PMC:1087494 / 23383-24900 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1087494","sourcedb":"PMC","sourceid":"1087494","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1087494","text":"Conclusion\nTopiramate appears a very useful drug for weight reduction in patients with bipolar disorders. The mood stabilizing effect of topiramate is however questionable. The very different results obtained from the controlled monotherapy trials of topiramate in mania and the open add-on trials summarised in the Background indicate that topiramate should not be prescribed as monotherapy in bipolar disorders as it has no acute antimanic effect. In our opinion the current place of topiramate in the treatment of affective disorders is as an add-on treatment for patients who experience clinically significant weight gain, which could either compromise their physical health, or influence them to stop taking established mood stabilizers.\n\nRecommendations\nTopiramate should not be used in monotherapy and unless new research shows otherwise, psychiatrists should assume that it has no mood-stabilizing properties.\n\nDose titration\nTopiramate dose should be increased gradually and in two-weekly intervals.\n\nCognitive function\nTopiramate is known to cause neurocognitive side effects. Psychiatrists should monitor their patients carefully for the emergence of such side effects.\n\nPregnancy\nAs with most other mood-stabilizers (anticonvulsants and lithium), women who may become pregnant should be warned of the possible consequences of taking such drugs during pregnancy [37].\n\nAdequate hydration\nPatients should be advised to ensure adequate hydration, especially if they are predisposed to nephrolithiasis [37].\n\n","divisions":[{"label":"Title","span":{"begin":0,"end":10}},{"label":"Section","span":{"begin":744,"end":1516}},{"label":"Title","span":{"begin":744,"end":759}},{"label":"Section","span":{"begin":919,"end":1008}},{"label":"Title","span":{"begin":919,"end":933}},{"label":"Section","span":{"begin":1010,"end":1180}},{"label":"Title","span":{"begin":1010,"end":1028}},{"label":"Section","span":{"begin":1182,"end":1378}},{"label":"Title","span":{"begin":1182,"end":1191}},{"label":"Section","span":{"begin":1380,"end":1515}},{"label":"Title","span":{"begin":1380,"end":1398}}],"tracks":[{"project":"biosemtest","denotations":[{"id":"T2396","span":{"begin":701,"end":705},"obj":"UMLS/C0450446"},{"id":"T2397","span":{"begin":218,"end":228},"obj":"UMLS/C0243148"},{"id":"T2398","span":{"begin":44,"end":48},"obj":"UMLS/C1254351"},{"id":"T2399","span":{"begin":218,"end":228},"obj":"UMLS/C1882979"},{"id":"T2400","span":{"begin":713,"end":724},"obj":"UMLS/C1272684"},{"id":"T2401","span":{"begin":182,"end":191},"obj":"UMLS/C1705242"},{"id":"T2402","span":{"begin":218,"end":228},"obj":"UMLS/C1550141"},{"id":"T2403","span":{"begin":279,"end":283},"obj":"UMLS/C1882151"},{"id":"T2404","span":{"begin":110,"end":114},"obj":"UMLS/C2713234"},{"id":"T2405","span":{"begin":725,"end":729},"obj":"UMLS/C2713234"},{"id":"T2406","span":{"begin":706,"end":712},"obj":"UMLS/C1883727"},{"id":"T2407","span":{"begin":701,"end":705},"obj":"UMLS/C1522314"},{"id":"T2408","span":{"begin":602,"end":613},"obj":"UMLS/C0750502"},{"id":"T2409","span":{"begin":73,"end":81},"obj":"UMLS/C0030705"},{"id":"T2410","span":{"begin":567,"end":575},"obj":"UMLS/C0030705"},{"id":"T2411","span":{"begin":115,"end":126},"obj":"UMLS/C0184512"},{"id":"