PMC:1087494 / 116-696 JSONTXT

{"project":"biosemtest","denotations":[{"id":"T3","span":{"begin":428,"end":438},"obj":"UMLS/C1882979"},{"id":"T14","span":{"begin":205,"end":212},"obj":"UMLS/C1709908"},{"id":"T15","span":{"begin":27,"end":33},"obj":"UMLS/C1314792"},{"id":"T16","span":{"begin":72,"end":77},"obj":"UMLS/C1314792"},{"id":"T17","span":{"begin":259,"end":265},"obj":"UMLS/C1314792"},{"id":"T18","span":{"begin":297,"end":303},"obj":"UMLS/C1522242"},{"id":"T19","span":{"begin":498,"end":500},"obj":"UMLS/C0319022"},{"id":"T25","span":{"begin":417,"end":420},"obj":"UMLS/C0005341"},{"id":"T26","span":{"begin":82,"end":97},"obj":"UMLS/C0032646"},{"id":"T30","span":{"begin":368,"end":378},"obj":"UMLS/C1705532"},{"id":"T38","span":{"begin":248,"end":258},"obj":"UMLS/C0076829"},{"id":"T39","span":{"begin":487,"end":497},"obj":"UMLS/C0076829"},{"id":"T50","span":{"begin":297,"end":303},"obj":"UMLS/C1561557"},{"id":"T55","span":{"begin":160,"end":169},"obj":"UMLS/C0026538"},{"id":"T56","span":{"begin":66,"end":71},"obj":"UMLS/C0205164"},{"id":"T58","span":{"begin":198,"end":204},"obj":"UMLS/C0332185"},{"id":"T63","span":{"begin":27,"end":33},"obj":"UMLS/C0678227"},{"id":"T64","span":{"begin":72,"end":77},"obj":"UMLS/C0678227"},{"id":"T65","span":{"begin":259,"end":265},"obj":"UMLS/C0678227"},{"id":"T70","span":{"begin":289,"end":296},"obj":"UMLS/C1578485"},{"id":"T71","span":{"begin":382,"end":390},"obj":"UMLS/C1578485"},{"id":"T72","span":{"begin":510,"end":518},"obj":"UMLS/C1578485"},{"id":"T83","span":{"begin":289,"end":296},"obj":"UMLS/C1578484"},{"id":"T84","span":{"begin":382,"end":390},"obj":"UMLS/C1578484"},{"id":"T85","span":{"begin":510,"end":518},"obj":"UMLS/C1578484"},{"id":"T97","span":{"begin":266,"end":277},"obj":"UMLS/C0043096"},{"id":"T100","span":{"begin":289,"end":296},"obj":"UMLS/C1578486"},{"id":"T101","span":{"begin":382,"end":390},"obj":"UMLS/C1578486"},{"id":"T102","span":{"begin":510,"end":518},"obj":"UMLS/C1578486"},{"id":"T112","span":{"begin":289,"end":296},"obj":"UMLS/C1578481"},{"id":"T113","span":{"begin":382,"end":390},"obj":"UMLS/C1578481"},{"id":"T114","span":{"begin":510,"end":518},"obj":"UMLS/C1578481"},{"id":"T123","span":{"begin":27,"end":33},"obj":"UMLS/C1524003"},{"id":"T124","span":{"begin":72,"end":77},"obj":"UMLS/C1524003"},{"id":"T125","span":{"begin":259,"end":265},"obj":"UMLS/C1524003"},{"id":"T130","span":{"begin":289,"end":296},"obj":"UMLS/C1578480"},{"id":"T131","span":{"begin":382,"end":390},"obj":"UMLS/C1578480"},{"id":"T132","span":{"begin":510,"end":518},"obj":"UMLS/C1578480"},{"id":"T142","span":{"begin":289,"end":296},"obj":"UMLS/C1578483"},{"id":"T143","span":{"begin":382,"end":390},"obj":"UMLS/C1578483"},{"id":"T144","span":{"begin":510,"end":518},"obj":"UMLS/C1578483"},{"id":"T157","span":{"begin":289,"end":296},"obj":"UMLS/C1578479"},{"id":"T158","span":{"begin":382,"end":390},"obj":"UMLS/C1578479"},{"id":"T159","span":{"begin":510,"end":518},"obj":"UMLS/C1578479"},{"id":"T170","span":{"begin":160,"end":169},"obj":"UMLS/C0220880"},{"id":"T171","span":{"begin":176,"end":196},"obj":"UMLS/C0748064"},{"id":"T172","span":{"begin":363,"end":367},"obj":"UMLS/C2713234"},