes was
T14820 24959-24963 VBN denotes done
T14821 24964-24966 IN denotes by
T14822 24967-24970 NN denotes use
T14823 24971-24973 IN denotes of
T14824 24974-24992 JJ denotes anti-phospho-Smad1
T14825 24992-24993 , denotes ,
T14826 24994-24996 CD denotes -5
T14827 24996-24997 , denotes ,
T14828 24998-24999 : denotes -
T14829 24999-25002 CC denotes and
T14830 25003-25004 CD denotes 8
T14831 25005-25015 JJ denotes polyclonal
T14832 25016-25024 NN denotes antibody
T14833 25025-25026 -LRB- denotes (
T14834 25026-25034 NNP denotes Chemicon
T14835 25034-25035 , denotes ,
T14836 25036-25044 NNP denotes Temecula
T14837 25044-25045 , denotes ,
T14838 25046-25048 NNP denotes CA
T14839 25048-25049 , denotes ,
T14840 25050-25053 NNP denotes USA
T14841 25053-25054 -RRB- denotes )
T14842 25054-25055 . denotes .
T14843 25056-25066 NN denotes Expression
T14844 25067-25073 NNS denotes levels
T14845 25074-25076 IN denotes of
T14846 25077-25080 NNP denotes Id1
T14847 25081-25082 CD denotes 3
T14848 25083-25091 NNS denotes proteins
T14849 25092-25096 VBD denotes were
T14850 25097-25105 VBN denotes detected
T14851 25106-25110 IN denotes with
T14852 25111-25121 JJ denotes polyclonal
T14853 25122-25128 NN denotes rabbit
T14854 25129-25137 NN denotes antibody
T14855 25138-25141 CC denotes and
T14856 25142-25151 NN denotes detection
T14857 25152-25155 VBD denotes was
T14858 25156-25163 VBN denotes blocked
T14859 25164-25168 IN denotes with
T14860 25169-25177 VBG denotes blocking
T14896 25372-25374 NNP denotes AS
T14897 25375-25376 -LRB- denotes (
T14898 25376-25386 NNP denotes Copenhagen
T14899 25386-25387 , denotes ,
T14900 25388-25395 NNP denotes Denmark
T14901 25395-25396 -RRB- denotes )
T14902 25397-25400 IN denotes for
T14903 25401-25411 NN denotes immunoblot
T14904 25412-25420 NN denotes analysis
T14905 25420-25421 . denotes .
T14906 25422-25434 NN denotes Anti-β-actin
T14907 25435-25438 VBD denotes was
T14908 25439-25443 IN denotes from
T14909 25444-25454 NNP denotes Santa-Cruz
T14910 25454-25455 . denotes .
T14911 25456-25460 IN denotes From
T14912 25461-25467 NNP denotes Becton
T14913 25468-25477 NNP denotes Dickinson
T14914 25478-25479 -LRB- denotes (
T14915 25479-25482 NNP denotes San
T14916 25483-25487 NNP denotes Jose
T14917 25487-25488 , denotes ,
T14918 25489-25491 NNP denotes CA
T14919 25491-25492 -RRB- denotes )
T14920 25492-25493 , denotes ,
T14921 25494-25496 PRP denotes we
T14922 25497-25506 VBD denotes purchased
T14923 25507-25519 JJ denotes anti-CD19-PE
T14959 25711-25714 NNP denotes USA
T14960 25714-25715 -RRB- denotes )
T14961 25715-25716 . denotes .
T15151 25718-25722 NNP denotes Cell
T15152 25723-25730 VBG denotes sorting
T15153 25731-25737 NNP denotes Highly
T15154 25738-25746 VBD denotes purified
T15155 25747-25751 NNP denotes CD19
T15156 25751-25752 NNP denotes +
T15157 25752-25756 NNP denotes CD27
T15158 25756-25757 : denotes -
T15159 25758-25760 CC denotes or
T15160 25761-25765 CD denotes CD19
T15161 25765-25766 CD denotes +
T15162 25766-25770 NNP denotes CD27
T15163 25770-25771 NN denotes +
T15164 25772-25777 NNS denotes cells
T15165 25778-25782 VBD denotes were
T15166 25783-25791 VBN denotes obtained
T15167 25792-25794 IN denotes by
T15168 25795-25803 VBG denotes staining
T15169 25804-25808 NNP denotes CD19
T15170 25808-25809 CD denotes +
T15171 25810-25815 NNS denotes cells
T15172 25816-25820 IN denotes with
T15173 25821-25830 JJ denotes anti-CD27
T15174 25831-25833 NNP denotes PE
T15175 25834-25837 CC denotes and
T15176 25838-25842 NNP denotes CD19
T15177 25843-25846 NNP denotes PC5
T15178 25847-25851 NNP denotes mAbs
T15179 25852-25855 IN denotes for
T15180 25856-25858 CD denotes 30
T15181 25859-25866 NNS denotes minutes
T15182 25867-25869 IN denotes at
T15183 25870-25871 CD denotes 4
T15184 25871-25872 CD denotes °
T15185 25872-25873 NNP denotes C
T15186 25873-25874 , denotes ,
T15187 25875-25883 VBN denotes followed
T15188 25884-25886 IN denotes by
T15189 25887-25894 VBG denotes washing
T15190 25895-25899 IN denotes with
T15191 25900-25903 NNP denotes PBS
T15192 25904-25907 CC denotes and
T15193 25908-25915 VBG denotes sorting
T15194 25916-25918 IN denotes on
T15195 25919-25923 NNP denotes FACS
T15196 25924-25928 NNP denotes DiVa
T15197 25929-25933 IN denotes from
T15198 25934-25940 NNP denotes Becton
T15199 25941-25950 NNP denotes Dickinson
T15200 25950-25951 . denotes .
T15878 27095-27103 NN denotes Analysis
T15879 27104-27106 IN denotes of
T15880 27107-27112 NNP denotes BMP-6
T15881 27113-27122 NN denotes messenger
T15882 27123-27126 NNP denotes RNA
T15883 27127-27128 -LRB- denotes (
T15884 27128-27132 NNP denotes mRNA
T15885 27132-27133 -RRB- denotes )
T15886 27134-27144 NN denotes expression
T15887 27145-27155 JJ denotes Endogenous
T15888 27156-27166 NN denotes expression
T15889 27167-27169 IN denotes of
T15890 27170-27173 DT denotes the
T15891 27174-27179 NNP denotes BMP-6
T15892 27180-27184 NN denotes gene
T15893 27185-27188 VBD denotes was
T15894 27189-27197 VBN denotes examined
T15895 27198-27200 IN denotes by
T15896 27201-27208 JJ denotes reverse
T15897 27209-27233 NN denotes transcription-polymerase
T15898 27234-27239 NN denotes chain
T15899 27240-27248 NN denotes reaction
T15900 27248-27249 . denotes .
T15901 27250-27255 JJ denotes Total
T15902 27256-27259 NNP denotes RNA
T15903 27260-27263 VBD denotes was
T15904 27264-27272 VBN denotes isolated
T15905 27273-27278 VBG denotes using
T15906 27279-27289 RB denotes Absolutely
T15907 27290-27293 NNP denotes RNA
T15908 27293-27294 CD denotes ™
T15909 27295-27301 NNP denotes RT-PCR
T15910 27302-27310 NNP denotes Miniprep
T15911 27311-27314 NNP denotes Kit
T15912 27315-27316 -LRB- denotes (
T15913 27316-27326 NNP denotes Stratagene
T15914 27327-27333 NNP denotes Europe
T15915 27333-27334 , denotes ,
T15916 27335-27344 NNP denotes Amsterdam
T15917 27344-27345 , denotes ,
T15918 27346-27356 NNP denotes Netherland
T15919 27356-27357 -RRB- denotes )
T15920 27358-27367 VBG denotes according
T15921 27368-27370 TO denotes to
T15922 27371-27374 DT denotes the
T15923 27375-27388 NNS denotes manufacturers
T15924 27389-27401 NNS denotes instructions
T15925 27401-27402 . denotes .
T15926 27403-27417 NN denotes Quantification
T15927 27418-27420 IN denotes of
T15928 27421-27424 DT denotes the
T15929 27425-27433 JJ denotes isolated
T15930 27434-27439 JJ denotes total
T15931 27440-27443 NNP denotes RNA
T15932 27444-27447 VBD denotes was
T15933 27448-27456 VBN denotes achieved
T15934 27457-27459 IN denotes by
T15935 27460-27465 VBG denotes using
T15936 27466-27484 JJ denotes spectrophotometric
T15937 27485-27490 NNP denotes OD260
T15938 27491-27503 NNS denotes measurements
T15939 27503-27504 . denotes .
T15940 27505-27510 NNP denotes Equal
T15941 27511-27518 NNS denotes amounts
T15942 27519-27521 IN denotes of
T15943 27522-27525 NNP denotes RNA
T15944 27526-27530 VBD denotes were
T15945 27531-27535 RB denotes then
T15946 27536-27543 VB denotes reverse
T15947 27544-27555 VBN denotes transcribed
T15948 27556-27558 TO denotes to
T15949 27559-27563 VB denotes cDNA
T15950 27564-27568 IN denotes with
T15951 27569-27575 NNP denotes TaqMan
T15952 27575-27576 NNP denotes ®
T15953 27577-27584 VB denotes Reverse
T15954 27585-27598 NNP denotes Transcription
T15955 27599-27607 NNP denotes Reagents
T15956 27608-27609 -LRB- denotes (
T15957 27609-27616 NNP denotes Applied
T15958 27617-27627 NNPS denotes Biosystems
T15959 27627-27628 , denotes ,
T15960 27629-27635 NNP denotes Foster
T15961 27636-27640 NNP denotes City
T15962 27640-27641 , denotes ,
T15963 27642-27644 NNP denotes CA
T15964 27644-27645 , denotes ,
T15965 27646-27651 NNP denotes U.S.A
T15966 27651-27652 -RRB- denotes )
T15967 27652-27653 . denotes .
T15968 27654-27656 TO denotes To
T15969 27657-27664 VB denotes measure
T15970 27665-27669 NNP denotes mRNA
T15971 27670-27680 NN denotes expression
T15972 27681-27683 IN denotes of
T15973 27684-27688 NNP denotes BMP6
T15974 27688-27689 , denotes ,
T15975 27690-27693 NNP denotes Id1
T15976 27694-27697 NNP denotes Id4
T15977 27698-27701 CC denotes and
T15978 27702-27706 NNP denotes PGK1
T15979 27707-27710 NNP denotes PCR
T15980 27711-27715 VBD denotes were
T15981 27716-27723 VBN denotes carried
T15982 27724-27727 RP denotes out
T15983 27728-27732 IN denotes with
T15984 27733-27739 NNP denotes TaqMan
T15985 27739-27740 VBD denotes ®
T15986 27741-27750 JJ denotes universal
T15987 27751-27757 NN denotes master
T15988 27758-27761 NN denotes mix
T15989 27761-27762 . denotes .
T15990 27763-27770 NNS denotes Primers
T15991 27771-27774 CC denotes and
T15992 27775-27781 NNS denotes probes
T15993 27782-27786 VBD denotes were
T15994 27787-27795 VBN denotes provided
T15995 27796-27798 IN denotes by
T15996 27799-27814 NNP denotes Assay-on-Demand
T15997 27815-27816 -LRB- denotes (
T15998 27816-27823 NNP denotes Applied
T15999 27824-27834 NNPS denotes Biosystems
T16000 27834-27835 -RRB- denotes )
T16001 27835-27836 . denotes .
T16002 27837-27840 NNP denotes PCR
T16003 27841-27850 NNS denotes reactions
T16004 27851-27855 VBD denotes were
T16005 27856-27863 VBN denotes carried
T16006 27864-27867 RP denotes out
T16007 27868-27870 IN denotes in
T16008 27871-27872 DT denotes a
T16009 27873-27878 JJ denotes final
T16010 27879-27885 NN denotes volume
T16011 27886-27888 IN denotes of
T16012 27889-27891 CD denotes 25
T16013 27892-27894 NN denotes μl
T16014 27895-27896 -LRB- denotes (
T16015 27896-27901 NNP denotes BMP-6
T16016 27901-27902 -RRB- denotes )
T16017 27903-27905 CC denotes or
T16018 27906-27908 CD denotes 20
T16019 27909-27911 NN denotes μl
T16020 27912-27913 -LRB- denotes (
T16021 27913-27916 CD denotes ID1
T16022 27916-27917 -RRB- denotes )
T16023 27917-27918 . denotes .
T16024 27919-27922 DT denotes The
T16025 27923-27927 NNP denotes cDNA
T16026 27928-27933 VBD denotes added
T16027 27934-27936 TO denotes to
T16028 27937-27941 DT denotes each
T16029 27942-27950 NN denotes reaction
T16030 27951-27954 VBD denotes was
T16031 27955-27965 JJ denotes equivalent
T16032 27966-27968 TO denotes to
T16033 27969-27972 DT denotes the
T16034 27973-27978 NN denotes input
T16035 27979-27981 IN denotes of
T16036 27982-27984 CD denotes 20
T16037 27985-27987 NN denotes ng
T16038 27988-27990 IN denotes of
T16039 27991-27996 JJ denotes total
T16040 27997-28000 NNP denotes RNA
T16041 28000-28001 . denotes .
T16042 28002-28005 DT denotes The
T16043 28006-28010 NN denotes gene
T16044 28011-28021 NN denotes expression
T16045 28022-28025 VBD denotes was
T16046 28026-28036 VBN denotes quantified
T16047 28037-28042 VBG denotes using
T16048 28043-28046 DT denotes the
T16049 28047-28055 JJ denotes standard
T16050 28056-28061 NN denotes curve
T16051 28062-28068 NN denotes method
T16052 28069-28070 -LRB- denotes (
T16053 28070-28074 NNP denotes BMP6
T16054 28074-28075 -RRB- denotes )
T16055 28075-28076 , denotes ,
T16056 28077-28079 CC denotes or
T16057 28080-28083 DT denotes the
T16058 28084-28095 JJ denotes comparative
T16059 28096-28098 NNP denotes CT
T16060 28099-28105 NN denotes method
T16061 28106-28107 -LRB- denotes (
T16062 28107-28110 NNP denotes Id1
T16063 28110-28111 -RRB- denotes )
T16064 28112-28114 IN denotes as
T16065 28115-28124 VBN denotes described
T16066 28125-28127 IN denotes in
T16067 28128-28135 NNP denotes ABI7700
T16068 28136-28140 NNP denotes User
T16069 28141-28149 NNP denotes Bulletin
T16070 28150-28151 CD denotes 2
T16071 28152-28153 -LRB- denotes (
T16072 28153-28160 NNP denotes Applied
T16073 28161-28171 NNPS denotes Biosystems
T16074 28171-28172 -RRB- denotes )
T16075 28172-28173 . denotes .
T16076 28174-28177 DT denotes The
T16077 28178-28188 NN denotes expression
T16078 28189-28192 VBD denotes was
T16079 28193-28197 RB denotes then
T16080 28198-28208 VBN denotes normalized
T16081 28209-28211 TO denotes to
T16082 28212-28215 DT denotes the
T16083 28216-28226 NN denotes expression
T16084 28227-28232 NN denotes level
T16085 28233-28235 IN denotes of
T16086 28236-28240 NNP denotes PGK1
T16087 28240-28241 . denotes .
T16088 28242-28246 CD denotes PGK1
T16089 28247-28250 VBD denotes was
T16090 28251-28257 VBN denotes chosen
T16091 28257-28258 , denotes ,
T16092 28259-28266 IN denotes because
T16093 28267-28269 PRP denotes it
T16094 28270-28273 VBZ denotes has
T16095 28274-28278 VBN denotes been
T16096 28279-28284 VBN denotes shown
T16097 28285-28287 TO denotes to
T16098 28288-28292 VB denotes have
T16099 28293-28296 JJ denotes low
T16100 28297-28307 NN denotes expression
T16101 28308-28319 NN denotes variability
T16102 28320-28325 IN denotes among
T16103 28326-28336 JJ denotes lymphocyte
T16104 28337-28346 NNS denotes specimens
T16105 28347-28348 NNP denotes [
T16106 28348-28350 CD denotes 56
T16107 28350-28351 NNP denotes ]
T16108 28351-28352 . denotes .
T16109 28353-28363 NN denotes Expression
T16110 28364-28370 NNS denotes levels
T16111 28371-28373 IN denotes in
T16112 28374-28375 NNP denotes B
T16113 28376-28381 NNS denotes cells
T16114 28382-28386 VBD denotes were
T16115 28387-28391 RB denotes then
T16116 28392-28399 VBN denotes related
T16117 28400-28402 TO denotes to
T16118 28403-28406 DT denotes the
T16119 28407-28417 NN denotes expression
T16120 28418-28424 NNS denotes levels
T16121 28425-28427 IN denotes in
T16122 28428-28433 NNP denotes Ramos
T16123 28434-28439 NNS denotes cells
T16124 28439-28440 . denotes .
T16348 28442-28446 NNP denotes Cell
T16349 28447-28460 NN denotes proliferation
T16350 28461-28464 IN denotes For
T16351 28465-28475 NN denotes estimation
T16352 28476-28478 IN denotes of
T16353 28479-28482 NNP denotes DNA
T16354 28483-28492 NN denotes synthesis
T16355 28492-28493 , denotes ,
T16356 28494-28498 NNP denotes CD19
T16357 28498-28499 NNP denotes +
T16358 28500-28505 NNS denotes cells
T16359 28506-28507 -LRB- denotes (
T16360 28507-28510 CD denotes 7.5
T16361 28511-28512 NN denotes ×
T16362 28513-28516 CD denotes 104
T16363 28517-28524 CD denotes cells/0
T16364 28524-28526 CD denotes .2
T16365 28527-28529 NN denotes ml
T16366 28529-28530 -RRB- denotes )
T16367 28531-28533 CC denotes or
T16368 28534-28539 NNP denotes Ramos
T16369 28540-28545 NNS denotes cells
T16370 28546-28547 -LRB- denotes (
T16371 28547-28548 CD denotes 1
T16372 28549-28550 CD denotes ×
T16373 28551-28554 CD denotes 104
T16374 28555-28562 CD denotes cells/0
T16375 28562-28564 CD denotes .2
T16376 28565-28567 NN denotes ml
T16377 28567-28568 -RRB- denotes )
T16378 28569-28573 VBD denotes were
T16379 28574-28582 VBN denotes cultured
T16380 28583-28585 IN denotes in
T16381 28586-28596 NN denotes triplicate
T16382 28597-28599 IN denotes in
T16383 28600-28610 NN denotes microtiter
T16384 28611-28616 NNS denotes wells
T16385 28616-28617 . denotes .
T16386 28618-28621 DT denotes The
T16387 28622-28627 NNS denotes cells
T16388 28628-28632 VBD denotes were
T16389 28633-28639 VBN denotes pulsed
T16390 28640-28644 IN denotes with
T16391 28645-28648 CD denotes 3.7
T16392 28649-28650 CD denotes ×
T16393 28651-28656 NNP denotes 104Bq
T16394 28657-28658 NNP denotes [
T16395 28658-28660 NNP denotes 3H
T16396 28660-28661 NNP denotes ]
T16397 28661-28670 NN denotes thymidine
T16398 28671-28672 -LRB- denotes (
T16399 28672-28680 NNP denotes Amersham
T16400 28680-28681 , denotes ,
T16401 28682-28697 NNP denotes Buckinghamshire
T16402 28697-28698 , denotes ,
T16403 28699-28701 NNP denotes UK
T16404 28701-28702 -RRB- denotes )
T16405 28703-28706 IN denotes for
T16406 28707-28710 DT denotes the
T16407 28711-28715 JJ denotes last
T16408 28716-28718 CD denotes 16
T16409 28719-28720 NN denotes h
T16410 28721-28723 IN denotes of
T16411 28724-28725 DT denotes a
T16412 28726-28730 JJ denotes 72-h
T16413 28731-28741 NN denotes incubation
T16414 28741-28742 . denotes .
T16415 28743-28746 DT denotes The
T16416 28747-28752 NNS denotes cells
T16417 28753-28757 VBD denotes were
T16418 28758-28767 VBN denotes harvested
T16419 28768-28773 VBG denotes using
T16420 28774-28776 DT denotes an
T16421 28777-28786 VBN denotes automated
T16422 28787-28791 NN denotes cell
T16423 28792-28801 NN denotes harvester
T16424 28802-28803 -LRB- denotes (
T16425 28803-28810 NNP denotes Packard
T16426 28811-28821 NNP denotes Instrument
T16427 28822-28829 NNP denotes Company
T16428 28829-28830 , denotes ,
T16429 28831-28838 NNP denotes Meriden
T16430 28838-28839 , denotes ,
T16431 28840-28842 NNP denotes CT
T16432 28842-28843 , denotes ,
T16433 28844-28847 NNP denotes USA
T16434 28847-28848 -RRB- denotes )
T16435 28849-28852 CC denotes and
T16436 28853-28854 NNP denotes [
T16437 28854-28856 NNP denotes 3H
T16438 28856-28857 NNP denotes ]
T16439 28857-28866 NN denotes thymidine
T16440 28867-28880 NN denotes incorporation
T16441 28881-28884 VBD denotes was
T16442 28885-28895 VBN denotes determined
T16443 28896-28898 IN denotes in
T16444 28899-28900 DT denotes a
T16445 28901-28914 NN denotes scintillation
T16446 28915-28922 NN denotes counter
T16447 28923-28924 -LRB- denotes (
T16448 28924-28932 NNP denotes TopCount
T16449 28932-28933 , denotes ,
T16450 28934-28941 NNP denotes Packard
T16451 28942-28952 NNP denotes Instrument
T16452 28953-28960 NNP denotes Company
T16453 28961-28965 NNP denotes Inc.
T16454 28965-28966 , denotes ,
T16455 28967-28974 NNP denotes Meriden
T16456 28974-28975 , denotes ,
T16457 28976-28978 NNP denotes CT
T16458 28978-28979 -RRB- denotes )
T16459 28979-28980 . denotes .
T16540 28982-28995 NN denotes Determination
T16541 28996-28998 IN denotes of
T16542 28999-29003 NN denotes cell
T16543 29004-29009 NN denotes death
T16544 29010-29014 NNP denotes Cell
T16545 29015-29020 NN denotes death
T16546 29021-29024 VBD denotes was
T16547 29025-29033 VBN denotes measured
T16548 29034-29036 IN denotes by
T16549 29037-29042 JJ denotes vital
T16550 29043-29046 NN denotes dye
T16551 29047-29056 NN denotes exclusion
T16552 29057-29061 NN denotes test
T16553 29062-29064 IN denotes by
T16554 29065-29073 VBG denotes staining
T16555 29074-29079 NNS denotes cells
T16556 29080-29084 IN denotes with
T16557 29085-29086 CD denotes 5
T16558 29087-29089 NN denotes μg
T16559 29089-29090 NN denotes /
T16560 29090-29092 NN denotes ml
T16561 29093-29102 NN denotes propidium
T16562 29103-29109 NN denotes iodide
T16563 29110-29111 -LRB- denotes (
T16564 29111-29112 NNP denotes [
T16565 29112-29114 NNP denotes PI
T16566 29114-29115 NNP denotes ]
T16567 29115-29116 : denotes ;
T16568 29117-29127 NNP denotes Calbiochem
T16569 29128-29133 NNP denotes Corp.
T16570 29133-29134 : denotes ;
T16571 29135-29137 NNP denotes La
T16572 29138-29143 NNP denotes Jolla
T16573 29143-29144 , denotes ,
T16574 29145-29147 NNP denotes CA
T16575 29147-29148 : denotes ;
T16576 29149-29150 CD denotes 5
T16577 29151-29156 NN denotes mg/ml
T16578 29156-29157 -RRB- denotes )
T16579 29158-29161 IN denotes for
T16580 29162-29165 CD denotes one
T16581 29166-29172 NN denotes minute
T16582 29173-29175 IN denotes on
T16583 29176-29179 NN denotes ice
T16584 29179-29180 . denotes .
T16585 29181-29183 IN denotes At
T16586 29184-29189 JJS denotes least
T16587 29190-29195 CD denotes 1,000
T16588 29196-29201 NNS denotes cells
T16589 29202-29205 IN denotes per
T16590 29206-29212 NN denotes sample
T16591 29213-29217 VBD denotes were
T16592 29218-29221 VBN denotes run
T16593 29222-29224 IN denotes on
T16594 29225-29226 DT denotes a
T16595 29227-29229 NNP denotes BD
T16596 29230-29241 NNP denotes FACSCalibur
T16597 29242-29246 NN denotes flow
T16598 29247-29256 NN denotes cytometer
T16599 29256-29257 . denotes .
T16653 29259-29270 NNP denotes Statistical
T16654 29271-29279 NN denotes analysis
T16655 29280-29283 DT denotes The
T16656 29284-29295 JJ denotes statistical
T16657 29296-29308 NN denotes significance
T16658 29309-29311 IN denotes of
T16659 29312-29323 NNS denotes differences
T16660 29324-29331 IN denotes between
T16661 29332-29338 NNS denotes groups
T16662 29339-29342 VBD denotes was
T16663 29343-29353 VBN denotes determined
T16664 29354-29359 VBG denotes using
T16665 29360-29363 DT denotes the
T3273 5037-5040 DT denotes the
T11547 18337-18341 NN denotes role
T11535 18287-18289 CD denotes 35
T11536 18289-18290 NNP denotes ]
T11537 18290-18291 . denotes .
T11538 18292-18300 RB denotes Moreover
T11539 18300-18301 , denotes ,
T11540 18302-18307 NNP denotes BMP-6
T11541 18308-18311 VBZ denotes has
T11542 18312-18316 VBN denotes been
T11543 18317-18326 VBN denotes suggested
T11544 18327-18329 TO denotes to
T11545 18330-18334 VB denotes play
T11546 18335-18336 DT denotes a
T11548 18342-18344 IN denotes in
T11549 18345-18355 JJ denotes rheumatoid
T11550 18356-18365 NNS denotes arthritis
T11551 18366-18367 -LRB- denotes (
T11552 18367-18369 NNP denotes RA
T11553 18369-18370 -RRB- denotes )
T11554 18371-18372 NNP denotes [
T11711 19223-19224 , denotes ,
T11712 19225-19227 DT denotes an
T11713 19228-19237 NN denotes autocrine
T11714 19238-19243 NN denotes BMP-6
T11715 19244-19248 NN denotes loop
T11716 19249-19252 VBZ denotes has
T11717 19253-19257 VBN denotes been
T11718 19258-19266 VBN denotes reported
T11719 19267-19269 IN denotes by
T11720 19270-19276 NNS denotes others
T11721 19277-19279 IN denotes in
T11722 19280-19292 NNS denotes chondrocytes
T11723 19293-19296 CC denotes and
T11724 19297-19299 IN denotes in
T11725 19300-19303 DT denotes the
T11726 19304-19311 NN denotes ovarium
T11727 19312-19313 NNP denotes [
T11728 19313-19321 CD denotes 46,19,18
T11729 19321-19322 NNP denotes ]
T11730 19322-19323 . denotes .
T11731 19324-19333 RB denotes Therefore
T11732 19333-19334 , denotes ,
T11733 19335-19337 PRP denotes we
T11734 19338-19344 VBD denotes wanted
T11735 19345-19347 TO denotes to
T11736 19348-19355 VB denotes explore
T11737 19356-19359 DT denotes the
T11738 19360-19371 NN denotes possibility
T11739 19372-19375 IN denotes for
T11740 19376-19378 DT denotes an
T11741 19379-19388 NN denotes autocrine
T12102 21398-21400 CC denotes or
T12103 21401-21407 NN denotes tissue
T12104 21408-21412 IN denotes with
T12105 21413-21420 NN denotes contact
T12106 21421-21423 TO denotes to
T12107 21424-21427 DT denotes the
T12108 21428-21441 JJ denotes hematopoietic
T12109 21442-21448 NN denotes system
T12110 21448-21449 . denotes .
T12111 21450-21453 CD denotes One
T12112 21454-21458 RB denotes well
T12113 21459-21469 VBN denotes recognized
T12114 21470-21476 NN denotes source
T12115 21477-21480 IN denotes for
T12116 21481-21486 NN denotes BMP-6
T12117 21487-21497 NN denotes production
T12118 21498-21500 VBZ denotes is
T13607 22600-22607 VBP denotes provide
T13608 22608-22609 DT denotes a
T13609 22610-22619 NN denotes rationale
T13610 22620-22622 TO denotes to
T13611 22623-22630 RBR denotes further
T13612 22631-22638 VB denotes examine
T13613 22639-22642 DT denotes the
T13614 22643-22647 NN denotes role
T13615 22648-22650 IN denotes of
T13616 22651-22656 NNP denotes BMP-6
T13617 22657-22667 VBG denotes signalling
T13618 22668-22670 IN denotes in
T13619 22671-22677 JJ denotes normal
T13620 22678-22679 NNP denotes B
T13621 22680-22684 NN denotes cell
T13960 23055-23058 CC denotes and
T13961 23059-23067 NN denotes approval
T13962 23068-23070 IN denotes by
T13963 23071-23074 DT denotes the
T13964 23075-23083 JJ denotes regional
T13965 23084-23090 NNS denotes ethics
T13966 23091-23100 NN denotes committee
T13967 23100-23101 . denotes .
T13968 23102-23108 NNP denotes Highly
T13969 23109-23117 VBD denotes purified
T13970 23118-23125 VBG denotes resting
T13971 23126-23131 JJ denotes human
T13972 23132-23145 NNS denotes B-lymphocytes
T13973 23146-23147 -LRB- denotes (
T13974 23147-23151 CD denotes CD19
T13975 23151-23152 NN denotes +
T13976 23153-23158 NNS denotes cells
T13977 23158-23159 -RRB- denotes )
T13978 23160-23164 VBD denotes were
T13979 23165-23173 VBN denotes isolated
T13980 23174-23178 IN denotes from
T13981 23179-23182 DT denotes the
T13982 23183-23193 JJ denotes peripheral
T13983 23194-23199 NN denotes blood
T13984 23200-23202 IN denotes by
T13985 23203-23212 VBG denotes rosetting
T13986 23213-23217 IN denotes with
T13987 23218-23232 JJ denotes immunomagnetic
T13988 23233-23238 NNS denotes beads
T13989 23239-23240 -LRB- denotes (
T13990 23240-23249 NNPS denotes Dynabeads
T13991 23250-23254 NNP denotes M450
T13992 23254-23255 : denotes ;
T13993 23256-23261 NNP denotes Dynal
T13994 23261-23262 , denotes ,
T13995 23263-23267 NNP denotes Oslo
T13996 23267-23268 , denotes ,
T13997 23269-23275 NNP denotes Norway
T13998 23275-23276 -RRB- denotes )
T13999 23277-23279 IN denotes as
T14000 23280-23289 VBN denotes described
T14001 23290-23291 NNP denotes [
T14002 23291-23293 CD denotes 55
T14003 23293-23294 NNP denotes ]
T14861 25178-25185 NN denotes peptide
T14862 25186-25190 IN denotes from
T14863 25191-25196 NNP denotes Santa
T14864 25197-25201 NNP denotes Cruz
T14865 25202-25215 NNP denotes Biotechnology
T14866 25216-25217 -LRB- denotes (
T14867 25217-25222 NNP denotes Santa
T14868 25223-25227 NNP denotes Cruz
T14869 25227-25228 , denotes ,
T14870 25229-25232 NNP denotes San
T14871 25233-25238 NNP denotes Diego
T14872 25238-25239 , denotes ,
T14873 25240-25242 NNP denotes CA
T14874 25242-25243 , denotes ,
T14875 25244-25247 NNP denotes USA
T14876 25247-25248 -RRB- denotes )
T14877 25248-25249 . denotes .
T14878 25250-25252 IN denotes As
T14879 25253-25262 JJ denotes secondary
T14880 25263-25273 NNS denotes antibodies
T14881 25274-25280 VBD denotes served
T14882 25281-25291 JJ denotes anti-mouse
T14883 25291-25292 , denotes ,
T14884 25293-25302 JJ denotes anti-goat
T14885 25303-25305 CC denotes or
T14886 25306-25317 JJ denotes anti-rabbit
T14887 25318-25321 SYM denotes IgG
T14888 25321-25322 : denotes -
T14889 25323-25334 NN denotes horseradish
T14890 25335-25345 NN denotes peroxidase
T14891 25346-25347 -LRB- denotes (
T14892 25347-25350 NNP denotes HRP
T14893 25350-25351 -RRB- denotes )
T14894 25352-25356 IN denotes from
T14895 25357-25371 NNP denotes Dakocytomation
T14924 25519-25520 , denotes ,
T14925 25521-25535 JJ denotes anti-CD19-FITC
T14926 25535-25536 . denotes .
T14927 25537-25540 DT denotes The
T14928 25541-25551 NNS denotes antibodies
T14929 25552-25556 VBN denotes used
T14930 25557-25560 IN denotes for
T14931 25561-25565 NN denotes cell
T14932 25566-25573 VBG denotes sorting
T14933 25574-25578 VBD denotes were
T14934 25579-25588 JJ denotes anti-CD19
T14935 25589-25592 NNS denotes PC5
T14936 25593-25597 IN denotes from
T14937 25598-25608 NNP denotes Immunotech
T14938 25609-25611 NNP denotes SA
T14939 25612-25613 -LRB- denotes (
T14940 25613-25622 NNP denotes Marseille
T14941 25622-25623 , denotes ,
T14942 25624-25630 NNP denotes France
T14943 25630-25631 -RRB- denotes )
T14944 25632-25635 CC denotes and
T14945 25636-25645 JJ denotes anti-CD27
T14946 25646-25648 NN denotes PE
T14947 25649-25653 IN denotes from
T14948 25654-25660 NNP denotes Becton
T14949 25661-25670 NNP denotes Dickinson
T14950 25670-25671 , denotes ,
T14951 25672-25683 NNP denotes Biosciences
T14952 25684-25694 NNP denotes Pharmingen
T14953 25695-25696 -LRB- denotes (
T14954 25696-25699 NNP denotes San
T14955 25700-25705 NNP denotes Diego
T14956 25705-25706 , denotes ,
T14957 25707-25709 NNP denotes CA
T14958 25709-25710 , denotes ,
T16666 29364-29370 VBN denotes paired
T16667 29371-29381 JJ denotes two-tailed
T16668 29382-29390 NNP denotes Wilcoxon
T16669 29391-29404 JJ denotes nonparametric
T16670 29405-29409 NN denotes test
T16671 29409-29410 , denotes ,
T16672 29411-29413 IN denotes by
T16673 29414-29422 VBG denotes applying
T16674 29423-29429 NNP denotes SPSS10
T16675 29429-29431 CD denotes .1
T16676 29432-29440 NN denotes software
T16677 29441-29442 -LRB- denotes (
T16678 29442-29446 NNP denotes SPSS
T16679 29447-29451 NNP denotes Inc.
T16680 29451-29452 , denotes ,
T16681 29453-29460 NNP denotes Chicago
T16682 29460-29461 , denotes ,
T16683 29462-29464 NNP denotes IL
T16684 29464-29465 , denotes ,
T16685 29466-29469 NNP denotes USA
T16686 29469-29470 -RRB- denotes )
T16687 29470-29471 . denotes .
T16688 29472-29473 NNP denotes P
T16689 29474-29480 VBZ denotes values
T16690 29481-29485 JJR denotes less
T16691 29486-29490 IN denotes than
T16692 29491-29495 CD denotes 0.05
T16693 29496-29500 VBD denotes were
T16694 29501-29511 VBN denotes considered
T16695 29512-29523 JJ denotes significant
T16696 29523-29524 . denotes .
R3446 T4416 T4392 punct .,show
R10579 T13601 T13590 punct .,induces
R10580 T13602 T13607 advcl Taken,provide
R10581 T13603 T13602 advmod together,Taken
R10582 T13604 T13607 punct ",",provide
R10583 T13605 T13606 det these,results
R11640 T14960 T14933 punct ),were
R11641 T14961 T14933 punct .,were
R299 T506 T509 amod mature,cells
R300 T507 T509 amod human,cells
R301 T508 T509 compound B,cells
R302 T509 T505 pobj cells,of
R303 T510 T503 punct ;,inhibits
R304 T511 T503 conj induction,inhibits
R305 T512 T511 prep of,induction
R306 T513 T514 compound Smad,phosphorylation
R307 T514 T512 pobj phosphorylation,of
R308 T515 T514 cc and,phosphorylation
R309 T516 T514 conj upregulation,phosphorylation
R310 T517 T514 prep of,phosphorylation
R311 T518 T520 compound Id1,Bone
R312 T519 T520 compound Background,Bone
R313 T520 T522 nmod Bone,proteins
R314 T521 T522 amod morphogenetic,proteins
R315 T522 T517 pobj proteins,of
R316 T523 T526 punct (,belong
R317 T524 T526 nsubj BMPs,belong
R318 T525 T526 punct ),belong
R319 T526 T503 ccomp belong,inhibits
R320 T527 T526 prep to,belong
R321 T528 T529 det the,TGF-β
R322 T529 T527 pobj TGF-β,to
R323 T530 T526 dobj superfamily,belong
R324 T531 T526 cc and,belong
R325 T532 T526 conj are,belong
R326 T533 T534 amod secreted,proteins
R327 T534 T532 attr proteins,are
R328 T535 T534 prep with,proteins
R329 T536 T537 amod pleiotropic,roles
R330 T537 T535 pobj roles,with
R331 T538 T537 prep in,roles
R332 T539 T542 amod many,types
R333 T540 T542 amod different,types
R334 T541 T542 compound cell,types
R335 T542 T538 pobj types,in
R336 T543 T503 punct .,inhibits
R337 T544 T546 det A,role
R338 T545 T546 amod potential,role
R339 T546 T555 nsubjpass role,implied
R340 T547 T546 prep of,role
R341 T548 T547 pobj BMP-6,of
R342 T549 T546 prep in,role
R343 T550 T552 det the,system
R344 T551 T552 amod immune,system
R345 T552 T549 pobj system,in
R346 T553 T555 aux has,implied
R347 T554 T555 auxpass been,implied
R348 T555 T555 ROOT implied,implied
R349 T556 T555 agent by,implied
R350 T557 T558 amod various,studies
R351 T558 T556 pobj studies,by
R352 T559 T558 prep of,studies
R353 T560 T563 amod malignant,diseases
R354 T561 T560 cc and,malignant
R355 T562 T560 conj rheumatoid,malignant
R356 T563 T559 pobj diseases,of
R357 T564 T555 punct .,implied
R358 T565 T571 prep In,explored
R359 T566 T568 det the,study
R360 T567 T568 amod present,study
R361 T568 T565 pobj study,In
R362 T569 T571 punct ",",explored
R363 T570 T571 nsubj we,explored
R364 T571 T571 ROOT explored,explored
R365 T572 T573 det the,role
R366 T573 T571 dobj role,explored
R367 T574 T573 prep of,role
R368 T575 T574 pobj BMP-6,of
R369 T576 T573 prep in,role
R370 T577 T582 amod normal,cells
R371 T578 T579 amod human,peripheral
R372 T579 T580 compound peripheral,blood
R373 T580 T582 compound blood,cells
R374 T581 T582 compound B,cells
R375 T582 T576 pobj cells,in
R376 T583 T571 punct .,explored
R377 T584 T589 nsubjpass Results,found
R378 T585 T587 det The,cells
R379 T586 T587 compound B,cells
R380 T587 T589 nsubjpass cells,found
R381 T588 T589 auxpass were,found
R382 T589 T589 ROOT found,found
R383 T590 T591 aux to,express
R384 T591 T589 advcl express,found
R385 T592 T593 compound BMP,type
R386 T593 T591 dobj type,express
R387 T594 T602 nsubj I,induced
R388 T595 T594 cc and,I
R389 T596 T598 compound type,receptors
R390 T597 T598 compound II,receptors
R391 T598 T594 conj receptors,I
R392 T599 T598 cc and,receptors
R393 T600 T598 conj BMP-6,receptors
R394 T601 T602 advmod rapidly,induced
R395 T602 T602 ROOT induced,induced
R396 T603 T602 dobj phosphorylation,induced
R397 T604 T603 prep of,phosphorylation
R398 T605 T604 pobj Smad1/5/8,of
R399 T606 T602 punct .,induced
R400 T607 T611 advmod Furthermore,followed
R401 T608 T611 punct ",",followed
R402 T609 T611 nsubjpass Smad-phosphorylation,followed
R403 T610 T611 auxpass was,followed
R404 T611 T611 ROOT followed,followed
R405 T612 T611 agent by,followed
R406 T613 T612 pobj upregulation,by
R407 T614 T613 prep of,upregulation
R408 T615 T616 compound Id1,mRNA
R409 T616 T614 pobj mRNA,of
R410 T617 T616 cc and,mRNA
R411 T618 T619 compound Id1,protein
R412 T619 T616 conj protein,mRNA
R413 T620 T611 punct ",",followed
R414 T621 T628 mark whereas,affected
R415 T622 T628 nsubjpass Id2,affected
R416 T623 T622 cc and,Id2
R417 T624 T625 compound Id3,expression
R418 T625 T628 nsubjpass expression,affected
R419 T626 T628 auxpass was,affected
R420 T627 T628 neg not,affected
R421 T628 T611 advcl affected,followed
R422 T629 T611 punct .,followed
R423 T630 T633 advmod Furthermore,found
R424 T631 T633 punct ",",found
R425 T632 T633 nsubj we,found
R426 T633 T633 ROOT found,found
R427 T634 T636 mark that,had
R428 T635 T636 nsubj BMP-6,had
R429 T636 T633 ccomp had,found
R430 T637 T639 det an,effect
R431 T638 T639 amod antiproliferative,effect
R432 T639 T636 dobj effect,had
R433 T640 T641 advmod both,in
R434 T641 T639 prep in,effect
R435 T642 T641 pobj naïve,in
R436 T643 T642 punct (,naïve
R437 T644 T652 nummod CD19,cells
R438 T645 T652 nummod +,cells
R439 T646 T652 nmod CD27,cells
R440 T647 T646 punct -,CD27
R441 T648 T646 punct ),CD27
R442 T649 T646 cc and,CD27
R443 T650 T651 compound memory,B
R444 T651 T646 conj B,CD27
R445 T652 T642 appos cells,naïve
R446 T653 T652 punct (,cells
R447 T654 T657 nummod CD19,+
R448 T655 T657 nummod +,+
R449 T656 T657 compound CD27,+
R450 T657 T652 appos +,cells
R451 T658 T652 punct ),cells
R452 T659 T652 acl stimulated,cells
R453 T660 T659 prep with,stimulated
R454 T661 T660 pobj anti-IgM,with
R455 T662 T661 advmod alone,anti-IgM
R456 T663 T661 cc or,anti-IgM
R457 T664 T666 det the,action
R458 T665 T666 amod combined,action
R459 T666 T661 conj action,anti-IgM
R460 T667 T666 prep of,action
R461 T668 T667 pobj anti-IgM,of
R462 T669 T668 cc and,anti-IgM
R480 T687 T688 amod antiproliferative,effect
R481 T688 T695 nsubjpass effect,neutralized
R482 T689 T688 prep of,effect
R483 T690 T689 pobj BMP-6,of
R484 T691 T690 prep in,BMP-6
R485 T692 T691 pobj B-cells,in
R486 T693 T695 auxpass was,neutralized
R487 T694 T695 advmod completely,neutralized
R488 T695 T695 ROOT neutralized,neutralized
R489 T696 T695 agent by,neutralized
R490 T697 T699 det the,antagonist
R491 T698 T699 amod natural,antagonist
R492 T699 T696 pobj antagonist,by
R493 T700 T699 punct ",",antagonist
R494 T701 T699 appos noggin,antagonist
R495 T702 T695 punct .,neutralized
R496 T703 T708 advmod Furthermore,demonstrated
R497 T704 T708 punct ",",demonstrated
R498 T705 T706 compound B,cells
R499 T706 T708 nsubjpass cells,demonstrated
R500 T707 T708 auxpass were,demonstrated
R501 T708 T708 ROOT demonstrated,demonstrated
R502 T709 T710 aux to,upregulate
R503 T710 T708 xcomp upregulate,demonstrated
R504 T711 T712 compound BMP-6,mRNA
R505 T712 T710 dobj mRNA,upregulate
R506 T713 T710 prep upon,upregulate
R507 T714 T713 pobj stimulation,upon
R508 T715 T710 prep with,upregulate
R509 T716 T715 pobj anti-IgM,with
R510 T717 T708 punct .,demonstrated
R511 T718 T718 ROOT Conclusion,Conclusion
R512 T719 T726 prep In,inhibited
R513 T720 T723 amod mature,cells
R514 T721 T723 amod human,cells
R515 T722 T723 compound B,cells
R516 T723 T719 pobj cells,In
R517 T724 T726 punct ",",inhibited
R518 T725 T726 nsubj BMP-6,inhibited
R519 T726 T726 ROOT inhibited,inhibited
R520 T727 T728 compound cell,growth
R521 T728 T726 dobj growth,inhibited
R522 T729 T726 punct ",",inhibited
R523 T730 T726 cc and,inhibited
R524 T731 T732 advmod rapidly,induced
R1326 T1736 T1730 conj β,Members
R1327 T1737 T1738 punct (,TGF-β
R1328 T1738 T1736 appos TGF-β,β
R1329 T1739 T1736 punct ),β
R1330 T1740 T1741 advmod superfamily,play
R1331 T1741 T1741 ROOT play,play
R1332 T1742 T1743 amod central,roles
R1333 T1743 T1741 dobj roles,play
R1334 T1744 T1741 prep in,play
R1335 T1745 T1744 pcomp controlling,in
R1336 T1746 T1747 amod cellular,proliferation
R1337 T1747 T1745 dobj proliferation,controlling
R1352 T1762 T1785 ccomp divided,constitute
R1353 T1763 T1762 prep into,divided
R1354 T1764 T1765 nummod three,subgroups
R1355 T1765 T1763 pobj subgroups,into
R1356 T1766 T1765 punct :,subgroups
R1357 T1767 T1765 appos TGF-β,subgroups
R1358 T1768 T1767 punct ",",TGF-β
R1359 T1769 T1770 det the,activins/inhibins
R1360 T1770 T1767 conj activins/inhibins,TGF-β
R1361 T1771 T1770 punct ",",activins/inhibins
R1362 T1772 T1770 cc and,activins/inhibins
R1363 T1773 T1776 det the,proteins
R1364 T1774 T1776 nmod bone,proteins
R1365 T1775 T1776 amod morphogenetic,proteins
R1366 T1776 T1770 conj proteins,activins/inhibins
R1367 T1777 T1778 punct (,BMPs
R1368 T1778 T1776 appos BMPs,proteins
R1369 T1779 T1776 punct ),proteins
R1370 T1780 T1776 punct ",",proteins
R1371 T1781 T1785 prep of,constitute
R1372 T1782 T1781 pobj which,of
R1373 T1783 T1784 det the,latter
R1374 T1784 T1785 nsubj latter,constitute
R1375 T1785 T1785 ROOT constitute,constitute
R1376 T1786 T1788 det the,family
R1377 T1787 T1788 amod largest,family
R1378 T1788 T1785 dobj family,constitute
R1379 T1789 T1785 punct .,constitute
R1380 T1790 T1791 nsubj BMPs,are
R1381 T1791 T1791 ROOT are,are
R1382 T1792 T1799 nummod 30,proteins
R1383 T1793 T1795 nummod 38,hetero
R1384 T1794 T1795 compound kDa,hetero
R1385 T1795 T1799 nmod hetero,proteins
R1386 T1796 T1795 punct -,hetero
R1387 T1797 T1795 cc or,hetero
R1388 T1798 T1799 amod homodimeric,proteins
R1389 T1799 T1791 attr proteins,are
R1390 T1800 T1801 advmod originally,identified
R1391 T1801 T1799 acl identified,proteins
R1392 T1802 T1801 agent by,identified
R1393 T1803 T1804 poss their,ability
R1394 T1804 T1802 pobj ability,by
R1395 T1805 T1806 aux to,induce
R1396 T1806 T1804 acl induce,ability
R1397 T1807 T1808 amod ectopic,cartilage
R1398 T1808 T1806 dobj cartilage,induce
R1399 T1809 T1808 cc and,cartilage
R1400 T1810 T1811 compound bone,formation
R1401 T1811 T1808 conj formation,cartilage
R1402 T1812 T1814 compound [,]
R1416 T1826 T1822 prep during,role
R1417 T1827 T1826 pobj embryogenesis,during
R1418 T1828 T1819 punct ",",demonstrated
R1419 T1829 T1819 cc and,demonstrated
R1420 T1830 T1831 advmod more,recently
R1421 T1831 T1837 advmod recently,[
R1422 T1832 T1837 punct ",",[
R1423 T1833 T1834 advmod also,in
R1424 T1834 T1837 prep in,[
R1425 T1835 T1836 compound adult,tissues
R1426 T1836 T1834 pobj tissues,in
R1427 T1837 T1819 conj [,demonstrated
R1428 T1838 T1839 nummod 1,]
R1429 T1839 T1837 dobj ],[
R1430 T1840 T1819 punct .,demonstrated
R1431 T1841 T1845 nsubjpass TGF-β,studied
R1432 T1842 T1845 aux has,studied
R1433 T1843 T1845 auxpass been,studied
R1434 T1844 T1845 advmod intensively,studied
R1435 T1845 T1845 ROOT studied,studied
R1436 T1846 T1845 prep in,studied
R1437 T1847 T1851 amod normal,cells
R1438 T1848 T1847 cc and,normal
R1439 T1849 T1847 conj malignant,normal
R1440 T1850 T1851 amod haematopoietic,cells
R1441 T1851 T1846 pobj cells,in
R1442 T1852 T1845 cc and,studied
R1443 T1853 T1845 conj is,studied
R1444 T1854 T1853 attr one,is
R1445 T1855 T1854 prep of,one
R1446 T1856 T1861 det the,regulators
R1447 T1857 T1858 advmod most,potent
R1448 T1858 T1861 amod potent,regulators
R1449 T1859 T1861 amod endogenous,regulators
R1450 T1860 T1861 amod negative,regulators
R1451 T1861 T1855 pobj regulators,of
R1452 T1862 T1861 acl known,regulators
R1453 T1863 T1862 prep to,known
R1454 T1864 T1863 pobj date,to
R1455 T1865 T1845 punct .,studied
R1456 T1866 T1866 ROOT [,[
R1457 T1867 T1866 nummod 4,[
R1458 T1868 T1868 ROOT ],]
R1459 T1869 T1866 punct .,[
R1460 T1870 T1885 prep In,investigated
R1461 T1871 T1870 pobj contrast,In
R1462 T1872 T1885 punct ",",investigated
R1463 T1873 T1874 det the,effect
R1464 T1874 T1885 nsubj effect,investigated
R1465 T1875 T1874 prep of,effect
R1466 T1876 T1875 pobj BMPs,of
R1467 T1877 T1876 prep in,BMPs
R1468 T1878 T1880 det the,system
R1469 T1879 T1880 amod immune,system
R1470 T1880 T1877 pobj system,in
R1471 T1881 T1885 aux has,investigated
R1472 T1882 T1885 neg not,investigated
R1473 T1883 T1885 auxpass been,investigated
R1474 T1884 T1885 advmod widely,investigated
R1475 T1885 T1885 ROOT investigated,investigated
R1476 T1886 T1885 punct .,investigated
R1477 T1887 T1900 prep In,found
R1478 T1888 T1889 det that,respect
R1479 T1889 T1887 pobj respect,In
R1480 T1890 T1900 punct ",",found
R1481 T1891 T1900 nsubjpass BMP,found
R1482 T1892 T1893 punct -,2
R1483 T1893 T1891 nummod 2,BMP
R1484 T1894 T1891 punct ",",BMP
R1485 T1895 T1891 nummod -4,BMP
R1486 T1896 T1891 cc and,BMP
R1487 T1897 T1891 conj -7,BMP
R1488 T1898 T1900 aux have,found
R1489 T1899 T1900 auxpass been,found
R1490 T1900 T1900 ROOT found,found
R1491 T1901 T1902 aux to,control
R1492 T1902 T1900 xcomp control,found
R1493 T1903 T1902 dobj differentiation,control
R1494 T1904 T1903 prep of,differentiation
R1495 T1905 T1907 amod hematopoietic,cells
R1496 T1906 T1907 compound stem,cells
R1497 T1907 T1904 pobj cells,of
R1498 T1908 T1910 nmod [,]
R1499 T1909 T1910 nummod 5,]
R1500 T1910 T1902 dobj ],control
R1501 T1911 T1910 cc and,]
R1502 T1912 T1915 amod early,development
R1503 T1913 T1915 compound T,development
R1504 T1914 T1915 compound cell,development
R1505 T1915 T1910 conj development,]
R1506 T1916 T1918 nmod [,]
R1507 T1917 T1918 nummod "6,7",]
R1508 T1918 T1910 conj ],]
R1509 T1919 T1900 punct .,found
R1510 T1920 T1923 nsubjpass BMP-6,reported
R1511 T1921 T1923 aux has,reported
R1512 T1922 T1923 auxpass been,reported
R1513 T1923 T1923 ROOT reported,reported
R1514 T1924 T1925 aux to,reduce
R1515 T1925 T1923 xcomp reduce,reported
R1516 T1926 T1927 det the,number
R1517 T1927 T1925 dobj number,reduce
R1518 T1928 T1927 prep of,number
R1519 T1929 T1930 amod cobblestone-area-forming,cells
R1520 T1930 T1928 pobj cells,of
R1521 T1931 T1930 prep of,cells
R1522 T1932 T1935 amod normal,cells
R1523 T1933 T1935 amod human,cells
R1524 T1934 T1935 amod haematopoietic,cells
R1525 T1935 T1931 pobj cells,of
R1526 T1936 T1925 conj [,reduce
R1527 T1937 T1938 nummod 8,]
R1528 T1938 T1936 dobj ],[
R1529 T1939 T1923 punct .,reported
R1530 T1940 T1949 advmod Furthermore,had
R1531 T1941 T1949 punct ",",had
R1532 T1942 T1949 nsubj BMP-2,had
R1533 T1943 T1942 punct ",",BMP-2
R1534 T1944 T1949 nsubj -4,had
R1535 T1945 T1946 punct ",",6
R1536 T1946 T1944 prep 6,-4
R1539 T1949 T1949 ROOT had,had
R1540 T1950 T1951 det an,antiproliferative
R1541 T1951 T1949 dobj antiproliferative,had
R1542 T1952 T1951 cc and,antiproliferative
R1543 T1953 T1955 det a,effect
R1544 T1954 T1955 amod proapoptotic,effect
R1545 T1955 T1951 conj effect,antiproliferative
R1546 T1956 T1955 prep on,effect
R1547 T1957 T1959 amod multiple,cells
R1548 T1958 T1959 compound myeloma,cells
R1549 T1959 T1956 pobj cells,on
R1550 T1960 T1962 compound [,]
R1551 T1961 T1962 compound 9-11,]
R1552 T1962 T1959 appos ],cells
R1553 T1963 T1949 punct .,had
R1554 T1964 T1974 prep In,increased
R1555 T1965 T1964 pobj addition,In
R1556 T1966 T1974 punct ",",increased
R1557 T1967 T1974 prep by,increased
R1558 T2004 T2003 punct ",",BMP-6
R1559 T1968 T1969 compound gene,expression
R1560 T2005 T2003 prep like,BMP-6
R1561 T2006 T2009 det the,members
R1562 T1969 T1967 pobj expression,by
R1563 T2007 T2009 amod other,members
R1564 T2008 T2009 compound BMP,members
R1565 T1970 T1974 advmod profiling,increased
R1566 T2009 T2005 pobj members,like
R1567 T2010 T2009 punct ",",members
R1568 T2011 T2011 ROOT signals,signals
R1569 T2012 T2011 prep through,signals
R1570 T2013 T2012 pobj ligation,through
R1571 T2014 T2013 cc and,ligation
R1572 T1971 T1974 punct ",",increased
R1573 T2015 T2013 conj heterodimerzation,ligation
R1574 T2016 T2015 prep of,heterodimerzation
R1575 T2017 T2018 compound BMP,type
R1576 T1972 T1974 nsubj BMP-6,increased
R1577 T2018 T2016 pobj type,of
R1578 T2019 T2020 nsubj I,[
R1579 T2020 T2011 advcl [,signals
R1580 T1973 T1974 advmod significantly,increased
R1581 T2021 T2020 acomp activin-like-kinase,[
R1582 T2022 T2021 punct (,activin-like-kinase
R1583 T2023 T2021 appos ALK,activin-like-kinase
R1584 T1974 T1974 ROOT increased,increased
R1585 T2024 T2023 punct ),ALK
R1586 T2025 T2021 conj ],activin-like-kinase
R1587 T2026 T2025 cc and,]
R1588 T2027 T2031 nmod type,receptors
R1589 T1975 T1977 det the,value
R1590 T2028 T2031 nmod II,receptors
R1591 T2029 T2031 amod serine-threonine,receptors
R1592 T1976 T1977 amod predictive,value
R1593 T2030 T2031 compound kinase,receptors
R1594 T2031 T2025 conj receptors,]
R1595 T2032 T2031 punct ",",receptors
R1596 T1977 T1974 dobj value,increased
R1597 T2033 T2035 nsubj which,propagates
R1598 T2034 T2035 advmod subsequently,propagates
R1599 T2035 T2031 relcl propagates,receptors
R1600 T2036 T2037 det the,signal
R1601 T1978 T1974 prep for,increased
R1602 T2037 T2035 dobj signal,propagates
R1603 T2038 T2037 amod downstream,signal
R1604 T2039 T2035 prep by,propagates
R1605 T2040 T2039 pcomp phosphorylating,by
R1606 T1979 T1982 det a,test
R1607 T2041 T2042 compound Smad,proteins
R1608 T2042 T2040 dobj proteins,phosphorylating
R1609 T2043 T2020 punct .,[
R1610 T1980 T1982 amod multi-gene,test
R1611 T2044 T2046 nsubj BMP-6,signal
R1612 T2045 T2046 aux can,signal
R1613 T2046 T2046 ROOT signal,signal
R1614 T1981 T1982 compound signature,test
R1615 T2047 T2046 prep through,signal
R1616 T2048 T2049 det the,ligation
R1617 T2049 T2047 pobj ligation,through
R1618 T2050 T2049 prep of,ligation
R1619 T2051 T2052 det the,type
R1620 T2052 T2050 pobj type,of
R1621 T1982 T1978 pobj test,for
R1622 T1983 T1974 cc and,increased
R1623 T2053 T2054 nsubj I,receptors
R1624 T1984 T1985 auxpass was,associated
R1625 T2054 T2052 relcl receptors,type
R1626 T1985 T1974 conj associated,increased
R1627 T2055 T2054 dobj Act-RIA,receptors
R1628 T1986 T1985 prep with,associated
R1629 T1987 T1989 det a,outcome
R1630 T2056 T2055 punct ",",Act-RIA
R1631 T1988 T1989 amod poor,outcome
R1632 T1989 T1986 pobj outcome,with
R1633 T2057 T2055 conj BMP-RIA,Act-RIA
R1634 T1990 T1989 prep in,outcome
R1635 T2058 T2057 punct ",",BMP-RIA
R1636 T2059 T2057 cc and,BMP-RIA
R1637 T1991 T1990 pobj diffuse,in
R1638 T2060 T2057 conj BMP-RIB,BMP-RIA
R1639 T2061 T2060 cc and,BMP-RIB
R1640 T2062 T2065 det the,receptors
R1641 T1992 T1995 amod large,lymphomas
R1642 T2063 T2065 compound type,receptors
R1643 T2064 T2065 compound II,receptors
R1644 T2065 T2054 conj receptors,receptors
R1645 T1993 T1994 compound B,cell
R1646 T2066 T2054 npadvmod BMP-RII,receptors
R1647 T2067 T2066 punct ",",BMP-RII
R1648 T2068 T2066 conj Act-RIIA,BMP-RII
R1649 T1994 T1995 compound cell,lymphomas
R1650 T2069 T2068 cc and,Act-RIIA
R1651 T2070 T2068 conj Act-RIIB,Act-RIIA
R1652 T1995 T1991 dobj lymphomas,diffuse
R1653 T2071 T2066 punct ",",BMP-RII
R1654 T2072 T2073 nsubj which,lead
R1655 T1996 T1997 punct (,DLBCL
R1656 T1997 T1995 appos DLBCL,lymphomas
R1657 T2073 T2066 relcl lead,BMP-RII
R1658 T2074 T2073 prep to,lead
R1659 T2075 T2076 det the,phosphorylation
R1660 T1998 T1985 punct ),associated
R1661 T2076 T2074 pobj phosphorylation,to
R1662 T2077 T2076 prep of,phosphorylation
R1663 T2078 T2080 det the,Smads
R1664 T1999 T2001 nmod [,]
R1665 T2079 T2080 compound receptor,Smads
R1666 T2080 T2077 pobj Smads,of
R1667 T2081 T2082 punct (,Smad-1
R1668 T2082 T2076 appos Smad-1,phosphorylation
R1669 T2083 T2082 punct ",",Smad-1
R1670 T2084 T2082 conj Smad-5,Smad-1
R1671 T2000 T2001 nummod 12,]
R1672 T2085 T2084 punct ",",Smad-5
R1673 T2086 T2084 cc and,Smad-5
R1674 T2087 T2084 conj Smad-8,Smad-5
R1675 T2088 T2084 punct ),Smad-5
R1676 T2001 T2001 ROOT ],]
R1677 T2089 T2046 punct .,signal
R1678 T2090 T2093 det The,Smads
R1679 T2091 T2093 compound R,Smads
R1680 T2002 T2001 punct .,]
R1681 T2092 T2093 punct -,Smads
R1682 T2093 T2095 nsubj Smads,form
R1683 T2094 T2095 advmod then,form
R1684 T2003 T2011 nsubj BMP-6,signals
R1685 T2095 T2095 ROOT form,form
R1686 T2096 T2095 dobj complexes,form
R1687 T2097 T2096 prep with,complexes
R1688 T2101 T2099 appos Smad4,co-Smad
R1689 T2098 T2099 det the,co-Smad
R1690 T2099 T2097 pobj co-Smad,with
R1691 T2100 T2099 punct (,co-Smad
R1692 T2102 T2099 punct ),co-Smad
R1693 T2103 T2095 cc and,form
R1694 T2104 T2105 auxpass are,translocated
R1695 T2198 T2199 advmod also,were
R1696 T2105 T2095 conj translocated,form
R1697 T2199 T2194 ccomp were,investigated
R1698 T2200 T2199 acomp capable,were
R1699 T2201 T2200 prep of,capable
R1700 T2106 T2105 prep into,translocated
R1701 T2202 T2201 pcomp producing,of
R1702 T2203 T2202 dobj BMP-6,producing
R1703 T2107 T2108 det the,nucleus
R1704 T2108 T2106 pobj nucleus,into
R1705 T2204 T2194 punct .,investigated
R1708 T2111 T2108 relcl exert,nucleus
R1709 T2112 T2113 compound gene,regulation
R1710 T2113 T2116 compound regulation,]
R1711 T2114 T2116 compound [,]
R1712 T2115 T2116 compound "1,13",]
R1713 T2116 T2111 dobj ],exert
R1714 T2117 T2095 punct .,form
R1715 T2118 T2133 prep Given,wanted
R1723 T2126 T2124 pobj malignancies,in
R1724 T2127 T2126 cc and,malignancies
R1725 T2128 T2130 amod haematopoietic,cells
R1726 T2129 T2130 compound progenitor,cells
R1727 T2130 T2126 conj cells,malignancies
R1728 T2131 T2133 punct ",",wanted
R1729 T2132 T2133 nsubj we,wanted
R1730 T2133 T2133 ROOT wanted,wanted
R1731 T2134 T2135 aux to,explore
R1732 T2135 T2133 xcomp explore,wanted
R1734 T2136 T2138 poss its,role
R1741 T2137 T2138 amod potential,role
R1745 T2138 T2135 dobj role,explore
R1748 T2139 T2138 prep in,role
R1749 T2140 T2143 amod normal,cells
R1751 T2141 T2143 amod human,cells
R1752 T2142 T2143 compound B,cells
R1755 T2143 T2139 pobj cells,in
R1759 T2144 T2133 punct .,wanted
R1763 T2145 T2146 nsubj We,studied
R1765 T2146 T2146 ROOT studied,studied
R1766 T2147 T2148 det the,effects
R1772 T2148 T2146 dobj effects,studied
R1776 T2149 T2148 prep of,effects
R1777 T2150 T2149 pobj BMP-6,of
R1784 T2151 T2148 prep on,effects
R1785 T2152 T2151 pobj proliferation,on
R1787 T2153 T2152 cc and,proliferation
R1789 T2154 T2152 conj apoptosis,proliferation
R1792 T2155 T2148 prep on,effects
R1794 T2156 T2155 pcomp resting,on
R1795 T2157 T2146 cc and,studied
R1796 T2158 T2146 conj stimulated,studied
R1797 T2159 T2160 compound B,cells
R1798 T2160 T2158 dobj cells,stimulated
R1799 T2161 T2146 punct .,studied
R1800 T2162 T2171 advmod Furthermore,induced
R1801 T2163 T2171 punct ",",induced
R1802 T2164 T2165 det the,expression
R1803 T2165 T2171 nsubj expression,induced
R1805 T2166 T2165 prep of,expression
R1808 T2167 T2168 compound BMP,receptors
R1810 T2168 T2166 pobj receptors,of
R1828 T2169 T2168 cc and,receptors
R1838 T2170 T2171 nsubj BMP-6,induced
R1841 T2171 T2171 ROOT induced,induced
R1843 T2172 T2171 dobj activation,induced
R1844 T2173 T2172 prep of,activation
R1845 T2174 T2177 det the,pathway
R1846 T2175 T2177 nmod Smad,pathway
R1847 T2176 T2177 amod signalling,pathway
R1848 T2177 T2173 pobj pathway,of
R1849 T2178 T2171 prep with,induced
R1880 T2179 T2180 amod subsequent,regulation
R1884 T2180 T2178 pobj regulation,with
R1885 T2181 T2180 prep of,regulation
R1886 T2182 T2184 det the,genes
R1889 T2183 T2184 compound target,genes
R1891 T2184 T2181 pobj genes,of
R1895 T2185 T2186 compound Id1,Id4
R1897 T2186 T2171 npadvmod Id4,induced
R1899 T2187 T2171 punct ",",induced
R1900 T2188 T2189 auxpass were,resolved
R1901 T2189 T2171 conj resolved,induced
R1902 T2190 T2171 punct .,induced
R1903 T2191 T2194 advmod Finally,investigated
R1904 T2192 T2194 punct ",",investigated
R1905 T2193 T2194 nsubj we,investigated
R1906 T2194 T2194 ROOT investigated,investigated
R1907 T2195 T2199 mark whether,were
R1908 T2196 T2197 compound B,cells
R1909 T2197 T2199 nsubj cells,were
R2435 T3082 T3083 nummod BMP-6,inhibits
R2436 T3083 T3101 nsubj inhibits,prompted
R2437 T3084 T3085 nsubj anti-IgM,induced
R2438 T3085 T3083 relcl induced,inhibits
R2439 T3086 T3085 dobj proliferation,induced
R2440 T3087 T3086 prep of,proliferation
R2441 T3088 T3090 amod human,cells
R2442 T3089 T3090 compound B,cells
R2443 T3090 T3087 pobj cells,of
R2444 T3091 T3092 det The,effects
R2445 T3092 T3101 nsubj effects,prompted
R2446 T3093 T3092 prep of,effects
R2447 T3094 T3093 pobj BMP-6,of
R2448 T3095 T3092 prep on,effects
R2449 T3096 T3100 amod normal,cells
R2450 T3097 T3096 cc and,normal
R2451 T3098 T3096 conj neoplastic,normal
R2452 T3099 T3100 amod hematopoietic,cells
R2453 T3100 T3095 pobj cells,on
R2454 T3101 T3101 ROOT prompted,prompted
R2455 T3102 T3101 dobj us,prompted
R2456 T3103 T3104 aux to,investigate
R2457 T3104 T3101 xcomp investigate,prompted
R2458 T3105 T3106 det the,effects
R2459 T3106 T3104 dobj effects,investigate
R2460 T3107 T3106 prep of,effects
R2461 T3108 T3107 pobj BMP-6,of
R2462 T3109 T3106 prep on,effects
R2463 T3110 T3113 amod normal,cells
R2464 T3111 T3113 amod human,cells
R2465 T3112 T3113 compound B,cells
R2466 T3113 T3109 pobj cells,on
R2467 T3114 T3101 punct .,prompted
R2468 T3115 T3116 det All,experiments
R2469 T3116 T3121 nsubjpass experiments,performed
R2470 T3117 T3116 prep in,experiments
R2471 T3118 T3119 det this,study
R2472 T3119 T3117 pobj study,in
R2473 T3120 T3121 auxpass were,performed
R2474 T3121 T3121 ROOT performed,performed
R2475 T3122 T3121 prep under,performed
R2476 T3123 T3124 amod serum-free,conditions
R2477 T3124 T3122 pobj conditions,under
R2478 T3125 T3129 mark as,shown
R2479 T3126 T3129 nsubjpass FCS,shown
R2480 T3127 T3129 aux has,shown
R2481 T3128 T3129 auxpass been,shown
R2482 T3129 T3121 advcl shown,performed
R2483 T3130 T3131 aux to,interfere
R2484 T3131 T3129 xcomp interfere,shown
R2485 T3132 T3131 prep with,interfere
R2486 T3133 T3136 amod BMP-signalling,]
R2487 T3134 T3136 nmod [,]
R2488 T3135 T3136 nummod 14,]
R2489 T3136 T3132 pobj ],with
R2490 T3137 T3139 punct (,observations
R2491 T3138 T3139 amod own,observations
R2492 T3139 T3136 appos observations,]
R2493 T3140 T3136 punct ),]
R2494 T3141 T3121 punct .,performed
R2495 T3142 T3143 aux To,study
R2496 T3143 T3151 advcl study,B-cells
R2497 T3144 T3145 det the,effect
R2498 T3145 T3143 dobj effect,study
R2499 T3146 T3145 prep of,effect
R2500 T3147 T3146 pobj BMP-6,of
R2501 T3148 T3147 prep on,BMP-6
R2502 T3149 T3148 pobj proliferation,on
R2503 T3150 T3151 punct ",",B-cells
R2504 T3151 T3156 nsubjpass B-cells,stimulated
R2505 T3152 T3151 prep from,B-cells
R2506 T3153 T3154 amod healthy,volunteers
R2507 T3154 T3152 pobj volunteers,from
R2508 T3155 T3156 auxpass were,stimulated
R2509 T3156 T3156 ROOT stimulated,stimulated
R2510 T3157 T3156 prep with,stimulated
R2511 T3158 T3157 pobj anti-IgM,with
R2512 T3159 T3158 cc and/or,anti-IgM
R2513 T3160 T3158 nummod CD40L,anti-IgM
R2514 T3161 T3156 prep in,stimulated
R2515 T3162 T3163 det the,presence
R2516 T3163 T3161 pobj presence,in
R2517 T3164 T3163 cc or,presence
R2518 T3165 T3163 conj absence,presence
R2519 T3166 T3165 prep of,absence
R2520 T3167 T3166 pobj BMP-6,of
R2521 T3168 T3156 prep for,stimulated
R2522 T3169 T3170 nummod three,days
R2523 T3170 T3168 pobj days,for
R2524 T3171 T3156 punct .,stimulated
R2525 T3172 T3173 nsubj We,found
R2526 T3173 T3173 ROOT found,found
R2527 T3174 T3176 mark that,led
R2528 T3175 T3176 nsubj BMP-6,led
R2529 T3176 T3173 ccomp led,found
R2530 T3177 T3176 prep to,led
R2531 T3178 T3182 det a,reduction
R2532 T3179 T3180 nummod 35,%
R2533 T3180 T3181 nsubj %,mean
R2534 T3181 T3182 amod mean,reduction
R2535 T3182 T3177 pobj reduction,to
R2536 T3183 T3182 prep of,reduction
R2537 T3184 T3183 pobj anti-IgM,of
R2538 T3185 T3182 punct -,reduction
R2539 T3186 T3182 acl induced,reduction
R2540 T3187 T3188 compound DNA,synthesis
R2541 T3188 T3186 dobj synthesis,induced
R2542 T3189 T3196 punct (,0.0002
R2543 T3190 T3192 advmod n,8
R2544 T3191 T3192 punct =,8
R2545 T3192 T3195 nummod 8,≤
R2546 T3193 T3194 punct ;,p
R2547 T3194 T3195 compound p,≤
R2548 T3195 T3196 compound ≤,0.0002
R2549 T3196 T3188 appos 0.0002,synthesis
R2550 T3197 T3196 punct ",",0.0002
R2551 T3198 T3199 compound Figure,1A
R2552 T3199 T3196 appos 1A,0.0002
R2553 T3200 T3196 punct ),0.0002
R2554 T3201 T3173 punct .,found
R2555 T3202 T3203 amod Similar,results
R2556 T3203 T3205 nsubjpass results,obtained
R2557 T3204 T3205 auxpass were,obtained
R2558 T3205 T3205 ROOT obtained,obtained
R2559 T3206 T3205 prep for,obtained
R2560 T3207 T3208 compound B,cells
R2561 T3208 T3206 pobj cells,for
R2562 T3209 T3208 acl treated,cells
R2563 T3210 T3209 prep with,treated
R2564 T3211 T3210 pobj anti-IgM,with
R2565 T3212 T3211 cc and,anti-IgM
R2566 T3213 T3211 conj CD40L,anti-IgM
R2567 T3214 T3217 punct (,mean
R2568 T3215 T3216 nummod 26,%
R2569 T3216 T3217 nsubj %,mean
R2570 T3217 T3213 parataxis mean,CD40L
R2571 T3218 T3217 dobj reduction,mean
R2572 T3219 T3224 punct ",",p
R2573 T3220 T3224 advcl n,p
R2574 T3221 T3222 punct =,6
R2575 T3222 T3220 prep 6,n
R2576 T3223 T3224 punct ;,p
R2577 T3224 T3217 dep p,mean
R2578 T3225 T3224 dobj ≤,p
R2579 T3226 T3225 nummod 0.023,≤
R2580 T3227 T3217 punct ),mean
R2581 T3228 T3205 punct .,obtained
R2582 T3229 T3231 det The,inhibition
R2583 T3230 T3231 amod BMP-6-induced,inhibition
R2584 T3231 T3234 nsubj inhibition,was
R2585 T3232 T3231 prep of,inhibition
R2586 T3233 T3232 pobj proliferation,of
R2587 T3234 T3234 ROOT was,was
R2588 T3235 T3234 acomp dose-dependent,was
R2589 T3236 T3235 prep in,dose-dependent
R2590 T3237 T3240 det both,cells
R2591 T3238 T3240 amod peripheral,cells
R2592 T3239 T3240 compound B,cells
R2593 T3240 T3236 pobj cells,in
R2594 T3241 T3243 punct (,1B
R2595 T3242 T3243 compound Figure,1B
R2596 T3243 T3240 appos 1B,cells
R2597 T3244 T3234 punct ),was
R2598 T3245 T3234 cc and,was
R2599 T3246 T3250 det the,line
R2600 T3247 T3250 compound Burkitt,line
R2601 T3248 T3249 compound lymphoma,cell
R2602 T3249 T3250 compound cell,line
R2603 T3250 T3234 conj line,was
R2604 T3251 T3250 appos Ramos,line
R2605 T3252 T3255 punct (,reduction
R2606 T3253 T3254 nummod 40,%
R2607 T3254 T3255 compound %,reduction
R2608 T3255 T3251 parataxis reduction,Ramos
R2609 T3256 T3255 prep of,reduction
R2610 T3257 T3258 compound DNA,synthesis
R2611 T3258 T3256 pobj synthesis,of
R2612 T3259 T3251 punct ",",Ramos
R2613 T3260 T3261 compound Figure,1C
R2614 T3261 T3251 conj 1C,Ramos
R2615 T3262 T3251 punct ),Ramos
R2616 T3263 T3234 punct .,was
R2617 T3264 T3266 det The,effects
R2618 T3265 T3266 compound BMP-6,effects
R2619 T3266 T3269 nsubjpass effects,reversed
R2620 T3267 T3269 aux could,reversed
R2621 T3268 T3269 auxpass be,reversed
R2622 T3269 T3269 ROOT reversed,reversed
R2623 T3270 T3269 agent by,reversed
R2624 T3271 T3270 pobj addition,by
R2625 T3272 T3271 prep of,addition
R2626 T3273 T3276 det the,Noggin
R2627 T3274 T3276 amod extracellular,Noggin
R2628 T3275 T3276 compound inhibitor,Noggin
R2629 T3276 T3272 pobj Noggin,of
R2630 T3277 T3279 punct (,1D
R2631 T3278 T3279 compound Figure,1D
R2632 T3279 T3276 appos 1D,Noggin
R2633 T3280 T3279 punct ),1D
R2634 T3281 T3269 punct .,reversed
R2635 T3282 T3295 advmod Similarly,neutralized
R2636 T3283 T3295 punct ",",neutralized
R2637 T3284 T3285 det a,combination
R2638 T3285 T3295 nsubj combination,neutralized
R2639 T3286 T3285 prep of,combination
R2640 T3287 T3290 det the,receptors
R2641 T3288 T3290 amod soluble,receptors
R2642 T3289 T3290 compound BMP,receptors
R2643 T3290 T3286 pobj receptors,of
R2644 T3291 T3295 nsubj BMP-RIB-Fc,neutralized
R2645 T3292 T3291 cc and,BMP-RIB-Fc
R2646 T3293 T3291 conj BMP-RII-Fc,BMP-RIB-Fc
R2647 T3294 T3295 advmod also,neutralized
R2648 T3295 T3295 ROOT neutralized,neutralized
R2649 T3296 T3297 det the,effects
R2650 T3297 T3295 dobj effects,neutralized
R2651 T3298 T3297 prep of,effects
R2652 T3299 T3298 pobj BMP-6,of
R2653 T3300 T3303 punct (,shown
R2654 T3301 T3303 nsubjpass data,shown
R2655 T3302 T3303 neg not,shown
R2656 T3303 T3295 parataxis shown,neutralized
R2657 T3304 T3303 punct ),shown
R2658 T3305 T3295 punct .,neutralized
R2659 T3306 T3309 advmod Next,wanted
R2660 T3307 T3309 punct ",",wanted
R2661 T3308 T3309 nsubj we,wanted
R2662 T3309 T3309 ROOT wanted,wanted
R2663 T3310 T3311 aux to,test
R2664 T3311 T3309 xcomp test,wanted
R2665 T3312 T3314 mark whether,had
R2666 T3313 T3314 nsubj BMP-6,had
R2667 T3314 T3311 ccomp had,test
R2668 T3315 T3316 amod different,effect
R2669 T3316 T3314 dobj effect,had
R2670 T3317 T3316 prep on,effect
R2671 T3318 T3317 pobj naïve,on
R2672 T3319 T3318 cc and,naïve
R2673 T3320 T3322 compound memory,cells
R2674 T3321 T3322 compound B,cells
R2675 T3322 T3318 conj cells,naïve
R2676 T3323 T3309 punct .,wanted
R2677 T3324 T3342 nsubjpass Naïve,isolated
R2678 T3325 T3341 punct (,were
R2679 T3326 T3340 nmod CD19,cells
R2680 T3327 T3340 nmod +,cells
R2681 T3328 T3340 nmod CD27,cells
R2682 T3329 T3328 punct -,CD27
R2683 T3330 T3328 punct ),CD27
R2684 T3331 T3328 cc and,CD27
R2685 T3332 T3340 nmod memory,cells
R2686 T3333 T3332 punct (,memory
R2687 T3334 T3337 nummod CD19,+
R2688 T3335 T3337 compound +,+
R2689 T3336 T3337 compound CD27,+
R2690 T3337 T3340 compound +,cells
R2691 T3338 T3339 punct ),B
R2692 T3339 T3340 compound B,cells
R2693 T3340 T3341 nsubj cells,were
R2694 T3341 T3342 auxpass were,isolated
R2695 T3342 T3342 ROOT isolated,isolated
R2696 T3343 T3342 prep from,isolated
R2697 T3344 T3345 amod peripheral,blood
R2698 T3345 T3343 pobj blood,from
R2699 T3346 T3342 agent by,isolated
R2700 T3347 T3346 pobj cell,by
R2701 T3348 T3347 acl sorting,cell
R2702 T3349 T3348 prep of,sorting
R2703 T3350 T3354 amod immunobead-isolated,cells
R2704 T3351 T3353 compound CD19,B
R2705 T3352 T3353 compound +,B
R2706 T3353 T3354 compound B,cells
R2707 T3354 T3349 pobj cells,of
R2708 T3355 T3357 nmod [,]
R2709 T3356 T3357 nummod 15,]
R2710 T3357 T3348 dobj ],sorting
R2711 T3358 T3357 punct ",",]
R2712 T3359 T3342 cc and,isolated
R2713 T3360 T3342 conj tested,isolated
R2714 T3361 T3365 mark for,proliferate
R2715 T3362 T3363 poss their,capacity
R2716 T3363 T3365 nsubj capacity,proliferate
R2717 T3364 T3365 aux to,proliferate
R2718 T3365 T3360 advcl proliferate,tested
R2719 T3366 T3365 prep in,proliferate
R2720 T3367 T3368 det the,presence
R2721 T3368 T3366 pobj presence,in
R2722 T3369 T3368 prep of,presence
R2723 T3370 T3369 pobj BMP-6,of
R2724 T3371 T3342 punct .,isolated
R2725 T3372 T3375 advmod However,inhibited
R2726 T3373 T3375 punct ",",inhibited
R2727 T3374 T3375 nsubj BMP-6,inhibited
R2728 T3375 T3403 ccomp inhibited,p
R2729 T3376 T3377 advmod anti-IgM,induced
R2730 T3377 T3379 amod induced,synthesis
R2731 T3378 T3379 compound DNA,synthesis
R2732 T3379 T3375 dobj synthesis,inhibited
R2733 T3380 T3375 prep in,inhibited
R2734 T3381 T3383 det the,subpopulations
R2735 T3382 T3383 nummod two,subpopulations
R2736 T3383 T3380 pobj subpopulations,in
R2737 T3384 T3375 prep to,inhibited
R2738 T3385 T3387 det a,extent
R2739 T3386 T3387 amod similar,extent
R2740 T3387 T3384 pobj extent,to
R2741 T3388 T3375 punct ",",inhibited
R2742 T3389 T3375 prep with,inhibited
R2743 T3390 T3392 det a,reduction
R2744 T3391 T3392 amod mean,reduction
R2745 T3392 T3389 pobj reduction,with
R2746 T3393 T3392 prep of,reduction
R2747 T3394 T3393 pobj DNA-synthesis,of
R2748 T3395 T3394 prep of,DNA-synthesis
R2749 T3396 T3397 nummod 45,%
R2750 T3397 T3395 pobj %,of
R2751 T3398 T3401 punct (,5
R2752 T3399 T3401 advmod n,5
R2753 T3400 T3401 punct =,5
R2754 T3401 T3397 npadvmod 5,%
R2755 T3402 T3403 punct ;,p
R2756 T3403 T3403 ROOT p,p
R2757 T3404 T3403 dep ≤,p
R2758 T3405 T3404 nummod "0,004",≤
R2759 T3406 T3404 punct ),≤
R2760 T3407 T3404 prep for,≤
R2761 T3408 T3410 compound naïve,cells
R2762 T3409 T3410 compound B,cells
R2763 T3410 T3407 pobj cells,for
R2764 T3411 T3404 cc and,≤
R2765 T3412 T3413 nummod 48,%
R2766 T3413 T3404 conj %,≤
R2767 T3414 T3413 punct (,%
R2768 T3415 T3417 advmod n,5
R2769 T3416 T3417 punct =,5
R2770 T3417 T3413 appos 5,%
R2771 T3418 T3413 punct ;,%
R2772 T3419 T3404 conj p,≤
R2773 T3420 T3419 dobj ≤,p
R2774 T3421 T3420 nummod "0,001",≤
R2775 T3422 T3419 punct ),p
R2776 T3423 T3419 prep for,p
R2777 T3424 T3426 compound memory,cells
R2778 T3425 T3426 compound B,cells
R2779 T3426 T3423 pobj cells,for
R2780 T3427 T3428 punct (,Figure
R2781 T3428 T3426 appos Figure,cells
R2782 T3429 T3428 nummod 1E,Figure
R2783 T3430 T3428 punct ),Figure
R2784 T3431 T3403 punct .,p
R2954 T3786 T3787 nsubj BMP-6,induces
R2955 T3787 T3787 ROOT induces,induces
R2956 T3788 T3789 compound cell,death
R2957 T3789 T3787 dobj death,induces
R2958 T3790 T3787 prep in,induces
R2959 T3791 T3792 amod human,memory
R2960 T3792 T3794 compound memory,cells
R2961 T3793 T3794 compound B,cells
R2962 T3794 T3790 pobj cells,in
R2963 T3795 T3794 cc and,cells
R2964 T3796 T3797 compound Ramos,cells
R2965 T3797 T3794 conj cells,cells
R2966 T3798 T3801 advmod Next,wanted
R2967 T3799 T3801 punct ",",wanted
R2968 T3800 T3801 nsubj we,wanted
R2969 T3801 T3787 advcl wanted,induces
R2970 T3802 T3803 aux to,establish
R2971 T3803 T3801 xcomp establish,wanted
R2972 T3804 T3808 mark whether,affect
R2973 T3805 T3808 nsubj BMP-6,affect
R2974 T3806 T3808 advmod also,affect
R2975 T3807 T3808 aux could,affect
R2976 T3808 T3803 ccomp affect,establish
R2977 T3809 T3810 det the,viability
R2978 T3810 T3808 dobj viability,affect
R2979 T3811 T3810 prep of,viability
R2980 T3812 T3814 amod normal,cells
R2981 T3813 T3814 compound B,cells
R2982 T3814 T3811 pobj cells,of
R2983 T3815 T3787 punct .,induces
R2984 T3816 T3817 compound Cell,viability
R2985 T3817 T3819 nsubjpass viability,determined
R2986 T3818 T3819 auxpass was,determined
R2987 T3819 T3819 ROOT determined,determined
R2988 T3820 T3819 agent by,determined
R2989 T3821 T3822 compound propidium,iodide
R2990 T3822 T3820 pobj iodide,by
R2991 T3823 T3824 punct (,PI
R2992 T3824 T3822 appos PI,iodide
R2993 T3825 T3822 punct ),iodide
R2994 T3826 T3819 prep staining,determined
R2995 T3827 T3826 prep after,staining
R2996 T3828 T3827 pobj culture,after
R2997 T3829 T3826 prep with,staining
R2998 T3830 T3829 cc or,with
R2999 T3831 T3829 conj without,with
R3000 T3832 T3831 pobj BMP-6,without
R3001 T3833 T3826 prep for,staining
R3002 T3834 T3835 nummod 48,hours
R3003 T3835 T3833 pobj hours,for
R3004 T3836 T3819 punct .,determined
R3005 T3837 T3840 advmod Interestingly,showed
R3006 T3838 T3840 punct ",",showed
R3007 T3839 T3840 nsubj BMP-6,showed
R3008 T3840 T3861 ccomp showed,p
R3009 T3841 T3847 det a,increase
R3010 T3842 T3847 amod small,increase
R3011 T3843 T3842 punct ",",small
R3012 T3844 T3842 cc but,small
R3013 T3845 T3842 conj reproducible,small
R3014 T3846 T3842 conj mean,small
R3015 T3847 T3840 dobj increase,showed
R3016 T3848 T3847 prep of,increase
R3017 T3849 T3850 compound cell,death
R3018 T3850 T3848 pobj death,of
R3019 T3851 T3847 prep from,increase
R3020 T3852 T3854 quantmod 17,23
R3021 T3853 T3854 quantmod to,23
R3022 T3854 T3855 nummod 23,%
R3023 T3855 T3851 pobj %,from
R3024 T3856 T3859 punct (,5
R3025 T3857 T3859 advmod n,5
R3026 T3858 T3859 punct =,5
R3027 T3859 T3855 npadvmod 5,%
R3028 T3860 T3861 punct ;,p
R3029 T3861 T3861 ROOT p,p
R3030 T3862 T3861 dobj ≤,p
R3031 T3863 T3862 nummod "0,003",≤
R3032 T3864 T3862 punct ),≤
R3033 T3865 T3861 prep in,p
R3034 T3866 T3867 npadvmod anti-IgM,stimulated
R3035 T3867 T3861 conj stimulated,p
R3036 T3868 T3872 compound CD27,cells
R3037 T3869 T3871 compound +,B
R3038 T3870 T3871 compound memory,B
R3039 T3871 T3872 compound B,cells
R3040 T3872 T3867 dobj cells,stimulated
R3041 T3873 T3861 punct .,p
R3042 T3874 T3878 advmod Furthermore,showed
R3043 T3875 T3878 punct ",",showed
R3044 T3876 T3877 compound Ramos,cells
R3045 T3877 T3878 nsubj cells,showed
R3046 T3878 T3878 ROOT showed,showed
R3047 T3879 T3881 det a,increase
R3048 T3880 T3881 amod mean,increase
R3049 T3881 T3878 dobj increase,showed
R3050 T3882 T3881 prep in,increase
R3051 T3883 T3884 compound cell,death
R3052 T3884 T3882 pobj death,in
R3053 T3885 T3881 prep from,increase
R3054 T3886 T3885 pobj 20,from
R3055 T3887 T3878 prep to,showed
R3056 T3888 T3889 nummod 50,%
R3057 T3889 T3887 pobj %,to
R3058 T3890 T3896 punct (,<
R3059 T3891 T3895 dep n,p
R3060 T3892 T3893 punct =,3
R3061 T3893 T3891 prep 3,n
R3062 T3894 T3895 punct ",",p
R3063 T3895 T3896 compound p,<
R3064 T3896 T3878 advcl <,showed
R3065 T3897 T3896 appos "0,001",<
R3066 T3898 T3899 punct ",",figure
R3067 T3899 T3896 appos figure,<
R3068 T3900 T3899 nummod 3,figure
R3069 T3901 T3896 punct ),<
R3070 T3902 T3878 prep after,showed
R3071 T3903 T3904 compound BMP-6,treatment
R3072 T3904 T3902 pobj treatment,after
R3073 T3905 T3878 punct .,showed
R3074 T3906 T3935 prep In,was
R3075 T3907 T3906 pobj contrast,In
R3076 T3908 T3935 punct ",",was
R3077 T3909 T3910 compound cell,death
R3078 T3910 T3935 nsubj death,was
R3079 T3911 T3910 prep of,death
R3080 T3912 T3915 amod total,cells
R3081 T3913 T3915 compound CD19,cells
R3082 T3914 T3915 compound +,cells
R3083 T3915 T3911 pobj cells,of
R3084 T3916 T3919 punct (,6
R3085 T3917 T3919 advmod n,6
R3086 T3918 T3919 punct =,6
R3087 T3919 T3910 npadvmod 6,death
R3088 T3920 T3921 punct ;,p
R3089 T3921 T3935 ccomp p,was
R3090 T3922 T3921 dobj ≤,p
R3091 T3923 T3922 nummod "0,32",≤
R3092 T3924 T3921 punct ;,p
R3093 T3925 T3932 nmod data,naïve
R3094 T3926 T3927 neg not,shown
R3095 T3927 T3925 acl shown,data
R3096 T3928 T3925 punct ),data
R3097 T3929 T3925 cc or,data
R3098 T3930 T3925 conj CD27-IgG,data
R3099 T3931 T3932 punct -,naïve
R3100 T3932 T3934 compound naïve,cells
R3101 T3933 T3934 compound B,cells
R3102 T3934 T3935 nsubj cells,was
R3103 T3935 T3935 ROOT was,was
R3104 T3936 T3935 neg not,was
R3105 T3937 T3938 advmod significantly,affected
R3106 T3938 T3935 acomp affected,was
R3107 T3939 T3945 punct (,≤
R3108 T3940 T3944 dep n,p
R3109 T3941 T3942 punct =,5
R3110 T3942 T3940 nummod 5,n
R3111 T3943 T3944 punct ;,p
R3112 T3944 T3945 compound p,≤
R3113 T3945 T3938 parataxis ≤,affected
R3114 T3946 T3945 appos "0,65",≤
R3115 T3947 T3945 punct ",",≤
R3116 T3948 T3935 conj figure,was
R3117 T3949 T3948 nummod 2,figure
R3118 T3950 T3948 punct ),figure
R3119 T3951 T3935 punct .,was
R3296 T4266 T4267 compound Human,B
R3297 T4267 T4268 compound B,cells
R3298 T4268 T4269 nsubj cells,express
R3299 T4269 T4269 ROOT express,express
R3300 T4270 T4271 compound BMP-6,receptors
R3301 T4271 T4269 dobj receptors,express
R3302 T4272 T4273 amod Detailed,knowledge
R3303 T4273 T4283 nsubj knowledge,is
R3304 T4274 T4273 acl regarding,knowledge
R3305 T4275 T4274 pobj expression,regarding
R3306 T4276 T4275 prep of,expression
R3307 T4277 T4279 amod different,receptors
R3308 T4278 T4279 compound BMP,receptors
R3309 T4279 T4276 pobj receptors,of
R3310 T4280 T4279 prep in,receptors
R3311 T4281 T4282 compound B,cells
R3312 T4282 T4280 pobj cells,in
R3313 T4283 T4283 ROOT is,is
R3314 T4284 T4283 advmod currently,is
R3315 T4285 T4283 neg not,is
R3316 T4286 T4283 acomp available,is
R3317 T4287 T4283 punct .,is
R3318 T4288 T4290 aux To,elucidate
R3319 T4289 T4290 advmod further,elucidate
R3320 T4290 T4301 advcl elucidate,performed
R3321 T4291 T4292 det the,role
R3322 T4292 T4290 dobj role,elucidate
R3323 T4293 T4292 prep of,role
R3324 T4294 T4293 pobj BMPs,of
R3325 T4295 T4294 prep in,BMPs
R3326 T4296 T4298 amod human,cells
R3327 T4297 T4298 compound B,cells
R3328 T4298 T4295 pobj cells,in
R3329 T4299 T4301 punct ",",performed
R3330 T4300 T4301 nsubj we,performed
R3331 T4301 T4301 ROOT performed,performed
R3332 T4302 T4304 amod western,analysis
R3333 T4303 T4304 compound blot,analysis
R3334 T4304 T4301 dobj analysis,performed
R3335 T4305 T4301 prep for,performed
R3336 T4306 T4305 pobj type,for
R3337 T4307 T4306 dobj I,type
R3338 T4308 T4307 cc and,I
R3339 T4309 T4312 compound type,receptors
R3340 T4310 T4312 compound II,receptors
R3341 T4311 T4312 compound BMP,receptors
R3342 T4312 T4307 conj receptors,I
R3343 T4313 T4301 punct .,performed
R3344 T4314 T4315 det This,analysis
R3345 T4315 T4316 nsubj analysis,revealed
R3346 T4316 T4316 ROOT revealed,revealed
R3347 T4317 T4316 prep that,revealed
R3348 T4318 T4319 det the,type
R3349 T4319 T4317 dative type,that
R3350 T4320 T4321 nsubj I,receptors
R3351 T4321 T4319 relcl receptors,type
R3352 T4322 T4321 dobj Act-RIA,receptors
R3353 T4323 T4322 punct ",",Act-RIA
R3354 T4324 T4322 conj BMP-RIB,Act-RIA
R3355 T4325 T4324 cc and,BMP-RIB
R3356 T4326 T4329 det the,receptors
R3357 T4327 T4329 compound type,receptors
R3358 T4328 T4329 compound II,receptors
R3359 T4329 T4334 nsubjpass receptors,expressed
R3360 T4330 T4329 appos BMP-RII,receptors
R3361 T4331 T4330 cc and,BMP-RII
R3362 T4332 T4330 conj Act-RIIb,BMP-RII
R3363 T4333 T4334 auxpass are,expressed
R3364 T4334 T4321 ccomp expressed,receptors
R3365 T4335 T4334 prep on,expressed
R3366 T4336 T4335 pcomp resting,on
R3367 T4337 T4338 amod human,B-cells
R3368 T4338 T4336 dobj B-cells,resting
R3369 T4339 T4340 punct (,Figure
R3370 T4340 T4338 parataxis Figure,B-cells
R3371 T4341 T4340 nummod 4,Figure
R3372 T4342 T4340 punct ),Figure
R3373 T4343 T4334 punct .,expressed
R3374 T4344 T4345 compound Ramos,cells
R3375 T4345 T4346 nsubj cells,expressed
R3376 T4346 T4346 ROOT expressed,expressed
R3377 T4347 T4348 det the,type
R3378 T4348 T4346 dobj type,expressed
R3379 T4349 T4350 nsubj I,receptors
R3380 T4350 T4348 relcl receptors,type
R3381 T4351 T4350 dobj Act-RIA,receptors
R3382 T4352 T4351 punct ",",Act-RIA
R3383 T4353 T4354 advmod weakly,BMP-RIB
R3384 T4354 T4351 conj BMP-RIB,Act-RIA
R3385 T4355 T4354 cc and,BMP-RIB
R3386 T4356 T4360 det the,BMP-RII
R3387 T4357 T4360 compound type,BMP-RII
R3388 T4358 T4360 compound II,BMP-RII
R3389 T4359 T4360 compound receptor,BMP-RII
R3390 T4360 T4354 conj BMP-RII,BMP-RIB
R3391 T4361 T4360 punct ",",BMP-RII
R3392 T4362 T4360 cc but,BMP-RII
R3393 T4363 T4364 advmod more,weakly
R3394 T4364 T4360 conj weakly,BMP-RII
R3395 T4365 T4364 prep than,weakly
R3396 T4366 T4368 amod normal,cells
R3397 T4367 T4368 compound B,cells
R3398 T4368 T4365 pobj cells,than
R3399 T4369 T4370 punct (,Figure
R3400 T4370 T4368 appos Figure,cells
R3401 T4371 T4370 nummod 4,Figure
R3402 T4372 T4370 punct ),Figure
R3403 T4373 T4350 punct .,receptors
R3404 T4374 T4375 nummod HL60,cells
R3405 T4375 T4377 nsubjpass cells,used
R3406 T4376 T4377 auxpass were,used
R3407 T4377 T4377 ROOT used,used
R3408 T4378 T4377 prep for,used
R3409 T4379 T4378 pobj comparison,for
R3410 T4380 T4377 cc and,used
R3411 T4381 T4382 advmod weakly,expressed
R3412 T4382 T4377 conj expressed,used
R3413 T4383 T4382 dobj Act-RIA,expressed
R3414 T4384 T4383 cc and,Act-RIA
R3415 T4385 T4383 conj BMP-RII,Act-RIA
R3416 T4386 T4377 punct .,used
R3417 T4387 T4392 advcl Taken,show
R3418 T4388 T4387 advmod together,Taken
R3419 T4389 T4392 punct ",",show
R3420 T4390 T4391 det these,data
R3421 T4391 T4392 nsubj data,show
R3422 T4392 T4392 ROOT show,show
R3423 T4393 T4401 mark that,express
R3424 T4394 T4397 amod normal,cells
R3425 T4395 T4397 amod human,cells
R3426 T4396 T4397 compound B,cells
R3427 T4397 T4401 nsubj cells,express
R3428 T4398 T4397 cc and,cells
R3429 T4399 T4400 compound Ramos,cells
R3430 T4400 T4397 conj cells,cells
R3431 T4401 T4392 ccomp express,show
R3432 T4402 T4403 det a,set
R3433 T4403 T4401 dobj set,express
R3434 T4404 T4403 prep of,set
R3435 T4405 T4406 compound BMP,receptors
R3436 T4406 T4404 pobj receptors,of
R3437 T4407 T4403 punct ",",set
R3438 T4408 T4409 advmod previously,shown
R3439 T4409 T4403 acl shown,set
R3440 T4410 T4411 aux to,bind
R3441 T4411 T4409 xcomp bind,shown
R3442 T4412 T4413 compound BMP-6,[
R3443 T4413 T4411 dobj [,bind
R3444 T4414 T4415 nummod 16,]
R3445 T4415 T4413 appos ],[
R3773 T4892 T4893 nsubj BMP-6,induces
R3774 T4893 T4893 ROOT induces,induces
R3775 T4894 T4893 dobj phosphorylation,induces
R3776 T4895 T4894 prep of,phosphorylation
R3777 T4896 T4895 pobj Smad1/5/8,of
R3778 T4897 T4894 prep Upon,phosphorylation
R3779 T4898 T4899 compound ligand,binding
R3780 T4899 T4897 pobj binding,Upon
R3781 T4900 T4905 punct ",",transphosphorylates
R3782 T4901 T4905 det the,transphosphorylates
R3783 T4902 T4905 nmod type,transphosphorylates