T2412","span":{"begin":426,"end":431},"obj":"UMLS/C1547295"},{"id":"T2413","span":{"begin":477,"end":482},"obj":"UMLS/C1882509"},{"id":"T2414","span":{"begin":469,"end":476},"obj":"UMLS/C0521116"},{"id":"T2415","span":{"begin":284,"end":290},"obj":"UMLS/C1883712"},{"id":"T2416","span":{"begin":546,"end":552},"obj":"UMLS/C1883712"},{"id":"T2417","span":{"begin":218,"end":228},"obj":"UMLS/C0009932"},{"id":"T2418","span":{"begin":419,"end":422},"obj":"UMLS/C2348947"},{"id":"T2419","span":{"begin":366,"end":376},"obj":"UMLS/C0278329"},{"id":"T2420","span":{"begin":698,"end":700},"obj":"UMLS/C0319022"},{"id":"T2421","span":{"begin":504,"end":513},"obj":"UMLS/C0039798"},{"id":"T2422","span":{"begin":553,"end":562},"obj":"UMLS/C0039798"},{"id":"T2423","span":{"begin":279,"end":283},"obj":"UMLS/C0175566"},{"id":"T2424","span":{"begin":730,"end":741},"obj":"UMLS/C1705532"},{"id":"T2425","span":{"begin":192,"end":199},"obj":"UMLS/C1274040"},{"id":"T2426","span":{"begin":192,"end":199},"obj":"UMLS/C0332294"},{"id":"T2427","span":{"begin":110,"end":114},"obj":"UMLS/C0026516"},{"id":"T2428","span":{"begin":725,"end":729},"obj":"UMLS/C0026516"},{"id":"T2429","span":{"begin":517,"end":536},"obj":"UMLS/C0525045"},{"id":"T2430","span":{"begin":316,"end":326},"obj":"UMLS/C1706907"},{"id":"T2431","span":{"begin":127,"end":133},"obj":"UMLS/C1280500"},{"id":"T2432","span":{"begin":442,"end":448},"obj":"UMLS/C1280500"},{"id":"T2433","span":{"begin":200,"end":208},"obj":"UMLS/C1301820"},{"id":"T2434","span":{"begin":73,"end":81},"obj":"UMLS/C1705908"},{"id":"T2435","span":{"begin":567,"end":575},"obj":"UMLS/C1705908"},{"id":"T2436","span":{"begin":284,"end":290},"obj":"UMLS/C1524062"},{"id":"T2437","span":{"begin":546,"end":552},"obj":"UMLS/C1524062"},{"id":"T2438","span":{"begin":218,"end":228},"obj":"UMLS/C0332298"},{"id":"T2439","span":{"begin":432,"end":441},"obj":"UMLS/C0242911"},{"id":"T2440","span":{"begin":11,"end":21},"obj":"UMLS/C0076829"},{"id":"T2441","span":{"begin":137,"end":147},"obj":"UMLS/C0076829"},{"id":"T2442","span":{"begin":251,"end":261},"obj":"UMLS/C0076829"},{"id":"T2443","span":{"begin":341,"end":351},"obj":"UMLS/C0076829"},{"id":"T2444","span":{"begin":486,"end":496},"obj":"UMLS/C0076829"},{"id":"T2445","span":{"begin":241,"end":247},"obj":"UMLS/C0008976"},{"id":"T2446","span":{"begin":291,"end":297},"obj":"UMLS/C0008976"},{"id":"T2447","span":{"begin":218,"end":228},"obj":"UMLS/C1547100"},{"id":"T2448","span":{"begin":706,"end":712},"obj":"UMLS/C1515187"},{"id":"T2449","span":{"begin":192,"end":199},"obj":"UMLS/C1280519"},{"id":"T2450","span":{"begin":359,"end":362},"obj":"UMLS/C1518422"},{"id":"T2451","span":{"begin":426,"end":431},"obj":"UMLS/C0205178"},{"id":"T2452","span":{"begin":284,"end":290},"obj":"UMLS/C1720086"},{"id":"T2453","span":{"begin":546,"end":552},"obj":"UMLS/C1720086"},{"id":"T2454","span":{"begin":701,"end":705},"obj":"UMLS/C1947925"},{"id":"T2455","span":{"begin":663,"end":678},"obj":"UMLS/C0516977"},{"id":"T2456","span":{"begin":477,"end":482},"obj":"UMLS/C1704765"},{"id":"T2457","span":{"begin":73,"end":81},"obj":"UMLS/C1550655"},{"id":"T2458","span":{"begin":567,"end":575},"obj":"UMLS/C1550655"},{"id":"T2459","span":{"begin":192,"end":199},"obj":"UMLS/C1546471"},{"id":"T2460","span":{"begin":87,"end":104},"obj":"UMLS/C0005586"},{"id":"T2461","span":{"begin":395,"end":412},"obj":"UMLS/C0005586"},{"id":"T2462","span":{"begin":426,"end":431},"obj":"UMLS/C1547