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medication\nThe nine treatment resistant/incomplete responder patients took combinations of medications: all of them took antidepressants, seven took antipsychotics, five took lithium and five took anticonvulsants (Table 1). One other patient was in a full remission on lithium monotherapy and one had recently been discharged from hospital after a manic relapse, having been relatively stable for several years prior to that. In four cases an anticonvulsant was exchanged with topiramate, in the remaining cases topiramate was given as an add-on treatment. No one received monotherapy of topiramate.\nTable 1 Characteristics of the patients and changes of their weight during the study. Both individual and mean weight changes are presented. p-values are based on paired samples tests for the patients who have completed the corresponding follow-up interval. The dose of topiramate is the highest dose reached. Under \"Concomitant medication\" the drugs that are undelined were exchanged with topiramate.\n\nT"}

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