R3784 T4903 T4905 compound II,transphosphorylates
R3785 T4904 T4905 compound receptor,transphosphorylates
R3786 T4905 T4893 conj transphosphorylates,induces
R3787 T4906 T4905 cc and,transphosphorylates
R3788 T4907 T4905 conj activates,transphosphorylates
R3789 T4908 T4909 det the,type
R3790 T4909 T4907 dobj type,activates
R3791 T4910 T4911 nsubj I,receptor
R3792 T4911 T4909 relcl receptor,type
R3793 T4912 T4893 punct .,induces
R3794 T4913 T4915 compound Type,receptors
R3795 T4914 T4915 compound I,receptors
R3796 T4915 T4917 nsubj receptors,signal
R3797 T4916 T4917 aux can,signal
R3798 T4917 T4917 ROOT signal,signal
R3799 T4918 T4917 prep via,signal
R3800 T4919 T4920 amod several,pathways
R3801 T4920 T4918 pobj pathways,via
R3802 T4921 T4917 punct .,signal
R3803 T4922 T4923 nsubj We,examined
R3804 T4923 T4923 ROOT examined,examined
R3805 T4924 T4925 det the,effect
R3806 T4925 T4923 dobj effect,examined
R3807 T4926 T4925 prep of,effect
R3808 T4927 T4926 pobj BMP-6,of
R3809 T4928 T4925 prep on,effect
R3810 T4929 T4930 compound Smad,phosphorylation
R3811 T4930 T4928 pobj phosphorylation,on
R3812 T4931 T4923 punct ",",examined
R3813 T4932 T4938 mark as,considered
R3814 T4933 T4934 det the,activation
R3815 T4934 T4938 nsubjpass activation,considered
R3816 T4935 T4934 prep of,activation
R3817 T4936 T4935 pobj Smad,of
R3818 T4937 T4938 auxpass is,considered
R3819 T4938 T4923 advcl considered,examined
R3820 T4939 T4940 aux to,be
R3821 T4940 T4938 xcomp be,considered
R3822 T4941 T4944 det a,pathway
R3823 T4942 T4944 amod major,pathway
R3824 T4943 T4944 amod signalling,pathway
R3825 T4944 T4940 attr pathway,be
R3826 T4945 T4944 prep for,pathway
R3827 T4946 T4945 pobj BMPs,for
R3828 T4947 T4944 appos [,pathway
R3829 T4948 T4949 nummod 17,]
R3830 T4949 T4947 appos ],[
R3831 T4950 T4923 punct .,examined
R3832 T4951 T4952 compound B,cells
R3833 T4952 T4954 nsubjpass cells,cultured
R3834 T4953 T4954 auxpass were,cultured
R3835 T4954 T4954 ROOT cultured,cultured
R3836 T4955 T4954 prep in,cultured
R3837 T4956 T4957 amod serum-free,media
R3838 T4957 T4955 pobj media,in
R3839 T4958 T4954 prep over,cultured
R3840 T4959 T4958 pobj night,over
R3841 T4960 T4954 cc and,cultured
R3842 T4961 T4962 advmod then,treated
R3843 T4962 T4954 conj treated,cultured
R3844 T4963 T4962 prep with,treated
R3845 T4964 T4963 pobj BMP-6,with
R3846 T4965 T4962 prep for,treated
R3847 T4966 T4968 amod various,points
R3848 T4967 T4968 compound time,points
R3849 T4968 T4965 pobj points,for
R3850 T4969 T4954 punct .,cultured
R3851 T4970 T4972 amod Total,lysates
R3852 T4971 T4972 compound protein,lysates
R3853 T4972 T4973 nsubj lysates,were
R3854 T4973 T4973 ROOT were,were
R3855 T4974 T4973 acomp prepared,were
R3856 T4975 T4974 punct ",",prepared
R3857 T4976 T4973 cc and,were
R3858 T4977 T4978 det the,amounts
R3859 T4978 T4986 nsubjpass amounts,determined
R3860 T4979 T4978 prep of,amounts
R3861 T4980 T4982 det the,forms
R3862 T4981 T4982 amod phosphorylated,forms
R3863 T4982 T4979 pobj forms,of
R3864 T4983 T4982 prep of,forms
R3865 T4984 T4983 pobj Smad1/5/8,of
R3866 T4985 T4986 auxpass were,determined
R3867 T4986 T4973 conj determined,were
R3868 T4987 T4986 agent by,determined
R3869 T4988 T4990 amod western,analysis
R3870 T4989 T4990 compound blot,analysis
R3871 T4990 T4987 pobj analysis,by
R3872 T4991 T4986 punct .,determined
R3873 T4992 T4999 advmod Interestingly,induced
R3874 T4993 T4999 punct ",",induced
R3875 T4994 T4999 nsubj treatment,induced
R3876 T4995 T4994 prep with,treatment
R3877 T4996 T4998 nummod 500,BMP-6
R3878 T4997 T4998 amod ng/ml,BMP-6
R3879 T4998 T4995 pobj BMP-6,with
R3880 T4999 T4999 ROOT induced,induced
R3881 T5000 T4999 dobj phosphorylation,induced
R3882 T5001 T5000 prep of,phosphorylation
R3883 T5002 T5001 pobj Smad,of
R3884 T5003 T4999 punct .,induced
R3885 T5004 T5005 det The,BMP-6
R3886 T5005 T5006 nsubj BMP-6,induced
R3887 T5006 T5006 ROOT induced,induced
R3888 T5007 T5008 nsubj phosphorylation,was
R3889 T5008 T5006 ccomp was,induced
R3890 T5009 T5008 acomp high,was
R3891 T5010 T5008 prep at,was
R3892 T5011 T5014 det the,point
R3893 T5012 T5014 amod earliest,point
R3894 T5013 T5014 compound time,point
R3895 T5014 T5010 pobj point,at
R3896 T5015 T5014 acl tested,point
R3897 T5016 T5015 punct (,tested
R3898 T5017 T5018 nummod 15,minutes
R3899 T5018 T5015 npadvmod minutes,tested
R3900 T5019 T5015 punct ),tested
R3901 T5020 T5008 punct ",",was
R3902 T5021 T5008 cc and,was
R3903 T5022 T5008 conj remained,was
R3904 T5023 T5022 acomp high,remained
R3905 T5024 T5022 prep for,remained
R3906 T5025 T5026 advmod at,least
R3907 T5026 T5027 advmod least,48
R3908 T5027 T5028 nummod 48,hours
R3909 T5028 T5024 pobj hours,for
R3910 T5029 T5030 punct (,Figure
R3911 T5030 T5028 appos Figure,hours
R3912 T5031 T5030 nummod 5,Figure
R3913 T5032 T5030 punct ),Figure
R3914 T5033 T5006 punct .,induced
R3915 T5034 T5036 det A,phosphorylation
R3916 T5035 T5036 amod similar,phosphorylation
R3917 T5036 T5038 nsubjpass phosphorylation,observed
R3918 T5037 T5038 auxpass was,observed
R3919 T5038 T5038 ROOT observed,observed
R3920 T5039 T5038 prep in,observed
R3921 T5040 T5041 compound Ramos,cells
R3922 T5041 T5039 pobj cells,in
R3923 T5042 T5038 punct ",",observed
R3924 T5043 T5038 cc but,observed
R3925 T5044 T5045 neg not,in
R3926 T5045 T5038 conj in,observed
R3927 T5046 T5047 nummod HL60,cells
R3928 T5047 T5045 pobj cells,in
R3929 T5048 T5049 punct (,Figure
R3930 T5049 T5047 appos Figure,cells
R3931 T5050 T5049 nummod 6,Figure
R3932 T5051 T5049 punct ),Figure
R3933 T5052 T5038 punct .,observed
R3934 T5053 T5057 advmod Furthermore,tested
R3935 T5054 T5057 punct ",",tested
R3936 T5055 T5057 nsubj we,tested
R3937 T5056 T5057 advmod also,tested
R3938 T5057 T5057 ROOT tested,tested
R3939 T5058 T5068 mark whether,triggered
R3940 T5059 T5063 amod other,pathways
R3941 T5060 T5063 amod known,pathways
R3942 T5061 T5063 amod downstream,pathways
R3943 T5062 T5063 amod signalling,pathways
R3944 T5063 T5068 nsubjpass pathways,triggered
R3945 T5064 T5063 prep of,pathways
R3946 T5065 T5064 pobj BMP-6,of
R3947 T5066 T5068 aux could,triggered
R3948 T5067 T5068 auxpass be,triggered
R3949 T5068 T5057 advcl triggered,tested
R3950 T5069 T5068 agent by,triggered
R3951 T5070 T5069 pobj BMP-6,by
R3952 T5071 T5068 prep in,triggered
R3953 T5072 T5074 amod human,cells
R3954 T5073 T5074 compound B,cells
R3955 T5074 T5071 pobj cells,in
R3956 T5075 T5057 punct .,tested
R3957 T5076 T5081 advmod However,observe
R3958 T5077 T5081 punct ",",observe
R3959 T5078 T5081 nsubj we,observe
R3960 T5079 T5081 aux did,observe
R3961 T5080 T5081 neg not,observe
R3962 T5081 T5081 ROOT observe,observe
R3963 T5082 T5084 det any,changes
R3964 T5083 T5084 amod significant,changes
R3965 T5084 T5081 dobj changes,observe
R3966 T5085 T5084 prep in,changes
R3967 T5086 T5087 det the,level
R3968 T5087 T5085 pobj level,in
R3969 T5088 T5087 prep of,level
R3970 T5089 T5101 dobj phospho-STAT3,shown
R3971 T5090 T5089 cc or,phospho-STAT3
R3972 T5091 T5089 conj phospho-p38,phospho-STAT3
R3973 T5092 T5091 prep upon,phospho-p38
R3974 T5093 T5094 amod BMP-6,treatment
R3975 T5094 T5092 pobj treatment,upon
R3976 T5095 T5094 prep of,treatment
R3977 T5096 T5097 compound B,cells
R3978 T5097 T5095 pobj cells,of
R3979 T5098 T5101 punct (,shown
R3980 T5099 T5101 nsubjpass data,shown
R3981 T5100 T5101 neg not,shown
R3982 T5101 T5081 advcl shown,observe
R3983 T5102 T5101 punct ),shown
R3984 T5103 T5081 punct .,observe
R4569 T5850 T5851 nsubj BMP-6,induces
R4570 T5851 T5851 ROOT induces,induces
R4571 T5852 T5851 dobj upregulation,induces
R4572 T5853 T5852 prep of,upregulation
R4573 T5854 T5855 compound Id1,Next
R4574 T5855 T5853 pobj Next,of
R4575 T5856 T5858 punct ",",wanted
R4576 T5857 T5858 nsubj we,wanted
R4577 T5858 T5851 ccomp wanted,induces
R4578 T5859 T5860 aux to,explore
R4579 T5860 T5858 xcomp explore,wanted
R4580 T5861 T5864 mark whether,induced
R4581 T5862 T5863 det the,BMP-6
R4582 T5863 T5864 nsubj BMP-6,induced
R4583 T5864 T5858 advcl induced,wanted
R4584 T5865 T5864 dobj phosphorylation,induced
R4585 T5866 T5865 prep of,phosphorylation
R4586 T5867 T5868 compound Smad,1/5/8
R4587 T5868 T5866 pobj 1/5/8,of
R4588 T5869 T5871 advmod also,induce
R4589 T5870 T5871 aux could,induce
R4590 T5871 T5858 conj induce,wanted
R4592 T5873 T5871 dobj changes,induce
R4593 T5874 T5873 prep of,changes
R4594 T5875 T5876 compound target,genes
R4595 T5876 T5874 pobj genes,of
R4596 T5877 T5851 punct .,induces
R4597 T5878 T5892 prep In,considered
R4598 T5879 T5880 det this,regard
R4599 T5880 T5878 pobj regard,In
R4600 T5881 T5892 punct ",",considered
R4601 T5882 T5883 det the,inhibitors
R4602 T5883 T5892 nsubjpass inhibitors,considered
R4603 T5884 T5883 prep of,inhibitors
R4604 T5885 T5884 pobj DNA,of
R4605 T5886 T5887 amod binding,proteins
R4606 T5887 T5883 conj proteins,inhibitors
R4607 T5888 T5889 punct (,Ids
R4608 T5889 T5887 appos Ids,proteins
R4609 T5890 T5887 punct ),proteins
R4610 T5891 T5892 auxpass are,considered
R4611 T5892 T5892 ROOT considered,considered
R4612 T5893 T5894 aux to,be
R4613 T5894 T5892 xcomp be,considered
R4614 T5895 T5894 attr some,be
R4615 T5896 T5895 prep of,some
R4616 T5897 T5900 det the,genes
R4617 T5898 T5900 amod major,genes
R4618 T5899 T5900 compound target,genes
R4619 T5900 T5896 pobj genes,of
R4620 T5901 T5900 prep for,genes
R4621 T5902 T5903 compound Smad-signalling,[
R4622 T5903 T5901 pobj [,for
R4623 T5904 T5905 nummod 17,]
R4624 T5905 T5894 npadvmod ],be
R4625 T5906 T5892 punct .,considered
R4626 T5907 T5912 advmod Thus,pre-incubated
R4627 T5908 T5912 punct ",",pre-incubated
R4628 T5909 T5910 compound B,cells
R4629 T5910 T5912 nsubjpass cells,pre-incubated
R4630 T5911 T5912 auxpass were,pre-incubated
R4631 T5912 T5912 ROOT pre-incubated,pre-incubated
R4632 T5913 T5912 prep over,pre-incubated
R4633 T5914 T5913 pobj night,over
R4634 T5915 T5912 prep in,pre-incubated
R4635 T5916 T5915 pobj X-VIVO,in
R4636 T5917 T5916 nummod 15,X-VIVO
R4637 T5918 T5912 punct ",",pre-incubated
R4638 T5919 T5912 cc and,pre-incubated
R4639 T5920 T5921 advmod then,cultured
R4640 T5921 T5912 conj cultured,pre-incubated
R4641 T5922 T5921 prep in,cultured
R4642 T5923 T5922 pobj medium,in
R4643 T5924 T5921 advmod alone,cultured
R4644 T5925 T5921 cc or,cultured
R4645 T5926 T5921 conj in,cultured
R4646 T5927 T5928 det the,presence
R4647 T5928 T5926 pobj presence,in
R4648 T5929 T5928 prep of,presence
R4649 T5930 T5929 pobj BMP-6,of
R4650 T5931 T5921 prep for,cultured
R4651 T5932 T5934 amod various,points
R4652 T5933 T5934 compound time,points
R4653 T5934 T5931 pobj points,for
R4654 T5935 T5921 prep before,cultured
R4655 T5936 T5935 pobj preparation,before
R4656 T5937 T5936 prep of,preparation
R4657 T5938 T5939 amod total,RNA
R4658 T5939 T5937 pobj RNA,of
R4659 T5940 T5912 punct .,pre-incubated
R4660 T5941 T5942 det The,amount
R4661 T5942 T5948 nsubjpass amount,quantified
R4662 T5943 T5942 prep of,amount
R4663 T5944 T5943 pobj Id1,of
R4664 T5945 T5946 compound Id4,mRNA
R4665 T5946 T5942 appos mRNA,amount
R4666 T5947 T5948 auxpass was,quantified
R4667 T5948 T5948 ROOT quantified,quantified
R4668 T5949 T5948 agent by,quantified
R4669 T5950 T5951 amod real-time,RT-PCR
R4670 T5951 T5949 pobj RT-PCR,by
R4671 T5952 T5948 punct .,quantified
R4672 T5953 T5956 advmod Interestingly,observed
R4673 T5954 T5956 punct ",",observed
R4674 T5955 T5956 nsubj we,observed
R4675 T5956 T5956 ROOT observed,observed
R4676 T5957 T5960 det a,upregulation
R4677 T5958 T5960 amod specific,upregulation
R4678 T5959 T5960 amod four-fold,upregulation
R4679 T5960 T5956 dobj upregulation,observed
R4680 T5961 T5960 prep of,upregulation
R4681 T5962 T5963 compound Id1,mRNA
R4682 T5963 T5961 pobj mRNA,of
R4683 T5964 T5963 prep in,mRNA
R4684 T5965 T5966 compound BMP-6-treated,B
R4685 T5966 T5967 compound B,cells
R4686 T5967 T5964 pobj cells,in
R4687 T5968 T5969 punct (,Figure
R4688 T5969 T5963 appos Figure,mRNA
R4689 T5970 T5969 nummod 7,Figure
R4690 T5971 T5969 punct ),Figure
R4691 T5972 T5956 punct .,observed
R4692 T5973 T5974 det The,up-regulation
R4693 T5974 T5978 nsubj up-regulation,was
R4694 T5975 T5974 prep of,up-regulation
R4695 T5976 T5977 compound Id1,mRNA
R4696 T5977 T5975 pobj mRNA,of
R4697 T5978 T5978 ROOT was,was
R4698 T5979 T5978 acomp characteristic,was
R4699 T5980 T5979 prep of,characteristic
R4700 T5981 T5984 det an,gene
R4701 T5982 T5984 amod early,gene
R4702 T5983 T5984 compound inducible,gene
R4703 T5984 T5980 pobj gene,of
R4704 T5985 T5984 punct ",",gene
R4705 T5986 T5979 prep with,characteristic
R4706 T5987 T5988 amod maximal,upregulation
R4707 T5988 T5986 pobj upregulation,with
R4708 T5989 T5990 nummod two,hours
R4709 T5990 T5991 npadvmod hours,after
R4710 T5991 T5978 prep after,was
R4711 T5992 T5993 det the,addition
R4712 T5993 T5991 pobj addition,after
R4713 T5994 T5993 prep of,addition
R4714 T5995 T5994 pobj BMP-6,of
R4715 T5996 T5978 cc and,was
R4716 T5997 T5978 conj returned,was
R4717 T5998 T5997 prep to,returned
R4718 T5999 T5998 pobj baseline,to
R4719 T6000 T5997 prep after,returned
R4720 T6001 T6002 nummod 24,hours
R4721 T6002 T6000 pobj hours,after
R4722 T6003 T5978 punct .,was
R4723 T6004 T6011 prep In,observed
R4724 T6005 T6004 pobj contrast,In
R4725 T6006 T6011 punct ",",observed
R4726 T6007 T6009 det no,changes
R4727 T6008 T6009 amod significant,changes
R4728 T6009 T6011 nsubjpass changes,observed
R4729 T6010 T6011 auxpass were,observed
R4730 T6011 T6011 ROOT observed,observed
R4731 T6012 T6011 prep for,observed
R4732 T6013 T6012 pobj Id2,for
R4733 T6014 T6013 cc and,Id2
R4734 T6015 T6016 compound Id3,mRNA
R4735 T6016 T6013 conj mRNA,Id2
R4736 T6017 T6011 punct ",",observed
R4737 T6018 T6020 mark whereas,were
R4738 T6019 T6020 nsubj Id4-transcripts,were
R4739 T6020 T6011 advcl were,observed
R4740 T6021 T6020 neg not,were
R4741 T6022 T6020 acomp detectable,were
R4742 T6023 T6024 punct (,Figure
R4743 T6024 T6020 prep Figure,were
R4744 T6025 T6024 nummod 7,Figure
R4745 T6026 T6024 punct ",",Figure
R4746 T6027 T6024 appos data,Figure
R4747 T6028 T6029 neg not,shown
R4748 T6029 T6027 acl shown,data
R4749 T6030 T6024 punct ),Figure
R4750 T6031 T6011 punct .,observed
R4751 T6032 T6034 amod Western,analysis
R4752 T6033 T6034 compound blot,analysis
R4753 T6034 T6035 nsubj analysis,revealed
R4754 T6035 T6035 ROOT revealed,revealed
R4755 T6036 T6045 mark that,correlated
R4756 T6037 T6039 det the,upregulation
R4757 T6038 T6039 amod BMP-6-induced,upregulation
R4758 T6039 T6045 nsubjpass upregulation,correlated
R4759 T6040 T6039 prep of,upregulation
R4760 T6041 T6042 compound Id1,mRNA
R4761 T6042 T6040 pobj mRNA,of
R4762 T6043 T6045 advmod also,correlated
R4763 T6044 T6045 auxpass was,correlated
R4764 T6045 T6035 ccomp correlated,revealed
R4765 T6046 T6045 prep with,correlated
R4766 T6047 T6046 pobj upregulation,with
R4767 T6048 T6047 prep of,upregulation
R4768 T6049 T6050 amod Id1,protein
R4769 T6050 T6048 pobj protein,of
R4770 T6051 T6052 advmod as,well
R4771 T6052 T6045 advmod well,correlated
R4772 T6053 T6035 punct .,revealed
R4773 T6054 T6055 det The,increase
R4774 T6055 T6060 nsubj increase,was
R4775 T6056 T6055 prep in,increase
R4776 T6057 T6059 amod Id1,level
R4777 T6058 T6059 compound protein,level
R4778 T6059 T6056 pobj level,in
R4779 T6060 T6086 ccomp was,n
R4780 T6061 T6060 acomp detectable,was
R4781 T6062 T6060 prep after,was
R4782 T6063 T6064 nummod one,hour
R4783 T6064 T6062 pobj hour,after
R4784 T6065 T6060 cc and,was
R4785 T6066 T6060 conj increased,was
R4786 T6067 T6066 prep until,increased
R4787 T6068 T6069 nummod 24,hours
R4788 T6069 T6074 npadvmod hours,showing
R4789 T6070 T6074 prep after,showing
R4790 T6071 T6072 compound BMP-6,addition
R4791 T6072 T6070 pobj addition,after
R4792 T6073 T6074 punct ",",showing
R4793 T6074 T6066 advcl showing,increased
R4794 T6075 T6077 det a,upregulation
R4795 T6076 T6077 amod 16-fold,upregulation
R4796 T6077 T6074 dobj upregulation,showing
R4797 T6078 T6074 prep compared,showing
R4798 T6079 T6078 prep with,compared
R4799 T6080 T6084 nummod t0,0.020
R4800 T6081 T6083 punct (,≤
R4801 T6082 T6083 compound p,≤
R4802 T6083 T6084 nummod ≤,0.020
R4803 T6084 T6079 pobj 0.020,with
R4804 T6085 T6086 punct ",",n
R4805 T6086 T6086 ROOT n,n
R4806 T6087 T6088 punct =,4
R4807 T6088 T6086 nummod 4,n
R4808 T6089 T6088 punct ),4
R4809 T6090 T6091 punct (,Figure
R4810 T6091 T6086 appos Figure,n
R4811 T6092 T6091 nummod 8,Figure
R4812 T6093 T6092 cc and,8
R4813 T6094 T6092 conj 9,8
R4814 T6095 T6091 punct ),Figure
R4815 T6096 T6086 punct .,n
R4816 T6097 T6117 prep In,observed
R4817 T6098 T6097 pobj line,In
R4818 T6099 T6098 prep with,line
R4819 T6100 T6102 det the,data
R4820 T6101 T6102 compound mRNA,data
R4821 T6102 T6099 pobj data,with
R4822 T6103 T6117 punct ",",observed
R4823 T6104 T6106 det no,change
R4824 T6105 T6106 amod consistent,change
R4825 T6106 T6117 nsubjpass change,observed
R4826 T6107 T6106 prep in,change
R4827 T6108 T6109 det the,amounts
R4828 T6109 T6107 pobj amounts,in
R4829 T6110 T6109 prep of,amounts
R4830 T6111 T6114 amod Id2,protein
R4831 T6112 T6111 cc and,Id2
R4832 T6113 T6111 conj Id3,Id2
R4833 T6114 T6110 pobj protein,of
R4834 T6115 T6117 aux could,observed
R4835 T6116 T6117 auxpass be,observed
R4836 T6117 T6117 ROOT observed,observed
R4837 T6118 T6119 punct (,Figure
R4838 T6119 T6119 ROOT Figure,Figure
R4839 T6120 T6119 nummod 8,Figure
R4840 T6121 T6120 cc and,8
R4841 T6122 T6120 conj 9,8
R4842 T6123 T6119 punct ),Figure
R4843 T6124 T6117 punct .,observed
R4844 T6125 T6126 nsubj We,were
R4845 T6126 T6126 ROOT were,were
R4846 T6127 T6126 acomp able,were
R4847 T6128 T6129 aux to,block
R4848 T6129 T6127 xcomp block,able
R4849 T6130 T6133 det the,band
R4850 T6131 T6133 amod Id1,band
R4851 T6132 T6133 amod specific,band
R4852 T6133 T6129 dobj band,block
R4853 T6134 T6129 prep with,block
R4854 T6135 T6137 det a,peptide
R4855 T6136 T6137 amod blocking,peptide
R4856 T6137 T6134 pobj peptide,with
R4857 T6138 T6141 punct (,shown
R4858 T6139 T6141 nsubjpass data,shown
R4859 T6140 T6141 neg not,shown
R4860 T6141 T6137 relcl shown,peptide
R4861 T6142 T6141 punct ),shown
R4862 T6143 T6126 punct .,were
R4863 T6144 T6149 advcl Taken,suggest
R4864 T6145 T6144 advmod together,Taken
R4865 T6146 T6149 punct ",",suggest
R4866 T6147 T6148 det these,data
R4867 T6148 T6149 nsubj data,suggest
R4868 T6149 T6149 ROOT suggest,suggest
R4869 T6150 T6153 mark that,be
R4870 T6151 T6153 nsubj Id1,be
R4871 T6152 T6153 aux could,be
R4872 T6153 T6149 ccomp be,suggest
R4873 T6154 T6157 det a,gene
R4874 T6155 T6157 amod possible,gene
R4875 T6156 T6157 compound target,gene
R4876 T6157 T6153 attr gene,be
R4877 T6158 T6157 prep for,gene
R4878 T6159 T6158 pcomp mediating,for
R4879 T6160 T6161 det the,effects
R4880 T6161 T6159 dobj effects,mediating
R4881 T6162 T6161 prep of,effects
R4882 T6163 T6162 pobj BMP-6,of
R4883 T6164 T6161 prep in,effects
R4884 T6165 T6167 amod human,cells
R4885 T6166 T6167 compound B,cells
R4886 T6167 T6164 pobj cells,in
R4887 T6168 T6153 punct ",",be
R4888 T6169 T6174 mark whereas,seem
R4889 T6170 T6174 nsubj Id2,seem
R4890 T6171 T6170 cc and,Id2
R4891 T6172 T6170 conj Id3,Id2
R4892 T6173 T6174 neg not,seem
R4893 T6174 T6149 advcl seem,suggest
R4894 T6175 T6177 aux to,involved
R4895 T6176 T6177 auxpass be,involved
R4896 T6177 T6174 xcomp involved,seem
R4897 T6178 T6149 punct .,suggest
R5311 T6787 T6788 compound BMP-6,production
R5312 T6788 T6816 nsubj production,prompted
R5313 T6789 T6788 prep in,production
R5314 T6790 T6791 amod B,cells
R5315 T6791 T6789 pobj cells,in
R5316 T6792 T6793 det The,fact
R5317 T6793 T6816 nsubj fact,prompted
R5318 T6794 T6798 mark that,reported
R5319 T6795 T6798 nsubjpass BMP-6,reported
R5320 T6796 T6798 aux has,reported
R5321 T6797 T6798 auxpass been,reported
R5322 T6798 T6793 acl reported,fact
R5323 T6799 T6800 aux to,act
R5324 T6800 T6798 xcomp act,reported
R5325 T6801 T6800 prep as,act
R5326 T6802 T6804 det an,stimulator
R5327 T6803 T6804 compound autocrine,stimulator
R5328 T6804 T6801 pobj stimulator,as
R5329 T6805 T6804 prep in,stimulator
R5330 T6806 T6805 pobj chondrocytes,in
R5331 T6807 T6809 nmod [,]
R5332 T6808 T6809 nummod 18,]
R5333 T6809 T6816 nsubj ],prompted
R5334 T6810 T6809 cc and,]
R5335 T6811 T6812 compound ovarium,[
R5336 T6812 T6809 conj [,]
R5337 T6813 T6814 nummod 19,]
R5338 T6814 T6812 appos ],[
R5339 T6815 T6816 punct ",",prompted
R5340 T6816 T6816 ROOT prompted,prompted
R5341 T6817 T6816 dobj us,prompted
R5342 T6818 T6819 aux to,investigate
R5343 T6819 T6816 xcomp investigate,prompted
R5344 T6820 T6826 mark whether,produce
R5345 T6821 T6824 amod normal,cells
R5346 T6822 T6823 compound human,B
R5347 T6823 T6824 compound B,cells
R5348 T6824 T6826 nsubj cells,produce
R5349 T6825 T6826 aux could,produce
R5350 T6826 T6819 ccomp produce,investigate
R5351 T6827 T6826 dobj BMP-6,produce
R5352 T6828 T6826 prep upon,produce
R5353 T6829 T6828 pobj stimulation,upon
R5354 T6830 T6816 punct .,prompted
R5355 T6831 T6832 compound Ramos,cells
R5356 T6832 T6854 nsubj cells,served
R5357 T6833 T6832 punct ",",cells
R5358 T6834 T6837 nsubjpass which,described
R5359 T6835 T6837 aux have,described
R5360 T6836 T6837 auxpass been,described
R5361 T6837 T6832 relcl described,cells
R5362 T6838 T6839 aux to,express
R5363 T6839 T6837 xcomp express,described
R5364 T6840 T6841 compound BMP-6,mRNA
R5365 T6841 T6839 dobj mRNA,express
R5366 T6842 T6843 compound endogenously,[
R5367 T6843 T6841 appos [,mRNA
R5368 T6844 T6845 nummod 20,]
R5369 T6845 T6841 conj ],mRNA
R5370 T6846 T6845 punct ",",]
R5371 T6847 T6845 cc and,]
R5372 T6848 T6851 det the,line
R5373 T6849 T6850 compound T,cell
R5374 T6850 T6851 compound cell,line
R5375 T6851 T6852 compound line,Jurkat
R5376 T6852 T6845 conj Jurkat,]
R5377 T6853 T6832 punct ",",cells
R5378 T6854 T6854 ROOT served,served
R5379 T6855 T6854 prep as,served
R5380 T6856 T6859 amod positive,controls
R5381 T6857 T6856 cc and,positive
R5382 T6858 T6856 conj negative,positive
R5383 T6859 T6855 pobj controls,as
R5384 T6860 T6854 punct ",",served
R5385 T6861 T6854 advmod respectively,served
R5386 T6862 T6854 punct .,served
R5387 T6863 T6865 compound Endogenous,mRNA
R5388 T6864 T6865 compound BMP-6,mRNA
R5389 T6865 T6866 compound mRNA,levels
R5390 T6866 T6872 nsubjpass levels,quantified
R5391 T6867 T6866 prep in,levels
R5392 T6868 T6870 amod normal,cells
R5393 T6869 T6870 compound B,cells
R5394 T6870 T6867 pobj cells,in
R5395 T6871 T6872 auxpass were,quantified
R5396 T6872 T6872 ROOT quantified,quantified
R5397 T6873 T6872 agent by,quantified
R5398 T6874 T6875 amod real-time,RT-PCR
R5399 T6875 T6873 pobj RT-PCR,by
R5400 T6876 T6872 prep after,quantified
R5401 T6877 T6876 pobj stimulation,after
R5402 T6878 T6877 prep with,stimulation
R5403 T6879 T6878 pobj anti-IgM,with
R5404 T6880 T6872 prep for,quantified
R5405 T6881 T6883 amod different,points
R5406 T6882 T6883 compound time,points
R5407 T6883 T6880 pobj points,for
R5408 T6884 T6872 punct .,quantified
R5409 T6885 T6892 advmod Interestingly,was
R5410 T6886 T6892 punct ",",was
R5411 T6887 T6888 det the,up-regulation
R5412 T6888 T6892 nsubj up-regulation,was
R5413 T6889 T6888 prep of,up-regulation
R5414 T6890 T6891 compound BMP-6,mRNA
R5415 T6891 T6889 pobj mRNA,of
R5416 T6892 T6892 ROOT was,was
R5417 T6893 T6892 acomp characteristic,was
R5418 T6894 T6893 prep of,characteristic
R5419 T6895 T6899 det an,gene
R5420 T6896 T6899 amod early-to,gene
R5421 T6897 T6899 amod intermediate,gene
R5422 T6898 T6899 amod inducible,gene
R5423 T6899 T6894 pobj gene,of
R5424 T6900 T6893 prep with,characteristic
R5425 T6901 T6902 amod maximal,upregulation
R5426 T6902 T6900 pobj upregulation,with
R5427 T6903 T6904 nummod four,hours
R5428 T6904 T6905 npadvmod hours,after
R5429 T6905 T6892 prep after,was
R5430 T6906 T6907 det the,addition
R5431 T6907 T6905 pobj addition,after
R5432 T6908 T6907 prep of,addition
R5433 T6909 T6908 pobj anti-IgM,of
R5434 T6910 T6892 punct .,was
R5435 T6911 T6912 det The,level
R5436 T6912 T6916 nsubj level,was
R5437 T6913 T6912 prep of,level
R5438 T6914 T6915 compound BMP-6,mRNA
R5439 T6915 T6913 pobj mRNA,of
R5440 T6916 T6916 ROOT was,was
R5441 T6917 T6916 advmod back,was
R5442 T6918 T6917 prep to,back
R5443 T6919 T6918 pobj baseline,to
R5444 T6920 T6916 prep after,was
R5445 T6921 T6922 nummod 24,hours
R5446 T6922 T6920 pobj hours,after
R5447 T6923 T6922 prep upon,hours
R5448 T6924 T6923 pobj stimulation,upon
R5449 T6925 T6926 punct (,Figure
R5450 T6926 T6922 appos Figure,hours
R5451 T6927 T6926 nummod 10,Figure
R5452 T6928 T6916 punct ),was
R5453 T6929 T6916 punct .,was
R5454 T6930 T6937 advmod Furthermore,induced
R5455 T6931 T6937 punct ",",induced
R5456 T6932 T6933 preconj both,FCS
R5457 T6933 T6937 nsubj FCS,induced
R5458 T6934 T6933 cc and,FCS
R5459 T6935 T6937 nsubj human,induced
R5460 T6936 T6937 nsubj AB-serum,induced
R5461 T6937 T6937 ROOT induced,induced
R5462 T6938 T6939 amod significant,upregulation
R5463 T6939 T6937 dobj upregulation,induced
R5464 T6940 T6939 prep of,upregulation
R5465 T6941 T6942 compound BMP-6,mRNA
R5466 T6942 T6940 pobj mRNA,of
R5467 T6943 T6944 punct (,Figure
R5468 T6944 T6942 appos Figure,mRNA
R5469 T6945 T6944 nummod 11,Figure
R5470 T6946 T6942 punct ),mRNA
R5471 T6947 T6937 punct .,induced
R5472 T6948 T6956 advmod Interestingly,found
R5473 T6949 T6956 punct ",",found
R5474 T6950 T6956 prep in,found
R5475 T6951 T6953 det a,study
R5476 T6952 T6953 amod separate,study
R5477 T6953 T6950 pobj study,in
R5478 T6954 T6956 nsubj we,found
R5479 T6955 T6956 aux have,found
R5480 T6956 T6956 ROOT found,found
R5481 T6957 T6964 mark that,express
R5482 T6958 T6961 amod normal,cells
R5483 T6959 T6960 compound human,T
R5484 T6960 T6961 compound T,cells
R5485 T6961 T6964 nsubj cells,express
R5486 T6962 T6964 aux do,express
R5487 T6963 T6964 neg not,express
R5488 T6964 T6956 ccomp express,found
R5489 T6965 T6966 compound BMP-6,mRNA
R5490 T6966 T6964 dobj mRNA,express
R5491 T6967 T6964 prep after,express
R5492 T6968 T6967 pobj activation,after
R5493 T6969 T6968 punct (,activation
R5494 T6970 T6972 nmod Sivertsen,al
R5495 T6971 T6972 nmod et,al
R5496 T6972 T6968 appos al,activation
R5497 T6973 T6968 punct ",",activation
R5498 T6974 T6964 conj manuscript,express
R5499 T6975 T6974 prep in,manuscript
R5500 T6976 T6975 pobj preparation,in
R5501 T6977 T6956 punct ),found
R5502 T6978 T6956 punct .,found
R5503 T6979 T6982 advmod Next,wanted
R5504 T6980 T6982 punct ",",wanted
R5505 T6981 T6982 nsubj we,wanted
R5506 T6982 T6982 ROOT wanted,wanted
R5507 T6983 T6984 aux to,detect
R5508 T6984 T6982 xcomp detect,wanted
R5509 T6985 T6986 compound BMP-6,protein
R5510 T6986 T6984 dobj protein,detect
R5511 T6987 T6984 prep in,detect
R5512 T6988 T6989 amod normal,B-cells
R5513 T6989 T6987 pobj B-cells,in
R5514 T6990 T6982 cc and,wanted
R5515 T6991 T6982 conj tested,wanted
R5516 T6992 T6995 amod various,antibodies
R5517 T6993 T6994 advmod commercially,available
R5518 T6994 T6995 amod available,antibodies
R5519 T6995 T6991 dobj antibodies,tested
R5520 T6996 T6982 punct .,wanted
R5521 T6997 T7007 advmod However,recognize
R5522 T6998 T7007 punct ",",recognize
R5523 T6999 T7007 prep in,recognize
R5524 T7000 T7001 poss our,hands
R5525 T7001 T6999 pobj hands,in
R5526 T7002 T7004 det these,antibodies
R5527 T7003 T7004 amod anti-BMP-6,antibodies
R5528 T7004 T7007 nsubj antibodies,recognize
R5529 T7005 T7007 aux did,recognize
R5530 T7006 T7007 advmod only,recognize
R5531 T7007 T7007 ROOT recognize,recognize
R5532 T7008 T7011 det the,protein
R5533 T7009 T7011 amod recombinant,protein
R5534 T7010 T7011 compound BMP-6,protein
R5535 T7011 T7007 dobj protein,recognize
R5536 T7012 T7011 cc and,protein
R5537 T7013 T7016 neg not,protein
R5538 T7014 T7016 det the,protein
R5539 T7015 T7016 amod native,protein
R5540 T7016 T7011 conj protein,protein
R5541 T7017 T7007 punct .,recognize
R7899 T10336 T10338 amod hematopoietic,cells
R7900 T10324 T10325 amod Recent,studies
R7901 T10325 T10327 nsubj studies,demonstrated
R7902 T10326 T10327 aux have,demonstrated
R7903 T10327 T10366 ccomp demonstrated,reported
R7904 T10328 T10330 det an,role
R7905 T10329 T10330 amod important,role
R7906 T10330 T10327 dobj role,demonstrated
R7907 T10331 T10330 prep for,role
R7908 T10332 T10334 compound BMP,members
R7909 T10333 T10334 compound superfamily,members
R7910 T10334 T10331 pobj members,for
R7911 T10335 T10330 prep in,role
R7912 T10337 T10338 compound stem,cells
R7913 T10338 T10335 pobj cells,in
R7914 T10383 T10384 compound B,cells
R7915 T10339 T10330 punct ",",role
R7916 T10384 T10378 pobj cells,in
R7917 T10385 T10371 punct .,demonstrated
R7918 T10386 T10389 advmod Additionally,induced
R7919 T10340 T10341 amod early,thymocytes
R7920 T10387 T10389 punct ",",induced
R7921 T10388 T10389 nsubj BMP-6,induced
R7922 T10389 T10389 ROOT induced,induced
R7923 T10341 T10344 nmod thymocytes,]
R7924 T10390 T10391 compound cell,death
R7925 T10391 T10389 dobj death,induced
R7926 T10392 T10389 prep in,induced
R7927 T10342 T10344 nmod [,]
R7928 T10393 T10396 compound CD27,B
R7929 T10394 T10396 compound +,B
R7930 T10395 T10396 compound memory,B
R7931 T10343 T10344 nummod "6,7",]
R7932 T10396 T10397 compound B,cells
R7933 T10397 T10392 pobj cells,in
R7934 T10398 T10400 advmod as,as
R7935 T10344 T10347 nmod ],malignancies
R7936 T10399 T10400 advmod well,as
R7937 T10400 T10392 cc as,in
R7938 T10401 T10392 conj in,in
R7939 T10345 T10344 cc and,]
R7940 T10402 T10406 det a,line
R7941 T10403 T10406 compound Burkitt,line
R7942 T10404 T10405 compound lymphoma,cell
R7943 T10346 T10344 conj B-cell,]
R7944 T10405 T10406 compound cell,line
R7945 T10406 T10401 pobj line,in
R7946 T10347 T10366 nsubj malignancies,reported
R7947 T10407 T10406 punct (,line
R7948 T10408 T10406 appos Ramos,line
R7949 T10409 T10406 punct ),line
R7950 T10348 T10350 compound [,]
R7951 T10410 T10389 punct .,induced
R7952 T10411 T10414 advmod Importantly,induced
R7953 T10349 T10350 compound "8,11,12",]
R7954 T10412 T10414 punct ",",induced
R7955 T10413 T10414 nsubj BMP-6,induced
R7956 T10414 T10414 ROOT induced,induced
R7957 T10415 T10419 det a,increase
R7958 T10416 T10419 amod rapid,increase
R7959 T10417 T10416 cc and,rapid
R7960 T10418 T10416 conj marked,rapid
R7961 T10350 T10347 dobj ],malignancies
R7962 T10419 T10414 dobj increase,induced
R7963 T10420 T10419 prep in,increase
R7964 T10421 T10424 quantmod Smad-1,phosphorylation
R7965 T10351 T10347 punct ",",malignancies
R7966 T10422 T10423 compound /,5/8
R7967 T10423 T10424 nummod 5/8,phosphorylation
R7968 T10352 T10347 cc but,malignancies
R7969 T10353 T10354 det a,role
R7970 T10424 T10420 pobj phosphorylation,in
R7971 T10354 T10347 conj role,malignancies
R7972 T10425 T10414 punct .,induced
R7973 T10426 T10430 advmod Furthermore,induced
R7974 T10427 T10430 punct ",",induced
R7975 T10355 T10354 prep for,role
R7976 T10428 T10429 det the,BMP-6
R7977 T10429 T10430 nsubj BMP-6,induced
R7978 T10356 T10355 pobj BMPs,for
R7979 T10430 T10430 ROOT induced,induced
R7980 T10431 T10432 compound Smad,phosphorylation
R7981 T10432 T10434 nsubjpass phosphorylation,followed
R7982 T10357 T10356 prep in,BMPs
R7983 T10433 T10434 auxpass was,followed
R7984 T10434 T10430 advcl followed,induced
R7985 T10435 T10434 agent by,followed
R7986 T10358 T10361 amod normal,cells
R7987 T10436 T10438 det a,upregulation
R7988 T10437 T10438 amod selective,upregulation
R7989 T10438 T10435 pobj upregulation,by
R7990 T10359 T10361 amod human,cells
R7991 T10439 T10438 prep of,upregulation
R7992 T10440 T10441 compound Id1,mRNA
R7993 T10441 T10439 pobj mRNA,of
R7994 T10442 T10441 cc and,mRNA
R7995 T10360 T10361 compound B,cells
R7996 T10361 T10357 pobj cells,in
R7997 T10443 T10445 amod subsequent,protein
R7998 T10444 T10445 amod Id1,protein
R7999 T10362 T10366 aux has,reported
R8000 T10445 T10438 conj protein,upregulation
R8001 T10446 T10434 punct .,followed
R8002 T10363 T10366 advmod previously,reported
R8003 T10447 T10463 prep In,was
R8004 T10448 T10450 det the,study
R8005 T10449 T10450 amod present,study
R8006 T10364 T10366 neg not,reported
R8007 T10450 T10447 pobj study,In
R8008 T10451 T10463 punct ",",was
R8009 T10452 T10455 det the,effect
R8010 T10453 T10455 amod demonstrated,effect
R8011 T10454 T10455 amod antiproliferative,effect
R8012 T10455 T10463 nsubj effect,was
R8013 T10365 T10366 auxpass been,reported
R8014 T10456 T10455 prep of,effect
R8015 T10457 T10456 pobj BMP-6,of
R8016 T10458 T10457 prep in,BMP-6
R8017 T10366 T10366 ROOT reported,reported
R8018 T10459 T10462 amod anti-IgM,cells
R8019 T10460 T10462 amod treated,cells
R8020 T10367 T10366 punct .,reported
R8021 T10461 T10462 compound B,cells
R8022 T10462 T10458 pobj cells,in
R8023 T10463 T10463 ROOT was,was
R8024 T10464 T10463 acomp significant,was
R8025 T10368 T10370 det The,study
R8026 T10465 T10464 cc and,significant
R8027 T10466 T10464 conj dose-dependent,significant
R8028 T10467 T10463 punct .,was
R8029 T10468 T10478 advmod Importantly,neutralized
R8030 T10369 T10370 amod present,study
R8031 T10469 T10478 punct ",",neutralized
R8032 T10470 T10472 det the,effect
R8033 T10471 T10472 amod anti-proliferative,effect
R8034 T10370 T10371 nsubj study,demonstrated
R8035 T10472 T10478 nsubjpass effect,neutralized
R8036 T10473 T10472 prep of,effect
R8037 T10371 T10371 ROOT demonstrated,demonstrated
R8038 T10474 T10473 pobj BMP-6,of
R8039 T10475 T10478 aux could,neutralized
R8040 T10476 T10478 auxpass be,neutralized
R8041 T10372 T10375 det a,effect
R8042 T10477 T10478 advmod completely,neutralized
R8043 T10478 T10478 ROOT neutralized,neutralized
R8044 T10373 T10375 amod significant,effect
R8045 T10374 T10375 amod antiproliferative,effect
R8046 T10375 T10371 dobj effect,demonstrated
R8047 T10479 T10478 agent by,neutralized
R8048 T10376 T10375 prep of,effect
R8049 T10480 T10481 det the,use
R8050 T10481 T10479 pobj use,by
R8051 T10377 T10376 pobj BMP-6,of
R8052 T10482 T10481 prep of,use
R8053 T10483 T10485 det a,inhibitor
R8054 T10484 T10485 amod natural,inhibitor
R8055 T10378 T10377 prep in,BMP-6
R8056 T10485 T10482 pobj inhibitor,of
R8057 T10486 T10481 punct ",",use
R8058 T10379 T10380 amod peripheral,blood
R8059 T10487 T10481 appos Noggin,use
R8060 T10488 T10478 punct .,neutralized
R8061 T10489 T10490 nsubj This,is
R8062 T10490 T10490 ROOT is,is
R8063 T10491 T10490 prep in,is
R8064 T10380 T10384 compound blood,cells
R8065 T10492 T10491 pobj line,in
R8066 T10493 T10492 prep with,line
R8067 T10494 T10493 pobj others,with
R8068 T10495 T10490 punct ",",is
R8069 T10381 T10383 compound CD19,B
R8070 T10496 T10490 advcl showing,is
R8071 T10497 T10500 mark that,function
R8072 T10382 T10383 compound +,B
R8073 T10498 T10500 nsubj Noggin,function
R8074 T10499 T10500 aux can,function
R8075 T10500 T10496 ccomp function,showing
R8076 T10541 T10547 punct ",",demonstrated
R8077 T10501 T10500 prep as,function
R8078 T10502 T10504 det a,antagonist
R8079 T10542 T10543 amod bifunctional,effects
R8080 T10543 T10547 nsubj effects,demonstrated
R8081 T10503 T10504 compound BMP-6,antagonist
R8082 T10504 T10501 pobj antagonist,as
R8083 T10505 T10507 compound [,]
R8084 T10544 T10547 aux have,demonstrated
R8085 T10506 T10507 compound "21,22",]
R8086 T10507 T10504 appos ],antagonist
R8087 T10545 T10547 advmod also,demonstrated
R8088 T10508 T10490 punct .,is
R8089 T10509 T10522 prep In,neutralized
R8090 T10546 T10547 auxpass been,demonstrated
R8091 T10510 T10509 pobj addition,In
R8092 T10511 T10522 punct ",",neutralized
R8093 T10512 T10513 det the,combination
R8094 T10547 T10547 ROOT demonstrated,demonstrated
R8095 T10513 T10522 nsubj combination,neutralized
R8096 T10514 T10513 prep of,combination
R8097 T10548 T10547 prep for,demonstrated
R8098 T10515 T10520 amod soluble,proteins
R8099 T10516 T10519 nmod BMP-RIB-Fc,fusion
R8100 T10517 T10516 cc and,BMP-RIB-Fc
R8101 T10549 T10548 pobj BMPs,for
R8102 T10518 T10516 conj BMP-RII-Fc,BMP-RIB-Fc
R8103 T10519 T10520 compound fusion,proteins
R8104 T10520 T10514 pobj proteins,of
R8105 T10550 T10547 punct .,demonstrated
R8106 T10521 T10522 advmod also,neutralized
R8107 T10522 T10522 ROOT neutralized,neutralized
R8108 T10523 T10525 det the,effect
R8109 T10551 T10558 mark Whereas,shown
R8110 T10524 T10525 amod anti-proliferative,effect
R8111 T10525 T10522 dobj effect,neutralized
R8112 T10526 T10525 prep of,effect
R8113 T10527 T10526 pobj BMP-6,of
R8114 T10528 T10522 prep in,neutralized
R8115 T10552 T10558 nsubjpass several,shown
R8116 T10529 T10531 amod human,cells
R8117 T10530 T10531 compound B,cells
R8118 T10553 T10552 prep of,several
R8119 T10554 T10555 det the,BMPs
R8120 T10531 T10528 pobj cells,in
R8121 T10555 T10553 pobj BMPs,of
R8122 T10532 T10522 punct .,neutralized
R8123 T10533 T10547 advmod Interestingly,demonstrated
R8124 T10556 T10558 aux have,shown
R8125 T10534 T10547 punct ",",demonstrated
R8126 T10535 T10547 prep as,demonstrated
R8127 T10536 T10535 prep for,as
R8128 T10537 T10540 amod other,members
R8129 T10557 T10558 auxpass been,shown
R8130 T10538 T10540 compound TGF,members
R8131 T10539 T10540 compound family,members
R8132 T10540 T10536 pobj members,for
R8133 T10558 T10591 advcl shown,reported
R8134 T10559 T10560 aux to,promote
R8135 T10560 T10558 xcomp promote,shown
R8136 T10575 T10578 nmod ],cells
R8137 T10576 T10575 cc and,]
R8138 T10561 T10560 dobj proliferation,promote
R8139 T10577 T10575 conj granulosa,]
R8140 T10578 T10591 nsubjpass cells,reported
R8141 T10562 T10560 prep in,promote
R8142 T10579 T10581 nmod [,]
R8143 T10580 T10581 nummod 25,]
R8144 T10563 T10565 amod various,types
R8145 T10581 T10578 dobj ],cells
R8146 T10564 T10565 compound cell,types
R8147 T10565 T10562 pobj types,in
R8148 T10582 T10581 punct ",",]
R8149 T10583 T10584 amod antiproliferative,effects
R8150 T10566 T10565 prep including,types
R8151 T10584 T10581 conj effects,]
R8152 T10585 T10584 cc and,effects
R8153 T10567 T10568 nmod condrocytes,[
R8154 T10586 T10584 conj induction,effects
R8155 T10587 T10586 prep of,induction
R8156 T10588 T10587 pobj apoptosis,of
R8157 T10568 T10570 nmod [,]
R8158 T10589 T10591 aux has,reported
R8159 T10590 T10591 auxpass been,reported
R8160 T10591 T10591 ROOT reported,reported
R8161 T10592 T10591 prep for,reported
R8162 T10593 T10597 nmod B,cells
R8163 T10569 T10570 nummod 23,]
R8164 T10594 T10593 cc and,B
R8165 T10595 T10593 conj T,B
R8166 T10596 T10597 compound lineage,cells
R8167 T10570 T10566 pobj ],including
R8168 T10597 T10592 pobj cells,for
R8169 T10598 T10591 punct .,reported
R8170 T10571 T10570 punct ",",]
R8171 T10599 T10600 amod Similar,effects
R8172 T10600 T10615 nsubjpass effects,demonstrated
R8173 T10601 T10602 mark as,demonstrated
R8174 T10572 T10578 nsubj liver,cells
R8175 T10602 T10600 advcl demonstrated,effects
R8176 T10573 T10575 nmod [,]
R8177 T10603 T10602 prep for,demonstrated
R8178 T10574 T10575 nummod 24,]
R8179 T10604 T10603 pobj BMP-6,for
R8180 T10605 T10604 prep on,BMP-6
R8181 T10639 T10640 auxpass been,reported
R8182 T10606 T10608 amod human,cells
R8183 T10607 T10608 compound B,cells
R8184 T10608 T10605 pobj cells,on
R8185 T10609 T10602 prep in,demonstrated
R8186 T10610 T10612 det the,study
R8187 T10611 T10612 amod present,study
R8188 T10640 T10640 ROOT reported,reported
R8189 T10612 T10609 pobj study,in
R8190 T10613 T10615 punct ",",demonstrated
R8191 T10614 T10615 auxpass were,demonstrated
R8192 T10641 T10642 aux to,induce
R8193 T10615 T10615 ROOT demonstrated,demonstrated
R8194 T10616 T10615 prep for,demonstrated
R8195 T10617 T10616 pobj BMP-2,for
R8196 T10642 T10640 xcomp induce,reported
R8197 T10618 T10617 punct ",",BMP-2
R8198 T10619 T10617 appos 4,BMP-2
R8199 T10643 T10642 dobj apoptosis,induce
R8200 T10620 T10617 punct ",",BMP-2
R8201 T10621 T10617 conj 6,BMP-2
R8202 T10622 T10621 cc and,6
R8203 T10644 T10643 punct ",",apoptosis
R8204 T10623 T10621 conj -7,6
R8205 T10624 T10623 prep in,-7
R8206 T10625 T10627 amod human,cells
R8207 T10645 T10643 prep including,apoptosis
R8208 T10626 T10627 compound myeloma,cells
R8209 T10627 T10624 pobj cells,in
R8210 T10646 T10645 prep in,including
R8211 T10628 T10630 compound [,]
R8212 T10629 T10630 compound 9-11,]
R8213 T10630 T10617 appos ],BMP-2
R8214 T10631 T10615 punct .,demonstrated
R8215 T10632 T10633 amod Other,members
R8216 T10633 T10640 nsubj members,reported
R8217 T10647 T10649 compound mouse,lineage
R8218 T10634 T10633 prep of,members
R8219 T10635 T10636 det the,BMP-family
R8220 T10636 T10634 pobj BMP-family,of
R8221 T10648 T10649 compound B,lineage
R8222 T10637 T10640 aux have,reported
R8223 T10638 T10640 advmod also,reported
R8224 T10649 T10650 compound lineage,cells
R8225 T10650 T10646 pobj cells,in
R8226 T10651 T10653 nmod [,]
R8227 T10652 T10653 nummod 26,]
R8228 T10653 T10645 pobj ],including
R8229 T10671 T10683 mark that,is
R8230 T10672 T10673 det the,role
R8231 T10654 T10640 punct .,reported
R8232 T10673 T10683 nsubj role,is
R8233 T10674 T10673 prep of,role
R8234 T10655 T10658 advmod Additionally,inhibits
R8235 T10675 T10674 pobj BMPs,of
R8236 T10676 T10675 prep in,BMPs
R8237 T10677 T10678 det the,regulation
R8238 T10656 T10658 punct ",",inhibits
R8239 T10678 T10676 pobj regulation,in
R8240 T10679 T10678 prep of,regulation
R8241 T10680 T10679 pobj proliferation,of
R8242 T10657 T10658 nsubj BMP-4,inhibits
R8243 T10658 T10658 ROOT inhibits,inhibits
R8244 T10659 T10661 nmod thymocyte,[
R8245 T10681 T10680 cc and,proliferation
R8246 T10682 T10680 conj apoptosis,proliferation
R8247 T10660 T10661 compound proliferation,[
R8248 T10683 T10670 ccomp is,suggest
R8249 T10684 T10685 advmod highly,cell
R8250 T10685 T10686 compound cell,type
R8251 T10661 T10658 dobj [,inhibits
R8252 T10686 T10687 npadvmod type,dependent
R8253 T10687 T10683 acomp dependent,is
R8254 T10688 T10670 punct .,suggest
R8255 T10689 T10690 aux To,examine
R8256 T10690 T10702 advcl examine,analysed
R8257 T10662 T10663 nummod 6,]
R8258 T10691 T10693 advmod how,exerts
R8259 T10692 T10693 nsubj BMP-6,exerts
R8260 T10693 T10690 ccomp exerts,examine
R8261 T10694 T10696 poss its,effects
R8262 T10695 T10696 amod functional,effects
R8263 T10663 T10661 appos ],[
R8264 T10696 T10693 dobj effects,exerts
R8265 T10697 T10696 prep in,effects
R8266 T10698 T10699 compound B,cells
R8267 T10664 T10658 punct .,inhibits
R8268 T10699 T10697 pobj cells,in
R8269 T10700 T10702 punct ",",analysed
R8270 T10701 T10702 nsubj we,analysed
R8271 T10665 T10670 advcl Taken,suggest
R8272 T10702 T10702 ROOT analysed,analysed
R8273 T10703 T10705 compound BMP,expression
R8274 T10666 T10665 advmod together,Taken
R8275 T10704 T10705 compound receptor,expression
R8276 T10705 T10702 dobj expression,analysed
R8277 T10706 T10705 prep by,expression
R8278 T10667 T10670 punct ",",suggest
R8279 T10707 T10709 amod western,analysis
R8280 T10708 T10709 compound blot,analysis
R8281 T10668 T10669 det these,data
R8282 T10709 T10706 pobj analysis,by
R8283 T10710 T10702 punct .,analysed
R8284 T10711 T10714 amod Human,cells
R8285 T10669 T10670 nsubj data,suggest
R8286 T10712 T10714 amod peripheral,cells
R8287 T10713 T10714 compound B,cells
R8288 T10714 T10716 nsubjpass cells,found
R8289 T10670 T10670 ROOT suggest,suggest
R8290 T10715 T10716 auxpass were,found
R8291 T10716 T10716 ROOT found,found
R8292 T10717 T10718 aux to,express
R8293 T10737 T10723 relcl signal,receptors
R8294 T10718 T10716 advcl express,found
R8295 T10719 T10721 det the,type
R8296 T10720 T10721 compound BMP,type
R8297 T10738 T10737 prep after,signal
R8298 T10721 T10718 dobj type,express
R8299 T10722 T10723 nsubj I,receptors
R8300 T10723 T10721 relcl receptors,type
R8301 T10739 T10738 pobj binding,after
R8302 T10724 T10723 dobj Act-RIA,receptors
R8303 T10725 T10724 cc and,Act-RIA
R8304 T10740 T10739 prep of,binding
R8305 T10726 T10724 conj BMP-RIB,Act-RIA
R8306 T10727 T10726 punct ",",BMP-RIB
R8307 T10728 T10726 cc and,BMP-RIB
R8308 T10729 T10730 det the,type
R8309 T10741 T10742 amod several,BMPs
R8310 T10730 T10726 conj type,BMP-RIB
R8311 T10731 T10732 compound II-receptors,BMP-RII
R8312 T10732 T10724 conj BMP-RII,Act-RIA
R8313 T10733 T10732 cc and,BMP-RII
R8314 T10734 T10732 conj Act-RIIb,BMP-RII
R8315 T10735 T10724 punct ",",Act-RIA
R8316 T10736 T10737 nsubj which,signal
R8317 T10742 T10740 pobj BMPs,of
R8318 T10743 T10742 punct ",",BMPs
R8319 T10744 T10742 prep including,BMPs
R8320 T10745 T10746 compound BMP-6,[
R8321 T10746 T10744 pobj [,including
R8322 T10747 T10748 nummod "16,13",]
R8323 T10748 T10746 appos ],[
R8324 T10834 T10838 nsubjpass BMP-2,shown
R8325 T10835 T10838 aux has,shown
R8326 T10749 T10716 punct .,found
R8327 T10836 T10838 advmod also,shown
R8328 T10837 T10838 auxpass been,shown
R8329 T10750 T10752 aux To,explore
R8330 T10838 T10838 ROOT shown,shown
R8331 T10839 T10840 aux to,induce
R8332 T10840 T10838 xcomp induce,shown
R8333 T10751 T10752 advmod further,explore
R8334 T10841 T10840 dobj phosphorylation,induce
R8335 T10842 T10841 prep of,phosphorylation
R8336 T10752 T10761 advcl explore,is
R8337 T10843 T10846 nummod p38,]
R8338 T10844 T10846 nmod [,]
R8339 T10845 T10846 nummod 29,]
R8340 T10846 T10842 pobj ],of
R8341 T10753 T10754 nsubj BMP-6,induced
R8342 T10847 T10838 punct .,shown
R8343 T10848 T10857 advmod Thus,represent
R8344 T10754 T10761 advcl induced,is
R8345 T10849 T10857 punct ",",represent
R8346 T10850 T10857 nsubj phosphorylation,represent
R8347 T10851 T10850 prep of,phosphorylation
R8348 T10755 T10754 prt signalling,induced
R8349 T10852 T10851 pobj p38,of
R8350 T10853 T10850 punct ",",phosphorylation
R8351 T10854 T10850 conj STAT3,phosphorylation
R8352 T10756 T10755 punct ",",signalling
R8353 T10855 T10854 cc and,STAT3
R8354 T10856 T10854 conj Smad1/5/8,STAT3
R8355 T10757 T10761 nsubj activation,is
R8356 T10857 T10857 ROOT represent,represent
R8357 T10858 T10860 amod important,pathways
R8358 T10859 T10860 amod BMP-signalling,pathways
R8359 T10758 T10757 prep of,activation
R8360 T10860 T10857 dobj pathways,represent
R8361 T10861 T10862 nsubj that,mediated
R8362 T10862 T10860 relcl mediated,pathways
R8363 T10863 T10864 det the,effects
R8364 T10864 T10862 dobj effects,mediated
R8365 T10865 T10864 prep of,effects
R8366 T10759 T10760 amod several,pathways
R8367 T10866 T10865 pobj BMPs,of
R8368 T10867 T10866 cc and,BMPs
R8369 T10868 T10869 advmod even,cross-talk
R8370 T10760 T10758 pobj pathways,of
R8371 T10869 T10862 npadvmod cross-talk,mediated
R8372 T10870 T10869 prep between,cross-talk
R8373 T10871 T10872 det these,pathways
R8374 T10761 T10761 ROOT is,is
R8375 T10872 T10870 pobj pathways,between
R8376 T10873 T10875 aux has,reported
R8377 T10874 T10875 auxpass been,reported
R8378 T10762 T10761 acomp possible,is
R8379 T10875 T10857 conj reported,represent
R8380 T10876 T10878 compound [,]
R8381 T10763 T10761 punct .,is
R8382 T10877 T10878 compound "29,30",]
R8383 T10878 T10875 oprd ],reported
R8384 T10879 T10857 punct .,represent
R8385 T10764 T10767 det The,pathway
R8386 T10880 T10886 prep In,were
R8387 T10881 T10883 det the,study
R8388 T10882 T10883 amod present,study
R8389 T10765 T10767 amod major,pathway
R8390 T10883 T10880 pobj study,In
R8391 T10884 T10886 punct ",",were
R8392 T10885 T10886 nsubj we,were
R8393 T10766 T10767 amod signalling,pathway
R8394 T10886 T10886 ROOT were,were
R8395 T10887 T10886 neg not,were
R8396 T10888 T10886 acomp able,were
R8397 T10767 T10772 nsubj pathway,is
R8398 T10889 T10890 aux to,detect
R8399 T10890 T10888 xcomp detect,able
R8400 T10891 T10892 amod BMP-6-induced,changes
R8401 T10768 T10767 acl known,pathway
R8402 T10892 T10890 dobj changes,detect
R8403 T10893 T10890 prep in,detect
R8404 T10894 T10896 det the,status
R8405 T10895 T10896 compound phosphorylation,status
R8406 T10769 T10768 prep to,known
R8407 T10896 T10893 pobj status,in
R8408 T10897 T10896 prep of,status
R8409 T10770 T10769 pobj date,to
R8410 T10898 T10897 pobj STAT3,of
R8411 T10899 T10898 cc or,STAT3
R8412 T10771 T10767 punct ",",pathway
R8413 T10900 T10898 conj p38,STAT3
R8414 T10901 T10896 prep in,status
R8415 T10902 T10905 amod human,cells
R8416 T10772 T10772 ROOT is,is
R8417 T10903 T10905 amod peripheral,cells
R8418 T10904 T10905 compound B,cells
R8419 T10773 T10772 attr activation,is
R8420 T10905 T10901 pobj cells,in
R8421 T10906 T10886 punct .,were
R8422 T10907 T10917 advmod Instead,revealed
R8423 T10774 T10773 prep of,activation
R8424 T10908 T10917 punct ",",revealed
R8425 T10909 T10913 det a,phosphorylation
R8426 T10775 T10774 pobj R-Smads,of
R8427 T10910 T10913 amod rapid,phosphorylation
R8428 T10911 T10910 cc and,rapid
R8429 T10912 T10910 conj marked,rapid
R8430 T10776 T10778 compound [,]
R8431 T10913 T10917 nsubjpass phosphorylation,revealed
R8432 T10914 T10913 prep of,phosphorylation
R8433 T10915 T10914 pobj Smad1/5/8,of
R8434 T10777 T10778 compound "13,27",]
R8435 T10778 T10773 appos ],activation
R8436 T10916 T10917 auxpass was,revealed
R8437 T10779 T10772 punct .,is
R8438 T10917 T10917 ROOT revealed,revealed
R8439 T10918 T10917 punct .,revealed
R8440 T10780 T10787 prep In,shown
R8441 T10919 T10926 prep In,found
R8442 T10920 T10922 det a,study
R8443 T10921 T10922 amod parallel,study
R8444 T10781 T10782 det that,respect
R8445 T10922 T10919 pobj study,In
R8446 T10923 T10926 punct ",",found
R8447 T10782 T10780 pobj respect,In
R8448 T10924 T10926 nsubj we,found
R8449 T10925 T10926 aux have,found
R8450 T10783 T10787 punct ",",shown
R8451 T10926 T10926 ROOT found,found
R8452 T10927 T10931 mark that,induced
R8453 T10784 T10787 nsubjpass BMPs,shown
R8454 T10928 T10929 amod other,BMPs
R8455 T10929 T10931 nsubj BMPs,induced
R8456 T10785 T10787 aux have,shown
R8457 T10930 T10931 advmod also,induced
R8458 T10786 T10787 auxpass been,shown
R8459 T10787 T10787 ROOT shown,shown
R8460 T10788 T10789 aux to,exert
R8461 T10931 T10926 ccomp induced,found
R8462 T10932 T10931 dobj phosphorylation,induced
R8463 T10933 T10932 prep of,phosphorylation
R8464 T10934 T10933 pobj Smad1/5/8,of
R8465 T10789 T10787 xcomp exert,shown
R8466 T10935 T10932 prep in,phosphorylation
R8467 T10936 T10938 amod peripheral,cells
R8468 T10790 T10791 amod antiproliferative,effects
R8469 T10937 T10938 compound B,cells
R8470 T10938 T10935 pobj cells,in
R8471 T10939 T10942 punct (,shown
R8472 T10791 T10789 dobj effects,exert
R8473 T10940 T10942 nsubjpass data,shown
R8474 T10941 T10942 neg not,shown
R8475 T10942 T10931 parataxis shown,induced
R8476 T10792 T10791 prep in,effects
R8477 T10943 T10942 punct ),shown
R8478 T10944 T10926 punct .,found
R8479 T10793 T10794 compound B,lineage
R8480 T10945 T10948 nsubj We,pursuing
R8481 T10946 T10948 aux are,pursuing
R8482 T10947 T10948 advmod currently,pursuing
R8483 T10794 T10795 compound lineage,cells
R8484 T10948 T10948 ROOT pursuing,pursuing
R8485 T10949 T10950 compound microarray,studies
R8486 T10795 T10792 pobj cells,in
R8487 T10950 T10948 dobj studies,pursuing
R8488 T10951 T10952 aux to,identify
R8489 T10952 T10948 advcl identify,pursuing
R8490 T10796 T10789 prep via,exert
R8491 T10953 T10955 det the,pathways
R8492 T10954 T10955 amod signalling,pathways
R8493 T10955 T10952 dobj pathways,identify
R8494 T10797 T10796 pobj phosphorylation,via
R8495 T10956 T10955 cc and,pathways
R8496 T10957 T10958 compound target,genes
R8497 T10958 T10955 conj genes,pathways
R8498 T10798 T10797 prep of,phosphorylation
R8499 T10959 T10962 nsubjpass that,regulated
R8500 T10960 T10962 auxpass are,regulated
R8501 T10961 T10962 advmod differently,regulated
R8502 T10962 T10955 relcl regulated,pathways
R8503 T10799 T10802 amod R-Smad,]
R8504 T10963 T10962 agent by,regulated
R8505 T10964 T10966 det the,BMPs
R8506 T10800 T10802 compound [,]
R8507 T10965 T10966 amod various,BMPs
R8508 T10966 T10963 pobj BMPs,by
R8509 T10967 T10966 prep in,BMPs
R8510 T10801 T10802 compound "11,28",]
R8511 T10968 T10970 amod human,cells
R8512 T10969 T10970 compound B,cells
R8513 T10970 T10967 pobj cells,in
R8514 T10971 T10948 punct .,pursuing
R8515 T10972 T10978 nsubj Upregulation,is
R8516 T10973 T10972 prep of,Upregulation
R8517 T10802 T10798 pobj ],of
R8518 T10974 T10973 pobj Id1,of
R8519 T10975 T10972 prep via,Upregulation
R8520 T10976 T10977 compound Smad1/5/8,phosphorylation
R8521 T10803 T10787 punct .,shown
R8522 T10977 T10975 pobj phosphorylation,via
R8523 T10978 T10978 ROOT is,is
R8524 T10804 T10809 advmod Furthermore,shown
R8525 T10805 T10809 punct ",",shown
R8526 T10979 T10981 det a,mechanism
R8527 T10980 T10981 amod known,mechanism
R8528 T10806 T10809 nsubjpass BMP-2,shown
R8529 T10981 T10978 attr mechanism,is
R8530 T10982 T10981 prep for,mechanism
R8531 T10807 T10809 aux has,shown
R8532 T10983 T10984 nsubj BMP-6,signalling
R8533 T10984 T10982 pcomp signalling,for
R8534 T10985 T10984 prep in,signalling
R8535 T10808 T10809 auxpass been,shown
R8536 T10986 T10988 amod other,systems
R8537 T10987 T10988 compound cell,systems
R8538 T10988 T10985 pobj systems,in
R8539 T10809 T10809 ROOT shown,shown
R8540 T10989 T10991 compound [,]
R8541 T10990 T10991 compound "31,32",]
R8542 T10991 T10984 dobj ],signalling
R8543 T10810 T10811 aux to,induce
R8544 T10992 T10991 cc and,]
R8545 T10993 T10991 conj regulation,]
R8546 T10811 T10809 xcomp induce,shown
R8547 T10812 T10811 dobj activation,induce
R8548 T10813 T10812 prep of,activation
R8549 T10994 T10993 prep of,regulation
R8550 T10995 T10994 pobj Id-proteins,of
R8551 T10814 T10813 pobj STAT3,of
R8552 T10996 T10997 auxpass is,thought
R8553 T10997 T10978 conj thought,is
R8554 T10815 T10812 prep in,activation
R8555 T10998 T10999 aux to,be
R8556 T10999 T10997 xcomp be,thought
R8557 T11000 T11002 det an,mechanism
R8558 T10816 T10817 compound myeloma,cells
R8559 T11001 T11002 amod important,mechanism
R8560 T11002 T10999 attr mechanism,be
R8561 T11003 T11002 prep for,mechanism
R8562 T10817 T10815 pobj cells,in
R8563 T11004 T11005 compound Smad-signalling,[
R8564 T11005 T11007 nmod [,]
R8565 T11006 T11007 nummod 17,]
R8566 T11007 T11003 pobj ],for
R8567 T11008 T10978 punct .,is
R8568 T11009 T11017 prep In,revealed
R8569 T10818 T10820 nmod [,]
R8570 T11010 T11012 det the,study
R8571 T11011 T11012 amod present,study
R8572 T11012 T11009 pobj study,In
R8573 T10819 T10820 nummod 9,]
R8574 T11013 T11017 punct ",",revealed
R8575 T11014 T11016 amod real-time,experiments
R8576 T10820 T10809 dobj ],shown
R8577 T11015 T11016 compound RT-PCR,experiments
R8578 T11016 T11017 nsubj experiments,revealed
R8579 T11017 T11017 ROOT revealed,revealed
R8580 T10821 T10809 punct .,shown
R8581 T11018 T11021 det a,upregulation
R8582 T11019 T11021 amod specific,upregulation
R8583 T11020 T11021 advmod four-fold,upregulation
R8584 T10822 T10829 advmod However,investigated
R8585 T11021 T11017 dobj upregulation,revealed
R8586 T11022 T11021 prep for,upregulation
R8587 T11023 T11022 pobj Id1,for
R8588 T10823 T10829 punct ",",investigated
R8589 T11024 T11021 prep in,upregulation
R8590 T11025 T11026 compound BMP-6-treated,B
R8591 T11026 T11027 compound B,cells
R8592 T10824 T10829 nsubjpass phosphorylation,investigated
R8593 T11027 T11024 pobj cells,in
R8594 T10825 T10824 prep of,phosphorylation
R8595 T10826 T10825 pobj R-Smad,of
R8596 T10827 T10829 auxpass was,investigated
R8597 T11028 T11017 punct ",",revealed
R8598 T11029 T11035 mark while,remained
R8599 T10828 T10829 neg not,investigated
R8600 T11030 T11031 det the,amount
R8601 T11031 T11035 nsubj amount,remained
R8602 T10829 T10829 ROOT investigated,investigated
R8603 T11032 T11031 prep of,amount
R8604 T11033 T11032 pobj Id2,of
R8605 T11034 T11035 nsubj Id4,remained
R8606 T10830 T10829 prep in,investigated
R8607 T11035 T11017 advcl remained,revealed
R8608 T11036 T11035 acomp unchanged,remained
R8609 T10831 T10832 det that,study
R8610 T11037 T11017 punct .,revealed
R8611 T11038 T11046 prep In,demonstrated
R8612 T11039 T11038 pobj agreement,In
R8613 T11040 T11039 prep with,agreement
R8614 T11041 T11040 pobj this,with
R8615 T11042 T11046 punct ",",demonstrated
R8616 T11043 T11045 amod western,analysis
R8617 T11044 T11045 compound blot,analysis
R8618 T10832 T10830 pobj study,in
R8619 T11045 T11046 nsubj analysis,demonstrated
R8620 T11046 T11046 ROOT demonstrated,demonstrated
R8621 T11047 T11048 det an,upregulation
R8622 T10833 T10829 punct .,investigated
R8623 T11048 T11046 dobj upregulation,demonstrated
R8624 T11049 T11048 prep of,upregulation
R8625 T11050 T11051 amod Id1,protein
R8626 T11051 T11049 pobj protein,of
R8627 T11125 T11123 pobj interest,of
R8628 T11052 T11046 punct ",",demonstrated
R8629 T11053 T11062 mark while,remained
R8630 T11054 T11055 det the,amount
R8631 T11055 T11062 nsubj amount,remained
R8632 T11056 T11055 prep of,amount
R8633 T11126 T11122 punct .,is
R8634 T11057 T11056 pobj Id2,of
R8635 T11127 T11132 prep In,is
R8636 T11058 T11057 cc and,Id2
R8637 T11128 T11129 det that,respect
R8638 T11059 T11057 conj Id3,Id2
R8639 T11060 T11061 compound protein,levels
R8640 T11061 T11062 nsubj levels,remained
R8641 T11129 T11127 pobj respect,In
R8642 T11062 T11046 advcl remained,demonstrated
R8643 T11063 T11062 acomp unchanged,remained
R8644 T11130 T11132 punct ",",is
R8645 T11064 T11046 punct .,demonstrated
R8646 T11065 T11070 advmod Previously,considered
R8647 T11131 T11132 nsubj it,is
R8648 T11066 T11070 punct ",",considered
R8649 T11067 T11070 nsubjpass Id1,considered
R8650 T11068 T11070 aux has,considered
R8651 T11132 T11132 ROOT is,is
R8652 T11069 T11070 auxpass been,considered
R8653 T11070 T11070 ROOT considered,considered
R8654 T11133 T11132 acomp noteworthy,is
R8655 T11071 T11074 neg not,expressed
R8656 T11072 T11074 aux to,expressed
R8657 T11134 T11143 mark that,induces
R8658 T11135 T11136 amod TGF-β,signalling
R8659 T11073 T11074 auxpass be,expressed
R8660 T11074 T11070 xcomp expressed,considered
R8661 T11075 T11074 prep in,expressed
R8662 T11136 T11143 nsubj signalling,induces
R8663 T11076 T11078 amod later,stages
R8664 T11077 T11078 amod developmental,stages
R8665 T11078 T11075 pobj stages,in
R8666 T11079 T11074 prep than,expressed
R8667 T11080 T11081 amod pro-B,cells
R8668 T11081 T11079 pobj cells,than
R8669 T11137 T11136 prep in,signalling
R8670 T11082 T11084 compound [,]
R8671 T11083 T11084 compound "33,34",]
R8672 T11084 T11081 appos ],cells
R8673 T11138 T11142 amod early,cells
R8674 T11085 T11084 punct ",",]
R8675 T11086 T11084 cc and,]
R8676 T11139 T11138 cc and,early
R8677 T11087 T11089 poss its,expression
R8678 T11088 T11089 amod constitutive,expression
R8679 T11089 T11092 nsubjpass expression,reported
R8680 T11140 T11138 conj mature,early
R8681 T11090 T11092 aux has,reported
R8682 T11091 T11092 auxpass been,reported
R8683 T11141 T11142 compound B,cells
R8684 T11092 T11070 conj reported,considered
R8685 T11093 T11094 aux to,impair
R8686 T11094 T11092 xcomp impair,reported
R8687 T11095 T11098 compound mouse,development
R8688 T11142 T11137 pobj cells,in
R8689 T11096 T11098 compound B,development
R8690 T11097 T11098 compound cell,development
R8691 T11098 T11094 dobj development,impair
R8692 T11143 T11132 ccomp induces,is
R8693 T11099 T11101 nmod [,]
R8694 T11100 T11101 nummod 35,]
R8695 T11144 T11145 preconj both,Id2
R8696 T11101 T11098 appos ],development
R8697 T11102 T11092 punct .,reported
R8698 T11103 T11122 advmod Therefore,is
R8699 T11145 T11148 amod Id2,expression
R8700 T11104 T11122 punct ",",is
R8701 T11105 T11106 poss our,demonstration
R8702 T11146 T11145 cc and,Id2
R8703 T11106 T11122 nsubj demonstration,is
R8704 T11107 T11106 prep of,demonstration
R8705 T11108 T11110 det the,upregulation
R8706 T11147 T11145 conj Id3,Id2
R8707 T11109 T11110 amod time-dependent,upregulation
R8708 T11110 T11107 pobj upregulation,of
R8709 T11111 T11110 prep of,upregulation
R8710 T11112 T11113 compound Id1,mRNA
R8711 T11148 T11151 compound expression,]
R8712 T11149 T11151 compound [,]
R8713 T11113 T11111 pobj mRNA,of
R8714 T11150 T11151 compound "36,37",]
R8715 T11114 T11110 cc and,upregulation
R8716 T11115 T11110 conj protein,upregulation
R8717 T11116 T11110 prep in,upregulation
R8718 T11117 T11121 amod mature,cells
R8719 T11118 T11121 amod normal,cells
R8720 T11151 T11143 dobj ],induces
R8721 T11119 T11121 amod human,cells
R8722 T11120 T11121 compound B,cells
R8723 T11121 T11116 pobj cells,in
R8724 T11122 T11122 ROOT is,is
R8725 T11152 T11143 punct ",",induces
R8726 T11123 T11122 prep of,is
R8727 T11124 T11125 amod particular,interest
R8728 T11153 T11143 cc but,induces
R8729 T11154 T11155 neg not,Id1
R8730 T11155 T11143 conj Id1,induces
R8731 T11156 T11159 punct (,shown
R8732 T11222 T11203 punct .,found
R8733 T11157 T11159 nsubjpass data,shown
R8734 T11223 T11228 advmod However,induce
R8735 T11224 T11228 punct ",",induce
R8736 T11158 T11159 neg not,shown
R8737 T11225 T11228 nsubj BMP-6,induce
R8738 T11159 T11155 parataxis shown,Id1
R8739 T11226 T11228 aux did,induce
R8740 T11227 T11228 neg not,induce
R8741 T11228 T11228 ROOT induce,induce
R8742 T11160 T11159 punct ),shown
R8743 T11229 T11230 amod significant,changes
R8744 T11230 T11228 dobj changes,induce
R8745 T11161 T11132 punct .,is
R8746 T11231 T11230 prep in,changes
R8747 T11232 T11234 det the,expression
R8748 T11162 T11166 advmod Interestingly,show
R8749 T11233 T11234 compound protein,expression
R8750 T11234 T11231 pobj expression,in
R8751 T11235 T11234 prep of,expression
R8752 T11163 T11166 punct ",",show
R8753 T11236 T11235 pobj Id2,of
R8754 T11237 T11236 cc and,Id2
R8755 T11238 T11236 conj Id3,Id2
R8756 T11164 T11165 det these,results
R8757 T11239 T11228 punct .,induce
R8758 T11240 T11242 nsubjpass It,believed
R8759 T11241 T11242 auxpass is,believed
R8760 T11165 T11166 nsubj results,show
R8761 T11242 T11242 ROOT believed,believed
R8762 T11243 T11246 mark that,block
R8763 T11244 T11246 advmod Id,block
R8764 T11166 T11166 ROOT show,show
R8765 T11245 T11246 nsubj proteins,block
R8766 T11246 T11242 ccomp block,believed
R8767 T11247 T11246 dobj differentiation,block
R8768 T11248 T11246 cc and,block
R8769 T11249 T11246 conj promote,block
R8770 T11250 T11249 dobj proliferation,promote
R8771 T11167 T11174 mark that,regulate
R8772 T11251 T11249 prep in,promote
R8773 T11252 T11254 amod various,types
R8774 T11168 T11169 amod various,members
R8775 T11253 T11254 compound cell,types
R8776 T11254 T11251 pobj types,in
R8777 T11255 T11257 compound [,]
R8778 T11169 T11174 nsubj members,regulate
R8779 T11256 T11257 compound "39,33",]
R8780 T11257 T11246 npadvmod ],block
R8781 T11258 T11242 punct .,believed
R8782 T11170 T11169 prep of,members
R8783 T11259 T11261 advmod Id,act
R8784 T11260 T11261 nsubj proteins,act
R8785 T11171 T11173 det the,family
R8786 T11261 T11261 ROOT act,act
R8787 T11262 T11261 prep as,act
R8788 T11263 T11264 amod dominant-negative,inhibitors
R8789 T11264 T11262 pobj inhibitors,as
R8790 T11172 T11173 compound TGF-β,family
R8791 T11265 T11264 prep of,inhibitors
R8792 T11266 T11265 pobj E-proteins,of
R8793 T11173 T11170 pobj family,of
R8794 T11267 T11266 cc and,E-proteins
R8795 T11268 T11266 conj Pax5,E-proteins
R8796 T11269 T11261 conj function,act
R8797 T11270 T11269 prep by,function
R8798 T11174 T11166 ccomp regulate,show
R8799 T11271 T11270 pcomp forming,by
R8800 T11272 T11271 dobj dimers,forming
R8801 T11175 T11176 compound Id,proteins
R8802 T11273 T11271 prep with,forming
R8803 T11274 T11275 det these,proteins
R8804 T11176 T11174 dobj proteins,regulate
R8805 T11275 T11273 pobj proteins,with
R8806 T11276 T11271 punct ",",forming
R8807 T11277 T11271 advcl making,forming
R8808 T11177 T11174 advmod differently,regulate
R8809 T11278 T11279 nsubj them,unable
R8810 T11279 T11277 ccomp unable,making
R8811 T11178 T11166 punct .,show
R8812 T11280 T11281 aux to,bind
R8813 T11281 T11279 xcomp bind,unable
R8814 T11282 T11281 dobj DNA,bind
R8815 T11179 T11183 nsubjpass Id2,considered
R8816 T11283 T11261 punct .,act
R8817 T11284 T11287 nsubjpass It,proposed
R8818 T11285 T11287 aux has,proposed
R8819 T11286 T11287 auxpass been,proposed
R8820 T11287 T11287 ROOT proposed,proposed
R8821 T11288 T11299 mark that,have
R8822 T11180 T11179 cc and,Id2
R8823 T11289 T11290 det the,balance
R8824 T11290 T11299 nsubj balance,have
R8825 T11291 T11290 prep among,balance
R8826 T11181 T11179 conj Id3,Id2
R8827 T11292 T11291 pobj E-proteins,among
R8828 T11293 T11292 punct ",",E-proteins
R8829 T11182 T11183 auxpass are,considered
R8830 T11294 T11292 conj Pax5,E-proteins
R8831 T11295 T11294 cc and,Pax5
R8832 T11183 T11183 ROOT considered,considered
R8833 T11296 T11297 compound Id,proteins
R8834 T11184 T11185 aux to,be
R8835 T11297 T11294 conj proteins,Pax5
R8836 T11298 T11299 aux might,have
R8837 T11185 T11183 xcomp be,considered
R8838 T11299 T11287 ccomp have,proposed
R8839 T11300 T11302 det an,role
R8840 T11186 T11188 det the,proteins
R8841 T11301 T11302 amod important,role
R8842 T11302 T11299 dobj role,have
R8843 T11303 T11302 prep in,role
R8844 T11187 T11188 compound Id,proteins
R8845 T11304 T11306 amod activated,cells
R8846 T11305 T11306 compound B,cells
R8847 T11188 T11185 attr proteins,be
R8848 T11306 T11303 pobj cells,in
R8849 T11307 T11309 nmod [,]
R8850 T11189 T11190 advmod mainly,expressed
R8851 T11190 T11188 acl expressed,proteins
R8852 T11308 T11309 nummod 38,]
R8853 T11191 T11190 prep in,expressed
R8854 T11309 T11306 appos ],cells
R8855 T11310 T11287 punct .,proposed
R8856 T11311 T11318 prep In,implicated
R8857 T11192 T11194 amod mature,cells
R8858 T11312 T11313 det that,respect
R8859 T11313 T11311 pobj respect,In
R8860 T11193 T11194 compound B,cells
R8861 T11314 T11318 punct ",",implicated
R8862 T11315 T11318 nsubjpass E-proteins,implicated
R8863 T11316 T11318 aux have,implicated
R8864 T11194 T11191 pobj cells,in
R8865 T11317 T11318 auxpass been,implicated
R8866 T11318 T11318 ROOT implicated,implicated
R8867 T11195 T11197 nmod [,]
R8868 T11196 T11197 nummod 38,]
R8869 T11319 T11318 prep in,implicated
R8870 T11320 T11322 preconj both,promotion
R8871 T11197 T11194 appos ],cells
R8872 T11321 T11322 det the,promotion
R8873 T11322 T11319 pobj promotion,in
R8874 T11323 T11322 cc and,promotion
R8875 T11198 T11183 punct .,considered
R8876 T11324 T11322 conj inhibition,promotion
R8877 T11325 T11324 prep of,inhibition
R8878 T11326 T11327 compound cell,survival
R8879 T11199 T11201 det The,study
R8880 T11327 T11325 pobj survival,of
R8881 T11328 T11327 cc and,survival
R8882 T11200 T11201 amod present,study
R8883 T11329 T11327 conj growth,survival
R8884 T11330 T11322 prep at,promotion
R8885 T11331 T11332 amod different,points
R8886 T11201 T11203 nsubj study,found
R8887 T11332 T11330 pobj points,at
R8888 T11333 T11322 prep in,promotion
R8889 T11202 T11203 advmod also,found
R8890 T11334 T11335 compound lymphocyte,development
R8891 T11335 T11333 pobj development,in
R8892 T11336 T11338 nmod [,]
R8893 T11203 T11203 ROOT found,found
R8894 T11337 T11338 nummod 40,]
R8895 T11338 T11322 appos ],promotion
R8896 T11339 T11318 punct .,implicated
R8897 T11204 T11203 dobj Id2,found
R8898 T11340 T11341 det The,antiproliferative
R8899 T11341 T11344 nsubj antiproliferative,inducing
R8900 T11205 T11204 cc and,Id2
R8901 T11342 T11341 cc and,antiproliferative
R8902 T11343 T11344 npadvmod death,inducing
R8903 T11344 T11357 csubj inducing,is
R8904 T11206 T11207 compound Id3,protein
R8905 T11345 T11344 dobj effect,inducing
R8906 T11346 T11345 prep of,effect
R8907 T11347 T11346 pobj BMP-6,of
R8908 T11207 T11204 conj protein,Id2
R8909 T11348 T11344 prep in,inducing
R8910 T11349 T11350 compound B,cells
R8911 T11350 T11348 pobj cells,in
R8912 T11208 T11203 prep in,found
R8913 T11351 T11344 prep with,inducing
R8914 T11352 T11353 amod concomitant,upregulation
R8915 T11353 T11351 pobj upregulation,with
R8916 T11354 T11353 prep of,upregulation
R8917 T11355 T11356 amod Id1,protein
R8918 T11209 T11210 compound B,cells
R8919 T11356 T11354 pobj protein,of
R8920 T11357 T11357 ROOT is,is
R8921 T11358 T11359 advmod therefore,in
R8922 T11210 T11208 pobj cells,in
R8923 T11359 T11357 prep in,is
R8924 T11360 T11359 pobj line,in
R8925 T11211 T11212 aux to,be
R8926 T11361 T11360 prep with,line
R8927 T11362 T11363 det the,view
R8928 T11363 T11361 pobj view,with
R8929 T11212 T11203 advcl be,found
R8930 T11364 T11368 mark that,required
R8931 T11365 T11368 prep Id,required
R8932 T11366 T11368 nsubjpass proteins,required
R8933 T11213 T11215 advmod more,expressed
R8934 T11367 T11368 auxpass are,required
R8935 T11368 T11363 acl required,view
R8936 T11369 T11368 prep for,required
R8937 T11214 T11215 advmod highly,expressed
R8938 T11370 T11371 det the,induction
R8939 T11371 T11369 pobj induction,for
R8940 T11372 T11371 prep of,induction
R8941 T11215 T11212 acomp expressed,be
R8942 T11373 T11374 compound growth,arrest
R8943 T11374 T11372 pobj arrest,of
R8944 T11216 T11215 prep than,expressed
R8945 T11375 T11374 cc and,arrest
R8946 T11376 T11374 conj apoptosis,arrest
R8947 T11217 T11216 pobj Id1,than
R8948 T11218 T11217 prep in,Id1
R8949 T11377 T11371 prep in,induction
R8950 T11219 T11218 pcomp resting,in
R8951 T11378 T11379 amod B-lymphocyte,progenitors
R8952 T11379 T11377 pobj progenitors,in
R8953 T11220 T11221 compound B,cells
R8954 T11380 T11371 prep by,induction
R8955 T11381 T11382 compound TGF-β,[
R8956 T11382 T11380 pobj [,by
R8957 T11221 T11219 dobj cells,resting
R8958 T11383 T11384 nummod 40,]
R8959 T11384 T11382 appos ],[
R8960 T11385 T11357 punct .,is
R8961 T11416 T11422 nsubjpass members,overexpressed
R8962 T11386 T11391 advmod Furthermore,known
R8963 T11417 T11416 prep of,members
R8964 T11387 T11391 punct ",",known
R8965 T11388 T11391 advmod Id,known
R8966 T11418 T11420 det the,family
R8967 T11389 T11391 nsubjpass proteins,known
R8968 T11390 T11391 auxpass are,known
R8969 T11391 T11391 ROOT known,known
R8970 T11392 T11391 prep as,known
R8971 T11393 T11394 amod important,parts
R8972 T11419 T11420 compound Id,family
R8973 T11394 T11392 pobj parts,as
R8974 T11395 T11394 prep of,parts
R8975 T11396 T11395 pcomp signalling,of
R8976 T11420 T11417 pobj family,of
R8977 T11397 T11396 dobj pathways,signalling
R8978 T11398 T11397 acl involved,pathways
R8979 T11399 T11398 prep in,involved
R8980 T11421 T11422 auxpass are,overexpressed
R8981 T11400 T11399 pobj development,in
R8982 T11401 T11400 punct ",",development
R8983 T11402 T11403 compound cell,cycle
R8984 T11422 T11413 ccomp overexpressed,established
R8985 T11403 T11400 conj cycle,development
R8986 T11404 T11403 cc and,cycle
R8987 T11405 T11406 compound tumorigenesis,[
R8988 T11423 T11422 prep in,overexpressed
R8989 T11406 T11406 ROOT [,[
R8990 T11407 T11408 nummod 32,]
R8991 T11408 T11391 dobj ],known
R8992 T11424 T11425 det a,range
R8993 T11409 T11391 punct .,known
R8994 T11410 T11413 nsubjpass It,established
R8995 T11425 T11423 pobj range,in
R8996 T11411 T11413 auxpass is,established
R8997 T11412 T11413 advmod well,established
R8998 T11413 T11413 ROOT established,established
R8999 T11426 T11425 prep of,range
R9000 T11414 T11422 mark that,overexpressed
R9001 T11415 T11416 amod various,members
R9002 T11427 T11428 amod human,tumours
R9003 T11428 T11426 pobj tumours,of
R9004 T11429 T11428 cc and,tumours
R9005 T11439 T11440 advmod most,widely
R9006 T11430 T11433 advmod generally,appears
R9007 T11440 T11441 advmod widely,overexpressed
R9008 T11441 T11435 attr overexpressed,be
R9009 T11442 T11441 prep in,overexpressed
R9010 T11443 T11444 det a,variety
R9011 T11431 T11433 punct ",",appears
R9012 T11444 T11442 pobj variety,in
R9013 T11432 T11433 nsubj Id1,appears
R9014 T11433 T11413 conj appears,established
R9015 T11445 T11444 prep of,variety
R9016 T11434 T11435 aux to,be
R9017 T11446 T11447 amod human,malignancies
R9018 T11447 T11445 pobj malignancies,of
R9019 T11448 T11450 nmod [,]
R9020 T11449 T11450 nummod 41,]
R9021 T11450 T11444 appos ],variety
R9022 T11435 T11433 xcomp be,appears
R9023 T11451 T11444 punct ",",variety
R9024 T11452 T11444 prep including,variety
R9025 T11453 T11455 amod multiple,[
R9026 T11436 T11438 det the,member
R9027 T11454 T11455 compound myeloma,[
R9028 T11455 T11452 pobj [,including
R9029 T11437 T11438 compound family,member
R9030 T11438 T11441 nsubj member,overexpressed
R9031 T11456 T11457 nummod "42,32",]
R9032 T11514 T11513 pobj Id1,of
R9033 T11457 T11455 acl ],[
R9034 T11458 T11433 punct .,appears
R9035 T11459 T11474 advmod Additionally,be
R9036 T11460 T11474 punct ",",be
R9037 T11515 T11512 prep to,expression
R9038 T11461 T11462 poss our,findings
R9039 T11462 T11474 nsubj findings,be
R9040 T11516 T11515 pobj B-lymphocytes,to
R9041 T11463 T11465 dobj that,activates
R9042 T11464 T11465 nsubj BMP-6,activates
R9043 T11517 T11507 ccomp resulted,is
R9044 T11465 T11462 relcl activates,findings
R9045 T11466 T11468 amod intracellular,pathways
R9046 T11467 T11468 amod signalling,pathways
R9047 T11518 T11517 prep in,resulted
R9048 T11468 T11465 dobj pathways,activates
R9049 T11469 T11468 prep in,pathways
R9050 T11470 T11472 amod human,cells
R9051 T11519 T11522 amod aberrant,development
R9052 T11471 T11472 compound B,cells
R9053 T11472 T11469 pobj cells,in
R9054 T11473 T11474 aux might,be
R9055 T11520 T11521 compound B,cell
R9056 T11474 T11474 ROOT be,be
R9057 T11475 T11474 prep of,be
R9058 T11476 T11478 amod potential,significance
R9059 T11521 T11522 compound cell,development
R9060 T11477 T11478 amod pathophysiological,significance
R9061 T11478 T11475 pobj significance,of
R9062 T11479 T11478 prep in,significance
R9063 T11522 T11518 pobj development,in
R9064 T11480 T11479 pobj lymphoma,in
R9065 T11481 T11480 cc and,lymphoma
R9066 T11523 T11522 punct ",",development
R9067 T11482 T11480 conj inflammation,lymphoma
R9068 T11483 T11474 punct .,be
R9069 T11484 T11486 compound High,mRNA
R9070 T11485 T11486 compound BMP-6,mRNA
R9071 T11486 T11487 compound mRNA,expression
R9072 T11487 T11492 nsubjpass expression,shown
R9073 T11524 T11525 amod massive,apoptosis
R9074 T11488 T11487 prep in,expression
R9075 T11489 T11488 pobj DLBCL,in
R9076 T11490 T11492 aux has,shown
R9077 T11491 T11492 auxpass been,shown
R9078 T11525 T11522 conj apoptosis,development
R9079 T11492 T11492 ROOT shown,shown
R9080 T11493 T11494 aux to,correlate
R9081 T11494 T11492 xcomp correlate,shown
R9082 T11526 T11517 punct ",",resulted
R9083 T11495 T11494 prep to,correlate
R9084 T11496 T11497 amod unfavourable,outcome
R9085 T11497 T11495 pobj outcome,to
R9086 T11527 T11517 cc and,resulted
R9087 T11498 T11500 nmod [,]
R9088 T11499 T11500 nummod 12,]
R9089 T11500 T11495 pobj ],to
R9090 T11528 T11529 amod subsequent,development
R9091 T11501 T11492 punct .,shown
R9092 T11502 T11507 prep In,is
R9093 T11503 T11504 det this,respect
R9094 T11529 T11536 nmod development,]
R9095 T11504 T11502 pobj respect,In
R9096 T11505 T11507 punct ",",is
R9097 T11506 T11507 nsubj it,is
R9098 T11530 T11529 prep of,development
R9099 T11507 T11507 ROOT is,is
R9100 T11508 T11507 prep of,is
R9101 T11509 T11508 pobj interest,of
R9102 T11531 T11532 compound B,cell
R9103 T11510 T11517 dobj that,resulted
R9104 T11511 T11512 amod targeted,expression
R9105 T11512 T11517 nsubj expression,resulted
R9106 T11532 T11533 compound cell,lymphomas
R9107 T11513 T11512 prep of,expression
R9108 T11533 T11530 pobj lymphomas,of
R9109 T11534 T11536 nmod [,]
R9110 T11613 T11609 xcomp elucidate,be
R9111 T11535 T11536 nummod 35,]
R9112 T11536 T11507 npadvmod ],is
R9113 T11614 T11615 det the,role
R9114 T11537 T11507 punct .,is
R9115 T11538 T11543 advmod Moreover,suggested
R9116 T11539 T11543 punct ",",suggested
R9117 T11540 T11543 nsubjpass BMP-6,suggested
R9118 T11541 T11543 aux has,suggested
R9119 T11542 T11543 auxpass been,suggested
R9120 T11615 T11613 dobj role,elucidate
R9121 T11543 T11543 ROOT suggested,suggested
R9122 T11616 T11615 prep of,role
R9123 T11617 T11616 pobj Id-1,of
R9124 T11618 T11617 prep in,Id-1
R9125 T11544 T11545 aux to,play
R9126 T11619 T11621 amod human,cells
R9127 T11545 T11543 xcomp play,suggested
R9128 T11620 T11621 compound B,cells
R9129 T11546 T11547 det a,role
R9130 T11547 T11545 dobj role,play
R9131 T11621 T11618 pobj cells,in
R9132 T11548 T11547 prep in,role
R9133 T11549 T11550 amod rheumatoid,arthritis
R9134 T11550 T11548 pobj arthritis,in
R9135 T11622 T11613 prep by,elucidate
R9136 T11551 T11552 punct (,RA
R9137 T11552 T11550 appos RA,arthritis
R9138 T11623 T11622 pobj selective,by