229"},{"id":"T2463","span":{"begin":127,"end":133},"obj":"UMLS/C2348382"},{"id":"T2464","span":{"begin":442,"end":448},"obj":"UMLS/C2348382"},{"id":"T2465","span":{"begin":200,"end":208},"obj":"UMLS/C1706701"},{"id":"T2466","span":{"begin":504,"end":513},"obj":"UMLS/C1705169"},{"id":"T2467","span":{"begin":553,"end":562},"obj":"UMLS/C1705169"},{"id":"T2468","span":{"begin":298,"end":308},"obj":"UMLS/C1553398"},{"id":"T2469","span":{"begin":633,"end":638},"obj":"UMLS/C0006823"},{"id":"T2470","span":{"begin":44,"end":48},"obj":"UMLS/C0013227"},{"id":"T2471","span":{"begin":504,"end":513},"obj":"UMLS/C1522326"},{"id":"T2472","span":{"begin":553,"end":562},"obj":"UMLS/C1522326"},{"id":"T2473","span":{"begin":730,"end":741},"obj":"UMLS/C1550603"},{"id":"T2474","span":{"begin":265,"end":270},"obj":"UMLS/C0338831"},{"id":"T2475","span":{"begin":327,"end":335},"obj":"UMLS/C1444656"},{"id":"T2476","span":{"begin":602,"end":613},"obj":"UMLS/C1546944"},{"id":"T2477","span":{"begin":504,"end":513},"obj":"UMLS/C0087111"},{"id":"T2478","span":{"begin":553,"end":562},"obj":"UMLS/C0087111"},{"id":"T2479","span":{"begin":713,"end":724},"obj":"UMLS/C0443211"},{"id":"T2480","span":{"begin":730,"end":741},"obj":"UMLS/C0920880"},{"id":"T2481","span":{"begin":614,"end":625},"obj":"UMLS/C0043094"},{"id":"T2482","span":{"begin":73,"end":81},"obj":"UMLS/C1578485"},{"id":"T2483","span":{"begin":567,"end":575},"obj":"UMLS/C1578485"},{"id":"T2484","span":{"begin":218,"end":228},"obj":"UMLS/C2587213"},{"id":"T2485","span":{"begin":73,"end":81},"obj":"UMLS/C1578484"},{"id":"T2486","span":{"begin":567,"end":575},"obj":"UMLS/C1578484"},{"id":"T2487","span":{"begin":53,"end":69},"obj":"UMLS/C0043096"},{"id":"T2488","span":{"begin":633,"end":638},"obj":"UMLS/C0344312"},{"id":"T2489","span":{"begin":504,"end":513},"obj":"UMLS/C1533734"},{"id":"T2490","span":{"begin":553,"end":562},"obj":"UMLS/C1533734"},{"id":"T2491","span":{"begin":73,"end":81},"obj":"UMLS/C1578486"},{"id":"T2492","span":{"begin":567,"end":575},"obj":"UMLS/C1578486"},{"id":"T2493","span":{"begin":73,"end":81},"obj":"UMLS/C1578481"},{"id":"T2494","span":{"begin":567,"end":575},"obj":"UMLS/C1578481"},{"id":"T2495","span":{"begin":73,"end":81},"obj":"UMLS/C1578480"},{"id":"T2496","span":{"begin":567,"end":575},"obj":"UMLS/C1578480"},{"id":"T2497","span":{"begin":73,"end":81},"obj":"UMLS/C1578483"},{"id":"T2498","span":{"begin":567,"end":575},"obj":"UMLS/C1578483"},{"id":"T2499","span":{"begin":469,"end":476},"obj":"UMLS/C1705970"},{"id":"T2500","span":{"begin":73,"end":81},"obj":"UMLS/C1578479"},{"id":"T2501","span":{"begin":567,"end":575},"obj":"UMLS/C1578479"},{"id":"T2524","span":{"begin":998,"end":1007},"obj":"UMLS/C1552713"},{"id":"T2525","span":{"begin":960,"end":969},"obj":"UMLS/C0205217"},{"id":"T2526","span":{"begin":919,"end":923},"obj":"UMLS/C1114758"},{"id":"T2527","span":{"begin":919,"end":923},"obj":"UMLS/C0178602"},{"id":"T2528","span":{"begin":960,"end":969},"obj":"UMLS/C0442808"},{"id":"T2529","span":{"begin":924,"end":933},"obj":"UMLS/C0162621"},{"id":"T2530","span":{"begin":919,"end":923},"obj":"UMLS/C0869039"},{"id":"T2531","span":{"begin":934,"end":949},"obj":"UMLS/C1148279"},{"id":"T2532","span":{"begin":998,"end":1007},"obj":"UMLS/C1272706"},{"id":"T2533","span":{"begin":960,"end":969},"obj":"UMLS/C0442805"},{"id":"T2534","span":{"begin":998,"end":1007},"obj":"UMLS/C1552654"},{"id":"T2535","span":{"begin":1029,"end":1039},"obj":"UMLS/C0076829"},{"id":"T2536","span":{"begin":1108,"end":1115},"obj":"UMLS/C1521743"},{"id":"T2537","span":{"begin":1108,"end":1115},"obj":"UMLS/C0596972"},{"id":"T2538","span":{"begin":1122,"end":1130},"obj":"UMLS/C0030705"},{"id":"T2539","span":{"begin":1108,"end":1115},"obj":"UMLS/C0728873"},{"id":"T2540","span":{"begin":1122,"end":1130},"obj":"UMLS/C1550655"},{"id":"T2541","span":{"begin":1073,"end":1085},"obj":"UMLS/C0001688"},{"id":"T2542","span":{"begin":1167,"end":1179},"obj":"UMLS/C0001688"},{"id":"T2543","span":{"begin":1052,"end":1057},"obj":"UMLS/C0015127"},{"id":"T2544","span":{"begin":1052,"end":1057},"obj":"UMLS/C0678227"},{"id":"T2545","span":{"begin":1108,"end":1115},"obj":"UMLS/C1516647"},{"id":"T2546","span":{"begin":1052,"end":1057},"obj":"UMLS/C1314792"},{"id":"T2547","span":{"begin":1043,"end":1048},"obj":"UMLS/C0205309"},{"id":"T2548","span":{"begin":1049,"end":1051},"obj":"UMLS/C0319022"},{"id":"T2549","span":{"begin":1073,"end":1085},"obj":"UMLS/C0879626"},{"id":"T2550","span":{"begin":1167,"end":1179},"obj":"UMLS/C0879626"},{"id":"T2551","span":{"begin":1108,"end":1115},"obj":"UMLS/C0150369"},{"id":"T2552","span":{"begin":1108,"end":1115},"obj":"UMLS/C1704646"},{"id":"T2553","span":{"begin":1122,"end":1130},"obj":"UMLS/C1578485"},{"id":"T2554","span":{"begin":1122,"end":1130},"obj":"UMLS/C1578484"},{"id":"T2555","span":{"begin":1122,"end":1130},"obj":"UMLS/C1578486"},{"id":"T2556","span":{"begin":1087,"end":1100},"obj":"UMLS/C0033872"},{"id":"T2557","span":{"begin":1122,"end":1130},"obj":"UMLS/C1578481"},{"id":"T2558","span":{"begin":1052,"end":1057},"obj":"UMLS/C1524003"},{"id":"T2559","span":{"begin":1108,"end":1115},"obj":"UMLS/C0181904"},{"id":"T2560","span":{"begin":1122,"end":1130},"obj":"UMLS/C1578480"},{"id":"T2561","span":{"begin":1122,"end":1130},"obj":"UMLS/C1578483"},{"id":"T2562","span":{"begin":1010,"end":1028},"obj":"UMLS/C0392335"},{"id":"T2563","span":{"begin":1122,"end":1130},"obj":"UMLS/C1705908"},{"id":"T2564","span":{"begin":1010,"end":1028},"obj":"UMLS/C0392334"},{"id":"T2565","span":{"begin":1122,"end":1130},"obj":"UMLS/C1578479"},{"id":"T2570","span":{"begin":1350,"end":1355},"obj":"UMLS/C0013227"},{"id":"T2571","span":{"begin":1313,"end":1321},"obj":"UMLS/C0332149"},{"id":"T2572","span":{"begin":1350,"end":1355},"obj":"UMLS/C1254351"},{"id":"T2573","span":{"begin":1299,"end":1305},"obj":"UMLS/C1578604"},{"id":"T2574","span":{"begin":1182,"end":1191},"obj":"UMLS/C0032961"},{"id":"T2575","span":{"begin":1363,"end":1372},"obj":"UMLS/C0032961"},{"id":"T2576","span":{"begin":1299,"end":1305},"obj":"UMLS/C1550014"},{"id":"T2577","span":{"begin":1299,"end":1305},"obj":"UMLS/C1578603"},{"id":"T2578","span":{"begin":1249,"end":1256},"obj":"UMLS/C0023870"},{"id":"T2579","span":{"begin":1338,"end":1344},"obj":"UMLS/C1515187"},{"id":"T2580","span":{"begin":1338,"end":1344},"obj":"UMLS/C1883727"},{"id":"T2581","span":{"begin":1299,"end":1305},"obj":"UMLS/C1578605"},{"id":"T2582","span":{"begin":1229,"end":1244},"obj":"UMLS/C0003286"},{"id":"T2583","span":{"begin":1313,"end":1321},"obj":"UMLS/C2362652"},{"id":"T2584","span":{"begin":1299,"end":1305},"obj":"UMLS/C1549021"},{"id":"T2585","span":{"begin":1299,"end":1305},"obj":"UMLS/C0871599"},{"id":"T2586","span":{"begin":1280,"end":1288},"obj":"UMLS/C0549206"},{"id":"T2587","span":{"begin":1205,"end":1210},"obj":"UMLS/C1556044"},{"id":"T2588","span":{"begin":1322,"end":1334},"obj":"UMLS/C0686907"},{"id