PMC:1088007 / 9399-12394 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1088007","sourcedb":"PMC","sourceid":"1088007","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1088007","text":"Results\n\nPatients' characteristics\nOur sample consisted of thirty eight women. Ninenteen were included in the Group 1 and ninenteen in the Group 2.\nAge and duration of illness were comparable between the two groups (Table 1).\nTable 1 Diagnosis, duration of illness, psychoactive treatment before recruitment and age of patients Schizoaf: Schizoaffective Disorder; Schiz: Schizophrenia; Bip Dis: Bipolar Disorder; An Nervosa: norexia Nervosa; Alc Abuse: Alcohol Abuse yr: years Data on diagnosis and previous pharmacological treatment of patients are reported in Table 1.\nAmong the nineteen patients in Group 1, five were treated with haloperidol, five with olanzapine, five with risperidone and four with clozapine; among the nineteen patients of group 2, five started haloperidol, eight olanzapine, four risperidone and two quetiapine. Antidepressant used were escitalopram (two patients), citalopram (three patients), mirtazapine (four patients), paroxetine (one patients), sertraline (two), fluvoxamine (one patient), venlafaxine (three patients), clomipramine (two patients). Three patients started also lithium treatment.\nThe mean antipsychotic doses, equivalent doses and mean plasmatic levels are reported in Table 2 (See Additional file 1 ). Potassium and magnesium serum levels were always within the normal range for all subjects.\n\nQTc interval\nMean baseline QTc intervals were similar in the two groups: 422 ± 26 ms in group 1 and 414 ± 22 ms in group 2 (Indipendent T-test p \u003e 0,5). One patient in the monotherapy group, who started clozapine treatment, was excluded from this analysis and from pre-post treatment comparisons because QTc in DII was not measurable with sufficient accuracy.\nThree patients in the first group had QTc values that exceeded 450 ms at baseline while no patients in Group 2 exceeded this threshold before starting treatment.\nThe average QTc interval after treatment was 421 ± 20 ms in the monotherapy group (range 391–452) and 438 ± 30 and in the polytherapy group (range 379–488) (Indipendent T test, p \u003c 0,05) (see figure 1).\nFigure 1 Mean QTc (bars indicate standard deviations) values at baseline (T0) and after four days at full dosage (T1) of antipsychotic therapy, in the monotherapy (1) and politherapy (2) groups. Compared with the baseline, mean QTc change after treatment was – 1 ± 30 ms in Group 1 and 24 ± 21 ms in Group 2 (repeated measures ANOVA p \u003c 0,05).\nAfter treatment only one patient in Group 1 reached the threshold for borderline values of QTc interval in comparison to seven patients in Group 2 (Fisher Exact Text p \u003c 0,05).\nMoreover, in Group 2 two patients had a QTc exceeding 480 ms.\nThe highest prolongations of QTc intervals (66 ms and 55 ms) were found in two patients taking risperidone, the first in association to clomipramine and the second in association to escitalopram. However in these two cases plasmatic dosages of antipsychotics were not higher than in other patients who reported a shorter QTc prolongation.\n","divisions":[{"label":"Title","span":{"begin":0,"end":7}},{"label":"Section","span":{"begin":9,"end":1343}},{"label":"Title","span":{"begin":9,"end":34}},{"label":"Table caption","span":{"begin":226,"end":479}},{"label":"Section","span":{"begin":1345,"end":2994}},{"label":"Title","span":{"begin":1345,"end":1357}},{"label":"Figure 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