R9139 T11553 T11543 punct ),suggested
R9140 T11554 T11556 compound [,]
R9141 T11555 T11556 compound "43,44",]
R9142 T11556 T11566 nsubjpass ],found
R9143 T11624 T11623 prt over,selective
R9144 T11557 T11556 cc and,]
R9145 T11558 T11559 amod elevated,levels
R9146 T11559 T11556 conj levels,]
R9147 T11625 T11624 pobj expression,over
R9148 T11560 T11559 prep of,levels
R9149 T11561 T11560 pobj Id1,of
R9150 T11562 T11561 cc and,Id1
R9151 T11626 T11625 cc or,expression
R9152 T11563 T11561 conj Id3,Id1
R9153 T11564 T11566 aux have,found
R9154 T11627 T11625 conj inhibition,expression
R9155 T11565 T11566 auxpass been,found
R9156 T11566 T11566 ROOT found,found
R9157 T11567 T11566 prep in,found
R9158 T11628 T11625 prep of,expression
R9159 T11568 T11569 det the,synovia
R9160 T11569 T11567 pobj synovia,in
R9161 T11570 T11569 prep of,synovia
R9162 T11629 T11631 amod Id-1,expression
R9163 T11571 T11570 pobj RA-patients,of
R9164 T11572 T11574 quantmod [,]
R9165 T11573 T11574 nummod 45,]
R9166 T11630 T11631 compound gene,expression
R9167 T11574 T11569 appos ],synovia
R9168 T11575 T11566 punct .,found
R9169 T11576 T11580 advmod Altogether,point
R9170 T11577 T11580 punct ",",point
R9171 T11578 T11579 det these,results
R9172 T11579 T11580 nsubj results,point
R9173 T11631 T11628 pobj expression,of
R9174 T11580 T11580 ROOT point,point
R9175 T11581 T11580 prep to,point
R9176 T11582 T11584 det an,role
R9177 T11583 T11584 amod important,role
R9178 T11632 T11609 punct .,be
R9179 T11584 T11581 pobj role,to
R9180 T11585 T11584 prep for,role
R9181 T11633 T11643 prep Given,demonstrated
R9182 T11586 T11587 compound Id,proteins
R9183 T11587 T11585 pobj proteins,for
R9184 T11588 T11584 prep in,role
R9185 T11589 T11590 det the,regulation
R9186 T11634 T11635 det the,role
R9187 T11590 T11588 pobj regulation,in
R9188 T11591 T11590 prep of,regulation
R9189 T11592 T11595 amod normal,homeostasis
R9190 T11635 T11633 pobj role,Given
R9191 T11593 T11594 compound B,cell
R9192 T11594 T11595 compound cell,homeostasis
R9193 T11595 T11591 pobj homeostasis,of
R9194 T11596 T11588 cc and,in
R9195 T11636 T11635 prep of,role
R9196 T11597 T11588 conj in,in
R9197 T11598 T11597 pobj diseases,in
R9198 T11637 T11636 pobj BMP-6,of
R9199 T11599 T11598 punct ",",diseases
R9200 T11600 T11604 advmod where,involved
R9201 T11601 T11602 compound B,cells
R9202 T11602 T11604 nsubjpass cells,involved
R9203 T11638 T11635 prep in,role
R9204 T11603 T11604 auxpass are,involved
R9205 T11604 T11598 relcl involved,diseases
R9206 T11605 T11580 punct .,point
R9207 T11606 T11609 nsubj It,be
R9208 T11607 T11609 aux will,be
R9209 T11639 T11642 amod mature,cells
R9210 T11608 T11609 advmod therefore,be
R9211 T11640 T11642 amod human,cells
R9212 T11609 T11609 ROOT be,be
R9213 T11610 T11609 acomp important,be
R9214 T11641 T11642 compound B,cells
R9215 T11611 T11613 aux to,elucidate
R9216 T11612 T11613 advmod further,elucidate
R9217 T11642 T11638 pobj cells,in
R9218 T11643 T11643 ROOT demonstrated,demonstrated
R9219 T11644 T11643 advmod here,demonstrated
R9220 T11645 T11643 punct ",",demonstrated
R9221 T11646 T11664 nsubj identification,contribute
R9222 T11711 T11718 punct ",",reported
R9223 T11647 T11646 prep of,identification
R9224 T11712 T11715 det an,loop
R9225 T11713 T11715 amod autocrine,loop
R9226 T11648 T11649 nsubj BMP-6,producing
R9227 T11714 T11715 compound BMP-6,loop
R9228 T11715 T11718 nsubjpass loop,reported
R9229 T11649 T11647 pcomp producing,of
R9230 T11716 T11718 aux has,reported
R9231 T11717 T11718 auxpass been,reported
R9232 T11718 T11718 ROOT reported,reported
R9233 T11650 T11649 dobj cells,producing
R9234 T11719 T11718 agent by,reported
R9235 T11720 T11719 pobj others,by
R9236 T11721 T11720 prep in,others
R9237 T11651 T11649 prep in,producing
R9238 T11722 T11721 pobj chondrocytes,in
R9239 T11723 T11721 cc and,in
R9240 T11652 T11651 pobj vivo,in
R9241 T11724 T11721 conj in,in
R9242 T11725 T11726 det the,ovarium
R9243 T11726 T11724 pobj ovarium,in
R9244 T11653 T11649 prep with,producing
R9245 T11654 T11653 pobj possibility,with
R9246 T11655 T11654 prep of,possibility
R9247 T11727 T11729 compound [,]
R9248 T11656 T11655 pobj interaction,of
R9249 T11728 T11729 compound "46,19,18",]
R9250 T11729 T11720 appos ],others
R9251 T11657 T11656 prep with,interaction
R9252 T11730 T11718 punct .,reported
R9253 T11731 T11734 advmod Therefore,wanted
R9254 T11658 T11657 pobj naïve,with
R9255 T11732 T11734 punct ",",wanted
R9256 T11733 T11734 nsubj we,wanted
R9257 T11659 T11658 cc and,naïve
R9258 T11734 T11734 ROOT wanted,wanted
R9259 T11735 T11736 aux to,explore
R9260 T11736 T11734 xcomp explore,wanted
R9261 T11660 T11662 compound memory,cells
R9262 T11737 T11738 det the,possibility
R9263 T11738 T11736 dobj possibility,explore
R9264 T11739 T11738 prep for,possibility
R9265 T11661 T11662 compound B,cells
R9266 T11740 T11743 det an,loop
R9267 T11741 T11743 amod autocrine,loop
R9268 T11742 T11743 compound BMP-6,loop
R9269 T11743 T11739 pobj loop,for
R9270 T11744 T11743 prep in,loop
R9271 T11745 T11747 amod human,cells
R9272 T11662 T11658 conj cells,naïve
R9273 T11746 T11747 compound B,cells
R9274 T11747 T11744 pobj cells,in
R9275 T11748 T11734 punct .,wanted
R9276 T11749 T11750 nsubj We,analysed
R9277 T11663 T11664 aux might,contribute
R9278 T11750 T11750 ROOT analysed,analysed
R9279 T11751 T11752 det the,expression
R9280 T11752 T11750 dobj expression,analysed
R9281 T11664 T11643 ccomp contribute,demonstrated
R9282 T11753 T11754 compound BMP-6,mRNA
R9283 T11754 T11752 appos mRNA,expression
R9284 T11755 T11750 prep in,analysed
R9285 T11665 T11664 prep to,contribute
R9286 T11756 T11759 amod peripheral,cells
R9287 T11757 T11758 compound blood,B
R9288 T11758 T11759 compound B,cells
R9289 T11666 T11667 det the,understanding
R9290 T11759 T11755 pobj cells,in
R9291 T11760 T11750 prep by,analysed
R9292 T11761 T11762 amod real-time,PCR
R9293 T11762 T11760 pobj PCR,by
R9294 T11667 T11665 pobj understanding,to
R9295 T11763 T11750 punct ",",analysed
R9296 T11764 T11750 cc and,analysed
R9297 T11668 T11667 prep of,understanding
R9298 T11765 T11750 conj report,analysed
R9299 T11669 T11672 amod mature,biology
R9300 T11766 T11765 advmod here,report
R9301 T11670 T11671 compound B,cell
R9302 T11767 T11768 det the,upregulation
R9303 T11768 T11765 dobj upregulation,report
R9304 T11769 T11768 prep of,upregulation
R9305 T11671 T11672 compound cell,biology
R9306 T11770 T11772 amod endogenous,transcripts
R9307 T11771 T11772 compound BMP-6,transcripts
R9308 T11772 T11769 pobj transcripts,of
R9309 T11672 T11668 pobj biology,of
R9310 T11773 T11768 prep after,upregulation
R9311 T11774 T11773 pobj stimulation,after
R9312 T11775 T11768 prep with,upregulation
R9313 T11673 T11643 punct .,demonstrated
R9314 T11776 T11775 pobj FCS,with
R9315 T11777 T11768 punct ",",upregulation
R9316 T11674 T11676 compound High,mRNA
R9317 T11778 T11779 compound human,AB-serum
R9318 T11779 T11768 conj AB-serum,upregulation
R9319 T11780 T11779 cc and,AB-serum
R9320 T11781 T11785 punct ",",anti-IgM
R9321 T11782 T11783 advmod most,importantly
R9322 T11783 T11785 advmod importantly,anti-IgM
R9323 T11675 T11676 compound BMP-6,mRNA
R9324 T11784 T11785 punct ",",anti-IgM
R9325 T11785 T11779 conj anti-IgM,AB-serum
R9326 T11786 T11785 punct .,anti-IgM
R9327 T11676 T11677 compound mRNA,expression
R9328 T11787 T11796 advmod However,were
R9329 T11788 T11796 punct ",",were
R9330 T11789 T11790 poss our,attempts
R9331 T11790 T11796 nsubj attempts,were
R9332 T11677 T11682 nsubjpass expression,detected
R9333 T11791 T11792 aux to,study
R9334 T11792 T11790 acl study,attempts
R9335 T11793 T11795 compound BMP-6,levels
R9336 T11678 T11677 prep in,expression
R9337 T11794 T11795 compound protein,levels
R9338 T11795 T11792 dobj levels,study
R9339 T11796 T11796 ROOT were,were
R9340 T11679 T11678 pobj DLBCL,in
R9341 T11797 T11796 acomp unsuccessful,were
R9342 T11798 T11796 acomp due,were
R9343 T11799 T11798 prep to,due
R9344 T11680 T11682 aux has,detected
R9345 T11800 T11799 pobj problems,to
R9346 T11801 T11800 prep with,problems
R9347 T11802 T11803 amod unspecific,binding
R9348 T11803 T11801 pobj binding,with
R9349 T11681 T11682 auxpass been,detected
R9350 T11804 T11803 prep of,binding
R9351 T11805 T11807 det the,antibodies
R9352 T11806 T11807 amod anti-BMP-6,antibodies
R9353 T11682 T11682 ROOT detected,detected
R9354 T11807 T11804 pobj antibodies,of
R9355 T11808 T11803 conj tested,binding
R9356 T11809 T11808 punct ",",tested
R9357 T11683 T11682 agent by,detected
R9358 T11684 T11685 compound gene,expression
R9359 T11685 T11683 pobj expression,by
R9360 T11810 T11808 cc and,tested
R9361 T11811 T11801 pobj lack,with
R9362 T11686 T11685 acl profiling,expression
R9363 T11812 T11811 prep of,lack
R9364 T11813 T11814 amod specific,staining
R9365 T11687 T11689 nmod [,]
R9366 T11814 T11812 pobj staining,of
R9367 T11815 T11814 prep in,staining
R9368 T11816 T11817 compound control,cells
R9369 T11817 T11815 pobj cells,in
R9370 T11818 T11817 acl known,cells
R9371 T11688 T11689 nummod 12,]
R9372 T11819 T11820 aux to,express
R9373 T11820 T11818 xcomp express,known
R9374 T11821 T11822 compound BMP-6,mRNA
R9375 T11689 T11686 dobj ],profiling
R9376 T11822 T11820 dobj mRNA,express
R9377 T11823 T11796 punct .,were
R9378 T11690 T11682 punct .,detected
R9379 T11824 T11832 prep In,detected
R9380 T11825 T11824 pobj contrast,In
R9381 T11826 T11832 punct ",",detected
R9382 T11691 T11703 advmod Furthermore,detected
R9383 T11827 T11829 det the,protein
R9384 T11828 T11829 compound recombinant,protein
R9385 T11692 T11703 punct ",",detected
R9386 T11829 T11832 nsubjpass protein,detected
R9387 T11830 T11832 auxpass was,detected
R9388 T11831 T11832 advmod readily,detected
R9389 T11693 T11703 nsubjpass production,detected
R9390 T11832 T11832 ROOT detected,detected
R9391 T11833 T11832 punct .,detected
R9392 T11834 T11841 prep In,detected
R9393 T11694 T11693 prep of,production
R9394 T11835 T11836 det that,respect
R9395 T11836 T11834 pobj respect,In
R9396 T11837 T11841 punct ",",detected
R9397 T11695 T11696 compound BMP-6,transcripts
R9398 T11838 T11839 amod few,investigators
R9399 T11839 T11841 nsubj investigators,detected
R9400 T11840 T11841 aux have,detected
R9401 T11696 T11694 pobj transcripts,of
R9402 T11841 T11841 ROOT detected,detected
R9403 T11842 T11843 compound BMP-6,protein
R9404 T11843 T11841 dobj protein,detected
R9405 T11697 T11693 prep in,production
R9406 T11844 T11843 prep in,protein
R9407 T11698 T11701 amod normal,cells
R9408 T11699 T11701 amod activated,cells
R9409 T11845 T11844 pobj humans,in
R9410 T11846 T11844 punct ",",in
R9411 T11700 T11701 compound B,cells
R9412 T11847 T11848 advmod especially,in
R9413 T11848 T11844 conj in,in
R9414 T11849 T11850 amod non-pathogenic,tissue
R9415 T11701 T11697 pobj cells,in
R9416 T11850 T11848 pobj tissue,in
R9417 T11851 T11841 punct .,detected
R9418 T11852 T11853 det The,possibility
R9419 T11853 T11860 nsubj possibility,is
R9420 T11854 T11853 prep of,possibility
R9421 T11702 T11703 auxpass was,detected
R9422 T11855 T11856 compound BMP-6,production
R9423 T11856 T11854 pobj production,of
R9424 T11703 T11703 ROOT detected,detected
R9425 T11857 T11856 prep in,production
R9426 T11858 T11859 amod human,B-cells
R9427 T11859 T11857 pobj B-cells,in
R9428 T11860 T11860 ROOT is,is
R9429 T11704 T11703 prep in,detected
R9430 T11861 T11860 prep in,is
R9431 T11862 T11861 pobj line,in
R9432 T11705 T11707 det the,study
R9433 T11863 T11862 prep with,line
R9434 T11864 T11866 det a,work
R9435 T11865 T11866 amod recent,work
R9436 T11866 T11863 pobj work,with
R9437 T11706 T11707 amod same,study
R9438 T11867 T11868 nsubj that,reported
R9439 T11868 T11866 relcl reported,work
R9440 T11707 T11704 pobj study,in
R9441 T11869 T11870 det the,production
R9442 T11870 T11868 dobj production,reported
R9443 T11871 T11870 prep of,production
R9444 T11872 T11871 pobj BMP-6,of
R9445 T11708 T11703 punct .,detected
R9446 T11873 T11870 prep in,production
R9447 T11874 T11876 compound mouse,cells
R9448 T11709 T11718 prep Of,reported
R9449 T11875 T11876 compound B,cells
R9450 T11876 T11873 pobj cells,in
R9451 T11877 T11860 punct ",",is
R9452 T11878 T11860 advcl infiltrating,is
R9453 T11710 T11709 pobj note,Of
R9454 T11879 T11881 det the,marrow
R9455 T11880 T11881 compound bone,marrow
R9456 T11881 T11878 dobj marrow,infiltrating
R9457 T11907 T11906 punct .,suggested
R9458 T11882 T11881 prep of,marrow
R9459 T11883 T11882 pobj mice,of
R9460 T11884 T11881 prep with,marrow
R9461 T11885 T11886 amod inflammatory,arthritis
R9462 T11886 T11884 pobj arthritis,with
R9463 T11908 T11909 det The,upregulation
R9464 T11887 T11889 nmod [,]
R9465 T11888 T11889 nummod 43,]
R9466 T11909 T11915 nsubj upregulation,is
R9467 T11889 T11881 appos ],marrow
R9468 T11890 T11860 punct .,is
R9469 T11891 T11906 prep In,suggested
R9470 T11892 T11893 det this,study
R9471 T11893 T11891 pobj study,In
R9472 T11894 T11906 punct ",",suggested
R9473 T11910 T11909 prep of,upregulation
R9474 T11895 T11896 det a,role
R9475 T11896 T11906 nsubjpass role,suggested
R9476 T11897 T11896 prep for,role
R9477 T11911 T11912 det the,BMP-6-transcripts
R9478 T11898 T11897 pobj BMPs,for
R9479 T11899 T11898 prep in,BMPs
R9480 T11900 T11902 det the,process
R9481 T11912 T11910 pobj BMP-6-transcripts,of
R9482 T11901 T11902 amod inflammatoric,process
R9483 T11902 T11899 pobj process,in
R9484 T11903 T11902 prep of,process
R9485 T11913 T11909 prep after,upregulation
R9486 T11904 T11903 pobj arthritis,of
R9487 T11905 T11906 auxpass was,suggested
R9488 T11906 T11906 ROOT suggested,suggested
R9489 T11914 T11915 nsubj IgM-crosslinking,is
R9490 T11915 T11915 ROOT is,is
R9491 T11916 T11915 prep of,is
R9492 T11917 T11918 amod pathophysiologic,interest
R9493 T11918 T11916 pobj interest,of
R9494 T12004 T12013 mark that,define
R9495 T11919 T11921 nmod [,]
R9496 T12005 T12006 amod cellular,context
R9497 T12006 T12013 nsubj context,define
R9498 T11920 T11921 nummod 12,]
R9499 T11921 T11915 attr ],is
R9500 T12007 T12006 prep of,context
R9501 T11922 T11915 punct .,is
R9502 T12008 T12011 det the,cell
R9503 T12009 T12011 compound BMP,cell
R9504 T11923 T11924 det A,loss
R9505 T12010 T12011 compound target,cell
R9506 T12011 T12007 pobj cell,of
R9507 T12012 T12013 aux might,define
R9508 T11924 T11929 nsubjpass loss,suggested
R9509 T12013 T12003 ccomp define,indicating
R9510 T12014 T12017 det the,effects
R9511 T11925 T11924 prep of,loss
R9512 T11926 T11925 pobj TGF-β-responsiveness,of
R9513 T12015 T12017 amod various,effects
R9514 T12016 T12017 amod observed,effects
R9515 T12017 T12013 dobj effects,define
R9516 T11927 T11929 aux has,suggested
R9517 T12018 T11982 punct .,are
R9518 T12019 T12032 prep In,were
R9519 T12020 T12019 pobj contrast,In
R9520 T12021 T12020 prep to,contrast
R9521 T12022 T12023 det the,upregulation
R9522 T11928 T11929 auxpass been,suggested
R9523 T12023 T12021 pobj upregulation,to
R9524 T12024 T12023 prep of,upregulation
R9525 T12025 T12026 compound BMP-6,transcript
R9526 T12026 T12024 pobj transcript,of
R9527 T12027 T12023 prep in,upregulation
R9528 T12028 T12029 compound B,cells
R9529 T11929 T11929 ROOT suggested,suggested
R9530 T12029 T12027 pobj cells,in
R9531 T12030 T12032 punct ",",were
R9532 T12031 T12032 nsubj we,were
R9533 T11930 T11931 aux to,be
R9534 T12032 T12032 ROOT were,were
R9535 T12033 T12032 neg not,were
R9536 T12034 T12032 acomp able,were
R9537 T11931 T11929 xcomp be,suggested
R9538 T12035 T12036 aux to,detect
R9539 T12036 T12034 xcomp detect,able
R9540 T11932 T11934 det a,contribution
R9541 T12037 T12038 compound BMP-6,transcripts
R9542 T12038 T12036 dobj transcripts,detect
R9543 T12039 T12036 prep in,detect
R9544 T11933 T11934 amod critical,contribution
R9545 T12040 T12042 amod human,blood
R9546 T12041 T12042 amod peripheral,blood
R9547 T12042 T12043 compound blood,CD4
R9548 T12043 T12039 pobj CD4,in
R9549 T11934 T11931 attr contribution,be
R9550 T12044 T12043 nummod +,CD4
R9551 T12045 T12043 cc or,CD4
R9552 T12046 T12049 nummod CD8,cells
R9553 T11935 T11934 prep to,contribution
R9554 T12047 T12049 nummod +,cells
R9555 T12048 T12049 compound T,cells
R9556 T12049 T12043 conj cells,CD4
R9557 T11936 T11937 amod malignant,transformation
R9558 T12050 T12051 punct (,resting
R9559 T12051 T12043 acl resting,CD4
R9560 T11937 T11935 pobj transformation,to
R9561 T12052 T12051 cc or,resting
R9562 T12053 T12051 conj stimulated,resting
R9563 T12054 T12053 prep with,stimulated
R9564 T11938 T11940 nmod [,]
R9565 T12055 T12059 amod anti-CD3,data
R9566 T12056 T12055 cc and,anti-CD3
R9567 T12057 T12055 conj anti-CD28,anti-CD3
R9568 T12058 T12059 punct ;,data
R9569 T12059 T12054 pobj data,with
R9570 T12060 T12061 neg not,shown
R9571 T11939 T11940 nummod "47,48",]
R9572 T12061 T12059 acl shown,data
R9573 T12062 T12059 punct ),data
R9574 T12063 T12059 punct ",",data
R9575 T12064 T12059 amod consistent,data
R9576 T11940 T11944 nmod ],mechanisms
R9577 T12065 T12064 prep with,consistent
R9578 T12066 T12067 det the,findings
R9579 T12067 T12065 pobj findings,with
R9580 T11941 T11940 cc and,]
R9581 T12068 T12067 prep in,findings
R9582 T12069 T12070 compound T,cell
R9583 T12070 T12071 compound cell,lines
R9584 T11942 T11944 amod similar,mechanisms
R9585 T12071 T12068 pobj lines,in
R9586 T12072 T12074 nmod [,]
R9587 T11943 T11944 amod oncogenic,mechanisms
R9588 T12073 T12074 nummod 20,]
R9589 T12074 T12077 nmod ],cells
R9590 T12075 T12074 cc and,]
R9591 T11944 T11947 nsubjpass mechanisms,postulated
R9592 T12076 T12074 conj T,]
R9593 T12077 T12067 conj cells,findings
R9594 T12078 T12067 prep in,findings
R9595 T11945 T11947 aux have,postulated
R9596 T12079 T12078 pobj mice,in
R9597 T12080 T12082 nmod [,]
R9598 T12081 T12082 nummod 43,]
R9599 T11946 T11947 auxpass been,postulated
R9600 T11947 T11929 conj postulated,suggested
R9601 T12082 T12067 appos ],findings
R9602 T12083 T12032 punct .,were
R9603 T11948 T11947 prep for,postulated
R9604 T12084 T12087 amod Other,sources
R9605 T12085 T12087 amod potential,sources
R9606 T11949 T11948 pobj BMPs,for
R9607 T11950 T11947 punct .,postulated
R9608 T11951 T11954 nsubj Lines,suggest
R9609 T12086 T12087 compound BMP-6,sources
R9610 T12087 T12095 nsubj sources,be
R9611 T11952 T11951 prep of,Lines
R9612 T12088 T12087 prep for,sources
R9613 T12089 T12091 amod mature,cells
R9614 T12090 T12091 compound B,cells
R9615 T11953 T11952 pobj evidence,of
R9616 T12091 T12088 pobj cells,for
R9617 T12092 T12091 prep in,cells
R9618 T12093 T12092 pobj vivo,in
R9619 T12094 T12095 aux might,be
R9620 T12095 T12095 ROOT be,be
R9621 T11954 T11954 ROOT suggest,suggest
R9622 T12096 T12097 amod other,cells
R9623 T12097 T12095 attr cells,be
R9624 T11955 T11957 nsubj [,]
R9625 T12098 T12097 prep of,cells
R9626 T12099 T12101 det the,system
R9627 T11956 T11957 nummod 49,]
R9628 T12100 T12101 amod immune,system
R9629 T12101 T12098 pobj system,of
R9630 T11957 T11954 dobj ],suggest
R9631 T11958 T11966 mark that,is
R9632 T12102 T12101 cc or,system
R9633 T12103 T12101 conj tissue,system
R9634 T12104 T12103 prep with,tissue
R9635 T11959 T11966 prep at,is
R9636 T12105 T12104 pobj contact,with
R9637 T12106 T12105 prep to,contact
R9638 T11960 T11961 amod early,stages
R9639 T12107 T12109 det the,system
R9640 T12108 T12109 amod hematopoietic,system
R9641 T11961 T11959 pobj stages,at
R9642 T12109 T12106 pobj system,to
R9643 T12110 T12095 punct .,be
R9644 T11962 T11961 prep of,stages
R9645 T11963 T11962 pobj carcinogenesis,of
R9646 T11964 T11966 punct ",",is
R9647 T11965 T11966 nsubj BMP-6,is
R9648 T12111 T12114 nummod One,source
R9649 T12112 T12113 advmod well,recognized
R9650 T12113 T12114 amod recognized,source
R9651 T11966 T11957 relcl is,]
R9652 T12114 T12118 nsubj source,is
R9653 T12115 T12114 prep for,source
R9654 T11967 T11966 neg not,is
R9655 T12116 T12117 compound BMP-6,production
R9656 T12117 T12115 pobj production,for
R9657 T12118 T12118 ROOT is,is
R9658 T11968 T11970 det a,promoter
R9659 T12119 T12121 det the,bone
R9660 T12120 T12121 amod human,bone
R9661 T11969 T11970 compound tumour,promoter
R9662 T12121 T12118 attr bone,is
R9663 T12122 T12121 cc and,bone
R9664 T12123 T12124 compound bone,marrow
R9665 T11970 T11966 attr promoter,is
R9666 T12124 T12125 compound marrow,stroma
R9667 T12125 T12121 conj stroma,bone
R9668 T12126 T12128 compound [,]
R9669 T12127 T12128 compound "51,8",]
R9670 T12128 T12121 appos ],bone
R9671 T11971 T11954 punct ",",suggest
R9672 T12129 T12118 punct .,is
R9673 T12130 T12133 advmod Furthermore,is
R9674 T12131 T12133 punct ",",is
R9675 T12132 T12133 nsubj it,is
R9676 T11972 T11954 cc but,suggest
R9677 T12133 T12133 ROOT is,is
R9678 T12134 T12133 acomp noteworthy,is
R9679 T11973 T11954 conj suppresses,suggest
R9680 T12135 T12145 mark that,express
R9681 T12136 T12138 amod human,vein
R9682 T12137 T12138 amod umbilical,vein
R9683 T11974 T11978 amod benign,outgrowth
R9684 T12138 T12140 nmod vein,cells
R9685 T12139 T12140 amod endothelial,cells
R9686 T12140 T12145 nsubj cells,express
R9687 T11975 T11974 cc and,benign
R9688 T12141 T12140 punct (,cells
R9689 T12142 T12140 appos HUVEC,cells
R9690 T12143 T12140 punct ),cells
R9691 T11976 T11974 conj malignant,benign
R9692 T12144 T12145 advmod highly,express
R9693 T12145 T12133 ccomp express,is
R9694 T12146 T12148 compound BMP-6,[
R9695 T11977 T11978 compound tumour,outgrowth
R9696 T12147 T12148 compound mRNA,[
R9697 T12148 T12145 dobj [,express
R9698 T11978 T11973 dobj outgrowth,suppresses
R9699 T12149 T12150 nummod 52,]
R9700 T12150 T12148 conj ],[
R9701 T12151 T12150 punct ",",]
R9702 T12152 T12150 cc and,]
R9703 T11979 T11954 punct .,suggest
R9704 T12153 T12154 amod vascular,endothelium
R9705 T12154 T12150 conj endothelium,]
R9706 T12155 T12157 aux has,reported
R9707 T11980 T11981 det These,findings
R9708 T12156 T12157 auxpass been,reported
R9709 T12157 T12145 conj reported,express
R9710 T11981 T11982 nsubj findings,are
R9711 T12158 T12159 aux to,produce
R9712 T12159 T12157 xcomp produce,reported
R9713 T12160 T12161 compound BMP-6,[
R9714 T11982 T11982 ROOT are,are
R9715 T12161 T12159 dobj [,produce
R9716 T12162 T12163 nummod 53,]
R9717 T11983 T11982 prep in,are
R9718 T11984 T11985 amod good,agreement
R9719 T12163 T12161 appos ],[
R9720 T11985 T11983 pobj agreement,in
R9721 T12164 T12133 punct .,is
R9722 T11986 T11985 prep with,agreement
R9723 T12165 T12166 det These,studies
R9724 T12166 T12168 nsubj studies,imply
R9725 T12167 T12168 aux might,imply
R9726 T11987 T11988 amod previous,findings
R9727 T12168 T12168 ROOT imply,imply
R9728 T12169 T12170 det a,role
R9729 T12170 T12168 dobj role,imply
R9730 T11988 T11986 pobj findings,with
R9731 T12171 T12170 prep for,role
R9732 T12172 T12171 pobj BMP-6,for
R9733 T11989 T11985 prep for,agreement
R9734 T12173 T12170 prep in,role
R9735 T12174 T12175 amod transendothelial,migration
R9736 T12175 T12173 pobj migration,in
R9737 T11990 T11993 amod other,members
R9738 T12176 T12175 prep of,migration
R9739 T12177 T12178 compound B,cells
R9740 T12178 T12176 pobj cells,of
R9741 T11991 T11993 compound TGF-β,members
R9742 T12179 T12168 punct .,imply
R9743 T12180 T12184 npadvmod BMP-6,demonstrated
R9744 T11992 T11993 compound family,members
R9745 T12181 T12184 nsubjpass mRNA,demonstrated
R9746 T12182 T12184 aux has,demonstrated
R9747 T12183 T12184 auxpass been,demonstrated
R9748 T12184 T12184 ROOT demonstrated,demonstrated
R9749 T11993 T11989 pobj members,for
R9750 T12185 T12184 prep in,demonstrated
R9751 T12186 T12189 compound murine,lines
R9752 T11994 T11993 punct ",",members
R9753 T12187 T12189 compound macrophage,lines
R9754 T12188 T12189 compound cell,lines
R9755 T12189 T12185 pobj lines,in
R9756 T11995 T11993 prep including,members
R9757 T12190 T12184 punct ",",demonstrated
R9758 T12191 T12184 cc but,demonstrated
R9759 T12192 T12193 neg not,in
R9760 T11996 T11995 pobj TGF-β1,including
R9761 T12193 T12184 conj in,demonstrated
R9762 T12194 T12193 pobj humans,in
R9763 T12195 T12197 nmod [,]
R9764 T11997 T11996 cc and,TGF-β1
R9765 T12196 T12197 nummod 54,]
R9766 T12197 T12193 conj ],in
R9767 T12198 T12184 punct .,demonstrated
R9768 T11998 T11999 compound BMP-4,[
R9769 T12199 T12216 prep In,described
R9770 T11999 T11996 conj [,TGF-β1
R9771 T12200 T12199 pobj accordance,In
R9772 T12201 T12200 prep with,accordance
R9773 T12000 T12001 nummod 50,]
R9774 T12202 T12203 det these,findings
R9775 T12203 T12201 pobj findings,with
R9776 T12001 T11996 conj ],TGF-β1
R9777 T12204 T12216 punct ",",described
R9778 T12205 T12208 amod other,lines
R9779 T12206 T12208 amod human,lines
R9780 T12002 T11982 punct ",",are
R9781 T12003 T11982 advcl indicating,are
R9782 T12207 T12208 compound cell,lines
R9783 T12208 T12216 nsubjpass lines,described
R9784 T12209 T12208 prep of,lines
R9786 T12210 T12209 pobj neutrophil,of
R9787 T12211 T12210 cc and,neutrophil
R9788 T12212 T12213 amod monocytic,origin
R9789 T12213 T12210 conj origin,neutrophil
R9790 T12214 T12216 aux have,described
R9791 T12215 T12216 auxpass been,described
R9792 T12216 T12216 ROOT described,described
R9793 T12217 T12218 aux to,be
R9794 T12218 T12216 xcomp be,described
R9795 T12219 T12218 acomp negative,be
R9796 T12220 T12218 prep for,be
R9797 T12221 T12223 det the,transcript
R9798 T12222 T12223 compound BMP-6,transcript
R9799 T12223 T12220 pobj transcript,for
R9800 T12224 T12226 quantmod [,]
R9801 T12225 T12226 nummod 20,]
R9802 T12226 T12218 npadvmod ],be
R9803 T12227 T12216 punct .,described
R9804 T12228 T12233 prep To,is
R9805 T12229 T12230 poss our,knowledge
R9806 T12230 T12228 pobj knowledge,To
R9807 T12231 T12233 punct ",",is
R9808 T12232 T12233 expl there,is
R9809 T12233 T12233 ROOT is,is
R9810 T12234 T12233 advmod currently,is
R9811 T12235 T12236 det no,report
R9812 T12236 T12233 attr report,is
R9813 T12237 T12236 prep about,report
R9814 T12238 T12239 compound BMP-6,production
R9815 T12239 T12237 pobj production,about
R9816 T12240 T12239 prep of,production
R9817 T12241 T12243 amod human,cells
R9818 T12242 T12243 amod dendritic,cells
R9819 T12243 T12240 pobj cells,of
R9820 T12244 T12233 punct .,is
R10514 T13536 T13541 prep In,show
R10515 T13537 T13536 pobj conclusion,In
R10516 T13538 T13541 punct ",",show
R10517 T13539 T13540 poss our,results
R10518 T13540 T13541 nsubj results,show
R10519 T13541 T13541 ROOT show,show
R10520 T13542 T13544 mark that,induces
R10521 T13543 T13544 nsubj BMP-6,induces
R10522 T13544 T13541 ccomp induces,show
R10523 T13545 T13544 dobj activation,induces
R10524 T13546 T13545 prep of,activation
R10525 T13547 T13548 compound intracellular,Smad
R10526 T13548 T13549 compound Smad,signalling
R10527 T13549 T13546 pobj signalling,of
R10528 T13550 T13549 prep in,signalling
R10529 T13551 T13553 amod mature,B-cells
R10530 T13552 T13553 amod human,B-cells
R10531 T13553 T13550 pobj B-cells,in
R10532 T13554 T13553 prep with,B-cells
R10533 T13555 T13556 amod consecutive,production
R10534 T13556 T13554 pobj production,with
R10535 T13557 T13556 prep of,production
R10536 T13558 T13559 amod Id1,protein
R10537 T13559 T13557 pobj protein,of
R10538 T13560 T13541 punct .,show
R10539 T13561 T13564 advmod Furthermore,report
R10540 T13562 T13564 punct ",",report
R10541 T13563 T13564 nsubj we,report
R10542 T13564 T13564 ROOT report,report
R10543 T13565 T13567 mark that,has
R10544 T13566 T13567 nsubj BMP-6,has
R10545 T13567 T13564 ccomp has,report
R10546 T13568 T13570 det an,effect
R10547 T13569 T13570 amod antiproliferative,effect
R10548 T13570 T13567 dobj effect,has
R10549 T13571 T13570 prep in,effect
R10550 T13572 T13573 compound B,cells
R10551 T13573 T13571 pobj cells,in
R10552 T13574 T13573 acl stimulated,cells
R10553 T13575 T13574 prep with,stimulated
R10554 T13576 T13575 pobj anti-IgM,with
R10555 T13577 T13576 advmod alone,anti-IgM
R10556 T13578 T13576 cc or,anti-IgM
R10557 T13579 T13581 det the,action
R10558 T13580 T13581 amod combined,action
R10559 T13581 T13576 conj action,anti-IgM
R10560 T13582 T13581 prep of,action
R10561 T13583 T13582 pobj anti-IgM,of
R10562 T13584 T13583 cc and,anti-IgM
R10563 T13585 T13583 conj CD40L,anti-IgM
R10564 T13586 T13564 punct .,report
R10565 T13587 T13590 advmod Additionally,induces
R10566 T13588 T13590 punct ",",induces
R10567 T13589 T13590 nsubj BMP-6,induces
R10568 T13590 T13590 ROOT induces,induces
R10569 T13591 T13592 compound cell,death
R10570 T13592 T13590 dobj death,induces
R10571 T13593 T13590 prep in,induces
R10572 T13594 T13597 amod activated,cells
R10573 T13595 T13597 compound memory,cells
R10574 T13596 T13597 compound B,cells
R10575 T13597 T13593 pobj cells,in
R10576 T13598 T13597 cc and,cells
R10577 T13599 T13600 compound Ramos,cells
R10578 T13600 T13597 conj cells,cells
R10584 T13606 T13607 nsubj results,provide
R10585 T13607 T13607 ROOT provide,provide
R10586 T13608 T13609 det a,rationale
R10587 T13609 T13607 dobj rationale,provide
R10588 T13610 T13612 aux to,examine
R10589 T13611 T13612 advmod further,examine
R10590 T13612 T13607 advcl examine,provide
R10591 T13613 T13614 det the,role
R10592 T13614 T13612 dobj role,examine
R10593 T13615 T13614 prep of,role
R10594 T13616 T13615 pobj BMP-6,of
R10595 T13617 T13614 acl signalling,role
R10596 T13618 T13617 prep in,signalling
R10597 T13619 T13622 amod normal,biology
R10598 T13620 T13621 compound B,cell
R10599 T13621 T13622 compound cell,biology
R10600 T13622 T13618 pobj biology,in
R10601 T13623 T13625 advmod as,as
R10602 T13624 T13625 advmod well,as
R10603 T13625 T13618 cc as,in
R10604 T13626 T13618 conj in,in
R10605 T13627 T13628 amod pathologic,conditions
R10606 T13628 T13626 pobj conditions,in
R10607 T13629 T13628 prep like,conditions
R10608 T13630 T13631 compound B,cell
R10609 T13631 T13632 compound cell,malignancies
R10610 T13632 T13629 pobj malignancies,like
R10611 T13633 T13632 cc and,malignancies
R10612 T13634 T13635 amod autoimmune,disorders
R10613 T13635 T13632 conj disorders,malignancies
R10614 T13636 T13607 punct .,provide
R10828 T13907 T13908 compound Cell,culture
R10829 T13908 T13908 ROOT culture,culture
R10830 T13909 T13911 mark If,specified
R10831 T13910 T13911 neg not,specified
R10832 T13911 T13916 advcl specified,cultured
R10833 T13912 T13916 punct ",",cultured
R10834 T13913 T13914 det all,cells
R10835 T13914 T13916 nsubjpass cells,cultured
R10836 T13915 T13916 auxpass were,cultured
R10837 T13916 T13916 ROOT cultured,cultured
R10838 T13917 T13916 prep in,cultured
R10839 T13918 T13920 nmod X-VIVO,™
R10840 T13919 T13920 nummod 15,™
R10841 T13920 T13929 nmod ™,medium
R10842 T13921 T13922 punct (,BioWhittaker
R10843 T13922 T13920 appos BioWhittaker,™
R10844 T13923 T13922 punct ",",BioWhittaker
R10845 T13924 T13922 conj Verviers,BioWhittaker
R10846 T13925 T13924 punct ",",Verviers
R10847 T13926 T13924 conj Belgium,Verviers
R10848 T13927 T13922 punct ),BioWhittaker
R10849 T13928 T13929 amod serum-free,medium
R10850 T13929 T13916 dobj medium,cultured
R10851 T13930 T13916 prep at,cultured
R10852 T13931 T13932 nummod 37,°
R10853 T13932 T13933 nummod °,C
R10854 T13933 T13930 pobj C,at
R10855 T13934 T13916 cc and,cultured
R10856 T13935 T13936 nummod 5,%
R10857 T13936 T13916 conj %,cultured
R10858 T13937 T13936 nummod CO2,%
R10859 T13938 T13937 prep in,CO2
R10860 T13939 T13938 pobj air,in
R10861 T13940 T13937 punct .,CO2
R10862 T13941 T13942 amod Peripheral,blood
R10863 T13942 T13944 nsubjpass blood,provided
R10864 T13943 T13944 auxpass was,provided
R10865 T13944 T13944 ROOT provided,provided
R10866 T13945 T13944 agent by,provided
R10867 T13946 T13948 det the,Bank
R10868 T13947 T13948 compound Blood,Bank
R10869 T13948 T13945 pobj Bank,by
R10870 T13949 T13948 prep at,Bank
R10871 T13950 T13952 compound Buskerud,Hospital
R10872 T13951 T13952 compound Regional,Hospital
R10873 T13952 T13949 pobj Hospital,at
R10874 T13953 T13944 prep with,provided
R10875 T13954 T13955 amod formal,agreement
R10876 T13955 T13953 pobj agreement,with
R10877 T13956 T13955 prep by,agreement
R10878 T13957 T13958 det the,patients
R10879 T13958 T13956 pobj patients,by
R10880 T13959 T13944 punct ",",provided
R10881 T13960 T13944 cc and,provided
R10882 T13961 T13944 conj approval,provided
R10883 T13962 T13961 prep by,approval
R10884 T13963 T13966 det the,committee
R10885 T13964 T13966 amod regional,committee
R10886 T13965 T13966 compound ethics,committee
R10887 T13966 T13962 pobj committee,by
R10888 T13967 T13944 punct .,provided
R10889 T13968 T13969 nsubj Highly,purified
R10890 T13969 T13969 ROOT purified,purified
R10891 T13970 T13969 xcomp resting,purified
R10892 T13971 T13972 amod human,B-lymphocytes
R10893 T13972 T13970 dobj B-lymphocytes,resting
R10894 T13973 T13972 punct (,B-lymphocytes
R10895 T13974 T13976 nummod CD19,cells
R10896 T13975 T13976 compound +,cells
R10897 T13976 T13972 appos cells,B-lymphocytes
R10898 T13977 T13972 punct ),B-lymphocytes
R10899 T13978 T13979 auxpass were,isolated
R10900 T13979 T13969 conj isolated,purified
R10901 T13980 T13979 prep from,isolated
R10902 T13981 T13983 det the,blood
R10903 T13982 T13983 amod peripheral,blood
R10904 T13983 T13980 pobj blood,from
R10905 T13984 T13979 prep by,isolated
R10906 T13985 T13984 pcomp rosetting,by
R10907 T13986 T13985 prep with,rosetting
R10908 T13987 T13988 amod immunomagnetic,beads
R10909 T13988 T13986 pobj beads,with
R10910 T13989 T13991 punct (,M450
R10911 T13990 T13991 compound Dynabeads,M450
R10912 T13991 T13988 appos M450,beads
R10913 T13992 T13991 punct ;,M450
R10914 T13993 T13991 conj Dynal,M450
R10915 T13994 T13993 punct ",",Dynal
R10916 T13995 T13993 conj Oslo,Dynal
R10917 T13996 T13995 punct ",",Oslo
R10918 T13997 T13995 conj Norway,Oslo
R10919 T13998 T13988 punct ),beads
R10920 T13999 T14000 mark as,described
R10921 T14000 T13985 advcl described,rosetting
R10922 T14001 T14003 nmod [,]
R10923 T14002 T14003 nummod 55,]
R10924 T14003 T14000 dobj ],described
R10925 T14004 T13969 punct .,purified
R10926 T14005 T14006 det This,procedure
R10927 T14006 T14007 nsubj procedure,yields
R10928 T14007 T14007 ROOT yields,yields
R10929 T14008 T14010 amod less,0.5
R10930 T14009 T14010 quantmod than,0.5
R10931 T14010 T14011 nummod 0.5,%
R10932 T14011 T14013 compound %,cells
R10933 T14012 T14013 compound T,cells
R10934 T14013 T14007 dobj cells,yields
R10935 T14014 T14013 punct ",",cells
R10936 T14015 T14016 nummod 0.1,%
R10937 T14016 T14018 compound %,cells
R10938 T14017 T14018 compound NK,cells
R10939 T14018 T14013 conj cells,cells
R10940 T14019 T14018 punct ",",cells
R10941 T14020 T14018 cc and,cells
R10942 T14021 T14022 nummod 0.5,%
R10943 T14022 T14023 compound %,monocytes
R10944 T14023 T14018 conj monocytes,cells
R10945 T14024 T14025 mark as,judged
R10946 T14025 T14007 advcl judged,yields
R10947 T14026 T14025 agent by,judged
R10948 T14027 T14029 amod indirect,staining
R10949 T14028 T14029 compound immunofluorescence,staining
R10950 T14029 T14026 pobj staining,by
R10951 T14030 T14007 punct .,yields
R10952 T14031 T14034 det The,lines
R10953 T14032 T14034 amod following,lines
R10954 T14033 T14034 compound cell,lines
R10955 T14034 T14040 nsubjpass lines,maintained
R10956 T14035 T14034 prep from,lines
R10957 T14036 T14038 amod human,malignancies
R10958 T14037 T14038 amod lymphoid,malignancies
R10959 T14038 T14035 pobj malignancies,from
R10960 T14039 T14040 auxpass were,maintained
R10961 T14040 T14040 ROOT maintained,maintained
R10962 T14041 T14040 prep in,maintained
R10963 T14042 T14047 nmod RPMI,GmbH
R10964 T14043 T14042 nummod 1640,RPMI
R10965 T14044 T14047 punct (,GmbH
R10966 T14045 T14047 compound PAA,GmbH
R10967 T14046 T14047 compound Laboratories,GmbH
R10968 T14047 T14041 pobj GmbH,in
R10969 T14048 T14047 punct ",",GmbH
R10970 T14049 T14047 conj Pasching,GmbH
R10971 T14050 T14049 punct ",",Pasching
R10972 T14051 T14049 npadvmod Austria,Pasching
R10973 T14052 T14047 punct ),GmbH
R10974 T14053 T14040 conj supplemented,maintained
R10975 T14054 T14053 prep with,supplemented
R10976 T14055 T14056 nummod 10,%
R10977 T14056 T14059 nmod %,serum
R10978 T14057 T14059 amod foetal,serum
R10979 T14058 T14059 amod bovine,serum
R10980 T14059 T14054 pobj serum,with
R10981 T14060 T14059 punct (,serum
R10982 T14061 T14059 appos FCS,serum
R10983 T14062 T14059 punct ),serum
R10984 T14063 T14059 punct ",",serum
R10985 T14064 T14067 nummod 100,G
R10986 T14065 T14067 compound units/ml,G
R10987 T14066 T14067 compound penicillin,G
R10988 T14067 T14059 appos G,serum
R10989 T14068 T14059 punct ",",serum
R10990 T14069 T14059 cc and,serum
R10991 T14070 T14071 nummod 100,units/ml
R10992 T14071 T14059 conj units/ml,serum
R10993 T14072 T14071 prep of,units/ml
R10994 T14073 T14074 compound streptomycin,sulphate
R10995 T14074 T14072 pobj sulphate,of
R10996 T14075 T14071 punct ",",units/ml
R10997 T14076 T14071 cc but,units/ml
R10998 T14077 T14071 conj serum-starved,units/ml
R10999 T14078 T14077 prep for,serum-starved
R11000 T14079 T14080 advmod at,least
R11001 T14080 T14081 advmod least,four
R11002 T14081 T14082 nummod four,hours
R11003 T14082 T14078 pobj hours,for
R11004 T14083 T14077 cc and,serum-starved
R11005 T14084 T14077 conj cultured,serum-starved
R11006 T14085 T14084 prep in,cultured
R11007 T14086 T14088 nsubj X-VIVO,™
R11008 T14087 T14088 nummod 15,™
R11009 T14088 T14085 pobj ™,in
R11010 T14089 T14090 advmod when,included
R11011 T14090 T14053 advcl included,supplemented
R11012 T14091 T14090 prep in,included
R11013 T14092 T14091 pobj experiments,in
R11014 T14093 T14097 punct :,lines
R11015 T14094 T14097 amod EBV-negative,lines
R11016 T14095 T14097 compound BL,lines
R11017 T14096 T14097 compound cell,lines
R11018 T14097 T14098 compound lines,Ramos
R11019 T14098 T14040 npadvmod Ramos,maintained
R11020 T14099 T14100 punct (,ECACC
R11021 T14100 T14098 appos ECACC,Ramos
R11022 T14101 T14100 nummod 85030802,ECACC
R11023 T14102 T14098 punct ),Ramos
R11024 T14103 T14098 punct ",",Ramos
R11025 T14104 T14098 conj HL60,Ramos
R11026 T14105 T14104 punct (,HL60
R11027 T14106 T14104 appos JCRB0085,HL60
R11028 T14107 T14104 punct ),HL60
R11029 T14108 T14040 punct .,maintained
R11030 T14167 T14168 compound Growth,factors/supplements
R11031 T14168 T14168 ROOT factors/supplements,factors/supplements
R11032 T14169 T14171 det The,reagents
R11033 T14170 T14171 amod following,reagents
R11034 T14171 T14173 nsubjpass reagents,used
R11035 T14172 T14173 auxpass were,used
R11036 T14173 T14263 ccomp used,obtained
R11037 T14174 T14173 prep at,used
R11038 T14175 T14176 amod indicated,concentrations
R11039 T14176 T14174 pobj concentrations,at
R11040 T14177 T14176 punct :,concentrations
R11041 T14178 T14179 compound recombinant,human
R11042 T14179 T14176 appos human,concentrations
R11043 T14180 T14181 punct (,rhu
R11044 T14181 T14179 appos rhu,human
R11045 T14182 T14176 punct ),concentrations
R11046 T14183 T14230 nsubjpass BMP-6,purchased
R11047 T14184 T14188 punct (,ml
R11048 T14185 T14186 nummod 1,μg
R11049 T14186 T14188 compound μg,ml
R11050 T14187 T14188 compound /,ml
R11051 T14188 T14183 appos ml,BMP-6
R11052 T14189 T14188 punct ",",ml
R11053 T14190 T14192 mark if,specified
R11054 T14191 T14192 neg not,specified
R11055 T14192 T14183 advcl specified,BMP-6
R11056 T14193 T14192 advmod otherwise,specified
R11057 T14194 T14192 punct ),specified
R11058 T14195 T14183 punct ",",BMP-6
R11059 T14196 T14197 nmod rhu,BMP-RIB/ALK
R11060 T14197 T14201 nmod BMP-RIB/ALK,Chimera
R11061 T14198 T14199 compound -6,/
R11062 T14199 T14201 compound /,Chimera
R11063 T14200 T14201 compound Fc,Chimera
R11064 T14201 T14230 nsubjpass Chimera,purchased
R11065 T14202 T14206 punct (,ml
R11066 T14203 T14204 nummod 5,μg
R11067 T14204 T14206 compound μg,ml
R11068 T14205 T14206 compound /,ml
R11069 T14206 T14201 appos ml,Chimera
R11070 T14207 T14206 punct ),ml
R11071 T14208 T14201 punct ",",Chimera
R11072 T14209 T14211 compound rhu,Chimera
R11073 T14210 T14211 compound BMPR-II/Fc,Chimera
R11074 T14211 T14201 appos Chimera,Chimera
R11075 T14212 T14216 punct (,ml
R11076 T14213 T14214 nummod 5,μg
R11077 T14214 T14216 nmod μg,ml
R11078 T14215 T14216 compound /,ml
R11079 T14216 T14211 parataxis ml,Chimera
R11080 T14217 T14216 punct ),ml
R11081 T14218 T14211 punct ",",Chimera
R11082 T14219 T14211 cc and,Chimera
R11083 T14220 T14221 compound recombinant,mouse
R11084 T14221 T14222 compound mouse,Noggin
R11085 T14222 T14211 conj Noggin,Chimera
R11086 T14223 T14227 punct (,ml
R11087 T14224 T14225 nummod 5,μg
R11088 T14225 T14227 nmod μg,ml
R11089 T14226 T14227 compound /,ml
R11090 T14227 T14222 appos ml,Noggin
R11091 T14228 T14222 punct ),Noggin
R11092 T14229 T14230 auxpass were,purchased
R11093 T14230 T14173 conj purchased,used
R11094 T14231 T14230 prep from,purchased
R11095 T14232 T14233 compound R&D,Systems
R11096 T14233 T14231 pobj Systems,from
R11097 T14234 T14233 punct (,Systems
R11098 T14235 T14233 npadvmod Abingdon,Systems
R11099 T14236 T14235 punct ",",Abingdon
R11100 T14237 T14235 appos UK,Abingdon
R11101 T14238 T14233 punct ),Systems
R11102 T14239 T14263 punct ;,obtained
R11103 T14240 T14241 compound Anti-IgM,F
R11104 T14241 T14263 nsubjpass F,obtained
R11105 T14242 T14243 punct (,ab
R11106 T14243 T14241 appos ab,F
R11107 T14244 T14245 punct ),2
R11108 T14245 T14246 nummod 2,fragments
R11109 T14246 T14241 dobj fragments,F
R11110 T14247 T14246 prep of,fragments
R11111 T14248 T14250 compound rabbit,antibodies
R11112 T14249 T14250 compound polyclonal,antibodies
R11113 T14250 T14247 pobj antibodies,of
R11114 T14251 T14263 prep to,obtained
R11115 T14252 T14255 amod human,chain
R11116 T14253 T14255 compound IgM,chain
R11117 T14254 T14255 compound heavy,chain
R11118 T14255 T14251 pobj chain,to
R11119 T14256 T14255 punct (,chain
R11120 T14257 T14258 nummod 37.5,μg
R11121 T14258 T14260 nmod μg,ml
R11122 T14259 T14260 compound /,ml
R11123 T14260 T14255 appos ml,chain
R11124 T14261 T14260 punct ),ml
R11125 T14262 T14263 auxpass was,obtained
R11126 T14263 T14263 ROOT obtained,obtained
R11127 T14264 T14263 prep from,obtained
R11128 T14265 T14264 pobj Dako,from
R11129 T14266 T14265 punct ",",Dako
R11130 T14267 T14265 conj Copenhagen,Dako
R11131 T14268 T14267 punct ",",Copenhagen
R11132 T14269 T14267 conj Denmark,Copenhagen
R11133 T14270 T14269 cc and,Denmark
R11134 T14271 T14273 compound rhu,ligand
R11135 T14272 T14273 compound CD40,ligand
R11136 T14273 T14269 conj ligand,Denmark
R11137 T14274 T14275 punct (,CD40L
R11138 T14275 T14273 appos CD40L,ligand
R11139 T14276 T14275 punct ",",CD40L
R11140 T14277 T14278 nummod 10,ng/ml
R11141 T14278 T14275 appos ng/ml,CD40L
R11142 T14279 T14275 punct ),CD40L
R11143 T14280 T14263 auxpass was,obtained
R11144 T14281 T14282 det a,gift
R11145 T14282 T14263 dobj gift,obtained
R11146 T14283 T14263 prep from,obtained
R11147 T14284 T14285 compound Immunex,Corp.
R11148 T14285 T14283 pobj Corp.,from
R11149 T14286 T14285 punct (,Corp.
R11150 T14287 T14285 appos Seattle,Corp.
R11151 T14288 T14287 punct ",",Seattle
R11152 T14289 T14287 conj WA,Seattle
R11153 T14290 T14285 punct ),Corp.
R11154 T14291 T14263 punct .,obtained
R11398 T14718 T14719 nsubj Antibodies,used
R11399 T14719 T14719 ROOT used,used
R11400 T14720 T14719 prep for,used
R11401 T14721 T14720 pobj flow,for
R11402 T14722 T14723 amod cytometric,analysis
R11403 T14723 T14720 pobj analysis,for
R11404 T14724 T14723 cc and,analysis
R11405 T14725 T14727 compound immunoblot,Antibodies
R11406 T14726 T14727 compound analysis,Antibodies
R11407 T14727 T14723 conj Antibodies,analysis
R11408 T14728 T14723 prep against,analysis
R11409 T14729 T14732 det the,Act-RIA
R11410 T14730 T14731 amod human,BMP-receptors
R11411 T14731 T14732 compound BMP-receptors,Act-RIA
R11412 T14732 T14728 pobj Act-RIA,against
R11413 T14733 T14732 punct ",",Act-RIA
R11414 T14734 T14732 conj BMP-RIB,Act-RIA
R11415 T14735 T14734 punct ",",BMP-RIB
R11416 T14736 T14734 conj BMPR-II,BMP-RIB
R11417 T14737 T14736 punct ",",BMPR-II
R11418 T14738 T14736 conj Act-RIIA,BMPR-II
R11419 T14739 T14738 cc and,Act-RIIA
R11420 T14740 T14738 conj Act-RIIb,Act-RIIA
R11421 T14741 T14742 auxpass were,purchased
R11422 T14742 T14719 conj purchased,used
R11423 T14743 T14742 prep from,purchased
R11424 T14744 T14743 pobj R,from
R11425 T14745 T14744 cc &,R
R11426 T14746 T14747 compound D,Systems
R11427 T14747 T14744 conj Systems,R
R11428 T14748 T14747 punct (,Systems
R11429 T14749 T14747 npadvmod Abingdon,Systems
R11430 T14750 T14749 punct ",",Abingdon
R11431 T14751 T14749 appos UK,Abingdon
R11432 T14752 T14749 punct ),Abingdon
R11433 T14753 T14719 punct .,used
R11434 T14754 T14760 nsubjpass Detection,tried
R11435 T14755 T14754 prep of,Detection
R11436 T14756 T14757 det the,BMP-6-protein
R11437 T14757 T14755 pobj BMP-6-protein,of
R11438 T14758 T14760 aux has,tried
R11439 T14759 T14760 auxpass been,tried
R11440 T14760 T14766 ccomp tried,goat
R11441 T14761 T14760 prep with,tried
R11442 T14762 T14764 det the,antibodies
R11443 T14763 T14764 amod following,antibodies
R11444 T14764 T14761 pobj antibodies,with
R11445 T14765 T14766 punct :,goat
R11446 T14766 T14766 ROOT goat,goat
R11447 T14767 T14768 amod polyclonal,anti-BMP-6
R11448 T14768 T14766 dobj anti-BMP-6,goat
R11449 T14769 T14771 punct (,Cruz
R11450 T14770 T14771 compound Santa,Cruz
R11451 T14771 T14766 npadvmod Cruz,goat
R11452 T14772 T14771 punct ",",Cruz
R11453 T14773 T14774 compound San,Diego
R11454 T14774 T14771 npadvmod Diego,Cruz
R11455 T14775 T14774 punct ",",Diego
R11456 T14776 T14774 conj CA,Diego
R11457 T14777 T14776 punct ",",CA
R11458 T14778 T14776 conj USA,CA
R11459 T14779 T14776 punct ),CA
R11460 T14780 T14771 punct ",",Cruz
R11461 T14781 T14782 amod monoclonal,mouse
R11462 T14782 T14783 compound mouse,anti-BMP-6
R11463 T14783 T14771 appos anti-BMP-6,Cruz
R11464 T14784 T14783 cc and,anti-BMP-6
R11465 T14785 T14787 amod polyclonal,anti-BMP-6
R11466 T14786 T14787 compound goat,anti-BMP-6
R11467 T14787 T14783 conj anti-BMP-6,anti-BMP-6
R11468 T14788 T14787 prep from,anti-BMP-6
R11469 T14789 T14788 pobj R,from
R11470 T14790 T14789 cc &,R
R11471 T14791 T14792 compound D,Systems
R11472 T14792 T14789 conj Systems,R
R11473 T14793 T14792 punct (,Systems
R11474 T14794 T14792 npadvmod Abingdon,Systems
R11475 T14795 T14794 punct ",",Abingdon
R11476 T14796 T14794 appos UK,Abingdon
R11477 T14797 T14794 punct ),Abingdon
R11478 T14798 T14792 punct ",",Systems
R11479 T14799 T14787 cc and,anti-BMP-6
R11480 T14800 T14802 nmod mouse,anti-BMP-6
R11481 T14801 T14802 amod monoclonal,anti-BMP-6
R11482 T14802 T14787 conj anti-BMP-6,anti-BMP-6
R11483 T14803 T14806 punct (,Inc
R11484 T14804 T14806 compound Chemicon,Inc
R11485 T14805 T14806 compound International,Inc
R11486 T14806 T14771 appos Inc,Cruz
R11487 T14807 T14806 punct ",",Inc
R11488 T14808 T14806 conj Temecula,Inc
R11489 T14809 T14808 punct ",",Temecula
R11490 T14810 T14808 conj CA,Temecula
R11491 T14811 T14810 punct ",",CA
R11492 T14812 T14810 conj USA,CA
R11493 T14813 T14806 punct ),Inc
R11494 T14814 T14766 punct .,goat
R11495 T14815 T14820 nsubjpass Characterisation,done
R11496 T14816 T14815 prep of,Characterisation
R11497 T14817 T14818 amod BMP-signalling,pathways
R11498 T14818 T14816 pobj pathways,of
R11499 T14819 T14820 auxpass was,done
R11500 T14820 T14820 ROOT done,done
R11501 T14821 T14820 agent by,done
R11502 T14822 T14821 pobj use,by
R11503 T14823 T14822 prep of,use
R11504 T14824 T14823 pobj anti-phospho-Smad1,of
R11505 T14825 T14824 punct ",",anti-phospho-Smad1
R11506 T14826 T14824 nummod -5,anti-phospho-Smad1
R11507 T14827 T14824 punct ",",anti-phospho-Smad1
R11508 T14828 T14820 punct -,done
R11509 T14829 T14820 cc and,done
R11510 T14830 T14832 nummod 8,antibody
R11511 T14831 T14832 amod polyclonal,antibody
R11512 T14832 T14820 conj antibody,done
R11513 T14833 T14832 punct (,antibody
R11514 T14834 T14832 appos Chemicon,antibody
R11515 T14835 T14834 punct ",",Chemicon
R11516 T14836 T14834 conj Temecula,Chemicon
R11517 T14837 T14836 punct ",",Temecula
R11518 T14838 T14836 conj CA,Temecula
R11519 T14839 T14838 punct ",",CA
R11520 T14840 T14838 conj USA,CA
R11521 T14841 T14832 punct ),antibody
R11522 T14842 T14820 punct .,done
R11523 T14843 T14844 compound Expression,levels
R11524 T14844 T14850 nsubjpass levels,detected
R11525 T14845 T14844 prep of,levels
R11526 T14846 T14845 pobj Id1,of
R11527 T14847 T14848 nummod 3,proteins
R11528 T14848 T14850 nsubjpass proteins,detected
R11529 T14849 T14850 auxpass were,detected
R11530 T14850 T14850 ROOT detected,detected
R11531 T14851 T14850 prep with,detected
R11532 T14852 T14854 amod polyclonal,antibody
R11533 T14853 T14854 compound rabbit,antibody
R11534 T14854 T14851 pobj antibody,with
R11535 T14855 T14854 cc and,antibody
R11536 T14856 T14854 conj detection,antibody
R11537 T14857 T14858 auxpass was,blocked
R11538 T14858 T14850 conj blocked,detected
R11539 T14859 T14858 prep with,blocked
R11540 T14860 T14859 pcomp blocking,with
R11541 T14861 T14860 dobj peptide,blocking
R11542 T14862 T14860 prep from,blocking
R11543 T14863 T14865 compound Santa,Biotechnology
R11544 T14864 T14865 compound Cruz,Biotechnology
R11545 T14865 T14862 pobj Biotechnology,from
R11546 T14866 T14865 punct (,Biotechnology
R11547 T14867 T14868 compound Santa,Cruz
R11548 T14868 T14865 appos Cruz,Biotechnology
R11549 T14869 T14865 punct ",",Biotechnology
R11550 T14870 T14871 compound San,Diego
R11551 T14871 T14865 appos Diego,Biotechnology
R11552 T14872 T14865 punct ",",Biotechnology
R11553 T14873 T14865 appos CA,Biotechnology
R11554 T14874 T14873 punct ",",CA
R11555 T14875 T14865 appos USA,Biotechnology
R11556 T14876 T14865 punct ),Biotechnology
R11557 T14877 T14850 punct .,detected
R11558 T14878 T14881 mark As,served
R11559 T14879 T14880 amod secondary,antibodies
R11560 T14880 T14881 nsubj antibodies,served
R11561 T14881 T14881 ROOT served,served
R11562 T14882 T14887 acomp anti-mouse,IgG
R11563 T14883 T14882 punct ",",anti-mouse
R11564 T14884 T14882 conj anti-goat,anti-mouse
R11565 T14885 T14884 cc or,anti-goat
R11566 T14886 T14884 conj anti-rabbit,anti-goat
R11567 T14887 T14881 dobj IgG,served
R11568 T14888 T14887 punct -,IgG
R11569 T14889 T14890 compound horseradish,peroxidase
R11570 T14890 T14887 appos peroxidase,IgG
R11571 T14891 T14892 punct (,HRP
R11572 T14892 T14890 appos HRP,peroxidase
R11573 T14893 T14892 punct ),HRP
R11574 T14894 T14892 prep from,HRP
R11575 T14895 T14896 compound Dakocytomation,AS
R11576 T14896 T14894 pobj AS,from
R11577 T14897 T14896 punct (,AS
R11578 T14898 T14896 npadvmod Copenhagen,AS
R11579 T14899 T14898 punct ",",Copenhagen
R11580 T14900 T14898 appos Denmark,Copenhagen
R11581 T14901 T14896 punct ),AS
R11582 T14902 T14881 prep for,served
R11583 T14903 T14904 compound immunoblot,analysis
R11584 T14904 T14902 pobj analysis,for
R11585 T14905 T14881 punct .,served
R11586 T14906 T14907 nsubj Anti-β-actin,was
R11587 T14907 T14907 ROOT was,was
R11588 T14908 T14907 prep from,was
R11589 T14909 T14908 pobj Santa-Cruz,from
R11590 T14910 T14907 punct .,was
R11591 T14911 T14922 prep From,purchased
R11592 T14912 T14913 compound Becton,Dickinson
R11593 T14913 T14911 pobj Dickinson,From
R11594 T14914 T14913 punct (,Dickinson
R11595 T14915 T14916 compound San,Jose
R11596 T14916 T14913 appos Jose,Dickinson
R11597 T14917 T14916 punct ",",Jose
R11598 T14918 T14913 conj CA,Dickinson
R11599 T14919 T14913 punct ),Dickinson
R11600 T14920 T14922 punct ",",purchased
R11601 T14921 T14922 nsubj we,purchased
R11602 T14922 T14922 ROOT purchased,purchased
R11603 T14923 T14925 amod anti-CD19-PE,anti-CD19-FITC
R11604 T14924 T14925 punct ",",anti-CD19-FITC
R11605 T14925 T14922 dobj anti-CD19-FITC,purchased
R11606 T14926 T14922 punct .,purchased
R11607 T14927 T14928 det The,antibodies
R11608 T14928 T14933 nsubj antibodies,were
R11609 T14929 T14928 acl used,antibodies
R11610 T14930 T14929 prep for,used
R11611 T14931 T14930 pobj cell,for
R11612 T14932 T14928 acl sorting,antibodies
R11613 T14933 T14933 ROOT were,were
R11614 T14934 T14935 amod anti-CD19,PC5
R11615 T14935 T14933 attr PC5,were
R11616 T14936 T14935 prep from,PC5
R11617 T14937 T14938 compound Immunotech,SA
R11618 T14938 T14936 pobj SA,from
R11619 T14939 T14938 punct (,SA
R11620 T14940 T14938 npadvmod Marseille,SA
R11621 T14941 T14940 punct ",",Marseille
R11622 T14942 T14940 conj France,Marseille
R11623 T14943 T14942 punct ),France
R11624 T14944 T14938 cc and,SA
R11625 T14945 T14946 amod anti-CD27,PE
R11626 T14946 T14938 conj PE,SA
R11627 T14947 T14946 prep from,PE
R11628 T14948 T14949 compound Becton,Dickinson
R11629 T14949 T14947 pobj Dickinson,from
R11630 T14950 T14949 punct ",",Dickinson
R11631 T14951 T14952 compound Biosciences,Pharmingen
R11632 T14952 T14949 conj Pharmingen,Dickinson
R11633 T14953 T14955 punct (,Diego
R11634 T14954 T14955 compound San,Diego
R11635 T14955 T14949 appos Diego,Dickinson
R11636 T14956 T14955 punct ",",Diego
R11637 T14957 T14955 conj CA,Diego
R11638 T14958 T14957 punct ",",CA
R11639 T14959 T14957 conj USA,CA
R11699 T15151 T15154 nsubj Cell,purified
R11700 T15152 T15154 advcl sorting,purified
R11701 T15153 T15154 nsubj Highly,purified
R11702 T15154 T15154 ROOT purified,purified
R11703 T15155 T15166 nsubjpass CD19,obtained
R11704 T15156 T15166 npadvmod +,obtained
R11705 T15157 T15166 nsubjpass CD27,obtained
R11706 T15158 T15157 punct -,CD27
R11707 T15159 T15157 cc or,CD27
R11708 T15160 T15164 nummod CD19,cells
R11709 T15161 T15164 nummod +,cells
R11710 T15162 T15164 compound CD27,cells
R11711 T15163 T15164 compound +,cells
R11712 T15164 T15166 nsubjpass cells,obtained
R11713 T15165 T15166 auxpass were,obtained
R11714 T15166 T15154 ccomp obtained,purified
R11715 T15167 T15166 prep by,obtained
R11716 T15168 T15167 pcomp staining,by
R11717 T15169 T15168 dobj CD19,staining
R11718 T15170 T15171 nummod +,cells
R11719 T15171 T15169 appos cells,CD19
R11720 T15172 T15171 prep with,cells
R11721 T15173 T15174 amod anti-CD27,PE
R11722 T15174 T15172 pobj PE,with
R11723 T15175 T15174 cc and,PE
R11724 T15176 T15178 compound CD19,mAbs
R11725 T15177 T15178 compound PC5,mAbs
R11726 T15178 T15174 conj mAbs,PE
R11727 T15179 T15168 prep for,staining
R11728 T15180 T15181 nummod 30,minutes
R11729 T15181 T15179 pobj minutes,for
R11730 T15182 T15181 prep at,minutes
R11731 T15183 T15184 nummod 4,°
R11732 T15184 T15185 nummod °,C
R11733 T15185 T15182 pobj C,at
R11734 T15186 T15166 punct ",",obtained
R11735 T15187 T15166 advcl followed,obtained
R11736 T15188 T15187 prep by,followed
R11737 T15189 T15188 pcomp washing,by
R11738 T15190 T15189 prep with,washing
R11739 T15191 T15190 pobj PBS,with
R11740 T15192 T15189 cc and,washing
R11741 T15193 T15189 conj sorting,washing
R11742 T15194 T15193 prep on,sorting
R11743 T15195 T15196 compound FACS,DiVa
R11744 T15196 T15194 pobj DiVa,on
R11745 T15197 T15196 prep from,DiVa
R11746 T15198 T15199 compound Becton,Dickinson
R11747 T15199 T15197 pobj Dickinson,from
R11748 T15200 T15154 punct .,purified
R12228 T15878 T15888 nmod Analysis,expression
R12229 T15879 T15878 prep of,Analysis
R12230 T15880 T15882 amod BMP-6,RNA
R12231 T15881 T15882 compound messenger,RNA
R12232 T15882 T15879 pobj RNA,of
R12233 T15883 T15882 punct (,RNA
R12234 T15884 T15882 appos mRNA,RNA
R12235 T15885 T15882 punct ),RNA
R12236 T15886 T15888 nmod expression,expression
R12237 T15887 T15888 amod Endogenous,expression
R12238 T15888 T15894 nsubjpass expression,examined
R12239 T15889 T15888 prep of,expression
R12240 T15890 T15892 det the,gene
R12241 T15891 T15892 compound BMP-6,gene
R12242 T15892 T15889 pobj gene,of
R12243 T15893 T15894 auxpass was,examined
R12244 T15894 T15894 ROOT examined,examined
R12245 T15895 T15894 agent by,examined
R12246 T15896 T15899 amod reverse,reaction
R12247 T15897 T15899 compound transcription-polymerase,reaction
R12248 T15898 T15899 compound chain,reaction
R12249 T15899 T15895 pobj reaction,by
R12250 T15900 T15894 punct .,examined
R12251 T15901 T15902 amod Total,RNA
R12252 T15902 T15904 nsubjpass RNA,isolated
R12253 T15903 T15904 auxpass was,isolated
R12254 T15904 T15904 ROOT isolated,isolated
R12255 T15905 T15904 advcl using,isolated
R12256 T15906 T15907 advmod Absolutely,RNA
R12257 T15907 T15920 nmod RNA,according
R12258 T15908 T15911 nummod ™,Kit
R12259 T15909 T15911 compound RT-PCR,Kit
R12260 T15910 T15911 compound Miniprep,Kit
R12261 T15911 T15918 npadvmod Kit,Netherland
R12262 T15912 T15911 punct (,Kit
R12263 T15913 T15914 compound Stratagene,Europe
R12264 T15914 T15911 appos Europe,Kit
R12265 T15915 T15914 punct ",",Europe
R12266 T15916 T15914 conj Amsterdam,Europe
R12267 T15917 T15916 punct ",",Amsterdam
R12268 T15918 T15907 advmod Netherland,RNA
R12269 T15919 T15907 punct ),RNA
R12270 T15920 T15905 dobj according,using
R12271 T15921 T15920 prep to,according
R12272 T15922 T15924 det the,instructions
R12273 T15923 T15924 compound manufacturers,instructions
R12274 T15924 T15921 pobj instructions,to
R12275 T15925 T15904 punct .,isolated
R12276 T15926 T15933 nsubjpass Quantification,achieved
R12277 T15927 T15926 prep of,Quantification
R12278 T15928 T15931 det the,RNA
R12279 T15929 T15931 amod isolated,RNA
R12280 T15930 T15931 amod total,RNA
R12281 T15931 T15927 pobj RNA,of
R12282 T15932 T15933 auxpass was,achieved
R12283 T15933 T15933 ROOT achieved,achieved
R12284 T15934 T15933 prep by,achieved
R12285 T15935 T15934 pcomp using,by
R12286 T15936 T15937 compound spectrophotometric,OD260
R12287 T15937 T15938 compound OD260,measurements
R12288 T15938 T15935 dobj measurements,using
R12289 T15939 T15933 punct .,achieved
R12290 T15940 T15941 compound Equal,amounts
R12291 T15941 T15947 nsubjpass amounts,transcribed
R12292 T15942 T15941 prep of,amounts
R12293 T15943 T15942 pobj RNA,of
R12294 T15944 T15947 auxpass were,transcribed
R12295 T15945 T15946 advmod then,reverse
R12297 T15947 T15947 ROOT transcribed,transcribed
R12298 T15948 T15949 aux to,cDNA
R12299 T15949 T15947 advcl cDNA,transcribed
R12300 T15950 T15949 prep with,cDNA
R12301 T15951 T15952 compound TaqMan,®
R12302 T15952 T15950 pobj ®,with
R12303 T15953 T15953 ROOT Reverse,Reverse
R12304 T15954 T15955 compound Transcription,Reagents
R12305 T15955 T15953 dobj Reagents,Reverse
R12306 T15956 T15958 punct (,Biosystems
R12307 T15957 T15958 compound Applied,Biosystems
R12308 T15958 T15955 appos Biosystems,Reagents
R12309 T15959 T15958 punct ",",Biosystems
R12310 T15960 T15961 compound Foster,City
R12311 T15961 T15958 npadvmod City,Biosystems
R12312 T15962 T15961 punct ",",City
R12313 T15963 T15961 conj CA,City
R12314 T15964 T15963 punct ",",CA
R12315 T15965 T15963 conj U.S.A,CA
R12316 T15966 T15958 punct ),Biosystems
R12317 T15967 T15953 punct .,Reverse
R12318 T15968 T15969 aux To,measure
R12319 T15969 T15981 advcl measure,carried
R12320 T15970 T15971 compound mRNA,expression
R12321 T15971 T15981 nsubjpass expression,carried
R12322 T15972 T15971 prep of,expression
R12323 T15973 T15972 pobj BMP6,of
R12324 T15974 T15973 punct ",",BMP6
R12325 T15975 T15973 conj Id1,BMP6
R12326 T15976 T15971 appos Id4,expression
R12327 T15977 T15976 cc and,Id4
R12328 T15978 T15979 compound PGK1,PCR
R12329 T15979 T15976 conj PCR,Id4
R12330 T15980 T15981 auxpass were,carried
R12331 T15981 T15981 ROOT carried,carried
R12332 T15982 T15981 prt out,carried
R12333 T15983 T15981 prep with,carried
R12334 T15984 T15985 compound TaqMan,®
R12335 T15985 T15981 advcl ®,carried
R12336 T15986 T15988 amod universal,mix
R12337 T15987 T15988 compound master,mix
R12338 T15988 T15985 dobj mix,®
R12339 T15989 T15985 punct .,®
R12340 T15990 T15994 nsubjpass Primers,provided
R12341 T15991 T15990 cc and,Primers
R12342 T15992 T15990 conj probes,Primers
R12343 T15993 T15994 auxpass were,provided
R12344 T15994 T15994 ROOT provided,provided
R12345 T15995 T15994 agent by,provided
R12346 T15996 T15995 pobj Assay-on-Demand,by
R12347 T15997 T15999 punct (,Biosystems
R12348 T15998 T15999 compound Applied,Biosystems
R12349 T15999 T15996 parataxis Biosystems,Assay-on-Demand
R12350 T16000 T15999 punct ),Biosystems
R12351 T16001 T15994 punct .,provided
R12352 T16002 T16003 compound PCR,reactions
R12353 T16003 T16005 nsubjpass reactions,carried
R12354 T16004 T16005 auxpass were,carried
R12355 T16005 T16005 ROOT carried,carried
R12356 T16006 T16005 prt out,carried
R12357 T16007 T16005 prep in,carried
R12358 T16008 T16010 det a,volume
R12359 T16009 T16010 amod final,volume
R12360 T16010 T16007 pobj volume,in
R12361 T16011 T16010 prep of,volume
R12362 T16012 T16013 nummod 25,μl
R12363 T16013 T16011 pobj μl,of
R12364 T16014 T16015 punct (,BMP-6
R12365 T16015 T16013 appos BMP-6,μl
R12366 T16016 T16015 punct ),BMP-6
R12367 T16017 T16013 cc or,μl
R12368 T16018 T16019 nummod 20,μl
R12369 T16019 T16013 conj μl,μl
R12370 T16020 T16021 punct (,ID1
R12371 T16021 T16019 appos ID1,μl
R12372 T16022 T16019 punct ),μl
R12373 T16023 T16005 punct .,carried
R12374 T16024 T16025 det The,cDNA
R12375 T16025 T16026 nsubj cDNA,added
R12376 T16026 T16026 ROOT added,added
R12377 T16027 T16026 prep to,added
R12378 T16028 T16029 det each,reaction
R12379 T16029 T16027 pobj reaction,to
R12380 T16030 T16026 ccomp was,added
R12381 T16031 T16030 acomp equivalent,was
R12382 T16032 T16031 prep to,equivalent
R12383 T16033 T16034 det the,input
R12384 T16034 T16032 pobj input,to
R12385 T16035 T16034 prep of,input
R12386 T16036 T16037 nummod 20,ng
R12387 T16037 T16035 pobj ng,of
R12388 T16038 T16037 prep of,ng
R12389 T16039 T16040 amod total,RNA
R12390 T16040 T16038 pobj RNA,of
R12391 T16041 T16026 punct .,added
R12392 T16042 T16044 det The,expression
R12393 T16043 T16044 compound gene,expression
R12394 T16044 T16046 nsubjpass expression,quantified
R12395 T16045 T16046 auxpass was,quantified
R12396 T16046 T16046 ROOT quantified,quantified
R12397 T16047 T16046 advcl using,quantified
R12398 T16048 T16051 det the,method
R12399 T16049 T16051 amod standard,method
R12400 T16050 T16051 compound curve,method
R12401 T16051 T16047 dobj method,using
R12402 T16052 T16053 punct (,BMP6
R12403 T16053 T16051 appos BMP6,method
R12404 T16054 T16053 punct ),BMP6
R12405 T16055 T16051 punct ",",method
R12406 T16056 T16051 cc or,method
R12407 T16057 T16060 det the,method
R12408 T16058 T16060 amod comparative,method
R12409 T16059 T16060 compound CT,method
R12410 T16060 T16051 conj method,method
R12411 T16061 T16062 punct (,Id1
R12412 T16062 T16060 appos Id1,method
R12413 T16063 T16060 punct ),method
R12414 T16064 T16065 mark as,described
R12415 T16065 T16046 advcl described,quantified
R12416 T16066 T16065 prep in,described
R12417 T16067 T16069 compound ABI7700,Bulletin
R12418 T16068 T16069 compound User,Bulletin
R12419 T16069 T16066 pobj Bulletin,in
R12420 T16070 T16069 nummod 2,Bulletin
R12421 T16071 T16073 punct (,Biosystems
R12422 T16072 T16073 compound Applied,Biosystems
R12423 T16073 T16069 appos Biosystems,Bulletin
R12424 T16074 T16073 punct ),Biosystems
R12425 T16075 T16046 punct .,quantified
R12426 T16076 T16077 det The,expression
R12427 T16077 T16078 nsubj expression,was
R12428 T16078 T16078 ROOT was,was
R12429 T16079 T16080 advmod then,normalized
R12430 T16080 T16078 acomp normalized,was
R12431 T16081 T16080 prep to,normalized
R12432 T16082 T16084 det the,level
R12433 T16083 T16084 compound expression,level
R12434 T16084 T16081 pobj level,to
R12435 T16085 T16084 prep of,level
R12436 T16086 T16085 pobj PGK1,of
R12437 T16087 T16078 punct .,was
R12438 T16088 T16090 nsubjpass PGK1,chosen
R12439 T16089 T16090 auxpass was,chosen
R12440 T16090 T16090 ROOT chosen,chosen
R12441 T16091 T16090 punct ",",chosen
R12442 T16092 T16096 mark because,shown
R12443 T16093 T16096 nsubjpass it,shown
R12444 T16094 T16096 aux has,shown
R12445 T16095 T16096 auxpass been,shown
R12446 T16096 T16090 advcl shown,chosen
R12447 T16097 T16098 aux to,have
R12448 T16098 T16096 xcomp have,shown
R12449 T16099 T16101 amod low,variability
R12450 T16100 T16101 compound expression,variability
R12451 T16101 T16098 dobj variability,have
R12452 T16102 T16101 prep among,variability
R12453 T16103 T16104 amod lymphocyte,specimens
R12454 T16104 T16102 pobj specimens,among
R12455 T16105 T16107 nmod [,]
R12456 T16106 T16107 nummod 56,]
R12457 T16107 T16101 appos ],variability
R12458 T16108 T16090 punct .,chosen
R12459 T16109 T16110 compound Expression,levels
R12460 T16110 T16116 nsubjpass levels,related
R12461 T16111 T16110 prep in,levels
R12462 T16112 T16113 compound B,cells
R12463 T16113 T16111 pobj cells,in
R12464 T16114 T16116 auxpass were,related
R12465 T16115 T16116 advmod then,related
R12466 T16116 T16116 ROOT related,related
R12467 T16117 T16116 prep to,related
R12468 T16118 T16120 det the,levels
R12469 T16119 T16120 compound expression,levels
R12470 T16120 T16117 pobj levels,to
R12471 T16121 T16120 prep in,levels
R12472 T16122 T16123 compound Ramos,cells
R12473 T16123 T16121 pobj cells,in
R12474 T16124 T16116 punct .,related
R12633 T16348 T16349 compound Cell,proliferation
R12634 T16349 T16379 nsubjpass proliferation,cultured
R12635 T16350 T16379 prep For,cultured
R12636 T16351 T16350 pobj estimation,For
R12637 T16352 T16351 prep of,estimation
R12638 T16353 T16354 compound DNA,synthesis
R12639 T16354 T16352 pobj synthesis,of
R12640 T16355 T16379 punct ",",cultured
R12641 T16356 T16358 nmod CD19,cells
R12642 T16357 T16358 compound +,cells
R12643 T16358 T16379 nsubjpass cells,cultured
R12644 T16359 T16358 punct (,cells
R12645 T16360 T16361 nummod 7.5,×
R12646 T16361 T16358 appos ×,cells
R12647 T16362 T16364 nummod 104,.2
R12648 T16363 T16364 nummod cells/0,.2
R12649 T16364 T16365 nummod .2,ml
R12650 T16365 T16361 appos ml,×
R12651 T16366 T16361 punct ),×
R12652 T16367 T16361 cc or,×
R12653 T16368 T16369 compound Ramos,cells
R12654 T16369 T16358 appos cells,cells
R12655 T16370 T16371 punct (,1
R12656 T16371 T16374 nummod 1,cells/0
R12657 T16372 T16374 nummod ×,cells/0
R12658 T16373 T16374 nummod 104,cells/0
R12659 T16374 T16377 nmod cells/0,)
R12660 T16375 T16376 nummod .2,ml
R12661 T16376 T16374 appos ml,cells/0
R12662 T16377 T16358 punct ),cells
R12663 T16378 T16379 auxpass were,cultured
R12664 T16379 T16379 ROOT cultured,cultured
R12665 T16380 T16379 prep in,cultured
R12666 T16381 T16380 pobj triplicate,in
R12667 T16382 T16379 prep in,cultured
R12668 T16383 T16384 compound microtiter,wells
R12669 T16384 T16382 pobj wells,in
R12670 T16385 T16379 punct .,cultured
R12671 T16386 T16387 det The,cells
R12672 T16387 T16389 nsubjpass cells,pulsed
R12673 T16388 T16389 auxpass were,pulsed
R12674 T16389 T16389 ROOT pulsed,pulsed
R12675 T16390 T16389 prep with,pulsed
R12676 T16391 T16397 nummod 3.7,thymidine
R12677 T16392 T16397 nummod ×,thymidine
R12678 T16393 T16396 compound 104Bq,]
R12679 T16394 T16396 compound [,]
R12680 T16395 T16396 compound 3H,]
R12681 T16396 T16397 compound ],thymidine
R12682 T16397 T16390 pobj thymidine,with
R12683 T16398 T16399 punct (,Amersham
R12684 T16399 T16397 appos Amersham,thymidine
R12685 T16400 T16399 punct ",",Amersham
R12686 T16401 T16399 conj Buckinghamshire,Amersham
R12687 T16402 T16401 punct ",",Buckinghamshire
R12688 T16403 T16401 conj UK,Buckinghamshire
R12689 T16404 T16389 punct ),pulsed
R12690 T16405 T16389 prep for,pulsed
R12691 T16406 T16409 det the,h
R12692 T16407 T16409 amod last,h
R12693 T16408 T16409 nummod 16,h
R12694 T16409 T16405 pobj h,for
R12695 T16410 T16409 prep of,h
R12696 T16411 T16413 det a,incubation
R12697 T16412 T16413 amod 72-h,incubation
R12698 T16413 T16410 pobj incubation,of
R12699 T16414 T16389 punct .,pulsed
R12700 T16415 T16416 det The,cells
R12701 T16416 T16418 nsubjpass cells,harvested
R12702 T16417 T16418 auxpass were,harvested
R12703 T16418 T16418 ROOT harvested,harvested
R12704 T16419 T16418 advcl using,harvested
R12705 T16420 T16423 det an,harvester
R12706 T16421 T16423 amod automated,harvester
R12707 T16422 T16423 compound cell,harvester
R12708 T16423 T16419 dobj harvester,using
R12709 T16424 T16427 punct (,Company
R12710 T16425 T16427 compound Packard,Company
R12711 T16426 T16427 compound Instrument,Company
R12712 T16427 T16423 appos Company,harvester
R12713 T16428 T16427 punct ",",Company
R12714 T16429 T16427 conj Meriden,Company
R12715 T16430 T16429 punct ",",Meriden
R12716 T16431 T16429 conj CT,Meriden
R12717 T16432 T16431 punct ",",CT
R12718 T16433 T16431 conj USA,CT
R12719 T16434 T16433 punct ),USA
R12720 T16435 T16431 cc and,CT
R12721 T16436 T16440 compound [,incorporation
R12722 T16437 T16438 compound 3H,]
R12723 T16438 T16440 compound ],incorporation
R12724 T16439 T16440 compound thymidine,incorporation
R12725 T16440 T16442 nsubjpass incorporation,determined
R12726 T16441 T16442 auxpass was,determined
R12727 T16442 T16418 parataxis determined,harvested
R12728 T16443 T16442 prep in,determined
R12729 T16444 T16446 det a,counter
R12730 T16445 T16446 compound scintillation,counter
R12731 T16446 T16443 pobj counter,in
R12732 T16447 T16448 punct (,TopCount
R12733 T16448 T16446 appos TopCount,counter
R12734 T16449 T16448 punct ",",TopCount
R12735 T16450 T16453 compound Packard,Inc.
R12736 T16451 T16453 compound Instrument,Inc.
R12737 T16452 T16453 compound Company,Inc.
R12738 T16453 T16448 conj Inc.,TopCount
R12739 T16454 T16453 punct ",",Inc.
R12740 T16455 T16453 npadvmod Meriden,Inc.
R12741 T16456 T16455 punct ",",Meriden
R12742 T16457 T16455 appos CT,Meriden
R12743 T16458 T16455 punct ),Meriden
R12744 T16459 T16442 punct .,determined
R12801 T16540 T16547 nsubjpass Determination,measured
R12802 T16541 T16540 prep of,Determination
R12803 T16542 T16543 compound cell,death
R12804 T16543 T16545 compound death,death
R12805 T16544 T16545 compound Cell,death
R12806 T16545 T16541 pobj death,of
R12807 T16546 T16547 auxpass was,measured
R12808 T16547 T16547 ROOT measured,measured
R12809 T16548 T16547 agent by,measured
R12810 T16549 T16552 amod vital,test
R12811 T16550 T16551 compound dye,exclusion
R12812 T16551 T16552 compound exclusion,test
R12813 T16552 T16548 pobj test,by
R12814 T16553 T16547 prep by,measured
R12815 T16554 T16553 pcomp staining,by
R12816 T16555 T16554 dobj cells,staining
R12817 T16556 T16554 prep with,staining
R12818 T16557 T16558 nummod 5,μg
R12819 T16558 T16562 nmod μg,iodide
R12820 T16559 T16562 nmod /,iodide
R12821 T16560 T16562 nmod ml,iodide
R12822 T16561 T16562 compound propidium,iodide
R12823 T16562 T16556 pobj iodide,with
R12824 T16563 T16562 punct (,iodide
R12825 T16564 T16566 compound [,]
R12826 T16565 T16566 compound PI,]
R12827 T16566 T16562 appos ],iodide
R12828 T16567 T16562 punct ;,iodide
R12829 T16568 T16569 compound Calbiochem,Corp.
R12830 T16569 T16562 conj Corp.,iodide
R12831 T16570 T16569 punct ;,Corp.
R12832 T16571 T16572 compound La,Jolla
R12833 T16572 T16569 npadvmod Jolla,Corp.
R12834 T16573 T16572 punct ",",Jolla
R12835 T16574 T16572 conj CA,Jolla
R12836 T16575 T16572 punct ;,Jolla
R12837 T16576 T16577 nummod 5,mg/ml
R12838 T16577 T16569 appos mg/ml,Corp.
R12839 T16578 T16569 punct ),Corp.
R12840 T16579 T16554 prep for,staining
R12841 T16580 T16581 nummod one,minute
R12842 T16581 T16579 pobj minute,for
R12843 T16582 T16581 prep on,minute
R12844 T16583 T16582 pobj ice,on
R12845 T16584 T16547 punct .,measured
R12846 T16585 T16586 advmod At,least
R12847 T16586 T16587 advmod least,"1,000"
R12848 T16587 T16588 nummod "1,000",cells
R12849 T16588 T16592 nsubjpass cells,run
R12850 T16589 T16588 prep per,cells
R12851 T16590 T16589 pobj sample,per
R12852 T16591 T16592 auxpass were,run
R12853 T16592 T16592 ROOT run,run
R12854 T16593 T16592 prep on,run
R12855 T16594 T16597 det a,flow
R12856 T16595 T16597 compound BD,flow
R12857 T16596 T16597 compound FACSCalibur,flow
R12858 T16597 T16593 pobj flow,on
R12859 T16598 T16592 npadvmod cytometer,run
R12860 T16599 T16592 punct .,run
R12903 T16653 T16654 compound Statistical,analysis
R12904 T16654 T16663 nsubjpass analysis,determined
R12905 T16655 T16657 det The,significance
R12906 T16656 T16657 amod statistical,significance
R12907 T16657 T16663 nsubjpass significance,determined
R1537 T1947 T1944 cc and,-4
R1538 T1948 T1944 conj -7,-4
R295 T502 T503 nsubj BMP-6,inhibits
R296 T503 T503 ROOT inhibits,inhibits
R297 T504 T503 dobj growth,inhibits
R298 T505 T504 prep of,growth
R463 T670 T668 conj CD40L,anti-IgM
R464 T671 T633 punct .,found
R465 T672 T675 advmod Additionally,induced
R466 T673 T675 punct ",",induced
R467 T674 T675 nsubj BMP-6,induced
R468 T675 T675 ROOT induced,induced
R469 T676 T677 compound cell,death
R470 T677 T675 dobj death,induced
R471 T678 T675 prep in,induced
R472 T679 T682 amod activated,cells
R473 T680 T682 compound memory,cells
R474 T681 T682 compound B,cells
R475 T682 T678 pobj cells,in
R476 T683 T675 punct .,induced
R477 T684 T695 advmod Importantly,neutralized
R478 T685 T695 punct ",",neutralized
R479 T686 T688 det the,effect
R525 T732 T726 conj induced,inhibited
R526 T733 T732 dobj phosphorylation,induced
R527 T734 T733 prep of,phosphorylation
R528 T735 T736 amod Smad1/5/8,followed
R529 T736 T734 pcomp followed,of
R530 T737 T736 agent by,followed
R531 T738 T739 det an,upregulation
R532 T739 T737 pobj upregulation,by
R533 T740 T739 prep of,upregulation
R534 T741 T740 pobj Id1,of
R535 T742 T726 punct .,inhibited
R1320 T1730 T1741 nsubj Members,play
R1321 T1731 T1730 prep of,Members
R1322 T1732 T1735 det the,factor
R1323 T1733 T1735 amod transforming,factor
R1324 T1734 T1735 compound growth,factor
R1325 T1735 T1731 pobj factor,of
R1338 T1748 T1747 punct ",",proliferation
R1339 T1749 T1747 conj differentiation,proliferation
R1340 T1750 T1749 punct ",",differentiation
R1341 T1751 T1749 conj migration,differentiation
R1342 T1752 T1751 cc and,migration
R1343 T1753 T1754 compound apoptosis,[
R1344 T1754 T1751 conj [,migration
R1345 T1755 T1756 nummod 1,]
R1346 T1756 T1754 appos ],[
R1347 T1757 T1741 punct .,play
R1348 T1758 T1759 det These,cytokines
R1349 T1759 T1762 nsubjpass cytokines,divided
R1350 T1760 T1762 aux can,divided
R1351 T1761 T1762 auxpass be,divided
R1403 T1813 T1814 compound "2,3",]
R1404 T1814 T1806 dobj ],induce
R1405 T1815 T1791 punct .,are
R1406 T1816 T1817 amod Several,studies
R1407 T1817 T1819 nsubj studies,demonstrated
R1408 T1818 T1819 aux have,demonstrated
R1409 T1819 T1819 ROOT demonstrated,demonstrated
R1410 T1820 T1822 det an,role
R1411 T1821 T1822 amod essential,role
R1412 T1822 T1819 dobj role,demonstrated
R1413 T1823 T1822 prep of,role
R1414 T1824 T1825 det these,proteins
R1415 T1825 T1823 pobj proteins,of
R1706 T2109 T2111 advmod where,exert
R1707 T2110 T2111 nsubj they,exert
R1716 T2119 T2121 det the,role
R1717 T2120 T2121 amod reported,role
R1718 T2121 T2118 pobj role,Given
R1719 T2122 T2121 prep of,role
R1720 T2123 T2122 pobj BMP-6,of
R1721 T2124 T2121 prep in,role
R1722 T2125 T2126 compound B-cell,malignancies
R4591 T5872 T5873 amod transcriptional,changes
R12296 T15946 T15947 advmod reverse,transcribed
R12908 T16658 T16657 prep of,significance
R12909 T16659 T16658 pobj differences,of
R12910 T16660 T16659 prep between,differences
R12911 T16661 T16660 pobj groups,between
R12912 T16662 T16663 auxpass was,determined
R12913 T16663 T16663 ROOT determined,determined
R12914 T16664 T16663 advcl using,determined
R12915 T16665 T16670 det the,test
R12916 T16666 T16670 amod paired,test
R12917 T16667 T16670 amod two-tailed,test
R12918 T16668 T16670 nmod Wilcoxon,test
R12919 T16669 T16670 compound nonparametric,test
R12920 T16670 T16664 dobj test,using
R12921 T16671 T16663 punct ",",determined
R12922 T16672 T16663 prep by,determined
R12923 T16673 T16672 pcomp applying,by
R12924 T16674 T16676 nmod SPSS10,software
R12925 T16675 T16676 nummod .1,software
R12926 T16676 T16673 dobj software,applying
R12927 T16677 T16676 punct (,software
R12928 T16678 T16679 compound SPSS,Inc.
R12929 T16679 T16676 appos Inc.,software
R12930 T16680 T16679 punct ",",Inc.
R12931 T16681 T16679 npadvmod Chicago,Inc.
R12932 T16682 T16679 punct ",",Inc.
R12933 T16683 T16679 appos IL,Inc.
R12934 T16684 T16679 punct ",",Inc.
R12935 T16685 T16679 appos USA,Inc.
R12936 T16686 T16679 punct ),Inc.
R12937 T16687 T16663 punct .,determined
R12938 T16688 T16689 nsubj P,values
R12939 T16689 T16689 ROOT values,values
R12940 T16690 T16692 amod less,0.05
R12941 T16691 T16692 quantmod than,0.05
R12942 T16692 T16694 nsubjpass 0.05,considered
R12943 T16693 T16694 auxpass were,considered
R12944 T16694 T16689 ccomp considered,values
R12945 T16695 T16694 oprd significant,considered
R12946 T16696 T16689 punct .,values