":"T2589","span":{"begin":1313,"end":1321},"obj":"UMLS/C1705910"},{"id":"T2590","span":{"begin":1205,"end":1210},"obj":"UMLS/C1955473"},{"id":"T2591","span":{"begin":1269,"end":1272},"obj":"UMLS/C0337876"},{"id":"T2592","span":{"begin":1269,"end":1272},"obj":"UMLS/C0454788"},{"id":"T2603","span":{"begin":1380,"end":1398},"obj":"UMLS/C1998725"},{"id":"T2604","span":{"begin":1436,"end":1454},"obj":"UMLS/C1998725"},{"id":"T2605","span":{"begin":1429,"end":1435},"obj":"UMLS/C0218063"},{"id":"T2606","span":{"begin":1494,"end":1509},"obj":"UMLS/C0392525"},{"id":"T2607","span":{"begin":1426,"end":1428},"obj":"UMLS/C0319022"},{"id":"T2608","span":{"begin":1491,"end":1493},"obj":"UMLS/C0319022"},{"id":"T2609","span":{"begin":1399,"end":1407},"obj":"UMLS/C0030705"},{"id":"T2610","span":{"begin":1418,"end":1425},"obj":"UMLS/C1828381"},{"id":"T2611","span":{"begin":1399,"end":1407},"obj":"UMLS/C1550655"},{"id":"T2612","span":{"begin":1399,"end":1407},"obj":"UMLS/C1578485"},{"id":"T2613","span":{"begin":1399,"end":1407},"obj":"UMLS/C1578484"},{"id":"T2614","span":{"begin":1399,"end":1407},"obj":"UMLS/C1578486"},{"id":"T2615","span":{"begin":1399,"end":1407},"obj":"UMLS/C1578481"},{"id":"T2616","span":{"begin":1399,"end":1407},"obj":"UMLS/C1578480"},{"id":"T2617","span":{"begin":1399,"end":1407},"obj":"UMLS/C1578483"},{"id":"T2618","span":{"begin":1399,"end":1407},"obj":"UMLS/C1705908"},{"id":"T2619","span":{"begin":1399,"end":1407},"obj":"UMLS/C1578479"}],"attributes":[{"subj":"T2396","pred":"source","obj":"biosemtest"},{"subj":"T2397","pred":"source","obj":"biosemtest"},{"subj":"T2398","pred":"source","obj":"biosemtest"},{"subj":"T2399","pred":"source","obj":"biosemtest"},{"subj":"T2400","pred":"source","obj":"biosemtest"},{"subj":"T2401","pred":"source","obj":"biosemtest"},{"subj":"T2402","pred":"source","obj":"biosemtest"},{"subj":"T2403","pred":"source","obj":"biosemtest"},{"subj":"T2404","pred":"source","obj":"biosemtest"},{"subj":"T2405","pred":"source","obj":"biosemtest"},{"subj":"T2406","pred":"source","obj":"biosemtest"},{"subj":"T2407","pred":"source","obj":"biosemtest"},{"subj":"T2408","pred":"source","obj":"biosemtest"},{"subj":"T2409","pred":"source","obj":"biosemtest"},{"subj":"T2410","pred":"source","obj":"biosemtest"},{"subj":"T2411","pred":"source","obj":"biosemtest"},{"subj":"T2412","pred":"source","obj":"biosemtest"},{"subj":"T2413","pred":"source","obj":"biosemtest"},{"subj":"T2414","pred":"source","obj":"biosemtest"},{"subj":"T2415","pred":"source","obj":"biosemtest"},{"subj":"T2416","pred":"source","obj":"biosemtest"},{"subj":"T2417","pred":"source","obj":"biosemtest"},{"subj":"T2418","pred":"source","obj":"biosemtest"},{"subj":"T2419","pred":"source","obj":"biosemtest"},{"subj":"T2420","pred":"source","obj":"biosemtest"},{"subj":"T2421","pred":"source","obj":"biosemtest"},{"subj":"T2422","pred":"source","obj":"biosemtest"},{"subj":"T2423","pred":"source","obj":"biosemtest"},{"subj":"T2424","pred":"source","obj":"biosemtest"},{"subj":"T2425","pred":"source","obj":"biosemtest"},{"subj":"T2426","pred":"source","obj":"biosemtest"},{"subj":"T2427","pred":"source","obj":"biosemtest"},{"subj":"T2428","pred":"source","obj":"biosemtest"},{"subj":"T2429","pred":"source","obj":"biosemtest"},{"subj":"T2430","pred":"source","obj":"biosemtest"},{"subj":"T2431","pred":"source","obj":"biosemtest"},{"subj":"T2432","pred":"source","obj":"biosemtest"},{"subj":"T2433","pred":"source","obj":"biosemtest"},{"subj":"T2434","pred":"source","obj":"biosemtest"},{"subj":"T2435","pred":"source","obj":"biosemtest"},{"subj":"T2436","pred":"source","obj":"biosemtest"},{"subj":"T2437","pred":"source","obj":"biosemtest"},{"subj":"T2438","pred":"source","obj":"biosemtest"},{"subj":"T2439","pred":"source","obj":"biosemtest"},{"subj":"T2440","pred":"source","obj":"biosemtest"},{"subj":"T2441","pred":"source","obj":"biosemtest"},{"subj":"T2442","pred":"source","obj":"biosemtest"},{"subj":"T2443","pred":"source","obj":"biosemtest"},{"subj":"T2444","pred":"source","obj":"biosemtest"},{"subj":"T2445","pred":"source","obj":"biosemtest"},{"subj":"T2446","pred":"source","obj":"biosemtest"},{"subj":"T2447","pred":"source","obj":"biosemtest"},{"subj":"T2448","pred":"source","obj":"biosemtest"},{"subj":"T2449","pred":"source","obj":"biosemtest"},{"subj":"T2450","pred":"source","obj":"biosemtest"},{"subj":"T2451","pred":"source","obj":"biosemtest"},{"subj":"T2452","pred":"source","obj":"biosemtest"},{"subj":"T2453","pred":"source","obj":"biosemtest"},{"subj":"T2454","pred":"source","obj":"biosemtest"},{"subj":"T2455","pred":"source","obj":"biosemtest"},{"subj":"T2456","pred":"source","obj":"biosemtest"},{"subj":"T2457","pred":"source","obj":"biosemtest"},{"subj":"T2458","pred":"source","obj":"biosemtest"},{"subj":"T2459","pred":"source","obj":"biosemtest"},{"subj":"T2460","pred":"source","obj":"biosemtest"},{"subj":"T2461","pred":"source","obj":"biosemtest"},{"subj":"T2462","pred":"source","obj":"biosemtest"},{"subj":"T2463","pred":"source","obj":"biosemtest"},{"subj":"T2464","pred":"source","obj":"biosemtest"},{"subj":"T2465","pred":"source","obj":"biosemtest"},{"subj":"T2466","pred":"source","obj":"biosemtest"},{"subj":"T2467","pred":"source","obj":"biosemtest"},{"subj":"T2468","pred":"source","obj":"biosemtest"},{"subj":"T2469","pred":"source","obj":"biosemtest"},{"subj":"T2470","pred":"source","obj":"biosemtest"},{"subj":"T2471","pred":"source","obj":"biosemtest"},{"subj":"T2472","pred":"source","obj":"biosemtest"},{"subj":"T2473","pred":"source","obj":"biosemtest"},{"subj":"T2474","pred":"source","obj":"biosemtest"},{"subj":"T2475","pred":"source","obj":"biosemtest"},{"subj":"T2476","pred":"source","obj":"biosemtest"},{"subj":"T2477","pred":"source","obj":"biosemtest"},{"subj":"T2478","pred":"source","obj":"biosemtest"},{"subj":"T2479","pred":"source","obj":"biosemtest"},{"subj":"T2480","pred":"source","obj":"biosemtest"},{"subj":"T2481","pred":"source","obj":"biosemtest"},{"subj":"T2482","pred":"source","obj":"biosemtest"},{"subj":"T2483","pred":"source","obj":"biosemtest"},{"subj":"T2484","pred":"source","obj":"biosemtest"},{"subj":"T2485","pred":"source","obj":"biosemtest"},{"subj":"T2486","pred":"source","obj":"biosemtest"},{"subj":"T2487","pred":"source","obj":"biosemtest"},{"subj":"T2488","pred":"source","obj":"biosemtest"},{"subj":"T2489","pred":"source","obj":"biosemtest"},{"subj":"T2490","pred":"source","obj":"biosemtest"},{"subj":"T2491","pred":"source","obj":"biosemtest"},{"subj":"T2492","pred":"source","obj":"biosemtest"},{"subj":"T2493","pred":"source","obj":"biosemtest"},{"subj":"T2494","pred":"source","obj":"biosemtest"},{"subj":"T2495","pred":"source","obj":"biosemtest"},{"subj":"T2496","pred":"source","obj":"biosemtest"},{"subj":"T2497","pred":"source","obj":"biosemtest"},{"subj":"T2498","pred":"source","obj":"biosemtest"},{"subj":"T2499","pred":"source","obj":"biosemtest"},{"subj