UBERON-AE

Id Subject Object Predicate Lexical cue
T103 473-478 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T1030 1483-1490 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
T102 306-319 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T1031 2029-2036 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T1032 2242-2255 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T1033 3233-3236 http://purl.obolibrary.org/obo/UBERON_0002228 denotes RIB
T2601 4292-4297 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T2602 5143-5146 http://purl.obolibrary.org/obo/UBERON_0002228 denotes RIB
T2603 5390-5395 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T4029 6837-6840 http://purl.obolibrary.org/obo/UBERON_0002228 denotes RIB
T4030 7002-7005 http://purl.obolibrary.org/obo/UBERON_0002228 denotes RIB
T4557 7670-7675 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T13697 22949-22954 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T7561 21532-21538 http://purl.obolibrary.org/obo/UBERON_0003891 denotes stroma
T7562 21588-21602 http://purl.obolibrary.org/obo/UBERON_0002066 denotes umbilical vein
T7563 21588-21614 http://purl.obolibrary.org/obo/UBERON_0007777 denotes umbilical vein endothelial
T7564 21598-21602 http://purl.obolibrary.org/obo/UBERON_0001638 denotes vein
T7565 21674-21685 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T13694 22893-22898 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T13695 23593-23598 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T13696 23680-23685 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T13698 23194-23199 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T14138 24010-24013 http://purl.obolibrary.org/obo/UBERON_0002228 denotes RIB
T14382 24512-24515 http://purl.obolibrary.org/obo/UBERON_0002228 denotes RIB
T15250 25999-26004 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T16605 29375-29381 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tailed
T6458 11038-11043 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T7548 11856-11861 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T7549 19470-19475 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T7550 21127-21132 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T7551 12612-12615 http://purl.obolibrary.org/obo/UBERON_0002228 denotes RIB
T7552 13764-13767 http://purl.obolibrary.org/obo/UBERON_0002228 denotes RIB
T7553 12950-12955 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T7554 19604-19609 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T7555 20028-20034 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T7556 21401-21407 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T7557 20192-20203 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
T7558 21520-21531 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
T7559 21384-21397 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T7560 21428-21448 http://purl.obolibrary.org/obo/UBERON_0002390 denotes hematopoietic system

GO-BP

Id Subject Object Predicate Lexical cue
T174 15-21 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T175 1308-1314 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T176 65-80 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T177 590-605 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T178 638-653 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T179 1336-1351 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T180 65-97 http://purl.obolibrary.org/obo/GO_0042327 denotes phosphorylation and upregulation
T181 127-154 http://purl.obolibrary.org/obo/GO_0038055 denotes Bone morphogenetic proteins
T182 857-863 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T183 1014-1020 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T184 990-1000 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T185 990-1013 http://purl.obolibrary.org/obo/GO_1901216 denotes cell death in activated
T186 990-1013 http://purl.obolibrary.org/obo/GO_0071888 denotes cell death in activated
T187 990-1013 http://purl.obolibrary.org/obo/GO_0043068 denotes cell death in activated
T188 990-1013 http://purl.obolibrary.org/obo/GO_1904094 denotes cell death in activated
T189 995-1000 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T190 1303-1314 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T1061 1981-1994 http://purl.obolibrary.org/obo/GO_0009792 denotes embryogenesis
T1062 1981-1994 http://purl.obolibrary.org/obo/GO_0009793 denotes embryogenesis
T1063 2412-2428 http://purl.obolibrary.org/obo/GO_0048468 denotes cell development
T1064 2417-2428 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T1065 2691-2706 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T1066 2923-2930 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T1067 3093-3099 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T1068 3155-3161 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T1069 3860-3870 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T1070 3313-3328 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T1071 3499-3509 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T1072 3895-3905 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T1073 3860-3878 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathway
T2638 4358-4368 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T2639 4425-4447 http://purl.obolibrary.org/obo/GO_0002358 denotes proliferation, B-cells
T2640 4425-4447 http://purl.obolibrary.org/obo/GO_0042100 denotes proliferation, B-cells
T2641 4425-4447 http://purl.obolibrary.org/obo/GO_0030888 denotes proliferation, B-cells
T2642 4636-4649 http://purl.obolibrary.org/obo/GO_0071897 denotes DNA synthesis
T2643 4959-4972 http://purl.obolibrary.org/obo/GO_0071897 denotes DNA synthesis
T2644 5568-5581 http://purl.obolibrary.org/obo/GO_0071897 denotes DNA synthesis
T2645 5654-5667 http://purl.obolibrary.org/obo/GO_0071897 denotes DNA-synthesis
T2646 4640-4649 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T2647 4963-4972 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T2648 5572-5581 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T2649 5658-5667 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T2650 5293-5299 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T2651 5332-5338 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T2652 5743-5749 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T3584 5786-5796 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T3585 6116-6126 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T3586 6257-6267 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T3587 6348-6358 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T3588 5791-5796 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T3589 6121-6126 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T3590 6262-6267 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T3591 6353-6358 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T3592 5806-5812 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T3593 6190-6196 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T4609 7324-7339 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4610 7540-7555 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4611 7941-7956 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4612 7984-7999 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4613 8119-8134 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4614 7471-7477 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T4615 7611-7621 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T4616 8257-8267 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T4617 7540-7574 http://purl.obolibrary.org/obo/GO_0042327 denotes phosphorylation, as the activation
T4618 7611-7629 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathway
T4619 8257-8276 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T4620 8257-8283 http://purl.obolibrary.org/obo/GO_0030513 denotes signalling pathways of BMP
T4621 8257-8283 http://purl.obolibrary.org/obo/GO_0030514 denotes signalling pathways of BMP
T4622 8257-8283 http://purl.obolibrary.org/obo/GO_0030510 denotes signalling pathways of BMP
T4623 8257-8283 http://purl.obolibrary.org/obo/GO_0030509 denotes signalling pathways of BMP
T4624 8425-8428 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T5456 8567-8582 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T5457 8615-8630 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T5458 8778-8788 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T5459 9027-9029 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T5460 9152-9162 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T6491 10669-10671 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T6492 10757-10767 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T7880 11905-11915 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T7881 11910-11915 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T7882 17176-17181 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T7883 11925-11931 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T7884 18943-18949 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T7885 12061-12076 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7886 12114-12129 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7887 14149-14164 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7888 14279-14294 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7889 14377-14392 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7890 14412-14427 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7891 14682-14697 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7892 14778-14793 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7893 14885-14900 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7894 15155-15170 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7895 13030-13039 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T7896 13304-13313 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T7897 13510-13519 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T7898 17367-17376 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T7899 18228-18237 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T7900 13030-13039 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T7901 13304-13313 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T7902 13510-13519 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T7903 17367-17376 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T7904 18228-18237 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T7905 13385-13408 http://purl.obolibrary.org/obo/GO_0033080 denotes thymocyte proliferation
T7906 13478-13488 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T7907 15247-15257 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T7908 18542-18552 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T7909 13823-13829 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T7910 13919-13929 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T7911 13985-13995 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T7912 14480-14490 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T7913 15015-15025 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T7914 15202-15212 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T7915 15322-15332 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T7916 16067-16077 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T7917 17477-17487 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T7918 17880-17890 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T7919 13985-14003 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathway
T7920 14480-14499 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T7921 15015-15034 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T7922 17477-17496 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T7923 17880-17899 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T7924 14396-14399 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T7925 14431-14434 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T7926 14717-14720 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T7927 14476-14499 http://purl.obolibrary.org/obo/GO_0030513 denotes BMP-signalling pathways
T7928 14476-14499 http://purl.obolibrary.org/obo/GO_0030514 denotes BMP-signalling pathways
T7929 14476-14499 http://purl.obolibrary.org/obo/GO_0030510 denotes BMP-signalling pathways
T7930 14476-14499 http://purl.obolibrary.org/obo/GO_0030509 denotes BMP-signalling pathways
T7931 14480-14513 http://purl.obolibrary.org/obo/GO_0007229 denotes signalling pathways that mediated
T7932 14480-14513 http://purl.obolibrary.org/obo/GO_0019221 denotes signalling pathways that mediated
T7933 14480-14513 http://purl.obolibrary.org/obo/GO_0009755 denotes signalling pathways that mediated
T7934 14480-14513 http://purl.obolibrary.org/obo/GO_0038007 denotes signalling pathways that mediated
T7935 14480-14513 http://purl.obolibrary.org/obo/GO_0038161 denotes signalling pathways that mediated
T7936 14480-14513 http://purl.obolibrary.org/obo/GO_0038166 denotes signalling pathways that mediated
T7937 14480-14513 http://purl.obolibrary.org/obo/GO_0035689 denotes signalling pathways that mediated
T7938 14480-14513 http://purl.obolibrary.org/obo/GO_0070098 denotes signalling pathways that mediated
T7939 14480-14513 http://purl.obolibrary.org/obo/GO_0071847 denotes signalling pathways that mediated
T7940 15015-15045 http://purl.obolibrary.org/obo/GO_0031929 denotes signalling pathways and target
T7941 15371-15373 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T7942 15853-15869 http://purl.obolibrary.org/obo/GO_0048468 denotes cell development
T7943 18202-18218 http://purl.obolibrary.org/obo/GO_0048468 denotes cell development
T7944 15858-15869 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T7945 17132-17143 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T7946 17509-17520 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T7947 18207-18218 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T7948 18254-18265 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T7949 17091-17097 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T7950 17349-17355 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T7951 17121-17143 http://purl.obolibrary.org/obo/GO_0030098 denotes lymphocyte development
T7952 17367-17392 http://purl.obolibrary.org/obo/GO_0001783 denotes apoptosis in B-lymphocyte
T7953 17367-17392 http://purl.obolibrary.org/obo/GO_0002901 denotes apoptosis in B-lymphocyte
T7954 17522-17532 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T7955 17856-17899 http://purl.obolibrary.org/obo/GO_1902533 denotes activates intracellular signalling pathways
T7956 17866-17899 http://purl.obolibrary.org/obo/GO_0030522 denotes intracellular signalling pathways
T7957 17866-17899 http://purl.obolibrary.org/obo/GO_0035556 denotes intracellular signalling pathways
T7958 17866-17899 http://purl.obolibrary.org/obo/GO_1902532 denotes intracellular signalling pathways
T7959 17866-17899 http://purl.obolibrary.org/obo/GO_1902531 denotes intracellular signalling pathways
T7960 17987-17999 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T7961 18570-18581 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T7962 18764-18779 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T7963 19079-19094 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T7964 20915-20923 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T13404 22253-22263 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T13405 22657-22667 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T13406 22514-22524 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T13407 22514-22537 http://purl.obolibrary.org/obo/GO_1901216 denotes cell death in activated
T13408 22514-22537 http://purl.obolibrary.org/obo/GO_0071888 denotes cell death in activated
T13409 22514-22537 http://purl.obolibrary.org/obo/GO_0043068 denotes cell death in activated
T13410 22514-22537 http://purl.obolibrary.org/obo/GO_1904094 denotes cell death in activated
T13411 22519-22524 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T13412 22538-22544 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T13706 23203-23212 http://purl.obolibrary.org/obo/GO_0020013 denotes rosetting
T13707 23666-23674 http://purl.obolibrary.org/obo/GO_0051923 denotes sulphate
T14148 23844-23850 http://purl.obolibrary.org/obo/GO_0040007 denotes Growth
T14415 24726-24728 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T14416 24901-24903 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T14417 25046-25048 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T14418 25240-25242 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T14419 25489-25491 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T14420 25707-25709 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T14421 24931-24954 http://purl.obolibrary.org/obo/GO_0030513 denotes BMP-signalling pathways
T14422 24931-24954 http://purl.obolibrary.org/obo/GO_0030514 denotes BMP-signalling pathways
T14423 24931-24954 http://purl.obolibrary.org/obo/GO_0030510 denotes BMP-signalling pathways
T14424 24931-24954 http://purl.obolibrary.org/obo/GO_0030509 denotes BMP-signalling pathways
T14425 24935-24945 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T14426 24935-24954 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T14427 25372-25374 http://purl.obolibrary.org/obo/GO_0004066 denotes AS
T15263 26042-26047 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T15264 26135-26143 http://purl.obolibrary.org/obo/GO_0051923 denotes sulphate
T15265 26501-26503 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T15266 26684-26686 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T15267 26688-26703 http://purl.obolibrary.org/obo/GO_0003824 denotes Enzyme activity
T15268 26925-26927 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T15601 27201-27222 http://purl.obolibrary.org/obo/GO_0001171 denotes reverse transcription
T15602 27577-27598 http://purl.obolibrary.org/obo/GO_0001171 denotes Reverse Transcription
T15603 27209-27222 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T15604 27585-27598 http://purl.obolibrary.org/obo/GO_0006351 denotes Transcription
T15605 27295-27297 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T15606 27642-27644 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T15607 28006-28021 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T16234 28442-28460 http://purl.obolibrary.org/obo/GO_0008283 denotes Cell proliferation
T16235 28479-28492 http://purl.obolibrary.org/obo/GO_0071897 denotes DNA synthesis
T16236 28483-28492 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T16476 28999-29009 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T16477 29010-29020 http://purl.obolibrary.org/obo/GO_0008219 denotes Cell death
T16478 29004-29009 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T16479 29015-29020 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T16480 29145-29147 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T1051 1442-1448 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T1052 1512-1520 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T1053 1567-1576 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T1054 3729-3738 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T1055 1567-1576 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T1056 3729-3738 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T1057 1673-1700 http://purl.obolibrary.org/obo/GO_0038055 denotes bone morphogenetic proteins
T1058 1882-1896 http://purl.obolibrary.org/obo/GO_0001503 denotes bone formation
T1059 1887-1896 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T1060 1981-1994 http://purl.obolibrary.org/obo/GO_0009790 denotes embryogenesis

GO-MF

Id Subject Object Predicate Lexical cue
T2205 1442-1457 http://purl.obolibrary.org/obo/GO_0005160 denotes growth factor β
T2206 1646-1654 http://purl.obolibrary.org/obo/GO_0005160 denotes activins
T2207 1655-1663 http://purl.obolibrary.org/obo/GO_0005160 denotes inhibins
T6179 8690-8701 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T6180 8694-8701 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T6181 8694-8710 http://purl.obolibrary.org/obo/GO_0005515 denotes binding proteins
T6182 9027-9029 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T12251 19771-19781 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T14292 24210-24220 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T14293 24316-24322 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T14962 24663-24673 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T14963 25263-25273 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T14964 25541-25551 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T14965 24726-24728 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T14966 24901-24903 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T14967 25046-25048 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T14968 25240-25242 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T14969 25489-25491 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T14970 25707-25709 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T14971 25372-25374 http://purl.obolibrary.org/obo/GO_0004066 denotes AS
T15487 26417-26427 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T15488 26643-26653 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T15489 26501-26503 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T15490 26684-26686 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T15491 26688-26703 http://purl.obolibrary.org/obo/GO_0003824 denotes Enzyme activity
T15492 26925-26927 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T16125 27295-27297 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T16126 27642-27644 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T16600 29145-29147 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T5104 7358-7364 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T5105 7365-7372 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T5106 8425-8428 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T7018 10669-10671 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T7019 11368-11378 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T7020 11419-11429 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T12245 13836-13843 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12246 19745-19752 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12247 14396-14399 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T12248 14431-14434 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T12249 14717-14720 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T12250 15371-15373 http://purl.obolibrary.org/obo/GO_0003964 denotes RT

GO-CC

Id Subject Object Predicate Lexical cue
T743 40-45 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T744 481-486 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T745 503-508 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T746 866-871 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T747 1023-1028 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T748 1086-1091 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T749 1169-1174 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T750 1280-1285 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T751 1303-1307 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2208 2116-2121 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2209 2390-2395 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2210 2509-2514 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2211 2546-2551 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2212 2661-2666 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2213 3604-3609 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2214 3669-3674 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2215 3767-3772 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2216 3985-3990 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2217 3469-3476 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T3432 4096-4101 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3433 4162-4167 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3434 4234-4239 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3435 4442-4447 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3436 4718-4723 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3437 4882-4887 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3438 5302-5307 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3439 5354-5359 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3440 5443-5448 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3441 5706-5711 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3442 5752-5757 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3443 5041-5054 http://purl.obolibrary.org/obo/GO_0005576 denotes extracellular
T3952 5786-5790 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3953 6116-6120 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3954 6257-6261 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3955 6348-6352 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3956 6374-6379 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3957 6435-6440 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4417 6510-6515 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4418 6612-6617 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4419 6695-6700 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4420 6921-6926 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4421 6945-6950 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4422 7070-7075 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4423 7093-7098 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4424 7218-7223 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4425 7234-7239 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5107 7647-7652 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5108 8157-8162 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5109 8180-8185 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5110 8325-8330 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5111 8455-8460 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6183 8803-8808 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6184 9127-9132 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6185 10143-10148 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7021 10218-10223 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7022 10385-10390 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7023 10435-10440 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7024 10634-10639 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7025 11173-11178 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7026 11320-11325 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7027 11368-11378 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T7028 11419-11429 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T7029 11368-11378 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T12252 11620-11625 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12253 11723-11728 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12254 11870-11875 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12255 11934-11939 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12256 12306-12311 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12257 12717-12722 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12258 12975-12980 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12259 13078-13083 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12260 13138-13143 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12261 13224-13229 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12262 13344-13349 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12263 13607-13612 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12264 13695-13700 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12265 14139-14144 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12266 14259-14264 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12267 14743-14748 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12268 14930-14935 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12269 15114-15119 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12270 15460-15465 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12271 15770-15775 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12272 15989-15994 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12273 16100-16105 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12274 16368-16373 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12275 16434-16439 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12276 16490-16495 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12277 16972-16977 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12278 17212-17217 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12279 17911-17916 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12280 18607-18612 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12281 18707-18712 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12282 18823-18828 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12283 18882-18887 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12284 18952-18957 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12285 19178-19183 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12286 19411-19416 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12287 19478-19483 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12288 19831-19836 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12289 20083-20088 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12290 20168-20173 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12291 21055-21060 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12292 21148-21153 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12293 21279-21284 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12294 21342-21347 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12295 21371-21376 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12296 21615-21620 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12297 21805-21810 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12298 22150-22155 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12299 17866-17879 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T12300 19771-19781 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T12301 19771-19781 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T13637 22234-22247 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T13638 22282-22287 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13639 22403-22408 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13640 22547-22552 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13641 22563-22568 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13642 22680-22684 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T13643 22736-22740 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T14294 24210-24220 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T14295 24210-24220 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T14972 24663-24673 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T14973 25263-25273 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T14974 25541-25551 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T14975 24663-24673 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T14976 25263-25273 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T14977 25541-25551 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T14978 25561-25565 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T15493 25977-25982 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15494 26017-26021 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T15495 26417-26427 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T15496 26643-26653 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T15497 26417-26427 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T15498 26643-26653 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T16127 28376-28381 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16128 28434-28439 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7030 11419-11429 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T14109 22790-22794 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T14110 22825-22830 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T14111 23153-23158 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T14112 23335-23340 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T14113 23350-23355 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T14114 23441-23445 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T14115 23791-23795 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T14116 23515-23518 http://purl.obolibrary.org/obo/GO_1990295 denotes PAA
T15201 25718-25722 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T15202 25772-25777 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15203 25810-25815 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16460 28442-28446 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T16461 28500-28505 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16462 28517-28522 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16463 28540-28545 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16464 28555-28560 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16465 28622-28627 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16466 28747-28752 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16467 28787-28791 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T16601 28999-29003 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T16602 29010-29014 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T16603 29074-29079 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16604 29196-29201 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T1034 1414-1581 Sentence denotes Members of the transforming growth factor β (TGF-β) superfamily play central roles in controlling cellular proliferation, differentiation, migration and apoptosis [1].
T1035 1582-1759 Sentence denotes These cytokines can be divided into three subgroups: TGF-β, the activins/inhibins, and the bone morphogenetic proteins (BMPs), of which the latter constitute the largest family.
T1036 1760-1903 Sentence denotes BMPs are 30–38 kDa hetero- or homodimeric proteins originally identified by their ability to induce ectopic cartilage and bone formation [2,3].
T1037 1904-2041 Sentence denotes Several studies have demonstrated an essential role of these proteins during embryogenesis, and more recently, also in adult tissues [1].
T1038 2042-2202 Sentence denotes TGF-β has been intensively studied in normal and malignant haematopoietic cells and is one of the most potent endogenous negative regulators known to date. [4].
T1039 2203-2289 Sentence denotes In contrast, the effect of BMPs in the immune system has not been widely investigated.
T1040 2290-2435 Sentence denotes In that respect, BMP- 2, -4 and -7 have been found to control differentiation of hematopoietic stem cells [5] and early T cell development [6,7].
T1041 2436-2556 Sentence denotes BMP-6 has been reported to reduce the number of cobblestone-area-forming cells of normal human haematopoietic cells [8].
T1042 2557-2674 Sentence denotes Furthermore, BMP-2, -4, 6 and -7 had an antiproliferative and a proapoptotic effect on multiple myeloma cells [9-11].
T1043 2675-2887 Sentence denotes In addition, by gene expression profiling, BMP-6 significantly increased the predictive value for a multi-gene signature test and was associated with a poor outcome in diffuse large B cell lymphomas (DLBCL) [12].
T1044 2888-3144 Sentence denotes BMP-6, like the other BMP members, signals through ligation and heterodimerzation of BMP type I [activin-like-kinase (ALK)] and type II serine-threonine kinase receptors, which subsequently propagates the signal downstream by phosphorylating Smad proteins.
T1045 3145-3380 Sentence denotes BMP-6 can signal through the ligation of the type I receptors Act-RIA, BMP-RIA, and BMP-RIB and the type II receptors BMP-RII, Act-RIIA and Act-RIIB, which lead to the phosphorylation of the receptor Smads (Smad-1, Smad-5, and Smad-8).
T1046 3381-3517 Sentence denotes The R- Smads then form complexes with the co-Smad (Smad4) and are translocated into the nucleus where they exert gene regulation [1,13].
T1047 3518-3675 Sentence denotes Given the reported role of BMP-6 in B-cell malignancies and haematopoietic progenitor cells, we wanted to explore its potential role in normal human B cells.
T1048 3676-3773 Sentence denotes We studied the effects of BMP-6 on proliferation and apoptosis on resting and stimulated B cells.
T1049 3774-3949 Sentence denotes Furthermore, the expression of BMP receptors and BMP-6 induced activation of the Smad signalling pathway with subsequent regulation of the target genes Id1–Id4, were resolved.
T1050 3950-4028 Sentence denotes Finally, we investigated whether B cells also were capable of producing BMP-6.
T2626 4039-4101 Sentence denotes BMP-6 inhibits anti-IgM induced proliferation of human B cells
T2627 4102-4240 Sentence denotes The effects of BMP-6 on normal and neoplastic hematopoietic cells prompted us to investigate the effects of BMP-6 on normal human B cells.
T2628 4241-4392 Sentence denotes All experiments in this study were performed under serum-free conditions as FCS has been shown to interfere with BMP-signalling [14](own observations).
T2629 4393-4566 Sentence denotes To study the effect of BMP-6 on proliferation, B-cells from healthy volunteers were stimulated with anti-IgM and/or CD40L in the presence or absence of BMP-6 for three days.
T2630 4567-4681 Sentence denotes We found that BMP-6 led to a 35% mean reduction of anti-IgM- induced DNA synthesis (n = 8; p ≤ 0.0002, Figure 1A).
T2631 4682-4795 Sentence denotes Similar results were obtained for B cells treated with anti-IgM and CD40L (26% mean reduction, n = 6; p ≤ 0.023).
T2632 4796-4985 Sentence denotes The BMP-6-induced inhibition of proliferation was dose-dependent in both peripheral B cells (Figure 1B) and the Burkitt lymphoma cell line Ramos (40% reduction of DNA synthesis, Figure 1C).
T2633 4986-5084 Sentence denotes The BMP-6 effects could be reversed by addition of the extracellular inhibitor Noggin (Figure 1D).
T2634 5085-5220 Sentence denotes Similarly, a combination of the soluble BMP receptors BMP-RIB-Fc and BMP-RII-Fc also neutralized the effects of BMP-6 (data not shown).
T2635 5221-5308 Sentence denotes Next, we wanted to test whether BMP-6 had different effect on naïve and memory B cells.
T2636 5309-5525 Sentence denotes Naïve (CD19+CD27-) and memory (CD19+CD27+) B cells were isolated from peripheral blood by cell sorting of immunobead-isolated CD19+ B cells [15], and tested for their capacity to proliferate in the presence of BMP-6.
T2637 5526-5770 Sentence denotes However, BMP-6 inhibited anti-IgM induced DNA synthesis in the two subpopulations to a similar extent, with a mean reduction of DNA-synthesis of 45% (n = 5; p ≤ 0,004) for naïve B cells and 48% (n = 5; p ≤ 0,001) for memory B cells (Figure 1E).
T3578 5772-5836 Sentence denotes BMP-6 induces cell death in human memory B cells and Ramos cells
T3579 5837-5930 Sentence denotes Next, we wanted to establish whether BMP-6 also could affect the viability of normal B cells.
T3580 5931-6044 Sentence denotes Cell viability was determined by propidium iodide (PI) staining after culture with or without BMP-6 for 48 hours.
T3581 6045-6205 Sentence denotes Interestingly, BMP-6 showed a small, but reproducible mean increase of cell death from 17 to 23% (n = 5; p ≤ 0,003) in anti-IgM stimulated CD27+ memory B cells.
T3582 6206-6334 Sentence denotes Furthermore, Ramos cells showed a mean increase in cell death from 20 to 50% (n = 3, p < 0,001, figure 3) after BMP-6 treatment.
T3583 6335-6500 Sentence denotes In contrast, cell death of total CD19+ cells (n = 6; p ≤ 0,32; data not shown) or CD27-IgG- naïve B cells was not significantly affected (n = 5; p ≤ 0,65, figure 2).
T4052 6502-6539 Sentence denotes Human B cells express BMP-6 receptors
T4053 6540-6645 Sentence denotes Detailed knowledge regarding expression of different BMP receptors in B cells is currently not available.
T4054 6646-6774 Sentence denotes To further elucidate the role of BMPs in human B cells, we performed western blot analysis for type I and type II BMP receptors.
T4055 6775-6938 Sentence denotes This analysis revealed that the type I receptors Act-RIA, BMP-RIB and the type II receptors BMP-RII and Act-RIIb are expressed on resting human B-cells (Figure 4).
T4056 6939-7087 Sentence denotes Ramos cells expressed the type I receptors Act-RIA, weakly BMP-RIB and the type II receptor BMP-RII, but more weakly than normal B cells (Figure 4).
T4057 7088-7165 Sentence denotes HL60 cells were used for comparison and weakly expressed Act-RIA and BMP-RII.
T4058 7166-7308 Sentence denotes Taken together, these data show that normal human B cells and Ramos cells express a set of BMP receptors, previously shown to bind BMP-6 [16].
T4599 7310-7352 Sentence denotes BMP-6 induces phosphorylation of Smad1/5/8
T4600 7353-7449 Sentence denotes Upon ligand binding, the type II receptor transphosphorylates and activates the type I receptor.
T4601 7450-7499 Sentence denotes Type I receptors can signal via several pathways.
T4602 7500-7644 Sentence denotes We examined the effect of BMP-6 on Smad phosphorylation, as the activation of Smad is considered to be a major signalling pathway for BMPs [17].
T4603 7645-7750 Sentence denotes B cells were cultured in serum-free media over night and then treated with BMP-6 for various time points.
T4604 7751-7886 Sentence denotes Total protein lysates were prepared, and the amounts of the phosphorylated forms of Smad1/5/8 were determined by western blot analysis.
T4605 7887-8108 Sentence denotes Interestingly, treatment with 500 ng/ml BMP-6 induced phosphorylation of Smad. The BMP-6 induced phosphorylation was high at the earliest time point tested (15 minutes), and remained high for at least 48 hours (Figure 5).
T4606 8109-8197 Sentence denotes A similar phosphorylation was observed in Ramos cells, but not in HL60 cells (Figure 6).
T4607 8198-8331 Sentence denotes Furthermore, we also tested whether other known downstream signalling pathways of BMP-6 could be triggered by BMP-6 in human B cells.
T4608 8332-8478 Sentence denotes However, we did not observe any significant changes in the level of phospho-STAT3 or phospho-p38 upon BMP-6 treatment of B cells (data not shown).
T5443 8480-8513 Sentence denotes BMP-6 induces upregulation of Id1
T5444 8514-8655 Sentence denotes Next, we wanted to explore whether the BMP-6 induced phosphorylation of Smad 1/5/8 also could induce transcriptional changes of target genes.
T5445 8656-8794 Sentence denotes In this regard, the inhibitors of DNA binding proteins (Ids) are considered to be some of the major target genes for Smad-signalling [17].
T5446 8795-8971 Sentence denotes Thus, B cells were pre-incubated over night in X-VIVO 15, and then cultured in medium alone or in the presence of BMP-6 for various time points before preparation of total RNA.
T5447 8972-9034 Sentence denotes The amount of Id1–Id4 mRNA was quantified by real-time RT-PCR.
T5448 9035-9144 Sentence denotes Interestingly, we observed a specific four-fold upregulation of Id1 mRNA in BMP-6-treated B cells (Figure 7).
T5449 9145-9326 Sentence denotes The up-regulation of Id1 mRNA was characteristic of an early inducible gene, with maximal upregulation two hours after the addition of BMP-6 and returned to baseline after 24 hours.
T5450 9327-9470 Sentence denotes In contrast, no significant changes were observed for Id2 and Id3 mRNA, whereas Id4-transcripts were not detectable (Figure 7, data not shown).
T5451 9471-9611 Sentence denotes Western blot analysis revealed that the BMP-6-induced upregulation of Id1 mRNA also was correlated with upregulation of Id1 protein as well.
T5452 9612-9811 Sentence denotes The increase in Id1 protein level was detectable after one hour and increased until 24 hours after BMP-6 addition, showing a 16-fold upregulation compared with t0 (p ≤ 0.020, n = 4) (Figure 8 and 9).
T5453 9812-9934 Sentence denotes In line with the mRNA data, no consistent change in the amounts of Id2 and Id3 protein could be observed (Figure 8 and 9).
T5454 9935-10020 Sentence denotes We were able to block the Id1 specific band with a blocking peptide (data not shown).
T5455 10021-10194 Sentence denotes Taken together, these data suggest that Id1 could be a possible target gene for mediating the effects of BMP-6 in human B cells, whereas Id2 and Id3 not seem to be involved.
T6481 10196-10223 Sentence denotes BMP-6 production in B cells
T6482 10224-10428 Sentence denotes The fact that BMP-6 has been reported to act as an autocrine stimulator in chondrocytes [18] and ovarium [19], prompted us to investigate whether normal human B cells could produce BMP-6 upon stimulation.
T6483 10429-10592 Sentence denotes Ramos cells, which have been described to express BMP-6 mRNA endogenously [20], and the T cell line Jurkat, served as positive and negative controls, respectively.
T6484 10593-10734 Sentence denotes Endogenous BMP-6 mRNA levels in normal B cells were quantified by real-time RT-PCR after stimulation with anti-IgM for different time points.
T6485 10735-10912 Sentence denotes Interestingly, the up-regulation of BMP-6 mRNA was characteristic of an early-to intermediate inducible gene with maximal upregulation four hours after the addition of anti-IgM.
T6486 10913-11002 Sentence denotes The level of BMP-6 mRNA was back to baseline after 24 hours upon stimulation (Figure 10).
T6487 11003-11103 Sentence denotes Furthermore, both FCS and human AB-serum induced significant upregulation of BMP-6 mRNA (Figure 11).
T6488 11104-11267 Sentence denotes Interestingly, in a separate study we have found that normal human T cells do not express BMP-6 mRNA after activation (Sivertsen et al, manuscript in preparation).
T6489 11268-11379 Sentence denotes Next, we wanted to detect BMP-6 protein in normal B-cells and tested various commercially available antibodies.
T6490 11380-11506 Sentence denotes However, in our hands these anti-BMP-6 antibodies did only recognize the recombinant BMP-6 protein and not the native protein.
T7807 11519-11762 Sentence denotes Recent studies have demonstrated an important role for BMP superfamily members in hematopoietic stem cells, early thymocytes [6,7] and B-cell malignancies [8,11,12], but a role for BMPs in normal human B cells has previously not been reported.
T7808 11763-11876 Sentence denotes The present study demonstrated a significant antiproliferative effect of BMP-6 in peripheral blood CD19+ B cells.
T7809 11877-11991 Sentence denotes Additionally, BMP-6 induced cell death in CD27+ memory B cells as well as in a Burkitt lymphoma cell line (Ramos).
T7810 11992-12077 Sentence denotes Importantly, BMP-6 induced a rapid and marked increase in Smad-1/5/8 phosphorylation.
T7811 12078-12210 Sentence denotes Furthermore, the BMP-6 induced Smad phosphorylation was followed by a selective upregulation of Id1 mRNA and subsequent Id1 protein.
T7812 12211-12347 Sentence denotes In the present study, the demonstrated antiproliferative effect of BMP-6 in anti-IgM treated B cells was significant and dose-dependent.
T7813 12348-12567 Sentence denotes Importantly, the anti-proliferative effect of BMP-6 could be completely neutralized by the use of a natural inhibitor, Noggin. This is in line with others, showing that Noggin can function as a BMP-6 antagonist [21,22].
T7814 12568-12723 Sentence denotes In addition, the combination of soluble BMP-RIB-Fc and BMP-RII-Fc fusion proteins also neutralized the anti-proliferative effect of BMP-6 in human B cells.
T7815 12724-12830 Sentence denotes Interestingly, as for other TGF family members, bifunctional effects have also been demonstrated for BMPs.
T7816 12831-13084 Sentence denotes Whereas several of the BMPs have been shown to promote proliferation in various cell types including condrocytes [23], liver [24] and granulosa cells [25], antiproliferative effects and induction of apoptosis has been reported for B and T lineage cells.
T7817 13085-13237 Sentence denotes Similar effects as demonstrated for BMP-6 on human B cells in the present study, were demonstrated for BMP-2, 4, 6 and -7 in human myeloma cells [9-11].
T7818 13238-13355 Sentence denotes Other members of the BMP-family have also been reported to induce apoptosis, including in mouse B lineage cells [26].
T7819 13356-13413 Sentence denotes Additionally, BMP-4 inhibits thymocyte proliferation [6].
T7820 13414-13550 Sentence denotes Taken together, these data suggest that the role of BMPs in the regulation of proliferation and apoptosis is highly cell type dependent.
T7821 13551-13675 Sentence denotes To examine how BMP-6 exerts its functional effects in B cells, we analysed BMP receptor expression by western blot analysis.
T7822 13676-13885 Sentence denotes Human peripheral B cells were found to express the BMP type I receptors Act-RIA and BMP-RIB, and the type II-receptors BMP-RII and Act-RIIb, which signal after binding of several BMPs, including BMP-6 [16,13].
T7823 13886-13974 Sentence denotes To further explore BMP-6 induced signalling, activation of several pathways is possible.
T7824 13975-14052 Sentence denotes The major signalling pathway known to date, is activation of R-Smads [13,27].
T7825 14053-14183 Sentence denotes In that respect, BMPs have been shown to exert antiproliferative effects in B lineage cells via phosphorylation of R-Smad [11,28].
T7826 14184-14269 Sentence denotes Furthermore, BMP-2 has been shown to induce activation of STAT3 in myeloma cells [9].
T7827 14270-14340 Sentence denotes However, phosphorylation of R-Smad was not investigated in that study.
T7828 14341-14405 Sentence denotes BMP-2 has also been shown to induce phosphorylation of p38 [29].
T7829 14406-14603 Sentence denotes Thus, phosphorylation of p38, STAT3 and Smad1/5/8 represent important BMP-signalling pathways that mediated the effects of BMPs and even cross-talk between these pathways has been reported [29,30].
T7830 14604-14749 Sentence denotes In the present study, we were not able to detect BMP-6-induced changes in the phosphorylation status of STAT3 or p38 in human peripheral B cells.
T7831 14750-14820 Sentence denotes Instead, a rapid and marked phosphorylation of Smad1/5/8 was revealed.
T7832 14821-14953 Sentence denotes In a parallel study, we have found that other BMPs also induced phosphorylation of Smad1/5/8 in peripheral B cells (data not shown).
T7833 14954-15120 Sentence denotes We are currently pursuing microarray studies to identify the signalling pathways and target genes that are differently regulated by the various BMPs in human B cells.
T7834 15121-15338 Sentence denotes Upregulation of Id1 via Smad1/5/8 phosphorylation is a known mechanism for BMP-6 signalling in other cell systems [31,32] and regulation of Id-proteins is thought to be an important mechanism for Smad-signalling [17].
T7835 15339-15514 Sentence denotes In the present study, real-time RT-PCR experiments revealed a specific four-fold upregulation for Id1 in BMP-6-treated B cells, while the amount of Id2–Id4 remained unchanged.
T7836 15515-15672 Sentence denotes In agreement with this, western blot analysis demonstrated an upregulation of Id1 protein, while the amount of Id2 and Id3 protein levels remained unchanged.
T7837 15673-15875 Sentence denotes Previously, Id1 has been considered not to be expressed in later developmental stages than pro-B cells [33,34], and its constitutive expression has been reported to impair mouse B cell development [35].
T7838 15876-16021 Sentence denotes Therefore, our demonstration of the time-dependent upregulation of Id1 mRNA and protein in mature normal human B cells is of particular interest.
T7839 16022-16180 Sentence denotes In that respect, it is noteworthy that TGF-β signalling in early and mature B cells induces both Id2 and Id3 expression [36,37], but not Id1 (data not shown).
T7840 16181-16289 Sentence denotes Interestingly, these results show that various members of the TGF-β family regulate Id proteins differently.
T7841 16290-16379 Sentence denotes Id2 and Id3 are considered to be the Id proteins mainly expressed in mature B cells [38].
T7842 16380-16496 Sentence denotes The present study also found Id2 and Id3 protein in B cells to be more highly expressed than Id1 in resting B cells.
T7843 16497-16588 Sentence denotes However, BMP-6 did not induce significant changes in the protein expression of Id2 and Id3.
T7844 16589-16699 Sentence denotes It is believed that Id proteins block differentiation and promote proliferation in various cell types [39,33].
T7845 16700-16850 Sentence denotes Id proteins act as dominant-negative inhibitors of E-proteins and Pax5 function by forming dimers with these proteins, making them unable to bind DNA.
T7846 16851-16983 Sentence denotes It has been proposed that the balance among E-proteins, Pax5 and Id proteins might have an important role in activated B cells [38].
T7847 16984-17149 Sentence denotes In that respect, E-proteins have been implicated in both the promotion and inhibition of cell survival and growth at different points in lymphocyte development [40].
T7848 17150-17419 Sentence denotes The antiproliferative and death inducing effect of BMP-6 in B cells with concomitant upregulation of Id1 protein is therefore in line with the view that Id proteins are required for the induction of growth arrest and apoptosis in B-lymphocyte progenitors by TGF-β [40].
T7849 17420-17556 Sentence denotes Furthermore, Id proteins are known as important parts of signalling pathways involved in development, cell cycle and tumorigenesis [32].
T7850 17557-17817 Sentence denotes It is well established that various members of the Id family are overexpressed in a range of human tumours and generally, Id1 appears to be the family member most widely overexpressed in a variety of human malignancies [41], including multiple myeloma [42,32].
T7851 17818-18000 Sentence denotes Additionally, our findings that BMP-6 activates intracellular signalling pathways in human B cells might be of potential pathophysiological significance in lymphoma and inflammation.
T7852 18001-18094 Sentence denotes High BMP-6 mRNA expression in DLBCL has been shown to correlate to unfavourable outcome [12].
T7853 18095-18291 Sentence denotes In this respect, it is of interest that targeted expression of Id1 to B-lymphocytes resulted in aberrant B cell development, massive apoptosis, and subsequent development of B cell lymphomas [35].
T7854 18292-18465 Sentence denotes Moreover, BMP-6 has been suggested to play a role in rheumatoid arthritis (RA) [43,44] and elevated levels of Id1 and Id3 have been found in the synovia of RA-patients [45].
T7855 18466-18626 Sentence denotes Altogether, these results point to an important role for Id proteins in the regulation of normal B cell homeostasis and in diseases, where B cells are involved.
T7856 18627-18780 Sentence denotes It will therefore be important to further elucidate the role of Id-1 in human B cells by selective over expression or inhibition of Id-1 gene expression.
T7857 18781-19021 Sentence denotes Given the role of BMP-6 in mature human B cells demonstrated here, identification of BMP-6 producing cells in vivo with possibility of interaction with naïve and memory B cells might contribute to the understanding of mature B cell biology.
T7858 19022-19110 Sentence denotes High BMP-6 mRNA expression in DLBCL has been detected by gene expression profiling [12].
T7859 19111-19215 Sentence denotes Furthermore, production of BMP-6 transcripts in normal activated B cells was detected in the same study.
T7860 19216-19323 Sentence denotes Of note, an autocrine BMP-6 loop has been reported by others in chondrocytes and in the ovarium [46,19,18].
T7861 19324-19417 Sentence denotes Therefore, we wanted to explore the possibility for an autocrine BMP-6 loop in human B cells.
T7862 19418-19642 Sentence denotes We analysed the expression BMP-6 mRNA in peripheral blood B cells by real-time PCR, and report here the upregulation of endogenous BMP-6 transcripts after stimulation with FCS, human AB-serum and, most importantly, anti-IgM.
T7863 19643-19865 Sentence denotes However, our attempts to study BMP-6 protein levels were unsuccessful due to problems with unspecific binding of the anti-BMP-6 antibodies tested, and lack of specific staining in control cells known to express BMP-6 mRNA.
T7864 19866-19924 Sentence denotes In contrast, the recombinant protein was readily detected.
T7865 19925-20035 Sentence denotes In that respect, few investigators have detected BMP-6 protein in humans, especially in non-pathogenic tissue.
T7866 20036-20245 Sentence denotes The possibility of BMP-6 production in human B-cells is in line with a recent work that reported the production of BMP-6 in mouse B cells, infiltrating the bone marrow of mice with inflammatory arthritis [43].
T7867 20246-20333 Sentence denotes In this study, a role for BMPs in the inflammatoric process of arthritis was suggested.
T7868 20334-20436 Sentence denotes The upregulation of the BMP-6-transcripts after IgM-crosslinking is of pathophysiologic interest [12].
T7869 20437-20616 Sentence denotes A loss of TGF-β-responsiveness has been suggested to be a critical contribution to malignant transformation [47,48] and similar oncogenic mechanisms have been postulated for BMPs.
T7870 20617-20773 Sentence denotes Lines of evidence suggest [49] that at early stages of carcinogenesis, BMP-6 is not a tumour promoter, but suppresses benign and malignant tumour outgrowth.
T7871 20774-20997 Sentence denotes These findings are in good agreement with previous findings for other TGF-β family members, including TGF-β1 and BMP-4 [50], indicating that cellular context of the BMP target cell might define the various observed effects.
T7872 20998-21298 Sentence denotes In contrast to the upregulation of BMP-6 transcript in B cells, we were not able to detect BMP-6 transcripts in human peripheral blood CD4+ or CD8+ T cells (resting or stimulated with anti-CD3 and anti-CD28; data not shown), consistent with the findings in T cell lines [20] and T cells in mice [43].
T7873 21299-21449 Sentence denotes Other potential BMP-6 sources for mature B cells in vivo might be other cells of the immune system or tissue with contact to the hematopoietic system.
T7874 21450-21546 Sentence denotes One well recognized source for BMP-6 production is the human bone and bone marrow stroma [51,8].
T7875 21547-21726 Sentence denotes Furthermore, it is noteworthy that human umbilical vein endothelial cells (HUVEC) highly express BMP-6 mRNA [52], and vascular endothelium has been reported to produce BMP-6 [53].
T7876 21727-21811 Sentence denotes These studies might imply a role for BMP-6 in transendothelial migration of B cells.
T7877 21812-21901 Sentence denotes BMP-6 mRNA has been demonstrated in murine macrophage cell lines, but not in humans [54].
T13400 22169-22331 Sentence denotes In conclusion, our results show that BMP-6 induces activation of intracellular Smad signalling in mature human B-cells with consecutive production of Id1 protein.
T13401 22332-22485 Sentence denotes Furthermore, we report that BMP-6 has an antiproliferative effect in B cells stimulated with anti-IgM alone or the combined action of anti-IgM and CD40L.
T13402 22486-22569 Sentence denotes Additionally, BMP-6 induces cell death in activated memory B cells and Ramos cells.
T13403 22570-22779 Sentence denotes Taken together, these results provide a rationale to further examine the role of BMP-6 signalling in normal B cell biology as well as in pathologic conditions like B cell malignancies and autoimmune disorders.
T13700 22790-22802 Sentence denotes Cell culture
T13701 22803-22937 Sentence denotes If not specified, all cells were cultured in X-VIVO 15™ (BioWhittaker, Verviers, Belgium) serum-free medium at 37°C and 5% CO2 in air.
T13702 22938-23101 Sentence denotes Peripheral blood was provided by the Blood Bank at Buskerud Regional Hospital with formal agreement by the patients, and approval by the regional ethics committee.
T13703 23102-23295 Sentence denotes Highly purified resting human B-lymphocytes (CD19+ cells) were isolated from the peripheral blood by rosetting with immunomagnetic beads (Dynabeads M450; Dynal, Oslo, Norway) as described [55].
T13704 23296-23426 Sentence denotes This procedure yields less than 0.5% T cells, 0.1% NK cells, and 0.5% monocytes as judged by indirect immunofluorescence staining.
T13705 23427-23842 Sentence denotes The following cell lines from human lymphoid malignancies were maintained in RPMI 1640 (PAA Laboratories GmbH, Pasching, Austria) supplemented with 10% foetal bovine serum (FCS), 100 units/ml penicillin G, and 100 units/ml of streptomycin sulphate, but serum-starved for at least four hours and cultured in X-VIVO 15™ when included in experiments: EBV-negative BL cell lines Ramos (ECACC 85030802), HL60 (JCRB0085).
T14146 23844-23870 Sentence denotes Growth factors/supplements
T14147 23871-24385 Sentence denotes The following reagents were used at indicated concentrations: recombinant human (rhu) BMP-6 (1 μg/ml, if not specified otherwise), rhu BMP-RIB/ALK-6/Fc Chimera (5 μg/ml), rhu BMPR-II/Fc Chimera (5 μg/ml), and recombinant mouse Noggin (5 μg/ml) were purchased from R&D Systems (Abingdon, UK); Anti-IgM F(ab)2 fragments of rabbit polyclonal antibodies to human IgM heavy chain (37.5 μg/ml) was obtained from Dako, Copenhagen, Denmark and rhu CD40 ligand (CD40L, 10 ng/ml) was a gift from Immunex Corp. (Seattle, WA).
T14407 24387-24455 Sentence denotes Antibodies used for flow cytometric analysis and immunoblot analysis
T14408 24456-24597 Sentence denotes Antibodies against the human BMP-receptors Act-RIA, BMP-RIB, BMPR-II, Act-RIIA and Act-RIIb were purchased from R & D Systems (Abingdon, UK).
T14409 24598-24910 Sentence denotes Detection of the BMP-6-protein has been tried with the following antibodies: goat polyclonal anti-BMP-6 (Santa Cruz, San Diego, CA, USA), monoclonal mouse anti-BMP-6 and polyclonal goat anti-BMP-6 from R & D Systems (Abingdon, UK), and mouse monoclonal anti-BMP-6 (Chemicon International Inc, Temecula, CA, USA).
T14410 24911-25055 Sentence denotes Characterisation of BMP-signalling pathways was done by use of anti-phospho-Smad1, -5, -and 8 polyclonal antibody (Chemicon, Temecula, CA, USA).
T14411 25056-25249 Sentence denotes Expression levels of Id1–3 proteins were detected with polyclonal rabbit antibody and detection was blocked with blocking peptide from Santa Cruz Biotechnology (Santa Cruz, San Diego, CA, USA).
T14412 25250-25421 Sentence denotes As secondary antibodies served anti-mouse, anti-goat or anti-rabbit IgG- horseradish peroxidase (HRP) from Dakocytomation AS (Copenhagen, Denmark) for immunoblot analysis.
T14413 25422-25536 Sentence denotes Anti-β-actin was from Santa-Cruz. From Becton Dickinson (San Jose, CA), we purchased anti-CD19-PE, anti-CD19-FITC.
T14414 25537-25716 Sentence denotes The antibodies used for cell sorting were anti-CD19 PC5 from Immunotech SA (Marseille, France) and anti-CD27 PE from Becton Dickinson, Biosciences Pharmingen (San Diego, CA, USA).
T15100 25718-25730 Sentence denotes Cell sorting
T15101 25731-25951 Sentence denotes Highly purified CD19+CD27- or CD19+CD27+ cells were obtained by staining CD19+ cells with anti-CD27 PE and CD19 PC5 mAbs for 30 minutes at 4°C, followed by washing with PBS and sorting on FACS DiVa from Becton Dickinson.
T15255 25953-25974 Sentence denotes Western-blot analysis
T15256 25975-26161 Sentence denotes B cells from peripheral blood or cultured cell-lines were lysed in lysis buffer (glycerol 10%, β-mercaptoethanol 5%, 0.0625 M Tris-HCL [pH 6.8], sodium dodecyl sulphate [SDS] 2.5%w/vol).
T15257 26162-26355 Sentence denotes Total protein (30–100 μg) from each sample was run on 10% or 12% SDS/polyacrylamide (SDS/PAGE) gels and blotted onto nitrocellulose filters (Protran; Schleicher &Schuell GmbH, Dassel, Germany).
T15258 26356-26505 Sentence denotes Blocking, washing and incubation of the filters with primary antibodies were done according to the manufacturer's protocols at room temperature (RT).
T15259 26506-26687 Sentence denotes After washing with TBS/0.1% Tween-20 (TBS-T), the filters were incubated with horseradish peroxidase (HRP) coupled to relevant secondary antibodies (see above) for 60 minutes at RT.
T15260 26688-26802 Sentence denotes Enzyme activity was visualised by the enhanced chemiluminescence system, ECL+PLUS (Amersham, Buckinghamshire, UK).
T15261 26803-26929 Sentence denotes Densitometric analysis was performed by scanning hyperfilms on a Personal Densitometer SI (Molecular Dynamics, Sunnyvale, CA).
T15262 26930-27093 Sentence denotes Quantification of Id1, Id2 and Id3 protein was calculated by normalizing the specific protein bands to β-actin using Image Quant 5.5 software (Molecular Dynamics).
T15588 27095-27144 Sentence denotes Analysis of BMP-6 messenger RNA (mRNA) expression
T15589 27145-27249 Sentence denotes Endogenous expression of the BMP-6 gene was examined by reverse transcription-polymerase chain reaction.
T15590 27250-27402 Sentence denotes Total RNA was isolated using Absolutely RNA™ RT-PCR Miniprep Kit (Stratagene Europe, Amsterdam, Netherland) according to the manufacturers instructions.
T15591 27403-27504 Sentence denotes Quantification of the isolated total RNA was achieved by using spectrophotometric OD260 measurements.
T15592 27505-27653 Sentence denotes Equal amounts of RNA were then reverse transcribed to cDNA with TaqMan® Reverse Transcription Reagents (Applied Biosystems, Foster City, CA, U.S.A).
T15593 27654-27762 Sentence denotes To measure mRNA expression of BMP6, Id1–Id4 and PGK1 PCR were carried out with TaqMan® universal master mix.
T15594 27763-27836 Sentence denotes Primers and probes were provided by Assay-on-Demand (Applied Biosystems).
T15595 27837-27918 Sentence denotes PCR reactions were carried out in a final volume of 25 μl (BMP-6) or 20 μl (ID1).
T15596 27919-28001 Sentence denotes The cDNA added to each reaction was equivalent to the input of 20 ng of total RNA.
T15597 28002-28173 Sentence denotes The gene expression was quantified using the standard curve method (BMP6), or the comparative CT method (Id1) as described in ABI7700 User Bulletin 2 (Applied Biosystems).
T15598 28174-28241 Sentence denotes The expression was then normalized to the expression level of PGK1.
T15599 28242-28352 Sentence denotes PGK1 was chosen, because it has been shown to have low expression variability among lymphocyte specimens [56].
T15600 28353-28440 Sentence denotes Expression levels in B cells were then related to the expression levels in Ramos cells.
T16230 28442-28460 Sentence denotes Cell proliferation
T16231 28461-28617 Sentence denotes For estimation of DNA synthesis, CD19+ cells (7.5 × 104 cells/0.2 ml) or Ramos cells (1 × 104 cells/0.2 ml) were cultured in triplicate in microtiter wells.
T16232 28618-28742 Sentence denotes The cells were pulsed with 3.7 × 104Bq [3H]thymidine (Amersham, Buckinghamshire, UK) for the last 16 h of a 72-h incubation.
T16233 28743-28980 Sentence denotes The cells were harvested using an automated cell harvester (Packard Instrument Company, Meriden, CT, USA) and [3H]thymidine incorporation was determined in a scintillation counter (TopCount, Packard Instrument Company Inc., Meriden, CT).
T16473 28982-29009 Sentence denotes Determination of cell death
T16474 29010-29180 Sentence denotes Cell death was measured by vital dye exclusion test by staining cells with 5 μg/ml propidium iodide ([PI]; Calbiochem Corp.; La Jolla, CA; 5 mg/ml) for one minute on ice.
T16475 29181-29257 Sentence denotes At least 1,000 cells per sample were run on a BD FACSCalibur flow cytometer.
T16606 29259-29279 Sentence denotes Statistical analysis
T16607 29280-29471 Sentence denotes The statistical significance of differences between groups was determined using the paired two-tailed Wilcoxon nonparametric test, by applying SPSS10.1 software (SPSS Inc., Chicago, IL, USA).
T16608 29472-29524 Sentence denotes P values less than 0.05 were considered significant.
T160 0-104 Sentence denotes BMP-6 inhibits growth of mature human B cells; induction of Smad phosphorylation and upregulation of Id1
T161 116-126 Sentence denotes Background
T162 127-272 Sentence denotes Bone morphogenetic proteins (BMPs) belong to the TGF-β superfamily and are secreted proteins with pleiotropic roles in many different cell types.
T163 273-393 Sentence denotes A potential role of BMP-6 in the immune system has been implied by various studies of malignant and rheumatoid diseases.
T164 394-487 Sentence denotes In the present study, we explored the role of BMP-6 in normal human peripheral blood B cells.
T165 489-496 Sentence denotes Results
T166 497-619 Sentence denotes The B cells were found to express BMP type I and type II receptors and BMP-6 rapidly induced phosphorylation of Smad1/5/8.
T167 620-760 Sentence denotes Furthermore, Smad-phosphorylation was followed by upregulation of Id1 mRNA and Id1 protein, whereas Id2 and Id3 expression was not affected.
T168 761-961 Sentence denotes Furthermore, we found that BMP-6 had an antiproliferative effect both in naïve (CD19+CD27-) and memory B cells (CD19+CD27+) stimulated with anti-IgM alone or the combined action of anti-IgM and CD40L.
T169 962-1029 Sentence denotes Additionally, BMP-6 induced cell death in activated memory B cells.
T170 1030-1153 Sentence denotes Importantly, the antiproliferative effect of BMP-6 in B-cells was completely neutralized by the natural antagonist, noggin.
T171 1154-1249 Sentence denotes Furthermore, B cells were demonstrated to upregulate BMP-6 mRNA upon stimulation with anti-IgM.
T172 1251-1261 Sentence denotes Conclusion
T173 1262-1400 Sentence denotes In mature human B cells, BMP-6 inhibited cell growth, and rapidly induced phosphorylation of Smad1/5/8 followed by an upregulation of Id1.
T7878 21902-22060 Sentence denotes In accordance with these findings, other human cell lines of neutrophil and monocytic origin have been described to be negative for the BMP-6 transcript [20].
T7879 22061-22156 Sentence denotes To our knowledge, there is currently no report about BMP-6 production of human dendritic cells.
T1 0-104 Sentence denotes BMP-6 inhibits growth of mature human B cells; induction of Smad phosphorylation and upregulation of Id1
T2 107-115 Sentence denotes Abstract
T3 116-126 Sentence denotes Background
T4 127-272 Sentence denotes Bone morphogenetic proteins (BMPs) belong to the TGF-β superfamily and are secreted proteins with pleiotropic roles in many different cell types.
T5 273-393 Sentence denotes A potential role of BMP-6 in the immune system has been implied by various studies of malignant and rheumatoid diseases.
T6 394-487 Sentence denotes In the present study, we explored the role of BMP-6 in normal human peripheral blood B cells.
T7 489-496 Sentence denotes Results
T8 497-619 Sentence denotes The B cells were found to express BMP type I and type II receptors and BMP-6 rapidly induced phosphorylation of Smad1/5/8.
T9 620-760 Sentence denotes Furthermore, Smad-phosphorylation was followed by upregulation of Id1 mRNA and Id1 protein, whereas Id2 and Id3 expression was not affected.
T10 761-961 Sentence denotes Furthermore, we found that BMP-6 had an antiproliferative effect both in naïve (CD19+CD27-) and memory B cells (CD19+CD27+) stimulated with anti-IgM alone or the combined action of anti-IgM and CD40L.
T11 962-1029 Sentence denotes Additionally, BMP-6 induced cell death in activated memory B cells.
T12 1030-1153 Sentence denotes Importantly, the antiproliferative effect of BMP-6 in B-cells was completely neutralized by the natural antagonist, noggin.
T13 1154-1249 Sentence denotes Furthermore, B cells were demonstrated to upregulate BMP-6 mRNA upon stimulation with anti-IgM.
T14 1251-1261 Sentence denotes Conclusion
T15 1262-1400 Sentence denotes In mature human B cells, BMP-6 inhibited cell growth, and rapidly induced phosphorylation of Smad1/5/8 followed by an upregulation of Id1.
T16 1403-1413 Sentence denotes Background
T17 1414-1581 Sentence denotes Members of the transforming growth factor β (TGF-β) superfamily play central roles in controlling cellular proliferation, differentiation, migration and apoptosis [1].
T18 1582-1759 Sentence denotes These cytokines can be divided into three subgroups: TGF-β, the activins/inhibins, and the bone morphogenetic proteins (BMPs), of which the latter constitute the largest family.
T19 1760-1903 Sentence denotes BMPs are 30–38 kDa hetero- or homodimeric proteins originally identified by their ability to induce ectopic cartilage and bone formation [2,3].
T20 1904-2041 Sentence denotes Several studies have demonstrated an essential role of these proteins during embryogenesis, and more recently, also in adult tissues [1].
T21 2042-2202 Sentence denotes TGF-β has been intensively studied in normal and malignant haematopoietic cells and is one of the most potent endogenous negative regulators known to date. [4].
T22 2203-2289 Sentence denotes In contrast, the effect of BMPs in the immune system has not been widely investigated.
T23 2290-2435 Sentence denotes In that respect, BMP- 2, -4 and -7 have been found to control differentiation of hematopoietic stem cells [5] and early T cell development [6,7].
T24 2436-2556 Sentence denotes BMP-6 has been reported to reduce the number of cobblestone-area-forming cells of normal human haematopoietic cells [8].
T25 2557-2674 Sentence denotes Furthermore, BMP-2, -4, 6 and -7 had an antiproliferative and a proapoptotic effect on multiple myeloma cells [9-11].
T26 2675-2887 Sentence denotes In addition, by gene expression profiling, BMP-6 significantly increased the predictive value for a multi-gene signature test and was associated with a poor outcome in diffuse large B cell lymphomas (DLBCL) [12].
T27 2888-3144 Sentence denotes BMP-6, like the other BMP members, signals through ligation and heterodimerzation of BMP type I [activin-like-kinase (ALK)] and type II serine-threonine kinase receptors, which subsequently propagates the signal downstream by phosphorylating Smad proteins.
T28 3145-3380 Sentence denotes BMP-6 can signal through the ligation of the type I receptors Act-RIA, BMP-RIA, and BMP-RIB and the type II receptors BMP-RII, Act-RIIA and Act-RIIB, which lead to the phosphorylation of the receptor Smads (Smad-1, Smad-5, and Smad-8).
T29 3381-3517 Sentence denotes The R- Smads then form complexes with the co-Smad (Smad4) and are translocated into the nucleus where they exert gene regulation [1,13].
T30 3518-3675 Sentence denotes Given the reported role of BMP-6 in B-cell malignancies and haematopoietic progenitor cells, we wanted to explore its potential role in normal human B cells.
T31 3676-3773 Sentence denotes We studied the effects of BMP-6 on proliferation and apoptosis on resting and stimulated B cells.
T32 3774-3949 Sentence denotes Furthermore, the expression of BMP receptors and BMP-6 induced activation of the Smad signalling pathway with subsequent regulation of the target genes Id1–Id4, were resolved.
T33 3950-4028 Sentence denotes Finally, we investigated whether B cells also were capable of producing BMP-6.
T34 4030-4037 Sentence denotes Results
T35 4039-4101 Sentence denotes BMP-6 inhibits anti-IgM induced proliferation of human B cells
T36 4102-4240 Sentence denotes The effects of BMP-6 on normal and neoplastic hematopoietic cells prompted us to investigate the effects of BMP-6 on normal human B cells.
T37 4241-4392 Sentence denotes All experiments in this study were performed under serum-free conditions as FCS has been shown to interfere with BMP-signalling [14](own observations).
T38 4393-4566 Sentence denotes To study the effect of BMP-6 on proliferation, B-cells from healthy volunteers were stimulated with anti-IgM and/or CD40L in the presence or absence of BMP-6 for three days.
T39 4567-4681 Sentence denotes We found that BMP-6 led to a 35% mean reduction of anti-IgM- induced DNA synthesis (n = 8; p ≤ 0.0002, Figure 1A).
T40 4682-4795 Sentence denotes Similar results were obtained for B cells treated with anti-IgM and CD40L (26% mean reduction, n = 6; p ≤ 0.023).
T41 4796-4985 Sentence denotes The BMP-6-induced inhibition of proliferation was dose-dependent in both peripheral B cells (Figure 1B) and the Burkitt lymphoma cell line Ramos (40% reduction of DNA synthesis, Figure 1C).
T42 4986-5084 Sentence denotes The BMP-6 effects could be reversed by addition of the extracellular inhibitor Noggin (Figure 1D).
T43 5085-5220 Sentence denotes Similarly, a combination of the soluble BMP receptors BMP-RIB-Fc and BMP-RII-Fc also neutralized the effects of BMP-6 (data not shown).
T44 5221-5308 Sentence denotes Next, we wanted to test whether BMP-6 had different effect on naïve and memory B cells.
T45 5309-5525 Sentence denotes Naïve (CD19+CD27-) and memory (CD19+CD27+) B cells were isolated from peripheral blood by cell sorting of immunobead-isolated CD19+ B cells [15], and tested for their capacity to proliferate in the presence of BMP-6.
T46 5526-5770 Sentence denotes However, BMP-6 inhibited anti-IgM induced DNA synthesis in the two subpopulations to a similar extent, with a mean reduction of DNA-synthesis of 45% (n = 5; p ≤ 0,004) for naïve B cells and 48% (n = 5; p ≤ 0,001) for memory B cells (Figure 1E).
T47 5772-5836 Sentence denotes BMP-6 induces cell death in human memory B cells and Ramos cells
T48 5837-5930 Sentence denotes Next, we wanted to establish whether BMP-6 also could affect the viability of normal B cells.
T49 5931-6044 Sentence denotes Cell viability was determined by propidium iodide (PI) staining after culture with or without BMP-6 for 48 hours.
T50 6045-6205 Sentence denotes Interestingly, BMP-6 showed a small, but reproducible mean increase of cell death from 17 to 23% (n = 5; p ≤ 0,003) in anti-IgM stimulated CD27+ memory B cells.
T51 6206-6334 Sentence denotes Furthermore, Ramos cells showed a mean increase in cell death from 20 to 50% (n = 3, p < 0,001, figure 3) after BMP-6 treatment.
T52 6335-6500 Sentence denotes In contrast, cell death of total CD19+ cells (n = 6; p ≤ 0,32; data not shown) or CD27-IgG- naïve B cells was not significantly affected (n = 5; p ≤ 0,65, figure 2).
T53 6502-6539 Sentence denotes Human B cells express BMP-6 receptors
T54 6540-6645 Sentence denotes Detailed knowledge regarding expression of different BMP receptors in B cells is currently not available.
T55 6646-6774 Sentence denotes To further elucidate the role of BMPs in human B cells, we performed western blot analysis for type I and type II BMP receptors.
T56 6775-6938 Sentence denotes This analysis revealed that the type I receptors Act-RIA, BMP-RIB and the type II receptors BMP-RII and Act-RIIb are expressed on resting human B-cells (Figure 4).
T57 6939-7087 Sentence denotes Ramos cells expressed the type I receptors Act-RIA, weakly BMP-RIB and the type II receptor BMP-RII, but more weakly than normal B cells (Figure 4).
T58 7088-7165 Sentence denotes HL60 cells were used for comparison and weakly expressed Act-RIA and BMP-RII.
T59 7166-7308 Sentence denotes Taken together, these data show that normal human B cells and Ramos cells express a set of BMP receptors, previously shown to bind BMP-6 [16].
T60 7310-7352 Sentence denotes BMP-6 induces phosphorylation of Smad1/5/8
T61 7353-7449 Sentence denotes Upon ligand binding, the type II receptor transphosphorylates and activates the type I receptor.
T62 7450-7499 Sentence denotes Type I receptors can signal via several pathways.
T63 7500-7644 Sentence denotes We examined the effect of BMP-6 on Smad phosphorylation, as the activation of Smad is considered to be a major signalling pathway for BMPs [17].
T64 7645-7750 Sentence denotes B cells were cultured in serum-free media over night and then treated with BMP-6 for various time points.
T65 7751-7886 Sentence denotes Total protein lysates were prepared, and the amounts of the phosphorylated forms of Smad1/5/8 were determined by western blot analysis.
T66 7887-7965 Sentence denotes Interestingly, treatment with 500 ng/ml BMP-6 induced phosphorylation of Smad.
T67 7966-8108 Sentence denotes The BMP-6 induced phosphorylation was high at the earliest time point tested (15 minutes), and remained high for at least 48 hours (Figure 5).
T68 8109-8197 Sentence denotes A similar phosphorylation was observed in Ramos cells, but not in HL60 cells (Figure 6).
T69 8198-8331 Sentence denotes Furthermore, we also tested whether other known downstream signalling pathways of BMP-6 could be triggered by BMP-6 in human B cells.
T70 8332-8478 Sentence denotes However, we did not observe any significant changes in the level of phospho-STAT3 or phospho-p38 upon BMP-6 treatment of B cells (data not shown).
T71 8480-8513 Sentence denotes BMP-6 induces upregulation of Id1
T72 8514-8655 Sentence denotes Next, we wanted to explore whether the BMP-6 induced phosphorylation of Smad 1/5/8 also could induce transcriptional changes of target genes.
T73 8656-8794 Sentence denotes In this regard, the inhibitors of DNA binding proteins (Ids) are considered to be some of the major target genes for Smad-signalling [17].
T74 8795-8971 Sentence denotes Thus, B cells were pre-incubated over night in X-VIVO 15, and then cultured in medium alone or in the presence of BMP-6 for various time points before preparation of total RNA.
T75 8972-9034 Sentence denotes The amount of Id1–Id4 mRNA was quantified by real-time RT-PCR.
T76 9035-9144 Sentence denotes Interestingly, we observed a specific four-fold upregulation of Id1 mRNA in BMP-6-treated B cells (Figure 7).
T77 9145-9326 Sentence denotes The up-regulation of Id1 mRNA was characteristic of an early inducible gene, with maximal upregulation two hours after the addition of BMP-6 and returned to baseline after 24 hours.
T78 9327-9470 Sentence denotes In contrast, no significant changes were observed for Id2 and Id3 mRNA, whereas Id4-transcripts were not detectable (Figure 7, data not shown).
T79 9471-9611 Sentence denotes Western blot analysis revealed that the BMP-6-induced upregulation of Id1 mRNA also was correlated with upregulation of Id1 protein as well.
T80 9612-9811 Sentence denotes The increase in Id1 protein level was detectable after one hour and increased until 24 hours after BMP-6 addition, showing a 16-fold upregulation compared with t0 (p ≤ 0.020, n = 4) (Figure 8 and 9).
T81 9812-9934 Sentence denotes In line with the mRNA data, no consistent change in the amounts of Id2 and Id3 protein could be observed (Figure 8 and 9).
T82 9935-10020 Sentence denotes We were able to block the Id1 specific band with a blocking peptide (data not shown).
T83 10021-10194 Sentence denotes Taken together, these data suggest that Id1 could be a possible target gene for mediating the effects of BMP-6 in human B cells, whereas Id2 and Id3 not seem to be involved.
T84 10196-10223 Sentence denotes BMP-6 production in B cells
T85 10224-10428 Sentence denotes The fact that BMP-6 has been reported to act as an autocrine stimulator in chondrocytes [18] and ovarium [19], prompted us to investigate whether normal human B cells could produce BMP-6 upon stimulation.
T86 10429-10592 Sentence denotes Ramos cells, which have been described to express BMP-6 mRNA endogenously [20], and the T cell line Jurkat, served as positive and negative controls, respectively.
T87 10593-10734 Sentence denotes Endogenous BMP-6 mRNA levels in normal B cells were quantified by real-time RT-PCR after stimulation with anti-IgM for different time points.
T88 10735-10912 Sentence denotes Interestingly, the up-regulation of BMP-6 mRNA was characteristic of an early-to intermediate inducible gene with maximal upregulation four hours after the addition of anti-IgM.
T89 10913-11002 Sentence denotes The level of BMP-6 mRNA was back to baseline after 24 hours upon stimulation (Figure 10).
T90 11003-11103 Sentence denotes Furthermore, both FCS and human AB-serum induced significant upregulation of BMP-6 mRNA (Figure 11).
T91 11104-11267 Sentence denotes Interestingly, in a separate study we have found that normal human T cells do not express BMP-6 mRNA after activation (Sivertsen et al, manuscript in preparation).
T92 11268-11379 Sentence denotes Next, we wanted to detect BMP-6 protein in normal B-cells and tested various commercially available antibodies.
T93 11380-11506 Sentence denotes However, in our hands these anti-BMP-6 antibodies did only recognize the recombinant BMP-6 protein and not the native protein.
T94 11508-11518 Sentence denotes Discussion
T95 11519-11762 Sentence denotes Recent studies have demonstrated an important role for BMP superfamily members in hematopoietic stem cells, early thymocytes [6,7] and B-cell malignancies [8,11,12], but a role for BMPs in normal human B cells has previously not been reported.
T96 11763-11876 Sentence denotes The present study demonstrated a significant antiproliferative effect of BMP-6 in peripheral blood CD19+ B cells.
T97 11877-11991 Sentence denotes Additionally, BMP-6 induced cell death in CD27+ memory B cells as well as in a Burkitt lymphoma cell line (Ramos).
T98 11992-12077 Sentence denotes Importantly, BMP-6 induced a rapid and marked increase in Smad-1/5/8 phosphorylation.
T99 12078-12210 Sentence denotes Furthermore, the BMP-6 induced Smad phosphorylation was followed by a selective upregulation of Id1 mRNA and subsequent Id1 protein.
T100 12211-12347 Sentence denotes In the present study, the demonstrated antiproliferative effect of BMP-6 in anti-IgM treated B cells was significant and dose-dependent.
T101 12348-12474 Sentence denotes Importantly, the anti-proliferative effect of BMP-6 could be completely neutralized by the use of a natural inhibitor, Noggin.
T102 12475-12567 Sentence denotes This is in line with others, showing that Noggin can function as a BMP-6 antagonist [21,22].
T103 12568-12723 Sentence denotes In addition, the combination of soluble BMP-RIB-Fc and BMP-RII-Fc fusion proteins also neutralized the anti-proliferative effect of BMP-6 in human B cells.
T104 12724-12830 Sentence denotes Interestingly, as for other TGF family members, bifunctional effects have also been demonstrated for BMPs.
T105 12831-13084 Sentence denotes Whereas several of the BMPs have been shown to promote proliferation in various cell types including condrocytes [23], liver [24] and granulosa cells [25], antiproliferative effects and induction of apoptosis has been reported for B and T lineage cells.
T106 13085-13237 Sentence denotes Similar effects as demonstrated for BMP-6 on human B cells in the present study, were demonstrated for BMP-2, 4, 6 and -7 in human myeloma cells [9-11].
T107 13238-13355 Sentence denotes Other members of the BMP-family have also been reported to induce apoptosis, including in mouse B lineage cells [26].
T108 13356-13413 Sentence denotes Additionally, BMP-4 inhibits thymocyte proliferation [6].
T109 13414-13550 Sentence denotes Taken together, these data suggest that the role of BMPs in the regulation of proliferation and apoptosis is highly cell type dependent.
T110 13551-13675 Sentence denotes To examine how BMP-6 exerts its functional effects in B cells, we analysed BMP receptor expression by western blot analysis.
T111 13676-13885 Sentence denotes Human peripheral B cells were found to express the BMP type I receptors Act-RIA and BMP-RIB, and the type II-receptors BMP-RII and Act-RIIb, which signal after binding of several BMPs, including BMP-6 [16,13].
T112 13886-13974 Sentence denotes To further explore BMP-6 induced signalling, activation of several pathways is possible.
T113 13975-14052 Sentence denotes The major signalling pathway known to date, is activation of R-Smads [13,27].
T114 14053-14183 Sentence denotes In that respect, BMPs have been shown to exert antiproliferative effects in B lineage cells via phosphorylation of R-Smad [11,28].
T115 14184-14269 Sentence denotes Furthermore, BMP-2 has been shown to induce activation of STAT3 in myeloma cells [9].
T116 14270-14340 Sentence denotes However, phosphorylation of R-Smad was not investigated in that study.
T117 14341-14405 Sentence denotes BMP-2 has also been shown to induce phosphorylation of p38 [29].
T118 14406-14603 Sentence denotes Thus, phosphorylation of p38, STAT3 and Smad1/5/8 represent important BMP-signalling pathways that mediated the effects of BMPs and even cross-talk between these pathways has been reported [29,30].
T119 14604-14749 Sentence denotes In the present study, we were not able to detect BMP-6-induced changes in the phosphorylation status of STAT3 or p38 in human peripheral B cells.
T120 14750-14820 Sentence denotes Instead, a rapid and marked phosphorylation of Smad1/5/8 was revealed.
T121 14821-14953 Sentence denotes In a parallel study, we have found that other BMPs also induced phosphorylation of Smad1/5/8 in peripheral B cells (data not shown).
T122 14954-15120 Sentence denotes We are currently pursuing microarray studies to identify the signalling pathways and target genes that are differently regulated by the various BMPs in human B cells.
T123 15121-15338 Sentence denotes Upregulation of Id1 via Smad1/5/8 phosphorylation is a known mechanism for BMP-6 signalling in other cell systems [31,32] and regulation of Id-proteins is thought to be an important mechanism for Smad-signalling [17].
T124 15339-15514 Sentence denotes In the present study, real-time RT-PCR experiments revealed a specific four-fold upregulation for Id1 in BMP-6-treated B cells, while the amount of Id2–Id4 remained unchanged.
T125 15515-15672 Sentence denotes In agreement with this, western blot analysis demonstrated an upregulation of Id1 protein, while the amount of Id2 and Id3 protein levels remained unchanged.
T126 15673-15875 Sentence denotes Previously, Id1 has been considered not to be expressed in later developmental stages than pro-B cells [33,34], and its constitutive expression has been reported to impair mouse B cell development [35].
T127 15876-16021 Sentence denotes Therefore, our demonstration of the time-dependent upregulation of Id1 mRNA and protein in mature normal human B cells is of particular interest.
T128 16022-16180 Sentence denotes In that respect, it is noteworthy that TGF-β signalling in early and mature B cells induces both Id2 and Id3 expression [36,37], but not Id1 (data not shown).
T129 16181-16289 Sentence denotes Interestingly, these results show that various members of the TGF-β family regulate Id proteins differently.
T130 16290-16379 Sentence denotes Id2 and Id3 are considered to be the Id proteins mainly expressed in mature B cells [38].
T131 16380-16496 Sentence denotes The present study also found Id2 and Id3 protein in B cells to be more highly expressed than Id1 in resting B cells.
T132 16497-16588 Sentence denotes However, BMP-6 did not induce significant changes in the protein expression of Id2 and Id3.
T133 16589-16699 Sentence denotes It is believed that Id proteins block differentiation and promote proliferation in various cell types [39,33].
T134 16700-16850 Sentence denotes Id proteins act as dominant-negative inhibitors of E-proteins and Pax5 function by forming dimers with these proteins, making them unable to bind DNA.
T135 16851-16983 Sentence denotes It has been proposed that the balance among E-proteins, Pax5 and Id proteins might have an important role in activated B cells [38].
T136 16984-17149 Sentence denotes In that respect, E-proteins have been implicated in both the promotion and inhibition of cell survival and growth at different points in lymphocyte development [40].
T137 17150-17419 Sentence denotes The antiproliferative and death inducing effect of BMP-6 in B cells with concomitant upregulation of Id1 protein is therefore in line with the view that Id proteins are required for the induction of growth arrest and apoptosis in B-lymphocyte progenitors by TGF-β [40].
T138 17420-17556 Sentence denotes Furthermore, Id proteins are known as important parts of signalling pathways involved in development, cell cycle and tumorigenesis [32].
T139 17557-17817 Sentence denotes It is well established that various members of the Id family are overexpressed in a range of human tumours and generally, Id1 appears to be the family member most widely overexpressed in a variety of human malignancies [41], including multiple myeloma [42,32].
T140 17818-18000 Sentence denotes Additionally, our findings that BMP-6 activates intracellular signalling pathways in human B cells might be of potential pathophysiological significance in lymphoma and inflammation.
T141 18001-18094 Sentence denotes High BMP-6 mRNA expression in DLBCL has been shown to correlate to unfavourable outcome [12].
T142 18095-18291 Sentence denotes In this respect, it is of interest that targeted expression of Id1 to B-lymphocytes resulted in aberrant B cell development, massive apoptosis, and subsequent development of B cell lymphomas [35].
T143 18292-18465 Sentence denotes Moreover, BMP-6 has been suggested to play a role in rheumatoid arthritis (RA) [43,44] and elevated levels of Id1 and Id3 have been found in the synovia of RA-patients [45].
T144 18466-18626 Sentence denotes Altogether, these results point to an important role for Id proteins in the regulation of normal B cell homeostasis and in diseases, where B cells are involved.
T145 18627-18780 Sentence denotes It will therefore be important to further elucidate the role of Id-1 in human B cells by selective over expression or inhibition of Id-1 gene expression.
T146 18781-19021 Sentence denotes Given the role of BMP-6 in mature human B cells demonstrated here, identification of BMP-6 producing cells in vivo with possibility of interaction with naïve and memory B cells might contribute to the understanding of mature B cell biology.
T147 19022-19110 Sentence denotes High BMP-6 mRNA expression in DLBCL has been detected by gene expression profiling [12].
T148 19111-19215 Sentence denotes Furthermore, production of BMP-6 transcripts in normal activated B cells was detected in the same study.
T149 19216-19323 Sentence denotes Of note, an autocrine BMP-6 loop has been reported by others in chondrocytes and in the ovarium [46,19,18].
T150 19324-19417 Sentence denotes Therefore, we wanted to explore the possibility for an autocrine BMP-6 loop in human B cells.
T151 19418-19642 Sentence denotes We analysed the expression BMP-6 mRNA in peripheral blood B cells by real-time PCR, and report here the upregulation of endogenous BMP-6 transcripts after stimulation with FCS, human AB-serum and, most importantly, anti-IgM.
T152 19643-19865 Sentence denotes However, our attempts to study BMP-6 protein levels were unsuccessful due to problems with unspecific binding of the anti-BMP-6 antibodies tested, and lack of specific staining in control cells known to express BMP-6 mRNA.
T153 19866-19924 Sentence denotes In contrast, the recombinant protein was readily detected.
T154 19925-20035 Sentence denotes In that respect, few investigators have detected BMP-6 protein in humans, especially in non-pathogenic tissue.
T155 20036-20245 Sentence denotes The possibility of BMP-6 production in human B-cells is in line with a recent work that reported the production of BMP-6 in mouse B cells, infiltrating the bone marrow of mice with inflammatory arthritis [43].
T156 20246-20333 Sentence denotes In this study, a role for BMPs in the inflammatoric process of arthritis was suggested.
T157 20334-20436 Sentence denotes The upregulation of the BMP-6-transcripts after IgM-crosslinking is of pathophysiologic interest [12].
T158 20437-20616 Sentence denotes A loss of TGF-β-responsiveness has been suggested to be a critical contribution to malignant transformation [47,48] and similar oncogenic mechanisms have been postulated for BMPs.
T159 20617-20773 Sentence denotes Lines of evidence suggest [49] that at early stages of carcinogenesis, BMP-6 is not a tumour promoter, but suppresses benign and malignant tumour outgrowth.
T160 20774-20997 Sentence denotes These findings are in good agreement with previous findings for other TGF-β family members, including TGF-β1 and BMP-4 [50], indicating that cellular context of the BMP target cell might define the various observed effects.
T161 20998-21298 Sentence denotes In contrast to the upregulation of BMP-6 transcript in B cells, we were not able to detect BMP-6 transcripts in human peripheral blood CD4+ or CD8+ T cells (resting or stimulated with anti-CD3 and anti-CD28; data not shown), consistent with the findings in T cell lines [20] and T cells in mice [43].
T162 21299-21449 Sentence denotes Other potential BMP-6 sources for mature B cells in vivo might be other cells of the immune system or tissue with contact to the hematopoietic system.
T163 21450-21546 Sentence denotes One well recognized source for BMP-6 production is the human bone and bone marrow stroma [51,8].
T164 21547-21726 Sentence denotes Furthermore, it is noteworthy that human umbilical vein endothelial cells (HUVEC) highly express BMP-6 mRNA [52], and vascular endothelium has been reported to produce BMP-6 [53].
T165 21727-21811 Sentence denotes These studies might imply a role for BMP-6 in transendothelial migration of B cells.
T166 21812-21901 Sentence denotes BMP-6 mRNA has been demonstrated in murine macrophage cell lines, but not in humans [54].
T167 21902-22060 Sentence denotes In accordance with these findings, other human cell lines of neutrophil and monocytic origin have been described to be negative for the BMP-6 transcript [20].
T168 22061-22156 Sentence denotes To our knowledge, there is currently no report about BMP-6 production of human dendritic cells.
T169 22158-22168 Sentence denotes Conclusion
T170 22169-22331 Sentence denotes In conclusion, our results show that BMP-6 induces activation of intracellular Smad signalling in mature human B-cells with consecutive production of Id1 protein.
T171 22332-22485 Sentence denotes Furthermore, we report that BMP-6 has an antiproliferative effect in B cells stimulated with anti-IgM alone or the combined action of anti-IgM and CD40L.
T172 22486-22569 Sentence denotes Additionally, BMP-6 induces cell death in activated memory B cells and Ramos cells.
T173 22570-22779 Sentence denotes Taken together, these results provide a rationale to further examine the role of BMP-6 signalling in normal B cell biology as well as in pathologic conditions like B cell malignancies and autoimmune disorders.
T174 22781-22788 Sentence denotes Methods
T175 22790-22802 Sentence denotes Cell culture
T176 22803-22937 Sentence denotes If not specified, all cells were cultured in X-VIVO 15™ (BioWhittaker, Verviers, Belgium) serum-free medium at 37°C and 5% CO2 in air.
T177 22938-23101 Sentence denotes Peripheral blood was provided by the Blood Bank at Buskerud Regional Hospital with formal agreement by the patients, and approval by the regional ethics committee.
T178 23102-23295 Sentence denotes Highly purified resting human B-lymphocytes (CD19+ cells) were isolated from the peripheral blood by rosetting with immunomagnetic beads (Dynabeads M450; Dynal, Oslo, Norway) as described [55].
T179 23296-23426 Sentence denotes This procedure yields less than 0.5% T cells, 0.1% NK cells, and 0.5% monocytes as judged by indirect immunofluorescence staining.
T180 23427-23842 Sentence denotes The following cell lines from human lymphoid malignancies were maintained in RPMI 1640 (PAA Laboratories GmbH, Pasching, Austria) supplemented with 10% foetal bovine serum (FCS), 100 units/ml penicillin G, and 100 units/ml of streptomycin sulphate, but serum-starved for at least four hours and cultured in X-VIVO 15™ when included in experiments: EBV-negative BL cell lines Ramos (ECACC 85030802), HL60 (JCRB0085).
T181 23844-23870 Sentence denotes Growth factors/supplements
T182 23871-24385 Sentence denotes The following reagents were used at indicated concentrations: recombinant human (rhu) BMP-6 (1 μg/ml, if not specified otherwise), rhu BMP-RIB/ALK-6/Fc Chimera (5 μg/ml), rhu BMPR-II/Fc Chimera (5 μg/ml), and recombinant mouse Noggin (5 μg/ml) were purchased from R&D Systems (Abingdon, UK); Anti-IgM F(ab)2 fragments of rabbit polyclonal antibodies to human IgM heavy chain (37.5 μg/ml) was obtained from Dako, Copenhagen, Denmark and rhu CD40 ligand (CD40L, 10 ng/ml) was a gift from Immunex Corp. (Seattle, WA).
T183 24387-24455 Sentence denotes Antibodies used for flow cytometric analysis and immunoblot analysis
T184 24456-24597 Sentence denotes Antibodies against the human BMP-receptors Act-RIA, BMP-RIB, BMPR-II, Act-RIIA and Act-RIIb were purchased from R & D Systems (Abingdon, UK).
T185 24598-24910 Sentence denotes Detection of the BMP-6-protein has been tried with the following antibodies: goat polyclonal anti-BMP-6 (Santa Cruz, San Diego, CA, USA), monoclonal mouse anti-BMP-6 and polyclonal goat anti-BMP-6 from R & D Systems (Abingdon, UK), and mouse monoclonal anti-BMP-6 (Chemicon International Inc, Temecula, CA, USA).
T186 24911-25055 Sentence denotes Characterisation of BMP-signalling pathways was done by use of anti-phospho-Smad1, -5, -and 8 polyclonal antibody (Chemicon, Temecula, CA, USA).
T187 25056-25249 Sentence denotes Expression levels of Id1–3 proteins were detected with polyclonal rabbit antibody and detection was blocked with blocking peptide from Santa Cruz Biotechnology (Santa Cruz, San Diego, CA, USA).
T188 25250-25421 Sentence denotes As secondary antibodies served anti-mouse, anti-goat or anti-rabbit IgG- horseradish peroxidase (HRP) from Dakocytomation AS (Copenhagen, Denmark) for immunoblot analysis.
T189 25422-25455 Sentence denotes Anti-β-actin was from Santa-Cruz.
T190 25456-25536 Sentence denotes From Becton Dickinson (San Jose, CA), we purchased anti-CD19-PE, anti-CD19-FITC.
T191 25537-25716 Sentence denotes The antibodies used for cell sorting were anti-CD19 PC5 from Immunotech SA (Marseille, France) and anti-CD27 PE from Becton Dickinson, Biosciences Pharmingen (San Diego, CA, USA).
T192 25718-25730 Sentence denotes Cell sorting
T193 25731-25951 Sentence denotes Highly purified CD19+CD27- or CD19+CD27+ cells were obtained by staining CD19+ cells with anti-CD27 PE and CD19 PC5 mAbs for 30 minutes at 4°C, followed by washing with PBS and sorting on FACS DiVa from Becton Dickinson.
T194 25953-25974 Sentence denotes Western-blot analysis
T195 25975-26161 Sentence denotes B cells from peripheral blood or cultured cell-lines were lysed in lysis buffer (glycerol 10%, β-mercaptoethanol 5%, 0.0625 M Tris-HCL [pH 6.8], sodium dodecyl sulphate [SDS] 2.5%w/vol).
T196 26162-26355 Sentence denotes Total protein (30–100 μg) from each sample was run on 10% or 12% SDS/polyacrylamide (SDS/PAGE) gels and blotted onto nitrocellulose filters (Protran; Schleicher &Schuell GmbH, Dassel, Germany).
T197 26356-26505 Sentence denotes Blocking, washing and incubation of the filters with primary antibodies were done according to the manufacturer's protocols at room temperature (RT).
T198 26506-26687 Sentence denotes After washing with TBS/0.1% Tween-20 (TBS-T), the filters were incubated with horseradish peroxidase (HRP) coupled to relevant secondary antibodies (see above) for 60 minutes at RT.
T199 26688-26802 Sentence denotes Enzyme activity was visualised by the enhanced chemiluminescence system, ECL+PLUS (Amersham, Buckinghamshire, UK).
T200 26803-26929 Sentence denotes Densitometric analysis was performed by scanning hyperfilms on a Personal Densitometer SI (Molecular Dynamics, Sunnyvale, CA).
T201 26930-27093 Sentence denotes Quantification of Id1, Id2 and Id3 protein was calculated by normalizing the specific protein bands to β-actin using Image Quant 5.5 software (Molecular Dynamics).
T202 27095-27144 Sentence denotes Analysis of BMP-6 messenger RNA (mRNA) expression
T203 27145-27249 Sentence denotes Endogenous expression of the BMP-6 gene was examined by reverse transcription-polymerase chain reaction.
T204 27250-27402 Sentence denotes Total RNA was isolated using Absolutely RNA™ RT-PCR Miniprep Kit (Stratagene Europe, Amsterdam, Netherland) according to the manufacturers instructions.
T205 27403-27504 Sentence denotes Quantification of the isolated total RNA was achieved by using spectrophotometric OD260 measurements.
T206 27505-27653 Sentence denotes Equal amounts of RNA were then reverse transcribed to cDNA with TaqMan® Reverse Transcription Reagents (Applied Biosystems, Foster City, CA, U.S.A).
T207 27654-27762 Sentence denotes To measure mRNA expression of BMP6, Id1–Id4 and PGK1 PCR were carried out with TaqMan® universal master mix.
T208 27763-27836 Sentence denotes Primers and probes were provided by Assay-on-Demand (Applied Biosystems).
T209 27837-27918 Sentence denotes PCR reactions were carried out in a final volume of 25 μl (BMP-6) or 20 μl (ID1).
T210 27919-28001 Sentence denotes The cDNA added to each reaction was equivalent to the input of 20 ng of total RNA.
T211 28002-28173 Sentence denotes The gene expression was quantified using the standard curve method (BMP6), or the comparative CT method (Id1) as described in ABI7700 User Bulletin 2 (Applied Biosystems).
T212 28174-28241 Sentence denotes The expression was then normalized to the expression level of PGK1.
T213 28242-28352 Sentence denotes PGK1 was chosen, because it has been shown to have low expression variability among lymphocyte specimens [56].
T214 28353-28440 Sentence denotes Expression levels in B cells were then related to the expression levels in Ramos cells.
T215 28442-28460 Sentence denotes Cell proliferation
T216 28461-28617 Sentence denotes For estimation of DNA synthesis, CD19+ cells (7.5 × 104 cells/0.2 ml) or Ramos cells (1 × 104 cells/0.2 ml) were cultured in triplicate in microtiter wells.
T217 28618-28742 Sentence denotes The cells were pulsed with 3.7 × 104Bq [3H]thymidine (Amersham, Buckinghamshire, UK) for the last 16 h of a 72-h incubation.
T218 28743-28980 Sentence denotes The cells were harvested using an automated cell harvester (Packard Instrument Company, Meriden, CT, USA) and [3H]thymidine incorporation was determined in a scintillation counter (TopCount, Packard Instrument Company Inc., Meriden, CT).
T219 28982-29009 Sentence denotes Determination of cell death
T220 29010-29180 Sentence denotes Cell death was measured by vital dye exclusion test by staining cells with 5 μg/ml propidium iodide ([PI]; Calbiochem Corp.; La Jolla, CA; 5 mg/ml) for one minute on ice.
T221 29181-29257 Sentence denotes At least 1,000 cells per sample were run on a BD FACSCalibur flow cytometer.
T222 29259-29279 Sentence denotes Statistical analysis
T223 29280-29471 Sentence denotes The statistical significance of differences between groups was determined using the paired two-tailed Wilcoxon nonparametric test, by applying SPSS10.1 software (SPSS Inc., Chicago, IL, USA).
T224 29472-29524 Sentence denotes P values less than 0.05 were considered significant.
T225 29526-29547 Sentence denotes List of abbreviations
T226 29548-29579 Sentence denotes BMP, Bone morphogenetic protein
T227 29580-29616 Sentence denotes DLBCL, diffuse large B cell lymphoma
T228 29617-29645 Sentence denotes Id, inhibitor of dna binding
T229 29646-29765 Sentence denotes Smad, the name Smad originates from the Drosophila protein, MAD and the Caenorhabditis elegans proteins, sma-2, 3 and 4
T230 29766-29820 Sentence denotes STAT, signal transducer and activator of transcription
T231 29822-29844 Sentence denotes Authors' contributions
T232 29845-29918 Sentence denotes CK designed and conducted experiments, oversaw research, and wrote paper.
T233 29919-29976 Sentence denotes EAS designed and conducted experiments, oversaw research.
T234 29977-30034 Sentence denotes MEH designed and conducted experiments, oversaw research.
T235 30035-30073 Sentence denotes LF designed and conducted experiments.
T236 30074-30134 Sentence denotes EBS designed experiments, oversaw research, and wrote paper.
T237 30135-30209 Sentence denotes JHM designed and conducted experiments, oversaw research, and wrote paper.