":"T2500","pred":"source","obj":"biosemtest"},{"subj":"T2501","pred":"source","obj":"biosemtest"},{"subj":"T2524","pred":"source","obj":"biosemtest"},{"subj":"T2525","pred":"source","obj":"biosemtest"},{"subj":"T2526","pred":"source","obj":"biosemtest"},{"subj":"T2527","pred":"source","obj":"biosemtest"},{"subj":"T2528","pred":"source","obj":"biosemtest"},{"subj":"T2529","pred":"source","obj":"biosemtest"},{"subj":"T2530","pred":"source","obj":"biosemtest"},{"subj":"T2531","pred":"source","obj":"biosemtest"},{"subj":"T2532","pred":"source","obj":"biosemtest"},{"subj":"T2533","pred":"source","obj":"biosemtest"},{"subj":"T2534","pred":"source","obj":"biosemtest"},{"subj":"T2535","pred":"source","obj":"biosemtest"},{"subj":"T2536","pred":"source","obj":"biosemtest"},{"subj":"T2537","pred":"source","obj":"biosemtest"},{"subj":"T2538","pred":"source","obj":"biosemtest"},{"subj":"T2539","pred":"source","obj":"biosemtest"},{"subj":"T2540","pred":"source","obj":"biosemtest"},{"subj":"T2541","pred":"source","obj":"biosemtest"},{"subj":"T2542","pred":"source","obj":"biosemtest"},{"subj":"T2543","pred":"source","obj":"biosemtest"},{"subj":"T2544","pred":"source","obj":"biosemtest"},{"subj":"T2545","pred":"source","obj":"biosemtest"},{"subj":"T2546","pred":"source","obj":"biosemtest"},{"subj":"T2547","pred":"source","obj":"biosemtest"},{"subj":"T2548","pred":"source","obj":"biosemtest"},{"subj":"T2549","pred":"source","obj":"biosemtest"},{"subj":"T2550","pred":"source","obj":"biosemtest"},{"subj":"T2551","pred":"source","obj":"biosemtest"},{"subj":"T2552","pred":"source","obj":"biosemtest"},{"subj":"T2553","pred":"source","obj":"biosemtest"},{"subj":"T2554","pred":"source","obj":"biosemtest"},{"subj":"T2555","pred":"source","obj":"biosemtest"},{"subj":"T2556","pred":"source","obj":"biosemtest"},{"subj":"T2557","pred":"source","obj":"biosemtest"},{"subj":"T2558","pred":"source","obj":"biosemtest"},{"subj":"T2559","pred":"source","obj":"biosemtest"},{"subj":"T2560","pred":"source","obj":"biosemtest"},{"subj":"T2561","pred":"source","obj":"biosemtest"},{"subj":"T2562","pred":"source","obj":"biosemtest"},{"subj":"T2563","pred":"source","obj":"biosemtest"},{"subj":"T2564","pred":"source","obj":"biosemtest"},{"subj":"T2565","pred":"source","obj":"biosemtest"},{"subj":"T2570","pred":"source","obj":"biosemtest"},{"subj":"T2571","pred":"source","obj":"biosemtest"},{"subj":"T2572","pred":"source","obj":"biosemtest"},{"subj":"T2573","pred":"source","obj":"biosemtest"},{"subj":"T2574","pred":"source","obj":"biosemtest"},{"subj":"T2575","pred":"source","obj":"biosemtest"},{"subj":"T2576","pred":"source","obj":"biosemtest"},{"subj":"T2577","pred":"source","obj":"biosemtest"},{"subj":"T2578","pred":"source","obj":"biosemtest"},{"subj":"T2579","pred":"source","obj":"biosemtest"},{"subj":"T2580","pred":"source","obj":"biosemtest"},{"subj":"T2581","pred":"source","obj":"biosemtest"},{"subj":"T2582","pred":"source","obj":"biosemtest"},{"subj":"T2583","pred":"source","obj":"biosemtest"},{"subj":"T2584","pred":"source","obj":"biosemtest"},{"subj":"T2585","pred":"source","obj":"biosemtest"},{"subj":"T2586","pred":"source","obj":"biosemtest"},{"subj":"T2587","pred":"source","obj":"biosemtest"},{"subj":"T2588","pred":"source","obj":"biosemtest"},{"subj":"T2589","pred":"source","obj":"biosemtest"},{"subj":"T2590","pred":"source","obj":"biosemtest"},{"subj":"T2591","pred":"source","obj":"biosemtest"},{"subj":"T2592","pred":