ICD10

Id Subject Object Predicate Lexical cue
T2218 2644-2660 http://purl.bioontology.org/ontology/ICD10/C90.0 denotes multiple myeloma
T12302 17792-17808 http://purl.bioontology.org/ontology/ICD10/C90.0 denotes multiple myeloma
T12303 18345-18365 http://purl.bioontology.org/ontology/ICD10/M06.9 denotes rheumatoid arthritis
T12304 18356-18365 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T12305 20230-20239 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T12306 20309-20318 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T885 841-845 Protein denotes CD19
T886 846-850 Protein denotes CD27
T887 873-877 Protein denotes CD19
T888 878-882 Protein denotes CD27
T889 955-960 Protein denotes CD40L
T890 976-981 Protein denotes BMP-6
T891 1075-1080 Protein denotes BMP-6
T892 1146-1152 Protein denotes noggin
T893 1196-1206 Positive_regulation denotes upregulate
T894 1207-1212 Protein denotes BMP-6
T895 1287-1292 Protein denotes BMP-6
T896 1328-1335 Positive_regulation denotes induced
T897 1328-1335 Positive_regulation denotes induced
T898 1328-1335 Positive_regulation denotes induced
T899 1336-1351 Phosphorylation denotes phosphorylation
T900 1336-1351 Phosphorylation denotes phosphorylation
T901 1336-1351 Phosphorylation denotes phosphorylation
T902 1355-1360 Protein denotes Smad1
T903 1361-1362 Protein denotes 5
T904 1363-1364 Protein denotes 8
T905 1365-1373 Positive_regulation denotes followed
T906 1365-1373 Positive_regulation denotes followed
T907 1365-1373 Positive_regulation denotes followed
T908 1380-1392 Positive_regulation denotes upregulation
T909 1396-1399 Protein denotes Id1
T2424 1429-1457 Protein denotes transforming growth factor β
T2425 1459-1464 Protein denotes TGF-β
T2426 1635-1640 Protein denotes TGF-β
T2427 2042-2047 Protein denotes TGF-β
T2428 2307-2313 Protein denotes BMP- 2
T2429 2315-2317 Protein denotes -4
T2430 2322-2324 Protein denotes -7
T2431 2436-2441 Protein denotes BMP-6
T2432 2570-2575 Protein denotes BMP-2
T2433 2577-2579 Protein denotes -4
T2434 2581-2582 Protein denotes 6
T2435 2587-2589 Protein denotes -7
T2436 2718-2723 Protein denotes BMP-6
T2437 2738-2747 Positive_regulation denotes increased
T2438 2888-2893 Protein denotes BMP-6
T2439 2939-2947 Binding denotes ligation
T2440 2952-2969 Binding denotes heterodimerzation
T2441 3145-3150 Protein denotes BMP-6
T2442 3174-3182 Binding denotes ligation
T2443 3174-3182 Binding denotes ligation
T2444 3174-3182 Binding denotes ligation
T2445 3174-3182 Binding denotes ligation
T2446 3174-3182 Binding denotes ligation
T2447 3174-3182 Binding denotes ligation
T2448 3207-3214 Protein denotes Act-RIA
T2449 3216-3223 Protein denotes BMP-RIA
T2450 3229-3236 Protein denotes BMP-RIB
T2451 3263-3270 Protein denotes BMP-RII
T2452 3272-3280 Protein denotes Act-RIIA
T2453 3285-3293 Protein denotes Act-RIIB
T2454 3301-3305 Positive_regulation denotes lead
T2455 3301-3305 Positive_regulation denotes lead
T2456 3301-3305 Positive_regulation denotes lead
T2457 3301-3305 Positive_regulation denotes lead
T2458 3301-3305 Positive_regulation denotes lead
T2459 3301-3305 Positive_regulation denotes lead
T2460 3301-3305 Positive_regulation denotes lead
T2461 3301-3305 Positive_regulation denotes lead
T2462 3301-3305 Positive_regulation denotes lead
T2463 3301-3305 Positive_regulation denotes lead
T2464 3301-3305 Positive_regulation denotes lead
T2465 3301-3305 Positive_regulation denotes lead
T2466 3301-3305 Positive_regulation denotes lead
T2467 3301-3305 Positive_regulation denotes lead
T2468 3301-3305 Positive_regulation denotes lead
T2469 3301-3305 Positive_regulation denotes lead
T2470 3301-3305 Positive_regulation denotes lead
T2471 3301-3305 Positive_regulation denotes lead
T2472 3313-3328 Phosphorylation denotes phosphorylation
T2473 3313-3328 Phosphorylation denotes phosphorylation
T2474 3313-3328 Phosphorylation denotes phosphorylation
T2475 3352-3358 Protein denotes Smad-1
T2476 3360-3366 Protein denotes Smad-5
T2477 3372-3378 Protein denotes Smad-8
T2478 3399-3413 Binding denotes form complexes
T2479 3399-3413 Binding denotes form complexes
T2480 3399-3413 Binding denotes form complexes
T2481 3432-3437 Protein denotes Smad4
T2482 3447-3459 Localization denotes translocated
T2483 3447-3459 Localization denotes translocated
T2484 3447-3459 Localization denotes translocated
T2485 3469-3476 Entity denotes nucleus
T2486 3545-3550 Protein denotes BMP-6
T2487 3702-3707 Protein denotes BMP-6
T2488 3791-3801 Gene_expression denotes expression
T2489 3823-3828 Protein denotes BMP-6
T2490 3829-3836 Positive_regulation denotes induced
T2491 3829-3836 Positive_regulation denotes induced
T2492 3895-3905 Regulation denotes regulation
T2493 3895-3905 Regulation denotes regulation
T2494 3926-3929 Protein denotes Id1
T2495 3930-3933 Protein denotes Id4
T2496 4012-4021 Gene_expression denotes producing true
T2497 4022-4027 Protein denotes BMP-6
T3510 4039-4044 Protein denotes BMP-6
T3511 4117-4122 Protein denotes BMP-6
T3512 4210-4215 Protein denotes BMP-6
T3513 4416-4421 Protein denotes BMP-6
T3514 4509-4514 Protein denotes CD40L
T3515 4545-4550 Protein denotes BMP-6
T3516 4581-4586 Protein denotes BMP-6
T3517 4750-4755 Protein denotes CD40L
T3518 4800-4805 Protein denotes BMP-6
T3519 4990-4995 Protein denotes BMP-6
T3520 5065-5071 Protein denotes Noggin
T3521 5139-5146 Protein denotes BMP-RIB
T3522 5154-5161 Protein denotes BMP-RII
T3523 5197-5202 Protein denotes BMP-6
T3524 5253-5258 Protein denotes BMP-6
T3525 5316-5320 Protein denotes CD19
T3526 5321-5325 Protein denotes CD27
T3527 5340-5344 Protein denotes CD19
T3528 5345-5349 Protein denotes CD27
T3529 5435-5439 Protein denotes CD19
T3530 5519-5524 Protein denotes BMP-6
T3531 5535-5540 Protein denotes BMP-6
T3979 5772-5777 Protein denotes BMP-6
T3980 5874-5879 Protein denotes BMP-6
T3981 6025-6030 Protein denotes BMP-6
T3982 6060-6065 Protein denotes BMP-6
T3983 6184-6188 Protein denotes CD27
T3984 6318-6323 Protein denotes BMP-6
T3985 6368-6372 Protein denotes CD19
T3986 6417-6421 Protein denotes CD27
T4471 6524-6529 Protein denotes BMP-6
T4472 6824-6831 Protein denotes Act-RIA
T4473 6833-6840 Protein denotes BMP-RIB
T4474 6867-6874 Protein denotes BMP-RII
T4475 6879-6887 Protein denotes Act-RIIb
T4476 6892-6901 Gene_expression denotes expressed
T4477 6892-6901 Gene_expression denotes expressed
T4478 6892-6901 Gene_expression denotes expressed
T4479 6892-6901 Gene_expression denotes expressed
T4480 6951-6960 Gene_expression denotes expressed
T4481 6951-6960 Gene_expression denotes expressed
T4482 6951-6960 Gene_expression denotes expressed
T4483 6982-6989 Protein denotes Act-RIA
T4484 6998-7005 Protein denotes BMP-RIB
T4485 7031-7038 Protein denotes BMP-RII
T4486 7135-7144 Gene_expression denotes expressed
T4487 7135-7144 Gene_expression denotes expressed
T4488 7145-7152 Protein denotes Act-RIA
T4489 7157-7164 Protein denotes BMP-RII
T4490 7292-7296 Binding denotes bind
T4491 7297-7302 Protein denotes BMP-6
T5222 7310-7315 Protein denotes BMP-6
T5223 7316-7323 Positive_regulation denotes induces
T5224 7316-7323 Positive_regulation denotes induces
T5225 7316-7323 Positive_regulation denotes induces
T5226 7324-7339 Phosphorylation denotes phosphorylation
T5227 7324-7339 Phosphorylation denotes phosphorylation
T5228 7324-7339 Phosphorylation denotes phosphorylation
T5229 7343-7348 Protein denotes Smad1
T5230 7349-7350 Protein denotes 5
T5231 7351-7352 Protein denotes 8
T5232 7526-7531 Protein denotes BMP-6
T5233 7720-7725 Protein denotes BMP-6
T5234 7811-7825 Phosphorylation denotes phosphorylated true
T5235 7811-7825 Phosphorylation denotes phosphorylated true
T5236 7811-7825 Phosphorylation denotes phosphorylated true
T5237 7835-7840 Protein denotes Smad1
T5238 7841-7842 Protein denotes 5
T5239 7843-7844 Protein denotes 8
T5240 7927-7932 Protein denotes BMP-6
T5241 7933-7940 Positive_regulation denotes induced
T5242 7933-7940 Positive_regulation denotes induced
T5243 7933-7940 Positive_regulation denotes induced
T5244 7941-7956 Phosphorylation denotes phosphorylation
T5245 7941-7956 Phosphorylation denotes phosphorylation
T5246 7941-7956 Phosphorylation denotes phosphorylation
T5247 7970-7975 Protein denotes BMP-6
T5248 7976-7983 Positive_regulation denotes induced
T5249 7976-7983 Positive_regulation denotes induced
T5250 7976-7983 Positive_regulation denotes induced
T5251 7984-7999 Phosphorylation denotes phosphorylation
T5252 7984-7999 Phosphorylation denotes phosphorylation
T5253 7984-7999 Phosphorylation denotes phosphorylation
T5254 8280-8285 Protein denotes BMP-6
T5255 8308-8313 Protein denotes BMP-6
T5256 8376-8383 Regulation denotes changes true
T5257 8376-8383 Regulation denotes changes true
T5258 8400-8407 Phosphorylation denotes phospho
T5259 8408-8413 Protein denotes STAT3
T5260 8417-8424 Phosphorylation denotes phospho
T5261 8425-8428 Protein denotes p38
T5262 8434-8439 Protein denotes BMP-6
T6327 8480-8485 Protein denotes BMP-6
T6328 8486-8493 Positive_regulation denotes induces
T6329 8494-8506 Positive_regulation denotes upregulation
T6330 8510-8513 Protein denotes Id1
T6331 8553-8558 Protein denotes BMP-6
T6332 8559-8566 Positive_regulation denotes induced
T6333 8559-8566 Positive_regulation denotes induced
T6334 8559-8566 Positive_regulation denotes induced
T6335 8567-8582 Phosphorylation denotes phosphorylation
T6336 8567-8582 Phosphorylation denotes phosphorylation
T6337 8567-8582 Phosphorylation denotes phosphorylation
T6338 8586-8592 Protein denotes Smad 1
T6339 8593-8594 Protein denotes 5
T6340 8595-8596 Protein denotes 8
T6341 8909-8914 Protein denotes BMP-6
T6342 8986-8989 Protein denotes Id1
T6343 8990-8993 Protein denotes Id4
T6344 9083-9095 Positive_regulation denotes upregulation
T6345 9099-9102 Protein denotes Id1
T6346 9111-9116 Protein denotes BMP-6
T6347 9149-9162 Positive_regulation denotes up-regulation
T6348 9166-9169 Protein denotes Id1
T6349 9235-9247 Positive_regulation denotes upregulation
T6350 9280-9285 Protein denotes BMP-6
T6351 9355-9362 Regulation denotes changes true
T6352 9355-9362 Regulation denotes changes true
T6353 9381-9384 Protein denotes Id2
T6354 9389-9392 Protein denotes Id3
T6355 9407-9410 Protein denotes Id4
T6356 9432-9442 Positive_regulation denotes detectable true
T6357 9511-9516 Protein denotes BMP-6
T6358 9517-9524 Positive_regulation denotes induced
T6359 9525-9537 Positive_regulation denotes upregulation
T6360 9541-9544 Protein denotes Id1
T6361 9559-9569 Positive_regulation denotes correlated
T6362 9575-9587 Positive_regulation denotes upregulation
T6363 9591-9594 Protein denotes Id1
T6364 9616-9624 Positive_regulation denotes increase
T6365 9628-9631 Protein denotes Id1
T6366 9680-9689 Positive_regulation denotes increased
T6367 9711-9716 Protein denotes BMP-6
T6368 9745-9757 Positive_regulation denotes upregulation
T6369 9854-9860 Regulation denotes change true
T6370 9854-9860 Regulation denotes change true
T6371 9868-9875 Gene_expression denotes amounts
T6372 9868-9875 Gene_expression denotes amounts
T6373 9879-9882 Protein denotes Id2
T6374 9887-9890 Protein denotes Id3
T6375 9951-9956 Negative_regulation denotes block
T6376 9961-9964 Protein denotes Id1
T6377 10061-10064 Protein denotes Id1
T6378 10126-10131 Protein denotes BMP-6
T6379 10158-10161 Protein denotes Id2
T6380 10166-10169 Protein denotes Id3
T7087 10196-10201 Protein denotes BMP-6
T7088 10202-10212 Gene_expression denotes production
T7089 10238-10243 Protein denotes BMP-6
T7090 10397-10404 Gene_expression denotes produce true
T7091 10405-10410 Protein denotes BMP-6
T7092 10471-10478 Transcription denotes express
T7093 10479-10484 Protein denotes BMP-6
T7094 10604-10609 Protein denotes BMP-6
T7095 10754-10767 Positive_regulation denotes up-regulation
T7096 10771-10776 Protein denotes BMP-6
T7097 10857-10869 Positive_regulation denotes upregulation
T7098 10926-10931 Protein denotes BMP-6
T7099 10941-10957 Negative_regulation denotes back to baseline
T7100 11044-11051 Positive_regulation denotes induced
T7101 11064-11076 Positive_regulation denotes upregulation
T7102 11080-11085 Protein denotes BMP-6
T7103 11186-11193 Transcription denotes express true
T7104 11194-11199 Protein denotes BMP-6
T7105 11294-11299 Protein denotes BMP-6
T7106 11413-11418 Protein denotes BMP-6
T7107 11439-11448 Binding denotes recognize true
T7108 11465-11470 Protein denotes BMP-6
T12962 11836-11841 Protein denotes BMP-6
T12963 11862-11866 Protein denotes CD19
T12964 11891-11896 Protein denotes BMP-6
T12965 11919-11923 Protein denotes CD27
T12966 12005-12010 Protein denotes BMP-6
T12967 12011-12018 Positive_regulation denotes induced
T12968 12011-12018 Positive_regulation denotes induced
T12969 12011-12018 Positive_regulation denotes induced
T12970 12038-12046 Positive_regulation denotes increase
T12971 12038-12046 Positive_regulation denotes increase
T12972 12038-12046 Positive_regulation denotes increase
T12973 12050-12056 Protein denotes Smad-1
T12974 12057-12058 Protein denotes 5
T12975 12059-12060 Protein denotes 8
T12976 12061-12076 Phosphorylation denotes phosphorylation
T12977 12061-12076 Phosphorylation denotes phosphorylation
T12978 12061-12076 Phosphorylation denotes phosphorylation
T12979 12095-12100 Protein denotes BMP-6
T12980 12101-12108 Positive_regulation denotes induced
T12981 12109-12113 Protein denotes Smad
T12982 12114-12129 Phosphorylation denotes phosphorylation
T12983 12134-12142 Positive_regulation denotes followed
T12984 12134-12142 Positive_regulation denotes followed
T12985 12158-12170 Positive_regulation denotes upregulation
T12986 12158-12170 Positive_regulation denotes upregulation
T12987 12174-12177 Protein denotes Id1
T12988 12198-12201 Protein denotes Id1
T12989 12278-12283 Protein denotes BMP-6
T12990 12394-12399 Protein denotes BMP-6
T12991 12467-12473 Protein denotes Noggin
T12992 12517-12523 Protein denotes Noggin
T12993 12542-12547 Protein denotes BMP-6
T12994 12548-12558 Negative_regulation denotes antagonist
T12995 12608-12615 Protein denotes BMP-RIB
T12996 12623-12630 Protein denotes BMP-RII
T12997 12700-12705 Protein denotes BMP-6
T12998 13121-13126 Protein denotes BMP-6
T12999 13188-13193 Protein denotes BMP-2
T13000 13195-13196 Protein denotes 4
T13001 13198-13199 Protein denotes 6
T13002 13204-13206 Protein denotes -7
T13003 13370-13375 Protein denotes BMP-4
T13004 13566-13571 Protein denotes BMP-6
T13005 13715-13722 Gene_expression denotes express
T13006 13715-13722 Gene_expression denotes express
T13007 13715-13722 Gene_expression denotes express
T13008 13715-13722 Gene_expression denotes express
T13009 13748-13755 Protein denotes Act-RIA
T13010 13760-13767 Protein denotes BMP-RIB
T13011 13795-13802 Protein denotes BMP-RII
T13012 13807-13815 Protein denotes Act-RIIb
T13013 13836-13843 Binding denotes binding
T13014 13836-13843 Binding denotes binding
T13015 13836-13843 Binding denotes binding
T13016 13836-13843 Binding denotes binding
T13017 13871-13876 Protein denotes BMP-6
T13018 13905-13910 Protein denotes BMP-6
T13019 14197-14202 Protein denotes BMP-2
T13020 14221-14227 Positive_regulation denotes induce
T13021 14228-14238 Positive_regulation denotes activation
T13022 14242-14247 Protein denotes STAT3
T13023 14341-14346 Protein denotes BMP-2
T13024 14412-14427 Phosphorylation denotes phosphorylation
T13025 14412-14427 Phosphorylation denotes phosphorylation
T13026 14412-14427 Phosphorylation denotes phosphorylation
T13027 14412-14427 Phosphorylation denotes phosphorylation
T13028 14436-14441 Protein denotes STAT3
T13029 14446-14451 Protein denotes Smad1
T13030 14452-14453 Protein denotes 5
T13031 14454-14455 Protein denotes 8
T13032 14653-14658 Protein denotes BMP-6
T13033 14659-14666 Positive_regulation denotes induced true
T13034 14667-14674 Regulation denotes changes
T13035 14682-14697 Phosphorylation denotes phosphorylation
T13036 14708-14713 Protein denotes STAT3
T13037 14778-14793 Phosphorylation denotes phosphorylation
T13038 14778-14793 Phosphorylation denotes phosphorylation
T13039 14778-14793 Phosphorylation denotes phosphorylation
T13040 14797-14802 Protein denotes Smad1
T13041 14803-14804 Protein denotes 5
T13042 14805-14806 Protein denotes 8
T13043 14877-14884 Positive_regulation denotes induced
T13044 14877-14884 Positive_regulation denotes induced
T13045 14877-14884 Positive_regulation denotes induced
T13046 14885-14900 Phosphorylation denotes phosphorylation
T13047 14885-14900 Phosphorylation denotes phosphorylation
T13048 14885-14900 Phosphorylation denotes phosphorylation
T13049 14904-14909 Protein denotes Smad1
T13050 14910-14911 Protein denotes 5
T13051 14912-14913 Protein denotes 8
T13052 15121-15133 Positive_regulation denotes Upregulation
T13053 15121-15133 Positive_regulation denotes Upregulation
T13054 15121-15133 Positive_regulation denotes Upregulation
T13055 15137-15140 Protein denotes Id1
T13056 15145-15150 Protein denotes Smad1
T13057 15151-15152 Protein denotes 5
T13058 15153-15154 Protein denotes 8
T13059 15155-15170 Phosphorylation denotes phosphorylation
T13060 15155-15170 Phosphorylation denotes phosphorylation
T13061 15155-15170 Phosphorylation denotes phosphorylation
T13062 15182-15191 Regulation denotes mechanism
T13063 15182-15191 Regulation denotes mechanism
T13064 15182-15191 Regulation denotes mechanism
T13065 15196-15201 Protein denotes BMP-6
T13066 15420-15432 Positive_regulation denotes upregulation
T13067 15437-15440 Protein denotes Id1
T13068 15444-15449 Protein denotes BMP-6
T13069 15477-15483 Gene_expression denotes amount
T13070 15477-15483 Gene_expression denotes amount
T13071 15487-15490 Protein denotes Id2
T13072 15491-15494 Protein denotes Id4
T13073 15495-15513 Positive_regulation denotes remained unchanged true
T13074 15495-15513 Positive_regulation denotes remained unchanged true
T13075 15577-15589 Positive_regulation denotes upregulation
T13076 15593-15596 Protein denotes Id1
T13077 15616-15622 Gene_expression denotes amount
T13078 15616-15622 Gene_expression denotes amount
T13079 15626-15629 Protein denotes Id2
T13080 15634-15637 Protein denotes Id3
T13081 15653-15671 Positive_regulation denotes remained unchanged true
T13082 15653-15671 Positive_regulation denotes remained unchanged true
T13083 15685-15688 Protein denotes Id1
T13084 15719-15728 Gene_expression denotes expressed true true
T13085 15806-15816 Gene_expression denotes expression
T13086 15927-15939 Positive_regulation denotes upregulation
T13087 15943-15946 Protein denotes Id1
T13088 16061-16066 Protein denotes TGF-β
T13089 16106-16113 Positive_regulation denotes induces
T13090 16106-16113 Positive_regulation denotes induces true
T13091 16106-16113 Positive_regulation denotes induces
T13092 16119-16122 Protein denotes Id2
T13093 16127-16130 Protein denotes Id3
T13094 16131-16141 Gene_expression denotes expression
T13095 16131-16141 Gene_expression denotes expression
T13096 16159-16162 Protein denotes Id1
T13097 16243-16248 Protein denotes TGF-β
T13098 16290-16293 Protein denotes Id2
T13099 16298-16301 Protein denotes Id3
T13100 16346-16355 Gene_expression denotes expressed true
T13101 16346-16355 Gene_expression denotes expressed true
T13102 16409-16412 Protein denotes Id2
T13103 16417-16420 Protein denotes Id3
T13104 16458-16467 Gene_expression denotes expressed
T13105 16458-16467 Gene_expression denotes expressed
T13106 16458-16467 Gene_expression denotes expressed
T13107 16473-16476 Protein denotes Id1
T13108 16506-16511 Protein denotes BMP-6
T13109 16520-16526 Positive_regulation denotes induce true
T13110 16520-16526 Positive_regulation denotes induce true
T13111 16539-16546 Regulation denotes changes
T13112 16539-16546 Regulation denotes changes
T13113 16562-16572 Gene_expression denotes expression
T13114 16562-16572 Gene_expression denotes expression
T13115 16576-16579 Protein denotes Id2
T13116 16584-16587 Protein denotes Id3
T13117 16737-16747 Negative_regulation denotes inhibitors
T13118 16766-16770 Protein denotes Pax5
T13119 16783-16797 Binding denotes forming dimers
T13120 16819-16825 Positive_regulation denotes making
T13121 16841-16845 Binding denotes bind true
T13122 16907-16911 Protein denotes Pax5
T13123 17201-17206 Protein denotes BMP-6
T13124 17235-17247 Positive_regulation denotes upregulation
T13125 17251-17254 Protein denotes Id1
T13126 17408-17413 Protein denotes TGF-β
T13127 17679-17682 Protein denotes Id1
T13128 17727-17740 Positive_regulation denotes overexpressed true
T13129 17850-17855 Protein denotes BMP-6
T13130 18001-18005 Positive_regulation denotes High
T13131 18006-18011 Protein denotes BMP-6
T13132 18012-18027 Transcription denotes mRNA expression
T13133 18144-18154 Gene_expression denotes expression
T13134 18158-18161 Protein denotes Id1
T13135 18302-18307 Protein denotes BMP-6
T13136 18383-18391 Positive_regulation denotes elevated
T13137 18383-18391 Positive_regulation denotes elevated
T13138 18392-18398 Gene_expression denotes levels
T13139 18392-18398 Gene_expression denotes levels
T13140 18402-18405 Protein denotes Id1
T13141 18410-18413 Protein denotes Id3
T13142 18691-18695 Protein denotes Id-1
T13143 18726-18730 Positive_regulation denotes over
T13144 18731-18741 Gene_expression denotes expression
T13145 18745-18755 Negative_regulation denotes inhibition
T13146 18759-18763 Protein denotes Id-1
T13147 18769-18779 Gene_expression denotes expression
T13148 18799-18804 Protein denotes BMP-6
T13149 18866-18871 Protein denotes BMP-6
T13150 18872-18881 Gene_expression denotes producing
T13151 19022-19026 Positive_regulation denotes High
T13152 19027-19032 Protein denotes BMP-6
T13153 19033-19048 Transcription denotes mRNA expression
T13154 19124-19134 Transcription denotes production
T13155 19138-19143 Protein denotes BMP-6
T13156 19228-19237 Regulation denotes autocrine
T13157 19238-19243 Protein denotes BMP-6
T13158 19379-19388 Regulation denotes autocrine true
T13159 19389-19394 Protein denotes BMP-6
T13160 19434-19444 Transcription denotes expression true
T13161 19445-19450 Protein denotes BMP-6
T13162 19522-19534 Positive_regulation denotes upregulation
T13163 19549-19554 Protein denotes BMP-6
T13164 19674-19679 Protein denotes BMP-6
T13165 19846-19853 Transcription denotes express
T13166 19854-19859 Protein denotes BMP-6
T13167 19965-19973 Gene_expression denotes detected true
T13168 19974-19979 Protein denotes BMP-6
T13169 20055-20060 Protein denotes BMP-6
T13170 20061-20071 Gene_expression denotes production true
T13171 20137-20147 Gene_expression denotes production
T13172 20151-20156 Protein denotes BMP-6
T13173 20338-20350 Positive_regulation denotes upregulation
T13174 20358-20363 Protein denotes BMP-6
T13175 20447-20452 Protein denotes TGF-β
T13176 20688-20693 Protein denotes BMP-6
T13177 20844-20849 Protein denotes TGF-β
T13178 20876-20882 Protein denotes TGF-β1
T13179 20887-20892 Protein denotes BMP-4
T13180 21017-21029 Positive_regulation denotes upregulation
T13181 21033-21038 Protein denotes BMP-6
T13182 21082-21088 Transcription denotes detect true
T13183 21089-21094 Protein denotes BMP-6
T13184 21133-21136 Protein denotes CD4
T13185 21141-21144 Protein denotes CD8
T13186 21187-21190 Protein denotes CD3
T13187 21200-21204 Protein denotes CD28
T13188 21315-21320 Protein denotes BMP-6
T13189 21481-21486 Protein denotes BMP-6
T13190 21487-21497 Gene_expression denotes production
T13191 21629-21635 Positive_regulation denotes highly
T13192 21636-21643 Transcription denotes express
T13193 21644-21649 Protein denotes BMP-6
T13194 21707-21714 Gene_expression denotes produce
T13195 21715-21720 Protein denotes BMP-6
T13196 21764-21769 Protein denotes BMP-6
T13197 21812-21817 Protein denotes BMP-6
T13198 21832-21844 Transcription denotes demonstrated true
T13199 22021-22029 Transcription denotes negative true
T13200 22038-22043 Protein denotes BMP-6
T13201 22114-22119 Protein denotes BMP-6
T13202 22120-22130 Gene_expression denotes production true true
T13672 22206-22211 Protein denotes BMP-6
T13673 22293-22304 Positive_regulation denotes consecutive
T13674 22305-22315 Gene_expression denotes production
T13675 22319-22322 Protein denotes Id1
T13676 22360-22365 Protein denotes BMP-6
T13677 22479-22484 Protein denotes CD40L
T13678 22500-22505 Protein denotes BMP-6
T13679 22651-22656 Protein denotes BMP-6
T14121 23147-23151 Protein denotes CD19
T14320 23957-23962 Protein denotes BMP-6
T14321 24006-24013 Protein denotes BMP-RIB
T14322 24014-24019 Protein denotes ALK-6
T14323 24046-24053 Protein denotes BMPR-II
T14324 24098-24104 Protein denotes Noggin
T14325 24311-24322 Protein denotes CD40 ligand
T14326 24324-24329 Protein denotes CD40L
T15041 24499-24506 Protein denotes Act-RIA
T15042 24508-24515 Protein denotes BMP-RIB
T15043 24517-24524 Protein denotes BMPR-II
T15044 24526-24534 Protein denotes Act-RIIA
T15045 24539-24547 Protein denotes Act-RIIb
T15046 24615-24620 Protein denotes BMP-6
T15047 24696-24701 Protein denotes BMP-6
T15048 24758-24763 Protein denotes BMP-6
T15049 24789-24794 Protein denotes BMP-6
T15050 24856-24861 Protein denotes BMP-6
T15051 24987-24992 Protein denotes Smad1
T15052 24994-24996 Protein denotes -5
T15053 25003-25004 Protein denotes 8
T15054 25056-25073 Gene_expression denotes Expression levels true
T15055 25056-25073 Gene_expression denotes Expression levels true
T15056 25077-25080 Protein denotes Id1
T15057 25081-25082 Protein denotes 3
T15058 25156-25163 Negative_regulation denotes blocked
T15059 25156-25163 Negative_regulation denotes blocked
T15060 25427-25434 Protein denotes β-actin
T15061 25512-25516 Protein denotes CD19
T15062 25526-25530 Protein denotes CD19
T15063 25584-25588 Protein denotes CD19
T15064 25641-25645 Protein denotes CD27
T15226 25747-25751 Protein denotes CD19
T15227 25752-25756 Protein denotes CD27
T15228 25761-25765 Protein denotes CD19
T15229 25766-25770 Protein denotes CD27
T15230 25804-25808 Protein denotes CD19
T15231 25826-25830 Protein denotes CD27
T15232 25838-25842 Protein denotes CD19
T15514 26948-26951 Protein denotes Id1
T15515 26953-26956 Protein denotes Id2
T15516 26961-26964 Protein denotes Id3
T15517 27033-27040 Protein denotes β-actin
T16190 27107-27112 Protein denotes BMP-6
T16191 27134-27144 Transcription denotes expression true
T16192 27134-27144 Transcription denotes expression true
T16193 27134-27144 Transcription denotes expression true
T16194 27134-27144 Transcription denotes expression true
T16195 27156-27166 Gene_expression denotes expression true
T16196 27174-27179 Protein denotes BMP-6
T16197 27665-27680 Transcription denotes mRNA expression true
T16198 27665-27680 Transcription denotes mRNA expression true
T16199 27665-27680 Transcription denotes mRNA expression true
T16200 27665-27680 Transcription denotes mRNA expression true
T16201 27684-27688 Protein denotes BMP6
T16202 27690-27693 Protein denotes Id1
T16203 27694-27697 Protein denotes Id4
T16204 27702-27706 Protein denotes PGK1
T16205 27896-27901 Protein denotes BMP-6
T16206 28011-28021 Gene_expression denotes expression true
T16207 28011-28021 Gene_expression denotes expression true
T16208 28070-28074 Protein denotes BMP6
T16209 28107-28110 Protein denotes Id1
T16210 28216-28226 Gene_expression denotes expression true
T16211 28236-28240 Protein denotes PGK1
T16212 28242-28246 Protein denotes PGK1
T16213 28288-28307 Gene_expression denotes have low expression
T16471 28494-28498 Protein denotes CD19
T854 0-5 Protein denotes BMP-6
T855 85-97 Positive_regulation denotes upregulation
T856 101-104 Protein denotes Id1
T857 176-181 Protein denotes TGF-β
T858 293-298 Protein denotes BMP-6
T859 440-445 Protein denotes BMP-6
T860 568-573 Protein denotes BMP-6
T861 582-589 Positive_regulation denotes induced
T862 582-589 Positive_regulation denotes induced
T863 582-589 Positive_regulation denotes induced
T864 590-605 Phosphorylation denotes phosphorylation
T865 590-605 Phosphorylation denotes phosphorylation
T866 590-605 Phosphorylation denotes phosphorylation
T867 609-614 Protein denotes Smad1
T868 615-616 Protein denotes 5
T869 617-618 Protein denotes 8
T870 633-637 Protein denotes Smad
T871 638-653 Phosphorylation denotes phosphorylation
T872 658-666 Positive_regulation denotes followed
T873 658-666 Positive_regulation denotes followed
T874 670-682 Positive_regulation denotes upregulation
T875 670-682 Positive_regulation denotes upregulation
T876 686-689 Protein denotes Id1
T877 699-702 Protein denotes Id1
T878 720-723 Protein denotes Id2
T879 728-731 Protein denotes Id3
T880 732-742 Gene_expression denotes expression
T881 732-742 Gene_expression denotes expression
T882 751-759 Regulation denotes affected true
T883 751-759 Regulation denotes affected true
T884 788-793 Protein denotes BMP-6
R1979 T2472 T2455 themeOf phosphorylation,lead
R1980 T2472 T2456 themeOf phosphorylation,lead
R1981 T2472 T2457 themeOf phosphorylation,lead
R1982 T2472 T2458 themeOf phosphorylation,lead
R1983 T2472 T2459 themeOf phosphorylation,lead
R1984 T2473 T2460 themeOf phosphorylation,lead
R1985 T2473 T2461 themeOf phosphorylation,lead
R5565 T7087 T7088 themeOf BMP-6,production
R5566 T7091 T7090 themeOf BMP-6,produce
R5567 T7093 T7092 themeOf BMP-6,express
R10251 T13029 T13025 themeOf Smad1,phosphorylation
R10252 T13030 T13024 themeOf 5,phosphorylation
R10253 T13031 T13027 themeOf 8,phosphorylation
R10254 T13032 T13033 causeOf BMP-6,induced
R10255 T13092 T13095 themeOf Id2,expression
R10333 T13140 T13138 themeOf Id1,levels
R10334 T13141 T13139 themeOf Id3,levels
R10335 T13144 T13143 themeOf expression,over
R10336 T13146 T13144 themeOf Id-1,expression
R10337 T13146 T13147 themeOf Id-1,expression
R10338 T13147 T13145 themeOf expression,inhibition
R10339 T13149 T13150 themeOf BMP-6,producing
R10341 T13152 T13153 themeOf BMP-6,mRNA expression
R10344 T13153 T13151 themeOf mRNA expression,High
R10345 T13155 T13154 themeOf BMP-6,production
R10346 T13157 T13156 themeOf BMP-6,autocrine
R10351 T13157 T13156 causeOf BMP-6,autocrine
R692 T871 T883 causeOf phosphorylation,affected
R693 T874 T872 themeOf upregulation,followed
R694 T875 T873 themeOf upregulation,followed
R695 T876 T874 themeOf Id1,upregulation
R696 T877 T875 themeOf Id1,upregulation
R697 T878 T880 themeOf Id2,expression
R698 T879 T881 themeOf Id3,expression
R699 T880 T882 themeOf expression,affected
R700 T881 T883 themeOf expression,affected
R1942 T2436 T2437 themeOf BMP-6,increased
R1944 T2438 T2439 themeOf BMP-6,ligation
R1945 T2438 T2440 themeOf BMP-6,heterodimerzation
R1947 T2441 T2442 themeOf BMP-6,ligation
R1948 T2441 T2443 themeOf BMP-6,ligation
R1949 T2441 T2444 themeOf BMP-6,ligation
R1950 T2441 T2445 themeOf BMP-6,ligation
R1951 T2441 T2446 themeOf BMP-6,ligation
R1952 T2441 T2447 themeOf BMP-6,ligation
R1953 T2442 T2454 causeOf ligation,lead
R1954 T2442 T2460 causeOf ligation,lead
R1955 T2442 T2466 causeOf ligation,lead
R1956 T2443 T2455 causeOf ligation,lead
R1957 T2443 T2461 causeOf ligation,lead
R1958 T2443 T2467 causeOf ligation,lead
R1959 T2444 T2456 causeOf ligation,lead
R1960 T2444 T2462 causeOf ligation,lead
R1961 T2444 T2468 causeOf ligation,lead
R1962 T2445 T2457 causeOf ligation,lead
R1963 T2445 T2463 causeOf ligation,lead
R1964 T2445 T2469 causeOf ligation,lead
R1965 T2446 T2458 causeOf ligation,lead
R1966 T2446 T2464 causeOf ligation,lead
R1967 T2446 T2470 causeOf ligation,lead
R1968 T2447 T2459 causeOf ligation,lead
R1969 T2447 T2465 causeOf ligation,lead
R1970 T2447 T2471 causeOf ligation,lead
R1971 T2448 T2442 themeOf Act-RIA,ligation
R1972 T2449 T2443 themeOf BMP-RIA,ligation
R1973 T2450 T2444 themeOf BMP-RIB,ligation
R1974 T2451 T2445 themeOf BMP-RII,ligation
R1975 T2452 T2446 themeOf Act-RIIA,ligation
R1976 T2453 T2447 themeOf Act-RIIB,ligation
R1978 T2472 T2454 themeOf phosphorylation,lead
R1986 T2473 T2462 themeOf phosphorylation,lead
R1987 T2473 T2463 themeOf phosphorylation,lead
R1988 T2473 T2464 themeOf phosphorylation,lead
R1989 T2473 T2465 themeOf phosphorylation,lead
R1990 T2474 T2466 themeOf phosphorylation,lead
R1991 T2474 T2467 themeOf phosphorylation,lead
R1992 T2474 T2468 themeOf phosphorylation,lead
R1993 T2474 T2469 themeOf phosphorylation,lead
R1994 T2474 T2470 themeOf phosphorylation,lead
R1995 T2474 T2471 themeOf phosphorylation,lead
R1996 T2475 T2472 themeOf Smad-1,phosphorylation
R1997 T2475 T2478 themeOf Smad-1,form complexes
R1998 T2475 T2482 themeOf Smad-1,translocated
R2000 T2476 T2473 themeOf Smad-5,phosphorylation
R2001 T2476 T2479 themeOf Smad-5,form complexes
R2002 T2476 T2483 themeOf Smad-5,translocated
R2003 T2477 T2474 themeOf Smad-8,phosphorylation
R2004 T2477 T2480 themeOf Smad-8,form complexes
R2005 T2477 T2484 themeOf Smad-8,translocated
R2010 T2481 T2478 themeOf Smad4,form complexes
R2011 T2481 T2479 themeOf Smad4,form complexes
R2012 T2481 T2480 themeOf Smad4,form complexes
R2015 T2485 T2482 locationOf nucleus,translocated
R2016 T2485 T2483 locationOf nucleus,translocated
R2017 T2485 T2484 locationOf nucleus,translocated
R2021 T2488 T2490 causeOf expression,induced
R2022 T2488 T2491 causeOf expression,induced
R2023 T2489 T2488 themeOf BMP-6,expression
R2024 T2492 T2490 themeOf regulation,induced
R2026 T2493 T2491 themeOf regulation,induced
R2027 T2494 T2492 themeOf Id1,regulation
R2028 T2495 T2493 themeOf Id4,regulation
R2031 T2497 T2496 themeOf BMP-6,producing
R3468 T4472 T4479 themeOf Act-RIA,expressed
R3469 T4473 T4478 themeOf BMP-RIB,expressed
R3470 T4474 T4477 themeOf BMP-RII,expressed
R3471 T4475 T4476 themeOf Act-RIIb,expressed
R3472 T4483 T4481 themeOf Act-RIA,expressed
R3473 T4484 T4482 themeOf BMP-RIB,expressed
R3474 T4485 T4480 themeOf BMP-RII,expressed
R3475 T4488 T4487 themeOf Act-RIA,expressed
R3476 T4489 T4486 themeOf BMP-RII,expressed
R3477 T4491 T4490 themeOf BMP-6,bind
R4073 T5222 T5225 causeOf BMP-6,induces
R4074 T5222 T5223 causeOf BMP-6,induces
R4075 T5222 T5224 causeOf BMP-6,induces
R4076 T5226 T5223 themeOf phosphorylation,induces
R4077 T5227 T5224 themeOf phosphorylation,induces
R4078 T5228 T5225 themeOf phosphorylation,induces
R4079 T5229 T5226 themeOf Smad1,phosphorylation
R4080 T5230 T5227 themeOf 5,phosphorylation
R4081 T5231 T5228 themeOf 8,phosphorylation
R4082 T5237 T5236 themeOf Smad1,phosphorylated
R4083 T5237 T5246 themeOf Smad1,phosphorylation
R4084 T5237 T5253 themeOf Smad1,phosphorylation
R4085 T5238 T5235 themeOf 5,phosphorylated
R4086 T5238 T5245 themeOf 5,phosphorylation
R4087 T5238 T5251 themeOf 5,phosphorylation
R4088 T5239 T5234 themeOf 8,phosphorylated
R4089 T5239 T5244 themeOf 8,phosphorylation
R4090 T5239 T5252 themeOf 8,phosphorylation
R4091 T5240 T5243 causeOf BMP-6,induced
R4092 T5240 T5241 causeOf BMP-6,induced
R4093 T5240 T5242 causeOf BMP-6,induced
R4094 T5244 T5242 themeOf phosphorylation,induced
R4095 T5245 T5241 themeOf phosphorylation,induced
R4096 T5246 T5243 themeOf phosphorylation,induced
R4097 T5247 T5250 causeOf BMP-6,induced
R4098 T5247 T5249 causeOf BMP-6,induced
R4099 T5247 T5248 causeOf BMP-6,induced
R4100 T5251 T5249 themeOf phosphorylation,induced
R4101 T5252 T5248 themeOf phosphorylation,induced
R4102 T5253 T5250 themeOf phosphorylation,induced
R4103 T5258 T5257 themeOf phospho,changes
R4104 T5259 T5258 themeOf STAT3,phospho
R4105 T5260 T5256 themeOf phospho,changes
R4106 T5261 T5260 themeOf p38,phospho
R4107 T5262 T5257 causeOf BMP-6,changes
R4108 T5262 T5256 causeOf BMP-6,changes
R4997 T6327 T6328 causeOf BMP-6,induces
R4998 T6329 T6328 themeOf upregulation,induces
R4999 T6330 T6329 themeOf Id1,upregulation
R5000 T6331 T6333 causeOf BMP-6,induced
R5001 T6331 T6332 causeOf BMP-6,induced
R5002 T6331 T6334 causeOf BMP-6,induced
R5003 T6335 T6334 themeOf phosphorylation,induced
R5004 T6336 T6332 themeOf phosphorylation,induced
R5005 T6337 T6333 themeOf phosphorylation,induced
R5006 T6338 T6336 themeOf Smad 1,phosphorylation
R5007 T6339 T6335 themeOf 5,phosphorylation
R5008 T6340 T6337 themeOf 8,phosphorylation
R5009 T6345 T6344 themeOf Id1,upregulation
R5010 T6346 T6344 causeOf BMP-6,upregulation
R5011 T6348 T6347 themeOf Id1,up-regulation
R5012 T6348 T6349 themeOf Id1,upregulation
R5013 T6350 T6347 causeOf BMP-6,up-regulation
R5014 T6350 T6349 causeOf BMP-6,upregulation
R5015 T6350 T6351 causeOf BMP-6,changes
R5016 T6350 T6352 causeOf BMP-6,changes
R5017 T6350 T6356 causeOf BMP-6,detectable
R5018 T6353 T6351 themeOf Id2,changes
R5019 T6354 T6352 themeOf Id3,changes
R5020 T6355 T6356 themeOf Id4,detectable
R5021 T6357 T6358 causeOf BMP-6,induced
R5022 T6359 T6358 themeOf upregulation,induced
R5023 T6359 T6361 causeOf upregulation,correlated
R5024 T6360 T6359 themeOf Id1,upregulation
R5025 T6362 T6361 themeOf upregulation,correlated
R5026 T6363 T6362 themeOf Id1,upregulation
R5027 T6365 T6364 themeOf Id1,increase
R5028 T6365 T6366 themeOf Id1,increased
R5029 T6365 T6368 themeOf Id1,upregulation
R5030 T6367 T6364 causeOf BMP-6,increase
R5031 T6367 T6366 causeOf BMP-6,increased
R5032 T6367 T6368 causeOf BMP-6,upregulation
R5033 T6367 T6369 causeOf BMP-6,change
R5034 T6367 T6370 causeOf BMP-6,change
R5035 T6371 T6370 themeOf amounts,change
R5036 T6372 T6369 themeOf amounts,change
R5037 T6373 T6372 themeOf Id2,amounts
R5038 T6374 T6371 themeOf Id3,amounts
R5039 T6376 T6375 themeOf Id1,block
R5568 T7096 T7095 themeOf BMP-6,up-regulation
R5569 T7096 T7097 themeOf BMP-6,upregulation
R5570 T7098 T7099 themeOf BMP-6,back to baseline
R5571 T7101 T7100 themeOf upregulation,induced
R5572 T7102 T7101 themeOf BMP-6,upregulation
R5573 T7104 T7103 themeOf BMP-6,express
R5574 T7108 T7107 themeOf BMP-6,recognize
R10188 T12966 T12968 causeOf BMP-6,induced
R10189 T12966 T12967 causeOf BMP-6,induced
R10190 T12966 T12969 causeOf BMP-6,induced
R10192 T12970 T12969 themeOf increase,induced
R10193 T12971 T12967 themeOf increase,induced
R10195 T12972 T12968 themeOf increase,induced
R10196 T12973 T12976 themeOf Smad-1,phosphorylation
R10197 T12974 T12978 themeOf 5,phosphorylation
R10198 T12975 T12977 themeOf 8,phosphorylation
R10199 T12976 T12972 themeOf phosphorylation,increase
R10201 T12977 T12970 themeOf phosphorylation,increase
R10202 T12978 T12971 themeOf phosphorylation,increase
R10203 T12979 T12980 causeOf BMP-6,induced
R10204 T13060 T13053 causeOf phosphorylation,Upregulation
R10205 T12981 T12982 themeOf Smad,phosphorylation
R10206 T12982 T12980 themeOf phosphorylation,induced
R10207 T12982 T12983 causeOf phosphorylation,followed
R10208 T12982 T12984 causeOf phosphorylation,followed
R10209 T12985 T12983 themeOf upregulation,followed
R10210 T12986 T12984 themeOf upregulation,followed
R10211 T12987 T12985 themeOf Id1,upregulation
R10212 T13061 T13054 causeOf phosphorylation,Upregulation
R10213 T12988 T12986 themeOf Id1,upregulation
R10214 T13065 T13062 causeOf BMP-6,mechanism
R10215 T12992 T12994 causeOf Noggin,antagonist
R10216 T12993 T12994 themeOf BMP-6,antagonist
R10217 T13065 T13063 causeOf BMP-6,mechanism
R10218 T13065 T13064 causeOf BMP-6,mechanism
R10219 T13067 T13066 themeOf Id1,upregulation
R10220 T13068 T13066 causeOf BMP-6,upregulation
R10221 T13068 T13073 causeOf BMP-6,remained unchanged
R10222 T13068 T13074 causeOf BMP-6,remained unchanged
R10223 T13069 T13074 themeOf amount,remained unchanged
R10224 T13009 T13007 themeOf Act-RIA,express
R10225 T13009 T13016 themeOf Act-RIA,binding
R10226 T13070 T13073 themeOf amount,remained unchanged
R10227 T13010 T13005 themeOf BMP-RIB,express
R10228 T13071 T13070 themeOf Id2,amount
R10229 T13072 T13069 themeOf Id4,amount
R10230 T13010 T13014 themeOf BMP-RIB,binding
R10231 T13076 T13075 themeOf Id1,upregulation
R10232 T13011 T13006 themeOf BMP-RII,express
R10233 T13011 T13015 themeOf BMP-RII,binding
R10234 T13012 T13008 themeOf Act-RIIb,express
R10235 T13012 T13013 themeOf Act-RIIb,binding
R10236 T13077 T13082 themeOf amount,remained unchanged
R10237 T13017 T13016 themeOf BMP-6,binding
R10238 T13017 T13014 themeOf BMP-6,binding
R10239 T13017 T13015 themeOf BMP-6,binding
R10240 T13017 T13013 themeOf BMP-6,binding
R10241 T13019 T13020 causeOf BMP-2,induce
R10242 T13078 T13081 themeOf amount,remained unchanged
R10243 T13021 T13020 themeOf activation,induce
R10244 T13022 T13021 themeOf STAT3,activation
R10245 T13079 T13078 themeOf Id2,amount
R10246 T13080 T13077 themeOf Id3,amount
R10247 T13083 T13084 themeOf Id1,expressed
R10248 T13028 T13026 themeOf STAT3,phosphorylation
R10249 T13083 T13085 themeOf Id1,expression
R10250 T13087 T13086 themeOf Id1,upregulation
R10256 T13034 T13033 themeOf changes,induced
R10257 T13035 T13034 themeOf phosphorylation,changes
R10258 T13036 T13035 themeOf STAT3,phosphorylation
R10259 T13093 T13094 themeOf Id3,expression
R10260 T13040 T13038 themeOf Smad1,phosphorylation
R10261 T13041 T13039 themeOf 5,phosphorylation
R10262 T13042 T13037 themeOf 8,phosphorylation
R10263 T13094 T13091 themeOf expression,induces
R10264 T13095 T13089 themeOf expression,induces
R10265 T13046 T13044 themeOf phosphorylation,induced
R10266 T13047 T13045 themeOf phosphorylation,induced
R10267 T13096 T13090 themeOf Id1,induces
R10268 T13048 T13043 themeOf phosphorylation,induced
R10269 T13049 T13046 themeOf Smad1,phosphorylation
R10270 T13050 T13047 themeOf 5,phosphorylation
R10271 T13098 T13101 themeOf Id2,expressed
R10272 T13051 T13048 themeOf 8,phosphorylation
R10273 T13052 T13063 themeOf Upregulation,mechanism
R10274 T13053 T13064 themeOf Upregulation,mechanism
R10275 T13099 T13100 themeOf Id3,expressed
R10276 T13054 T13062 themeOf Upregulation,mechanism
R10277 T13055 T13054 themeOf Id1,Upregulation
R10278 T13055 T13052 themeOf Id1,Upregulation
R10279 T13055 T13053 themeOf Id1,Upregulation
R10280 T13056 T13061 themeOf Smad1,phosphorylation
R10281 T13057 T13059 themeOf 5,phosphorylation
R10282 T13058 T13060 themeOf 8,phosphorylation
R10283 T13059 T13052 causeOf phosphorylation,Upregulation
R10284 T13102 T13106 themeOf Id2,expressed
R10285 T13103 T13104 themeOf Id3,expressed
R10286 T13107 T13105 themeOf Id1,expressed
R10287 T13159 T13158 themeOf BMP-6,autocrine
R10288 T13159 T13158 causeOf BMP-6,autocrine
R10289 T13161 T13160 themeOf BMP-6,expression
R10290 T13108 T13109 causeOf BMP-6,induce
R10291 T13163 T13162 themeOf BMP-6,upregulation
R10292 T13108 T13110 causeOf BMP-6,induce
R10293 T13111 T13109 themeOf changes,induce
R10294 T13166 T13165 themeOf BMP-6,express
R10295 T13168 T13167 themeOf BMP-6,detected
R10296 T13169 T13170 themeOf BMP-6,production
R10297 T13112 T13110 themeOf changes,induce
R10298 T13172 T13171 themeOf BMP-6,production
R10299 T13113 T13111 themeOf expression,changes
R10300 T13174 T13173 themeOf BMP-6,upregulation
R10301 T13114 T13112 themeOf expression,changes
R10302 T13115 T13113 themeOf Id2,expression
R10303 T13116 T13114 themeOf Id3,expression
R10304 T13181 T13180 themeOf BMP-6,upregulation
R10305 T13183 T13182 themeOf BMP-6,detect
R10306 T13118 T13117 themeOf Pax5,inhibitors
R10307 T13118 T13119 themeOf Pax5,forming dimers
R10308 T13118 T13121 themeOf Pax5,bind
R10309 T13189 T13190 themeOf BMP-6,production
R10310 T13119 T13117 causeOf forming dimers,inhibitors
R10311 T13192 T13191 themeOf express,highly
R10312 T13119 T13120 causeOf forming dimers,making
R10313 T13193 T13192 themeOf BMP-6,express
R10314 T13121 T13120 themeOf bind,making
R10315 T13195 T13194 themeOf BMP-6,produce
R10316 T13197 T13198 themeOf BMP-6,demonstrated
R10317 T13123 T13124 causeOf BMP-6,upregulation
R10318 T13200 T13199 themeOf BMP-6,negative
R10319 T13201 T13202 themeOf BMP-6,production
R10320 T13125 T13124 themeOf Id1,upregulation
R10321 T13127 T13128 themeOf Id1,overexpressed
R10322 T13131 T13132 themeOf BMP-6,mRNA expression
R10323 T13132 T13130 themeOf mRNA expression,High
R10324 T13134 T13133 themeOf Id1,expression
R10325 T13138 T13137 themeOf levels,elevated
R10328 T13139 T13136 themeOf levels,elevated
R10625 T13674 T13673 themeOf production,consecutive
R10626 T13675 T13674 themeOf Id1,production
R11652 T15054 T15058 themeOf Expression levels,blocked
R11653 T15055 T15059 themeOf Expression levels,blocked
R11654 T15056 T15054 themeOf Id1,Expression levels
R11655 T15057 T15055 themeOf 3,Expression levels
R12507 T16196 T16195 themeOf BMP-6,expression
R12508 T16201 T16193 themeOf BMP6,expression
R12509 T16201 T16200 themeOf BMP6,mRNA expression
R12510 T16202 T16194 themeOf Id1,expression
R12511 T16202 T16198 themeOf Id1,mRNA expression
R12512 T16203 T16199 themeOf Id4,mRNA expression
R12513 T16203 T16192 themeOf Id4,expression
R12514 T16204 T16197 themeOf PGK1,mRNA expression
R12515 T16204 T16191 themeOf PGK1,expression
R12516 T16208 T16206 themeOf BMP6,expression
R12517 T16209 T16207 themeOf Id1,expression
R12518 T16211 T16210 themeOf PGK1,expression
R12519 T16212 T16213 themeOf PGK1,have low expression
R600 T894 T893 themeOf BMP-6,upregulate
R601 T895 T897 causeOf BMP-6,induced
R602 T895 T898 causeOf BMP-6,induced
R603 T895 T896 causeOf BMP-6,induced
R604 T899 T898 themeOf phosphorylation,induced
R605 T899 T905 causeOf phosphorylation,followed
R606 T900 T896 themeOf phosphorylation,induced
R607 T900 T907 causeOf phosphorylation,followed
R608 T901 T897 themeOf phosphorylation,induced
R609 T901 T906 causeOf phosphorylation,followed
R610 T902 T901 themeOf Smad1,phosphorylation
R611 T903 T899 themeOf 5,phosphorylation
R612 T904 T900 themeOf 8,phosphorylation
R613 T908 T906 themeOf upregulation,followed
R614 T908 T905 themeOf upregulation,followed
R615 T908 T907 themeOf upregulation,followed
R616 T909 T908 themeOf Id1,upregulation
R678 T856 T855 themeOf Id1,upregulation
R679 T860 T863 causeOf BMP-6,induced
R680 T860 T862 causeOf BMP-6,induced
R681 T860 T861 causeOf BMP-6,induced
R682 T864 T863 themeOf phosphorylation,induced
R683 T865 T862 themeOf phosphorylation,induced
R684 T866 T861 themeOf phosphorylation,induced
R685 T867 T864 themeOf Smad1,phosphorylation
R686 T868 T865 themeOf 5,phosphorylation
R687 T869 T866 themeOf 8,phosphorylation
R688 T870 T871 themeOf Smad,phosphorylation
R689 T871 T872 causeOf phosphorylation,followed
R690 T871 T873 causeOf phosphorylation,followed
R691 T871 T882 causeOf phosphorylation,affected

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T752 0-5 Protein denotes BMP-6
T753 47-56 Positive_regulation denotes induction
T754 60-64 Protein denotes Smad
T755 65-80 Phosphorylation denotes phosphorylation
T756 176-193 Protein denotes TGF-β superfamily
T757 293-298 Protein denotes BMP-6
T758 373-392 Protein denotes rheumatoid diseases
T759 440-445 Protein denotes BMP-6
T760 523-530 Gene_expression denotes express
T761 531-563 Protein denotes BMP type I and type II receptors
T762 568-573 Protein denotes BMP-6
T763 582-589 Positive_regulation denotes induced
T764 590-605 Phosphorylation denotes phosphorylation
T765 609-618 Protein denotes Smad1/5/8
T766 633-637 Protein denotes Smad
T767 638-653 Phosphorylation denotes phosphorylation
T768 658-666 Positive_regulation denotes followed
T769 658-666 Positive_regulation denotes followed
T770 670-682 Positive_regulation denotes upregulation
T771 670-682 Positive_regulation denotes upregulation
T772 686-694 Protein denotes Id1 mRNA
T773 699-710 Protein denotes Id1 protein
T774 720-723 Protein denotes Id2
T775 728-731 Protein denotes Id3
T776 732-742 Gene_expression denotes expression
T777 732-742 Gene_expression denotes expression
T778 751-759 Regulation denotes affected
T779 751-759 Regulation denotes affected
T780 751-759 Regulation denotes affected
T781 788-793 Protein denotes BMP-6
T782 841-845 Protein denotes CD19
T783 846-850 Protein denotes CD27
T784 873-877 Protein denotes CD19
T785 878-882 Protein denotes CD27
T786 901-909 Protein denotes anti-IgM
T787 942-950 Protein denotes anti-IgM
T788 955-960 Protein denotes CD40L
T789 1196-1206 Positive_regulation denotes upregulate
T790 1207-1217 Protein denotes BMP-6 mRNA
T791 1240-1248 Protein denotes anti-IgM
T792 1287-1292 Protein denotes BMP-6
T793 1328-1335 Positive_regulation denotes induced
T794 1336-1351 Phosphorylation denotes phosphorylation
T795 1355-1364 Protein denotes Smad1/5/8
T796 1380-1392 Positive_regulation denotes upregulation
T797 1396-1399 Protein denotes Id1
T2219 1635-1640 Protein denotes TGF-β
T2220 1646-1654 Protein denotes activins
T2221 1655-1663 Protein denotes inhibins
T2222 2042-2047 Protein denotes TGF-β
T2223 2436-2441 Protein denotes BMP-6
T2224 2939-2947 Binding denotes ligation
T2225 2939-2947 Binding denotes ligation
T2226 2939-2947 Binding denotes ligation
T2227 2952-2969 Binding denotes heterodimerzation
T2228 2952-2969 Binding denotes heterodimerzation
T2229 2984-3004 Protein denotes [activin-like-kinase
T2230 3006-3009 Protein denotes ALK
T2231 3016-3057 Protein denotes type II serine-threonine kinase receptors
T2232 3114-3129 Phosphorylation denotes phosphorylating
T2233 3130-3143 Protein denotes Smad proteins
T2234 3145-3150 Protein denotes BMP-6
T2235 3174-3182 Binding denotes ligation
T2236 3190-3206 Protein denotes type I receptors
T2237 3245-3270 Protein denotes type II receptors BMP-RII
T2238 3272-3280 Protein denotes Act-RIIA
T2239 3285-3293 Protein denotes Act-RIIB
T2240 3301-3305 Positive_regulation denotes lead
T2241 3301-3305 Positive_regulation denotes lead
T2242 3301-3305 Positive_regulation denotes lead
T2243 3301-3305 Positive_regulation denotes lead
T2244 3313-3328 Phosphorylation denotes phosphorylation
T2245 3313-3328 Phosphorylation denotes phosphorylation
T2246 3313-3328 Phosphorylation denotes phosphorylation
T2247 3313-3328 Phosphorylation denotes phosphorylation
T2248 3345-3350 Protein denotes Smads
T2249 3352-3358 Protein denotes Smad-1
T2250 3360-3366 Protein denotes Smad-5
T2251 3372-3378 Protein denotes Smad-8
T2252 3404-3413 Binding denotes complexes
T2253 3426-3430 Protein denotes Smad
T2254 3432-3437 Protein denotes Smad4
T2255 3469-3476 Entity denotes nucleus
T2256 3545-3550 Protein denotes BMP-6
T2257 3791-3801 Gene_expression denotes expression
T2258 3791-3801 Gene_expression denotes expression
T2259 3805-3818 Protein denotes BMP receptors
T2260 3823-3828 Protein denotes BMP-6
T2261 3829-3836 Positive_regulation denotes induced
T2262 3829-3836 Positive_regulation denotes induced
T2263 3829-3836 Positive_regulation denotes induced
T2264 3829-3836 Positive_regulation denotes induced
T2265 3829-3836 Positive_regulation denotes induced
T2266 3829-3836 Positive_regulation denotes induced
T2267 3837-3847 Positive_regulation denotes activation
T2268 3837-3847 Positive_regulation denotes activation
T2269 3855-3859 Protein denotes Smad
T2270 3895-3905 Regulation denotes regulation
T2271 3895-3905 Regulation denotes regulation
T2272 3926-3929 Protein denotes Id1
T2273 3930-3933 Protein denotes Id4
T2274 4012-4021 Gene_expression denotes producing
T2275 4022-4027 Protein denotes BMP-6
T3444 4039-4044 Protein denotes BMP-6
T3445 4045-4053 Negative_regulation denotes inhibits
T3446 4054-4062 Protein denotes anti-IgM
T3447 4071-4084 Localization denotes proliferation
T3448 4088-4095 Protein denotes human B
T3449 4493-4501 Protein denotes anti-IgM
T3450 4509-4514 Protein denotes CD40L
T3451 4581-4586 Protein denotes BMP-6
T3452 4623-4626 Protein denotes IgM
T3453 4737-4745 Protein denotes anti-IgM
T3454 4750-4755 Protein denotes CD40L
T3455 5117-5138 Protein denotes soluble BMP receptors
T3456 5316-5320 Protein denotes CD19
T3457 5321-5325 Protein denotes CD27
T3458 5340-5344 Protein denotes CD19
T3459 5345-5349 Protein denotes CD27
T3460 5435-5439 Protein denotes CD19
T3461 5519-5524 Protein denotes BMP-6
T3462 5535-5540 Protein denotes BMP-6
T3463 5551-5559 Protein denotes anti-IgM
T3464 5572-5581 Gene_expression denotes synthesis
T3465 5572-5581 Gene_expression denotes synthesis
T3958 6164-6172 Protein denotes anti-IgM
T3959 6184-6188 Protein denotes CD27
T3960 6368-6373 Protein denotes CD19+
T3961 6417-6421 Protein denotes CD27
T4426 6502-6509 Protein denotes Human B
T4427 6516-6523 Gene_expression denotes express
T4428 6524-6539 Protein denotes BMP-6 receptors
T4429 6569-6579 Gene_expression denotes expression
T4430 6593-6606 Protein denotes BMP receptors
T4431 6679-6683 Protein denotes BMPs
T4432 6757-6773 Protein denotes II BMP receptors
T4433 6807-6823 Protein denotes type I receptors
T4434 6849-6874 Protein denotes type II receptors BMP-RII
T4435 6879-6887 Protein denotes Act-RIIb
T4436 6892-6901 Gene_expression denotes expressed
T4437 6892-6901 Gene_expression denotes expressed
T4438 6892-6901 Gene_expression denotes expressed
T4439 6951-6960 Gene_expression denotes expressed
T4440 6951-6960 Gene_expression denotes expressed
T4441 6965-6981 Protein denotes type I receptors
T4442 7014-7038 Protein denotes type II receptor BMP-RII
T4443 7135-7144 Gene_expression denotes expressed
T4444 7135-7144 Gene_expression denotes expressed
T4445 7145-7152 Protein denotes Act-RIA
T4446 7157-7164 Protein denotes BMP-RII
T4447 7240-7247 Gene_expression denotes express
T4448 7257-7270 Protein denotes BMP receptors
T4449 7292-7296 Binding denotes bind
T5112 7310-7315 Protein denotes BMP-6
T5113 7316-7323 Positive_regulation denotes induces
T5114 7324-7339 Phosphorylation denotes phosphorylation
T5115 7343-7352 Protein denotes Smad1/5/8
T5116 7365-7372 Binding denotes binding
T5117 7378-7394 Protein denotes type II receptor
T5118 7395-7414 Phosphorylation denotes transphosphorylates
T5119 7419-7428 Positive_regulation denotes activates
T5120 7433-7448 Protein denotes type I receptor
T5121 7450-7466 Protein denotes Type I receptors
T5122 7516-7522 Regulation denotes effect
T5123 7526-7531 Protein denotes BMP-6
T5124 7535-7539 Protein denotes Smad
T5125 7540-7555 Phosphorylation denotes phosphorylation
T5126 7564-7574 Positive_regulation denotes activation
T5127 7578-7582 Protein denotes Smad
T5128 7811-7825 Phosphorylation denotes phosphorylated
T5129 7835-7844 Protein denotes Smad1/5/8
T5130 7933-7940 Positive_regulation denotes induced
T5131 7941-7956 Phosphorylation denotes phosphorylation
T5132 7960-7964 Protein denotes Smad
T5133 7970-7975 Protein denotes BMP-6
T5134 7976-7983 Positive_regulation denotes induced
T5135 7984-7999 Phosphorylation denotes phosphorylation
T5136 8400-8407 Protein denotes phospho
T5137 8408-8413 Protein denotes STAT3
T5138 8417-8424 Protein denotes phospho
T5139 8425-8428 Protein denotes p38
T6186 8553-8558 Protein denotes BMP-6
T6187 8676-8686 Negative_regulation denotes inhibitors
T6188 8676-8686 Negative_regulation denotes inhibitors
T6189 8690-8710 Protein denotes DNA binding proteins
T6190 8712-8715 Protein denotes Ids
T6191 8773-8777 Protein denotes Smad
T6192 8909-8914 Protein denotes BMP-6
T6193 8986-8998 Protein denotes Id1–Id4 mRNA
T6194 9083-9095 Positive_regulation denotes upregulation
T6195 9099-9107 Protein denotes Id1 mRNA
T6196 9149-9162 Positive_regulation denotes up-regulation
T6197 9166-9174 Protein denotes Id1 mRNA
T6198 9280-9285 Protein denotes BMP-6
T6199 9355-9362 Regulation denotes changes
T6200 9355-9362 Regulation denotes changes
T6201 9381-9384 Protein denotes Id2
T6202 9389-9397 Protein denotes Id3 mRNA
T6203 9432-9442 Gene_expression denotes detectable
T6204 9432-9442 Gene_expression denotes detectable
T6205 9525-9537 Positive_regulation denotes upregulation
T6206 9541-9549 Protein denotes Id1 mRNA
T6207 9575-9587 Positive_regulation denotes upregulation
T6208 9591-9602 Protein denotes Id1 protein
T6209 9616-9624 Positive_regulation denotes increase
T6210 9628-9639 Protein denotes Id1 protein
T6211 9854-9860 Regulation denotes change
T6212 9854-9860 Regulation denotes change
T6213 9879-9882 Protein denotes Id2
T6214 9887-9898 Protein denotes Id3 protein
T6215 9961-9964 Protein denotes Id1
T6216 10061-10064 Protein denotes Id1
T6217 10158-10161 Protein denotes Id2
T6218 10166-10169 Protein denotes Id3
T7031 10238-10243 Protein denotes BMP-6
T7032 10397-10404 Gene_expression denotes produce
T7033 10405-10410 Protein denotes BMP-6
T7034 10593-10614 Protein denotes Endogenous BMP-6 mRNA
T7035 10699-10707 Protein denotes anti-IgM
T7036 10754-10767 Positive_regulation denotes up-regulation
T7037 10771-10781 Protein denotes BMP-6 mRNA
T7038 10903-10911 Protein denotes anti-IgM
T7039 10926-10936 Protein denotes BMP-6 mRNA
T7040 11294-11307 Protein denotes BMP-6 protein
T7041 11439-11448 Binding denotes recognize
T7042 11453-11478 Protein denotes recombinant BMP-6 protein
T12307 11574-11597 Protein denotes BMP superfamily members
T12308 11700-11704 Protein denotes BMPs
T12309 11862-11867 Protein denotes CD19+
T12310 11919-11923 Protein denotes CD27
T12311 12005-12010 Protein denotes BMP-6
T12312 12095-12100 Protein denotes BMP-6
T12313 12101-12108 Positive_regulation denotes induced
T12314 12109-12113 Protein denotes Smad
T12315 12114-12129 Phosphorylation denotes phosphorylation
T12316 12134-12142 Positive_regulation denotes followed
T12317 12158-12170 Positive_regulation denotes upregulation
T12318 12158-12170 Positive_regulation denotes upregulation
T12319 12174-12182 Protein denotes Id1 mRNA
T12320 12198-12209 Protein denotes Id1 protein
T12321 12278-12283 Protein denotes BMP-6
T12322 12287-12295 Protein denotes anti-IgM
T12323 12394-12399 Protein denotes BMP-6
T12324 12467-12473 Protein denotes Noggin
T12325 12517-12523 Protein denotes Noggin
T12326 12608-12618 Protein denotes BMP-RIB-Fc
T12327 12623-12626 Protein denotes BMP
T12328 12627-12630 Protein denotes RII
T12329 12631-12633 Protein denotes Fc
T12330 12700-12705 Protein denotes BMP-6
T12331 12752-12770 Protein denotes TGF family members
T12332 13121-13126 Protein denotes BMP-6
T12333 13259-13269 Protein denotes BMP-family
T12334 13466-13470 Protein denotes BMPs
T12335 13626-13638 Protein denotes BMP receptor
T12336 13639-13649 Gene_expression denotes expression
T12337 13715-13722 Gene_expression denotes express
T12338 13715-13722 Gene_expression denotes express
T12339 13715-13722 Gene_expression denotes express
T12340 13715-13722 Gene_expression denotes express
T12341 13727-13747 Protein denotes BMP type I receptors
T12342 13777-13802 Protein denotes type II-receptors BMP-RII
T12343 13807-13810 Protein denotes Act
T12344 13811-13815 Protein denotes RIIb
T12345 13836-13843 Binding denotes binding
T12346 13836-13843 Binding denotes binding
T12347 14228-14238 Positive_regulation denotes activation
T12348 14242-14247 Protein denotes STAT3
T12349 14279-14294 Phosphorylation denotes phosphorylation
T12350 14279-14294 Phosphorylation denotes phosphorylation
T12351 14298-14299 Protein denotes R
T12352 14300-14304 Protein denotes Smad
T12353 14412-14427 Phosphorylation denotes phosphorylation
T12354 14412-14427 Phosphorylation denotes phosphorylation
T12355 14412-14427 Phosphorylation denotes phosphorylation
T12356 14431-14434 Protein denotes p38
T12357 14436-14441 Protein denotes STAT3
T12358 14446-14455 Protein denotes Smad1/5/8
T12359 14667-14674 Regulation denotes changes
T12360 14667-14674 Regulation denotes changes
T12361 14682-14697 Phosphorylation denotes phosphorylation
T12362 14682-14697 Phosphorylation denotes phosphorylation
T12363 14708-14713 Protein denotes STAT3
T12364 14717-14720 Protein denotes p38
T12365 14778-14793 Phosphorylation denotes phosphorylation
T12366 14797-14806 Protein denotes Smad1/5/8
T12367 14877-14884 Positive_regulation denotes induced
T12368 14885-14900 Phosphorylation denotes phosphorylation
T12369 14904-14913 Protein denotes Smad1/5/8
T12370 15098-15102 Protein denotes BMPs
T12371 15121-15133 Positive_regulation denotes Upregulation
T12372 15137-15140 Protein denotes Id1
T12373 15145-15150 Protein denotes Smad1
T12374 15155-15170 Phosphorylation denotes phosphorylation
T12375 15196-15201 Protein denotes BMP-6
T12376 15247-15257 Regulation denotes regulation
T12377 15261-15272 Protein denotes Id-proteins
T12378 15420-15432 Positive_regulation denotes upregulation
T12379 15437-15440 Protein denotes Id1
T12380 15487-15494 Protein denotes Id2–Id4
T12381 15577-15589 Positive_regulation denotes upregulation
T12382 15593-15604 Protein denotes Id1 protein
T12383 15616-15622 Gene_expression denotes amount
T12384 15616-15622 Gene_expression denotes amount
T12385 15626-15629 Protein denotes Id2
T12386 15634-15645 Protein denotes Id3 protein
T12387 15685-15688 Protein denotes Id1
T12388 15719-15728 Gene_expression denotes expressed
T12389 15806-15816 Gene_expression denotes expression
T12390 15927-15939 Positive_regulation denotes upregulation
T12391 15943-15951 Protein denotes Id1 mRNA
T12392 16061-16066 Protein denotes TGF-β
T12393 16106-16113 Positive_regulation denotes induces
T12394 16106-16113 Positive_regulation denotes induces
T12395 16106-16113 Positive_regulation denotes induces
T12396 16119-16122 Protein denotes Id2
T12397 16127-16130 Protein denotes Id3
T12398 16131-16141 Gene_expression denotes expression
T12399 16131-16141 Gene_expression denotes expression
T12400 16131-16141 Gene_expression denotes expression
T12401 16159-16162 Protein denotes Id1
T12402 16243-16248 Protein denotes TGF-β
T12403 16256-16264 Regulation denotes regulate
T12404 16265-16276 Protein denotes Id proteins
T12405 16290-16293 Protein denotes Id2
T12406 16298-16301 Protein denotes Id3
T12407 16327-16338 Protein denotes Id proteins
T12408 16346-16355 Gene_expression denotes expressed
T12409 16346-16355 Gene_expression denotes expressed
T12410 16346-16355 Gene_expression denotes expressed
T12411 16409-16412 Protein denotes Id2
T12412 16417-16428 Protein denotes Id3 protein
T12413 16458-16467 Gene_expression denotes expressed
T12414 16458-16467 Gene_expression denotes expressed
T12415 16458-16467 Gene_expression denotes expressed
T12416 16473-16476 Protein denotes Id1
T12417 16520-16526 Positive_regulation denotes induce
T12418 16520-16526 Positive_regulation denotes induce
T12419 16562-16572 Gene_expression denotes expression
T12420 16562-16572 Gene_expression denotes expression
T12421 16576-16579 Protein denotes Id2
T12422 16584-16587 Protein denotes Id3
T12423 16609-16620 Protein denotes Id proteins
T12424 16700-16711 Protein denotes Id proteins
T12425 16737-16747 Negative_regulation denotes inhibitors
T12426 16766-16770 Protein denotes Pax5
T12427 16907-16911 Protein denotes Pax5
T12428 16916-16927 Protein denotes Id proteins
T12429 17235-17247 Positive_regulation denotes upregulation
T12430 17251-17262 Protein denotes Id1 protein
T12431 17303-17314 Protein denotes Id proteins
T12432 17433-17444 Protein denotes Id proteins
T12433 17608-17617 Protein denotes Id family
T12434 17622-17635 Gene_expression denotes overexpressed
T12435 17622-17635 Positive_regulation denotes overexpressed
T12436 17679-17682 Protein denotes Id1
T12437 17727-17740 Positive_regulation denotes overexpressed
T12438 18001-18016 Protein denotes High BMP-6 mRNA
T12439 18017-18027 Gene_expression denotes expression
T12440 18144-18154 Gene_expression denotes expression
T12441 18158-18161 Protein denotes Id1
T12442 18302-18307 Protein denotes BMP-6
T12443 18383-18391 Positive_regulation denotes elevated
T12444 18383-18391 Positive_regulation denotes elevated
T12445 18392-18398 Gene_expression denotes levels
T12446 18392-18398 Gene_expression denotes levels
T12447 18402-18405 Protein denotes Id1
T12448 18410-18413 Protein denotes Id3
T12449 18523-18534 Protein denotes Id proteins
T12450 18691-18695 Protein denotes Id-1
T12451 18745-18755 Negative_regulation denotes inhibition
T12452 18759-18768 Protein denotes Id-1 gene
T12453 18769-18779 Gene_expression denotes expression
T12454 18799-18804 Protein denotes BMP-6
T12455 19022-19037 Protein denotes High BMP-6 mRNA
T12456 19038-19048 Gene_expression denotes expression
T12457 19124-19134 Gene_expression denotes production
T12458 19138-19155 Protein denotes BMP-6 transcripts
T12459 19633-19641 Protein denotes anti-IgM
T12460 19846-19853 Gene_expression denotes express
T12461 19854-19864 Protein denotes BMP-6 mRNA
T12462 19965-19973 Gene_expression denotes detected
T12463 19974-19987 Protein denotes BMP-6 protein
T12464 20137-20147 Gene_expression denotes production
T12465 20151-20156 Protein denotes BMP-6
T12466 20272-20276 Protein denotes BMPs
T12467 20338-20350 Positive_regulation denotes upregulation
T12468 20382-20385 Protein denotes IgM
T12469 20844-20864 Protein denotes TGF-β family members
T12470 20876-20882 Protein denotes TGF-β1
T12471 21082-21088 Transcription denotes detect
T12472 21089-21106 Protein denotes BMP-6 transcripts
T12473 21133-21137 Protein denotes CD4+
T12474 21141-21145 Protein denotes CD8+
T12475 21182-21190 Protein denotes anti-CD3
T12476 21195-21204 Protein denotes anti-CD28
T12477 21636-21643 Gene_expression denotes express
T12478 21644-21654 Protein denotes BMP-6 mRNA
T12479 21812-21822 Protein denotes BMP-6 mRNA
T13644 22206-22211 Protein denotes BMP-6
T13645 22212-22219 Positive_regulation denotes induces
T13646 22212-22219 Positive_regulation denotes induces
T13647 22220-22230 Positive_regulation denotes activation
T13648 22248-22252 Protein denotes Smad
T13649 22305-22315 Gene_expression denotes production
T13650 22319-22330 Protein denotes Id1 protein
T13651 22360-22365 Protein denotes BMP-6
T13652 22425-22433 Protein denotes anti-IgM
T13653 22466-22474 Protein denotes anti-IgM
T13654 22479-22484 Protein denotes CD40L
T13655 22651-22656 Protein denotes BMP-6
T14117 23826-23830 Protein denotes HL60
T14118 23832-23840 Protein denotes JCRB0085
T14296 24002-24009 Protein denotes rhu BMP
T14297 24010-24013 Protein denotes RIB
T14298 24014-24019 Protein denotes ALK-6
T14299 24020-24022 Protein denotes Fc
T14300 24046-24053 Protein denotes BMPR-II
T14301 24054-24056 Protein denotes Fc
T14302 24163-24188 Protein denotes Anti-IgM F(ab)2 fragments
T14303 24224-24245 Protein denotes human IgM heavy chain
T14304 24307-24322 Protein denotes rhu CD40 ligand
T14305 24324-24329 Protein denotes CD40L
T14979 24479-24498 Protein denotes human BMP-receptors
T14980 24517-24524 Protein denotes BMPR-II
T14981 24526-24534 Protein denotes Act-RIIA
T14982 24539-24547 Protein denotes Act-RIIb
T14983 24615-24628 Protein denotes BMP-6-protein
T14984 25056-25066 Gene_expression denotes Expression
T14985 25077-25091 Protein denotes Id1–3 proteins
T14986 25156-25163 Negative_regulation denotes blocked
T14987 25318-25321 Protein denotes IgG
T14988 25323-25345 Protein denotes horseradish peroxidase
T14989 25347-25350 Protein denotes HRP
T14990 25422-25434 Protein denotes Anti-β-actin
T14991 25584-25592 Protein denotes CD19 PC5
T14992 25636-25648 Protein denotes anti-CD27 PE
T15204 25747-25751 Protein denotes CD19
T15205 25752-25756 Protein denotes CD27
T15206 25761-25765 Protein denotes CD19
T15207 25766-25770 Protein denotes CD27
T15208 25804-25809 Protein denotes CD19+
T15209 25821-25833 Protein denotes anti-CD27 PE
T15210 25838-25846 Protein denotes CD19 PC5
T15211 25919-25950 Protein denotes FACS DiVa from Becton Dickinson
T16129 27107-27126 Protein denotes BMP-6 messenger RNA
T16130 27134-27144 Gene_expression denotes expression
T16131 27670-27680 Transcription denotes expression
T16132 27670-27680 Transcription denotes expression
T16133 27670-27680 Transcription denotes expression
T16134 27670-27680 Transcription denotes expression
T16135 27684-27688 Protein denotes BMP6
T16136 27690-27693 Protein denotes Id1
T16137 27694-27697 Protein denotes Id4
T16138 27702-27710 Protein denotes PGK1 PCR
T16139 28216-28226 Gene_expression denotes expression
T16140 28236-28240 Protein denotes PGK1
T16141 28242-28246 Protein denotes PGK1
T16468 28494-28499 Protein denotes CD19+
T3962 6422-6425 Protein denotes IgG
T15499 26584-26606 Protein denotes horseradish peroxidase
T15500 26608-26611 Protein denotes HRP
T15501 26684-26686 Protein denotes RT
T15502 26948-26951 Protein denotes Id1
T15503 26953-26956 Protein denotes Id2
T15504 26961-26972 Protein denotes Id3 protein
T15505 27033-27040 Protein denotes β-actin
R544 T767 T769 themeOf phosphorylation,followed
R545 T767 T768 themeOf phosphorylation,followed
R546 T770 T768 causeOf upregulation,followed
R547 T771 T769 causeOf upregulation,followed
R548 T772 T770 themeOf Id1 mRNA,upregulation
R549 T773 T771 themeOf Id1 protein,upregulation
R550 T774 T776 themeOf Id2,expression
R551 T774 T778 themeOf Id2,affected
R552 T775 T777 themeOf Id3,expression
R553 T776 T779 themeOf expression,affected
R554 T777 T780 themeOf expression,affected
R555 T790 T789 themeOf BMP-6 mRNA,upregulate
R556 T792 T793 causeOf BMP-6,induced
R557 T794 T793 themeOf phosphorylation,induced
R558 T795 T794 themeOf Smad1/5/8,phosphorylation
R559 T797 T796 themeOf Id1,upregulation
R2789 T3463 T3465 themeOf anti-IgM,synthesis
R3447 T4428 T4427 themeOf BMP-6 receptors,express
R3448 T4430 T4429 themeOf BMP receptors,expression
R3449 T4433 T4436 themeOf type I receptors,expressed
R3450 T4434 T4437 themeOf type II receptors BMP-RII,expressed
R3451 T4435 T4438 themeOf Act-RIIb,expressed
R3452 T4441 T4439 themeOf type I receptors,expressed
R3453 T4442 T4440 themeOf type II receptor BMP-RII,expressed
R3454 T4445 T4443 themeOf Act-RIA,expressed
R3455 T4446 T4444 themeOf BMP-RII,expressed
R12477 T16136 T16132 themeOf Id1,expression
R12478 T16137 T16133 themeOf Id4,expression
R12479 T16138 T16134 themeOf PGK1 PCR,expression
R12480 T16140 T16139 themeOf PGK1,expression
R536 T752 T753 causeOf BMP-6,induction
R537 T754 T755 themeOf Smad,phosphorylation
R538 T755 T753 themeOf phosphorylation,induction
R539 T761 T760 themeOf BMP type I and type II receptors,express
R540 T762 T763 causeOf BMP-6,induced
R541 T764 T763 themeOf phosphorylation,induced
R542 T765 T764 themeOf Smad1/5/8,phosphorylation
R543 T766 T767 themeOf Smad,phosphorylation
R1733 T2230 T2224 themeOf ALK,ligation
R1735 T2230 T2226 themeOf ALK,ligation
R1736 T2230 T2227 themeOf ALK,heterodimerzation
R1737 T2231 T2225 themeOf type II serine-threonine kinase receptors,ligation
R1738 T2231 T2226 themeOf type II serine-threonine kinase receptors,ligation
R1739 T2231 T2228 themeOf type II serine-threonine kinase receptors,heterodimerzation
R1740 T2233 T2232 themeOf Smad proteins,phosphorylating
R1742 T2234 T2235 themeOf BMP-6,ligation
R1743 T2235 T2242 causeOf ligation,lead
R1744 T2235 T2243 causeOf ligation,lead
R1746 T2235 T2240 causeOf ligation,lead
R1747 T2235 T2241 causeOf ligation,lead
R1750 T2239 T2235 themeOf Act-RIIB,ligation
R1753 T2244 T2240 themeOf phosphorylation,lead
R1754 T2245 T2241 themeOf phosphorylation,lead
R1756 T2246 T2242 themeOf phosphorylation,lead
R1757 T2247 T2243 themeOf phosphorylation,lead
R1758 T2248 T2244 themeOf Smads,phosphorylation
R1760 T2249 T2245 themeOf Smad-1,phosphorylation
R1761 T2250 T2246 themeOf Smad-5,phosphorylation
R1762 T2251 T2247 themeOf Smad-8,phosphorylation
R1764 T2253 T2252 themeOf Smad,complexes
R1767 T2257 T2263 causeOf expression,induced
R1768 T2257 T2264 causeOf expression,induced
R1769 T2258 T2265 causeOf expression,induced
R1770 T2258 T2266 causeOf expression,induced
R1771 T2259 T2257 themeOf BMP receptors,expression
R1773 T2260 T2258 themeOf BMP-6,expression
R1774 T2260 T2261 causeOf BMP-6,induced
R1775 T2260 T2262 causeOf BMP-6,induced
R1778 T2267 T2263 themeOf activation,induced
R1779 T2267 T2265 themeOf activation,induced
R1780 T2267 T2261 themeOf activation,induced
R1781 T2268 T2264 themeOf activation,induced
R1782 T2268 T2266 themeOf activation,induced
R1783 T2268 T2262 themeOf activation,induced
R1786 T2270 T2267 themeOf regulation,activation
R1788 T2271 T2268 themeOf regulation,activation
R1790 T2272 T2270 themeOf Id1,regulation
R1791 T2273 T2271 themeOf Id4,regulation
R1793 T2275 T2274 themeOf BMP-6,producing
R2785 T3444 T3445 causeOf BMP-6,inhibits
R2786 T3446 T3447 themeOf anti-IgM,proliferation
R2787 T3447 T3445 themeOf proliferation,inhibits
R2788 T3462 T3464 themeOf BMP-6,synthesis
R3456 T4448 T4447 themeOf BMP receptors,express
R3457 T4448 T4449 themeOf BMP receptors,bind
R3985 T5112 T5113 causeOf BMP-6,induces
R3986 T5114 T5113 themeOf phosphorylation,induces
R3987 T5115 T5114 themeOf Smad1/5/8,phosphorylation
R3988 T5117 T5116 themeOf type II receptor,binding
R3989 T5117 T5118 themeOf type II receptor,transphosphorylates
R3990 T5117 T5119 causeOf type II receptor,activates
R3991 T5120 T5119 themeOf type I receptor,activates
R3992 T5123 T5122 causeOf BMP-6,effect
R3993 T5124 T5125 themeOf Smad,phosphorylation
R3994 T5125 T5122 themeOf phosphorylation,effect
R3995 T5127 T5126 themeOf Smad,activation
R3996 T5129 T5128 themeOf Smad1/5/8,phosphorylated
R3997 T5131 T5130 themeOf phosphorylation,induced
R3998 T5132 T5131 themeOf Smad,phosphorylation
R3999 T5133 T5135 themeOf BMP-6,phosphorylation
R4000 T5135 T5134 themeOf phosphorylation,induced
R4898 T6189 T6187 themeOf DNA binding proteins,inhibitors
R4899 T6190 T6188 themeOf Ids,inhibitors
R4900 T6195 T6194 themeOf Id1 mRNA,upregulation
R4901 T6197 T6196 themeOf Id1 mRNA,up-regulation
R4902 T6201 T6199 themeOf Id2,changes
R4903 T6201 T6203 themeOf Id2,detectable
R4904 T6202 T6200 themeOf Id3 mRNA,changes
R4905 T6202 T6204 themeOf Id3 mRNA,detectable
R4906 T6206 T6205 themeOf Id1 mRNA,upregulation
R4907 T6208 T6207 themeOf Id1 protein,upregulation
R4908 T6210 T6209 themeOf Id1 protein,increase
R4909 T6213 T6211 themeOf Id2,change
R4910 T6214 T6212 themeOf Id3 protein,change
R5542 T7033 T7032 themeOf BMP-6,produce
R5543 T7037 T7036 themeOf BMP-6 mRNA,up-regulation
R5544 T7042 T7041 themeOf recombinant BMP-6 protein,recognize
R9821 T12335 T12336 themeOf BMP receptor,expression
R9822 T12341 T12337 themeOf BMP type I receptors,express
R9823 T12342 T12338 themeOf type II-receptors BMP-RII,express
R9824 T12343 T12339 themeOf Act,express
R9825 T12343 T12345 themeOf Act,binding
R9826 T12344 T12340 themeOf RIIb,express
R9827 T12344 T12346 themeOf RIIb,binding
R9828 T12348 T12347 themeOf STAT3,activation
R9829 T12351 T12349 themeOf R,phosphorylation
R9830 T12352 T12350 themeOf Smad,phosphorylation
R9831 T12356 T12353 themeOf p38,phosphorylation
R9833 T12357 T12354 themeOf STAT3,phosphorylation
R9834 T12358 T12355 themeOf Smad1/5/8,phosphorylation
R9836 T12361 T12359 themeOf phosphorylation,changes
R9837 T12362 T12360 themeOf phosphorylation,changes
R9838 T12363 T12361 themeOf STAT3,phosphorylation
R9840 T12364 T12362 themeOf p38,phosphorylation
R9842 T12366 T12365 themeOf Smad1/5/8,phosphorylation
R9843 T12368 T12367 themeOf phosphorylation,induced
R9844 T12369 T12368 themeOf Smad1/5/8,phosphorylation
R9846 T12373 T12374 themeOf Smad1,phosphorylation
R9848 T12374 T12371 themeOf phosphorylation,Upregulation
R9849 T12377 T12376 themeOf Id-proteins,regulation
R9850 T12379 T12378 themeOf Id1,upregulation
R9851 T12382 T12381 themeOf Id1 protein,upregulation
R9852 T12385 T12383 themeOf Id2,amount
R9853 T12386 T12384 themeOf Id3 protein,amount
R9854 T12387 T12388 themeOf Id1,expressed
R9855 T12387 T12389 themeOf Id1,expression
R9881 T12445 T12443 themeOf levels,elevated
R9882 T12446 T12444 themeOf levels,elevated
R9883 T12447 T12445 themeOf Id1,levels
R9884 T12448 T12446 themeOf Id3,levels
R9885 T12452 T12453 themeOf Id-1 gene,expression
R9889 T12453 T12451 themeOf expression,inhibition
R9890 T12455 T12456 themeOf High BMP-6 mRNA,expression
R9891 T12458 T12457 themeOf BMP-6 transcripts,production
R9895 T12461 T12460 themeOf BMP-6 mRNA,express
R9900 T12463 T12462 themeOf BMP-6 protein,detected
R9904 T12465 T12464 themeOf BMP-6,production
R9909 T12468 T12467 themeOf IgM,upregulation
R9914 T12472 T12471 themeOf BMP-6 transcripts,detect
R9917 T12478 T12477 themeOf BMP-6 mRNA,express
R10615 T13644 T13645 causeOf BMP-6,induces
R10616 T13644 T13646 causeOf BMP-6,induces
R10617 T13647 T13645 themeOf activation,induces
R10618 T13648 T13647 themeOf Smad,activation
R10619 T13649 T13646 themeOf production,induces
R10620 T13650 T13649 themeOf Id1 protein,production
R11642 T14984 T14986 themeOf Expression,blocked
R11643 T14985 T14984 themeOf Id1–3 proteins,Expression
R12475 T16129 T16130 themeOf BMP-6 messenger RNA,expression
R12476 T16135 T16131 themeOf BMP6,expression
R9785 T12312 T12313 causeOf BMP-6,induced
R9832 T12314 T12315 themeOf Smad,phosphorylation
R9835 T12315 T12316 themeOf phosphorylation,followed
R9839 T12315 T12313 themeOf phosphorylation,induced
R9841 T12319 T12317 themeOf Id1 mRNA,upregulation
R9845 T12320 T12318 themeOf Id1 protein,upregulation
R9847 T12419 T12417 themeOf expression,induce
R9856 T12420 T12418 themeOf expression,induce
R9857 T12391 T12390 themeOf Id1 mRNA,upregulation
R9858 T12421 T12419 themeOf Id2,expression
R9859 T12422 T12420 themeOf Id3,expression
R9860 T12396 T12398 themeOf Id2,expression
R9861 T12397 T12399 themeOf Id3,expression
R9862 T12424 T12425 causeOf Id proteins,inhibitors
R9863 T12398 T12393 themeOf expression,induces
R9864 T12399 T12394 themeOf expression,induces
R9865 T12400 T12395 themeOf expression,induces
R9866 T12401 T12400 themeOf Id1,expression
R9867 T12404 T12403 themeOf Id proteins,regulate
R9868 T12426 T12425 themeOf Pax5,inhibitors
R9869 T12405 T12408 themeOf Id2,expressed
R9870 T12406 T12409 themeOf Id3,expressed
R9871 T12407 T12410 themeOf Id proteins,expressed
R9872 T12430 T12429 themeOf Id1 protein,upregulation
R9873 T12411 T12413 themeOf Id2,expressed
R9874 T12412 T12414 themeOf Id3 protein,expressed
R9875 T12433 T12434 themeOf Id family,overexpressed
R9876 T12416 T12415 themeOf Id1,expressed
R9877 T12434 T12435 themeOf overexpressed,overexpressed
R9878 T12436 T12437 themeOf Id1,overexpressed
R9879 T12438 T12439 themeOf High BMP-6 mRNA,expression
R9880 T12441 T12440 themeOf Id1,expression

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T145 1287-1292 Protein denotes BMP-6
T146 1328-1335 Positive_regulation denotes induced
T147 1328-1335 Positive_regulation denotes induced
T148 1328-1335 Positive_regulation denotes induced
T1074 2738-2747 Positive_regulation denotes increased
T1075 3301-3305 Positive_regulation denotes lead
T1076 3313-3328 Phosphorylation denotes phosphorylation
T1077 3301-3305 Positive_regulation denotes lead
T1078 3301-3305 Positive_regulation denotes lead
T1079 3301-3305 Positive_regulation denotes lead
T1080 3301-3305 Positive_regulation denotes lead
T1081 3301-3305 Positive_regulation denotes lead
T1082 3301-3305 Positive_regulation denotes lead
T1083 3313-3328 Phosphorylation denotes phosphorylation
T1084 3301-3305 Positive_regulation denotes lead
T1085 2939-2947 Binding denotes ligation
T1086 3301-3305 Positive_regulation denotes lead
T1087 3301-3305 Positive_regulation denotes lead
T1088 3301-3305 Positive_regulation denotes lead
T1089 3301-3305 Positive_regulation denotes lead
T1090 3301-3305 Positive_regulation denotes lead
T1091 3313-3328 Phosphorylation denotes phosphorylation
T1092 3301-3305 Positive_regulation denotes lead
T1093 3301-3305 Positive_regulation denotes lead
T1094 3301-3305 Positive_regulation denotes lead
T1095 3301-3305 Positive_regulation denotes lead
T1096 2952-2969 Binding denotes heterodimerzation
T1097 3301-3305 Positive_regulation denotes lead
T1098 3399-3413 Binding denotes form complexes
T1099 3399-3413 Binding denotes form complexes
T1100 3399-3413 Binding denotes form complexes
T1101 3447-3459 Localization denotes translocated
T1102 3447-3459 Localization denotes translocated
T1103 3447-3459 Localization denotes translocated
T1104 3791-3801 Gene_expression denotes expression
T1105 3829-3836 Positive_regulation denotes induced
T1106 3895-3905 Regulation denotes regulation
T1107 3174-3182 Binding denotes ligation
T1108 3829-3836 Positive_regulation denotes induced
T1109 3895-3905 Regulation denotes regulation
T1110 4012-4021 Gene_expression denotes producing true
T1111 3174-3182 Binding denotes ligation
T1112 3174-3182 Binding denotes ligation
T1113 3174-3182 Binding denotes ligation
T1114 3174-3182 Binding denotes ligation
T1115 3174-3182 Binding denotes ligation
T1116 1429-1457 Protein denotes transforming growth factor β
T1117 2577-2579 Protein denotes -4
T1118 2581-2582 Protein denotes 6
T1119 2587-2589 Protein denotes -7
T1120 2718-2723 Protein denotes BMP-6
T1121 2888-2893 Protein denotes BMP-6
T1122 3145-3150 Protein denotes BMP-6
T1123 3207-3214 Protein denotes Act-RIA
T1124 3216-3223 Protein denotes BMP-RIA
T1125 3229-3236 Protein denotes BMP-RIB
T1126 3263-3270 Protein denotes BMP-RII
T1127 1459-1464 Protein denotes TGF-β
T1128 3272-3280 Protein denotes Act-RIIA
T1129 3285-3293 Protein denotes Act-RIIB
T1130 3352-3358 Protein denotes Smad-1
T1131 3360-3366 Protein denotes Smad-5
T1132 3372-3378 Protein denotes Smad-8
T1133 3432-3437 Protein denotes Smad4
T1134 3545-3550 Protein denotes BMP-6
T1135 3702-3707 Protein denotes BMP-6
T1136 3823-3828 Protein denotes BMP-6
T1137 3926-3929 Protein denotes Id1
T1138 3930-3933 Protein denotes Id4
T1139 4022-4027 Protein denotes BMP-6
T1140 2042-2047 Protein denotes TGF-β
T1141 3469-3476 Entity denotes nucleus
T1142 2307-2313 Protein denotes BMP- 2
T1143 2315-2317 Protein denotes -4
T1144 2322-2324 Protein denotes -7
T1145 2436-2441 Protein denotes BMP-6
T1146 2570-2575 Protein denotes BMP-2
T1147 1635-1640 Protein denotes TGF-β
T2625 5535-5540 Protein denotes BMP-6
T4031 6524-6529 Protein denotes BMP-6
T4032 6824-6831 Protein denotes Act-RIA
T4033 6833-6840 Protein denotes BMP-RIB
T4034 6867-6874 Protein denotes BMP-RII
T4035 6879-6887 Protein denotes Act-RIIb
T4036 6892-6901 Gene_expression denotes expressed
T4037 6892-6901 Gene_expression denotes expressed
T4038 6892-6901 Gene_expression denotes expressed
T4039 6892-6901 Gene_expression denotes expressed
T4040 6951-6960 Gene_expression denotes expressed
T4041 6951-6960 Gene_expression denotes expressed
T4042 6951-6960 Gene_expression denotes expressed
T4043 6982-6989 Protein denotes Act-RIA
T4044 6998-7005 Protein denotes BMP-RIB
T4045 7031-7038 Protein denotes BMP-RII
T4046 7135-7144 Gene_expression denotes expressed
T4047 7135-7144 Gene_expression denotes expressed
T4048 7145-7152 Protein denotes Act-RIA
T4049 7157-7164 Protein denotes BMP-RII
T4050 7292-7296 Binding denotes bind
T4051 7297-7302 Protein denotes BMP-6
T4575 7843-7844 Protein denotes 8
T4576 7927-7932 Protein denotes BMP-6
T4577 7933-7940 Positive_regulation denotes induced
T4578 7933-7940 Positive_regulation denotes induced
T4579 7933-7940 Positive_regulation denotes induced
T4580 7941-7956 Phosphorylation denotes phosphorylation
T4581 7941-7956 Phosphorylation denotes phosphorylation
T4582 7941-7956 Phosphorylation denotes phosphorylation
T4583 7970-7975 Protein denotes BMP-6
T4584 7976-7983 Positive_regulation denotes induced
T4585 7976-7983 Positive_regulation denotes induced
T4586 7976-7983 Positive_regulation denotes induced
T4587 7984-7999 Phosphorylation denotes phosphorylation
T4588 7984-7999 Phosphorylation denotes phosphorylation
T4589 7984-7999 Phosphorylation denotes phosphorylation
T4590 8280-8285 Protein denotes BMP-6
T4591 8308-8313 Protein denotes BMP-6
T4592 8376-8383 Regulation denotes changes true
T4593 8376-8383 Regulation denotes changes true
T4594 8400-8407 Phosphorylation denotes phospho
T4595 8408-8413 Protein denotes STAT3
T4596 8417-8424 Phosphorylation denotes phospho
T4597 8425-8428 Protein denotes p38
T4598 8434-8439 Protein denotes BMP-6
T5416 9389-9392 Protein denotes Id3
T5417 9407-9410 Protein denotes Id4
T5418 9432-9442 Positive_regulation denotes detectable true
T5419 9511-9516 Protein denotes BMP-6
T5420 9517-9524 Positive_regulation denotes induced
T5421 9525-9537 Positive_regulation denotes upregulation
T5422 9541-9544 Protein denotes Id1
T5423 9559-9569 Positive_regulation denotes correlated
T5424 9575-9587 Positive_regulation denotes upregulation
T5425 9591-9594 Protein denotes Id1
T5426 9616-9624 Positive_regulation denotes increase
T5427 9628-9631 Protein denotes Id1
T5428 9680-9689 Positive_regulation denotes increased
T5429 9711-9716 Protein denotes BMP-6
T5430 9745-9757 Positive_regulation denotes upregulation
T5431 9854-9860 Regulation denotes change true
T5432 9854-9860 Regulation denotes change true
T5440 10126-10131 Protein denotes BMP-6
T5441 10158-10161 Protein denotes Id2
T5442 10166-10169 Protein denotes Id3
T7578 12057-12058 Protein denotes 5
T7579 12059-12060 Protein denotes 8
T7580 12061-12076 Phosphorylation denotes phosphorylation
T7581 12061-12076 Phosphorylation denotes phosphorylation
T7582 12061-12076 Phosphorylation denotes phosphorylation
T7583 12095-12100 Protein denotes BMP-6
T7584 12101-12108 Positive_regulation denotes induced
T7585 12109-12113 Protein denotes Smad
T7586 12114-12129 Phosphorylation denotes phosphorylation
T7587 12134-12142 Positive_regulation denotes followed
T7588 12134-12142 Positive_regulation denotes followed
T7589 12158-12170 Positive_regulation denotes upregulation
T7590 12158-12170 Positive_regulation denotes upregulation
T7591 12174-12177 Protein denotes Id1
T7592 12198-12201 Protein denotes Id1
T7593 12278-12283 Protein denotes BMP-6
T7594 12394-12399 Protein denotes BMP-6
T7595 12467-12473 Protein denotes Noggin
T7596 12517-12523 Protein denotes Noggin
T7597 12542-12547 Protein denotes BMP-6
T7598 12548-12558 Negative_regulation denotes antagonist
T7599 12608-12615 Protein denotes BMP-RIB
T7600 12623-12630 Protein denotes BMP-RII
T7601 12700-12705 Protein denotes BMP-6
T7602 13121-13126 Protein denotes BMP-6
T7603 13188-13193 Protein denotes BMP-2
T7604 13195-13196 Protein denotes 4
T7605 13198-13199 Protein denotes 6
T7606 13204-13206 Protein denotes -7
T7607 13370-13375 Protein denotes BMP-4
T7608 13566-13571 Protein denotes BMP-6
T7609 13715-13722 Gene_expression denotes express
T7610 13715-13722 Gene_expression denotes express
T7611 13715-13722 Gene_expression denotes express
T7612 13715-13722 Gene_expression denotes express
T7613 13748-13755 Protein denotes Act-RIA
T7614 13760-13767 Protein denotes BMP-RIB
T7615 13795-13802 Protein denotes BMP-RII
T7616 13807-13815 Protein denotes Act-RIIb
T7617 13836-13843 Binding denotes binding
T7618 13836-13843 Binding denotes binding
T7619 13836-13843 Binding denotes binding
T7620 13836-13843 Binding denotes binding
T7621 13871-13876 Protein denotes BMP-6
T7622 13905-13910 Protein denotes BMP-6
T7623 14197-14202 Protein denotes BMP-2
T7624 14221-14227 Positive_regulation denotes induce
T7625 14228-14238 Positive_regulation denotes activation
T7626 14242-14247 Protein denotes STAT3
T7627 14341-14346 Protein denotes BMP-2
T7628 14412-14427 Phosphorylation denotes phosphorylation
T7629 14412-14427 Phosphorylation denotes phosphorylation
T7630 14412-14427 Phosphorylation denotes phosphorylation
T7631 14412-14427 Phosphorylation denotes phosphorylation
T7632 14436-14441 Protein denotes STAT3
T7633 14446-14451 Protein denotes Smad1
T7634 14452-14453 Protein denotes 5
T7635 14454-14455 Protein denotes 8
T7636 14653-14658 Protein denotes BMP-6
T7637 14659-14666 Positive_regulation denotes induced true
T7638 14667-14674 Regulation denotes changes
T7639 14682-14697 Phosphorylation denotes phosphorylation
T7640 14708-14713 Protein denotes STAT3
T7641 14778-14793 Phosphorylation denotes phosphorylation
T7642 14778-14793 Phosphorylation denotes phosphorylation
T7643 14778-14793 Phosphorylation denotes phosphorylation
T7644 14797-14802 Protein denotes Smad1
T7645 14803-14804 Protein denotes 5
T7646 14805-14806 Protein denotes 8
T7647 14877-14884 Positive_regulation denotes induced
T7648 14877-14884 Positive_regulation denotes induced
T7649 14877-14884 Positive_regulation denotes induced
T7650 14885-14900 Phosphorylation denotes phosphorylation
T7651 14885-14900 Phosphorylation denotes phosphorylation
T7652 14885-14900 Phosphorylation denotes phosphorylation
T7653 14904-14909 Protein denotes Smad1
T7654 14910-14911 Protein denotes 5
T7655 14912-14913 Protein denotes 8
T7656 15121-15133 Positive_regulation denotes Upregulation
T7657 15121-15133 Positive_regulation denotes Upregulation
T7658 15121-15133 Positive_regulation denotes Upregulation
T7659 15137-15140 Protein denotes Id1
T7660 15145-15150 Protein denotes Smad1
T7661 15151-15152 Protein denotes 5
T7662 15153-15154 Protein denotes 8
T7663 15155-15170 Phosphorylation denotes phosphorylation
T7664 15155-15170 Phosphorylation denotes phosphorylation
T7665 15155-15170 Phosphorylation denotes phosphorylation
T7666 15182-15191 Regulation denotes mechanism
T7667 15182-15191 Regulation denotes mechanism
T7668 15182-15191 Regulation denotes mechanism
T7669 15196-15201 Protein denotes BMP-6
T7670 15420-15432 Positive_regulation denotes upregulation
T7671 15437-15440 Protein denotes Id1
T7672 15444-15449 Protein denotes BMP-6
T7673 15477-15483 Gene_expression denotes amount
T7674 15477-15483 Gene_expression denotes amount
T7675 15487-15490 Protein denotes Id2
T7676 15491-15494 Protein denotes Id4
T7677 15495-15513 Positive_regulation denotes remained unchanged true
T7678 15495-15513 Positive_regulation denotes remained unchanged true
T7679 15577-15589 Positive_regulation denotes upregulation
T7680 15593-15596 Protein denotes Id1
T7681 15616-15622 Gene_expression denotes amount
T7682 15616-15622 Gene_expression denotes amount
T7683 15626-15629 Protein denotes Id2
T7684 15634-15637 Protein denotes Id3
T7685 15653-15671 Positive_regulation denotes remained unchanged true
T7686 15653-15671 Positive_regulation denotes remained unchanged true
T7687 15685-15688 Protein denotes Id1
T7688 15719-15728 Gene_expression denotes expressed true true
T7689 15806-15816 Gene_expression denotes expression
T7690 15927-15939 Positive_regulation denotes upregulation
T7691 15943-15946 Protein denotes Id1
T7692 16061-16066 Protein denotes TGF-β
T7693 16106-16113 Positive_regulation denotes induces
T7694 16106-16113 Positive_regulation denotes induces true
T7695 16106-16113 Positive_regulation denotes induces
T7696 16119-16122 Protein denotes Id2
T7697 16127-16130 Protein denotes Id3
T7698 16131-16141 Gene_expression denotes expression
T7699 16131-16141 Gene_expression denotes expression
T7700 16159-16162 Protein denotes Id1
T7701 16243-16248 Protein denotes TGF-β
T7702 16290-16293 Protein denotes Id2
T7703 16298-16301 Protein denotes Id3
T7704 16346-16355 Gene_expression denotes expressed true
T7705 16346-16355 Gene_expression denotes expressed true
T7706 16409-16412 Protein denotes Id2
T7707 16417-16420 Protein denotes Id3
T7708 16458-16467 Gene_expression denotes expressed
T7709 16458-16467 Gene_expression denotes expressed
T7710 16458-16467 Gene_expression denotes expressed
T7711 16473-16476 Protein denotes Id1
T7712 16506-16511 Protein denotes BMP-6
T7713 16520-16526 Positive_regulation denotes induce true
T7714 16520-16526 Positive_regulation denotes induce true
T7715 16539-16546 Regulation denotes changes
T7716 16539-16546 Regulation denotes changes
T7717 16562-16572 Gene_expression denotes expression
T7718 16562-16572 Gene_expression denotes expression
T7719 16576-16579 Protein denotes Id2
T7720 16584-16587 Protein denotes Id3
T7721 16737-16747 Negative_regulation denotes inhibitors
T7722 16766-16770 Protein denotes Pax5
T7723 16783-16797 Binding denotes forming dimers
T7724 16819-16825 Positive_regulation denotes making
T7725 16841-16845 Binding denotes bind true
T7726 16907-16911 Protein denotes Pax5
T7727 17201-17206 Protein denotes BMP-6
T7728 17235-17247 Positive_regulation denotes upregulation
T7729 17251-17254 Protein denotes Id1
T7730 17408-17413 Protein denotes TGF-β
T7731 17679-17682 Protein denotes Id1
T7732 17727-17740 Positive_regulation denotes overexpressed true
T7733 17850-17855 Protein denotes BMP-6
T7734 18001-18005 Positive_regulation denotes High
T7735 18006-18011 Protein denotes BMP-6
T7736 18012-18027 Transcription denotes mRNA expression
T7737 18144-18154 Gene_expression denotes expression
T7738 18158-18161 Protein denotes Id1
T7739 18302-18307 Protein denotes BMP-6
T7740 18383-18391 Positive_regulation denotes elevated
T7741 18383-18391 Positive_regulation denotes elevated
T7742 18392-18398 Gene_expression denotes levels
T7743 18392-18398 Gene_expression denotes levels
T7744 18402-18405 Protein denotes Id1
T7745 18410-18413 Protein denotes Id3
T7746 18691-18695 Protein denotes Id-1
T7747 18726-18730 Positive_regulation denotes over
T7748 18731-18741 Gene_expression denotes expression
T7749 18745-18755 Negative_regulation denotes inhibition
T7750 18759-18763 Protein denotes Id-1
T7751 18769-18779 Gene_expression denotes expression
T7763 19389-19394 Protein denotes BMP-6
T7764 19434-19444 Transcription denotes expression true
T7765 19445-19450 Protein denotes BMP-6
T7766 19522-19534 Positive_regulation denotes upregulation
T7767 19549-19554 Protein denotes BMP-6
T7768 19674-19679 Protein denotes BMP-6
T7769 19846-19853 Transcription denotes express
T7770 19854-19859 Protein denotes BMP-6
T7771 19965-19973 Gene_expression denotes detected true
T7772 19974-19979 Protein denotes BMP-6
T7773 20055-20060 Protein denotes BMP-6
T7774 20061-20071 Gene_expression denotes production true
T7775 20137-20147 Gene_expression denotes production
T7776 20151-20156 Protein denotes BMP-6
T7777 20338-20350 Positive_regulation denotes upregulation
T7778 20358-20363 Protein denotes BMP-6
T7779 20447-20452 Protein denotes TGF-β
T7780 20688-20693 Protein denotes BMP-6
T7781 20844-20849 Protein denotes TGF-β
T7782 20876-20882 Protein denotes TGF-β1
T7783 20887-20892 Protein denotes BMP-4
T7784 21017-21029 Positive_regulation denotes upregulation
T7785 21033-21038 Protein denotes BMP-6
T7786 21082-21088 Transcription denotes detect true
T7787 21089-21094 Protein denotes BMP-6
T7788 21133-21136 Protein denotes CD4
T7789 21141-21144 Protein denotes CD8
T7790 21187-21190 Protein denotes CD3
T7791 21200-21204 Protein denotes CD28
T7792 21315-21320 Protein denotes BMP-6
T7793 21481-21486 Protein denotes BMP-6
T7794 21487-21497 Gene_expression denotes production
T7795 21629-21635 Positive_regulation denotes highly
T7796 21636-21643 Transcription denotes express
T7797 21644-21649 Protein denotes BMP-6
T7798 21707-21714 Gene_expression denotes produce
T7799 21715-21720 Protein denotes BMP-6
T7800 21764-21769 Protein denotes BMP-6
T7801 21812-21817 Protein denotes BMP-6
T7802 21832-21844 Transcription denotes demonstrated true
T7803 22021-22029 Transcription denotes negative true
T7804 22038-22043 Protein denotes BMP-6
T7805 22114-22119 Protein denotes BMP-6
T7806 22120-22130 Gene_expression denotes production true true
T14402 25427-25434 Protein denotes β-actin
T14403 25512-25516 Protein denotes CD19
T14404 25526-25530 Protein denotes CD19
T14405 25584-25588 Protein denotes CD19
T14406 25641-25645 Protein denotes CD27
T15584 28216-28226 Gene_expression denotes expression true
T15585 28236-28240 Protein denotes PGK1
T15586 28242-28246 Protein denotes PGK1
T15587 28288-28307 Gene_expression denotes have low expression
T104 0-5 Protein denotes BMP-6
T105 85-97 Positive_regulation denotes upregulation
T106 101-104 Protein denotes Id1
T107 176-181 Protein denotes TGF-β
T108 293-298 Protein denotes BMP-6
T109 440-445 Protein denotes BMP-6
T110 568-573 Protein denotes BMP-6
T111 582-589 Positive_regulation denotes induced
T112 582-589 Positive_regulation denotes induced
T113 582-589 Positive_regulation denotes induced
T114 590-605 Phosphorylation denotes phosphorylation
T115 590-605 Phosphorylation denotes phosphorylation
T116 590-605 Phosphorylation denotes phosphorylation
T117 609-614 Protein denotes Smad1
T118 615-616 Protein denotes 5
T119 617-618 Protein denotes 8
T120 633-637 Protein denotes Smad
T121 638-653 Phosphorylation denotes phosphorylation
T122 658-666 Positive_regulation denotes followed
T123 658-666 Positive_regulation denotes followed
T124 670-682 Positive_regulation denotes upregulation
T125 670-682 Positive_regulation denotes upregulation
T126 686-689 Protein denotes Id1
T127 699-702 Protein denotes Id1
T128 720-723 Protein denotes Id2
T129 728-731 Protein denotes Id3
T130 732-742 Gene_expression denotes expression
T131 732-742 Gene_expression denotes expression
T132 751-759 Regulation denotes affected true
T133 751-759 Regulation denotes affected true
T134 788-793 Protein denotes BMP-6
T135 841-845 Protein denotes CD19
T136 846-850 Protein denotes CD27
T137 873-877 Protein denotes CD19
T138 878-882 Protein denotes CD27
T139 955-960 Protein denotes CD40L
T140 976-981 Protein denotes BMP-6
T141 1075-1080 Protein denotes BMP-6
T142 1146-1152 Protein denotes noggin
T143 1196-1206 Positive_regulation denotes upregulate
T144 1207-1212 Protein denotes BMP-6
T149 1336-1351 Phosphorylation denotes phosphorylation
T150 1336-1351 Phosphorylation denotes phosphorylation
T151 1336-1351 Phosphorylation denotes phosphorylation
T152 1355-1360 Protein denotes Smad1
T153 1361-1362 Protein denotes 5
T154 1363-1364 Protein denotes 8
T155 1365-1373 Positive_regulation denotes followed
T156 1365-1373 Positive_regulation denotes followed
T157 1365-1373 Positive_regulation denotes followed
T158 1380-1392 Positive_regulation denotes upregulation
T159 1396-1399 Protein denotes Id1
T15251 26948-26951 Protein denotes Id1
T15252 26953-26956 Protein denotes Id2
T15253 26961-26964 Protein denotes Id3
T15254 27033-27040 Protein denotes β-actin
T14139 23957-23962 Protein denotes BMP-6
T14140 24006-24013 Protein denotes BMP-RIB
T14141 24014-24019 Protein denotes ALK-6
T14142 24046-24053 Protein denotes BMPR-II
T14143 24098-24104 Protein denotes Noggin
T14144 24311-24322 Protein denotes CD40 ligand
T14145 24324-24329 Protein denotes CD40L
T5389 8480-8485 Protein denotes BMP-6
T5390 8486-8493 Positive_regulation denotes induces
T5391 8494-8506 Positive_regulation denotes upregulation
T5392 8510-8513 Protein denotes Id1
T5393 8553-8558 Protein denotes BMP-6
T5394 8559-8566 Positive_regulation denotes induced
T5395 8559-8566 Positive_regulation denotes induced
T5396 8559-8566 Positive_regulation denotes induced
T5397 8567-8582 Phosphorylation denotes phosphorylation
T5398 8567-8582 Phosphorylation denotes phosphorylation
T5399 8567-8582 Phosphorylation denotes phosphorylation
T5400 8586-8592 Protein denotes Smad 1
T5401 8593-8594 Protein denotes 5
T5402 8595-8596 Protein denotes 8
T5403 8909-8914 Protein denotes BMP-6
T5404 8986-8989 Protein denotes Id1
T5405 8990-8993 Protein denotes Id4
T5406 9083-9095 Positive_regulation denotes upregulation
T5407 9099-9102 Protein denotes Id1
T5408 9111-9116 Protein denotes BMP-6
T5409 9149-9162 Positive_regulation denotes up-regulation
T5410 9166-9169 Protein denotes Id1
T5411 9235-9247 Positive_regulation denotes upregulation
T5412 9280-9285 Protein denotes BMP-6
T5413 9355-9362 Regulation denotes changes true
T5414 9355-9362 Regulation denotes changes true
T5415 9381-9384 Protein denotes Id2
T5433 9868-9875 Gene_expression denotes amounts
T5434 9868-9875 Gene_expression denotes amounts
T5435 9879-9882 Protein denotes Id2
T5436 9887-9890 Protein denotes Id3
T5437 9951-9956 Negative_regulation denotes block
T5438 9961-9964 Protein denotes Id1
T5439 10061-10064 Protein denotes Id1
T4558 7310-7315 Protein denotes BMP-6
T4559 7316-7323 Positive_regulation denotes induces
T4560 7316-7323 Positive_regulation denotes induces
T4561 7316-7323 Positive_regulation denotes induces
T4562 7324-7339 Phosphorylation denotes phosphorylation
T4563 7324-7339 Phosphorylation denotes phosphorylation
T4564 7324-7339 Phosphorylation denotes phosphorylation
T4565 7343-7348 Protein denotes Smad1
T4566 7349-7350 Protein denotes 5
T4567 7351-7352 Protein denotes 8
T4568 7526-7531 Protein denotes BMP-6
T4569 7720-7725 Protein denotes BMP-6
T4570 7811-7825 Phosphorylation denotes phosphorylated true
T4571 7811-7825 Phosphorylation denotes phosphorylated true
T4572 7811-7825 Phosphorylation denotes phosphorylated true
T4573 7835-7840 Protein denotes Smad1
T4574 7841-7842 Protein denotes 5
T15093 25747-25751 Protein denotes CD19
T15094 25752-25756 Protein denotes CD27
T15095 25761-25765 Protein denotes CD19
T15096 25766-25770 Protein denotes CD27
T15097 25804-25808 Protein denotes CD19
T15098 25826-25830 Protein denotes CD27
T15099 25838-25842 Protein denotes CD19
T3570 5772-5777 Protein denotes BMP-6
T3571 5874-5879 Protein denotes BMP-6
T3572 6025-6030 Protein denotes BMP-6
T3573 6060-6065 Protein denotes BMP-6
T3574 6184-6188 Protein denotes CD27
T3575 6318-6323 Protein denotes BMP-6
T3576 6368-6372 Protein denotes CD19
T3577 6417-6421 Protein denotes CD27
T13699 23147-23151 Protein denotes CD19
T13392 22206-22211 Protein denotes BMP-6
T13393 22293-22304 Positive_regulation denotes consecutive
T13394 22305-22315 Gene_expression denotes production
T13395 22319-22322 Protein denotes Id1
T13396 22360-22365 Protein denotes BMP-6
T13397 22479-22484 Protein denotes CD40L
T13398 22500-22505 Protein denotes BMP-6
T13399 22651-22656 Protein denotes BMP-6
T6459 10196-10201 Protein denotes BMP-6
T6460 10202-10212 Gene_expression denotes production
T6461 10238-10243 Protein denotes BMP-6
T6462 10397-10404 Gene_expression denotes produce true
T6463 10405-10410 Protein denotes BMP-6
T6464 10471-10478 Transcription denotes express
T6465 10479-10484 Protein denotes BMP-6
T6466 10604-10609 Protein denotes BMP-6
T6467 10754-10767 Positive_regulation denotes up-regulation
T6468 10771-10776 Protein denotes BMP-6
T6469 10857-10869 Positive_regulation denotes upregulation
T6470 10926-10931 Protein denotes BMP-6
T6471 10941-10957 Negative_regulation denotes back to baseline
T6472 11044-11051 Positive_regulation denotes induced
T6473 11064-11076 Positive_regulation denotes upregulation
T6474 11080-11085 Protein denotes BMP-6
T6475 11186-11193 Transcription denotes express true
T6476 11194-11199 Protein denotes BMP-6
T6477 11294-11299 Protein denotes BMP-6
T6478 11413-11418 Protein denotes BMP-6
T6479 11439-11448 Binding denotes recognize true
T6480 11465-11470 Protein denotes BMP-6
T15564 27107-27112 Protein denotes BMP-6
T15565 27134-27144 Transcription denotes expression true
T15566 27134-27144 Transcription denotes expression true
T15567 27134-27144 Transcription denotes expression true
T15568 27134-27144 Transcription denotes expression true
T15569 27156-27166 Gene_expression denotes expression true
T15570 27174-27179 Protein denotes BMP-6
T15571 27665-27680 Transcription denotes mRNA expression true
T15572 27665-27680 Transcription denotes mRNA expression true
T15573 27665-27680 Transcription denotes mRNA expression true
T15574 27665-27680 Transcription denotes mRNA expression true
T15575 27684-27688 Protein denotes BMP6
T15576 27690-27693 Protein denotes Id1
T15577 27694-27697 Protein denotes Id4
T15578 27702-27706 Protein denotes PGK1
T15579 27896-27901 Protein denotes BMP-6
T15580 28011-28021 Gene_expression denotes expression true
T15581 28011-28021 Gene_expression denotes expression true
T15582 28070-28074 Protein denotes BMP6
T15583 28107-28110 Protein denotes Id1
T2604 4039-4044 Protein denotes BMP-6
T2605 4117-4122 Protein denotes BMP-6
T2606 4210-4215 Protein denotes BMP-6
T2607 4416-4421 Protein denotes BMP-6
T2608 4509-4514 Protein denotes CD40L
T2609 4545-4550 Protein denotes BMP-6
T2610 4581-4586 Protein denotes BMP-6
T2611 4750-4755 Protein denotes CD40L
T2612 4800-4805 Protein denotes BMP-6
T2613 4990-4995 Protein denotes BMP-6
T2614 5065-5071 Protein denotes Noggin
T2615 5139-5146 Protein denotes BMP-RIB
T2616 5154-5161 Protein denotes BMP-RII
T2617 5197-5202 Protein denotes BMP-6
T2618 5253-5258 Protein denotes BMP-6
T2619 5316-5320 Protein denotes CD19
T2620 5321-5325 Protein denotes CD27
T2621 5340-5344 Protein denotes CD19
T2622 5345-5349 Protein denotes CD27
T2623 5435-5439 Protein denotes CD19
T2624 5519-5524 Protein denotes BMP-6
T14383 24499-24506 Protein denotes Act-RIA
T14384 24508-24515 Protein denotes BMP-RIB
T14385 24517-24524 Protein denotes BMPR-II
T14386 24526-24534 Protein denotes Act-RIIA
T14387 24539-24547 Protein denotes Act-RIIb
T14388 24615-24620 Protein denotes BMP-6
T14389 24696-24701 Protein denotes BMP-6
T14390 24758-24763 Protein denotes BMP-6
T14391 24789-24794 Protein denotes BMP-6
T14392 24856-24861 Protein denotes BMP-6
T14393 24987-24992 Protein denotes Smad1
T14394 24994-24996 Protein denotes -5
T14395 25003-25004 Protein denotes 8
T14396 25056-25073 Gene_expression denotes Expression levels true
T14397 25056-25073 Gene_expression denotes Expression levels true
T14398 25077-25080 Protein denotes Id1
T14399 25081-25082 Protein denotes 3
T14400 25156-25163 Negative_regulation denotes blocked
T14401 25156-25163 Negative_regulation denotes blocked
T7566 11836-11841 Protein denotes BMP-6
T7567 11862-11866 Protein denotes CD19
T7568 11891-11896 Protein denotes BMP-6
T7569 11919-11923 Protein denotes CD27
T7570 12005-12010 Protein denotes BMP-6
T7571 12011-12018 Positive_regulation denotes induced
T7572 12011-12018 Positive_regulation denotes induced
T7573 12011-12018 Positive_regulation denotes induced
T7574 12038-12046 Positive_regulation denotes increase
T7575 12038-12046 Positive_regulation denotes increase
T7576 12038-12046 Positive_regulation denotes increase
T7577 12050-12056 Protein denotes Smad-1
T7752 18799-18804 Protein denotes BMP-6
T7753 18866-18871 Protein denotes BMP-6
T7754 18872-18881 Gene_expression denotes producing
T7755 19022-19026 Positive_regulation denotes High
T7756 19027-19032 Protein denotes BMP-6
T7757 19033-19048 Transcription denotes mRNA expression
T7758 19124-19134 Transcription denotes production
T7759 19138-19143 Protein denotes BMP-6
T7760 19228-19237 Regulation denotes autocrine
T7761 19238-19243 Protein denotes BMP-6
T7762 19379-19388 Regulation denotes autocrine true
T16229 28494-28498 Protein denotes CD19
R665 T149 T148 themeOf phosphorylation,induced
R666 T149 T155 causeOf phosphorylation,followed
R667 T150 T146 themeOf phosphorylation,induced
R668 T150 T157 causeOf phosphorylation,followed
R669 T151 T147 themeOf phosphorylation,induced
R670 T151 T156 causeOf phosphorylation,followed
R671 T152 T151 themeOf Smad1,phosphorylation
R672 T153 T149 themeOf 5,phosphorylation
R673 T154 T150 themeOf 8,phosphorylation
R674 T158 T156 themeOf upregulation,followed
R675 T158 T155 themeOf upregulation,followed
R676 T158 T157 themeOf upregulation,followed
R677 T159 T158 themeOf Id1,upregulation
R775 T1076 T1075 themeOf phosphorylation,lead
R776 T1076 T1077 themeOf phosphorylation,lead
R777 T1076 T1078 themeOf phosphorylation,lead
R778 T1076 T1079 themeOf phosphorylation,lead
R779 T1076 T1080 themeOf phosphorylation,lead
R780 T1076 T1081 themeOf phosphorylation,lead
R781 T1083 T1082 themeOf phosphorylation,lead
R794 T1104 T1108 causeOf expression,induced
R795 T1106 T1105 themeOf regulation,induced
R796 T1107 T1075 causeOf ligation,lead
R797 T1107 T1082 causeOf ligation,lead
R798 T1107 T1090 causeOf ligation,lead
R799 T1109 T1108 themeOf regulation,induced
R800 T1111 T1077 causeOf ligation,lead
R801 T1111 T1084 causeOf ligation,lead
R802 T1111 T1092 causeOf ligation,lead
R803 T1112 T1078 causeOf ligation,lead
R804 T1112 T1086 causeOf ligation,lead
R805 T1112 T1093 causeOf ligation,lead
R806 T1113 T1079 causeOf ligation,lead
R807 T1113 T1087 causeOf ligation,lead
R808 T1113 T1094 causeOf ligation,lead
R809 T1114 T1080 causeOf ligation,lead
R810 T1114 T1088 causeOf ligation,lead
R811 T1114 T1095 causeOf ligation,lead
R812 T1115 T1081 causeOf ligation,lead
R813 T1115 T1089 causeOf ligation,lead
R814 T1115 T1097 causeOf ligation,lead
R815 T1120 T1074 themeOf BMP-6,increased
R816 T1121 T1085 themeOf BMP-6,ligation
R817 T1121 T1096 themeOf BMP-6,heterodimerzation
R818 T1122 T1107 themeOf BMP-6,ligation
R819 T1122 T1111 themeOf BMP-6,ligation
R820 T1122 T1112 themeOf BMP-6,ligation
R821 T1122 T1113 themeOf BMP-6,ligation
R822 T1122 T1114 themeOf BMP-6,ligation
R823 T1122 T1115 themeOf BMP-6,ligation
R824 T1123 T1107 themeOf Act-RIA,ligation
R825 T1124 T1111 themeOf BMP-RIA,ligation
R826 T1125 T1112 themeOf BMP-RIB,ligation
R827 T1126 T1113 themeOf BMP-RII,ligation
R828 T1128 T1114 themeOf Act-RIIA,ligation
R829 T1129 T1115 themeOf Act-RIIB,ligation
R830 T1130 T1076 themeOf Smad-1,phosphorylation
R831 T1130 T1098 themeOf Smad-1,form complexes
R832 T1130 T1101 themeOf Smad-1,translocated
R833 T1131 T1083 themeOf Smad-5,phosphorylation
R834 T1131 T1099 themeOf Smad-5,form complexes
R835 T1131 T1102 themeOf Smad-5,translocated
R836 T1132 T1091 themeOf Smad-8,phosphorylation
R837 T1132 T1100 themeOf Smad-8,form complexes
R838 T1132 T1103 themeOf Smad-8,translocated
R839 T1133 T1098 themeOf Smad4,form complexes
R840 T1133 T1099 themeOf Smad4,form complexes
R841 T1133 T1100 themeOf Smad4,form complexes
R842 T1136 T1104 themeOf BMP-6,expression
R843 T1137 T1106 themeOf Id1,regulation
R844 T1138 T1109 themeOf Id4,regulation
R845 T1139 T1110 themeOf BMP-6,producing
R846 T1141 T1101 locationOf nucleus,translocated
R847 T1141 T1102 locationOf nucleus,translocated
R848 T1141 T1103 locationOf nucleus,translocated
R3557 T4596 T4592 themeOf phospho,changes
R3558 T4597 T4596 themeOf p38,phospho
R3559 T4598 T4593 causeOf BMP-6,changes
R3560 T4598 T4592 causeOf BMP-6,changes
R4219 T5412 T5418 causeOf BMP-6,detectable
R4220 T5415 T5413 themeOf Id2,changes
R4221 T5416 T5414 themeOf Id3,changes
R4222 T5417 T5418 themeOf Id4,detectable
R4223 T5419 T5420 causeOf BMP-6,induced
R4224 T5421 T5420 themeOf upregulation,induced
R4225 T5421 T5423 causeOf upregulation,correlated
R4226 T5422 T5421 themeOf Id1,upregulation
R4227 T5424 T5423 themeOf upregulation,correlated
R4228 T5425 T5424 themeOf Id1,upregulation
R4229 T5427 T5426 themeOf Id1,increase
R4230 T5427 T5428 themeOf Id1,increased
R4231 T5427 T5430 themeOf Id1,upregulation
R4232 T5429 T5426 causeOf BMP-6,increase
R4233 T5429 T5428 causeOf BMP-6,increased
R4234 T5429 T5430 causeOf BMP-6,upregulation
R4235 T5429 T5431 causeOf BMP-6,change
R4236 T5429 T5432 causeOf BMP-6,change
R4237 T5433 T5432 themeOf amounts,change
R4238 T5434 T5431 themeOf amounts,change
R4239 T5435 T5434 themeOf Id2,amounts
R4240 T5436 T5433 themeOf Id3,amounts
R4241 T5438 T5437 themeOf Id1,block
R5822 T7570 T7572 causeOf BMP-6,induced
R5823 T7570 T7571 causeOf BMP-6,induced
R5824 T7570 T7573 causeOf BMP-6,induced
R5825 T7574 T7573 themeOf increase,induced
R5826 T7575 T7571 themeOf increase,induced
R5827 T7576 T7572 themeOf increase,induced
R5828 T7577 T7580 themeOf Smad-1,phosphorylation
R5829 T7578 T7582 themeOf 5,phosphorylation
R5830 T7579 T7581 themeOf 8,phosphorylation
R5831 T7580 T7576 themeOf phosphorylation,increase
R5832 T7581 T7574 themeOf phosphorylation,increase
R5833 T7582 T7575 themeOf phosphorylation,increase
R5834 T7583 T7584 causeOf BMP-6,induced
R5835 T7585 T7586 themeOf Smad,phosphorylation
R5836 T7586 T7584 themeOf phosphorylation,induced
R5837 T7586 T7587 causeOf phosphorylation,followed
R5838 T7586 T7588 causeOf phosphorylation,followed
R5839 T7589 T7587 themeOf upregulation,followed
R5840 T7590 T7588 themeOf upregulation,followed
R5841 T7591 T7589 themeOf Id1,upregulation
R5842 T7592 T7590 themeOf Id1,upregulation
R5843 T7596 T7598 causeOf Noggin,antagonist
R5844 T7597 T7598 themeOf BMP-6,antagonist
R5845 T7613 T7611 themeOf Act-RIA,express
R5846 T7613 T7620 themeOf Act-RIA,binding
R5847 T7614 T7609 themeOf BMP-RIB,express
R5848 T7614 T7618 themeOf BMP-RIB,binding
R5849 T7615 T7610 themeOf BMP-RII,express
R5850 T7615 T7619 themeOf BMP-RII,binding
R5851 T7616 T7612 themeOf Act-RIIb,express
R5852 T7616 T7617 themeOf Act-RIIb,binding
R5853 T7621 T7620 themeOf BMP-6,binding
R5854 T7621 T7618 themeOf BMP-6,binding
R5855 T7621 T7619 themeOf BMP-6,binding
R5856 T7621 T7617 themeOf BMP-6,binding
R5857 T7623 T7624 causeOf BMP-2,induce
R5858 T7625 T7624 themeOf activation,induce
R5859 T7626 T7625 themeOf STAT3,activation
R5860 T7632 T7630 themeOf STAT3,phosphorylation
R5861 T7633 T7629 themeOf Smad1,phosphorylation
R5862 T7634 T7628 themeOf 5,phosphorylation
R5863 T7635 T7631 themeOf 8,phosphorylation
R5864 T7636 T7637 causeOf BMP-6,induced
R5865 T7638 T7637 themeOf changes,induced
R5866 T7639 T7638 themeOf phosphorylation,changes
R5867 T7640 T7639 themeOf STAT3,phosphorylation
R5868 T7644 T7642 themeOf Smad1,phosphorylation
R5869 T7645 T7643 themeOf 5,phosphorylation
R5870 T7646 T7641 themeOf 8,phosphorylation
R5871 T7650 T7648 themeOf phosphorylation,induced
R5872 T7651 T7649 themeOf phosphorylation,induced
R5873 T7652 T7647 themeOf phosphorylation,induced
R5874 T7653 T7650 themeOf Smad1,phosphorylation
R5875 T7654 T7651 themeOf 5,phosphorylation
R5876 T7655 T7652 themeOf 8,phosphorylation
R5880 T7659 T7658 themeOf Id1,Upregulation
R5886 T7663 T7656 causeOf phosphorylation,Upregulation
R5887 T7664 T7657 causeOf phosphorylation,Upregulation
R5888 T7665 T7658 causeOf phosphorylation,Upregulation
R5889 T7669 T7666 causeOf BMP-6,mechanism
R5890 T7669 T7667 causeOf BMP-6,mechanism
R5891 T7669 T7668 causeOf BMP-6,mechanism
R5892 T7671 T7670 themeOf Id1,upregulation
R5893 T7672 T7670 causeOf BMP-6,upregulation
R5894 T7672 T7677 causeOf BMP-6,remained unchanged
R5895 T7672 T7678 causeOf BMP-6,remained unchanged
R5896 T7673 T7678 themeOf amount,remained unchanged
R5897 T7674 T7677 themeOf amount,remained unchanged
R5898 T7675 T7674 themeOf Id2,amount
R5899 T7676 T7673 themeOf Id4,amount
R5900 T7680 T7679 themeOf Id1,upregulation
R5901 T7681 T7686 themeOf amount,remained unchanged
R5902 T7682 T7685 themeOf amount,remained unchanged
R5903 T7683 T7682 themeOf Id2,amount
R5904 T7684 T7681 themeOf Id3,amount
R5905 T7687 T7688 themeOf Id1,expressed
R5906 T7687 T7689 themeOf Id1,expression
R5938 T7742 T7741 themeOf levels,elevated
R5939 T7743 T7740 themeOf levels,elevated
R5940 T7744 T7742 themeOf Id1,levels
R5941 T7745 T7743 themeOf Id3,levels
R5942 T7748 T7747 themeOf expression,over
R5943 T7750 T7748 themeOf Id-1,expression
R5944 T7750 T7751 themeOf Id-1,expression
R5945 T7751 T7749 themeOf expression,inhibition
R5946 T7753 T7754 themeOf BMP-6,producing
R5947 T7756 T7757 themeOf BMP-6,mRNA expression
R5948 T7757 T7755 themeOf mRNA expression,High
R5949 T7759 T7758 themeOf BMP-6,production
R5950 T7761 T7760 themeOf BMP-6,autocrine
R5951 T7761 T7760 causeOf BMP-6,autocrine
R5952 T7763 T7762 themeOf BMP-6,autocrine
R5953 T7763 T7762 causeOf BMP-6,autocrine
R5954 T7765 T7764 themeOf BMP-6,expression
R5955 T7767 T7766 themeOf BMP-6,upregulation
R5956 T7770 T7769 themeOf BMP-6,express
R5957 T7772 T7771 themeOf BMP-6,detected
R5958 T7773 T7774 themeOf BMP-6,production
R5959 T7776 T7775 themeOf BMP-6,production
R5960 T7778 T7777 themeOf BMP-6,upregulation
R5961 T7785 T7784 themeOf BMP-6,upregulation
R5962 T7787 T7786 themeOf BMP-6,detect
R5963 T7793 T7794 themeOf BMP-6,production
R5964 T7796 T7795 themeOf express,highly
R5965 T7797 T7796 themeOf BMP-6,express
R5966 T7799 T7798 themeOf BMP-6,produce
R5967 T7801 T7802 themeOf BMP-6,demonstrated
R5968 T7804 T7803 themeOf BMP-6,negative
R5969 T7805 T7806 themeOf BMP-6,production
R3141 T4032 T4039 themeOf Act-RIA,expressed
R3142 T4033 T4038 themeOf BMP-RIB,expressed
R3143 T4034 T4037 themeOf BMP-RII,expressed
R3144 T4035 T4036 themeOf Act-RIIb,expressed
R3145 T4043 T4041 themeOf Act-RIA,expressed
R3146 T4044 T4042 themeOf BMP-RIB,expressed
R3147 T4045 T4040 themeOf BMP-RII,expressed
R3148 T4048 T4047 themeOf Act-RIA,expressed
R3149 T4049 T4046 themeOf BMP-RII,expressed
R3150 T4051 T4050 themeOf BMP-6,bind
R66 T145 T147 causeOf BMP-6,induced
R67 T145 T148 causeOf BMP-6,induced
R68 T145 T146 causeOf BMP-6,induced
R641 T106 T105 themeOf Id1,upregulation
R642 T110 T113 causeOf BMP-6,induced
R643 T110 T112 causeOf BMP-6,induced
R644 T110 T111 causeOf BMP-6,induced
R645 T114 T113 themeOf phosphorylation,induced
R646 T115 T112 themeOf phosphorylation,induced
R647 T116 T111 themeOf phosphorylation,induced
R648 T117 T114 themeOf Smad1,phosphorylation
R649 T118 T115 themeOf 5,phosphorylation
R650 T119 T116 themeOf 8,phosphorylation
R651 T120 T121 themeOf Smad,phosphorylation
R652 T121 T122 causeOf phosphorylation,followed
R653 T121 T123 causeOf phosphorylation,followed
R654 T121 T132 causeOf phosphorylation,affected
R655 T121 T133 causeOf phosphorylation,affected
R656 T124 T122 themeOf upregulation,followed
R657 T125 T123 themeOf upregulation,followed
R658 T126 T124 themeOf Id1,upregulation
R659 T127 T125 themeOf Id1,upregulation
R660 T128 T130 themeOf Id2,expression
R661 T129 T131 themeOf Id3,expression
R662 T130 T132 themeOf expression,affected
R663 T131 T133 themeOf expression,affected
R664 T144 T143 themeOf BMP-6,upregulate
R4199 T5389 T5390 causeOf BMP-6,induces
R4200 T5391 T5390 themeOf upregulation,induces
R4201 T5392 T5391 themeOf Id1,upregulation
R4202 T5393 T5395 causeOf BMP-6,induced
R4203 T5393 T5394 causeOf BMP-6,induced
R4204 T5393 T5396 causeOf BMP-6,induced
R4205 T5397 T5396 themeOf phosphorylation,induced
R4206 T5398 T5394 themeOf phosphorylation,induced
R4207 T5399 T5395 themeOf phosphorylation,induced
R4208 T5400 T5398 themeOf Smad 1,phosphorylation
R4209 T5401 T5397 themeOf 5,phosphorylation
R4210 T5402 T5399 themeOf 8,phosphorylation
R4211 T5407 T5406 themeOf Id1,upregulation
R4212 T5408 T5406 causeOf BMP-6,upregulation
R4213 T5410 T5409 themeOf Id1,up-regulation
R4214 T5410 T5411 themeOf Id1,upregulation
R4215 T5412 T5409 causeOf BMP-6,up-regulation
R4216 T5412 T5411 causeOf BMP-6,upregulation
R4217 T5412 T5413 causeOf BMP-6,changes
R4218 T5412 T5414 causeOf BMP-6,changes
R3525 T4558 T4561 causeOf BMP-6,induces
R3526 T4558 T4559 causeOf BMP-6,induces
R3527 T4558 T4560 causeOf BMP-6,induces
R3528 T4562 T4559 themeOf phosphorylation,induces
R3529 T4563 T4560 themeOf phosphorylation,induces
R3530 T4564 T4561 themeOf phosphorylation,induces
R3531 T4565 T4562 themeOf Smad1,phosphorylation
R3532 T4566 T4563 themeOf 5,phosphorylation
R3533 T4567 T4564 themeOf 8,phosphorylation
R3534 T4573 T4572 themeOf Smad1,phosphorylated
R3535 T4573 T4582 themeOf Smad1,phosphorylation
R3536 T4573 T4589 themeOf Smad1,phosphorylation
R3537 T4574 T4571 themeOf 5,phosphorylated
R3538 T4574 T4581 themeOf 5,phosphorylation
R3539 T4574 T4587 themeOf 5,phosphorylation
R3540 T4575 T4570 themeOf 8,phosphorylated
R3541 T4575 T4580 themeOf 8,phosphorylation
R3542 T4575 T4588 themeOf 8,phosphorylation
R3543 T4576 T4579 causeOf BMP-6,induced
R3544 T4576 T4577 causeOf BMP-6,induced
R3545 T4576 T4578 causeOf BMP-6,induced
R3546 T4580 T4578 themeOf phosphorylation,induced
R3547 T4581 T4577 themeOf phosphorylation,induced
R3548 T4582 T4579 themeOf phosphorylation,induced
R3549 T4583 T4586 causeOf BMP-6,induced
R3550 T4583 T4585 causeOf BMP-6,induced
R3551 T4583 T4584 causeOf BMP-6,induced
R3552 T4587 T4585 themeOf phosphorylation,induced
R3553 T4588 T4584 themeOf phosphorylation,induced
R3554 T4589 T4586 themeOf phosphorylation,induced
R3555 T4594 T4593 themeOf phospho,changes
R3556 T4595 T4594 themeOf STAT3,phospho
R10418 T13394 T13393 themeOf production,consecutive
R10419 T13395 T13394 themeOf Id1,production
R5071 T6459 T6460 themeOf BMP-6,production
R5072 T6463 T6462 themeOf BMP-6,produce
R5073 T6465 T6464 themeOf BMP-6,express
R5074 T6468 T6467 themeOf BMP-6,up-regulation
R5075 T6468 T6469 themeOf BMP-6,upregulation
R5076 T6470 T6471 themeOf BMP-6,back to baseline
R5077 T6473 T6472 themeOf upregulation,induced
R5078 T6474 T6473 themeOf BMP-6,upregulation
R5079 T6476 T6475 themeOf BMP-6,express
R5080 T6480 T6479 themeOf BMP-6,recognize
R11979 T15570 T15569 themeOf BMP-6,expression
R11980 T15575 T15567 themeOf BMP6,expression
R11981 T15575 T15574 themeOf BMP6,mRNA expression
R11982 T15576 T15568 themeOf Id1,expression
R11983 T15576 T15572 themeOf Id1,mRNA expression
R11984 T15577 T15573 themeOf Id4,mRNA expression
R11985 T15577 T15566 themeOf Id4,expression
R11986 T15578 T15571 themeOf PGK1,mRNA expression
R11987 T15578 T15565 themeOf PGK1,expression
R11988 T15582 T15580 themeOf BMP6,expression
R11989 T15583 T15581 themeOf Id1,expression
R11990 T15585 T15584 themeOf PGK1,expression
R11991 T15586 T15587 themeOf PGK1,have low expression
R11160 T14396 T14400 themeOf Expression levels,blocked
R11161 T14397 T14401 themeOf Expression levels,blocked
R11162 T14398 T14396 themeOf Id1,Expression levels
R11163 T14399 T14397 themeOf 3,Expression levels
R5907 T7691 T7690 themeOf Id1,upregulation
R5908 T7696 T7699 themeOf Id2,expression
R5909 T7697 T7698 themeOf Id3,expression
R5910 T7698 T7695 themeOf expression,induces
R5911 T7699 T7693 themeOf expression,induces
R5912 T7700 T7694 themeOf Id1,induces
R5913 T7702 T7705 themeOf Id2,expressed
R5914 T7703 T7704 themeOf Id3,expressed
R5915 T7706 T7710 themeOf Id2,expressed
R5916 T7707 T7708 themeOf Id3,expressed
R5917 T7711 T7709 themeOf Id1,expressed
R5918 T7712 T7713 causeOf BMP-6,induce
R5919 T7712 T7714 causeOf BMP-6,induce
R5920 T7715 T7713 themeOf changes,induce
R5921 T7716 T7714 themeOf changes,induce
R5922 T7717 T7715 themeOf expression,changes
R5923 T7718 T7716 themeOf expression,changes
R5924 T7719 T7717 themeOf Id2,expression
R5925 T7720 T7718 themeOf Id3,expression
R5926 T7722 T7721 themeOf Pax5,inhibitors
R5927 T7722 T7723 themeOf Pax5,forming dimers
R5928 T7722 T7725 themeOf Pax5,bind
R5929 T7723 T7721 causeOf forming dimers,inhibitors
R5930 T7723 T7724 causeOf forming dimers,making
R5931 T7725 T7724 themeOf bind,making
R5932 T7727 T7728 causeOf BMP-6,upregulation
R5933 T7729 T7728 themeOf Id1,upregulation
R5934 T7731 T7732 themeOf Id1,overexpressed
R5935 T7735 T7736 themeOf BMP-6,mRNA expression
R5936 T7736 T7734 themeOf mRNA expression,High
R5937 T7738 T7737 themeOf Id1,expression
R5877 T7656 T7667 themeOf Upregulation,mechanism
R5878 T7657 T7668 themeOf Upregulation,mechanism
R5879 T7658 T7666 themeOf Upregulation,mechanism
R5881 T7659 T7656 themeOf Id1,Upregulation
R5882 T7659 T7657 themeOf Id1,Upregulation
R5883 T7660 T7665 themeOf Smad1,phosphorylation
R5884 T7661 T7663 themeOf 5,phosphorylation
R5885 T7662 T7664 themeOf 8,phosphorylation
R782 T1083 T1084 themeOf phosphorylation,lead
R783 T1083 T1086 themeOf phosphorylation,lead
R784 T1083 T1087 themeOf phosphorylation,lead
R785 T1083 T1088 themeOf phosphorylation,lead
R786 T1083 T1089 themeOf phosphorylation,lead
R787 T1091 T1090 themeOf phosphorylation,lead
R788 T1091 T1092 themeOf phosphorylation,lead
R789 T1091 T1093 themeOf phosphorylation,lead
R790 T1091 T1094 themeOf phosphorylation,lead
R791 T1091 T1095 themeOf phosphorylation,lead
R792 T1091 T1097 themeOf phosphorylation,lead
R793 T1104 T1105 causeOf expression,induced

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T416 0-3 P22004 denotes BMP
T417 0-3 P18075 denotes BMP
T418 0-3 P12644 denotes BMP
T419 0-3 P12643 denotes BMP
T420 0-5 P22004 denotes BMP-6
T421 101-104 P41134 denotes Id1
T422 127-154 P12644 denotes Bone morphogenetic proteins
T423 127-154 P12643 denotes Bone morphogenetic proteins
T424 127-154 P18075 denotes Bone morphogenetic proteins
T425 127-154 P22004 denotes Bone morphogenetic proteins
T426 156-160 P12643 denotes BMPs
T427 156-160 P22004 denotes BMPs
T428 156-160 P12644 denotes BMPs
T429 156-160 P18075 denotes BMPs
T430 176-181 P01137 denotes TGF-β
T431 293-296 P12644 denotes BMP
T432 293-296 P22004 denotes BMP
T433 293-296 P12643 denotes BMP
T434 293-296 P18075 denotes BMP
T435 293-298 P22004 denotes BMP-6
T436 440-443 P12644 denotes BMP
T437 440-443 P22004 denotes BMP
T438 440-443 P12643 denotes BMP
T439 440-443 P18075 denotes BMP
T440 440-445 P22004 denotes BMP-6
T441 531-534 P18075 denotes BMP
T442 531-534 P12644 denotes BMP
T443 531-534 P12643 denotes BMP
T444 531-534 P22004 denotes BMP
T445 568-571 P18075 denotes BMP
T446 568-571 P12643 denotes BMP
T447 568-571 P22004 denotes BMP
T448 568-571 P12644 denotes BMP
T449 568-573 P22004 denotes BMP-6
T450 609-614 Q15797 denotes Smad1
T451 686-689 P41134 denotes Id1
T452 699-702 P41134 denotes Id1
T453 720-723 Q02363 denotes Id2
T454 728-731 Q02535 denotes Id3
T455 788-791 P12644 denotes BMP
T456 788-791 P12643 denotes BMP
T457 788-791 P18075 denotes BMP
T458 788-791 P22004 denotes BMP
T459 788-793 P22004 denotes BMP-6
T460 841-845 P15391 denotes CD19
T461 846-850 P26842 denotes CD27
T462 873-877 P15391 denotes CD19
T463 878-882 P26842 denotes CD27
T464 955-960 P29965 denotes CD40L
T465 976-979 P12644 denotes BMP
T466 976-979 P12643 denotes BMP
T467 976-979 P22004 denotes BMP
T468 976-979 P18075 denotes BMP
T469 976-981 P22004 denotes BMP-6
T470 1075-1078 P22004 denotes BMP
T471 1075-1078 P12643 denotes BMP
T472 1075-1078 P12644 denotes BMP
T473 1075-1078 P18075 denotes BMP
T474 1075-1080 P22004 denotes BMP-6
T475 1146-1152 Q13253 denotes noggin
T476 1207-1210 P22004 denotes BMP
T477 1207-1210 P12643 denotes BMP
T478 1207-1210 P12644 denotes BMP
T479 1207-1210 P18075 denotes BMP
T480 1207-1212 P22004 denotes BMP-6
T481 1287-1290 P12644 denotes BMP
T482 1287-1290 P22004 denotes BMP
T483 1287-1290 P18075 denotes BMP
T484 1287-1290 P12643 denotes BMP
T485 1287-1292 P22004 denotes BMP-6
T486 1355-1360 Q15797 denotes Smad1
T487 1396-1399 P41134 denotes Id1
T1608 1429-1457 P01137 denotes transforming growth factor β
T1609 1459-1464 P01137 denotes TGF-β
T1610 1635-1640 P01137 denotes TGF-β
T1611 1673-1700 P12643 denotes bone morphogenetic proteins
T1612 1673-1700 P22004 denotes bone morphogenetic proteins
T1613 1673-1700 P12644 denotes bone morphogenetic proteins
T1614 1673-1700 P18075 denotes bone morphogenetic proteins
T1615 1702-1706 P22004 denotes BMPs
T1616 1702-1706 P12643 denotes BMPs
T1617 1702-1706 P12644 denotes BMPs
T1618 1702-1706 P18075 denotes BMPs
T1619 1760-1764 P12643 denotes BMPs
T1620 1760-1764 P18075 denotes BMPs
T1621 1760-1764 P12644 denotes BMPs
T1622 1760-1764 P22004 denotes BMPs
T1623 2042-2047 P01137 denotes TGF-β
T1624 2230-2234 P12643 denotes BMPs
T1625 2230-2234 P18075 denotes BMPs
T1626 2230-2234 P12644 denotes BMPs
T1627 2230-2234 P22004 denotes BMPs
T1628 2307-2310 P22004 denotes BMP
T1629 2307-2310 P12644 denotes BMP
T1630 2307-2310 P12643 denotes BMP
T1631 2307-2310 P18075 denotes BMP
T1632 2436-2439 P12643 denotes BMP
T1633 2436-2439 P22004 denotes BMP
T1634 2436-2439 P18075 denotes BMP
T1635 2436-2439 P12644 denotes BMP
T1636 2436-2441 P22004 denotes BMP-6
T1637 2570-2573 P22004 denotes BMP
T1638 2570-2573 P18075 denotes BMP
T1639 2570-2573 P12644 denotes BMP
T1640 2570-2573 P12643 denotes BMP
T1641 2570-2575 P12643 denotes BMP-2
T1642 2718-2721 P12643 denotes BMP
T1643 2718-2721 P18075 denotes BMP
T1644 2718-2721 P12644 denotes BMP
T1645 2718-2721 P22004 denotes BMP
T1646 2718-2723 P22004 denotes BMP-6
T1647 2888-2891 P22004 denotes BMP
T1648 2888-2891 P12644 denotes BMP
T1649 2888-2891 P12643 denotes BMP
T1650 2888-2891 P18075 denotes BMP
T1651 2888-2893 P22004 denotes BMP-6
T1652 2910-2913 P12643 denotes BMP
T1653 2910-2913 P22004 denotes BMP
T1654 2910-2913 P18075 denotes BMP
T1655 2910-2913 P12644 denotes BMP
T1656 2973-2976 P18075 denotes BMP
T1657 2973-2976 P22004 denotes BMP
T1658 2973-2976 P12643 denotes BMP
T1659 2973-2976 P12644 denotes BMP
T1660 3145-3148 P22004 denotes BMP
T1661 3145-3148 P12644 denotes BMP
T1662 3145-3148 P12643 denotes BMP
T1663 3145-3148 P18075 denotes BMP
T1664 3145-3150 P22004 denotes BMP-6
T1665 3207-3214 Q04771 denotes Act-RIA
T1666 3216-3219 P18075 denotes BMP
T1667 3216-3219 P22004 denotes BMP
T1668 3216-3219 P12644 denotes BMP
T1669 3216-3219 P12643 denotes BMP
T1670 3216-3223 P36894 denotes BMP-RIA
T1671 3229-3232 P18075 denotes BMP
T1672 3229-3232 P22004 denotes BMP
T1673 3229-3232 P12643 denotes BMP
T1674 3229-3232 P12644 denotes BMP
T1675 3229-3236 O00238 denotes BMP-RIB
T1676 3263-3266 P22004 denotes BMP
T1677 3263-3266 P12643 denotes BMP
T1678 3263-3266 P12644 denotes BMP
T1679 3263-3266 P18075 denotes BMP
T1680 3263-3270 Q13873 denotes BMP-RII
T1681 3272-3280 P27037 denotes Act-RIIA
T1682 3285-3293 Q13705 denotes Act-RIIB
T1683 3352-3358 Q15797 denotes Smad-1
T1684 3360-3366 Q99717 denotes Smad-5
T1685 3372-3378 Q9JIW5 denotes Smad-8
T1686 3432-3437 Q13485 denotes Smad4
T1687 3545-3548 P22004 denotes BMP
T1688 3545-3548 P18075 denotes BMP
T1689 3545-3548 P12644 denotes BMP
T1690 3545-3548 P12643 denotes BMP
T1691 3545-3550 P22004 denotes BMP-6
T1692 3702-3705 P18075 denotes BMP
T1693 3702-3705 P12644 denotes BMP
T1694 3702-3705 P22004 denotes BMP
T1695 3702-3705 P12643 denotes BMP
T1696 3702-3707 P22004 denotes BMP-6
T1697 3805-3808 P12644 denotes BMP
T1698 3805-3808 P22004 denotes BMP
T1699 3805-3808 P18075 denotes BMP
T1700 3805-3808 P12643 denotes BMP
T1701 3823-3826 P18075 denotes BMP
T1702 3823-3826 P12644 denotes BMP
T1703 3823-3826 P12643 denotes BMP
T1704 3823-3826 P22004 denotes BMP
T1705 3823-3828 P22004 denotes BMP-6
T1706 3926-3929 P41134 denotes Id1
T1707 3930-3933 P47928 denotes Id4
T1708 4022-4025 P12644 denotes BMP
T1709 4022-4025 P22004 denotes BMP
T1710 4022-4025 P18075 denotes BMP
T1711 4022-4025 P12643 denotes BMP
T1712 4022-4027 P22004 denotes BMP-6
T2984 4039-4042 P22004 denotes BMP
T2985 4039-4042 P18075 denotes BMP
T2986 4039-4042 P12644 denotes BMP
T2987 4039-4042 P12643 denotes BMP
T2988 4039-4044 P22004 denotes BMP-6
T2989 4117-4120 P18075 denotes BMP
T2990 4117-4120 P12644 denotes BMP
T2991 4117-4120 P12643 denotes BMP
T2992 4117-4120 P22004 denotes BMP
T2993 4117-4122 P22004 denotes BMP-6
T2994 4210-4213 P12644 denotes BMP
T2995 4210-4213 P12643 denotes BMP
T2996 4210-4213 P22004 denotes BMP
T2997 4210-4213 P18075 denotes BMP
T2998 4210-4215 P22004 denotes BMP-6
T2999 4354-4357 P18075 denotes BMP
T3000 4354-4357 P12643 denotes BMP
T3001 4354-4357 P22004 denotes BMP
T3002 4354-4357 P12644 denotes BMP
T3003 4416-4419 P12644 denotes BMP
T3004 4416-4419 P22004 denotes BMP
T3005 4416-4419 P18075 denotes BMP
T3006 4416-4419 P12643 denotes BMP
T3007 4416-4421 P22004 denotes BMP-6
T3008 4509-4514 P29965 denotes CD40L
T3009 4545-4548 P12644 denotes BMP
T3010 4545-4548 P22004 denotes BMP
T3011 4545-4548 P12643 denotes BMP
T3012 4545-4548 P18075 denotes BMP
T3013 4545-4550 P22004 denotes BMP-6
T3014 4581-4584 P12644 denotes BMP
T3015 4581-4584 P12643 denotes BMP
T3016 4581-4584 P22004 denotes BMP
T3017 4581-4584 P18075 denotes BMP
T3018 4581-4586 P22004 denotes BMP-6
T3019 4750-4755 P29965 denotes CD40L
T3020 4800-4803 P18075 denotes BMP
T3021 4800-4803 P22004 denotes BMP
T3022 4800-4803 P12644 denotes BMP
T3023 4800-4803 P12643 denotes BMP
T3024 4800-4805 P22004 denotes BMP-6
T3025 4990-4993 P18075 denotes BMP
T3026 4990-4993 P22004 denotes BMP
T3027 4990-4993 P12644 denotes BMP
T3028 4990-4993 P12643 denotes BMP
T3029 4990-4995 P22004 denotes BMP-6
T3030 5065-5071 Q13253 denotes Noggin
T3031 5125-5128 P12644 denotes BMP
T3032 5125-5128 P22004 denotes BMP
T3033 5125-5128 P18075 denotes BMP
T3034 5125-5128 P12643 denotes BMP
T3035 5139-5142 P12643 denotes BMP
T3036 5139-5142 P12644 denotes BMP
T3037 5139-5142 P22004 denotes BMP
T3038 5139-5142 P18075 denotes BMP
T3039 5139-5146 O00238 denotes BMP-RIB
T3040 5154-5157 P12643 denotes BMP
T3041 5154-5157 P12644 denotes BMP
T3042 5154-5157 P18075 denotes BMP
T3043 5154-5157 P22004 denotes BMP
T3044 5154-5161 Q13873 denotes BMP-RII
T3045 5197-5200 P22004 denotes BMP
T3046 5197-5200 P12644 denotes BMP
T3047 5197-5200 P18075 denotes BMP
T3048 5197-5200 P12643 denotes BMP
T3049 5197-5202 P22004 denotes BMP-6
T3050 5253-5256 P12644 denotes BMP
T3051 5253-5256 P12643 denotes BMP
T3052 5253-5256 P22004 denotes BMP
T3053 5253-5256 P18075 denotes BMP
T3054 5253-5258 P22004 denotes BMP-6
T3055 5316-5320 P15391 denotes CD19
T3056 5321-5325 P26842 denotes CD27
T3057 5340-5344 P15391 denotes CD19
T3058 5345-5349 P26842 denotes CD27
T3059 5435-5439 P15391 denotes CD19
T3060 5519-5522 P12644 denotes BMP
T3061 5519-5522 P22004 denotes BMP
T3062 5519-5522 P18075 denotes BMP
T3063 5519-5522 P12643 denotes BMP
T3064 5519-5524 P22004 denotes BMP-6
T3065 5535-5538 P12644 denotes BMP
T3066 5535-5538 P18075 denotes BMP
T3067 5535-5538 P22004 denotes BMP
T3068 5535-5538 P12643 denotes BMP
T3069 5535-5540 P22004 denotes BMP-6
T3752 5772-5775 P22004 denotes BMP
T3753 5772-5775 P18075 denotes BMP
T3754 5772-5775 P12644 denotes BMP
T3755 5772-5775 P12643 denotes BMP
T3756 5772-5777 P22004 denotes BMP-6
T3757 5874-5877 P18075 denotes BMP
T3758 5874-5877 P12644 denotes BMP
T3759 5874-5877 P12643 denotes BMP
T3760 5874-5877 P22004 denotes BMP
T3761 5874-5879 P22004 denotes BMP-6
T3762 6025-6028 P12644 denotes BMP
T3763 6025-6028 P12643 denotes BMP
T3764 6025-6028 P18075 denotes BMP
T3765 6025-6028 P22004 denotes BMP
T3766 6025-6030 P22004 denotes BMP-6
T3767 6060-6063 P18075 denotes BMP
T3768 6060-6063 P12644 denotes BMP
T3769 6060-6063 P22004 denotes BMP
T3770 6060-6063 P12643 denotes BMP
T3771 6060-6065 P22004 denotes BMP-6
T3772 6184-6188 P26842 denotes CD27
T3773 6318-6321 P12643 denotes BMP
T3774 6318-6321 P22004 denotes BMP
T3775 6318-6321 P18075 denotes BMP
T3776 6318-6321 P12644 denotes BMP
T3777 6318-6323 P22004 denotes BMP-6
T3778 6368-6372 P15391 denotes CD19
T3779 6417-6421 P26842 denotes CD27
T4204 6524-6527 P22004 denotes BMP
T4205 6524-6527 P12643 denotes BMP
T4206 6524-6527 P12644 denotes BMP
T4207 6524-6527 P18075 denotes BMP
T4208 6524-6529 P22004 denotes BMP-6
T4209 6593-6596 P22004 denotes BMP
T4210 6593-6596 P12644 denotes BMP
T4211 6593-6596 P12643 denotes BMP
T4212 6593-6596 P18075 denotes BMP
T4213 6679-6683 P12643 denotes BMPs
T4214 6679-6683 P22004 denotes BMPs
T4215 6679-6683 P18075 denotes BMPs
T4216 6679-6683 P12644 denotes BMPs
T4217 6760-6763 P18075 denotes BMP
T4218 6760-6763 P12644 denotes BMP
T4219 6760-6763 P12643 denotes BMP
T4220 6760-6763 P22004 denotes BMP
T4221 6824-6831 Q04771 denotes Act-RIA
T4222 6833-6836 P12644 denotes BMP
T4223 6833-6836 P18075 denotes BMP
T4224 6833-6836 P12643 denotes BMP
T4225 6833-6836 P22004 denotes BMP
T4226 6833-6840 O00238 denotes BMP-RIB
T4227 6867-6870 P12644 denotes BMP
T4228 6867-6870 P22004 denotes BMP
T4229 6867-6870 P18075 denotes BMP
T4230 6867-6870 P12643 denotes BMP
T4231 6867-6874 Q13873 denotes BMP-RII
T4232 6879-6887 Q13705 denotes Act-RIIb
T4233 6982-6989 Q04771 denotes Act-RIA
T4234 6998-7001 P12644 denotes BMP
T4235 6998-7001 P12643 denotes BMP
T4236 6998-7001 P18075 denotes BMP
T4237 6998-7001 P22004 denotes BMP
T4238 6998-7005 O00238 denotes BMP-RIB
T4239 7031-7034 P18075 denotes BMP
T4240 7031-7034 P22004 denotes BMP
T4241 7031-7034 P12644 denotes BMP
T4242 7031-7034 P12643 denotes BMP
T4243 7031-7038 Q13873 denotes BMP-RII
T4244 7145-7152 Q04771 denotes Act-RIA
T4245 7157-7160 P18075 denotes BMP
T4246 7157-7160 P12644 denotes BMP
T4247 7157-7160 P12643 denotes BMP
T4248 7157-7160 P22004 denotes BMP
T4249 7157-7164 Q13873 denotes BMP-RII
T4250 7257-7260 P12643 denotes BMP
T4251 7257-7260 P22004 denotes BMP
T4252 7257-7260 P12644 denotes BMP
T4253 7257-7260 P18075 denotes BMP
T4254 7297-7300 P22004 denotes BMP
T4255 7297-7300 P12643 denotes BMP
T4256 7297-7300 P18075 denotes BMP
T4257 7297-7300 P12644 denotes BMP
T4258 7297-7302 P22004 denotes BMP-6
T4831 7310-7313 P22004 denotes BMP
T4832 7310-7313 P18075 denotes BMP
T4833 7310-7313 P12644 denotes BMP
T4834 7310-7313 P12643 denotes BMP
T4835 7310-7315 P22004 denotes BMP-6
T4836 7343-7348 Q15797 denotes Smad1
T4837 7526-7529 P22004 denotes BMP
T4838 7526-7529 P12643 denotes BMP
T4839 7526-7529 P12644 denotes BMP
T4840 7526-7529 P18075 denotes BMP
T4841 7526-7531 P22004 denotes BMP-6
T4842 7634-7638 P22004 denotes BMPs
T4843 7634-7638 P18075 denotes BMPs
T4844 7634-7638 P12644 denotes BMPs
T4845 7634-7638 P12643 denotes BMPs
T4846 7720-7723 P12644 denotes BMP
T4847 7720-7723 P12643 denotes BMP
T4848 7720-7723 P18075 denotes BMP
T4849 7720-7723 P22004 denotes BMP
T4850 7720-7725 P22004 denotes BMP-6
T4851 7835-7840 Q15797 denotes Smad1
T4852 7927-7930 P18075 denotes BMP
T4853 7927-7930 P22004 denotes BMP
T4854 7927-7930 P12643 denotes BMP
T4855 7927-7930 P12644 denotes BMP
T4856 7927-7932 P22004 denotes BMP-6
T4857 7970-7973 P18075 denotes BMP
T4858 7970-7973 P22004 denotes BMP
T4859 7970-7973 P12643 denotes BMP
T4860 7970-7973 P12644 denotes BMP
T4861 7970-7975 P22004 denotes BMP-6
T4862 8280-8283 P12644 denotes BMP
T4863 8280-8283 P18075 denotes BMP
T4864 8280-8283 P22004 denotes BMP
T4865 8280-8283 P12643 denotes BMP
T4866 8280-8285 P22004 denotes BMP-6
T4867 8308-8311 P18075 denotes BMP
T4868 8308-8311 P22004 denotes BMP
T4869 8308-8311 P12643 denotes BMP
T4870 8308-8311 P12644 denotes BMP
T4871 8308-8313 P22004 denotes BMP-6
T4872 8408-8413 P40763 denotes STAT3
T4873 8425-8428 Q16539 denotes p38
T4874 8425-8428 O15264 denotes p38
T4875 8425-8428 P53778 denotes p38
T4876 8425-8428 Q15759 denotes p38
T4877 8434-8437 P12644 denotes BMP
T4878 8434-8437 P22004 denotes BMP
T4879 8434-8437 P12643 denotes BMP
T4880 8434-8437 P18075 denotes BMP
T4881 8434-8439 P22004 denotes BMP-6
T5777 8480-8483 P12643 denotes BMP
T5778 8480-8483 P22004 denotes BMP
T5779 8480-8483 P18075 denotes BMP
T5780 8480-8483 P12644 denotes BMP
T5781 8480-8485 P22004 denotes BMP-6
T5782 8510-8513 P41134 denotes Id1
T5783 8553-8556 P12644 denotes BMP
T5784 8553-8556 P18075 denotes BMP
T5785 8553-8556 P12643 denotes BMP
T5786 8553-8556 P22004 denotes BMP
T5787 8553-8558 P22004 denotes BMP-6
T5788 8586-8592 Q15797 denotes Smad 1
T5789 8712-8715 P41134 denotes Ids
T5790 8909-8912 P18075 denotes BMP
T5791 8909-8912 P12644 denotes BMP
T5792 8909-8912 P12643 denotes BMP
T5793 8909-8912 P22004 denotes BMP
T5794 8909-8914 P22004 denotes BMP-6
T5795 8986-8989 P41134 denotes Id1
T5796 8990-8993 P47928 denotes Id4
T5797 9099-9102 P41134 denotes Id1
T5798 9111-9114 P12643 denotes BMP
T5799 9111-9114 P12644 denotes BMP
T5800 9111-9114 P18075 denotes BMP
T5801 9111-9114 P22004 denotes BMP
T5802 9111-9116 P22004 denotes BMP-6
T5803 9166-9169 P41134 denotes Id1
T5804 9280-9283 P12643 denotes BMP
T5805 9280-9283 P18075 denotes BMP
T5806 9280-9283 P22004 denotes BMP
T5807 9280-9283 P12644 denotes BMP
T5808 9280-9285 P22004 denotes BMP-6
T5809 9381-9384 Q02363 denotes Id2
T5810 9389-9392 Q02535 denotes Id3
T5811 9407-9410 P47928 denotes Id4
T5812 9511-9514 P12643 denotes BMP
T5813 9511-9514 P12644 denotes BMP
T5814 9511-9514 P18075 denotes BMP
T5815 9511-9514 P22004 denotes BMP
T5816 9511-9516 P22004 denotes BMP-6
T5817 9541-9544 P41134 denotes Id1
T5818 9591-9594 P41134 denotes Id1
T5819 9628-9631 P41134 denotes Id1
T5820 9711-9714 P12644 denotes BMP
T5821 9711-9714 P18075 denotes BMP
T5822 9711-9714 P12643 denotes BMP
T5823 9711-9714 P22004 denotes BMP
T5824 9711-9716 P22004 denotes BMP-6
T5825 9879-9882 Q02363 denotes Id2
T5826 9887-9890 Q02535 denotes Id3
T5827 9943-9947 P00519 denotes able
T5828 9961-9964 P41134 denotes Id1
T5829 10061-10064 P41134 denotes Id1
T5830 10126-10129 P12644 denotes BMP
T5831 10126-10129 P12643 denotes BMP
T5832 10126-10129 P18075 denotes BMP
T5833 10126-10129 P22004 denotes BMP
T5834 10126-10131 P22004 denotes BMP-6
T5835 10158-10161 Q02363 denotes Id2
T5836 10166-10169 Q02535 denotes Id3
T6717 10196-10199 P22004 denotes BMP
T6718 10196-10199 P18075 denotes BMP
T6719 10196-10199 P12644 denotes BMP
T6720 10196-10199 P12643 denotes BMP
T6721 10196-10201 P22004 denotes BMP-6
T6722 10238-10241 P18075 denotes BMP
T6723 10238-10241 P12644 denotes BMP
T6724 10238-10241 P12643 denotes BMP
T6725 10238-10241 P22004 denotes BMP
T6726 10238-10243 P22004 denotes BMP-6
T6727 10405-10408 P12644 denotes BMP
T6728 10405-10408 P12643 denotes BMP
T6729 10405-10408 P18075 denotes BMP
T6730 10405-10408 P22004 denotes BMP
T6731 10405-10410 P22004 denotes BMP-6
T6732 10479-10482 P18075 denotes BMP
T6733 10479-10482 P12643 denotes BMP
T6734 10479-10482 P12644 denotes BMP
T6735 10479-10482 P22004 denotes BMP
T6736 10479-10484 P22004 denotes BMP-6
T6737 10604-10607 P12644 denotes BMP
T6738 10604-10607 P18075 denotes BMP
T6739 10604-10607 P22004 denotes BMP
T6740 10604-10607 P12643 denotes BMP
T6741 10604-10609 P22004 denotes BMP-6
T6742 10771-10774 P22004 denotes BMP
T6743 10771-10774 P12643 denotes BMP
T6744 10771-10774 P12644 denotes BMP
T6745 10771-10774 P18075 denotes BMP
T6746 10771-10776 P22004 denotes BMP-6
T6747 10926-10929 P18075 denotes BMP
T6748 10926-10929 P12643 denotes BMP
T6749 10926-10929 P12644 denotes BMP
T6750 10926-10929 P22004 denotes BMP
T6751 10926-10931 P22004 denotes BMP-6
T6752 11080-11083 P22004 denotes BMP
T6753 11080-11083 P18075 denotes BMP
T6754 11080-11083 P12644 denotes BMP
T6755 11080-11083 P12643 denotes BMP
T6756 11080-11085 P22004 denotes BMP-6
T6757 11194-11197 P18075 denotes BMP
T6758 11194-11197 P12644 denotes BMP
T6759 11194-11197 P12643 denotes BMP
T6760 11194-11197 P22004 denotes BMP
T6761 11194-11199 P22004 denotes BMP-6
T6762 11294-11297 P12643 denotes BMP
T6763 11294-11297 P22004 denotes BMP
T6764 11294-11297 P12644 denotes BMP
T6765 11294-11297 P18075 denotes BMP
T6766 11294-11299 P22004 denotes BMP-6
T6767 11413-11416 P12644 denotes BMP
T6768 11413-11416 P18075 denotes BMP
T6769 11413-11416 P12643 denotes BMP
T6770 11413-11416 P22004 denotes BMP
T6771 11413-11418 P22004 denotes BMP-6
T6772 11465-11468 P12644 denotes BMP
T6773 11465-11468 P22004 denotes BMP
T6774 11465-11468 P18075 denotes BMP
T6775 11465-11468 P12643 denotes BMP
T6776 11465-11470 P22004 denotes BMP-6
T9860 12278-12281 P22004 denotes BMP
T9861 12278-12281 P12643 denotes BMP
T9862 12278-12281 P12644 denotes BMP
T9863 12278-12283 P22004 denotes BMP-6
T9864 12394-12397 P12643 denotes BMP
T9865 12394-12397 P12644 denotes BMP
T9866 12394-12397 P22004 denotes BMP
T9867 12394-12397 P18075 denotes BMP
T9868 12394-12399 P22004 denotes BMP-6
T9869 12467-12473 Q13253 denotes Noggin
T9870 12517-12523 Q13253 denotes Noggin
T9871 12542-12545 P18075 denotes BMP
T9872 12542-12545 P12644 denotes BMP
T9873 12542-12545 P12643 denotes BMP
T9874 12542-12545 P22004 denotes BMP
T9875 12542-12547 P22004 denotes BMP-6
T9876 12608-12611 P12644 denotes BMP
T9877 12608-12611 P12643 denotes BMP
T9878 12608-12611 P22004 denotes BMP
T9879 12608-12611 P18075 denotes BMP
T9880 12608-12615 O00238 denotes BMP-RIB
T9881 12623-12626 P12643 denotes BMP
T9882 12623-12626 P22004 denotes BMP
T9883 12623-12626 P18075 denotes BMP
T9884 12623-12626 P12644 denotes BMP
T9885 12623-12630 Q13873 denotes BMP-RII
T9886 12700-12703 P12644 denotes BMP
T9887 12700-12703 P22004 denotes BMP
T9888 12700-12703 P12643 denotes BMP
T9889 12700-12703 P18075 denotes BMP
T9890 12700-12705 P22004 denotes BMP-6
T9891 12825-12829 P18075 denotes BMPs
T9892 12825-12829 P12644 denotes BMPs
T9893 12825-12829 P12643 denotes BMPs
T9894 12825-12829 P22004 denotes BMPs
T9895 12854-12858 P18075 denotes BMPs
T9896 12854-12858 P12643 denotes BMPs
T9897 12854-12858 P12644 denotes BMPs
T9898 12854-12858 P22004 denotes BMPs
T9899 13121-13124 P22004 denotes BMP
T9900 13121-13124 P12644 denotes BMP
T9901 13121-13124 P12643 denotes BMP
T9902 13121-13124 P18075 denotes BMP
T9903 13121-13126 P22004 denotes BMP-6
T9904 13188-13191 P22004 denotes BMP
T9905 13188-13191 P12644 denotes BMP
T9906 13188-13191 P12643 denotes BMP
T9907 13188-13191 P18075 denotes BMP
T9908 13188-13193 P12643 denotes BMP-2
T9909 13259-13262 P12644 denotes BMP
T9910 13259-13262 P22004 denotes BMP
T9911 13259-13262 P12643 denotes BMP
T9912 13259-13262 P18075 denotes BMP
T9913 13370-13373 P12644 denotes BMP
T9914 13370-13373 P22004 denotes BMP
T9915 13370-13373 P12643 denotes BMP
T9916 13370-13373 P18075 denotes BMP
T9917 13370-13375 P12644 denotes BMP-4
T9918 13466-13470 P12644 denotes BMPs
T9919 13466-13470 P12643 denotes BMPs
T9920 13466-13470 P18075 denotes BMPs
T9921 13466-13470 P22004 denotes BMPs
T9922 13566-13569 P12643 denotes BMP
T9923 13566-13569 P18075 denotes BMP
T9924 13566-13569 P12644 denotes BMP
T9925 13566-13569 P22004 denotes BMP
T9926 13566-13571 P22004 denotes BMP-6
T9927 13626-13629 P12643 denotes BMP
T9928 13626-13629 P22004 denotes BMP
T9929 13626-13629 P12644 denotes BMP
T9930 13626-13629 P18075 denotes BMP
T9931 13727-13730 P12644 denotes BMP
T9932 13727-13730 P18075 denotes BMP
T9933 13727-13730 P12643 denotes BMP
T9934 13727-13730 P22004 denotes BMP
T9935 13727-13747 Q13873 denotes BMP type I receptors
T9936 13748-13755 Q04771 denotes Act-RIA
T9937 13760-13763 P18075 denotes BMP
T9938 13760-13763 P22004 denotes BMP
T9939 13760-13763 P12643 denotes BMP
T9940 13760-13763 P12644 denotes BMP
T9941 13760-13767 O00238 denotes BMP-RIB
T9942 13795-13798 P18075 denotes BMP
T9943 13795-13798 P12643 denotes BMP
T9944 13795-13798 P22004 denotes BMP
T9945 13795-13798 P12644 denotes BMP
T9946 13795-13802 Q13873 denotes BMP-RII
T9947 13807-13815 Q13705 denotes Act-RIIb
T9948 13855-13859 P18075 denotes BMPs
T9949 13855-13859 P22004 denotes BMPs
T9950 13855-13859 P12644 denotes BMPs
T9951 13855-13859 P12643 denotes BMPs
T9952 13871-13874 P18075 denotes BMP
T9953 13871-13874 P22004 denotes BMP
T9954 13871-13874 P12644 denotes BMP
T9955 13871-13874 P12643 denotes BMP
T9956 13871-13876 P22004 denotes BMP-6
T9957 13905-13908 P22004 denotes BMP
T9958 13905-13908 P12644 denotes BMP
T9959 13905-13908 P12643 denotes BMP
T9960 13905-13908 P18075 denotes BMP
T9961 13905-13910 P22004 denotes BMP-6
T9962 14070-14074 P22004 denotes BMPs
T9963 14070-14074 P18075 denotes BMPs
T9964 14070-14074 P12644 denotes BMPs
T9965 14070-14074 P12643 denotes BMPs
T9966 14197-14200 P12644 denotes BMP
T9967 14197-14200 P18075 denotes BMP
T9968 14197-14200 P12643 denotes BMP
T9969 14197-14200 P22004 denotes BMP
T9970 14197-14202 P12643 denotes BMP-2
T9971 14242-14247 P40763 denotes STAT3
T9972 14341-14344 P22004 denotes BMP
T9973 14341-14344 P18075 denotes BMP
T9974 14341-14344 P12644 denotes BMP
T9975 14341-14344 P12643 denotes BMP
T9976 14341-14346 P12643 denotes BMP-2
T9977 14396-14399 O15264 denotes p38
T9978 14396-14399 P53778 denotes p38
T9979 14396-14399 Q15759 denotes p38
T9980 14396-14399 Q16539 denotes p38
T9981 14431-14434 Q16539 denotes p38
T9982 14431-14434 P53778 denotes p38
T9983 14431-14434 O15264 denotes p38
T9984 14431-14434 Q15759 denotes p38
T9985 14436-14441 P40763 denotes STAT3
T9986 14446-14451 Q15797 denotes Smad1
T9987 14476-14479 P18075 denotes BMP
T9988 14476-14479 P22004 denotes BMP
T9989 14476-14479 P12644 denotes BMP
T9990 14476-14479 P12643 denotes BMP
T9991 14529-14533 P22004 denotes BMPs
T9992 14529-14533 P12644 denotes BMPs
T9993 14529-14533 P12643 denotes BMPs
T9994 14529-14533 P18075 denotes BMPs
T9995 14638-14642 P00519 denotes able
T9996 14653-14656 P12644 denotes BMP
T9997 14653-14656 P22004 denotes BMP
T9998 14653-14656 P18075 denotes BMP
T9999 14653-14656 P12643 denotes BMP
T10000 14653-14658 P22004 denotes BMP-6
T10001 14708-14713 P40763 denotes STAT3
T10002 14717-14720 P53778 denotes p38
T10003 14717-14720 Q16539 denotes p38
T10004 14717-14720 Q15759 denotes p38
T10005 14717-14720 O15264 denotes p38
T10006 14797-14802 Q15797 denotes Smad1
T10007 14867-14871 P22004 denotes BMPs
T10008 14867-14871 P12644 denotes BMPs
T10009 14867-14871 P12643 denotes BMPs
T10010 14867-14871 P18075 denotes BMPs
T10011 14904-14909 Q15797 denotes Smad1
T10012 15098-15102 P18075 denotes BMPs
T10013 15098-15102 P12644 denotes BMPs
T10014 15098-15102 P22004 denotes BMPs
T10015 15098-15102 P12643 denotes BMPs
T10016 15137-15140 P41134 denotes Id1
T10017 15145-15150 Q15797 denotes Smad1
T10018 15196-15199 P22004 denotes BMP
T10019 15196-15199 P18075 denotes BMP
T10020 15196-15199 P12643 denotes BMP
T10021 15196-15199 P12644 denotes BMP
T10022 15196-15201 P22004 denotes BMP-6
T10023 15261-15263 P41134 denotes Id
T10024 15437-15440 P41134 denotes Id1
T10025 15444-15447 P18075 denotes BMP
T10026 15444-15447 P12643 denotes BMP
T10027 15444-15447 P22004 denotes BMP
T10028 15444-15447 P12644 denotes BMP
T10029 15444-15449 P22004 denotes BMP-6
T10030 15487-15490 Q02363 denotes Id2
T10031 15491-15494 P47928 denotes Id4
T10032 15593-15596 P41134 denotes Id1
T10033 15626-15629 Q02363 denotes Id2
T10034 15634-15637 Q02535 denotes Id3
T10035 15685-15688 P41134 denotes Id1
T10036 15943-15946 P41134 denotes Id1
T10037 16061-16066 P01137 denotes TGF-β
T10038 16119-16122 Q02363 denotes Id2
T10039 16127-16130 Q02535 denotes Id3
T10040 16159-16162 P41134 denotes Id1
T10041 16243-16248 P01137 denotes TGF-β
T10042 16265-16267 P41134 denotes Id
T10043 16290-16293 Q02363 denotes Id2
T10044 16298-16301 Q02535 denotes Id3
T10045 16327-16329 P41134 denotes Id
T10046 16409-16412 Q02363 denotes Id2
T10047 16417-16420 Q02535 denotes Id3
T10048 16473-16476 P41134 denotes Id1
T10049 16506-16509 P12643 denotes BMP
T10050 16506-16509 P18075 denotes BMP
T10051 16506-16509 P12644 denotes BMP
T10052 16506-16509 P22004 denotes BMP
T10053 16506-16511 P22004 denotes BMP-6
T10054 16576-16579 Q02363 denotes Id2
T10055 16584-16587 Q02535 denotes Id3
T10056 16609-16611 P41134 denotes Id
T10057 16700-16702 P41134 denotes Id
T10058 16766-16770 Q02548 denotes Pax5
T10059 16907-16911 Q02548 denotes Pax5
T10060 16916-16918 P41134 denotes Id
T10061 17201-17204 P12643 denotes BMP
T10062 17201-17204 P18075 denotes BMP
T10063 17201-17204 P22004 denotes BMP
T10064 17201-17204 P12644 denotes BMP
T10065 17201-17206 P22004 denotes BMP-6
T10066 17251-17254 P41134 denotes Id1
T10067 17303-17305 P41134 denotes Id
T10068 17408-17413 P01137 denotes TGF-β
T10069 17433-17435 P41134 denotes Id
T10070 17608-17610 P41134 denotes Id
T10071 17679-17682 P41134 denotes Id1
T10072 17850-17853 P18075 denotes BMP
T10073 17850-17853 P22004 denotes BMP
T10074 17850-17853 P12643 denotes BMP
T10075 17850-17853 P12644 denotes BMP
T10076 17850-17855 P22004 denotes BMP-6
T10077 18006-18009 P12643 denotes BMP
T10078 18006-18009 P12644 denotes BMP
T10079 18006-18009 P22004 denotes BMP
T10080 18006-18009 P18075 denotes BMP
T10081 18006-18011 P22004 denotes BMP-6
T10082 18158-18161 P41134 denotes Id1
T10083 18302-18305 P22004 denotes BMP
T10084 18302-18305 P18075 denotes BMP
T10085 18302-18305 P12644 denotes BMP
T10086 18302-18305 P12643 denotes BMP
T10087 18302-18307 P22004 denotes BMP-6
T10088 18402-18405 P41134 denotes Id1
T10089 18410-18413 Q02535 denotes Id3
T10090 18523-18525 P41134 denotes Id
T10091 18691-18693 P41134 denotes Id
T10092 18759-18761 P41134 denotes Id
T10093 18799-18802 P12643 denotes BMP
T10094 18799-18802 P18075 denotes BMP
T10095 18799-18802 P22004 denotes BMP
T10096 18799-18802 P12644 denotes BMP
T10097 18799-18804 P22004 denotes BMP-6
T10098 18866-18869 P22004 denotes BMP
T10099 18866-18869 P12643 denotes BMP
T10100 18866-18869 P18075 denotes BMP
T10101 18866-18869 P12644 denotes BMP
T10102 18866-18871 P22004 denotes BMP-6
T10103 19027-19030 P12643 denotes BMP
T10104 19027-19030 P12644 denotes BMP
T10105 19027-19030 P22004 denotes BMP
T10106 19027-19030 P18075 denotes BMP
T10107 19027-19032 P22004 denotes BMP-6
T10108 19138-19141 P12644 denotes BMP
T10109 19138-19141 P18075 denotes BMP
T10110 19138-19141 P12643 denotes BMP
T10111 19138-19141 P22004 denotes BMP
T10112 19138-19143 P22004 denotes BMP-6
T10113 19238-19241 P12643 denotes BMP
T10114 19238-19241 P12644 denotes BMP
T10115 19238-19241 P22004 denotes BMP
T10116 19238-19241 P18075 denotes BMP
T10117 19238-19243 P22004 denotes BMP-6
T10118 19389-19392 P12644 denotes BMP
T10119 19389-19392 P12643 denotes BMP
T10120 19389-19392 P18075 denotes BMP
T10121 19389-19392 P22004 denotes BMP
T10122 19389-19394 P22004 denotes BMP-6
T10123 19445-19448 P22004 denotes BMP
T10124 19445-19448 P12643 denotes BMP
T10125 19445-19448 P18075 denotes BMP
T10126 19445-19448 P12644 denotes BMP
T10127 19445-19450 P22004 denotes BMP-6
T10128 19549-19552 P22004 denotes BMP
T10129 19549-19552 P12643 denotes BMP
T10130 19549-19552 P12644 denotes BMP
T10131 19549-19552 P18075 denotes BMP
T10132 19549-19554 P22004 denotes BMP-6
T10133 19674-19677 P18075 denotes BMP
T10134 19674-19677 P12644 denotes BMP
T10135 19674-19677 P12643 denotes BMP
T10136 19674-19677 P22004 denotes BMP
T10137 19674-19679 P22004 denotes BMP-6
T10138 19765-19768 P12643 denotes BMP
T10139 19765-19768 P18075 denotes BMP
T10140 19765-19768 P22004 denotes BMP
T10141 19765-19768 P12644 denotes BMP
T10142 19765-19770 P22004 denotes BMP-6
T10143 19854-19857 P18075 denotes BMP
T10144 19854-19857 P12643 denotes BMP
T10145 19854-19857 P12644 denotes BMP
T10146 19854-19857 P22004 denotes BMP
T10147 19854-19859 P22004 denotes BMP-6
T10148 19974-19977 P18075 denotes BMP
T10149 19974-19977 P22004 denotes BMP
T10150 19974-19977 P12643 denotes BMP
T10151 19974-19977 P12644 denotes BMP
T10152 19974-19979 P22004 denotes BMP-6
T10153 20055-20058 P22004 denotes BMP
T10154 20055-20058 P18075 denotes BMP
T10155 20055-20058 P12644 denotes BMP
T10156 20055-20058 P12643 denotes BMP
T10157 20055-20060 P22004 denotes BMP-6
T10158 20151-20154 P12643 denotes BMP
T10159 20151-20154 P12644 denotes BMP
T10160 20151-20154 P22004 denotes BMP
T10161 20151-20154 P18075 denotes BMP
T10162 20151-20156 P22004 denotes BMP-6
T10163 20272-20276 P18075 denotes BMPs
T10164 20272-20276 P12644 denotes BMPs
T10165 20272-20276 P22004 denotes BMPs
T10166 20272-20276 P12643 denotes BMPs
T10167 20358-20361 P22004 denotes BMP
T10168 20358-20361 P12643 denotes BMP
T10169 20358-20361 P18075 denotes BMP
T10170 20358-20361 P12644 denotes BMP
T10171 20358-20363 P22004 denotes BMP-6
T10172 20447-20452 P01137 denotes TGF-β
T10173 20611-20615 P12644 denotes BMPs
T10174 20611-20615 P12643 denotes BMPs
T10175 20611-20615 P22004 denotes BMPs
T10176 20611-20615 P18075 denotes BMPs
T10177 20688-20691 P18075 denotes BMP
T10178 20688-20691 P12643 denotes BMP
T10179 20688-20691 P22004 denotes BMP
T10180 20688-20691 P12644 denotes BMP
T10181 20688-20693 P22004 denotes BMP-6
T10182 20844-20849 P01137 denotes TGF-β
T10183 20887-20890 P12643 denotes BMP
T10184 20887-20890 P22004 denotes BMP
T10185 20887-20890 P18075 denotes BMP
T10186 20887-20890 P12644 denotes BMP
T10187 20887-20892 P12644 denotes BMP-4
T10188 20939-20942 P12643 denotes BMP
T10189 20939-20942 P12644 denotes BMP
T10190 20939-20942 P18075 denotes BMP
T10191 20939-20942 P22004 denotes BMP
T10192 21033-21036 P22004 denotes BMP
T10193 21033-21036 P18075 denotes BMP
T10194 21033-21036 P12643 denotes BMP
T10195 21033-21036 P12644 denotes BMP
T10196 21033-21038 P22004 denotes BMP-6
T10197 21074-21078 P00519 denotes able
T10198 21089-21092 P12643 denotes BMP
T10199 21089-21092 P12644 denotes BMP
T10200 21089-21092 P18075 denotes BMP
T10201 21089-21092 P22004 denotes BMP
T10202 21089-21094 P22004 denotes BMP-6
T10203 21133-21136 P01730 denotes CD4
T10204 21141-21144 P01732 denotes CD8
T10205 21141-21144 P10966 denotes CD8
T10206 21187-21190 P07766 denotes CD3
T10207 21187-21190 P20963 denotes CD3
T10208 21187-21190 P04234 denotes CD3
T10209 21187-21190 P09693 denotes CD3
T10210 21200-21204 P10747 denotes CD28
T10211 21315-21318 P12643 denotes BMP
T10212 21315-21318 P12644 denotes BMP
T10213 21315-21318 P22004 denotes BMP
T10214 21315-21318 P18075 denotes BMP
T10215 21315-21320 P22004 denotes BMP-6
T10216 21481-21484 P12644 denotes BMP
T10217 21481-21484 P12643 denotes BMP
T10218 21481-21484 P22004 denotes BMP
T10219 21481-21484 P18075 denotes BMP
T10220 21481-21486 P22004 denotes BMP-6
T10221 21644-21647 P12644 denotes BMP
T10222 21644-21647 P12643 denotes BMP
T10223 21644-21647 P22004 denotes BMP
T10224 21644-21647 P18075 denotes BMP
T10225 21644-21649 P22004 denotes BMP-6
T10226 21715-21718 P12643 denotes BMP
T10227 21715-21718 P12644 denotes BMP
T10228 21715-21718 P18075 denotes BMP
T10229 21715-21718 P22004 denotes BMP
T10230 21715-21720 P22004 denotes BMP-6
T10231 21764-21767 P12643 denotes BMP
T10232 21764-21767 P12644 denotes BMP
T10233 21764-21767 P22004 denotes BMP
T10234 21764-21767 P18075 denotes BMP
T10235 21764-21769 P22004 denotes BMP-6
T10236 21812-21815 P22004 denotes BMP
T10237 21812-21815 P12643 denotes BMP
T10238 21812-21815 P18075 denotes BMP
T10239 21812-21815 P12644 denotes BMP
T10240 21812-21817 P22004 denotes BMP-6
T10241 22038-22041 P18075 denotes BMP
T10242 22038-22041 P22004 denotes BMP
T10243 22038-22041 P12643 denotes BMP
T10244 22038-22041 P12644 denotes BMP
T10245 22038-22043 P22004 denotes BMP-6
T10246 22114-22117 P18075 denotes BMP
T10247 22114-22117 P12644 denotes BMP
T10248 22114-22117 P12643 denotes BMP
T10249 22114-22117 P22004 denotes BMP
T10250 22114-22119 P22004 denotes BMP-6
T13510 22206-22209 P22004 denotes BMP
T13511 22206-22209 P18075 denotes BMP
T13512 22206-22209 P12643 denotes BMP
T13513 22206-22209 P12644 denotes BMP
T13514 22206-22211 P22004 denotes BMP-6
T13515 22319-22322 P41134 denotes Id1
T13516 22360-22363 P12644 denotes BMP
T13517 22360-22363 P18075 denotes BMP
T13518 22360-22363 P12643 denotes BMP
T13519 22360-22363 P22004 denotes BMP
T13520 22360-22365 P22004 denotes BMP-6
T13521 22479-22484 P29965 denotes CD40L
T13522 22500-22503 P18075 denotes BMP
T13523 22500-22503 P22004 denotes BMP
T13524 22500-22503 P12644 denotes BMP
T13525 22500-22503 P12643 denotes BMP
T13526 22500-22505 P22004 denotes BMP-6
T13527 22651-22654 P12644 denotes BMP
T13528 22651-22654 P18075 denotes BMP
T13529 22651-22654 P22004 denotes BMP
T13530 22651-22654 P12643 denotes BMP
T13531 22651-22656 P22004 denotes BMP-6
T13900 23147-23151 P15391 denotes CD19
T14149 23957-23960 P12643 denotes BMP
T14150 23957-23960 P22004 denotes BMP
T14151 23957-23960 P12644 denotes BMP
T14152 23957-23960 P18075 denotes BMP
T14153 23957-23962 P22004 denotes BMP-6
T14154 24006-24009 P22004 denotes BMP
T14155 24006-24009 P18075 denotes BMP
T14156 24006-24009 P12644 denotes BMP
T14157 24006-24009 P12643 denotes BMP
T14158 24006-24013 O00238 denotes BMP-RIB
T14159 24014-24019 P36898 denotes ALK-6
T14160 24046-24053 Q13873 denotes BMPR-II
T14161 24098-24104 Q13253 denotes Noggin
T14162 24311-24315 P25942 denotes CD40
T14163 24311-24322 P29965 denotes CD40 ligand
T14164 24324-24329 P29965 denotes CD40L
T14661 24485-24488 P12643 denotes BMP
T14662 24485-24488 P12644 denotes BMP
T14663 24485-24488 P18075 denotes BMP
T14664 24485-24488 P22004 denotes BMP
T14665 24499-24506 Q04771 denotes Act-RIA
T14666 24508-24511 P12643 denotes BMP
T14667 24508-24511 P12644 denotes BMP
T14668 24508-24511 P18075 denotes BMP
T14669 24508-24511 P22004 denotes BMP
T14670 24508-24515 O00238 denotes BMP-RIB
T14671 24517-24524 Q13873 denotes BMPR-II
T14672 24526-24534 P27037 denotes Act-RIIA
T14673 24539-24547 Q13705 denotes Act-RIIb
T14674 24615-24618 P12643 denotes BMP
T14675 24615-24618 P12644 denotes BMP
T14676 24615-24618 P22004 denotes BMP
T14677 24615-24618 P18075 denotes BMP
T14678 24615-24620 P22004 denotes BMP-6
T14679 24696-24699 P12643 denotes BMP
T14680 24696-24699 P12644 denotes BMP
T14681 24696-24699 P22004 denotes BMP
T14682 24696-24699 P18075 denotes BMP
T14683 24696-24701 P22004 denotes BMP-6
T14684 24758-24761 P18075 denotes BMP
T14685 24758-24761 P12644 denotes BMP
T14686 24758-24761 P22004 denotes BMP
T14687 24758-24761 P12643 denotes BMP
T14688 24758-24763 P22004 denotes BMP-6
T14689 24789-24792 P18075 denotes BMP
T14690 24789-24792 P12644 denotes BMP
T14691 24789-24792 P22004 denotes BMP
T14692 24789-24792 P12643 denotes BMP
T14693 24789-24794 P22004 denotes BMP-6
T14694 24856-24859 P22004 denotes BMP
T14695 24856-24859 P12644 denotes BMP
T14696 24856-24859 P12643 denotes BMP
T14697 24856-24859 P18075 denotes BMP
T14698 24856-24861 P22004 denotes BMP-6
T14699 24931-24934 P22004 denotes BMP
T14700 24931-24934 P12644 denotes BMP
T14701 24931-24934 P12643 denotes BMP
T14702 24931-24934 P18075 denotes BMP
T14703 24987-24992 Q15797 denotes Smad1
T14704 25077-25080 P41134 denotes Id1
T14705 25427-25434 P60709 denotes β-actin
T14706 25512-25516 P15391 denotes CD19
T14707 25526-25530 P15391 denotes CD19
T14708 25584-25588 P15391 denotes CD19
T14709 25641-25645 P26842 denotes CD27
T15142 25747-25751 P15391 denotes CD19
T15143 25752-25756 P26842 denotes CD27
T15144 25761-25765 P15391 denotes CD19
T15145 25766-25770 P26842 denotes CD27
T15146 25804-25808 P15391 denotes CD19
T15147 25826-25830 P26842 denotes CD27
T15148 25838-25842 P15391 denotes CD19
T15474 26111-26113 P0A7Z4 denotes pH
T15475 26948-26951 P41134 denotes Id1
T15476 26953-26956 Q02363 denotes Id2
T15477 26961-26964 Q02535 denotes Id3
T15478 27033-27040 P60709 denotes β-actin
T15841 27107-27110 P22004 denotes BMP
T15842 27107-27110 P18075 denotes BMP
T15843 27107-27110 P12644 denotes BMP
T15844 27107-27110 P12643 denotes BMP
T15845 27107-27112 P22004 denotes BMP-6
T15846 27174-27177 P18075 denotes BMP
T15847 27174-27177 P12643 denotes BMP
T15848 27174-27177 P12644 denotes BMP
T15849 27174-27177 P22004 denotes BMP
T15850 27174-27179 P22004 denotes BMP-6
T15851 27684-27688 P22004 denotes BMP6
T15852 27690-27693 P41134 denotes Id1
T15853 27694-27697 P47928 denotes Id4
T15854 27702-27706 P00558 denotes PGK1
T15855 27896-27899 P22004 denotes BMP
T15856 27896-27899 P12644 denotes BMP
T15857 27896-27899 P18075 denotes BMP
T15858 27896-27899 P12643 denotes BMP
T15859 27896-27901 P22004 denotes BMP-6
T15860 27913-27916 P41134 denotes ID1
T15861 28070-28074 P22004 denotes BMP6
T15862 28107-28110 P41134 denotes Id1
T15863 28236-28240 P00558 denotes PGK1
T15864 28242-28246 P00558 denotes PGK1
T16343 28494-28498 P15391 denotes CD19
T9826 11574-11577 P12643 denotes BMP
T9827 11574-11577 P12644 denotes BMP
T9828 11574-11577 P18075 denotes BMP
T9829 11574-11577 P22004 denotes BMP
T9830 11700-11704 P22004 denotes BMPs
T9831 11700-11704 P12644 denotes BMPs
T9832 11700-11704 P12643 denotes BMPs
T9833 11700-11704 P18075 denotes BMPs
T9834 11836-11839 P22004 denotes BMP
T9835 11836-11839 P18075 denotes BMP
T9836 11836-11839 P12643 denotes BMP
T9837 11836-11839 P12644 denotes BMP
T9838 11836-11841 P22004 denotes BMP-6
T9839 11862-11866 P15391 denotes CD19
T9840 11891-11894 P12643 denotes BMP
T9841 11891-11894 P12644 denotes BMP
T9842 11891-11894 P22004 denotes BMP
T9843 11891-11894 P18075 denotes BMP
T9844 11891-11896 P22004 denotes BMP-6
T9845 11919-11923 P26842 denotes CD27
T9846 12005-12008 P18075 denotes BMP
T9847 12005-12008 P22004 denotes BMP
T9848 12005-12008 P12644 denotes BMP
T9849 12005-12008 P12643 denotes BMP
T9850 12005-12010 P22004 denotes BMP-6
T9851 12050-12056 Q15797 denotes Smad-1
T9852 12095-12098 P12643 denotes BMP
T9853 12095-12098 P12644 denotes BMP
T9854 12095-12098 P18075 denotes BMP
T9855 12095-12098 P22004 denotes BMP
T9856 12095-12100 P22004 denotes BMP-6
T9857 12174-12177 P41134 denotes Id1
T9858 12198-12201 P41134 denotes Id1
T9859 12278-12281 P18075 denotes BMP

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T13385 22293-22304 Positive_regulation denotes consecutive
T13386 22305-22315 Gene_expression denotes production
T13387 22319-22322 Protein denotes Id1
T13388 22360-22365 Protein denotes BMP-6
T13389 22479-22484 Protein denotes CD40L
T13390 22500-22505 Protein denotes BMP-6
T13391 22651-22656 Protein denotes BMP-6
T57 0-5 Protein denotes BMP-6
T58 47-56 Positive_regulation denotes induction
T59 65-80 Phosphorylation denotes phosphorylation
T60 85-97 Positive_regulation denotes upregulation
T61 101-104 Protein denotes Id1
T62 176-181 Protein denotes TGF-β
T63 293-298 Protein denotes BMP-6
T64 440-445 Protein denotes BMP-6
T65 523-530 Gene_expression denotes express
T66 568-573 Protein denotes BMP-6
T67 582-589 Positive_regulation denotes induced
T68 590-605 Phosphorylation denotes phosphorylation
T69 609-614 Protein denotes Smad1
T70 615-616 Protein denotes 5
T71 617-618 Protein denotes 8 true
T72 633-637 Protein denotes Smad true
T73 638-653 Phosphorylation denotes phosphorylation
T74 658-666 Positive_regulation denotes followed
T75 670-682 Positive_regulation denotes upregulation
T76 686-689 Protein denotes Id1
T77 699-702 Protein denotes Id1
T78 720-723 Protein denotes Id2
T79 728-731 Protein denotes Id3
T80 732-742 Gene_expression denotes expression
T81 751-759 Regulation denotes affected
T82 788-793 Protein denotes BMP-6
T83 841-845 Protein denotes CD19
T84 846-850 Protein denotes CD27
T85 873-877 Protein denotes CD19
T86 878-882 Protein denotes CD27
T87 955-960 Protein denotes CD40L
T88 976-981 Protein denotes BMP-6
T89 1075-1080 Protein denotes BMP-6
T90 1146-1152 Protein denotes noggin
T91 1196-1206 Positive_regulation denotes upregulate
T92 1207-1212 Protein denotes BMP-6
T93 1287-1292 Protein denotes BMP-6
T94 1328-1335 Positive_regulation denotes induced
T95 1336-1351 Phosphorylation denotes phosphorylation
T96 1355-1360 Protein denotes Smad1
T97 1361-1362 Protein denotes 5
T98 1363-1364 Protein denotes 8
T99 1365-1373 Positive_regulation denotes followed
T100 1380-1392 Positive_regulation denotes upregulation
T101 1396-1399 Protein denotes Id1
T2577 4039-4044 Protein denotes BMP-6
T2578 4117-4122 Protein denotes BMP-6
T2579 4210-4215 Protein denotes BMP-6
T2580 4416-4421 Protein denotes BMP-6
T2581 4509-4514 Protein denotes CD40L
T2582 4534-4541 Negative_regulation denotes absence
T2583 4545-4550 Protein denotes BMP-6
T2584 4581-4586 Protein denotes BMP-6
T2585 4750-4755 Protein denotes CD40L
T2586 4800-4805 Protein denotes BMP-6
T2587 4990-4995 Protein denotes BMP-6
T2588 5065-5071 Protein denotes Noggin
T2589 5139-5146 Protein denotes BMP-RIB
T2590 5154-5161 Protein denotes BMP-RII
T2591 5186-5193 Regulation denotes effects
T2592 5197-5202 Protein denotes BMP-6
T2593 5253-5258 Protein denotes BMP-6
T2594 5316-5320 Protein denotes CD19
T2595 5321-5325 Protein denotes CD27
T2596 5340-5344 Protein denotes CD19
T2597 5345-5349 Protein denotes CD27
T2598 5435-5439 Protein denotes CD19
T2599 5519-5524 Protein denotes BMP-6
T2600 5535-5540 Protein denotes BMP-6
T3562 5772-5777 Protein denotes BMP-6
T3563 5874-5879 Protein denotes BMP-6
T3564 6025-6030 Protein denotes BMP-6
T3565 6060-6065 Protein denotes BMP-6
T3566 6184-6188 Protein denotes CD27
T3567 6318-6323 Protein denotes BMP-6
T3568 6368-6372 Protein denotes CD19
T3569 6417-6421 Protein denotes CD27
T4013 6516-6523 Gene_expression denotes express
T4014 6524-6529 Protein denotes BMP-6
T4015 6824-6831 Protein denotes Act-RIA
T4016 6833-6840 Protein denotes BMP-RIB
T4017 6867-6874 Protein denotes BMP-RII
T4018 6879-6887 Protein denotes Act-RIIb
T4019 6892-6901 Gene_expression denotes expressed
T4020 6951-6960 Gene_expression denotes expressed
T4021 6982-6989 Protein denotes Act-RIA
T4022 6998-7005 Protein denotes BMP-RIB
T4023 7031-7038 Protein denotes BMP-RII
T4024 7135-7144 Gene_expression denotes expressed
T4025 7145-7152 Protein denotes Act-RIA
T4026 7157-7164 Protein denotes BMP-RII
T4027 7292-7296 Binding denotes bind
T4028 7297-7302 Protein denotes BMP-6
T5345 8480-8485 Protein denotes BMP-6
T5346 8486-8493 Positive_regulation denotes induces
T5347 8494-8506 Positive_regulation denotes upregulation
T5348 8510-8513 Protein denotes Id1
T5349 8553-8558 Protein denotes BMP-6
T5350 8559-8566 Positive_regulation denotes induced
T5351 8567-8582 Phosphorylation denotes phosphorylation
T5352 8586-8592 Protein denotes Smad 1
T5353 8593-8594 Protein denotes 5
T5354 8595-8596 Protein denotes 8
T5355 8909-8914 Protein denotes BMP-6
T5356 8986-8989 Protein denotes Id1 true
T5357 8990-8993 Protein denotes Id4 true
T5358 9083-9095 Positive_regulation denotes upregulation true
T5359 9099-9102 Protein denotes Id1
T5360 9111-9116 Protein denotes BMP-6
T5361 9149-9162 Positive_regulation denotes up-regulation
T5362 9166-9169 Protein denotes Id1
T5363 9235-9247 Positive_regulation denotes upregulation
T5364 9280-9285 Protein denotes BMP-6
T5365 9381-9384 Protein denotes Id2
T5366 9389-9392 Protein denotes Id3 true
T5367 9407-9410 Protein denotes Id4
T5368 9511-9516 Protein denotes BMP-6 true
T5369 9517-9524 Positive_regulation denotes induced
T5370 9525-9537 Positive_regulation denotes upregulation
T5371 9541-9544 Protein denotes Id1
T5372 9575-9587 Positive_regulation denotes upregulation
T5373 9591-9594 Protein denotes Id1
T5374 9616-9624 Positive_regulation denotes increase
T5375 9628-9631 Protein denotes Id1
T5376 9680-9689 Positive_regulation denotes increased
T5377 9711-9716 Protein denotes BMP-6
T5378 9745-9757 Positive_regulation denotes upregulation
T5379 9854-9860 Regulation denotes change
T5380 9879-9882 Protein denotes Id2
T5381 9887-9890 Protein denotes Id3
T5382 9951-9956 Negative_regulation denotes block
T5383 9961-9964 Protein denotes Id1
T5384 10061-10064 Protein denotes Id1
T5385 10115-10122 Regulation denotes effects
T5386 10126-10131 Protein denotes BMP-6
T5387 10158-10161 Protein denotes Id2
T5388 10166-10169 Protein denotes Id3
T6436 10196-10201 Protein denotes BMP-6
T6437 10202-10212 Gene_expression denotes production true
T6438 10238-10243 Protein denotes BMP-6
T6439 10397-10404 Gene_expression denotes produce
T6440 10405-10410 Protein denotes BMP-6
T6441 10471-10478 Gene_expression denotes express
T6442 10479-10484 Protein denotes BMP-6
T6443 10604-10609 Protein denotes BMP-6
T6444 10615-10621 Transcription denotes levels true
T6445 10754-10767 Positive_regulation denotes up-regulation true
T6446 10771-10776 Protein denotes BMP-6
T6447 10926-10931 Protein denotes BMP-6
T6448 10941-10948 Positive_regulation denotes back to
T6449 10949-10957 Negative_regulation denotes baseline
T6450 11044-11051 Positive_regulation denotes induced
T6451 11064-11076 Positive_regulation denotes upregulation
T6452 11080-11085 Protein denotes BMP-6
T6453 11186-11193 Gene_expression denotes express
T6454 11194-11199 Protein denotes BMP-6
T6455 11294-11299 Protein denotes BMP-6
T6456 11413-11418 Protein denotes BMP-6
T6457 11465-11470 Protein denotes BMP-6
T7362 11836-11841 Protein denotes BMP-6
T7363 11862-11866 Protein denotes CD19
T7364 11891-11896 Protein denotes BMP-6
T7365 11919-11923 Protein denotes CD27
T7366 12005-12010 Protein denotes BMP-6
T7367 12011-12018 Positive_regulation denotes induced
T7368 12038-12046 Positive_regulation denotes increase
T7369 12050-12056 Protein denotes Smad-1
T7370 12057-12058 Protein denotes 5
T7371 12059-12060 Protein denotes 8
T7372 12061-12076 Phosphorylation denotes phosphorylation
T7373 12095-12100 Protein denotes BMP-6
T7374 12101-12108 Positive_regulation denotes induced
T7375 12109-12113 Protein denotes Smad
T7376 12114-12129 Phosphorylation denotes phosphorylation
T7377 12134-12142 Positive_regulation denotes followed
T7378 12158-12170 Positive_regulation denotes upregulation
T7379 12174-12177 Protein denotes Id1
T7380 12198-12201 Protein denotes Id1
T7381 12278-12283 Protein denotes BMP-6
T7382 12394-12399 Protein denotes BMP-6
T7383 12420-12431 Negative_regulation denotes neutralized
T7384 12467-12473 Protein denotes Noggin
T7385 12517-12523 Protein denotes Noggin
T7386 12542-12547 Protein denotes BMP-6
T7387 12608-12615 Protein denotes BMP-RIB
T7388 12623-12630 Protein denotes BMP-RII
T7389 12700-12705 Protein denotes BMP-6
T7390 13121-13126 Protein denotes BMP-6
T7391 13188-13193 Protein denotes BMP-2
T7392 13195-13196 Protein denotes 4 true
T7393 13198-13199 Protein denotes 6
T7394 13204-13206 Protein denotes -7
T7395 13370-13375 Protein denotes BMP-4
T7396 13566-13571 Protein denotes BMP-6
T7397 13715-13722 Gene_expression denotes express
T7398 13748-13755 Protein denotes Act-RIA
T7399 13760-13767 Protein denotes BMP-RIB
T7400 13795-13802 Protein denotes BMP-RII
T7401 13807-13815 Protein denotes Act-RIIb
T7402 13836-13843 Binding denotes binding
T7403 13871-13876 Protein denotes BMP-6
T7404 13905-13910 Protein denotes BMP-6
T7405 14149-14164 Phosphorylation denotes phosphorylation
T7406 14197-14202 Protein denotes BMP-2
T7407 14221-14227 Positive_regulation denotes induce
T7408 14228-14238 Positive_regulation denotes activation
T7409 14242-14247 Protein denotes STAT3
T7410 14279-14294 Phosphorylation denotes phosphorylation
T7411 14341-14346 Protein denotes BMP-2
T7412 14412-14427 Phosphorylation denotes phosphorylation
T7413 14436-14441 Protein denotes STAT3
T7414 14446-14451 Protein denotes Smad1
T7415 14452-14453 Protein denotes 5
T7416 14454-14455 Protein denotes 8 true
T7417 14653-14658 Protein denotes BMP-6 true
T7418 14659-14666 Positive_regulation denotes induced
T7419 14667-14674 Regulation denotes changes
T7420 14682-14697 Phosphorylation denotes phosphorylation
T7421 14708-14713 Protein denotes STAT3 true
T7422 14778-14793 Phosphorylation denotes phosphorylation true
T7423 14797-14802 Protein denotes Smad1 true true
T7424 14803-14804 Protein denotes 5
T7425 14805-14806 Protein denotes 8
T7426 14877-14884 Positive_regulation denotes induced
T7427 14885-14900 Phosphorylation denotes phosphorylation
T7428 14904-14909 Protein denotes Smad1
T7429 14910-14911 Protein denotes 5
T7430 14912-14913 Protein denotes 8 true
T7431 15121-15133 Positive_regulation denotes Upregulation true
T7432 15137-15140 Protein denotes Id1 true
T7433 15141-15144 Positive_regulation denotes via
T7434 15145-15150 Protein denotes Smad1
T7435 15151-15152 Protein denotes 5
T7436 15153-15154 Protein denotes 8 true
T7437 15155-15170 Phosphorylation denotes phosphorylation
T7438 15196-15201 Protein denotes BMP-6 true
T7439 15420-15432 Positive_regulation denotes upregulation
T7440 15437-15440 Protein denotes Id1
T7441 15444-15449 Protein denotes BMP-6
T7442 15487-15490 Protein denotes Id2
T7443 15491-15494 Protein denotes Id4
T7444 15577-15589 Positive_regulation denotes upregulation
T7445 15593-15596 Protein denotes Id1 true
T7446 15626-15629 Protein denotes Id2
T7447 15634-15637 Protein denotes Id3 true
T7448 15685-15688 Protein denotes Id1
T7449 15719-15728 Gene_expression denotes expressed
T7450 15806-15816 Gene_expression denotes expression
T7451 15927-15939 Positive_regulation denotes upregulation
T7452 15943-15946 Protein denotes Id1
T7453 16061-16066 Protein denotes TGF-β
T7454 16106-16113 Positive_regulation denotes induces
T7455 16119-16122 Protein denotes Id2
T7456 16127-16130 Protein denotes Id3
T7457 16131-16141 Gene_expression denotes expression
T7458 16159-16162 Protein denotes Id1
T7459 16243-16248 Protein denotes TGF-β
T7460 16290-16293 Protein denotes Id2
T7461 16298-16301 Protein denotes Id3
T7462 16346-16355 Gene_expression denotes expressed
T7463 16409-16412 Protein denotes Id2
T7464 16417-16420 Protein denotes Id3 true
T7465 16458-16467 Gene_expression denotes expressed true
T7466 16473-16476 Protein denotes Id1
T7467 16506-16511 Protein denotes BMP-6
T7468 16520-16526 Positive_regulation denotes induce true
T7469 16539-16546 Regulation denotes changes true
T7470 16562-16572 Gene_expression denotes expression
T7471 16576-16579 Protein denotes Id2
T7472 16584-16587 Protein denotes Id3
T7473 16766-16770 Protein denotes Pax5 true
T7474 16841-16845 Binding denotes bind
T7475 16907-16911 Protein denotes Pax5
T7476 17201-17206 Protein denotes BMP-6
T7477 17235-17247 Positive_regulation denotes upregulation
T7478 17251-17254 Protein denotes Id1 true
T7479 17408-17413 Protein denotes TGF-β true
T7480 17679-17682 Protein denotes Id1 true true
T7481 17850-17855 Protein denotes BMP-6
T7482 18001-18005 Positive_regulation denotes High
T7483 18006-18011 Protein denotes BMP-6
T7484 18012-18027 Transcription denotes mRNA expression
T7485 18135-18143 Regulation denotes targeted
T7486 18144-18154 Gene_expression denotes expression
T7487 18158-18161 Protein denotes Id1
T7488 18302-18307 Protein denotes BMP-6
T7489 18383-18391 Positive_regulation denotes elevated
T7490 18402-18405 Protein denotes Id1
T7491 18410-18413 Protein denotes Id3
T7492 18691-18695 Protein denotes Id-1
T7493 18745-18755 Negative_regulation denotes inhibition
T7494 18759-18763 Protein denotes Id-1
T7495 18769-18779 Gene_expression denotes expression
T7496 18799-18804 Protein denotes BMP-6
T7497 18866-18871 Protein denotes BMP-6
T7498 18872-18881 Gene_expression denotes producing
T7499 19022-19026 Positive_regulation denotes High
T7500 19027-19032 Protein denotes BMP-6
T7501 19033-19048 Transcription denotes mRNA expression
T7502 19124-19134 Gene_expression denotes production
T7503 19138-19143 Protein denotes BMP-6
T7504 19144-19155 Transcription denotes transcripts
T7505 19228-19237 Regulation denotes autocrine
T7506 19238-19243 Protein denotes BMP-6
T7507 19379-19388 Regulation denotes autocrine
T7508 19389-19394 Protein denotes BMP-6
T7509 19434-19444 Gene_expression denotes expression
T7510 19445-19450 Protein denotes BMP-6
T7511 19522-19534 Positive_regulation denotes upregulation
T7512 19549-19554 Protein denotes BMP-6
T7513 19674-19679 Protein denotes BMP-6
T7514 19745-19752 Binding denotes binding
T7515 19846-19853 Gene_expression denotes express
T7516 19854-19859 Protein denotes BMP-6
T7517 19974-19979 Protein denotes BMP-6
T7518 20055-20060 Protein denotes BMP-6
T7519 20061-20071 Gene_expression denotes production
T7520 20137-20147 Gene_expression denotes production
T7521 20151-20156 Protein denotes BMP-6
T7522 20338-20350 Positive_regulation denotes upregulation
T7523 20358-20363 Protein denotes BMP-6
T7524 20447-20452 Protein denotes TGF-β
T7525 20688-20693 Protein denotes BMP-6
T7526 20844-20849 Protein denotes TGF-β
T7527 20876-20882 Protein denotes TGF-β1
T7528 20887-20892 Protein denotes BMP-4
T7529 21017-21029 Positive_regulation denotes upregulation
T7530 21033-21038 Protein denotes BMP-6
T7531 21089-21094 Protein denotes BMP-6
T7532 21133-21136 Protein denotes CD4
T7533 21141-21144 Protein denotes CD8
T7534 21187-21190 Protein denotes CD3
T7535 21200-21204 Protein denotes CD28
T7536 21315-21320 Protein denotes BMP-6
T7537 21481-21486 Protein denotes BMP-6
T7538 21487-21497 Gene_expression denotes production
T7539 21636-21643 Gene_expression denotes express
T7540 21644-21649 Protein denotes BMP-6
T7541 21707-21714 Gene_expression denotes produce
T7542 21715-21720 Protein denotes BMP-6
T7543 21764-21769 Protein denotes BMP-6
T7544 21812-21817 Protein denotes BMP-6
T7545 22038-22043 Protein denotes BMP-6
T7546 22114-22119 Protein denotes BMP-6
T7547 22120-22130 Gene_expression denotes production
T13384 22206-22211 Protein denotes BMP-6
T13693 23147-23151 Protein denotes CD19
T14131 23957-23962 Protein denotes BMP-6
T14132 24006-24013 Protein denotes BMP-RIB
T14133 24014-24019 Protein denotes ALK-6
T14134 24046-24053 Protein denotes BMPR-II
T14135 24098-24104 Protein denotes Noggin
T14136 24311-24322 Protein denotes CD40 ligand
T14137 24324-24329 Protein denotes CD40L
T14361 24499-24506 Protein denotes Act-RIA true
T14362 24508-24515 Protein denotes BMP-RIB true
T14363 24517-24524 Protein denotes BMPR-II
T14364 24526-24534 Protein denotes Act-RIIA
T14365 24539-24547 Protein denotes Act-RIIb
T14366 24615-24620 Protein denotes BMP-6
T14367 24696-24701 Protein denotes BMP-6
T14368 24758-24763 Protein denotes BMP-6
T14369 24789-24794 Protein denotes BMP-6
T14370 24856-24861 Protein denotes BMP-6
T14371 24987-24992 Protein denotes Smad1
T14372 24994-24996 Protein denotes -5
T14373 25003-25004 Protein denotes 8
T14374 25056-25066 Gene_expression denotes Expression
T14375 25077-25080 Protein denotes Id1
T14376 25081-25082 Protein denotes 3
T14377 25427-25434 Protein denotes β-actin
T14378 25512-25516 Protein denotes CD19
T14379 25526-25530 Protein denotes CD19
T14380 25584-25588 Protein denotes CD19
T14381 25641-25645 Protein denotes CD27
T15086 25747-25751 Protein denotes CD19
T15087 25752-25756 Protein denotes CD27
T15088 25761-25765 Protein denotes CD19
T15089 25766-25770 Protein denotes CD27
T15090 25804-25808 Protein denotes CD19
T15091 25826-25830 Protein denotes CD27
T15092 25838-25842 Protein denotes CD19
T15245 26930-26944 Negative_regulation denotes Quantification
T15246 26948-26951 Protein denotes Id1
T15247 26953-26956 Protein denotes Id2
T15248 26961-26964 Protein denotes Id3
T15249 27033-27040 Protein denotes β-actin
T15549 27107-27112 Protein denotes BMP-6 true
T15550 27156-27166 Gene_expression denotes expression true
T15551 27174-27179 Protein denotes BMP-6 true
T15552 27665-27680 Transcription denotes mRNA expression true
T15553 27684-27688 Protein denotes BMP6 true
T15554 27690-27693 Protein denotes Id1 true
T15555 27694-27697 Protein denotes Id4 true
T15556 27702-27706 Protein denotes PGK1 true
T15557 27896-27901 Protein denotes BMP-6 true
T15558 28070-28074 Protein denotes BMP6 true
T15559 28107-28110 Protein denotes Id1 true
T15560 28216-28226 Gene_expression denotes expression true
T15561 28236-28240 Protein denotes PGK1
T15562 28242-28246 Protein denotes PGK1
T15563 28353-28363 Gene_expression denotes Expression
T16228 28494-28498 Protein denotes CD19
R2099 T2583 T2582 themeOf BMP-6,absence
R2100 T2592 T2591 themeOf BMP-6,effects
R10416 T13386 T13385 themeOf production,consecutive
R41 T59 T58 themeOf phosphorylation,induction
R42 T61 T60 themeOf Id1,upregulation
R43 T66 T67 causeOf BMP-6,induced
R44 T66 T65 themeOf BMP-6,express
R45 T68 T67 themeOf phosphorylation,induced
R46 T69 T68 themeOf Smad1,phosphorylation
R47 T70 T68 themeOf 5,phosphorylation
R48 T71 T68 themeOf 8,phosphorylation
R49 T72 T73 themeOf Smad,phosphorylation
R50 T73 T74 causeOf phosphorylation,followed
R51 T75 T74 themeOf upregulation,followed
R52 T76 T75 themeOf Id1,upregulation
R53 T77 T75 themeOf Id1,upregulation
R54 T78 T80 themeOf Id2,expression
R55 T79 T80 themeOf Id3,expression
R56 T80 T81 themeOf expression,affected
R57 T92 T91 themeOf BMP-6,upregulate
R58 T93 T94 causeOf BMP-6,induced
R59 T95 T99 causeOf phosphorylation,followed
R60 T95 T94 themeOf phosphorylation,induced
R61 T96 T95 themeOf Smad1,phosphorylation
R62 T97 T95 themeOf 5,phosphorylation
R63 T98 T95 themeOf 8,phosphorylation
R64 T100 T99 themeOf upregulation,followed
R65 T101 T100 themeOf Id1,upregulation
R3130 T4014 T4013 themeOf BMP-6,express
R3131 T4015 T4019 themeOf Act-RIA,expressed
R3132 T4016 T4019 themeOf BMP-RIB,expressed
R3133 T4017 T4019 themeOf BMP-RII,expressed
R3134 T4018 T4019 themeOf Act-RIIb,expressed
R3135 T4021 T4020 themeOf Act-RIA,expressed
R3136 T4022 T4020 themeOf BMP-RIB,expressed
R3137 T4023 T4020 themeOf BMP-RII,expressed
R3138 T4025 T4024 themeOf Act-RIA,expressed
R3139 T4026 T4024 themeOf BMP-RII,expressed
R3140 T4028 T4027 themeOf BMP-6,bind
R4168 T5345 T5346 causeOf BMP-6,induces
R4169 T5347 T5346 themeOf upregulation,induces
R4170 T5348 T5347 themeOf Id1,upregulation
R4171 T5349 T5350 causeOf BMP-6,induced
R4172 T5351 T5350 themeOf phosphorylation,induced
R4173 T5352 T5351 themeOf Smad 1,phosphorylation
R4174 T5353 T5351 themeOf 5,phosphorylation
R4175 T5354 T5351 themeOf 8,phosphorylation
R4176 T5359 T5358 themeOf Id1,upregulation
R4177 T5360 T5358 causeOf BMP-6,upregulation
R4178 T5362 T5363 themeOf Id1,upregulation
R4179 T5362 T5361 themeOf Id1,up-regulation
R4180 T5364 T5363 causeOf BMP-6,upregulation
R4181 T5364 T5361 causeOf BMP-6,up-regulation
R4182 T5368 T5369 causeOf BMP-6,induced
R4183 T5370 T5369 themeOf upregulation,induced
R4184 T5371 T5370 themeOf Id1,upregulation
R4185 T5373 T5372 themeOf Id1,upregulation
R4186 T5374 T5376 themeOf increase,increased
R4187 T5375 T5378 themeOf Id1,upregulation
R4188 T5375 T5374 themeOf Id1,increase
R4189 T5375 T5376 themeOf Id1,increased
R4190 T5377 T5376 causeOf BMP-6,increased
R4191 T5377 T5374 causeOf BMP-6,increase
R4192 T5378 T5376 causeOf upregulation,increased
R4193 T5380 T5379 themeOf Id2,change
R4194 T5381 T5379 themeOf Id3,change
R4195 T5383 T5382 themeOf Id1,block
R4196 T5386 T5385 causeOf BMP-6,effects
R4197 T5387 T5385 themeOf Id2,effects
R4198 T5388 T5385 themeOf Id3,effects
R5063 T6436 T6437 themeOf BMP-6,production
R5064 T6440 T6439 themeOf BMP-6,produce
R5065 T6442 T6441 themeOf BMP-6,express
R5066 T6443 T6444 themeOf BMP-6,levels
R5067 T6446 T6445 themeOf BMP-6,up-regulation
R5068 T6451 T6450 themeOf upregulation,induced
R5069 T6452 T6451 themeOf BMP-6,upregulation
R5070 T6454 T6453 themeOf BMP-6,express
R5726 T7366 T7367 causeOf BMP-6,induced
R5727 T7368 T7367 themeOf increase,induced
R5728 T7369 T7372 themeOf Smad-1,phosphorylation
R5729 T7370 T7372 themeOf 5,phosphorylation
R5730 T7371 T7372 themeOf 8,phosphorylation
R5731 T7372 T7368 themeOf phosphorylation,increase
R5732 T7373 T7374 causeOf BMP-6,induced
R5733 T7375 T7376 themeOf Smad,phosphorylation
R5734 T7376 T7377 causeOf phosphorylation,followed
R5735 T7376 T7374 themeOf phosphorylation,induced
R5736 T7378 T7377 themeOf upregulation,followed
R5737 T7379 T7378 themeOf Id1,upregulation
R5738 T7380 T7378 themeOf Id1,upregulation
R5739 T7382 T7383 themeOf BMP-6,neutralized
R5740 T7398 T7397 themeOf Act-RIA,express
R5741 T7398 T7402 themeOf Act-RIA,binding
R5742 T7399 T7397 themeOf BMP-RIB,express
R5743 T7399 T7402 themeOf BMP-RIB,binding
R5744 T7400 T7402 themeOf BMP-RII,binding
R5745 T7400 T7397 themeOf BMP-RII,express
R5746 T7401 T7402 themeOf Act-RIIb,binding
R5747 T7401 T7397 themeOf Act-RIIb,express
R5748 T7403 T7402 themeOf BMP-6,binding
R5749 T7406 T7407 causeOf BMP-2,induce
R5750 T7408 T7407 themeOf activation,induce
R5751 T7409 T7408 themeOf STAT3,activation
R5752 T7413 T7412 themeOf STAT3,phosphorylation
R5753 T7414 T7412 themeOf Smad1,phosphorylation
R5754 T7415 T7412 themeOf 5,phosphorylation
R5755 T7416 T7412 themeOf 8,phosphorylation
R5756 T7417 T7419 causeOf BMP-6,changes
R5757 T7417 T7418 causeOf BMP-6,induced
R5758 T7419 T7418 themeOf changes,induced
R5759 T7420 T7419 themeOf phosphorylation,changes
R5760 T7421 T7420 themeOf STAT3,phosphorylation
R5761 T7423 T7422 themeOf Smad1,phosphorylation
R5762 T7424 T7422 themeOf 5,phosphorylation
R5763 T7425 T7422 themeOf 8,phosphorylation
R5764 T7427 T7426 themeOf phosphorylation,induced
R5765 T7428 T7427 themeOf Smad1,phosphorylation
R5766 T7429 T7427 themeOf 5,phosphorylation
R5767 T7430 T7427 themeOf 8,phosphorylation
R5769 T7432 T7431 themeOf Id1,Upregulation
R5770 T7434 T7437 themeOf Smad1,phosphorylation
R5796 T7483 T7484 themeOf BMP-6,mRNA expression
R5797 T7484 T7482 themeOf mRNA expression,High
R5798 T7486 T7485 themeOf expression,targeted
R5799 T7487 T7486 themeOf Id1,expression
R5800 T7488 T7489 causeOf BMP-6,elevated
R5801 T7494 T7495 themeOf Id-1,expression
R5802 T7495 T7493 themeOf expression,inhibition
R5803 T7497 T7498 themeOf BMP-6,producing
R5804 T7500 T7501 themeOf BMP-6,mRNA expression
R5805 T7501 T7499 themeOf mRNA expression,High
R5806 T7503 T7502 themeOf BMP-6,production
R5807 T7503 T7504 themeOf BMP-6,transcripts
R5808 T7506 T7505 causeOf BMP-6,autocrine
R5809 T7508 T7507 causeOf BMP-6,autocrine
R5810 T7510 T7509 themeOf BMP-6,expression
R5811 T7512 T7511 themeOf BMP-6,upregulation
R5812 T7513 T7514 themeOf BMP-6,binding
R5813 T7516 T7515 themeOf BMP-6,express
R5814 T7518 T7519 themeOf BMP-6,production
R5815 T7521 T7520 themeOf BMP-6,production
R5816 T7523 T7522 themeOf BMP-6,upregulation
R5817 T7530 T7529 themeOf BMP-6,upregulation
R5818 T7537 T7538 themeOf BMP-6,production
R5819 T7540 T7539 themeOf BMP-6,express
R5820 T7542 T7541 themeOf BMP-6,produce
R5821 T7546 T7547 themeOf BMP-6,production
R10417 T13387 T13386 themeOf Id1,production
R11159 T14375 T14374 themeOf Id1,Expression
R11749 T15246 T15245 themeOf Id1,Quantification
R11750 T15247 T15245 themeOf Id2,Quantification
R11751 T15248 T15245 themeOf Id3,Quantification
R11973 T15551 T15550 themeOf BMP-6,expression
R11974 T15553 T15552 themeOf BMP6,mRNA expression
R11975 T15554 T15552 themeOf Id1,mRNA expression
R11976 T15555 T15552 themeOf Id4,mRNA expression
R11977 T15556 T15552 themeOf PGK1,mRNA expression
R11978 T15561 T15560 themeOf PGK1,expression
R5768 T7431 T7433 themeOf Upregulation,via
R5771 T7435 T7437 themeOf 5,phosphorylation
R5772 T7436 T7437 themeOf 8,phosphorylation
R5773 T7437 T7431 causeOf phosphorylation,Upregulation
R5774 T7440 T7439 themeOf Id1,upregulation
R5775 T7441 T7439 causeOf BMP-6,upregulation
R5776 T7445 T7444 themeOf Id1,upregulation
R5777 T7448 T7449 themeOf Id1,expressed
R5778 T7448 T7450 themeOf Id1,expression
R5779 T7452 T7451 themeOf Id1,upregulation
R5780 T7455 T7457 themeOf Id2,expression
R5781 T7456 T7457 themeOf Id3,expression
R5782 T7457 T7454 themeOf expression,induces
R5783 T7458 T7454 themeOf Id1,induces
R5784 T7460 T7462 themeOf Id2,expressed
R5785 T7461 T7462 themeOf Id3,expressed
R5786 T7463 T7465 themeOf Id2,expressed
R5787 T7464 T7465 themeOf Id3,expressed
R5788 T7466 T7465 themeOf Id1,expressed
R5789 T7467 T7468 causeOf BMP-6,induce
R5790 T7467 T7469 causeOf BMP-6,changes
R5791 T7470 T7469 themeOf expression,changes
R5792 T7471 T7470 themeOf Id2,expression
R5793 T7472 T7470 themeOf Id3,expression
R5794 T7473 T7474 themeOf Pax5,bind
R5795 T7478 T7477 themeOf Id1,upregulation