"source","obj":"biosemtest"},{"subj":"T2603","pred":"source","obj":"biosemtest"},{"subj":"T2604","pred":"source","obj":"biosemtest"},{"subj":"T2605","pred":"source","obj":"biosemtest"},{"subj":"T2606","pred":"source","obj":"biosemtest"},{"subj":"T2607","pred":"source","obj":"biosemtest"},{"subj":"T2608","pred":"source","obj":"biosemtest"},{"subj":"T2609","pred":"source","obj":"biosemtest"},{"subj":"T2610","pred":"source","obj":"biosemtest"},{"subj":"T2611","pred":"source","obj":"biosemtest"},{"subj":"T2612","pred":"source","obj":"biosemtest"},{"subj":"T2613","pred":"source","obj":"biosemtest"},{"subj":"T2614","pred":"source","obj":"biosemtest"},{"subj":"T2615","pred":"source","obj":"biosemtest"},{"subj":"T2616","pred":"source","obj":"biosemtest"},{"subj":"T2617","pred":"source","obj":"biosemtest"},{"subj":"T2618","pred":"source","obj":"biosemtest"},{"subj":"T2619","pred":"source","obj":"biosemtest"}]},{"project":"NEUROSES","denotations":[{"id":"T2513","span":{"begin":11,"end":21},"obj":"CHEBI_63631"},{"id":"T2514","span":{"begin":137,"end":147},"obj":"CHEBI_63631"},{"id":"T2515","span":{"begin":251,"end":261},"obj":"CHEBI_63631"},{"id":"T2516","span":{"begin":341,"end":351},"obj":"CHEBI_63631"},{"id":"T2517","span":{"begin":486,"end":496},"obj":"CHEBI_63631"},{"id":"T2518","span":{"begin":614,"end":620},"obj":"PATO_0000128"},{"id":"T2519","span":{"begin":279,"end":283},"obj":"PATO_0000610"},{"id":"T2520","span":{"begin":284,"end":287},"obj":"CHEBI_40799"},{"id":"T2521","span":{"begin":546,"end":549},"obj":"CHEBI_40799"},{"id":"T2522","span":{"begin":426,"end":431},"obj":"PATO_0000389"},{"id":"T2523","span":{"begin":730,"end":741},"obj":"CHEBI_77966"},{"id":"T2568","span":{"begin":1020,"end":1028},"obj":"PATO_0000173"},{"id":"T2569","span":{"begin":1029,"end":1039},"obj":"CHEBI_63631"},{"id":"T2598","span":{"begin":1216,"end":1227},"obj":"CHEBI_77966"},{"id":"T2599","span":{"begin":1229,"end":1244},"obj":"CHEBI_35623"},{"id":"T2600","span":{"begin":1249,"end":1256},"obj":"CHEBI_30145"},{"id":"T2601","span":{"begin":1249,"end":1256},"obj":"CHEBI_49713"},{"id":"T2602","span":{"begin":1350,"end":1355},"obj":"CHEBI_23888"},{"id":"T2622","span":{"begin":1380,"end":1388},"obj":"PATO_0001627"},{"id":"T2623","span":{"begin":1436,"end":1444},"obj":"PATO_0001627"}],"attributes":[{"subj":"T2513","pred":"source","obj":"NEUROSES"},{"subj":"T2514","pred":"source","obj":"NEUROSES"},{"subj":"T2515","pred":"source","obj":"NEUROSES"},{"subj":"T2516","pred":"source","obj":"NEUROSES"},{"subj":"T2517","pred":"source","obj":"NEUROSES"},{"subj":"T2518","pred":"source","obj":"NEUROSES"},{"subj":"T2519","pred":"source","obj":"NEUROSES"},{"subj":"T2520","pred":"source","obj":"NEUROSES"},{"subj":"T2521","pred":"source","obj":"NEUROSES"},{"subj":"T2522","pred":"source","obj":"NEUROSES"},{"subj":"T2523","pred":"source","obj":"NEUROSES"},{"subj":"T2568","pred":"source","obj":"NEUROSES"},{"subj":"T2569","pred":"source","obj":"NEUROSES"},{"subj":"T2598","pred":"source","obj":"NEUROSES"},{"subj":"T2599","pred":"source","obj":"NEUROSES"},{"subj":"T2600","pred":"source","obj":"NEUROSES"},{"subj":"T2601","pred":"source","obj":"NEUROSES"},{"subj":"T2602","pred":"source","obj":"NEUROSES"},{"subj":"T2622","pred":"source","obj":"NEUROSES"},{"subj":"T2623","pred":"source","obj":"NEUROSES"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"biosemtest","color":"#caec93","default":true},{"id":"NEUROSES","color":"#ec93e4"}]}]}}