tees-test

Id Subject Object Predicate Lexical cue
T1 0-5 D055418 denotes BMP-6
T2 0-5 D055418 denotes BMP-6
T3 0-5 Q04906 denotes BMP-6
T4 0-5 PR:000000167 denotes BMP-6
T5 0-5 P20722 denotes BMP-6
T6 0-5 PR:Q04906 denotes BMP-6
T7 0-5 P22004 denotes BMP-6
T8 0-5 PR:P22004 denotes BMP-6
T9 0-5 PR:P20722 denotes BMP-6
T10 32-37 D006801 denotes human
T11 65-80 GO:0016310 denotes phosphorylation
T12 101-104 PR:P41134 denotes Id1
T13 101-104 PR:P20067 denotes Id1
T14 101-104 PR:P41135 denotes Id1
T15 101-104 PR:000000039 denotes Id1
T16 127-154 D019485 denotes Bone morphogenetic proteins
T17 127-154 D019485 denotes Bone morphogenetic proteins
T18 176-181 D016212 denotes TGF-β
T19 176-181 D016212 denotes TGF-β
T20 176-193 PR:000000008 denotes TGF-β superfamily
T21 211-219 CHEBI:36080 denotes proteins
T22 293-298 D055418 denotes BMP-6
T23 293-298 D055418 denotes BMP-6
T24 293-298 Q04906 denotes BMP-6
T25 293-298 PR:000000167 denotes BMP-6
T26 293-298 P20722 denotes BMP-6
T27 293-298 PR:Q04906 denotes BMP-6
T28 293-298 P22004 denotes BMP-6
T29 293-298 PR:P22004 denotes BMP-6
T30 293-298 PR:P20722 denotes BMP-6
T31 306-319 D007154 denotes immune system
T32 306-319 D007154 denotes immune system
T33 306-319 UBERON:0002405 denotes immune system
T34 440-445 D055418 denotes BMP-6
T35 440-445 D055418 denotes BMP-6
T36 440-445 Q04906 denotes BMP-6
T37 440-445 PR:000000167 denotes BMP-6
T38 440-445 P20722 denotes BMP-6
T39 440-445 PR:Q04906 denotes BMP-6
T40 440-445 P22004 denotes BMP-6
T41 440-445 PR:P22004 denotes BMP-6
T42 440-445 PR:P20722 denotes BMP-6
T43 456-461 D006801 denotes human
T44 531-534 CHEBI:60815 denotes BMP
T45 531-534 PR:000000034 denotes BMP
T46 531-534 P35855 denotes BMP
T47 568-573 D055418 denotes BMP-6
T48 568-573 D055418 denotes BMP-6
T49 568-573 Q04906 denotes BMP-6
T50 568-573 PR:000000167 denotes BMP-6
T51 568-573 P20722 denotes BMP-6
T52 568-573 PR:Q04906 denotes BMP-6
T53 568-573 P22004 denotes BMP-6
T54 568-573 PR:P22004 denotes BMP-6
T55 568-573 PR:P20722 denotes BMP-6
T56 590-605 GO:0016310 denotes phosphorylation
T57 609-614 PR:Q9I8V2 denotes Smad1
T58 609-614 PR:P97588 denotes Smad1
T59 609-614 Q15797 denotes Smad1
T60 609-614 PR:000000363 denotes Smad1
T61 609-614 PR:P70340 denotes Smad1
T62 609-614 P70340 denotes Smad1
T63 609-614 Q9I962 denotes Smad1
T64 609-614 PR:Q15797 denotes Smad1
T65 609-614 P97588 denotes Smad1
T66 609-614 Q9I8V2 denotes Smad1
T67 609-614 Q1JQA2 denotes Smad1
T68 638-653 GO:0016310 denotes phosphorylation
T69 686-689 PR:P41134 denotes Id1
T70 686-689 PR:P20067 denotes Id1
T71 686-689 PR:P41135 denotes Id1
T72 686-689 PR:000000039 denotes Id1
T73 690-694 D012333 denotes mRNA
T74 690-694 CHEBI:33699 denotes mRNA
T75 690-694 SO:0000234 denotes mRNA
T76 699-702 PR:P41134 denotes Id1
T77 699-702 PR:P20067 denotes Id1
T78 699-702 PR:P41135 denotes Id1
T79 699-702 PR:000000039 denotes Id1
T80 703-710 PR:000000001 denotes protein
T81 703-710 CHEBI:36080 denotes protein
T82 703-710 CHEBI:11122 denotes protein
T83 703-710 SO:0000104 denotes protein
T84 703-710 GO:0003675 denotes protein
T85 720-723 PR:000000040 denotes Id2
T86 720-723 PR:P41137 denotes Id2
T87 720-723 PR:Q02363 denotes Id2
T88 720-723 PR:P41136 denotes Id2
T89 720-723 C039556 denotes Id2
T90 720-723 C039556 denotes Id2
T91 728-731 PR:P41133 denotes Id3
T92 728-731 PR:P41138 denotes Id3
T93 728-731 PR:Q02535 denotes Id3
T94 728-731 PR:000000041 denotes Id3
T95 788-793 D055418 denotes BMP-6
T96 788-793 D055418 denotes BMP-6
T97 788-793 Q04906 denotes BMP-6
T98 788-793 PR:000000167 denotes BMP-6
T99 788-793 P20722 denotes BMP-6
T100 788-793 PR:Q04906 denotes BMP-6
T101 788-793 P22004 denotes BMP-6
T102 788-793 PR:P22004 denotes BMP-6
T103 788-793 PR:P20722 denotes BMP-6
T104 841-845 PR:P25918 denotes CD19
T105 841-845 PR:P15391 denotes CD19
T106 841-845 PR:000001002 denotes CD19
T107 846-850 PR:P41272 denotes CD27
T108 846-850 PR:000001963 denotes CD27
T109 846-850 PR:P26842 denotes CD27
T110 857-863 GO:0007613 denotes memory
T111 873-877 PR:P25918 denotes CD19
T112 873-877 PR:P15391 denotes CD19
T113 873-877 PR:000001002 denotes CD19
T114 878-882 PR:P41272 denotes CD27
T115 878-882 PR:000001963 denotes CD27
T116 878-882 PR:P26842 denotes CD27
T117 901-909 C044203 denotes anti-IgM
T118 942-950 C044203 denotes anti-IgM
T119 955-960 D023201 denotes CD40L
T120 955-960 D023201 denotes CD40L
T121 955-960 PR:P27548 denotes CD40L
T122 955-960 PR:Q9I8D8 denotes CD40L
T123 955-960 PR:000001950 denotes CD40L
T124 955-960 PR:P29965 denotes CD40L
T125 955-960 PR:Q9Z2V2 denotes CD40L
T126 955-960 P27548 denotes CD40L
T127 955-960 Q95MQ5 denotes CD40L
T128 955-960 Q9BDM3 denotes CD40L
T129 955-960 P63305 denotes CD40L
T130 955-960 Q9BDM7 denotes CD40L
T131 955-960 O97626 denotes CD40L
T132 955-960 O97605 denotes CD40L
T133 955-960 Q9Z2V2 denotes CD40L
T134 955-960 P63304 denotes CD40L
T135 955-960 Q9BDN3 denotes CD40L
T136 955-960 Q9I8D8 denotes CD40L
T137 955-960 P29965 denotes CD40L
T138 955-960 P51749 denotes CD40L
T139 976-981 D055418 denotes BMP-6
T140 976-981 D055418 denotes BMP-6
T141 976-981 Q04906 denotes BMP-6
T142 976-981 PR:000000167 denotes BMP-6
T143 976-981 P20722 denotes BMP-6
T144 976-981 PR:Q04906 denotes BMP-6
T145 976-981 P22004 denotes BMP-6
T146 976-981 PR:P22004 denotes BMP-6
T147 976-981 PR:P20722 denotes BMP-6
T148 990-1000 GO:0008219 denotes cell death
T149 1014-1020 GO:0007613 denotes memory
T150 1075-1080 D055418 denotes BMP-6
T151 1075-1080 D055418 denotes BMP-6
T152 1075-1080 Q04906 denotes BMP-6
T153 1075-1080 PR:000000167 denotes BMP-6
T154 1075-1080 P20722 denotes BMP-6
T155 1075-1080 PR:Q04906 denotes BMP-6
T156 1075-1080 P22004 denotes BMP-6
T157 1075-1080 PR:P22004 denotes BMP-6
T158 1075-1080 PR:P20722 denotes BMP-6
T159 1134-1144 CHEBI:48706 denotes antagonist
T160 1146-1152 P97466 denotes noggin
T161 1146-1152 Q13253 denotes noggin
T162 1146-1152 Q9YHT8 denotes noggin
T163 1146-1152 PR:000000021 denotes noggin
T164 1146-1152 O93525 denotes noggin
T165 1146-1152 P49011 denotes noggin
T166 1146-1152 Q62809 denotes noggin
T167 1207-1212 D055418 denotes BMP-6
T168 1207-1212 D055418 denotes BMP-6
T169 1207-1212 Q04906 denotes BMP-6
T170 1207-1212 PR:000000167 denotes BMP-6
T171 1207-1212 P20722 denotes BMP-6
T172 1207-1212 PR:Q04906 denotes BMP-6
T173 1207-1212 P22004 denotes BMP-6
T174 1207-1212 PR:P22004 denotes BMP-6
T175 1207-1212 PR:P20722 denotes BMP-6
T176 1213-1217 D012333 denotes mRNA
T177 1213-1217 CHEBI:33699 denotes mRNA
T178 1213-1217 SO:0000234 denotes mRNA
T179 1240-1248 C044203 denotes anti-IgM
T180 1272-1277 D006801 denotes human
T181 1287-1292 D055418 denotes BMP-6
T182 1287-1292 D055418 denotes BMP-6
T183 1287-1292 Q04906 denotes BMP-6
T184 1287-1292 PR:000000167 denotes BMP-6
T185 1287-1292 P20722 denotes BMP-6
T186 1287-1292 PR:Q04906 denotes BMP-6
T187 1287-1292 P22004 denotes BMP-6
T188 1287-1292 PR:P22004 denotes BMP-6
T189 1287-1292 PR:P20722 denotes BMP-6
T190 1303-1314 GO:0016049 denotes cell growth
T191 1336-1351 GO:0016310 denotes phosphorylation
T192 1355-1360 PR:Q9I8V2 denotes Smad1
T193 1355-1360 PR:P97588 denotes Smad1
T194 1355-1360 Q15797 denotes Smad1
T195 1355-1360 PR:000000363 denotes Smad1
T196 1355-1360 PR:P70340 denotes Smad1
T197 1355-1360 P70340 denotes Smad1
T198 1355-1360 Q9I962 denotes Smad1
T199 1355-1360 PR:Q15797 denotes Smad1
T200 1355-1360 P97588 denotes Smad1
T201 1355-1360 Q9I8V2 denotes Smad1
T202 1355-1360 Q1JQA2 denotes Smad1
T203 1396-1399 PR:P41134 denotes Id1
T204 1396-1399 PR:P20067 denotes Id1
T205 1396-1399 PR:P41135 denotes Id1
T206 1396-1399 PR:000000039 denotes Id1
T207 1429-1457 D016212 denotes transforming growth factor β
T208 1429-1457 D016212 denotes transforming growth factor β
T209 1429-1457 PR:000000046 denotes transforming growth factor β
T210 1429-1457 GO:0005160 denotes transforming growth factor β
T211 1459-1464 D016212 denotes TGF-β
T212 1459-1464 D016212 denotes TGF-β
T213 1459-1477 PR:000000008 denotes TGF-β) superfamily
T214 1521-1534 UBERON:2000098 denotes proliferation
T215 1567-1576 GO:0097194 denotes apoptosis
T216 1567-1576 GO:0006915 denotes apoptosis
T217 1588-1597 D016207 denotes cytokines
T218 1588-1597 D016207 denotes cytokines
T219 1635-1640 D016212 denotes TGF-β
T220 1635-1640 D016212 denotes TGF-β
T221 1635-1640 PR:000000046 denotes TGF-β
T222 1646-1654 D028341 denotes activins
T223 1655-1663 D007265 denotes inhibins
T224 1655-1663 D007265 denotes inhibins
T225 1673-1677 UBERON:0001474 denotes bone
T226 1673-1677 UBERON:0002481 denotes bone
T227 1673-1700 D019485 denotes bone morphogenetic proteins
T228 1673-1700 D019485 denotes bone morphogenetic proteins
T229 1802-1810 CHEBI:36080 denotes proteins
T230 1868-1877 UBERON:0002418 denotes cartilage
T231 1868-1877 UBERON:0007844 denotes cartilage
T232 1882-1886 UBERON:0001474 denotes bone
T233 1882-1886 UBERON:0002481 denotes bone
T234 1882-1896 GO:0001503 denotes bone formation
T235 1965-1973 CHEBI:36080 denotes proteins
T236 1981-1994 GO:0009792 denotes embryogenesis
T237 1981-1994 GO:0009793 denotes embryogenesis
T238 1981-1994 GO:0009790 denotes embryogenesis
T239 1981-1994 UBERON:0000068 denotes embryogenesis
T240 2023-2028 UBERON:0007023 denotes adult
T241 2042-2047 PR:000000046 denotes TGF-β
T242 2042-2047 D016212 denotes TGF-β
T243 2042-2047 D016212 denotes TGF-β
T244 2242-2255 D007154 denotes immune system
T245 2242-2255 D007154 denotes immune system
T246 2242-2255 UBERON:0002405 denotes immune system
T247 2307-2310 CHEBI:60815 denotes BMP
T248 2307-2313 PR:P49001 denotes BMP- 2
T249 2307-2313 PR:P21274 denotes BMP- 2
T250 2307-2313 Q804S2 denotes BMP- 2
T251 2307-2313 P49001 denotes BMP- 2
T252 2307-2313 P12643 denotes BMP- 2
T253 2307-2313 P21274 denotes BMP- 2
T254 2307-2313 Q90751 denotes BMP- 2
T255 2307-2313 O46564 denotes BMP- 2
T256 2307-2313 PR:P12643 denotes BMP- 2
T257 2307-2313 PR:000000164 denotes BMP- 2
T258 2307-2313 O19006 denotes BMP- 2
T259 2410-2416 CL:0000084 denotes T cell
T260 2410-2428 GO:0030217 denotes T cell development
T261 2436-2441 D055418 denotes BMP-6
T262 2436-2441 D055418 denotes BMP-6
T263 2436-2441 Q04906 denotes BMP-6
T264 2436-2441 PR:000000167 denotes BMP-6
T265 2436-2441 P20722 denotes BMP-6
T266 2436-2441 PR:Q04906 denotes BMP-6
T267 2436-2441 P22004 denotes BMP-6
T268 2436-2441 PR:P22004 denotes BMP-6
T269 2436-2441 PR:P20722 denotes BMP-6
T270 2525-2530 D006801 denotes human
T271 2570-2573 CHEBI:60815 denotes BMP
T272 2570-2575 PR:P49001 denotes BMP-2
T273 2570-2575 PR:P21274 denotes BMP-2
T274 2570-2575 Q804S2 denotes BMP-2
T275 2570-2575 P49001 denotes BMP-2
T276 2570-2575 P12643 denotes BMP-2
T277 2570-2575 P21274 denotes BMP-2
T278 2570-2575 Q90751 denotes BMP-2
T279 2570-2575 O46564 denotes BMP-2
T280 2570-2575 PR:P12643 denotes BMP-2
T281 2570-2575 PR:000000164 denotes BMP-2
T282 2570-2575 O19006 denotes BMP-2
T283 2644-2660 D009101 denotes multiple myeloma
T284 2644-2660 D009101 denotes multiple myeloma
T285 2691-2695 SO:0000704 denotes gene
T286 2691-2706 GO:0010467 denotes gene expression
T287 2718-2723 D055418 denotes BMP-6
T288 2718-2723 D055418 denotes BMP-6
T289 2718-2723 Q04906 denotes BMP-6
T290 2718-2723 PR:000000167 denotes BMP-6
T291 2718-2723 P20722 denotes BMP-6
T292 2718-2723 PR:Q04906 denotes BMP-6
T293 2718-2723 P22004 denotes BMP-6
T294 2718-2723 PR:P22004 denotes BMP-6
T295 2718-2723 PR:P20722 denotes BMP-6
T296 2781-2785 SO:0000704 denotes gene
T297 2786-2795 SO:0001978 denotes signature
T298 2857-2863 CL:0000236 denotes B cell
T299 2857-2873 D016393 denotes B cell lymphomas
T300 2857-2873 D016393 denotes B cell lymphomas
T301 2888-2893 D055418 denotes BMP-6
T302 2888-2893 D055418 denotes BMP-6
T303 2888-2893 Q04906 denotes BMP-6
T304 2888-2893 PR:000000167 denotes BMP-6
T305 2888-2893 P20722 denotes BMP-6
T306 2888-2893 PR:Q04906 denotes BMP-6
T307 2888-2893 P22004 denotes BMP-6
T308 2888-2893 PR:P22004 denotes BMP-6
T309 2888-2893 PR:P20722 denotes BMP-6
T310 2910-2913 CHEBI:60815 denotes BMP
T311 2910-2913 PR:000000034 denotes BMP
T312 2910-2913 P35855 denotes BMP
T313 2973-2976 CHEBI:60815 denotes BMP
T314 2973-2976 PR:000000034 denotes BMP
T315 2973-2976 P35855 denotes BMP
T316 2985-2992 D028341 denotes activin
T317 2985-2992 GO:0016915 denotes activin
T318 2985-2992 GO:0005160 denotes activin
T319 3006-3009 PR:P97793 denotes ALK
T320 3006-3009 PR:000001282 denotes ALK
T321 3006-3009 PR:Q9UM73 denotes ALK
T322 3024-3030 9671 denotes serine
T323 3024-3030 SO:0001444 denotes serine
T324 3024-3047 D017346 denotes serine-threonine kinase
T325 3031-3040 10524 denotes threonine
T326 3031-3040 SO:0001445 denotes threonine
T327 3093-3099 SO:0000725 denotes signal
T328 3093-3099 SO:0000418 denotes signal
T329 3100-3110 SO:0001633 denotes downstream
T330 3130-3143 D051785 denotes Smad proteins
T331 3145-3150 D055418 denotes BMP-6
T332 3145-3150 D055418 denotes BMP-6
T333 3145-3150 Q04906 denotes BMP-6
T334 3145-3150 PR:000000167 denotes BMP-6
T335 3145-3150 P20722 denotes BMP-6
T336 3145-3150 PR:Q04906 denotes BMP-6
T337 3145-3150 P22004 denotes BMP-6
T338 3145-3150 PR:P22004 denotes BMP-6
T339 3145-3150 PR:P20722 denotes BMP-6
T340 3155-3161 SO:0000725 denotes signal
T341 3155-3161 SO:0000418 denotes signal
T342 3216-3219 CHEBI:60815 denotes BMP
T343 3216-3219 PR:000000034 denotes BMP
T344 3216-3219 P35855 denotes BMP
T345 3229-3232 CHEBI:60815 denotes BMP
T346 3229-3232 PR:000000034 denotes BMP
T347 3229-3232 P35855 denotes BMP
T348 3233-3236 CHEBI:33942 denotes RIB
T349 3233-3236 UBERON:0002228 denotes RIB
T350 3253-3266 D052004 denotes receptors BMP
T351 3263-3266 PR:000000034 denotes BMP
T352 3263-3266 P35855 denotes BMP
T353 3313-3328 GO:0016310 denotes phosphorylation
T354 3352-3358 PR:Q9I8V2 denotes Smad-1
T355 3352-3358 PR:P97588 denotes Smad-1
T356 3352-3358 Q15797 denotes Smad-1
T357 3352-3358 PR:000000363 denotes Smad-1
T358 3352-3358 PR:P70340 denotes Smad-1
T359 3352-3358 P70340 denotes Smad-1
T360 3352-3358 Q9I962 denotes Smad-1
T361 3352-3358 PR:Q15797 denotes Smad-1
T362 3352-3358 P97588 denotes Smad-1
T363 3352-3358 Q9I8V2 denotes Smad-1
T364 3352-3358 Q1JQA2 denotes Smad-1
T365 3360-3366 PR:P97454 denotes Smad-5
T366 3360-3366 PR:Q9R1V3 denotes Smad-5
T367 3360-3366 PR:Q9W7E7 denotes Smad-5
T368 3360-3366 Q5R6H7 denotes Smad-5
T369 3360-3366 Q56I99 denotes Smad-5
T370 3360-3366 Q9W7E7 denotes Smad-5
T371 3360-3366 PR:Q56I99 denotes Smad-5
T372 3360-3366 Q99717 denotes Smad-5
T373 3360-3366 P97454 denotes Smad-5
T374 3360-3366 Q9R1V3 denotes Smad-5
T375 3360-3366 PR:Q99717 denotes Smad-5
T376 3360-3366 PR:000000372 denotes Smad-5
T377 3372-3378 Q9JIW5 denotes Smad-8
T378 3372-3378 PR:O54835 denotes Smad-8
T379 3372-3378 PR:000000375 denotes Smad-8
T380 3372-3378 PR:Q9JIW5 denotes Smad-8
T381 3372-3378 O54835 denotes Smad-8
T382 3372-3378 PR:O15198 denotes Smad-8
T383 3432-3437 Q13485 denotes Smad4
T384 3432-3437 PR:P97471 denotes Smad4
T385 3432-3437 P97471 denotes Smad4
T386 3432-3437 O70437 denotes Smad4
T387 3432-3437 Q1HE26 denotes Smad4
T388 3432-3437 PR:O70437 denotes Smad4
T389 3432-3437 Q9GKQ9 denotes Smad4
T390 3432-3437 PR:000000128 denotes Smad4
T391 3432-3437 PR:Q13485 denotes Smad4
T392 3469-3476 CHEBI:33252 denotes nucleus
T393 3469-3476 UBERON:0000125 denotes nucleus
T394 3469-3476 GO:0005634 denotes nucleus
T395 3494-3498 SO:0000704 denotes gene
T396 3499-3509 GO:0065007 denotes regulation
T397 3545-3550 D055418 denotes BMP-6
T398 3545-3550 D055418 denotes BMP-6
T399 3545-3550 Q04906 denotes BMP-6
T400 3545-3550 PR:000000167 denotes BMP-6
T401 3545-3550 P20722 denotes BMP-6
T402 3545-3550 PR:Q04906 denotes BMP-6
T403 3545-3550 P22004 denotes BMP-6
T404 3545-3550 PR:P22004 denotes BMP-6
T405 3545-3550 PR:P20722 denotes BMP-6
T406 3554-3560 CL:0000236 denotes B-cell
T407 3561-3573 D009369 denotes malignancies
T408 3561-3573 D009369 denotes malignancies
T409 3661-3666 D006801 denotes human
T410 3702-3707 D055418 denotes BMP-6
T411 3702-3707 D055418 denotes BMP-6
T412 3702-3707 Q04906 denotes BMP-6
T413 3702-3707 PR:000000167 denotes BMP-6
T414 3702-3707 P20722 denotes BMP-6
T415 3702-3707 PR:Q04906 denotes BMP-6
T416 3702-3707 P22004 denotes BMP-6
T417 3702-3707 PR:P22004 denotes BMP-6
T418 3702-3707 PR:P20722 denotes BMP-6
T419 3711-3724 UBERON:2000098 denotes proliferation
T420 3729-3738 GO:0097194 denotes apoptosis
T421 3729-3738 GO:0006915 denotes apoptosis
T422 3805-3808 PR:000000034 denotes BMP
T423 3805-3808 P35855 denotes BMP
T424 3805-3818 D052004 denotes BMP receptors
T425 3823-3828 D055418 denotes BMP-6
T426 3823-3828 D055418 denotes BMP-6
T427 3823-3828 Q04906 denotes BMP-6
T428 3823-3828 PR:000000167 denotes BMP-6
T429 3823-3828 P20722 denotes BMP-6
T430 3823-3828 PR:Q04906 denotes BMP-6
T431 3823-3828 P22004 denotes BMP-6
T432 3823-3828 PR:P22004 denotes BMP-6
T433 3823-3828 PR:P20722 denotes BMP-6
T434 3860-3878 GO:0007165 denotes signalling pathway
T435 3871-3878 CHEBI:34922 denotes pathway
T436 3895-3905 GO:0065007 denotes regulation
T437 3926-3929 PR:P41134 denotes Id1
T438 3926-3929 PR:P20067 denotes Id1
T439 3926-3929 PR:P41135 denotes Id1
T440 3926-3929 PR:000000039 denotes Id1
T441 3930-3933 PR:P47928 denotes Id4
T442 3930-3933 PR:P41139 denotes Id4
T443 3930-3933 PR:000000042 denotes Id4
T444 4022-4027 D055418 denotes BMP-6
T445 4022-4027 D055418 denotes BMP-6
T446 4022-4027 Q04906 denotes BMP-6
T447 4022-4027 PR:000000167 denotes BMP-6
T448 4022-4027 P20722 denotes BMP-6
T449 4022-4027 PR:Q04906 denotes BMP-6
T450 4022-4027 P22004 denotes BMP-6
T451 4022-4027 PR:P22004 denotes BMP-6
T452 4022-4027 PR:P20722 denotes BMP-6
T453 4039-4044 D055418 denotes BMP-6
T454 4039-4044 D055418 denotes BMP-6
T455 4039-4044 Q04906 denotes BMP-6
T456 4039-4044 PR:000000167 denotes BMP-6
T457 4039-4044 P20722 denotes BMP-6
T458 4039-4044 PR:Q04906 denotes BMP-6
T459 4039-4044 P22004 denotes BMP-6
T460 4039-4044 PR:P22004 denotes BMP-6
T461 4039-4044 PR:P20722 denotes BMP-6
T462 4054-4062 C044203 denotes anti-IgM
T463 4071-4084 UBERON:2000098 denotes proliferation
T464 4088-4093 D006801 denotes human
T465 4117-4122 D055418 denotes BMP-6
T466 4117-4122 D055418 denotes BMP-6
T467 4117-4122 Q04906 denotes BMP-6
T468 4117-4122 PR:000000167 denotes BMP-6
T469 4117-4122 P20722 denotes BMP-6
T470 4117-4122 PR:Q04906 denotes BMP-6
T471 4117-4122 P22004 denotes BMP-6
T472 4117-4122 PR:P22004 denotes BMP-6
T473 4117-4122 PR:P20722 denotes BMP-6
T474 4210-4215 D055418 denotes BMP-6
T475 4210-4215 D055418 denotes BMP-6
T476 4210-4215 Q04906 denotes BMP-6
T477 4210-4215 PR:000000167 denotes BMP-6
T478 4210-4215 P20722 denotes BMP-6
T479 4210-4215 PR:Q04906 denotes BMP-6
T480 4210-4215 P22004 denotes BMP-6
T481 4210-4215 PR:P22004 denotes BMP-6
T482 4210-4215 PR:P20722 denotes BMP-6
T483 4226-4231 D006801 denotes human
T484 4292-4297 UBERON:0001977 denotes serum
T485 4354-4357 CHEBI:60815 denotes BMP
T486 4354-4357 PR:000000034 denotes BMP
T487 4354-4357 P35855 denotes BMP
T488 4358-4368 GO:0023052 denotes signalling
T489 4416-4421 D055418 denotes BMP-6
T490 4416-4421 D055418 denotes BMP-6
T491 4416-4421 Q04906 denotes BMP-6
T492 4416-4421 PR:000000167 denotes BMP-6
T493 4416-4421 P20722 denotes BMP-6
T494 4416-4421 PR:Q04906 denotes BMP-6
T495 4416-4421 P22004 denotes BMP-6
T496 4416-4421 PR:P22004 denotes BMP-6
T497 4416-4421 PR:P20722 denotes BMP-6
T498 4425-4438 UBERON:2000098 denotes proliferation
T499 4493-4501 C044203 denotes anti-IgM
T500 4509-4514 D023201 denotes CD40L
T501 4509-4514 D023201 denotes CD40L
T502 4509-4514 PR:P27548 denotes CD40L
T503 4509-4514 PR:Q9I8D8 denotes CD40L
T504 4509-4514 PR:000001950 denotes CD40L
T505 4509-4514 PR:P29965 denotes CD40L
T506 4509-4514 PR:Q9Z2V2 denotes CD40L
T507 4509-4514 P27548 denotes CD40L
T508 4509-4514 Q95MQ5 denotes CD40L
T509 4509-4514 Q9BDM3 denotes CD40L
T510 4509-4514 P63305 denotes CD40L
T511 4509-4514 Q9BDM7 denotes CD40L
T512 4509-4514 O97626 denotes CD40L
T513 4509-4514 O97605 denotes CD40L
T514 4509-4514 Q9Z2V2 denotes CD40L
T515 4509-4514 P63304 denotes CD40L
T516 4509-4514 Q9BDN3 denotes CD40L
T517 4509-4514 Q9I8D8 denotes CD40L
T518 4509-4514 P29965 denotes CD40L
T519 4509-4514 P51749 denotes CD40L
T520 4545-4550 D055418 denotes BMP-6
T521 4545-4550 D055418 denotes BMP-6
T522 4545-4550 Q04906 denotes BMP-6
T523 4545-4550 PR:000000167 denotes BMP-6
T524 4545-4550 P20722 denotes BMP-6
T525 4545-4550 PR:Q04906 denotes BMP-6
T526 4545-4550 P22004 denotes BMP-6
T527 4545-4550 PR:P22004 denotes BMP-6
T528 4545-4550 PR:P20722 denotes BMP-6
T529 4581-4586 D055418 denotes BMP-6
T530 4581-4586 D055418 denotes BMP-6
T531 4581-4586 Q04906 denotes BMP-6
T532 4581-4586 PR:000000167 denotes BMP-6
T533 4581-4586 P20722 denotes BMP-6
T534 4581-4586 PR:Q04906 denotes BMP-6
T535 4581-4586 P22004 denotes BMP-6
T536 4581-4586 PR:P22004 denotes BMP-6
T537 4581-4586 PR:P20722 denotes BMP-6
T538 4605-4614 MOP:0000569 denotes reduction
T539 4618-4626 C044203 denotes anti-IgM
T540 4636-4639 CHEBI:16991 denotes DNA
T541 4636-4639 D004247 denotes DNA
T542 4636-4639 GO:0005574 denotes DNA
T543 4636-4639 SO:0000352 denotes DNA
T544 4636-4649 GO:0071897 denotes DNA synthesis
T545 4737-4745 C044203 denotes anti-IgM
T546 4750-4755 D023201 denotes CD40L
T547 4750-4755 D023201 denotes CD40L
T548 4750-4755 PR:P27548 denotes CD40L
T549 4750-4755 PR:Q9I8D8 denotes CD40L
T550 4750-4755 PR:000001950 denotes CD40L
T551 4750-4755 PR:P29965 denotes CD40L
T552 4750-4755 PR:Q9Z2V2 denotes CD40L
T553 4750-4755 P27548 denotes CD40L
T554 4750-4755 Q95MQ5 denotes CD40L
T555 4750-4755 Q9BDM3 denotes CD40L
T556 4750-4755 P63305 denotes CD40L
T557 4750-4755 Q9BDM7 denotes CD40L
T558 4750-4755 O97626 denotes CD40L
T559 4750-4755 O97605 denotes CD40L
T560 4750-4755 Q9Z2V2 denotes CD40L
T561 4750-4755 P63304 denotes CD40L
T562 4750-4755 Q9BDN3 denotes CD40L
T563 4750-4755 Q9I8D8 denotes CD40L
T564 4750-4755 P29965 denotes CD40L
T565 4750-4755 P51749 denotes CD40L
T566 4766-4775 MOP:0000569 denotes reduction
T567 4800-4805 D055418 denotes BMP-6
T568 4800-4805 D055418 denotes BMP-6
T569 4800-4805 Q04906 denotes BMP-6
T570 4800-4805 PR:000000167 denotes BMP-6
T571 4800-4805 P20722 denotes BMP-6
T572 4800-4805 PR:Q04906 denotes BMP-6
T573 4800-4805 P22004 denotes BMP-6
T574 4800-4805 PR:P22004 denotes BMP-6
T575 4800-4805 PR:P20722 denotes BMP-6
T576 4828-4841 UBERON:2000098 denotes proliferation
T577 4908-4924 D002051 denotes Burkitt lymphoma
T578 4908-4924 D002051 denotes Burkitt lymphoma
T579 4935-4940 CVCL_0597 denotes Ramos
T580 4946-4955 MOP:0000569 denotes reduction
T581 4959-4962 CHEBI:16991 denotes DNA
T582 4959-4962 D004247 denotes DNA
T583 4959-4962 GO:0005574 denotes DNA
T584 4959-4962 SO:0000352 denotes DNA
T585 4959-4972 GO:0071897 denotes DNA synthesis
T586 4990-4995 D055418 denotes BMP-6
T587 4990-4995 D055418 denotes BMP-6
T588 4990-4995 Q04906 denotes BMP-6
T589 4990-4995 PR:000000167 denotes BMP-6
T590 4990-4995 P20722 denotes BMP-6
T591 4990-4995 PR:Q04906 denotes BMP-6
T592 4990-4995 P22004 denotes BMP-6
T593 4990-4995 PR:P22004 denotes BMP-6
T594 4990-4995 PR:P20722 denotes BMP-6
T595 5041-5054 GO:0005576 denotes extracellular
T596 5055-5064 CHEBI:35222 denotes inhibitor
T597 5065-5071 P97466 denotes Noggin
T598 5065-5071 Q13253 denotes Noggin
T599 5065-5071 Q9YHT8 denotes Noggin
T600 5065-5071 PR:000000021 denotes Noggin
T601 5065-5071 O93525 denotes Noggin
T602 5065-5071 P49011 denotes Noggin
T603 5065-5071 Q62809 denotes Noggin
T604 5117-5124 GO:0005625 denotes soluble
T605 5125-5128 PR:000000034 denotes BMP
T606 5125-5128 P35855 denotes BMP
T607 5125-5138 D052004 denotes BMP receptors
T608 5129-5142 D052004 denotes receptors BMP
T609 5139-5142 PR:000000034 denotes BMP
T610 5139-5142 P35855 denotes BMP
T611 5143-5146 CHEBI:33942 denotes RIB
T612 5143-5146 UBERON:0002228 denotes RIB
T613 5154-5157 CHEBI:60815 denotes BMP
T614 5154-5157 PR:000000034 denotes BMP
T615 5154-5157 P35855 denotes BMP
T616 5197-5202 D055418 denotes BMP-6
T617 5197-5202 D055418 denotes BMP-6
T618 5197-5202 Q04906 denotes BMP-6
T619 5197-5202 PR:000000167 denotes BMP-6
T620 5197-5202 P20722 denotes BMP-6
T621 5197-5202 PR:Q04906 denotes BMP-6
T622 5197-5202 P22004 denotes BMP-6
T623 5197-5202 PR:P22004 denotes BMP-6
T624 5197-5202 PR:P20722 denotes BMP-6
T625 5209-5218 32644 denotes not shown
T626 5253-5258 D055418 denotes BMP-6
T627 5253-5258 D055418 denotes BMP-6
T628 5253-5258 Q04906 denotes BMP-6
T629 5253-5258 PR:000000167 denotes BMP-6
T630 5253-5258 P20722 denotes BMP-6
T631 5253-5258 PR:Q04906 denotes BMP-6
T632 5253-5258 P22004 denotes BMP-6
T633 5253-5258 PR:P22004 denotes BMP-6
T634 5253-5258 PR:P20722 denotes BMP-6
T635 5293-5299 GO:0007613 denotes memory
T636 5316-5320 PR:P25918 denotes CD19
T637 5316-5320 PR:P15391 denotes CD19
T638 5316-5320 PR:000001002 denotes CD19
T639 5321-5325 PR:P41272 denotes CD27
T640 5321-5325 PR:000001963 denotes CD27
T641 5321-5325 PR:P26842 denotes CD27
T642 5332-5338 GO:0007613 denotes memory
T643 5340-5344 PR:P25918 denotes CD19
T644 5340-5344 PR:P15391 denotes CD19
T645 5340-5344 PR:000001002 denotes CD19
T646 5345-5349 PR:P41272 denotes CD27
T647 5345-5349 PR:000001963 denotes CD27
T648 5345-5349 PR:P26842 denotes CD27
T649 5347-5353 CVCL_8997 denotes 27+) B
T650 5435-5439 PR:P25918 denotes CD19
T651 5435-5439 PR:P15391 denotes CD19
T652 5435-5439 PR:000001002 denotes CD19
T653 5519-5524 Q04906 denotes BMP-6
T654 5519-5524 PR:000000167 denotes BMP-6
T655 5519-5524 P20722 denotes BMP-6
T656 5519-5524 PR:Q04906 denotes BMP-6
T657 5519-5524 P22004 denotes BMP-6
T658 5519-5524 PR:P22004 denotes BMP-6
T659 5519-5524 PR:P20722 denotes BMP-6
T660 5519-5524 D055418 denotes BMP-6
T661 5519-5524 D055418 denotes BMP-6
T662 5535-5540 D055418 denotes BMP-6
T663 5535-5540 D055418 denotes BMP-6
T664 5535-5540 Q04906 denotes BMP-6
T665 5535-5540 PR:000000167 denotes BMP-6
T666 5535-5540 P20722 denotes BMP-6
T667 5535-5540 PR:Q04906 denotes BMP-6
T668 5535-5540 P22004 denotes BMP-6
T669 5535-5540 PR:P22004 denotes BMP-6
T670 5535-5540 PR:P20722 denotes BMP-6
T671 5551-5559 C044203 denotes anti-IgM
T672 5568-5571 CHEBI:16991 denotes DNA
T673 5568-5571 D004247 denotes DNA
T674 5568-5571 GO:0005574 denotes DNA
T675 5568-5571 SO:0000352 denotes DNA
T676 5568-5581 GO:0071897 denotes DNA synthesis
T677 5641-5650 MOP:0000569 denotes reduction
T678 5654-5657 CHEBI:16991 denotes DNA
T679 5654-5657 D004247 denotes DNA
T680 5654-5657 GO:0005574 denotes DNA
T681 5654-5657 SO:0000352 denotes DNA
T682 5654-5667 GO:0071897 denotes DNA-synthesis
T683 5743-5749 GO:0007613 denotes memory
T684 5772-5777 D055418 denotes BMP-6
T685 5772-5777 D055418 denotes BMP-6
T686 5772-5777 Q04906 denotes BMP-6
T687 5772-5777 PR:000000167 denotes BMP-6
T688 5772-5777 P20722 denotes BMP-6
T689 5772-5777 PR:Q04906 denotes BMP-6
T690 5772-5777 P22004 denotes BMP-6
T691 5772-5777 PR:P22004 denotes BMP-6
T692 5772-5777 PR:P20722 denotes BMP-6
T693 5786-5796 GO:0008219 denotes cell death
T694 5800-5805 D006801 denotes human
T695 5806-5812 GO:0007613 denotes memory
T696 5825-5830 CVCL_0597 denotes Ramos
T697 5874-5879 D055418 denotes BMP-6
T698 5874-5879 D055418 denotes BMP-6
T699 5874-5879 Q04906 denotes BMP-6
T700 5874-5879 PR:000000167 denotes BMP-6
T701 5874-5879 P20722 denotes BMP-6
T702 5874-5879 PR:Q04906 denotes BMP-6
T703 5874-5879 P22004 denotes BMP-6
T704 5874-5879 PR:P22004 denotes BMP-6
T705 5874-5879 PR:P20722 denotes BMP-6
T706 5964-5980 D011419 denotes propidium iodide
T707 5964-5980 D011419 denotes propidium iodide
T708 5964-5980 CHEBI:51240 denotes propidium iodide
T709 6025-6030 D055418 denotes BMP-6
T710 6025-6030 D055418 denotes BMP-6
T711 6025-6030 Q04906 denotes BMP-6
T712 6025-6030 PR:000000167 denotes BMP-6
T713 6025-6030 P20722 denotes BMP-6
T714 6025-6030 PR:Q04906 denotes BMP-6
T715 6025-6030 P22004 denotes BMP-6
T716 6025-6030 PR:P22004 denotes BMP-6
T717 6025-6030 PR:P20722 denotes BMP-6
T718 6060-6065 D055418 denotes BMP-6
T719 6060-6065 D055418 denotes BMP-6
T720 6060-6065 Q04906 denotes BMP-6
T721 6060-6065 PR:000000167 denotes BMP-6
T722 6060-6065 P20722 denotes BMP-6
T723 6060-6065 PR:Q04906 denotes BMP-6
T724 6060-6065 P22004 denotes BMP-6
T725 6060-6065 PR:P22004 denotes BMP-6
T726 6060-6065 PR:P20722 denotes BMP-6
T727 6116-6126 GO:0008219 denotes cell death
T728 6164-6172 C044203 denotes anti-IgM
T729 6184-6188 PR:P41272 denotes CD27
T730 6184-6188 PR:000001963 denotes CD27
T731 6184-6188 PR:P26842 denotes CD27
T732 6190-6196 GO:0007613 denotes memory
T733 6219-6224 CVCL_0597 denotes Ramos
T734 6257-6267 GO:0008219 denotes cell death
T735 6318-6323 D055418 denotes BMP-6
T736 6318-6323 D055418 denotes BMP-6
T737 6318-6323 Q04906 denotes BMP-6
T738 6318-6323 PR:000000167 denotes BMP-6
T739 6318-6323 P20722 denotes BMP-6
T740 6318-6323 PR:Q04906 denotes BMP-6
T741 6318-6323 P22004 denotes BMP-6
T742 6318-6323 PR:P22004 denotes BMP-6
T743 6318-6323 PR:P20722 denotes BMP-6
T744 6348-6358 GO:0008219 denotes cell death
T745 6368-6372 PR:P25918 denotes CD19
T746 6368-6372 PR:P15391 denotes CD19
T747 6368-6372 PR:000001002 denotes CD19
T748 6403-6412 32644 denotes not shown
T749 6417-6421 PR:P41272 denotes CD27
T750 6417-6421 PR:000001963 denotes CD27
T751 6417-6421 PR:P26842 denotes CD27
T752 6422-6425 D007074 denotes IgG
T753 6502-6507 D006801 denotes Human
T754 6524-6529 D055418 denotes BMP-6
T755 6524-6529 D055418 denotes BMP-6
T756 6524-6529 Q04906 denotes BMP-6
T757 6524-6529 PR:000000167 denotes BMP-6
T758 6524-6529 P20722 denotes BMP-6
T759 6524-6529 PR:Q04906 denotes BMP-6
T760 6524-6529 P22004 denotes BMP-6
T761 6524-6529 PR:P22004 denotes BMP-6
T762 6524-6529 PR:P20722 denotes BMP-6
T763 6593-6596 PR:000000034 denotes BMP
T764 6593-6596 P35855 denotes BMP
T765 6593-6606 D052004 denotes BMP receptors
T766 6687-6692 D006801 denotes human
T767 6760-6763 PR:000000034 denotes BMP
T768 6760-6763 P35855 denotes BMP
T769 6760-6773 D052004 denotes BMP receptors
T770 6833-6836 CHEBI:60815 denotes BMP
T771 6833-6836 PR:000000034 denotes BMP
T772 6833-6836 P35855 denotes BMP
T773 6837-6840 CHEBI:33942 denotes RIB
T774 6837-6840 UBERON:0002228 denotes RIB
T775 6857-6870 D052004 denotes receptors BMP
T776 6867-6870 PR:000000034 denotes BMP
T777 6867-6870 P35855 denotes BMP
T778 6913-6918 D006801 denotes human
T779 6939-6944 CVCL_0597 denotes Ramos
T780 6998-7001 CHEBI:60815 denotes BMP
T781 6998-7001 PR:000000034 denotes BMP
T782 6998-7001 P35855 denotes BMP
T783 7002-7005 CHEBI:33942 denotes RIB
T784 7002-7005 UBERON:0002228 denotes RIB
T785 7022-7034 D052004 denotes receptor BMP
T786 7031-7034 PR:000000034 denotes BMP
T787 7031-7034 P35855 denotes BMP
T788 7088-7092 CVCL_0002 denotes HL60
T789 7157-7160 CHEBI:60815 denotes BMP
T790 7157-7160 PR:000000034 denotes BMP
T791 7157-7160 P35855 denotes BMP
T792 7210-7215 D006801 denotes human
T793 7228-7233 CVCL_0597 denotes Ramos
T794 7257-7260 PR:000000034 denotes BMP
T795 7257-7260 P35855 denotes BMP
T796 7257-7270 D052004 denotes BMP receptors
T797 7297-7302 D055418 denotes BMP-6
T798 7297-7302 D055418 denotes BMP-6
T799 7297-7302 Q04906 denotes BMP-6
T800 7297-7302 PR:000000167 denotes BMP-6
T801 7297-7302 P20722 denotes BMP-6
T802 7297-7302 PR:Q04906 denotes BMP-6
T803 7297-7302 P22004 denotes BMP-6
T804 7297-7302 PR:P22004 denotes BMP-6
T805 7297-7302 PR:P20722 denotes BMP-6
T806 7310-7315 D055418 denotes BMP-6
T807 7310-7315 D055418 denotes BMP-6
T808 7310-7315 Q04906 denotes BMP-6
T809 7310-7315 PR:000000167 denotes BMP-6
T810 7310-7315 P20722 denotes BMP-6
T811 7310-7315 PR:Q04906 denotes BMP-6
T812 7310-7315 P22004 denotes BMP-6
T813 7310-7315 PR:P22004 denotes BMP-6
T814 7310-7315 PR:P20722 denotes BMP-6
T815 7324-7339 GO:0016310 denotes phosphorylation
T816 7343-7348 PR:Q9I8V2 denotes Smad1
T817 7343-7348 PR:P97588 denotes Smad1
T818 7343-7348 Q15797 denotes Smad1
T819 7343-7348 PR:000000363 denotes Smad1
T820 7343-7348 PR:P70340 denotes Smad1
T821 7343-7348 P70340 denotes Smad1
T822 7343-7348 Q9I962 denotes Smad1
T823 7343-7348 PR:Q15797 denotes Smad1
T824 7343-7348 P97588 denotes Smad1
T825 7343-7348 Q9I8V2 denotes Smad1
T826 7343-7348 Q1JQA2 denotes Smad1
T827 7358-7364 CHEBI:52214 denotes ligand
T828 7358-7364 GO:0005488 denotes ligand
T829 7365-7372 GO:0005488 denotes binding
T830 7365-7372 SO:0100018 denotes binding
T831 7365-7372 SO:0001091 denotes binding
T832 7471-7477 SO:0000725 denotes signal
T833 7471-7477 SO:0000418 denotes signal
T834 7526-7531 D055418 denotes BMP-6
T835 7526-7531 D055418 denotes BMP-6
T836 7526-7531 Q04906 denotes BMP-6
T837 7526-7531 PR:000000167 denotes BMP-6
T838 7526-7531 P20722 denotes BMP-6
T839 7526-7531 PR:Q04906 denotes BMP-6
T840 7526-7531 P22004 denotes BMP-6
T841 7526-7531 PR:P22004 denotes BMP-6
T842 7526-7531 PR:P20722 denotes BMP-6
T843 7540-7555 GO:0016310 denotes phosphorylation
T844 7611-7629 GO:0007165 denotes signalling pathway
T845 7622-7629 CHEBI:34922 denotes pathway
T846 7670-7675 UBERON:0001977 denotes serum
T847 7670-7686 D016895 denotes serum-free media
T848 7720-7725 D055418 denotes BMP-6
T849 7720-7725 D055418 denotes BMP-6
T850 7720-7725 Q04906 denotes BMP-6
T851 7720-7725 PR:000000167 denotes BMP-6
T852 7720-7725 P20722 denotes BMP-6
T853 7720-7725 PR:Q04906 denotes BMP-6
T854 7720-7725 P22004 denotes BMP-6
T855 7720-7725 PR:P22004 denotes BMP-6
T856 7720-7725 PR:P20722 denotes BMP-6
T857 7757-7764 GO:0003675 denotes protein
T858 7757-7764 CHEBI:36080 denotes protein
T859 7757-7764 CHEBI:11122 denotes protein
T860 7757-7764 PR:000000001 denotes protein
T861 7757-7764 SO:0000104 denotes protein
T862 7835-7840 PR:Q9I8V2 denotes Smad1
T863 7835-7840 PR:P97588 denotes Smad1
T864 7835-7840 Q15797 denotes Smad1
T865 7835-7840 PR:000000363 denotes Smad1
T866 7835-7840 PR:P70340 denotes Smad1
T867 7835-7840 P70340 denotes Smad1
T868 7835-7840 Q9I962 denotes Smad1
T869 7835-7840 PR:Q15797 denotes Smad1
T870 7835-7840 P97588 denotes Smad1
T871 7835-7840 Q9I8V2 denotes Smad1
T872 7835-7840 Q1JQA2 denotes Smad1
T873 7927-7932 D055418 denotes BMP-6
T874 7927-7932 D055418 denotes BMP-6
T875 7927-7932 Q04906 denotes BMP-6
T876 7927-7932 PR:000000167 denotes BMP-6
T877 7927-7932 P20722 denotes BMP-6
T878 7927-7932 PR:Q04906 denotes BMP-6
T879 7927-7932 P22004 denotes BMP-6
T880 7927-7932 PR:P22004 denotes BMP-6
T881 7927-7932 PR:P20722 denotes BMP-6
T882 7941-7956 GO:0016310 denotes phosphorylation
T883 7970-7975 D055418 denotes BMP-6
T884 7970-7975 D055418 denotes BMP-6
T885 7970-7975 Q04906 denotes BMP-6
T886 7970-7975 PR:000000167 denotes BMP-6
T887 7970-7975 P20722 denotes BMP-6
T888 7970-7975 PR:Q04906 denotes BMP-6
T889 7970-7975 P22004 denotes BMP-6
T890 7970-7975 PR:P22004 denotes BMP-6
T891 7970-7975 PR:P20722 denotes BMP-6
T892 7984-7999 GO:0016310 denotes phosphorylation
T893 8119-8134 GO:0016310 denotes phosphorylation
T894 8151-8156 CVCL_0597 denotes Ramos
T895 8175-8179 CVCL_0002 denotes HL60
T896 8246-8256 SO:0001633 denotes downstream
T897 8257-8267 GO:0023052 denotes signalling
T898 8280-8285 D055418 denotes BMP-6
T899 8280-8285 D055418 denotes BMP-6
T900 8280-8285 Q04906 denotes BMP-6
T901 8280-8285 PR:000000167 denotes BMP-6
T902 8280-8285 P20722 denotes BMP-6
T903 8280-8285 PR:Q04906 denotes BMP-6
T904 8280-8285 P22004 denotes BMP-6
T905 8280-8285 PR:P22004 denotes BMP-6
T906 8280-8285 PR:P20722 denotes BMP-6
T907 8308-8313 D055418 denotes BMP-6
T908 8308-8313 D055418 denotes BMP-6
T909 8308-8313 Q04906 denotes BMP-6
T910 8308-8313 PR:000000167 denotes BMP-6
T911 8308-8313 P20722 denotes BMP-6
T912 8308-8313 PR:Q04906 denotes BMP-6
T913 8308-8313 P22004 denotes BMP-6
T914 8308-8313 PR:P22004 denotes BMP-6
T915 8308-8313 PR:P20722 denotes BMP-6
T916 8317-8322 D006801 denotes human
T917 8400-8407 CHEBI:48108 denotes phospho
T918 8408-8413 PR:000002089 denotes STAT3
T919 8408-8413 PR:P42227 denotes STAT3
T920 8408-8413 PR:Q6DV79 denotes STAT3
T921 8408-8413 PR:P40763 denotes STAT3
T922 8408-8413 PR:P52631 denotes STAT3
T923 8417-8424 CHEBI:48108 denotes phospho
T924 8425-8428 PR:000005882 denotes p38
T925 8425-8428 O24473 denotes p38
T926 8425-8428 P46108 denotes p38
T927 8425-8428 Q64010 denotes p38
T928 8425-8428 A0A0H3M950 denotes p38
T929 8425-8428 P0C797 denotes p38
T930 8425-8428 P04383 denotes p38
T931 8425-8428 O95433 denotes p38
T932 8425-8428 Q63768 denotes p38
T933 8425-8428 PR:Q9LDA4 denotes p38
T934 8425-8428 P06663 denotes p38
T935 8425-8428 P0C796 denotes p38
T936 8425-8428 PR:000003860 denotes p38
T937 8425-8428 Q9NV58 denotes p38
T938 8425-8428 O75791 denotes p38
T939 8425-8428 PR:000008220 denotes p38
T940 8425-8428 A0A0H3MBK5 denotes p38
T941 8425-8428 P80350 denotes p38
T942 8425-8428 PR:000012967 denotes p38
T943 8425-8428 O97628 denotes p38
T944 8425-8428 A0A0H3MBL5 denotes p38
T945 8425-8428 Q9Y2S7 denotes p38
T946 8425-8428 PR:000014113 denotes p38
T947 8425-8428 P82869 denotes p38
T948 8425-8428 Q9Q6X7 denotes p38
T949 8425-8428 P9WGU1 denotes p38
T950 8425-8428 Q04929 denotes p38
T951 8434-8439 D055418 denotes BMP-6
T952 8434-8439 D055418 denotes BMP-6
T953 8434-8439 Q04906 denotes BMP-6
T954 8434-8439 PR:000000167 denotes BMP-6
T955 8434-8439 P20722 denotes BMP-6
T956 8434-8439 PR:Q04906 denotes BMP-6
T957 8434-8439 P22004 denotes BMP-6
T958 8434-8439 PR:P22004 denotes BMP-6
T959 8434-8439 PR:P20722 denotes BMP-6
T960 8467-8476 32644 denotes not shown
T961 8480-8485 D055418 denotes BMP-6
T962 8480-8485 D055418 denotes BMP-6
T963 8480-8485 Q04906 denotes BMP-6
T964 8480-8485 PR:000000167 denotes BMP-6
T965 8480-8485 P20722 denotes BMP-6
T966 8480-8485 PR:Q04906 denotes BMP-6
T967 8480-8485 P22004 denotes BMP-6
T968 8480-8485 PR:P22004 denotes BMP-6
T969 8480-8485 PR:P20722 denotes BMP-6
T970 8510-8513 PR:P41134 denotes Id1
T971 8510-8513 PR:P20067 denotes Id1
T972 8510-8513 PR:P41135 denotes Id1
T973 8510-8513 PR:000000039 denotes Id1
T974 8553-8558 D055418 denotes BMP-6
T975 8553-8558 D055418 denotes BMP-6
T976 8553-8558 Q04906 denotes BMP-6
T977 8553-8558 PR:000000167 denotes BMP-6
T978 8553-8558 P20722 denotes BMP-6
T979 8553-8558 PR:Q04906 denotes BMP-6
T980 8553-8558 P22004 denotes BMP-6
T981 8553-8558 PR:P22004 denotes BMP-6
T982 8553-8558 PR:P20722 denotes BMP-6
T983 8567-8582 GO:0016310 denotes phosphorylation
T984 8586-8592 PR:Q9I8V2 denotes Smad 1
T985 8586-8592 PR:P97588 denotes Smad 1
T986 8586-8592 Q15797 denotes Smad 1
T987 8586-8592 PR:000000363 denotes Smad 1
T988 8586-8592 PR:P70340 denotes Smad 1
T989 8586-8592 P70340 denotes Smad 1
T990 8586-8592 Q9I962 denotes Smad 1
T991 8586-8592 PR:Q15797 denotes Smad 1
T992 8586-8592 P97588 denotes Smad 1
T993 8586-8592 Q9I8V2 denotes Smad 1
T994 8586-8592 Q1JQA2 denotes Smad 1
T995 8676-8686 CHEBI:35222 denotes inhibitors
T996 8690-8693 GO:0005574 denotes DNA
T997 8690-8693 SO:0000352 denotes DNA
T998 8690-8701 GO:0003677 denotes DNA binding
T999 8690-8710 D004268 denotes DNA binding proteins
T1000 8694-8701 SO:0100018 denotes binding
T1001 8694-8701 SO:0001091 denotes binding
T1002 8712-8715 PR:Q08890 denotes Ids
T1003 8712-8715 PR:000008894 denotes Ids
T1004 8712-8715 PR:P22304 denotes Ids
T1005 8778-8788 GO:0023052 denotes signalling
T1006 8814-8817 GO:0003904 denotes pre
T1007 8814-8817 PR:Q8LLD0 denotes pre
T1008 8814-8817 SO:0002045 denotes pre
T1009 8814-8817 UBERON:0001782 denotes pre
T1010 8909-8914 Q04906 denotes BMP-6
T1011 8909-8914 PR:000000167 denotes BMP-6
T1012 8909-8914 P20722 denotes BMP-6
T1013 8909-8914 PR:Q04906 denotes BMP-6
T1014 8909-8914 P22004 denotes BMP-6
T1015 8909-8914 PR:P22004 denotes BMP-6
T1016 8909-8914 PR:P20722 denotes BMP-6
T1017 8909-8914 D055418 denotes BMP-6
T1018 8909-8914 D055418 denotes BMP-6
T1019 8967-8970 SO:0000356 denotes RNA
T1020 8967-8970 CHEBI:33697 denotes RNA
T1021 8967-8970 D012313 denotes RNA
T1022 8967-8970 GO:0005562 denotes RNA
T1023 8986-8989 PR:P41134 denotes Id1
T1024 8986-8989 PR:P20067 denotes Id1
T1025 8986-8989 PR:P41135 denotes Id1
T1026 8986-8989 PR:000000039 denotes Id1
T1027 8990-8993 PR:P47928 denotes Id4
T1028 8990-8993 PR:P41139 denotes Id4
T1029 8990-8993 PR:000000042 denotes Id4
T1030 8994-8998 D012333 denotes mRNA
T1031 8994-8998 CHEBI:33699 denotes mRNA
T1032 8994-8998 SO:0000234 denotes mRNA
T1033 9030-9033 Q41249 denotes PCR
T1034 9030-9033 O66148 denotes PCR
T1035 9030-9033 Q59987 denotes PCR
T1036 9030-9033 Q01289 denotes PCR
T1037 9030-9033 O80333 denotes PCR
T1038 9030-9033 P15904 denotes PCR
T1039 9030-9033 Q9SDT1 denotes PCR
T1040 9030-9033 Q39617 denotes PCR
T1041 9078-9082 PR:000022679 denotes fold
T1042 9078-9082 PR:Q2FZJ6 denotes fold
T1043 9078-9082 PR:A5I112 denotes fold
T1044 9078-9082 PR:P24186 denotes fold
T1045 9099-9102 PR:P41134 denotes Id1
T1046 9099-9102 PR:P20067 denotes Id1
T1047 9099-9102 PR:P41135 denotes Id1
T1048 9099-9102 PR:000000039 denotes Id1
T1049 9103-9107 D012333 denotes mRNA
T1050 9103-9107 CHEBI:33699 denotes mRNA
T1051 9103-9107 SO:0000234 denotes mRNA
T1052 9111-9116 Q04906 denotes BMP-6
T1053 9111-9116 PR:000000167 denotes BMP-6
T1054 9111-9116 P20722 denotes BMP-6
T1055 9111-9116 PR:Q04906 denotes BMP-6
T1056 9111-9116 P22004 denotes BMP-6
T1057 9111-9116 PR:P22004 denotes BMP-6
T1058 9111-9116 PR:P20722 denotes BMP-6
T1059 9111-9116 D055418 denotes BMP-6
T1060 9111-9116 D055418 denotes BMP-6
T1061 9152-9162 GO:0065007 denotes regulation
T1062 9166-9169 PR:P41134 denotes Id1
T1063 9166-9169 PR:P20067 denotes Id1
T1064 9166-9169 PR:P41135 denotes Id1
T1065 9166-9169 PR:000000039 denotes Id1
T1066 9170-9174 D012333 denotes mRNA
T1067 9170-9174 CHEBI:33699 denotes mRNA
T1068 9170-9174 SO:0000234 denotes mRNA
T1069 9216-9220 SO:0000704 denotes gene
T1070 9280-9285 Q04906 denotes BMP-6
T1071 9280-9285 PR:000000167 denotes BMP-6
T1072 9280-9285 P20722 denotes BMP-6
T1073 9280-9285 PR:Q04906 denotes BMP-6
T1074 9280-9285 P22004 denotes BMP-6
T1075 9280-9285 PR:P22004 denotes BMP-6
T1076 9280-9285 PR:P20722 denotes BMP-6
T1077 9280-9285 D055418 denotes BMP-6
T1078 9280-9285 D055418 denotes BMP-6
T1079 9381-9384 PR:000000040 denotes Id2
T1080 9381-9384 PR:P41137 denotes Id2
T1081 9381-9384 PR:Q02363 denotes Id2
T1082 9381-9384 PR:P41136 denotes Id2
T1083 9381-9384 C039556 denotes Id2
T1084 9381-9384 C039556 denotes Id2
T1085 9389-9392 PR:P41133 denotes Id3
T1086 9389-9392 PR:P41138 denotes Id3
T1087 9389-9392 PR:Q02535 denotes Id3
T1088 9389-9392 PR:000000041 denotes Id3
T1089 9393-9397 D012333 denotes mRNA
T1090 9393-9397 CHEBI:33699 denotes mRNA
T1091 9393-9397 SO:0000234 denotes mRNA
T1092 9407-9410 PR:P47928 denotes Id4
T1093 9407-9410 PR:P41139 denotes Id4
T1094 9407-9410 PR:000000042 denotes Id4
T1095 9459-9468 32644 denotes not shown
T1096 9511-9516 D055418 denotes BMP-6
T1097 9511-9516 D055418 denotes BMP-6
T1098 9511-9516 Q04906 denotes BMP-6
T1099 9511-9516 PR:000000167 denotes BMP-6
T1100 9511-9516 P20722 denotes BMP-6
T1101 9511-9516 PR:Q04906 denotes BMP-6
T1102 9511-9516 P22004 denotes BMP-6
T1103 9511-9516 PR:P22004 denotes BMP-6
T1104 9511-9516 PR:P20722 denotes BMP-6
T1105 9541-9544 PR:P41134 denotes Id1
T1106 9541-9544 PR:P20067 denotes Id1
T1107 9541-9544 PR:P41135 denotes Id1
T1108 9541-9544 PR:000000039 denotes Id1
T1109 9545-9549 D012333 denotes mRNA
T1110 9545-9549 CHEBI:33699 denotes mRNA
T1111 9545-9549 SO:0000234 denotes mRNA
T1112 9591-9594 PR:P41134 denotes Id1
T1113 9591-9594 PR:P20067 denotes Id1
T1114 9591-9594 PR:P41135 denotes Id1
T1115 9591-9594 PR:000000039 denotes Id1
T1116 9595-9602 CHEBI:36080 denotes protein
T1117 9595-9602 CHEBI:11122 denotes protein
T1118 9595-9602 PR:000000001 denotes protein
T1119 9595-9602 SO:0000104 denotes protein
T1120 9595-9602 GO:0003675 denotes protein
T1121 9628-9631 PR:P41134 denotes Id1
T1122 9628-9631 PR:P20067 denotes Id1
T1123 9628-9631 PR:P41135 denotes Id1
T1124 9628-9631 PR:000000039 denotes Id1
T1125 9632-9639 PR:000000001 denotes protein
T1126 9632-9639 GO:0003675 denotes protein
T1127 9632-9639 CHEBI:36080 denotes protein
T1128 9632-9639 CHEBI:11122 denotes protein
T1129 9632-9639 SO:0000104 denotes protein
T1130 9711-9716 Q04906 denotes BMP-6
T1131 9711-9716 PR:000000167 denotes BMP-6
T1132 9711-9716 P20722 denotes BMP-6
T1133 9711-9716 PR:Q04906 denotes BMP-6
T1134 9711-9716 P22004 denotes BMP-6
T1135 9711-9716 PR:P22004 denotes BMP-6
T1136 9711-9716 PR:P20722 denotes BMP-6
T1137 9711-9716 D055418 denotes BMP-6
T1138 9711-9716 D055418 denotes BMP-6
T1139 9740-9744 PR:000022679 denotes fold
T1140 9740-9744 PR:Q2FZJ6 denotes fold
T1141 9740-9744 PR:A5I112 denotes fold
T1142 9740-9744 PR:P24186 denotes fold
T1143 9829-9833 D012333 denotes mRNA
T1144 9829-9833 CHEBI:33699 denotes mRNA
T1145 9829-9833 SO:0000234 denotes mRNA
T1146 9879-9882 C039556 denotes Id2
T1147 9879-9882 C039556 denotes Id2
T1148 9879-9882 PR:000000040 denotes Id2
T1149 9879-9882 PR:P41137 denotes Id2
T1150 9879-9882 PR:Q02363 denotes Id2
T1151 9879-9882 PR:P41136 denotes Id2
T1152 9887-9890 PR:P41133 denotes Id3
T1153 9887-9890 PR:P41138 denotes Id3
T1154 9887-9890 PR:Q02535 denotes Id3
T1155 9887-9890 PR:000000041 denotes Id3
T1156 9891-9898 CHEBI:36080 denotes protein
T1157 9891-9898 CHEBI:11122 denotes protein
T1158 9891-9898 SO:0000104 denotes protein
T1159 9891-9898 PR:000000001 denotes protein
T1160 9891-9898 GO:0003675 denotes protein
T1161 9961-9964 PR:P41134 denotes Id1
T1162 9961-9964 PR:P20067 denotes Id1
T1163 9961-9964 PR:P41135 denotes Id1
T1164 9961-9964 PR:000000039 denotes Id1
T1165 9974-9978 CL:0000560 denotes band
T1166 9995-10002 PR:000018264 denotes peptide
T1167 9995-10002 PR:000018263 denotes peptide
T1168 9995-10002 SO:0001064 denotes peptide
T1169 9995-10002 CHEBI:16670 denotes peptide
T1170 10009-10018 32644 denotes not shown
T1171 10061-10064 PR:P41134 denotes Id1
T1172 10061-10064 PR:P20067 denotes Id1
T1173 10061-10064 PR:P41135 denotes Id1
T1174 10061-10064 PR:000000039 denotes Id1
T1175 10085-10096 SO:0001867 denotes target gene
T1176 10126-10131 Q04906 denotes BMP-6
T1177 10126-10131 PR:000000167 denotes BMP-6
T1178 10126-10131 P20722 denotes BMP-6
T1179 10126-10131 PR:Q04906 denotes BMP-6
T1180 10126-10131 P22004 denotes BMP-6
T1181 10126-10131 PR:P22004 denotes BMP-6
T1182 10126-10131 PR:P20722 denotes BMP-6
T1183 10126-10131 D055418 denotes BMP-6
T1184 10126-10131 D055418 denotes BMP-6
T1185 10135-10140 D006801 denotes human
T1186 10158-10161 PR:000000040 denotes Id2
T1187 10158-10161 PR:P41137 denotes Id2
T1188 10158-10161 PR:Q02363 denotes Id2
T1189 10158-10161 PR:P41136 denotes Id2
T1190 10158-10161 C039556 denotes Id2
T1191 10158-10161 C039556 denotes Id2
T1192 10166-10169 PR:P41133 denotes Id3
T1193 10166-10169 PR:P41138 denotes Id3
T1194 10166-10169 PR:Q02535 denotes Id3
T1195 10166-10169 PR:000000041 denotes Id3
T1196 10196-10201 D055418 denotes BMP-6
T1197 10196-10201 D055418 denotes BMP-6
T1198 10196-10201 Q04906 denotes BMP-6
T1199 10196-10201 PR:000000167 denotes BMP-6
T1200 10196-10201 P20722 denotes BMP-6
T1201 10196-10201 PR:Q04906 denotes BMP-6
T1202 10196-10201 P22004 denotes BMP-6
T1203 10196-10201 PR:P22004 denotes BMP-6
T1204 10196-10201 PR:P20722 denotes BMP-6
T1205 10238-10243 D055418 denotes BMP-6
T1206 10238-10243 D055418 denotes BMP-6
T1207 10238-10243 Q04906 denotes BMP-6
T1208 10238-10243 PR:000000167 denotes BMP-6
T1209 10238-10243 P20722 denotes BMP-6
T1210 10238-10243 PR:Q04906 denotes BMP-6
T1211 10238-10243 P22004 denotes BMP-6
T1212 10238-10243 PR:P22004 denotes BMP-6
T1213 10238-10243 PR:P20722 denotes BMP-6
T1214 10321-10328 UBERON:0000992 denotes ovarium
T1215 10377-10382 D006801 denotes human
T1216 10405-10410 D055418 denotes BMP-6
T1217 10405-10410 D055418 denotes BMP-6
T1218 10405-10410 Q04906 denotes BMP-6
T1219 10405-10410 PR:000000167 denotes BMP-6
T1220 10405-10410 P20722 denotes BMP-6
T1221 10405-10410 PR:Q04906 denotes BMP-6
T1222 10405-10410 P22004 denotes BMP-6
T1223 10405-10410 PR:P22004 denotes BMP-6
T1224 10405-10410 PR:P20722 denotes BMP-6
T1225 10429-10434 CVCL_0597 denotes Ramos
T1226 10479-10484 D055418 denotes BMP-6
T1227 10479-10484 D055418 denotes BMP-6
T1228 10479-10484 Q04906 denotes BMP-6
T1229 10479-10484 PR:000000167 denotes BMP-6
T1230 10479-10484 P20722 denotes BMP-6
T1231 10479-10484 PR:Q04906 denotes BMP-6
T1232 10479-10484 P22004 denotes BMP-6
T1233 10479-10484 PR:P22004 denotes BMP-6
T1234 10479-10484 PR:P20722 denotes BMP-6
T1235 10485-10489 D012333 denotes mRNA
T1236 10485-10489 CHEBI:33699 denotes mRNA
T1237 10485-10489 SO:0000234 denotes mRNA
T1238 10517-10523 CL:0000084 denotes T cell
T1239 10529-10535 CVCL_0065 denotes Jurkat
T1240 10604-10609 D055418 denotes BMP-6
T1241 10604-10609 D055418 denotes BMP-6
T1242 10604-10609 Q04906 denotes BMP-6
T1243 10604-10609 PR:000000167 denotes BMP-6
T1244 10604-10609 P20722 denotes BMP-6
T1245 10604-10609 PR:Q04906 denotes BMP-6
T1246 10604-10609 P22004 denotes BMP-6
T1247 10604-10609 PR:P22004 denotes BMP-6
T1248 10604-10609 PR:P20722 denotes BMP-6
T1249 10610-10614 D012333 denotes mRNA
T1250 10610-10614 CHEBI:33699 denotes mRNA
T1251 10610-10614 SO:0000234 denotes mRNA
T1252 10672-10675 Q41249 denotes PCR
T1253 10672-10675 O66148 denotes PCR
T1254 10672-10675 Q59987 denotes PCR
T1255 10672-10675 Q01289 denotes PCR
T1256 10672-10675 O80333 denotes PCR
T1257 10672-10675 P15904 denotes PCR
T1258 10672-10675 Q9SDT1 denotes PCR
T1259 10672-10675 Q39617 denotes PCR
T1260 10699-10707 C044203 denotes anti-IgM
T1261 10757-10767 GO:0065007 denotes regulation
T1262 10771-10776 D055418 denotes BMP-6
T1263 10771-10776 D055418 denotes BMP-6
T1264 10771-10776 Q04906 denotes BMP-6
T1265 10771-10776 PR:000000167 denotes BMP-6
T1266 10771-10776 P20722 denotes BMP-6
T1267 10771-10776 PR:Q04906 denotes BMP-6
T1268 10771-10776 P22004 denotes BMP-6
T1269 10771-10776 PR:P22004 denotes BMP-6
T1270 10771-10776 PR:P20722 denotes BMP-6
T1271 10777-10781 D012333 denotes mRNA
T1272 10777-10781 CHEBI:33699 denotes mRNA
T1273 10777-10781 SO:0000234 denotes mRNA
T1274 10816-10828 SO:0000933 denotes intermediate
T1275 10839-10843 SO:0000704 denotes gene
T1276 10903-10911 C044203 denotes anti-IgM
T1277 10926-10931 D055418 denotes BMP-6
T1278 10926-10931 D055418 denotes BMP-6
T1279 10926-10931 Q04906 denotes BMP-6
T1280 10926-10931 PR:000000167 denotes BMP-6
T1281 10926-10931 P20722 denotes BMP-6
T1282 10926-10931 PR:Q04906 denotes BMP-6
T1283 10926-10931 P22004 denotes BMP-6
T1284 10926-10931 PR:P22004 denotes BMP-6
T1285 10926-10931 PR:P20722 denotes BMP-6
T1286 10932-10936 D012333 denotes mRNA
T1287 10932-10936 CHEBI:33699 denotes mRNA
T1288 10932-10936 SO:0000234 denotes mRNA
T1289 11029-11034 D006801 denotes human
T1290 11038-11043 UBERON:0001977 denotes serum
T1291 11080-11085 D055418 denotes BMP-6
T1292 11080-11085 D055418 denotes BMP-6
T1293 11080-11085 Q04906 denotes BMP-6
T1294 11080-11085 PR:000000167 denotes BMP-6
T1295 11080-11085 P20722 denotes BMP-6
T1296 11080-11085 PR:Q04906 denotes BMP-6
T1297 11080-11085 P22004 denotes BMP-6
T1298 11080-11085 PR:P22004 denotes BMP-6
T1299 11080-11085 PR:P20722 denotes BMP-6
T1300 11086-11090 D012333 denotes mRNA
T1301 11086-11090 CHEBI:33699 denotes mRNA
T1302 11086-11090 SO:0000234 denotes mRNA
T1303 11165-11170 D006801 denotes human
T1304 11194-11199 D055418 denotes BMP-6
T1305 11194-11199 D055418 denotes BMP-6
T1306 11194-11199 Q04906 denotes BMP-6
T1307 11194-11199 PR:000000167 denotes BMP-6
T1308 11194-11199 P20722 denotes BMP-6
T1309 11194-11199 PR:Q04906 denotes BMP-6
T1310 11194-11199 P22004 denotes BMP-6
T1311 11194-11199 PR:P22004 denotes BMP-6
T1312 11194-11199 PR:P20722 denotes BMP-6
T1313 11200-11204 D012333 denotes mRNA
T1314 11200-11204 CHEBI:33699 denotes mRNA
T1315 11200-11204 SO:0000234 denotes mRNA
T1316 11294-11299 D055418 denotes BMP-6
T1317 11294-11299 D055418 denotes BMP-6
T1318 11294-11299 Q04906 denotes BMP-6
T1319 11294-11299 PR:000000167 denotes BMP-6
T1320 11294-11299 P20722 denotes BMP-6
T1321 11294-11299 PR:Q04906 denotes BMP-6
T1322 11294-11299 P22004 denotes BMP-6
T1323 11294-11299 PR:P22004 denotes BMP-6
T1324 11294-11299 PR:P20722 denotes BMP-6
T1325 11300-11307 CHEBI:36080 denotes protein
T1326 11300-11307 CHEBI:11122 denotes protein
T1327 11300-11307 PR:000000001 denotes protein
T1328 11300-11307 GO:0003675 denotes protein
T1329 11300-11307 SO:0000104 denotes protein
T1330 11368-11378 D000906 denotes antibodies
T1331 11413-11418 D055418 denotes BMP-6
T1332 11413-11418 D055418 denotes BMP-6
T1333 11413-11418 Q04906 denotes BMP-6
T1334 11413-11418 PR:000000167 denotes BMP-6
T1335 11413-11418 P20722 denotes BMP-6
T1336 11413-11418 PR:Q04906 denotes BMP-6
T1337 11413-11418 P22004 denotes BMP-6
T1338 11413-11418 PR:P22004 denotes BMP-6
T1339 11413-11418 PR:P20722 denotes BMP-6
T1340 11419-11429 D000906 denotes antibodies
T1341 11465-11470 D055418 denotes BMP-6
T1342 11465-11470 D055418 denotes BMP-6
T1343 11465-11470 Q04906 denotes BMP-6
T1344 11465-11470 PR:000000167 denotes BMP-6
T1345 11465-11470 P20722 denotes BMP-6
T1346 11465-11470 PR:Q04906 denotes BMP-6
T1347 11465-11470 P22004 denotes BMP-6
T1348 11465-11470 PR:P22004 denotes BMP-6
T1349 11465-11470 PR:P20722 denotes BMP-6
T1350 11471-11478 CHEBI:36080 denotes protein
T1351 11471-11478 CHEBI:11122 denotes protein
T1352 11471-11478 PR:000000001 denotes protein
T1353 11471-11478 GO:0003675 denotes protein
T1354 11471-11478 SO:0000104 denotes protein
T1355 11498-11505 CHEBI:36080 denotes protein
T1356 11498-11505 CHEBI:11122 denotes protein
T1357 11498-11505 PR:000000001 denotes protein
T1358 11498-11505 GO:0003675 denotes protein
T1359 11498-11505 SO:0000104 denotes protein
T1360 11574-11577 CHEBI:60815 denotes BMP
T1361 11574-11577 PR:000000034 denotes BMP
T1362 11574-11577 P35855 denotes BMP
T1363 11654-11660 CL:0000236 denotes B-cell
T1364 11661-11673 D009369 denotes malignancies
T1365 11661-11673 D009369 denotes malignancies
T1366 11715-11720 D006801 denotes human
T1367 11836-11841 D055418 denotes BMP-6
T1368 11836-11841 D055418 denotes BMP-6
T1369 11836-11841 Q04906 denotes BMP-6
T1370 11836-11841 PR:000000167 denotes BMP-6
T1371 11836-11841 P20722 denotes BMP-6
T1372 11836-11841 PR:Q04906 denotes BMP-6
T1373 11836-11841 P22004 denotes BMP-6
T1374 11836-11841 PR:P22004 denotes BMP-6
T1375 11836-11841 PR:P20722 denotes BMP-6
T1376 11862-11866 PR:P25918 denotes CD19
T1377 11862-11866 PR:P15391 denotes CD19
T1378 11862-11866 PR:000001002 denotes CD19
T1379 11891-11896 D055418 denotes BMP-6
T1380 11891-11896 D055418 denotes BMP-6
T1381 11891-11896 Q04906 denotes BMP-6
T1382 11891-11896 PR:000000167 denotes BMP-6
T1383 11891-11896 P20722 denotes BMP-6
T1384 11891-11896 PR:Q04906 denotes BMP-6
T1385 11891-11896 P22004 denotes BMP-6
T1386 11891-11896 PR:P22004 denotes BMP-6
T1387 11891-11896 PR:P20722 denotes BMP-6
T1388 11905-11915 GO:0008219 denotes cell death
T1389 11919-11923 PR:P41272 denotes CD27
T1390 11919-11923 PR:000001963 denotes CD27
T1391 11919-11923 PR:P26842 denotes CD27
T1392 11925-11931 GO:0007613 denotes memory
T1393 11956-11972 D002051 denotes Burkitt lymphoma
T1394 11956-11972 D002051 denotes Burkitt lymphoma
T1395 11984-11989 CVCL_0597 denotes Ramos
T1396 12005-12010 D055418 denotes BMP-6
T1397 12005-12010 D055418 denotes BMP-6
T1398 12005-12010 Q04906 denotes BMP-6
T1399 12005-12010 PR:000000167 denotes BMP-6
T1400 12005-12010 P20722 denotes BMP-6
T1401 12005-12010 PR:Q04906 denotes BMP-6
T1402 12005-12010 P22004 denotes BMP-6
T1403 12005-12010 PR:P22004 denotes BMP-6
T1404 12005-12010 PR:P20722 denotes BMP-6
T1405 12050-12056 PR:Q9I8V2 denotes Smad-1
T1406 12050-12056 PR:P97588 denotes Smad-1
T1407 12050-12056 Q15797 denotes Smad-1
T1408 12050-12056 PR:000000363 denotes Smad-1
T1409 12050-12056 PR:P70340 denotes Smad-1
T1410 12050-12056 P70340 denotes Smad-1
T1411 12050-12056 Q9I962 denotes Smad-1
T1412 12050-12056 PR:Q15797 denotes Smad-1
T1413 12050-12056 P97588 denotes Smad-1
T1414 12050-12056 Q9I8V2 denotes Smad-1
T1415 12050-12056 Q1JQA2 denotes Smad-1
T1416 12061-12076 GO:0016310 denotes phosphorylation
T1417 12095-12100 D055418 denotes BMP-6
T1418 12095-12100 D055418 denotes BMP-6
T1419 12095-12100 Q04906 denotes BMP-6
T1420 12095-12100 PR:000000167 denotes BMP-6
T1421 12095-12100 P20722 denotes BMP-6
T1422 12095-12100 PR:Q04906 denotes BMP-6
T1423 12095-12100 P22004 denotes BMP-6
T1424 12095-12100 PR:P22004 denotes BMP-6
T1425 12095-12100 PR:P20722 denotes BMP-6
T1426 12114-12129 GO:0016310 denotes phosphorylation
T1427 12174-12177 PR:P41134 denotes Id1
T1428 12174-12177 PR:P20067 denotes Id1
T1429 12174-12177 PR:P41135 denotes Id1
T1430 12174-12177 PR:000000039 denotes Id1
T1431 12178-12182 D012333 denotes mRNA
T1432 12178-12182 CHEBI:33699 denotes mRNA
T1433 12178-12182 SO:0000234 denotes mRNA
T1434 12198-12201 PR:P41134 denotes Id1
T1435 12198-12201 PR:P20067 denotes Id1
T1436 12198-12201 PR:P41135 denotes Id1
T1437 12198-12201 PR:000000039 denotes Id1
T1438 12202-12209 CHEBI:36080 denotes protein
T1439 12202-12209 CHEBI:11122 denotes protein
T1440 12202-12209 PR:000000001 denotes protein
T1441 12202-12209 SO:0000104 denotes protein
T1442 12202-12209 GO:0003675 denotes protein
T1443 12278-12283 D055418 denotes BMP-6
T1444 12278-12283 D055418 denotes BMP-6
T1445 12278-12283 Q04906 denotes BMP-6
T1446 12278-12283 PR:000000167 denotes BMP-6
T1447 12278-12283 P20722 denotes BMP-6
T1448 12278-12283 PR:Q04906 denotes BMP-6
T1449 12278-12283 P22004 denotes BMP-6
T1450 12278-12283 PR:P22004 denotes BMP-6
T1451 12278-12283 PR:P20722 denotes BMP-6
T1452 12287-12295 C044203 denotes anti-IgM
T1453 12394-12399 D055418 denotes BMP-6
T1454 12394-12399 D055418 denotes BMP-6
T1455 12394-12399 Q04906 denotes BMP-6
T1456 12394-12399 PR:000000167 denotes BMP-6
T1457 12394-12399 P20722 denotes BMP-6
T1458 12394-12399 PR:Q04906 denotes BMP-6
T1459 12394-12399 P22004 denotes BMP-6
T1460 12394-12399 PR:P22004 denotes BMP-6
T1461 12394-12399 PR:P20722 denotes BMP-6
T1462 12456-12465 CHEBI:35222 denotes inhibitor
T1463 12467-12473 P97466 denotes Noggin
T1464 12467-12473 Q13253 denotes Noggin
T1465 12467-12473 Q9YHT8 denotes Noggin
T1466 12467-12473 PR:000000021 denotes Noggin
T1467 12467-12473 O93525 denotes Noggin
T1468 12467-12473 P49011 denotes Noggin
T1469 12467-12473 Q62809 denotes Noggin
T1470 12517-12523 P97466 denotes Noggin
T1471 12517-12523 Q13253 denotes Noggin
T1472 12517-12523 Q9YHT8 denotes Noggin
T1473 12517-12523 PR:000000021 denotes Noggin
T1474 12517-12523 O93525 denotes Noggin
T1475 12517-12523 P49011 denotes Noggin
T1476 12517-12523 Q62809 denotes Noggin
T1477 12542-12547 Q04906 denotes BMP-6
T1478 12542-12547 PR:000000167 denotes BMP-6
T1479 12542-12547 P20722 denotes BMP-6
T1480 12542-12547 PR:Q04906 denotes BMP-6
T1481 12542-12547 P22004 denotes BMP-6
T1482 12542-12547 PR:P22004 denotes BMP-6
T1483 12542-12547 PR:P20722 denotes BMP-6
T1484 12542-12547 D055418 denotes BMP-6
T1485 12542-12547 D055418 denotes BMP-6
T1486 12548-12558 CHEBI:48706 denotes antagonist
T1487 12600-12607 GO:0005625 denotes soluble
T1488 12608-12611 CHEBI:60815 denotes BMP
T1489 12608-12611 PR:000000034 denotes BMP
T1490 12608-12611 P35855 denotes BMP
T1491 12612-12615 CHEBI:33942 denotes RIB
T1492 12612-12615 UBERON:0002228 denotes RIB
T1493 12623-12626 CHEBI:60815 denotes BMP
T1494 12623-12626 PR:000000034 denotes BMP
T1495 12623-12626 P35855 denotes BMP
T1496 12634-12640 SO:0000806 denotes fusion
T1497 12641-12649 CHEBI:36080 denotes proteins
T1498 12700-12705 D055418 denotes BMP-6
T1499 12700-12705 D055418 denotes BMP-6
T1500 12700-12705 Q04906 denotes BMP-6
T1501 12700-12705 PR:000000167 denotes BMP-6
T1502 12700-12705 P20722 denotes BMP-6
T1503 12700-12705 PR:Q04906 denotes BMP-6
T1504 12700-12705 P22004 denotes BMP-6
T1505 12700-12705 PR:P22004 denotes BMP-6
T1506 12700-12705 PR:P20722 denotes BMP-6
T1507 12709-12714 D006801 denotes human
T1508 12886-12899 UBERON:2000098 denotes proliferation
T1509 12950-12955 UBERON:0002107 denotes liver
T1510 13017-13039 GO:0006915 denotes induction of apoptosis
T1511 13121-13126 D055418 denotes BMP-6
T1512 13121-13126 D055418 denotes BMP-6
T1513 13121-13126 Q04906 denotes BMP-6
T1514 13121-13126 PR:000000167 denotes BMP-6
T1515 13121-13126 P20722 denotes BMP-6
T1516 13121-13126 PR:Q04906 denotes BMP-6
T1517 13121-13126 P22004 denotes BMP-6
T1518 13121-13126 PR:P22004 denotes BMP-6
T1519 13121-13126 PR:P20722 denotes BMP-6
T1520 13127-13135 PR:P09486 denotes on human
T1521 13130-13135 D006801 denotes human
T1522 13188-13191 CHEBI:60815 denotes BMP
T1523 13188-13193 PR:P49001 denotes BMP-2
T1524 13188-13193 PR:P21274 denotes BMP-2
T1525 13188-13193 Q804S2 denotes BMP-2
T1526 13188-13193 P49001 denotes BMP-2
T1527 13188-13193 P12643 denotes BMP-2
T1528 13188-13193 P21274 denotes BMP-2
T1529 13188-13193 Q90751 denotes BMP-2
T1530 13188-13193 O46564 denotes BMP-2
T1531 13188-13193 PR:P12643 denotes BMP-2
T1532 13188-13193 PR:000000164 denotes BMP-2
T1533 13188-13193 O19006 denotes BMP-2
T1534 13210-13215 D006801 denotes human
T1535 13259-13262 CHEBI:60815 denotes BMP
T1536 13259-13262 PR:000000034 denotes BMP
T1537 13259-13262 P35855 denotes BMP
T1538 13304-13313 GO:0097194 denotes apoptosis
T1539 13304-13313 GO:0006915 denotes apoptosis
T1540 13328-13333 10090 denotes mouse
T1541 13328-13333 D051379 denotes mouse
T1542 13370-13373 CHEBI:60815 denotes BMP
T1543 13370-13375 O46576 denotes BMP-4
T1544 13370-13375 Q8MJV5 denotes BMP-4
T1545 13370-13375 PR:Q06826 denotes BMP-4
T1546 13370-13375 P12644 denotes BMP-4
T1547 13370-13375 PR:P12644 denotes BMP-4
T1548 13370-13375 P30885 denotes BMP-4
T1549 13370-13375 PR:000000165 denotes BMP-4
T1550 13370-13375 Q90752 denotes BMP-4
T1551 13370-13375 Q06826 denotes BMP-4
T1552 13370-13375 PR:P21275 denotes BMP-4
T1553 13370-13375 Q29607 denotes BMP-4
T1554 13370-13375 Q2KJH1 denotes BMP-4
T1555 13370-13375 P21275 denotes BMP-4
T1556 13385-13394 CL:0000893 denotes thymocyte
T1557 13385-13408 GO:0033080 denotes thymocyte proliferation
T1558 13395-13408 UBERON:2000098 denotes proliferation
T1559 13478-13488 GO:0065007 denotes regulation
T1560 13492-13505 UBERON:2000098 denotes proliferation
T1561 13510-13519 GO:0097194 denotes apoptosis
T1562 13510-13519 GO:0006915 denotes apoptosis
T1563 13566-13571 D055418 denotes BMP-6
T1564 13566-13571 D055418 denotes BMP-6
T1565 13566-13571 Q04906 denotes BMP-6
T1566 13566-13571 PR:000000167 denotes BMP-6
T1567 13566-13571 P20722 denotes BMP-6
T1568 13566-13571 PR:Q04906 denotes BMP-6
T1569 13566-13571 P22004 denotes BMP-6
T1570 13566-13571 PR:P22004 denotes BMP-6
T1571 13566-13571 PR:P20722 denotes BMP-6
T1572 13626-13629 PR:000000034 denotes BMP
T1573 13626-13629 P35855 denotes BMP
T1574 13626-13638 D052004 denotes BMP receptor
T1575 13676-13681 D006801 denotes Human
T1576 13727-13730 CHEBI:60815 denotes BMP
T1577 13727-13730 PR:000000034 denotes BMP
T1578 13727-13730 P35855 denotes BMP
T1579 13760-13763 CHEBI:60815 denotes BMP
T1580 13760-13763 PR:000000034 denotes BMP
T1581 13760-13763 P35855 denotes BMP
T1582 13764-13767 CHEBI:33942 denotes RIB
T1583 13764-13767 UBERON:0002228 denotes RIB
T1584 13785-13798 D052004 denotes receptors BMP
T1585 13795-13798 PR:000000034 denotes BMP
T1586 13795-13798 P35855 denotes BMP
T1587 13823-13829 SO:0000725 denotes signal
T1588 13823-13829 SO:0000418 denotes signal
T1589 13836-13843 SO:0100018 denotes binding
T1590 13836-13843 SO:0001091 denotes binding
T1591 13836-13843 GO:0005488 denotes binding
T1592 13871-13876 D055418 denotes BMP-6
T1593 13871-13876 D055418 denotes BMP-6
T1594 13871-13876 Q04906 denotes BMP-6
T1595 13871-13876 PR:000000167 denotes BMP-6
T1596 13871-13876 P20722 denotes BMP-6
T1597 13871-13876 PR:Q04906 denotes BMP-6
T1598 13871-13876 P22004 denotes BMP-6
T1599 13871-13876 PR:P22004 denotes BMP-6
T1600 13871-13876 PR:P20722 denotes BMP-6
T1601 13905-13910 D055418 denotes BMP-6
T1602 13905-13910 D055418 denotes BMP-6
T1603 13905-13910 Q04906 denotes BMP-6
T1604 13905-13910 PR:000000167 denotes BMP-6
T1605 13905-13910 P20722 denotes BMP-6
T1606 13905-13910 PR:Q04906 denotes BMP-6
T1607 13905-13910 P22004 denotes BMP-6
T1608 13905-13910 PR:P22004 denotes BMP-6
T1609 13905-13910 PR:P20722 denotes BMP-6
T1610 13919-13929 GO:0023052 denotes signalling
T1611 13985-14003 GO:0007165 denotes signalling pathway
T1612 13996-14003 CHEBI:34922 denotes pathway
T1613 14149-14164 GO:0016310 denotes phosphorylation
T1614 14197-14200 CHEBI:60815 denotes BMP
T1615 14197-14202 PR:P49001 denotes BMP-2
T1616 14197-14202 PR:P21274 denotes BMP-2
T1617 14197-14202 Q804S2 denotes BMP-2
T1618 14197-14202 P49001 denotes BMP-2
T1619 14197-14202 P12643 denotes BMP-2
T1620 14197-14202 P21274 denotes BMP-2
T1621 14197-14202 Q90751 denotes BMP-2
T1622 14197-14202 O46564 denotes BMP-2
T1623 14197-14202 PR:P12643 denotes BMP-2
T1624 14197-14202 PR:000000164 denotes BMP-2
T1625 14197-14202 O19006 denotes BMP-2
T1626 14242-14247 PR:000002089 denotes STAT3
T1627 14242-14247 PR:P42227 denotes STAT3
T1628 14242-14247 PR:Q6DV79 denotes STAT3
T1629 14242-14247 PR:P40763 denotes STAT3
T1630 14242-14247 PR:P52631 denotes STAT3
T1631 14279-14294 GO:0016310 denotes phosphorylation
T1632 14341-14344 CHEBI:60815 denotes BMP
T1633 14341-14346 PR:P49001 denotes BMP-2
T1634 14341-14346 PR:P21274 denotes BMP-2
T1635 14341-14346 Q804S2 denotes BMP-2
T1636 14341-14346 P49001 denotes BMP-2
T1637 14341-14346 P12643 denotes BMP-2
T1638 14341-14346 P21274 denotes BMP-2
T1639 14341-14346 Q90751 denotes BMP-2
T1640 14341-14346 O46564 denotes BMP-2
T1641 14341-14346 PR:P12643 denotes BMP-2
T1642 14341-14346 PR:000000164 denotes BMP-2
T1643 14341-14346 O19006 denotes BMP-2
T1644 14377-14392 GO:0016310 denotes phosphorylation
T1645 14396-14399 PR:000005882 denotes p38
T1646 14396-14399 O24473 denotes p38
T1647 14396-14399 P46108 denotes p38
T1648 14396-14399 Q64010 denotes p38
T1649 14396-14399 A0A0H3M950 denotes p38
T1650 14396-14399 P0C797 denotes p38
T1651 14396-14399 P04383 denotes p38
T1652 14396-14399 O95433 denotes p38
T1653 14396-14399 Q63768 denotes p38
T1654 14396-14399 PR:Q9LDA4 denotes p38
T1655 14396-14399 P06663 denotes p38
T1656 14396-14399 P0C796 denotes p38
T1657 14396-14399 PR:000003860 denotes p38
T1658 14396-14399 Q9NV58 denotes p38
T1659 14396-14399 O75791 denotes p38
T1660 14396-14399 PR:000008220 denotes p38
T1661 14396-14399 A0A0H3MBK5 denotes p38
T1662 14396-14399 P80350 denotes p38
T1663 14396-14399 PR:000012967 denotes p38
T1664 14396-14399 O97628 denotes p38
T1665 14396-14399 A0A0H3MBL5 denotes p38
T1666 14396-14399 Q9Y2S7 denotes p38
T1667 14396-14399 PR:000014113 denotes p38
T1668 14396-14399 P82869 denotes p38
T1669 14396-14399 Q9Q6X7 denotes p38
T1670 14396-14399 P9WGU1 denotes p38
T1671 14396-14399 Q04929 denotes p38
T1672 14412-14427 GO:0016310 denotes phosphorylation
T1673 14431-14434 PR:000005882 denotes p38
T1674 14431-14434 O24473 denotes p38
T1675 14431-14434 P46108 denotes p38
T1676 14431-14434 Q64010 denotes p38
T1677 14431-14434 A0A0H3M950 denotes p38
T1678 14431-14434 P0C797 denotes p38
T1679 14431-14434 P04383 denotes p38
T1680 14431-14434 O95433 denotes p38
T1681 14431-14434 Q63768 denotes p38
T1682 14431-14434 PR:Q9LDA4 denotes p38
T1683 14431-14434 P06663 denotes p38
T1684 14431-14434 P0C796 denotes p38
T1685 14431-14434 PR:000003860 denotes p38
T1686 14431-14434 Q9NV58 denotes p38
T1687 14431-14434 O75791 denotes p38
T1688 14431-14434 PR:000008220 denotes p38
T1689 14431-14434 A0A0H3MBK5 denotes p38
T1690 14431-14434 P80350 denotes p38
T1691 14431-14434 PR:000012967 denotes p38
T1692 14431-14434 O97628 denotes p38
T1693 14431-14434 A0A0H3MBL5 denotes p38
T1694 14431-14434 Q9Y2S7 denotes p38
T1695 14431-14434 PR:000014113 denotes p38
T1696 14431-14434 P82869 denotes p38
T1697 14431-14434 Q9Q6X7 denotes p38
T1698 14431-14434 P9WGU1 denotes p38
T1699 14431-14434 Q04929 denotes p38
T1700 14436-14441 PR:000002089 denotes STAT3
T1701 14436-14441 PR:P42227 denotes STAT3
T1702 14436-14441 PR:Q6DV79 denotes STAT3
T1703 14436-14441 PR:P40763 denotes STAT3
T1704 14436-14441 PR:P52631 denotes STAT3
T1705 14446-14451 PR:Q9I8V2 denotes Smad1
T1706 14446-14451 PR:P97588 denotes Smad1
T1707 14446-14451 Q15797 denotes Smad1
T1708 14446-14451 PR:000000363 denotes Smad1
T1709 14446-14451 PR:P70340 denotes Smad1
T1710 14446-14451 P70340 denotes Smad1
T1711 14446-14451 Q9I962 denotes Smad1
T1712 14446-14451 PR:Q15797 denotes Smad1
T1713 14446-14451 P97588 denotes Smad1
T1714 14446-14451 Q9I8V2 denotes Smad1
T1715 14446-14451 Q1JQA2 denotes Smad1
T1716 14476-14479 PR:000000034 denotes BMP
T1717 14476-14479 P35855 denotes BMP
T1718 14476-14479 CHEBI:60815 denotes BMP
T1719 14480-14490 GO:0023052 denotes signalling
T1720 14653-14658 D055418 denotes BMP-6
T1721 14653-14658 D055418 denotes BMP-6
T1722 14653-14658 Q04906 denotes BMP-6
T1723 14653-14658 PR:000000167 denotes BMP-6
T1724 14653-14658 P20722 denotes BMP-6
T1725 14653-14658 PR:Q04906 denotes BMP-6
T1726 14653-14658 P22004 denotes BMP-6
T1727 14653-14658 PR:P22004 denotes BMP-6
T1728 14653-14658 PR:P20722 denotes BMP-6
T1729 14682-14697 GO:0016310 denotes phosphorylation
T1730 14708-14713 PR:000002089 denotes STAT3
T1731 14708-14713 PR:P42227 denotes STAT3
T1732 14708-14713 PR:Q6DV79 denotes STAT3
T1733 14708-14713 PR:P40763 denotes STAT3
T1734 14708-14713 PR:P52631 denotes STAT3
T1735 14717-14720 PR:000005882 denotes p38
T1736 14717-14720 O24473 denotes p38
T1737 14717-14720 P46108 denotes p38
T1738 14717-14720 Q64010 denotes p38
T1739 14717-14720 A0A0H3M950 denotes p38
T1740 14717-14720 P0C797 denotes p38
T1741 14717-14720 P04383 denotes p38
T1742 14717-14720 O95433 denotes p38
T1743 14717-14720 Q63768 denotes p38
T1744 14717-14720 PR:Q9LDA4 denotes p38
T1745 14717-14720 P06663 denotes p38
T1746 14717-14720 P0C796 denotes p38
T1747 14717-14720 PR:000003860 denotes p38
T1748 14717-14720 Q9NV58 denotes p38
T1749 14717-14720 O75791 denotes p38
T1750 14717-14720 PR:000008220 denotes p38
T1751 14717-14720 A0A0H3MBK5 denotes p38
T1752 14717-14720 P80350 denotes p38
T1753 14717-14720 PR:000012967 denotes p38
T1754 14717-14720 O97628 denotes p38
T1755 14717-14720 A0A0H3MBL5 denotes p38
T1756 14717-14720 Q9Y2S7 denotes p38
T1757 14717-14720 PR:000014113 denotes p38
T1758 14717-14720 P82869 denotes p38
T1759 14717-14720 Q9Q6X7 denotes p38
T1760 14717-14720 P9WGU1 denotes p38
T1761 14717-14720 Q04929 denotes p38
T1762 14724-14729 D006801 denotes human
T1763 14778-14793 GO:0016310 denotes phosphorylation
T1764 14797-14802 PR:Q9I8V2 denotes Smad1
T1765 14797-14802 PR:P97588 denotes Smad1
T1766 14797-14802 Q15797 denotes Smad1
T1767 14797-14802 PR:000000363 denotes Smad1
T1768 14797-14802 PR:P70340 denotes Smad1
T1769 14797-14802 P70340 denotes Smad1
T1770 14797-14802 Q9I962 denotes Smad1
T1771 14797-14802 PR:Q15797 denotes Smad1
T1772 14797-14802 P97588 denotes Smad1
T1773 14797-14802 Q9I8V2 denotes Smad1
T1774 14797-14802 Q1JQA2 denotes Smad1
T1775 14885-14900 GO:0016310 denotes phosphorylation
T1776 14904-14909 PR:Q9I8V2 denotes Smad1
T1777 14904-14909 PR:P97588 denotes Smad1
T1778 14904-14909 Q15797 denotes Smad1
T1779 14904-14909 PR:000000363 denotes Smad1
T1780 14904-14909 PR:P70340 denotes Smad1
T1781 14904-14909 P70340 denotes Smad1
T1782 14904-14909 Q9I962 denotes Smad1
T1783 14904-14909 PR:Q15797 denotes Smad1
T1784 14904-14909 P97588 denotes Smad1
T1785 14904-14909 Q9I8V2 denotes Smad1
T1786 14904-14909 Q1JQA2 denotes Smad1
T1787 14942-14951 32644 denotes not shown
T1788 15015-15025 GO:0023052 denotes signalling
T1789 15073-15082 SO:0000119 denotes regulated
T1790 15106-15111 D006801 denotes human
T1791 15137-15140 PR:P41134 denotes Id1
T1792 15137-15140 PR:P20067 denotes Id1
T1793 15137-15140 PR:P41135 denotes Id1
T1794 15137-15140 PR:000000039 denotes Id1
T1795 15145-15150 PR:Q9I8V2 denotes Smad1
T1796 15145-15150 PR:P97588 denotes Smad1
T1797 15145-15150 Q15797 denotes Smad1
T1798 15145-15150 PR:000000363 denotes Smad1
T1799 15145-15150 PR:P70340 denotes Smad1
T1800 15145-15150 P70340 denotes Smad1
T1801 15145-15150 Q9I962 denotes Smad1
T1802 15145-15150 PR:Q15797 denotes Smad1
T1803 15145-15150 P97588 denotes Smad1
T1804 15145-15150 Q9I8V2 denotes Smad1
T1805 15145-15150 Q1JQA2 denotes Smad1
T1806 15155-15170 GO:0016310 denotes phosphorylation
T1807 15196-15201 Q04906 denotes BMP-6
T1808 15196-15201 PR:000000167 denotes BMP-6
T1809 15196-15201 P20722 denotes BMP-6
T1810 15196-15201 PR:Q04906 denotes BMP-6
T1811 15196-15201 P22004 denotes BMP-6
T1812 15196-15201 PR:P22004 denotes BMP-6
T1813 15196-15201 PR:P20722 denotes BMP-6
T1814 15196-15201 D055418 denotes BMP-6
T1815 15196-15201 D055418 denotes BMP-6
T1816 15202-15212 GO:0023052 denotes signalling
T1817 15247-15257 GO:0065007 denotes regulation
T1818 15264-15272 CHEBI:36080 denotes proteins
T1819 15322-15332 GO:0023052 denotes signalling
T1820 15374-15377 Q41249 denotes PCR
T1821 15374-15377 O66148 denotes PCR
T1822 15374-15377 Q59987 denotes PCR
T1823 15374-15377 Q01289 denotes PCR
T1824 15374-15377 O80333 denotes PCR
T1825 15374-15377 P15904 denotes PCR
T1826 15374-15377 Q9SDT1 denotes PCR
T1827 15374-15377 Q39617 denotes PCR
T1828 15415-15419 PR:000022679 denotes fold
T1829 15415-15419 PR:Q2FZJ6 denotes fold
T1830 15415-15419 PR:A5I112 denotes fold
T1831 15415-15419 PR:P24186 denotes fold
T1832 15437-15440 PR:P41134 denotes Id1
T1833 15437-15440 PR:P20067 denotes Id1
T1834 15437-15440 PR:P41135 denotes Id1
T1835 15437-15440 PR:000000039 denotes Id1
T1836 15444-15449 Q04906 denotes BMP-6
T1837 15444-15449 PR:000000167 denotes BMP-6
T1838 15444-15449 P20722 denotes BMP-6
T1839 15444-15449 PR:Q04906 denotes BMP-6
T1840 15444-15449 P22004 denotes BMP-6
T1841 15444-15449 PR:P22004 denotes BMP-6
T1842 15444-15449 PR:P20722 denotes BMP-6
T1843 15444-15449 D055418 denotes BMP-6
T1844 15444-15449 D055418 denotes BMP-6
T1845 15487-15490 PR:000000040 denotes Id2
T1846 15487-15490 PR:P41137 denotes Id2
T1847 15487-15490 PR:Q02363 denotes Id2
T1848 15487-15490 PR:P41136 denotes Id2
T1849 15487-15490 C039556 denotes Id2
T1850 15487-15490 C039556 denotes Id2
T1851 15491-15494 PR:P47928 denotes Id4
T1852 15491-15494 PR:P41139 denotes Id4
T1853 15491-15494 PR:000000042 denotes Id4
T1854 15593-15596 PR:P41134 denotes Id1
T1855 15593-15596 PR:P20067 denotes Id1
T1856 15593-15596 PR:P41135 denotes Id1
T1857 15593-15596 PR:000000039 denotes Id1
T1858 15597-15604 PR:000000001 denotes protein
T1859 15597-15604 GO:0003675 denotes protein
T1860 15597-15604 CHEBI:36080 denotes protein
T1861 15597-15604 CHEBI:11122 denotes protein
T1862 15597-15604 SO:0000104 denotes protein
T1863 15626-15629 PR:000000040 denotes Id2
T1864 15626-15629 PR:P41137 denotes Id2
T1865 15626-15629 PR:Q02363 denotes Id2
T1866 15626-15629 PR:P41136 denotes Id2
T1867 15626-15629 C039556 denotes Id2
T1868 15626-15629 C039556 denotes Id2
T1869 15634-15637 PR:P41133 denotes Id3
T1870 15634-15637 PR:P41138 denotes Id3
T1871 15634-15637 PR:Q02535 denotes Id3
T1872 15634-15637 PR:000000041 denotes Id3
T1873 15638-15645 PR:000000001 denotes protein
T1874 15638-15645 GO:0003675 denotes protein
T1875 15638-15645 CHEBI:36080 denotes protein
T1876 15638-15645 CHEBI:11122 denotes protein
T1877 15638-15645 SO:0000104 denotes protein
T1878 15685-15688 PR:P41134 denotes Id1
T1879 15685-15688 PR:P20067 denotes Id1
T1880 15685-15688 PR:P41135 denotes Id1
T1881 15685-15688 PR:000000039 denotes Id1
T1882 15764-15767 CVCL_N817 denotes pro
T1883 15764-15767 CHEBI:32871 denotes pro
T1884 15764-15767 CHEBI:32865 denotes pro
T1885 15764-15767 CHEBI:50342 denotes pro
T1886 15764-15767 CHEBI:32866 denotes pro
T1887 15764-15767 SO:0001439 denotes pro
T1888 15845-15850 10090 denotes mouse
T1889 15845-15850 D051379 denotes mouse
T1890 15851-15857 CL:0000236 denotes B cell
T1891 15851-15869 GO:0030183 denotes B cell development
T1892 15943-15946 PR:P41134 denotes Id1
T1893 15943-15946 PR:P20067 denotes Id1
T1894 15943-15946 PR:P41135 denotes Id1
T1895 15943-15946 PR:000000039 denotes Id1
T1896 15947-15951 D012333 denotes mRNA
T1897 15947-15951 CHEBI:33699 denotes mRNA
T1898 15947-15951 SO:0000234 denotes mRNA
T1899 15956-15963 PR:000000001 denotes protein
T1900 15956-15963 CHEBI:36080 denotes protein
T1901 15956-15963 CHEBI:11122 denotes protein
T1902 15956-15963 SO:0000104 denotes protein
T1903 15956-15963 GO:0003675 denotes protein
T1904 15981-15986 D006801 denotes human
T1905 16061-16066 PR:000000046 denotes TGF-β
T1906 16061-16066 D016212 denotes TGF-β
T1907 16061-16066 D016212 denotes TGF-β
T1908 16067-16077 GO:0023052 denotes signalling
T1909 16119-16122 PR:000000040 denotes Id2
T1910 16119-16122 PR:P41137 denotes Id2
T1911 16119-16122 PR:Q02363 denotes Id2
T1912 16119-16122 PR:P41136 denotes Id2
T1913 16119-16122 C039556 denotes Id2
T1914 16119-16122 C039556 denotes Id2
T1915 16127-16130 PR:P41133 denotes Id3
T1916 16127-16130 PR:P41138 denotes Id3
T1917 16127-16130 PR:Q02535 denotes Id3
T1918 16127-16130 PR:000000041 denotes Id3
T1919 16159-16162 PR:P41134 denotes Id1
T1920 16159-16162 PR:P20067 denotes Id1
T1921 16159-16162 PR:P41135 denotes Id1
T1922 16159-16162 PR:000000039 denotes Id1
T1923 16169-16178 32644 denotes not shown
T1924 16243-16248 PR:000000046 denotes TGF-β
T1925 16243-16248 D016212 denotes TGF-β
T1926 16243-16248 D016212 denotes TGF-β
T1927 16268-16276 CHEBI:36080 denotes proteins
T1928 16290-16293 PR:000000040 denotes Id2
T1929 16290-16293 PR:P41137 denotes Id2
T1930 16290-16293 PR:Q02363 denotes Id2
T1931 16290-16293 PR:P41136 denotes Id2
T1932 16290-16293 C039556 denotes Id2
T1933 16290-16293 C039556 denotes Id2
T1934 16298-16301 PR:P41133 denotes Id3
T1935 16298-16301 PR:P41138 denotes Id3
T1936 16298-16301 PR:Q02535 denotes Id3
T1937 16298-16301 PR:000000041 denotes Id3
T1938 16330-16338 CHEBI:36080 denotes proteins
T1939 16409-16412 PR:000000040 denotes Id2
T1940 16409-16412 PR:P41137 denotes Id2
T1941 16409-16412 PR:Q02363 denotes Id2
T1942 16409-16412 PR:P41136 denotes Id2
T1943 16409-16412 C039556 denotes Id2
T1944 16409-16412 C039556 denotes Id2
T1945 16417-16420 PR:P41133 denotes Id3
T1946 16417-16420 PR:P41138 denotes Id3
T1947 16417-16420 PR:Q02535 denotes Id3
T1948 16417-16420 PR:000000041 denotes Id3
T1949 16421-16428 PR:000000001 denotes protein
T1950 16421-16428 CHEBI:36080 denotes protein
T1951 16421-16428 CHEBI:11122 denotes protein
T1952 16421-16428 GO:0003675 denotes protein
T1953 16421-16428 SO:0000104 denotes protein
T1954 16473-16476 PR:P41134 denotes Id1
T1955 16473-16476 PR:P20067 denotes Id1
T1956 16473-16476 PR:P41135 denotes Id1
T1957 16473-16476 PR:000000039 denotes Id1
T1958 16506-16511 D055418 denotes BMP-6
T1959 16506-16511 D055418 denotes BMP-6
T1960 16506-16511 Q04906 denotes BMP-6
T1961 16506-16511 PR:000000167 denotes BMP-6
T1962 16506-16511 P20722 denotes BMP-6
T1963 16506-16511 PR:Q04906 denotes BMP-6
T1964 16506-16511 P22004 denotes BMP-6
T1965 16506-16511 PR:P22004 denotes BMP-6
T1966 16506-16511 PR:P20722 denotes BMP-6
T1967 16554-16561 CHEBI:36080 denotes protein
T1968 16554-16561 CHEBI:11122 denotes protein
T1969 16554-16561 PR:000000001 denotes protein
T1970 16554-16561 GO:0003675 denotes protein
T1971 16554-16561 SO:0000104 denotes protein
T1972 16576-16579 C039556 denotes Id2
T1973 16576-16579 C039556 denotes Id2
T1974 16576-16579 PR:000000040 denotes Id2
T1975 16576-16579 PR:P41137 denotes Id2
T1976 16576-16579 PR:Q02363 denotes Id2
T1977 16576-16579 PR:P41136 denotes Id2
T1978 16584-16587 PR:P41133 denotes Id3
T1979 16584-16587 PR:P41138 denotes Id3
T1980 16584-16587 PR:Q02535 denotes Id3
T1981 16584-16587 PR:000000041 denotes Id3
T1982 16612-16620 CHEBI:36080 denotes proteins
T1983 16655-16668 UBERON:2000098 denotes proliferation
T1984 16703-16711 CHEBI:36080 denotes proteins
T1985 16719-16736 SO:0002052 denotes dominant-negative
T1986 16737-16747 CHEBI:35222 denotes inhibitors
T1987 16753-16761 CHEBI:36080 denotes proteins
T1988 16766-16770 PR:Q02650 denotes Pax5
T1989 16766-16770 PR:000001903 denotes Pax5
T1990 16766-16770 PR:Q02548 denotes Pax5
T1991 16809-16817 CHEBI:36080 denotes proteins
T1992 16846-16849 CHEBI:16991 denotes DNA
T1993 16846-16849 D004247 denotes DNA
T1994 16846-16849 SO:0000352 denotes DNA
T1995 16846-16849 GO:0005574 denotes DNA
T1996 16897-16905 CHEBI:36080 denotes proteins
T1997 16907-16911 PR:Q02650 denotes Pax5
T1998 16907-16911 PR:000001903 denotes Pax5
T1999 16907-16911 PR:Q02548 denotes Pax5
T2000 16919-16927 CHEBI:36080 denotes proteins
T2001 17003-17011 CHEBI:36080 denotes proteins
T2002 17121-17131 CL:0000542 denotes lymphocyte
T2003 17121-17143 GO:0030098 denotes lymphocyte development
T2004 17201-17206 D055418 denotes BMP-6
T2005 17201-17206 D055418 denotes BMP-6
T2006 17201-17206 Q04906 denotes BMP-6
T2007 17201-17206 PR:000000167 denotes BMP-6
T2008 17201-17206 P20722 denotes BMP-6
T2009 17201-17206 PR:Q04906 denotes BMP-6
T2010 17201-17206 P22004 denotes BMP-6
T2011 17201-17206 PR:P22004 denotes BMP-6
T2012 17201-17206 PR:P20722 denotes BMP-6
T2013 17251-17254 PR:P41134 denotes Id1
T2014 17251-17254 PR:P20067 denotes Id1
T2015 17251-17254 PR:P41135 denotes Id1
T2016 17251-17254 PR:000000039 denotes Id1
T2017 17255-17262 CHEBI:36080 denotes protein
T2018 17255-17262 CHEBI:11122 denotes protein
T2019 17255-17262 PR:000000001 denotes protein
T2020 17255-17262 GO:0003675 denotes protein
T2021 17255-17262 SO:0000104 denotes protein
T2022 17306-17314 CHEBI:36080 denotes proteins
T2023 17367-17376 GO:0097194 denotes apoptosis
T2024 17367-17376 GO:0006915 denotes apoptosis
T2025 17380-17392 CL:0000236 denotes B-lymphocyte
T2026 17408-17413 D016212 denotes TGF-β
T2027 17408-17413 D016212 denotes TGF-β
T2028 17408-17413 PR:000000046 denotes TGF-β
T2029 17436-17444 CHEBI:36080 denotes proteins
T2030 17477-17487 GO:0023052 denotes signalling
T2031 17522-17532 GO:0007049 denotes cell cycle
T2032 17522-17532 UBERON:2000098 denotes cell cycle
T2033 17537-17550 D063646 denotes tumorigenesis
T2034 17537-17550 D063646 denotes tumorigenesis
T2035 17650-17655 D006801 denotes human
T2036 17679-17682 PR:P41134 denotes Id1
T2037 17679-17682 PR:P20067 denotes Id1
T2038 17679-17682 PR:P41135 denotes Id1
T2039 17679-17682 PR:000000039 denotes Id1
T2040 17757-17762 D006801 denotes human
T2041 17763-17775 D009369 denotes malignancies
T2042 17763-17775 D009369 denotes malignancies
T2043 17792-17808 D009101 denotes multiple myeloma
T2044 17792-17808 D009101 denotes multiple myeloma
T2045 17850-17855 D055418 denotes BMP-6
T2046 17850-17855 D055418 denotes BMP-6
T2047 17850-17855 Q04906 denotes BMP-6
T2048 17850-17855 PR:000000167 denotes BMP-6
T2049 17850-17855 P20722 denotes BMP-6
T2050 17850-17855 PR:Q04906 denotes BMP-6
T2051 17850-17855 P22004 denotes BMP-6
T2052 17850-17855 PR:P22004 denotes BMP-6
T2053 17850-17855 PR:P20722 denotes BMP-6
T2054 17866-17879 GO:0005622 denotes intracellular
T2055 17880-17890 GO:0023052 denotes signalling
T2056 17903-17908 D006801 denotes human
T2057 17974-17982 D008223 denotes lymphoma
T2058 17974-17982 D008223 denotes lymphoma
T2059 17987-17999 GO:0006954 denotes inflammation
T2060 17987-17999 D007249 denotes inflammation
T2061 17987-17999 D007249 denotes inflammation
T2062 18006-18011 D055418 denotes BMP-6
T2063 18006-18011 D055418 denotes BMP-6
T2064 18006-18011 Q04906 denotes BMP-6
T2065 18006-18011 PR:000000167 denotes BMP-6
T2066 18006-18011 P20722 denotes BMP-6
T2067 18006-18011 PR:Q04906 denotes BMP-6
T2068 18006-18011 P22004 denotes BMP-6
T2069 18006-18011 PR:P22004 denotes BMP-6
T2070 18006-18011 PR:P20722 denotes BMP-6
T2071 18012-18016 D012333 denotes mRNA
T2072 18012-18016 CHEBI:33699 denotes mRNA
T2073 18012-18016 SO:0000234 denotes mRNA
T2074 18158-18161 PR:P41134 denotes Id1
T2075 18158-18161 PR:P20067 denotes Id1
T2076 18158-18161 PR:P41135 denotes Id1
T2077 18158-18161 PR:000000039 denotes Id1
T2078 18162-18166 Q7SY53 denotes to B
T2079 18200-18206 CL:0000236 denotes B cell
T2080 18200-18218 GO:0030183 denotes B cell development
T2081 18228-18237 GO:0097194 denotes apoptosis
T2082 18228-18237 GO:0006915 denotes apoptosis
T2083 18269-18275 CL:0000236 denotes B cell
T2084 18269-18285 D016393 denotes B cell lymphomas
T2085 18269-18285 D016393 denotes B cell lymphomas
T2086 18302-18307 D055418 denotes BMP-6
T2087 18302-18307 D055418 denotes BMP-6
T2088 18302-18307 Q04906 denotes BMP-6
T2089 18302-18307 PR:000000167 denotes BMP-6
T2090 18302-18307 P20722 denotes BMP-6
T2091 18302-18307 PR:Q04906 denotes BMP-6
T2092 18302-18307 P22004 denotes BMP-6
T2093 18302-18307 PR:P22004 denotes BMP-6
T2094 18302-18307 PR:P20722 denotes BMP-6
T2095 18345-18365 D001172 denotes rheumatoid arthritis
T2096 18345-18365 D001172 denotes rheumatoid arthritis
T2097 18402-18405 PR:P41134 denotes Id1
T2098 18402-18405 PR:P20067 denotes Id1
T2099 18402-18405 PR:P41135 denotes Id1
T2100 18402-18405 PR:000000039 denotes Id1
T2101 18410-18413 PR:P41133 denotes Id3
T2102 18410-18413 PR:P41138 denotes Id3
T2103 18410-18413 PR:Q02535 denotes Id3
T2104 18410-18413 PR:000000041 denotes Id3
T2105 18526-18534 CHEBI:36080 denotes proteins
T2106 18542-18552 GO:0065007 denotes regulation
T2107 18563-18569 CL:0000236 denotes B cell
T2108 18563-18581 GO:0001782 denotes B cell homeostasis
T2109 18691-18695 PR:P41134 denotes Id-1
T2110 18691-18695 PR:P20067 denotes Id-1
T2111 18691-18695 PR:P41135 denotes Id-1
T2112 18691-18695 PR:000000039 denotes Id-1
T2113 18699-18704 D006801 denotes human
T2114 18759-18763 PR:P41134 denotes Id-1
T2115 18759-18763 PR:P20067 denotes Id-1
T2116 18759-18763 PR:P41135 denotes Id-1
T2117 18759-18763 PR:000000039 denotes Id-1
T2118 18764-18768 SO:0000704 denotes gene
T2119 18764-18779 GO:0010467 denotes gene expression
T2120 18799-18804 D055418 denotes BMP-6
T2121 18799-18804 D055418 denotes BMP-6
T2122 18799-18804 Q04906 denotes BMP-6
T2123 18799-18804 PR:000000167 denotes BMP-6
T2124 18799-18804 P20722 denotes BMP-6
T2125 18799-18804 PR:Q04906 denotes BMP-6
T2126 18799-18804 P22004 denotes BMP-6
T2127 18799-18804 PR:P22004 denotes BMP-6
T2128 18799-18804 PR:P20722 denotes BMP-6
T2129 18815-18820 D006801 denotes human
T2130 18866-18871 D055418 denotes BMP-6
T2131 18866-18871 D055418 denotes BMP-6
T2132 18866-18871 Q04906 denotes BMP-6
T2133 18866-18871 PR:000000167 denotes BMP-6
T2134 18866-18871 P20722 denotes BMP-6
T2135 18866-18871 PR:Q04906 denotes BMP-6
T2136 18866-18871 P22004 denotes BMP-6
T2137 18866-18871 PR:P22004 denotes BMP-6
T2138 18866-18871 PR:P20722 denotes BMP-6
T2139 18943-18949 GO:0007613 denotes memory
T2140 18999-19012 CL:0000785 denotes mature B cell
T2141 19027-19032 D055418 denotes BMP-6
T2142 19027-19032 D055418 denotes BMP-6
T2143 19027-19032 Q04906 denotes BMP-6
T2144 19027-19032 PR:000000167 denotes BMP-6
T2145 19027-19032 P20722 denotes BMP-6
T2146 19027-19032 PR:Q04906 denotes BMP-6
T2147 19027-19032 P22004 denotes BMP-6
T2148 19027-19032 PR:P22004 denotes BMP-6
T2149 19027-19032 PR:P20722 denotes BMP-6
T2150 19033-19037 D012333 denotes mRNA
T2151 19033-19037 CHEBI:33699 denotes mRNA
T2152 19033-19037 SO:0000234 denotes mRNA
T2153 19079-19083 SO:0000704 denotes gene
T2154 19079-19094 GO:0010467 denotes gene expression
T2155 19138-19143 D055418 denotes BMP-6
T2156 19138-19143 D055418 denotes BMP-6
T2157 19138-19143 Q04906 denotes BMP-6
T2158 19138-19143 PR:000000167 denotes BMP-6
T2159 19138-19143 P20722 denotes BMP-6
T2160 19138-19143 PR:Q04906 denotes BMP-6
T2161 19138-19143 P22004 denotes BMP-6
T2162 19138-19143 PR:P22004 denotes BMP-6
T2163 19138-19143 PR:P20722 denotes BMP-6
T2164 19238-19243 D055418 denotes BMP-6
T2165 19238-19243 D055418 denotes BMP-6
T2166 19238-19243 Q04906 denotes BMP-6
T2167 19238-19243 PR:000000167 denotes BMP-6
T2168 19238-19243 P20722 denotes BMP-6
T2169 19238-19243 PR:Q04906 denotes BMP-6
T2170 19238-19243 P22004 denotes BMP-6
T2171 19238-19243 PR:P22004 denotes BMP-6
T2172 19238-19243 PR:P20722 denotes BMP-6
T2173 19304-19311 UBERON:0000992 denotes ovarium
T2174 19389-19394 D055418 denotes BMP-6
T2175 19389-19394 D055418 denotes BMP-6
T2176 19389-19394 Q04906 denotes BMP-6
T2177 19389-19394 PR:000000167 denotes BMP-6
T2178 19389-19394 P20722 denotes BMP-6
T2179 19389-19394 PR:Q04906 denotes BMP-6
T2180 19389-19394 P22004 denotes BMP-6
T2181 19389-19394 PR:P22004 denotes BMP-6
T2182 19389-19394 PR:P20722 denotes BMP-6
T2183 19403-19408 D006801 denotes human
T2184 19445-19450 D055418 denotes BMP-6
T2185 19445-19450 D055418 denotes BMP-6
T2186 19445-19450 Q04906 denotes BMP-6
T2187 19445-19450 PR:000000167 denotes BMP-6
T2188 19445-19450 P20722 denotes BMP-6
T2189 19445-19450 PR:Q04906 denotes BMP-6
T2190 19445-19450 P22004 denotes BMP-6
T2191 19445-19450 PR:P22004 denotes BMP-6
T2192 19445-19450 PR:P20722 denotes BMP-6
T2193 19451-19455 D012333 denotes mRNA
T2194 19451-19455 CHEBI:33699 denotes mRNA
T2195 19451-19455 SO:0000234 denotes mRNA
T2196 19497-19500 Q41249 denotes PCR
T2197 19497-19500 O66148 denotes PCR
T2198 19497-19500 Q59987 denotes PCR
T2199 19497-19500 Q01289 denotes PCR
T2200 19497-19500 O80333 denotes PCR
T2201 19497-19500 P15904 denotes PCR
T2202 19497-19500 Q9SDT1 denotes PCR
T2203 19497-19500 Q39617 denotes PCR
T2204 19549-19554 D055418 denotes BMP-6
T2205 19549-19554 D055418 denotes BMP-6
T2206 19549-19554 Q04906 denotes BMP-6
T2207 19549-19554 PR:000000167 denotes BMP-6
T2208 19549-19554 P20722 denotes BMP-6
T2209 19549-19554 PR:Q04906 denotes BMP-6
T2210 19549-19554 P22004 denotes BMP-6
T2211 19549-19554 PR:P22004 denotes BMP-6
T2212 19549-19554 PR:P20722 denotes BMP-6
T2213 19595-19600 D006801 denotes human
T2214 19604-19609 UBERON:0001977 denotes serum
T2215 19633-19641 C044203 denotes anti-IgM
T2216 19674-19679 D055418 denotes BMP-6
T2217 19674-19679 D055418 denotes BMP-6
T2218 19674-19679 Q04906 denotes BMP-6
T2219 19674-19679 PR:000000167 denotes BMP-6
T2220 19674-19679 P20722 denotes BMP-6
T2221 19674-19679 PR:Q04906 denotes BMP-6
T2222 19674-19679 P22004 denotes BMP-6
T2223 19674-19679 PR:P22004 denotes BMP-6
T2224 19674-19679 PR:P20722 denotes BMP-6
T2225 19680-19687 CHEBI:36080 denotes protein
T2226 19680-19687 CHEBI:11122 denotes protein
T2227 19680-19687 PR:000000001 denotes protein
T2228 19680-19687 GO:0003675 denotes protein
T2229 19680-19687 SO:0000104 denotes protein
T2230 19745-19752 SO:0100018 denotes binding
T2231 19745-19752 SO:0001091 denotes binding
T2232 19745-19752 GO:0005488 denotes binding
T2233 19765-19770 D055418 denotes BMP-6
T2234 19765-19770 D055418 denotes BMP-6
T2235 19765-19770 Q04906 denotes BMP-6
T2236 19765-19770 PR:000000167 denotes BMP-6
T2237 19765-19770 P20722 denotes BMP-6
T2238 19765-19770 PR:Q04906 denotes BMP-6
T2239 19765-19770 P22004 denotes BMP-6
T2240 19765-19770 PR:P22004 denotes BMP-6
T2241 19765-19770 PR:P20722 denotes BMP-6
T2242 19771-19781 D000906 denotes antibodies
T2243 19794-19798 PR:Q9V853 denotes lack
T2244 19854-19859 D055418 denotes BMP-6
T2245 19854-19859 D055418 denotes BMP-6
T2246 19854-19859 Q04906 denotes BMP-6
T2247 19854-19859 PR:000000167 denotes BMP-6
T2248 19854-19859 P20722 denotes BMP-6
T2249 19854-19859 PR:Q04906 denotes BMP-6
T2250 19854-19859 P22004 denotes BMP-6
T2251 19854-19859 PR:P22004 denotes BMP-6
T2252 19854-19859 PR:P20722 denotes BMP-6
T2253 19860-19864 D012333 denotes mRNA
T2254 19860-19864 CHEBI:33699 denotes mRNA
T2255 19860-19864 SO:0000234 denotes mRNA
T2256 19895-19902 GO:0003675 denotes protein
T2257 19895-19902 CHEBI:36080 denotes protein
T2258 19895-19902 CHEBI:11122 denotes protein
T2259 19895-19902 PR:000000001 denotes protein
T2260 19895-19902 SO:0000104 denotes protein
T2261 19974-19979 D055418 denotes BMP-6
T2262 19974-19979 D055418 denotes BMP-6
T2263 19974-19979 Q04906 denotes BMP-6
T2264 19974-19979 PR:000000167 denotes BMP-6
T2265 19974-19979 P20722 denotes BMP-6
T2266 19974-19979 PR:Q04906 denotes BMP-6
T2267 19974-19979 P22004 denotes BMP-6
T2268 19974-19979 PR:P22004 denotes BMP-6
T2269 19974-19979 PR:P20722 denotes BMP-6
T2270 19980-19987 CHEBI:36080 denotes protein
T2271 19980-19987 CHEBI:11122 denotes protein
T2272 19980-19987 PR:000000001 denotes protein
T2273 19980-19987 GO:0003675 denotes protein
T2274 19980-19987 SO:0000104 denotes protein
T2275 20028-20034 UBERON:0000479 denotes tissue
T2276 20055-20060 D055418 denotes BMP-6
T2277 20055-20060 D055418 denotes BMP-6
T2278 20055-20060 Q04906 denotes BMP-6
T2279 20055-20060 PR:000000167 denotes BMP-6
T2280 20055-20060 P20722 denotes BMP-6
T2281 20055-20060 PR:Q04906 denotes BMP-6
T2282 20055-20060 P22004 denotes BMP-6
T2283 20055-20060 PR:P22004 denotes BMP-6
T2284 20055-20060 PR:P20722 denotes BMP-6
T2285 20075-20080 D006801 denotes human
T2286 20151-20156 D055418 denotes BMP-6
T2287 20151-20156 D055418 denotes BMP-6
T2288 20151-20156 Q04906 denotes BMP-6
T2289 20151-20156 PR:000000167 denotes BMP-6
T2290 20151-20156 P20722 denotes BMP-6
T2291 20151-20156 PR:Q04906 denotes BMP-6
T2292 20151-20156 P22004 denotes BMP-6
T2293 20151-20156 PR:P22004 denotes BMP-6
T2294 20151-20156 PR:P20722 denotes BMP-6
T2295 20160-20165 10090 denotes mouse
T2296 20160-20165 D051379 denotes mouse
T2297 20192-20203 UBERON:0002371 denotes bone marrow
T2298 20192-20203 D001855 denotes bone marrow
T2299 20192-20203 D001855 denotes bone marrow
T2300 20207-20211 PR:000005054 denotes mice
T2301 20207-20211 O89094 denotes mice
T2302 20207-20211 D051379 denotes mice
T2303 20207-20211 10095 denotes mice
T2304 20230-20239 D001168 denotes arthritis
T2305 20230-20239 D001168 denotes arthritis
T2306 20309-20318 D001168 denotes arthritis
T2307 20309-20318 D001168 denotes arthritis
T2308 20358-20363 D055418 denotes BMP-6
T2309 20358-20363 D055418 denotes BMP-6
T2310 20358-20363 Q04906 denotes BMP-6
T2311 20358-20363 PR:000000167 denotes BMP-6
T2312 20358-20363 P20722 denotes BMP-6
T2313 20358-20363 PR:Q04906 denotes BMP-6
T2314 20358-20363 P22004 denotes BMP-6
T2315 20358-20363 PR:P22004 denotes BMP-6
T2316 20358-20363 PR:P20722 denotes BMP-6
T2317 20382-20385 D007075 denotes IgM
T2318 20447-20452 PR:000000046 denotes TGF-β
T2319 20447-20452 D016212 denotes TGF-β
T2320 20447-20452 D016212 denotes TGF-β
T2321 20672-20686 D063646 denotes carcinogenesis
T2322 20672-20686 D063646 denotes carcinogenesis
T2323 20688-20693 D055418 denotes BMP-6
T2324 20688-20693 D055418 denotes BMP-6
T2325 20688-20693 Q04906 denotes BMP-6
T2326 20688-20693 PR:000000167 denotes BMP-6
T2327 20688-20693 P20722 denotes BMP-6
T2328 20688-20693 PR:Q04906 denotes BMP-6
T2329 20688-20693 P22004 denotes BMP-6
T2330 20688-20693 PR:P22004 denotes BMP-6
T2331 20688-20693 PR:P20722 denotes BMP-6
T2332 20710-20718 SO:0000167 denotes promoter
T2333 20844-20849 PR:000000046 denotes TGF-β
T2334 20844-20849 D016212 denotes TGF-β
T2335 20844-20849 D016212 denotes TGF-β
T2336 20876-20882 PR:000000182 denotes TGF-β1
T2337 20876-20882 D053773 denotes TGF-β1
T2338 20876-20882 D053773 denotes TGF-β1
T2339 20887-20890 CHEBI:60815 denotes BMP
T2340 20887-20892 O46576 denotes BMP-4
T2341 20887-20892 Q8MJV5 denotes BMP-4
T2342 20887-20892 PR:Q06826 denotes BMP-4
T2343 20887-20892 P12644 denotes BMP-4
T2344 20887-20892 PR:P12644 denotes BMP-4
T2345 20887-20892 P30885 denotes BMP-4
T2346 20887-20892 PR:000000165 denotes BMP-4
T2347 20887-20892 Q90752 denotes BMP-4
T2348 20887-20892 Q06826 denotes BMP-4
T2349 20887-20892 PR:P21275 denotes BMP-4
T2350 20887-20892 Q29607 denotes BMP-4
T2351 20887-20892 Q2KJH1 denotes BMP-4
T2352 20887-20892 P21275 denotes BMP-4
T2353 20939-20942 PR:000000034 denotes BMP
T2354 20939-20942 P35855 denotes BMP
T2355 20939-20942 CHEBI:60815 denotes BMP
T2356 21033-21038 D055418 denotes BMP-6
T2357 21033-21038 D055418 denotes BMP-6
T2358 21033-21038 Q04906 denotes BMP-6
T2359 21033-21038 PR:000000167 denotes BMP-6
T2360 21033-21038 P20722 denotes BMP-6
T2361 21033-21038 PR:Q04906 denotes BMP-6
T2362 21033-21038 P22004 denotes BMP-6
T2363 21033-21038 PR:P22004 denotes BMP-6
T2364 21033-21038 PR:P20722 denotes BMP-6
T2365 21039-21049 SO:0000673 denotes transcript
T2366 21089-21094 D055418 denotes BMP-6
T2367 21089-21094 D055418 denotes BMP-6
T2368 21089-21094 Q04906 denotes BMP-6
T2369 21089-21094 PR:000000167 denotes BMP-6
T2370 21089-21094 P20722 denotes BMP-6
T2371 21089-21094 PR:Q04906 denotes BMP-6
T2372 21089-21094 P22004 denotes BMP-6
T2373 21089-21094 PR:P22004 denotes BMP-6
T2374 21089-21094 PR:P20722 denotes BMP-6
T2375 21110-21115 D006801 denotes human
T2376 21133-21136 PR:000001004 denotes CD4
T2377 21133-21136 PR:P06332 denotes CD4
T2378 21133-21136 PR:P05540 denotes CD4
T2379 21133-21136 PR:P01730 denotes CD4
T2380 21200-21204 PR:P31041 denotes CD28
T2381 21200-21204 PR:P31043 denotes CD28
T2382 21200-21204 PR:P10747 denotes CD28
T2383 21200-21204 PR:000001841 denotes CD28
T2384 21200-21204 PR:P31042 denotes CD28
T2385 21211-21220 32644 denotes not shown
T2386 21255-21261 CL:0000084 denotes T cell
T2387 21288-21292 PR:000005054 denotes mice
T2388 21288-21292 O89094 denotes mice
T2389 21288-21292 D051379 denotes mice
T2390 21288-21292 10095 denotes mice
T2391 21315-21320 D055418 denotes BMP-6
T2392 21315-21320 D055418 denotes BMP-6
T2393 21315-21320 Q04906 denotes BMP-6
T2394 21315-21320 PR:000000167 denotes BMP-6
T2395 21315-21320 P20722 denotes BMP-6
T2396 21315-21320 PR:Q04906 denotes BMP-6
T2397 21315-21320 P22004 denotes BMP-6
T2398 21315-21320 PR:P22004 denotes BMP-6
T2399 21315-21320 PR:P20722 denotes BMP-6
T2400 21384-21397 D007154 denotes immune system
T2401 21384-21397 D007154 denotes immune system
T2402 21384-21397 UBERON:0002405 denotes immune system
T2403 21401-21407 UBERON:0000479 denotes tissue
T2404 21428-21448 UBERON:0002390 denotes hematopoietic system
T2405 21481-21486 D055418 denotes BMP-6
T2406 21481-21486 D055418 denotes BMP-6
T2407 21481-21486 Q04906 denotes BMP-6
T2408 21481-21486 PR:000000167 denotes BMP-6
T2409 21481-21486 P20722 denotes BMP-6
T2410 21481-21486 PR:Q04906 denotes BMP-6
T2411 21481-21486 P22004 denotes BMP-6
T2412 21481-21486 PR:P22004 denotes BMP-6
T2413 21481-21486 PR:P20722 denotes BMP-6
T2414 21505-21510 D006801 denotes human
T2415 21511-21515 UBERON:0001474 denotes bone
T2416 21511-21515 UBERON:0002481 denotes bone
T2417 21520-21531 D001855 denotes bone marrow
T2418 21520-21531 D001855 denotes bone marrow
T2419 21520-21538 UBERON:0007195 denotes bone marrow stroma
T2420 21582-21587 D006801 denotes human
T2421 21588-21602 UBERON:0002066 denotes umbilical vein
T2422 21622-21627 CVCL_2959 denotes HUVEC
T2423 21644-21649 D055418 denotes BMP-6
T2424 21644-21649 D055418 denotes BMP-6
T2425 21644-21649 Q04906 denotes BMP-6
T2426 21644-21649 PR:000000167 denotes BMP-6
T2427 21644-21649 P20722 denotes BMP-6
T2428 21644-21649 PR:Q04906 denotes BMP-6
T2429 21644-21649 P22004 denotes BMP-6
T2430 21644-21649 PR:P22004 denotes BMP-6
T2431 21644-21649 PR:P20722 denotes BMP-6
T2432 21650-21654 D012333 denotes mRNA
T2433 21650-21654 CHEBI:33699 denotes mRNA
T2434 21650-21654 SO:0000234 denotes mRNA
T2435 21674-21685 UBERON:0001986 denotes endothelium
T2436 21715-21720 D055418 denotes BMP-6
T2437 21715-21720 D055418 denotes BMP-6
T2438 21715-21720 Q04906 denotes BMP-6
T2439 21715-21720 PR:000000167 denotes BMP-6
T2440 21715-21720 P20722 denotes BMP-6
T2441 21715-21720 PR:Q04906 denotes BMP-6
T2442 21715-21720 P22004 denotes BMP-6
T2443 21715-21720 PR:P22004 denotes BMP-6
T2444 21715-21720 PR:P20722 denotes BMP-6
T2445 21764-21769 D055418 denotes BMP-6
T2446 21764-21769 D055418 denotes BMP-6
T2447 21764-21769 Q04906 denotes BMP-6
T2448 21764-21769 PR:000000167 denotes BMP-6
T2449 21764-21769 P20722 denotes BMP-6
T2450 21764-21769 PR:Q04906 denotes BMP-6
T2451 21764-21769 P22004 denotes BMP-6
T2452 21764-21769 PR:P22004 denotes BMP-6
T2453 21764-21769 PR:P20722 denotes BMP-6
T2454 21812-21817 D055418 denotes BMP-6
T2455 21812-21817 D055418 denotes BMP-6
T2456 21812-21817 Q04906 denotes BMP-6
T2457 21812-21817 PR:000000167 denotes BMP-6
T2458 21812-21817 P20722 denotes BMP-6
T2459 21812-21817 PR:Q04906 denotes BMP-6
T2460 21812-21817 P22004 denotes BMP-6
T2461 21812-21817 PR:P22004 denotes BMP-6
T2462 21812-21817 PR:P20722 denotes BMP-6
T2463 21818-21822 D012333 denotes mRNA
T2464 21818-21822 CHEBI:33699 denotes mRNA
T2465 21818-21822 SO:0000234 denotes mRNA
T2466 21855-21865 CL:0000235 denotes macrophage
T2467 21943-21948 D006801 denotes human
T2468 21963-21973 CL:0000775 denotes neutrophil
T2469 22038-22043 D055418 denotes BMP-6
T2470 22038-22043 D055418 denotes BMP-6
T2471 22038-22043 Q04906 denotes BMP-6
T2472 22038-22043 PR:000000167 denotes BMP-6
T2473 22038-22043 P20722 denotes BMP-6
T2474 22038-22043 PR:Q04906 denotes BMP-6
T2475 22038-22043 P22004 denotes BMP-6
T2476 22038-22043 PR:P22004 denotes BMP-6
T2477 22038-22043 PR:P20722 denotes BMP-6
T2478 22044-22054 SO:0000673 denotes transcript
T2479 22114-22119 D055418 denotes BMP-6
T2480 22114-22119 D055418 denotes BMP-6
T2481 22114-22119 Q04906 denotes BMP-6
T2482 22114-22119 PR:000000167 denotes BMP-6
T2483 22114-22119 P20722 denotes BMP-6
T2484 22114-22119 PR:Q04906 denotes BMP-6
T2485 22114-22119 P22004 denotes BMP-6
T2486 22114-22119 PR:P22004 denotes BMP-6
T2487 22114-22119 PR:P20722 denotes BMP-6
T2488 22134-22139 D006801 denotes human
T2489 22206-22211 D055418 denotes BMP-6
T2490 22206-22211 D055418 denotes BMP-6
T2491 22206-22211 Q04906 denotes BMP-6
T2492 22206-22211 PR:000000167 denotes BMP-6
T2493 22206-22211 P20722 denotes BMP-6
T2494 22206-22211 PR:Q04906 denotes BMP-6
T2495 22206-22211 P22004 denotes BMP-6
T2496 22206-22211 PR:P22004 denotes BMP-6
T2497 22206-22211 PR:P20722 denotes BMP-6
T2498 22234-22247 GO:0005622 denotes intracellular
T2499 22253-22263 GO:0023052 denotes signalling
T2500 22274-22279 D006801 denotes human
T2501 22319-22322 PR:P41134 denotes Id1
T2502 22319-22322 PR:P20067 denotes Id1
T2503 22319-22322 PR:P41135 denotes Id1
T2504 22319-22322 PR:000000039 denotes Id1
T2505 22323-22330 CHEBI:36080 denotes protein
T2506 22323-22330 CHEBI:11122 denotes protein
T2507 22323-22330 PR:000000001 denotes protein
T2508 22323-22330 GO:0003675 denotes protein
T2509 22323-22330 SO:0000104 denotes protein
T2510 22360-22365 D055418 denotes BMP-6
T2511 22360-22365 D055418 denotes BMP-6
T2512 22360-22365 Q04906 denotes BMP-6
T2513 22360-22365 PR:000000167 denotes BMP-6
T2514 22360-22365 P20722 denotes BMP-6
T2515 22360-22365 PR:Q04906 denotes BMP-6
T2516 22360-22365 P22004 denotes BMP-6
T2517 22360-22365 PR:P22004 denotes BMP-6
T2518 22360-22365 PR:P20722 denotes BMP-6
T2519 22425-22433 C044203 denotes anti-IgM
T2520 22466-22474 C044203 denotes anti-IgM
T2521 22479-22484 D023201 denotes CD40L
T2522 22479-22484 D023201 denotes CD40L
T2523 22479-22484 PR:P27548 denotes CD40L
T2524 22479-22484 PR:Q9I8D8 denotes CD40L
T2525 22479-22484 PR:000001950 denotes CD40L
T2526 22479-22484 PR:P29965 denotes CD40L
T2527 22479-22484 PR:Q9Z2V2 denotes CD40L
T2528 22479-22484 P27548 denotes CD40L
T2529 22479-22484 Q95MQ5 denotes CD40L
T2530 22479-22484 Q9BDM3 denotes CD40L
T2531 22479-22484 P63305 denotes CD40L
T2532 22479-22484 Q9BDM7 denotes CD40L
T2533 22479-22484 O97626 denotes CD40L
T2534 22479-22484 O97605 denotes CD40L
T2535 22479-22484 Q9Z2V2 denotes CD40L
T2536 22479-22484 P63304 denotes CD40L
T2537 22479-22484 Q9BDN3 denotes CD40L
T2538 22479-22484 Q9I8D8 denotes CD40L
T2539 22479-22484 P29965 denotes CD40L
T2540 22479-22484 P51749 denotes CD40L
T2541 22500-22505 D055418 denotes BMP-6
T2542 22500-22505 D055418 denotes BMP-6
T2543 22500-22505 Q04906 denotes BMP-6
T2544 22500-22505 PR:000000167 denotes BMP-6
T2545 22500-22505 P20722 denotes BMP-6
T2546 22500-22505 PR:Q04906 denotes BMP-6
T2547 22500-22505 P22004 denotes BMP-6
T2548 22500-22505 PR:P22004 denotes BMP-6
T2549 22500-22505 PR:P20722 denotes BMP-6
T2550 22514-22524 GO:0008219 denotes cell death
T2551 22538-22544 GO:0007613 denotes memory
T2552 22557-22562 CVCL_0597 denotes Ramos
T2553 22651-22656 D055418 denotes BMP-6
T2554 22651-22656 D055418 denotes BMP-6
T2555 22651-22656 Q04906 denotes BMP-6
T2556 22651-22656 PR:000000167 denotes BMP-6
T2557 22651-22656 P20722 denotes BMP-6
T2558 22651-22656 PR:Q04906 denotes BMP-6
T2559 22651-22656 P22004 denotes BMP-6
T2560 22651-22656 PR:P22004 denotes BMP-6
T2561 22651-22656 PR:P20722 denotes BMP-6
T2562 22657-22667 GO:0023052 denotes signalling
T2563 22678-22684 CL:0000236 denotes B cell
T2564 22734-22740 CL:0000236 denotes B cell
T2565 22741-22753 D009369 denotes malignancies
T2566 22741-22753 D009369 denotes malignancies
T2567 22806-22819 32644 denotes not specified
T2568 22893-22898 UBERON:0001977 denotes serum
T2569 22926-22929 CHEBI:29325 denotes CO2
T2570 22926-22929 CHEBI:48828 denotes CO2
T2571 22926-22929 CHEBI:16526 denotes CO2
T2572 22926-22929 CHEBI:29334 denotes CO2
T2573 23021-23027 CHEBI:48341 denotes formal
T2574 23126-23131 D006801 denotes human
T2575 23147-23151 PR:P25918 denotes CD19
T2576 23147-23151 PR:P15391 denotes CD19
T2577 23147-23151 PR:000001002 denotes CD19
T2578 23203-23212 GO:0020013 denotes rosetting
T2579 23457-23462 D006801 denotes human
T2580 23472-23484 D009369 denotes malignancies
T2581 23472-23484 D009369 denotes malignancies
T2582 23504-23508 PR:A5I6L6 denotes RPMI
T2583 23504-23508 PR:Q6HCV6 denotes RPMI
T2584 23504-23508 PR:A0KKP7 denotes RPMI
T2585 23504-23508 PR:P55874 denotes RPMI
T2586 23504-23508 PR:O88059 denotes RPMI
T2587 23504-23508 PR:Q5E5I4 denotes RPMI
T2588 23504-23508 PR:P66283 denotes RPMI
T2589 23504-23508 PR:P66279 denotes RPMI
T2590 23504-23508 PR:Q2FXQ0 denotes RPMI
T2591 23504-23508 PR:P66274 denotes RPMI
T2592 23504-23508 PR:P0A7Q1 denotes RPMI
T2593 23504-23508 PR:P66267 denotes RPMI
T2594 23504-23508 PR:Q32FI2 denotes RPMI
T2595 23504-23508 PR:P9WH91 denotes RPMI
T2596 23504-23508 PR:P66280 denotes RPMI
T2597 23504-23508 PR:Q89WH9 denotes RPMI
T2598 23504-23508 PR:Q6MU21 denotes RPMI
T2599 23504-23508 PR:Q817H6 denotes RPMI
T2600 23504-23508 PR:B7N554 denotes RPMI
T2601 23504-23508 PR:Q63TM4 denotes RPMI
T2602 23504-23508 PR:P0A7Q3 denotes RPMI
T2603 23504-23508 PR:Q8CS76 denotes RPMI
T2604 23504-23508 PR:Q8UIN8 denotes RPMI
T2605 23504-23508 PR:P0A163 denotes RPMI
T2606 23504-23508 PR:Q5F9U2 denotes RPMI
T2607 23504-23508 PR:Q038A1 denotes RPMI
T2608 23504-23508 PR:000023841 denotes RPMI
T2609 23504-23508 PR:B7NT60 denotes RPMI
T2610 23504-23508 PR:Q9I0A1 denotes RPMI
T2611 23504-23508 PR:Q62KI4 denotes RPMI
T2612 23504-23508 PR:Q8F6Q8 denotes RPMI
T2613 23504-23508 PR:P67917 denotes RPMI
T2614 23504-23508 PR:Q4ZUG5 denotes RPMI
T2615 23515-23518 586025 denotes PAA
T2616 23515-23518 342822 denotes PAA
T2617 23515-23518 UBERON:0004363 denotes PAA
T2618 23515-23518 CHEBI:51133 denotes PAA
T2619 23515-23518 CHEBI:61372 denotes PAA
T2620 23515-23518 GO:1990295 denotes PAA
T2621 23586-23592 9913 denotes bovine
T2622 23593-23598 UBERON:0001977 denotes serum
T2623 23619-23631 D010400 denotes penicillin G
T2624 23619-23631 D010400 denotes penicillin G
T2625 23619-23631 CHEBI:51354 denotes penicillin G
T2626 23619-23631 CHEBI:18208 denotes penicillin G
T2627 23619-23631 7980 denotes penicillin G
T2628 23653-23665 10109 denotes streptomycin
T2629 23653-23674 D013307 denotes streptomycin sulphate
T2630 23653-23674 D013307 denotes streptomycin sulphate
T2631 23680-23685 UBERON:0001977 denotes serum
T2632 23775-23778 D004854 denotes EBV
T2633 23802-23807 CVCL_0597 denotes Ramos
T2634 23826-23830 CVCL_0002 denotes HL60
T2635 23844-23858 D036341 denotes Growth factors
T2636 23844-23858 D036341 denotes Growth factors
T2637 23885-23893 CHEBI:33893 denotes reagents
T2638 23885-23893 D007202 denotes reagents
T2639 23945-23950 D006801 denotes human
T2640 23957-23962 D055418 denotes BMP-6
T2641 23957-23962 D055418 denotes BMP-6
T2642 23957-23962 Q04906 denotes BMP-6
T2643 23957-23962 PR:000000167 denotes BMP-6
T2644 23957-23962 P20722 denotes BMP-6
T2645 23957-23962 PR:Q04906 denotes BMP-6
T2646 23957-23962 P22004 denotes BMP-6
T2647 23957-23962 PR:P22004 denotes BMP-6
T2648 23957-23962 PR:P20722 denotes BMP-6
T2649 23976-23989 32644 denotes not specified
T2650 24006-24009 CHEBI:60815 denotes BMP
T2651 24006-24009 PR:000000034 denotes BMP
T2652 24006-24009 P35855 denotes BMP
T2653 24010-24013 CHEBI:33942 denotes RIB
T2654 24010-24013 UBERON:0002228 denotes RIB
T2655 24014-24019 PR:000000036 denotes ALK-6
T2656 24014-24019 Q05438 denotes ALK-6
T2657 24014-24019 P36898 denotes ALK-6
T2658 24023-24030 D002678 denotes Chimera
T2659 24023-24030 PR:000003507 denotes Chimera
T2660 24046-24053 Q13873 denotes BMPR-II
T2661 24046-24053 O35607 denotes BMPR-II
T2662 24046-24053 PR:000000037 denotes BMPR-II
T2663 24057-24064 D002678 denotes Chimera
T2664 24057-24064 PR:000003507 denotes Chimera
T2665 24092-24097 10090 denotes mouse
T2666 24092-24097 D051379 denotes mouse
T2667 24098-24104 P97466 denotes Noggin
T2668 24098-24104 Q13253 denotes Noggin
T2669 24098-24104 Q9YHT8 denotes Noggin
T2670 24098-24104 PR:000000021 denotes Noggin
T2671 24098-24104 O93525 denotes Noggin
T2672 24098-24104 P49011 denotes Noggin
T2673 24098-24104 Q62809 denotes Noggin
T2674 24163-24171 C044203 denotes Anti-IgM
T2675 24174-24178 CVCL_LJ79 denotes ab)2
T2676 24192-24198 D011817 denotes rabbit
T2677 24192-24198 9986 denotes rabbit
T2678 24192-24198 813859 denotes rabbit
T2679 24210-24220 D000906 denotes antibodies
T2680 24221-24229 PR:P48775 denotes to human
T2681 24224-24229 D006801 denotes human
T2682 24230-24233 D007075 denotes IgM
T2683 24234-24245 D006362 denotes heavy chain
T2684 24234-24245 D006362 denotes heavy chain
T2685 24240-24245 SO:0000419 denotes chain
T2686 24311-24322 D023201 denotes CD40 ligand
T2687 24311-24322 D023201 denotes CD40 ligand
T2688 24311-24322 P51749 denotes CD40 ligand
T2689 24311-24322 Q9BDM7 denotes CD40 ligand
T2690 24311-24322 Q9BDN3 denotes CD40 ligand
T2691 24311-24322 Q9I8D8 denotes CD40 ligand
T2692 24311-24322 P29965 denotes CD40 ligand
T2693 24311-24322 P63304 denotes CD40 ligand
T2694 24311-24322 O97626 denotes CD40 ligand
T2695 24311-24322 P27548 denotes CD40 ligand
T2696 24311-24322 O97605 denotes CD40 ligand
T2697 24311-24322 Q95MQ5 denotes CD40 ligand
T2698 24311-24322 Q9BDM3 denotes CD40 ligand
T2699 24311-24322 Q9Z2V2 denotes CD40 ligand
T2700 24311-24322 P63305 denotes CD40 ligand
T2701 24316-24322 GO:0005488 denotes ligand
T2702 24324-24329 D023201 denotes CD40L
T2703 24324-24329 D023201 denotes CD40L
T2704 24324-24329 PR:P27548 denotes CD40L
T2705 24324-24329 PR:Q9I8D8 denotes CD40L
T2706 24324-24329 PR:000001950 denotes CD40L
T2707 24324-24329 PR:P29965 denotes CD40L
T2708 24324-24329 PR:Q9Z2V2 denotes CD40L
T2709 24324-24329 P27548 denotes CD40L
T2710 24324-24329 Q95MQ5 denotes CD40L
T2711 24324-24329 Q9BDM3 denotes CD40L
T2712 24324-24329 P63305 denotes CD40L
T2713 24324-24329 Q9BDM7 denotes CD40L
T2714 24324-24329 O97626 denotes CD40L
T2715 24324-24329 O97605 denotes CD40L
T2716 24324-24329 Q9Z2V2 denotes CD40L
T2717 24324-24329 P63304 denotes CD40L
T2718 24324-24329 Q9BDN3 denotes CD40L
T2719 24324-24329 Q9I8D8 denotes CD40L
T2720 24324-24329 P29965 denotes CD40L
T2721 24324-24329 P51749 denotes CD40L
T2722 24328-24333 PR:Q6PL24 denotes L, 10
T2723 24328-24333 PR:000016405 denotes L, 10
T2724 24328-24333 P51417 denotes L, 10
T2725 24328-24333 CVCL_XK53 denotes L, 10
T2726 24387-24397 D000906 denotes Antibodies
T2727 24456-24466 D000906 denotes Antibodies
T2728 24479-24484 D006801 denotes human
T2729 24485-24488 PR:000000034 denotes BMP
T2730 24485-24488 P35855 denotes BMP
T2731 24485-24498 D052004 denotes BMP-receptors
T2732 24508-24511 CHEBI:60815 denotes BMP
T2733 24508-24511 PR:000000034 denotes BMP
T2734 24508-24511 P35855 denotes BMP
T2735 24512-24515 CHEBI:33942 denotes RIB
T2736 24512-24515 UBERON:0002228 denotes RIB
T2737 24517-24524 Q13873 denotes BMPR-II
T2738 24517-24524 O35607 denotes BMPR-II
T2739 24517-24524 PR:000000037 denotes BMPR-II
T2740 24615-24620 D055418 denotes BMP-6
T2741 24615-24620 D055418 denotes BMP-6
T2742 24615-24620 Q04906 denotes BMP-6
T2743 24615-24620 PR:000000167 denotes BMP-6
T2744 24615-24620 P20722 denotes BMP-6
T2745 24615-24620 PR:Q04906 denotes BMP-6
T2746 24615-24620 P22004 denotes BMP-6
T2747 24615-24620 PR:P22004 denotes BMP-6
T2748 24615-24620 PR:P20722 denotes BMP-6
T2749 24621-24628 CHEBI:36080 denotes protein
T2750 24621-24628 CHEBI:11122 denotes protein
T2751 24621-24628 PR:000000001 denotes protein
T2752 24621-24628 GO:0003675 denotes protein
T2753 24621-24628 SO:0000104 denotes protein
T2754 24663-24673 D000906 denotes antibodies
T2755 24675-24679 PR:Q96T53 denotes goat
T2756 24675-24679 PR:B1Q006 denotes goat
T2757 24675-24679 PR:000010226 denotes goat
T2758 24675-24679 PR:B1Q005 denotes goat
T2759 24675-24679 PR:P0C7A3 denotes goat
T2760 24675-24679 9925 denotes goat
T2761 24675-24679 D006041 denotes goat
T2762 24696-24701 D055418 denotes BMP-6
T2763 24696-24701 D055418 denotes BMP-6
T2764 24696-24701 Q04906 denotes BMP-6
T2765 24696-24701 PR:000000167 denotes BMP-6
T2766 24696-24701 P20722 denotes BMP-6
T2767 24696-24701 PR:Q04906 denotes BMP-6
T2768 24696-24701 P22004 denotes BMP-6
T2769 24696-24701 PR:P22004 denotes BMP-6
T2770 24696-24701 PR:P20722 denotes BMP-6
T2771 24703-24708 F1REV3 denotes Santa
T2772 24747-24752 10090 denotes mouse
T2773 24747-24752 D051379 denotes mouse
T2774 24758-24763 D055418 denotes BMP-6
T2775 24758-24763 D055418 denotes BMP-6
T2776 24758-24763 Q04906 denotes BMP-6
T2777 24758-24763 PR:000000167 denotes BMP-6
T2778 24758-24763 P20722 denotes BMP-6
T2779 24758-24763 PR:Q04906 denotes BMP-6
T2780 24758-24763 P22004 denotes BMP-6
T2781 24758-24763 PR:P22004 denotes BMP-6
T2782 24758-24763 PR:P20722 denotes BMP-6
T2783 24779-24783 PR:Q96T53 denotes goat
T2784 24779-24783 PR:B1Q006 denotes goat
T2785 24779-24783 PR:000010226 denotes goat
T2786 24779-24783 PR:B1Q005 denotes goat
T2787 24779-24783 PR:P0C7A3 denotes goat
T2788 24779-24783 9925 denotes goat
T2789 24779-24783 D006041 denotes goat
T2790 24789-24794 D055418 denotes BMP-6
T2791 24789-24794 D055418 denotes BMP-6
T2792 24789-24794 Q04906 denotes BMP-6
T2793 24789-24794 PR:000000167 denotes BMP-6
T2794 24789-24794 P20722 denotes BMP-6
T2795 24789-24794 PR:Q04906 denotes BMP-6
T2796 24789-24794 P22004 denotes BMP-6
T2797 24789-24794 PR:P22004 denotes BMP-6
T2798 24789-24794 PR:P20722 denotes BMP-6
T2799 24834-24839 10090 denotes mouse
T2800 24834-24839 D051379 denotes mouse
T2801 24856-24861 D055418 denotes BMP-6
T2802 24856-24861 D055418 denotes BMP-6
T2803 24856-24861 Q04906 denotes BMP-6
T2804 24856-24861 PR:000000167 denotes BMP-6
T2805 24856-24861 P20722 denotes BMP-6
T2806 24856-24861 PR:Q04906 denotes BMP-6
T2807 24856-24861 P22004 denotes BMP-6
T2808 24856-24861 PR:P22004 denotes BMP-6
T2809 24856-24861 PR:P20722 denotes BMP-6
T2810 24886-24889 UBERON:0035973 denotes Inc
T2811 24931-24934 CHEBI:60815 denotes BMP
T2812 24931-24934 PR:000000034 denotes BMP
T2813 24931-24934 P35855 denotes BMP
T2814 24935-24945 GO:0023052 denotes signalling
T2815 24979-24986 CHEBI:48108 denotes phospho
T2816 24987-24992 PR:Q9I8V2 denotes Smad1
T2817 24987-24992 PR:P97588 denotes Smad1
T2818 24987-24992 Q15797 denotes Smad1
T2819 24987-24992 PR:000000363 denotes Smad1
T2820 24987-24992 PR:P70340 denotes Smad1
T2821 24987-24992 P70340 denotes Smad1
T2822 24987-24992 Q9I962 denotes Smad1
T2823 24987-24992 PR:Q15797 denotes Smad1
T2824 24987-24992 P97588 denotes Smad1
T2825 24987-24992 Q9I8V2 denotes Smad1
T2826 24987-24992 Q1JQA2 denotes Smad1
T2827 25016-25024 GO:0019815 denotes antibody
T2828 25016-25024 GO:0042571 denotes antibody
T2829 25016-25024 GO:0019814 denotes antibody
T2830 25016-25024 GO:0003823 denotes antibody
T2831 25077-25080 PR:P41134 denotes Id1
T2832 25077-25080 PR:P20067 denotes Id1
T2833 25077-25080 PR:P41135 denotes Id1
T2834 25077-25080 PR:000000039 denotes Id1
T2835 25083-25091 CHEBI:36080 denotes proteins
T2836 25122-25128 D011817 denotes rabbit
T2837 25122-25128 9986 denotes rabbit
T2838 25122-25128 813859 denotes rabbit
T2839 25129-25137 GO:0019815 denotes antibody
T2840 25129-25137 GO:0042571 denotes antibody
T2841 25129-25137 GO:0019814 denotes antibody
T2842 25129-25137 GO:0003823 denotes antibody
T2843 25178-25185 PR:000018264 denotes peptide
T2844 25178-25185 PR:000018263 denotes peptide
T2845 25178-25185 CHEBI:16670 denotes peptide
T2846 25178-25185 SO:0001064 denotes peptide
T2847 25191-25196 F1REV3 denotes Santa
T2848 25217-25222 F1REV3 denotes Santa
T2849 25263-25273 D000906 denotes antibodies
T2850 25286-25291 10090 denotes mouse
T2851 25286-25291 D051379 denotes mouse
T2852 25298-25302 9925 denotes goat
T2853 25298-25302 D006041 denotes goat
T2854 25298-25302 PR:Q96T53 denotes goat
T2855 25298-25302 PR:B1Q006 denotes goat
T2856 25298-25302 PR:000010226 denotes goat
T2857 25298-25302 PR:B1Q005 denotes goat
T2858 25298-25302 PR:P0C7A3 denotes goat
T2859 25311-25317 D011817 denotes rabbit
T2860 25311-25317 9986 denotes rabbit
T2861 25311-25317 813859 denotes rabbit
T2862 25318-25345 C051538 denotes IgG- horseradish peroxidase
T2863 25323-25334 3704 denotes horseradish
T2864 25323-25334 D031215 denotes horseradish
T2865 25323-25334 1011043 denotes horseradish
T2866 25323-25350 GO:0004601 denotes horseradish peroxidase (HRP
T2867 25335-25345 P15984 denotes peroxidase
T2868 25335-25345 Q9SCX8 denotes peroxidase
T2869 25335-25345 P85957 denotes peroxidase
T2870 25335-25345 Q01603 denotes peroxidase
T2871 25335-25345 Q55080 denotes peroxidase
T2872 25335-25345 P85317 denotes peroxidase
T2873 25335-25345 Q05855 denotes peroxidase
T2874 25335-25345 A8NK72 denotes peroxidase
T2875 25335-25345 P84714 denotes peroxidase
T2876 25335-25345 P28313 denotes peroxidase
T2877 25335-25345 P28314 denotes peroxidase
T2878 25335-25345 P16147 denotes peroxidase
T2879 25335-25345 B3EWG7 denotes peroxidase
T2880 25335-25345 1600930 denotes peroxidase
T2881 25347-25350 PR:Q0V967 denotes HRP
T2882 25347-25350 Q08168 denotes HRP
T2883 25427-25434 O42161 denotes β-actin
T2884 25427-25434 Q5R1X3 denotes β-actin
T2885 25427-25434 Q9Y702 denotes β-actin
T2886 25427-25434 P60706 denotes β-actin
T2887 25427-25434 P29751 denotes β-actin
T2888 25427-25434 P68143 denotes β-actin
T2889 25427-25434 P83750 denotes β-actin
T2890 25427-25434 P60710 denotes β-actin
T2891 25427-25434 Q71FK5 denotes β-actin
T2892 25427-25434 P60711 denotes β-actin
T2893 25427-25434 Q76N69 denotes β-actin
T2894 25427-25434 P79818 denotes β-actin
T2895 25427-25434 P60713 denotes β-actin
T2896 25427-25434 PR:000003676 denotes β-actin
T2897 25427-25434 Q0PGG4 denotes β-actin
T2898 25427-25434 Q6QAQ1 denotes β-actin
T2899 25427-25434 P84336 denotes β-actin
T2900 25427-25434 O93400 denotes β-actin
T2901 25427-25434 Q711N9 denotes β-actin
T2902 25427-25434 O18840 denotes β-actin
T2903 25427-25434 P48975 denotes β-actin
T2904 25427-25434 Q4L0Y2 denotes β-actin
T2905 25427-25434 Q5R6G0 denotes β-actin
T2906 25427-25434 P83751 denotes β-actin
T2907 25427-25434 P60707 denotes β-actin
T2908 25427-25434 P60709 denotes β-actin
T2909 25427-25434 P60712 denotes β-actin
T2910 25427-25434 Q91ZK5 denotes β-actin
T2911 25427-25434 P15475 denotes β-actin
T2912 25427-25434 Q6NVA9 denotes β-actin
T2913 25427-25434 P84856 denotes β-actin
T2914 25427-25434 Q4R561 denotes β-actin
T2915 25427-25434 P60708 denotes β-actin
T2916 25427-25434 D000199 denotes β-actin
T2917 25444-25449 F1REV3 denotes Santa
T2918 25512-25516 PR:P25918 denotes CD19
T2919 25512-25516 PR:P15391 denotes CD19
T2920 25512-25516 PR:000001002 denotes CD19
T2921 25526-25530 PR:P25918 denotes CD19
T2922 25526-25530 PR:P15391 denotes CD19
T2923 25526-25530 PR:000001002 denotes CD19
T2924 25531-25535 CHEBI:37926 denotes FITC
T2925 25531-25535 D016650 denotes FITC
T2926 25531-25535 D016650 denotes FITC
T2927 25541-25551 D000906 denotes antibodies
T2928 25584-25588 PR:P25918 denotes CD19
T2929 25584-25588 PR:P15391 denotes CD19
T2930 25584-25588 PR:000001002 denotes CD19
T2931 25589-25592 C075359 denotes PC5
T2932 25589-25592 C075359 denotes PC5
T2933 25589-25592 Q92824 denotes PC5
T2934 25589-25592 Q04592 denotes PC5
T2935 25589-25592 PR:000012437 denotes PC5
T2936 25589-25592 P41413 denotes PC5
T2937 25589-25592 PR:Q92824 denotes PC5
T2938 25589-25592 CVCL_M124 denotes PC5
T2939 25641-25645 PR:P41272 denotes CD27
T2940 25641-25645 PR:000001963 denotes CD27
T2941 25641-25645 PR:P26842 denotes CD27
T2942 25747-25751 PR:P25918 denotes CD19
T2943 25747-25751 PR:P15391 denotes CD19
T2944 25747-25751 PR:000001002 denotes CD19
T2945 25752-25756 PR:P41272 denotes CD27
T2946 25752-25756 PR:000001963 denotes CD27
T2947 25752-25756 PR:P26842 denotes CD27
T2948 25761-25765 PR:P25918 denotes CD19
T2949 25761-25765 PR:P15391 denotes CD19
T2950 25761-25765 PR:000001002 denotes CD19
T2951 25766-25770 PR:P41272 denotes CD27
T2952 25766-25770 PR:000001963 denotes CD27
T2953 25766-25770 PR:P26842 denotes CD27
T2954 25804-25808 PR:P25918 denotes CD19
T2955 25804-25808 PR:P15391 denotes CD19
T2956 25804-25808 PR:000001002 denotes CD19
T2957 25826-25830 PR:P41272 denotes CD27
T2958 25826-25830 PR:000001963 denotes CD27
T2959 25826-25830 PR:P26842 denotes CD27
T2960 25838-25842 PR:P25918 denotes CD19
T2961 25838-25842 PR:P15391 denotes CD19
T2962 25838-25842 PR:000001002 denotes CD19
T2963 25843-25846 Q92824 denotes PC5
T2964 25843-25846 Q04592 denotes PC5
T2965 25843-25846 PR:000012437 denotes PC5
T2966 25843-25846 P41413 denotes PC5
T2967 25843-25846 PR:Q92824 denotes PC5
T2968 25843-25846 C075359 denotes PC5
T2969 25843-25846 C075359 denotes PC5
T2970 25843-25846 CVCL_M124 denotes PC5
T2971 25900-25903 D011535 denotes PBS
T2972 25919-25923 P9WQ36 denotes FACS
T2973 25919-25923 P9WQ37 denotes FACS
T2974 25924-25928 PR:Q9Z0F3 denotes DiVa
T2975 25924-25928 PR:P0ABH0 denotes DiVa
T2976 25924-25928 PR:000022714 denotes DiVa
T2977 25924-25928 PR:000004693 denotes DiVa
T2978 26008-26021 CL:0000010 denotes cultured cell
T2979 26042-26047 GO:0019835 denotes lysis
T2980 26048-26054 CHEBI:35225 denotes buffer
T2981 26056-26064 D005990 denotes glycerol
T2982 26056-26064 CHEBI:17754 denotes glycerol
T2983 26056-26064 D005990 denotes glycerol
T2984 26070-26087 CHEBI:41218 denotes β-mercaptoethanol
T2985 26101-26105 CHEBI:9754 denotes Tris
T2986 26101-26105 PR:Q9NQV6 denotes Tris
T2987 26101-26105 PR:000013180 denotes Tris
T2988 26101-26105 PR:Q3UTQ7 denotes Tris
T2989 26106-26109 CHEBI:17883 denotes HCL
T2990 26111-26115 CVCL_UA31 denotes pH 6
T2991 26120-26143 CHEBI:8984 denotes sodium dodecyl sulphate
T2992 26145-26148 CHEBI:8984 denotes SDS
T2993 26145-26148 PR:000014570 denotes SDS
T2994 26145-26148 B5HDJ6 denotes SDS
T2995 26145-26148 PR:000014571 denotes SDS
T2996 26145-26148 PR:P09367 denotes SDS
T2997 26145-26148 PR:P20132 denotes SDS
T2998 26145-26148 PR:Q8R238 denotes SDS
T2999 26145-26148 PR:Q8VBT2 denotes SDS
T3000 26145-26148 PR:Q86B06 denotes SDS
T3001 26145-26148 PR:Q1PFW3 denotes SDS
T3002 26145-26148 D000081003 denotes SDS
T3003 26168-26175 GO:0003675 denotes protein
T3004 26168-26175 CHEBI:36080 denotes protein
T3005 26168-26175 CHEBI:11122 denotes protein
T3006 26168-26175 PR:000000001 denotes protein
T3007 26168-26175 SO:0000104 denotes protein
T3008 26227-26230 CHEBI:8984 denotes SDS
T3009 26227-26230 PR:000014570 denotes SDS
T3010 26227-26230 B5HDJ6 denotes SDS
T3011 26227-26230 PR:000014571 denotes SDS
T3012 26227-26230 PR:P09367 denotes SDS
T3013 26227-26230 PR:P20132 denotes SDS
T3014 26227-26230 PR:Q8R238 denotes SDS
T3015 26227-26230 PR:Q8VBT2 denotes SDS
T3016 26227-26230 PR:Q86B06 denotes SDS
T3017 26227-26230 PR:Q1PFW3 denotes SDS
T3018 26227-26230 D000081003 denotes SDS
T3019 26231-26245 CHEBI:51135 denotes polyacrylamide
T3020 26231-26245 CHEBI:53656 denotes polyacrylamide
T3021 26231-26245 C016679 denotes polyacrylamide
T3022 26231-26245 CHEBI:60766 denotes polyacrylamide
T3023 26247-26250 CHEBI:8984 denotes SDS
T3024 26247-26250 PR:000014570 denotes SDS
T3025 26247-26250 B5HDJ6 denotes SDS
T3026 26247-26250 PR:000014571 denotes SDS
T3027 26247-26250 PR:P09367 denotes SDS
T3028 26247-26250 PR:P20132 denotes SDS
T3029 26247-26250 PR:Q8R238 denotes SDS
T3030 26247-26250 PR:Q8VBT2 denotes SDS
T3031 26247-26250 PR:Q86B06 denotes SDS
T3032 26247-26250 PR:Q1PFW3 denotes SDS
T3033 26247-26250 D000081003 denotes SDS
T3034 26257-26261 D005782 denotes gels
T3035 26257-26261 D005782 denotes gels
T3036 26279-26293 CHEBI:53325 denotes nitrocellulose
T3037 26279-26293 D003101 denotes nitrocellulose
T3038 26279-26293 1425879 denotes nitrocellulose
T3039 26417-26427 D000906 denotes antibodies
T3040 26525-26528 CHEBI:127105 denotes TBS
T3041 26534-26542 CHEBI:9784 denotes Tween-20
T3042 26534-26542 D011136 denotes Tween-20
T3043 26534-26542 D011136 denotes Tween-20
T3044 26534-26542 CHEBI:53424 denotes Tween-20
T3045 26544-26547 CHEBI:127105 denotes TBS
T3046 26584-26595 3704 denotes horseradish
T3047 26584-26595 D031215 denotes horseradish
T3048 26584-26595 1011043 denotes horseradish
T3049 26584-26606 D006735 denotes horseradish peroxidase
T3050 26584-26611 GO:0004601 denotes horseradish peroxidase (HRP
T3051 26596-26606 1600930 denotes peroxidase
T3052 26596-26606 P15984 denotes peroxidase
T3053 26596-26606 Q9SCX8 denotes peroxidase
T3054 26596-26606 P85957 denotes peroxidase
T3055 26596-26606 Q01603 denotes peroxidase
T3056 26596-26606 Q55080 denotes peroxidase
T3057 26596-26606 P85317 denotes peroxidase
T3058 26596-26606 Q05855 denotes peroxidase
T3059 26596-26606 A8NK72 denotes peroxidase
T3060 26596-26606 P84714 denotes peroxidase
T3061 26596-26606 P28313 denotes peroxidase
T3062 26596-26606 P28314 denotes peroxidase
T3063 26596-26606 P16147 denotes peroxidase
T3064 26596-26606 B3EWG7 denotes peroxidase
T3065 26608-26611 PR:Q0V967 denotes HRP
T3066 26608-26611 Q08168 denotes HRP
T3067 26643-26653 D000906 denotes antibodies
T3068 26688-26703 GO:0003824 denotes Enzyme activity
T3069 26761-26764 P55797 denotes ECL
T3070 26761-26764 PR:P55797 denotes ECL
T3071 26761-26764 P83410 denotes ECL
T3072 26761-26764 CL:0000504 denotes ECL
T3073 26948-26951 PR:P41134 denotes Id1
T3074 26948-26951 PR:P20067 denotes Id1
T3075 26948-26951 PR:P41135 denotes Id1
T3076 26948-26951 PR:000000039 denotes Id1
T3077 26953-26956 PR:000000040 denotes Id2
T3078 26953-26956 PR:P41137 denotes Id2
T3079 26953-26956 PR:Q02363 denotes Id2
T3080 26953-26956 PR:P41136 denotes Id2
T3081 26953-26956 C039556 denotes Id2
T3082 26953-26956 C039556 denotes Id2
T3083 26961-26964 PR:P41133 denotes Id3
T3084 26961-26964 PR:P41138 denotes Id3
T3085 26961-26964 PR:Q02535 denotes Id3
T3086 26961-26964 PR:000000041 denotes Id3
T3087 26965-26972 PR:000000001 denotes protein
T3088 26965-26972 CHEBI:36080 denotes protein
T3089 26965-26972 CHEBI:11122 denotes protein
T3090 26965-26972 GO:0003675 denotes protein
T3091 26965-26972 SO:0000104 denotes protein
T3092 27016-27023 PR:000000001 denotes protein
T3093 27016-27023 CHEBI:36080 denotes protein
T3094 27016-27023 CHEBI:11122 denotes protein
T3095 27016-27023 GO:0003675 denotes protein
T3096 27016-27023 SO:0000104 denotes protein
T3097 27033-27040 O42161 denotes β-actin
T3098 27033-27040 Q5R1X3 denotes β-actin
T3099 27033-27040 Q9Y702 denotes β-actin
T3100 27033-27040 P60706 denotes β-actin
T3101 27033-27040 P29751 denotes β-actin
T3102 27033-27040 P68143 denotes β-actin
T3103 27033-27040 P83750 denotes β-actin
T3104 27033-27040 P60710 denotes β-actin
T3105 27033-27040 Q71FK5 denotes β-actin
T3106 27033-27040 P60711 denotes β-actin
T3107 27033-27040 Q76N69 denotes β-actin
T3108 27033-27040 P79818 denotes β-actin
T3109 27033-27040 P60713 denotes β-actin
T3110 27033-27040 PR:000003676 denotes β-actin
T3111 27033-27040 Q0PGG4 denotes β-actin
T3112 27033-27040 Q6QAQ1 denotes β-actin
T3113 27033-27040 P84336 denotes β-actin
T3114 27033-27040 O93400 denotes β-actin
T3115 27033-27040 Q711N9 denotes β-actin
T3116 27033-27040 O18840 denotes β-actin
T3117 27033-27040 P48975 denotes β-actin
T3118 27033-27040 Q4L0Y2 denotes β-actin
T3119 27033-27040 Q5R6G0 denotes β-actin
T3120 27033-27040 P83751 denotes β-actin
T3121 27033-27040 P60707 denotes β-actin
T3122 27033-27040 P60709 denotes β-actin
T3123 27033-27040 P60712 denotes β-actin
T3124 27033-27040 Q91ZK5 denotes β-actin
T3125 27033-27040 P15475 denotes β-actin
T3126 27033-27040 Q6NVA9 denotes β-actin
T3127 27033-27040 P84856 denotes β-actin
T3128 27033-27040 Q4R561 denotes β-actin
T3129 27033-27040 P60708 denotes β-actin
T3130 27033-27040 D000199 denotes β-actin
T3131 27107-27112 D055418 denotes BMP-6
T3132 27107-27112 D055418 denotes BMP-6
T3133 27107-27112 Q04906 denotes BMP-6
T3134 27107-27112 PR:000000167 denotes BMP-6
T3135 27107-27112 P20722 denotes BMP-6
T3136 27107-27112 PR:Q04906 denotes BMP-6
T3137 27107-27112 P22004 denotes BMP-6
T3138 27107-27112 PR:P22004 denotes BMP-6
T3139 27107-27112 PR:P20722 denotes BMP-6
T3140 27113-27126 D012333 denotes messenger RNA
T3141 27113-27126 CHEBI:33699 denotes messenger RNA
T3142 27113-27126 SO:0000234 denotes messenger RNA
T3143 27123-27126 GO:0005562 denotes RNA
T3144 27128-27132 D012333 denotes mRNA
T3145 27128-27132 CHEBI:33699 denotes mRNA
T3146 27128-27132 SO:0000234 denotes mRNA
T3147 27174-27179 D055418 denotes BMP-6
T3148 27174-27179 D055418 denotes BMP-6
T3149 27174-27179 Q04906 denotes BMP-6
T3150 27174-27179 PR:000000167 denotes BMP-6
T3151 27174-27179 P20722 denotes BMP-6
T3152 27174-27179 PR:Q04906 denotes BMP-6
T3153 27174-27179 P22004 denotes BMP-6
T3154 27174-27179 PR:P22004 denotes BMP-6
T3155 27174-27179 PR:P20722 denotes BMP-6
T3156 27180-27184 SO:0000704 denotes gene
T3157 27201-27208 SO:0001031 denotes reverse
T3158 27201-27222 GO:0001171 denotes reverse transcription
T3159 27234-27239 SO:0000419 denotes chain
T3160 27234-27248 MOP:0000635 denotes chain reaction
T3161 27256-27259 CHEBI:33697 denotes RNA
T3162 27256-27259 D012313 denotes RNA
T3163 27256-27259 GO:0005562 denotes RNA
T3164 27256-27259 SO:0000356 denotes RNA
T3165 27290-27293 CHEBI:33697 denotes RNA
T3166 27290-27293 D012313 denotes RNA
T3167 27290-27293 GO:0005562 denotes RNA
T3168 27290-27293 SO:0000356 denotes RNA
T3169 27298-27301 Q41249 denotes PCR
T3170 27298-27301 O66148 denotes PCR
T3171 27298-27301 Q59987 denotes PCR
T3172 27298-27301 Q01289 denotes PCR
T3173 27298-27301 O80333 denotes PCR
T3174 27298-27301 P15904 denotes PCR
T3175 27298-27301 Q9SDT1 denotes PCR
T3176 27298-27301 Q39617 denotes PCR
T3177 27311-27314 PR:P05532 denotes Kit
T3178 27440-27443 CHEBI:33697 denotes RNA
T3179 27440-27443 D012313 denotes RNA
T3180 27440-27443 GO:0005562 denotes RNA
T3181 27440-27443 SO:0000356 denotes RNA
T3182 27522-27525 CHEBI:33697 denotes RNA
T3183 27522-27525 D012313 denotes RNA
T3184 27522-27525 GO:0005562 denotes RNA
T3185 27522-27525 SO:0000356 denotes RNA
T3186 27536-27543 SO:0001031 denotes reverse
T3187 27559-27563 D018076 denotes cDNA
T3188 27559-27563 SO:0000756 denotes cDNA
T3189 27577-27584 SO:0001031 denotes Reverse
T3190 27577-27598 GO:0001171 denotes Reverse Transcription
T3191 27599-27607 CHEBI:33893 denotes Reagents
T3192 27599-27607 D007202 denotes Reagents
T3193 27665-27669 D012333 denotes mRNA
T3194 27665-27669 CHEBI:33699 denotes mRNA
T3195 27665-27669 SO:0000234 denotes mRNA
T3196 27684-27688 D055418 denotes BMP6
T3197 27684-27688 D055418 denotes BMP6
T3198 27684-27688 Q04906 denotes BMP6
T3199 27684-27688 PR:000000167 denotes BMP6
T3200 27684-27688 P20722 denotes BMP6
T3201 27684-27688 PR:Q04906 denotes BMP6
T3202 27684-27688 P22004 denotes BMP6
T3203 27684-27688 PR:P22004 denotes BMP6
T3204 27684-27688 PR:P20722 denotes BMP6
T3205 27690-27693 PR:P41134 denotes Id1
T3206 27690-27693 PR:P20067 denotes Id1
T3207 27690-27693 PR:P41135 denotes Id1
T3208 27690-27693 PR:000000039 denotes Id1
T3209 27694-27697 PR:P47928 denotes Id4
T3210 27694-27697 PR:P41139 denotes Id4
T3211 27694-27697 PR:000000042 denotes Id4
T3212 27702-27705 GO:0004618 denotes PGK
T3213 27702-27706 PR:P00558 denotes PGK1
T3214 27702-27706 PR:P91427 denotes PGK1
T3215 27702-27706 PR:P09411 denotes PGK1
T3216 27702-27706 PR:P00560 denotes PGK1
T3217 27702-27706 PR:O60101 denotes PGK1
T3218 27702-27706 PR:P46273 denotes PGK1
T3219 27702-27706 PR:000012607 denotes PGK1
T3220 27702-27706 PR:Q9LD57 denotes PGK1
T3221 27702-27706 PR:P16617 denotes PGK1
T3222 27707-27710 Q41249 denotes PCR
T3223 27707-27710 O66148 denotes PCR
T3224 27707-27710 Q59987 denotes PCR
T3225 27707-27710 Q01289 denotes PCR
T3226 27707-27710 O80333 denotes PCR
T3227 27707-27710 P15904 denotes PCR
T3228 27707-27710 Q9SDT1 denotes PCR
T3229 27707-27710 Q39617 denotes PCR
T3230 27837-27840 Q41249 denotes PCR
T3231 27837-27840 O66148 denotes PCR
T3232 27837-27840 Q59987 denotes PCR
T3233 27837-27840 Q01289 denotes PCR
T3234 27837-27840 O80333 denotes PCR
T3235 27837-27840 P15904 denotes PCR
T3236 27837-27840 Q9SDT1 denotes PCR
T3237 27837-27840 Q39617 denotes PCR
T3238 27896-27901 Q04906 denotes BMP-6
T3239 27896-27901 PR:000000167 denotes BMP-6
T3240 27896-27901 P20722 denotes BMP-6
T3241 27896-27901 PR:Q04906 denotes BMP-6
T3242 27896-27901 P22004 denotes BMP-6
T3243 27896-27901 PR:P22004 denotes BMP-6
T3244 27896-27901 PR:P20722 denotes BMP-6
T3245 27896-27901 D055418 denotes BMP-6
T3246 27896-27901 D055418 denotes BMP-6
T3247 27913-27916 PR:P41134 denotes ID1
T3248 27913-27916 PR:P20067 denotes ID1
T3249 27913-27916 PR:P41135 denotes ID1
T3250 27913-27916 PR:000000039 denotes ID1
T3251 27923-27927 SO:0000756 denotes cDNA
T3252 27923-27927 D018076 denotes cDNA
T3253 27997-28000 SO:0000356 denotes RNA
T3254 27997-28000 CHEBI:33697 denotes RNA
T3255 27997-28000 D012313 denotes RNA
T3256 27997-28000 GO:0005562 denotes RNA
T3257 28006-28010 SO:0000704 denotes gene
T3258 28006-28021 GO:0010467 denotes gene expression
T3259 28070-28074 D055418 denotes BMP6
T3260 28070-28074 D055418 denotes BMP6
T3261 28070-28074 Q04906 denotes BMP6
T3262 28070-28074 PR:000000167 denotes BMP6
T3263 28070-28074 P20722 denotes BMP6
T3264 28070-28074 PR:Q04906 denotes BMP6
T3265 28070-28074 P22004 denotes BMP6
T3266 28070-28074 PR:P22004 denotes BMP6
T3267 28070-28074 PR:P20722 denotes BMP6
T3268 28107-28110 PR:P41134 denotes Id1
T3269 28107-28110 PR:P20067 denotes Id1
T3270 28107-28110 PR:P41135 denotes Id1
T3271 28107-28110 PR:000000039 denotes Id1
T3272 28236-28239 GO:0004618 denotes PGK
T3273 28236-28240 PR:P00558 denotes PGK1
T3274 28236-28240 PR:P91427 denotes PGK1
T3275 28236-28240 PR:P09411 denotes PGK1
T3276 28236-28240 PR:P00560 denotes PGK1
T3277 28236-28240 PR:O60101 denotes PGK1
T3278 28236-28240 PR:P46273 denotes PGK1
T3279 28236-28240 PR:000012607 denotes PGK1
T3280 28236-28240 PR:Q9LD57 denotes PGK1
T3281 28236-28240 PR:P16617 denotes PGK1
T3282 28242-28245 GO:0004618 denotes PGK
T3283 28242-28246 PR:P00558 denotes PGK1
T3284 28242-28246 PR:P91427 denotes PGK1
T3285 28242-28246 PR:P09411 denotes PGK1
T3286 28242-28246 PR:P00560 denotes PGK1
T3287 28242-28246 PR:O60101 denotes PGK1
T3288 28242-28246 PR:P46273 denotes PGK1
T3289 28242-28246 PR:000012607 denotes PGK1
T3290 28242-28246 PR:Q9LD57 denotes PGK1
T3291 28242-28246 PR:P16617 denotes PGK1
T3292 28326-28336 CL:0000542 denotes lymphocyte
T3293 28428-28433 CVCL_0597 denotes Ramos
T3294 28442-28460 GO:0008283 denotes Cell proliferation
T3295 28447-28460 UBERON:2000098 denotes proliferation
T3296 28479-28482 GO:0005574 denotes DNA
T3297 28479-28482 CHEBI:16991 denotes DNA
T3298 28479-28482 D004247 denotes DNA
T3299 28479-28482 SO:0000352 denotes DNA
T3300 28479-28492 GO:0071897 denotes DNA synthesis
T3301 28494-28498 PR:P25918 denotes CD19
T3302 28494-28498 PR:P15391 denotes CD19
T3303 28494-28498 PR:000001002 denotes CD19
T3304 28534-28539 CVCL_0597 denotes Ramos
T3305 28658-28670 CHEBI:53526 denotes 3H]thymidine
T3306 28854-28866 CHEBI:53526 denotes 3H]thymidine
T3307 28961-28964 UBERON:0035973 denotes Inc
T3308 28999-29009 GO:0008219 denotes cell death
T3309 29010-29020 GO:0008219 denotes Cell death
T3310 29043-29046 PR:Q7ZU29 denotes dye
T3311 29043-29046 PR:P0A9Q1 denotes dye
T3312 29043-29046 PR:000022123 denotes dye
T3313 29043-29046 CHEBI:37958 denotes dye
T3314 29093-29109 D011419 denotes propidium iodide
T3315 29093-29109 D011419 denotes propidium iodide
T3316 29093-29109 CHEBI:51240 denotes propidium iodide
T3317 29145-29150 PR:000004921 denotes CA; 5
T3318 29145-29150 PR:P43165 denotes CA; 5
T3319 29145-29150 PR:P23589 denotes CA; 5
T3320 29145-29150 PR:P35218 denotes CA; 5
T3321 29447-29450 UBERON:0035973 denotes Inc
T3322 29548-29551 CHEBI:60815 denotes BMP
T3323 29548-29551 PR:000000034 denotes BMP
T3324 29548-29551 P35855 denotes BMP
T3325 29553-29579 D019485 denotes Bone morphogenetic protein
T3326 29553-29579 D019485 denotes Bone morphogenetic protein
T3327 29558-29579 P07580 denotes morphogenetic protein
T3328 29572-29579 GO:0003675 denotes protein
T3329 29572-29579 SO:0000104 denotes protein
T3330 29587-29616 D016403 denotes diffuse large B cell lymphoma
T3331 29587-29616 D016403 denotes diffuse large B cell lymphoma
T3332 29601-29607 CL:0000236 denotes B cell
T3333 29621-29630 CHEBI:35222 denotes inhibitor
T3334 29634-29645 GO:0003677 denotes dna binding
T3335 29638-29645 SO:0100018 denotes binding
T3336 29638-29645 SO:0001091 denotes binding
T3337 29686-29696 2294143 denotes Drosophila
T3338 29686-29696 504603 denotes Drosophila
T3339 29686-29696 2294139 denotes Drosophila
T3340 29686-29696 2294145 denotes Drosophila
T3341 29686-29696 2294141 denotes Drosophila
T3342 29686-29696 2294142 denotes Drosophila
T3343 29686-29696 2294144 denotes Drosophila
T3344 29686-29696 2294140 denotes Drosophila
T3345 29686-29696 D004330 denotes Drosophila
T3346 29686-29696 2080301 denotes Drosophila
T3347 29697-29704 CHEBI:36080 denotes protein
T3348 29697-29704 CHEBI:11122 denotes protein
T3349 29697-29704 GO:0003675 denotes protein
T3350 29697-29704 SO:0000104 denotes protein
T3351 29697-29709 Q05195 denotes protein, MAD
T3352 29697-29709 PR:000010790 denotes protein, MAD
T3353 29697-29709 Q0VH34 denotes protein, MAD
T3354 29697-29709 P50538 denotes protein, MAD
T3355 29697-29709 Q0VFI9 denotes protein, MAD
T3356 29706-29709 C110804 denotes MAD
T3357 29706-29709 CHEBI:73609 denotes MAD
T3358 29706-29709 C110804 denotes MAD
T3359 29706-29709 GO:0072671 denotes MAD
T3360 29718-29740 D017173 denotes Caenorhabditis elegans
T3361 29718-29740 6239 denotes Caenorhabditis elegans
T3362 29718-29749 D029742 denotes Caenorhabditis elegans proteins
T3363 29751-29756 PR:Q9US26 denotes sma-2
T3364 29751-29756 PR:Q04658 denotes sma-2
T3365 29751-29756 PR:Q02330 denotes sma-2
T3366 29751-29756 D014897 denotes sma-2
T3367 29751-29756 CVCL_WB08 denotes sma-2
T3368 29751-29756 CVCL_UB67 denotes sma-2
T3369 29766-29770 P08457 denotes STAT
T3370 29766-29770 PR:P35610 denotes STAT
T3371 29766-29770 PR:000015389 denotes STAT
T3372 29766-29770 PR:Q24151 denotes STAT
T3373 29772-29778 SO:0000725 denotes signal
T3374 29772-29778 SO:0000418 denotes signal
T3375 29807-29820 GO:0006351 denotes transcription
T3376 29919-29922 PR:P54352 denotes EAS
T3377 29919-29922 Q40577 denotes EAS
T3378 29977-29980 P07099 denotes MEH
T3379 29977-29980 Q9D379 denotes MEH
T3380 29977-29980 PR:Q9D379 denotes MEH
T3381 29977-29980 P79381 denotes MEH
T3382 29977-29980 P04068 denotes MEH
T3383 29977-29980 P07687 denotes MEH
T3384 29977-29980 GO:0033961 denotes MEH
T3385 30074-30077 PR:F4JL28 denotes EBS
T3386 30074-30077 PR:Q9BTE0 denotes EBS
T3387 30074-30077 PR:000011005 denotes EBS