{"id":"T181","span":{"begin":289,"end":296},"obj":"UMLS/C0030705"},{"id":"T182","span":{"begin":382,"end":390},"obj":"UMLS/C0030705"},{"id":"T183","span":{"begin":510,"end":518},"obj":"UMLS/C0030705"},{"id":"T195","span":{"begin":428,"end":438},"obj":"UMLS/C0009932"},{"id":"T196","span":{"begin":297,"end":303},"obj":"UMLS/C1552516"},{"id":"T210","span":{"begin":351,"end":357},"obj":"UMLS/C0008976"},{"id":"T211","span":{"begin":439,"end":445},"obj":"UMLS/C0008976"},{"id":"T212","span":{"begin":329,"end":342},"obj":"UMLS/C1280519"},{"id":"T214","span":{"begin":297,"end":303},"obj":"UMLS/C0441833"},{"id":"T219","span":{"begin":501,"end":506},"obj":"UMLS/C1292734"},{"id":"T232","span":{"begin":309,"end":313},"obj":"UMLS/C1254351"},{"id":"T233","span":{"begin":42,"end":60},"obj":"UMLS/C0033978"},{"id":"T234","span":{"begin":564,"end":569},"obj":"UMLS/C0918012"},{"id":"T237","span":{"begin":428,"end":438},"obj":"UMLS/C1550141"},{"id":"T241","span":{"begin":564,"end":569},"obj":"UMLS/C1637833"},{"id":"T242","span":{"begin":574,"end":579},"obj":"UMLS/C0456689"},{"id":"T243","span":{"begin":135,"end":143},"obj":"UMLS/C0442808"},{"id":"T244","span":{"begin":135,"end":143},"obj":"UMLS/C0442805"},{"id":"T247","span":{"begin":27,"end":33},"obj":"UMLS/C0015127"},{"id":"T248","span":{"begin":72,"end":77},"obj":"UMLS/C0015127"},{"id":"T249","span":{"begin":259,"end":265},"obj":"UMLS/C0015127"},{"id":"T250","span":{"begin":314,"end":317},"obj":"UMLS/C2348947"},{"id":"T252","span":{"begin":108,"end":119},"obj":"UMLS/C0802604"},{"id":"T257","span":{"begin":37,"end":41},"obj":"UMLS/C0439064"},{"id":"T258","span":{"begin":108,"end":119},"obj":"UMLS/C2598133"},{"id":"T261","span":{"begin":0,"end":10},"obj":"UMLS/C1706907"},{"id":"T264","span":{"begin":564,"end":569},"obj":"UMLS/C1552854"},{"id":"T266","span":{"begin":564,"end":569},"obj":"UMLS/C0600653"},{"id":"T267","span":{"begin":428,"end":438},"obj":"UMLS/C1547100"},{"id":"T269","span":{"begin":297,"end":303},"obj":"UMLS/C1257890"},{"id":"T271","span":{"begin":297,"end":303},"obj":"UMLS/C1552839"},{"id":"T273","span":{"begin":289,"end":296},"obj":"UMLS/C1550655"},{"id":"T274","span":{"begin":382,"end":390},"obj":"UMLS/C1550655"},{"id":"T275","span":{"begin":510,"end":518},"obj":"UMLS/C1550655"},{"id":"T288","span":{"begin":453,"end":468},"obj":"UMLS/C0520010"},{"id":"T289","span":{"begin":108,"end":119},"obj":"UMLS/C0013227"},{"id":"T290","span":{"begin":309,"end":313},"obj":"UMLS/C0013227"},{"id":"T293","span":{"begin":124,"end":129},"obj":"UMLS/C0006823"},{"id":"T296","span":{"begin":368,"end":378},"obj":"UMLS/C1550603"},{"id":"T303","span":{"begin":176,"end":196},"obj":"UMLS/C1549593"},{"id":"T304","span":{"begin":124,"end":129},"obj":"UMLS/C0344312"},{"id":"T311","span":{"begin":428,"end":438},"obj":"UMLS/C0243148"},{"id":"T312","span":{"begin":297,"end":303},"obj":"UMLS/C0439745"},{"id":"T313","span":{"begin":346,"end":350},"obj":"UMLS/C1882151"},{"id":"T318","span":{"begin":135,"end":143},"obj":"UMLS/C0205217"},{"id":"T320","span":{"begin":205,"end":212},"obj":"UMLS/C0700287"},{"id":"T326","span":{"begin":346,"end":350},"obj":"UMLS/C0175566"},{"id":"T327","span":{"begin":564,"end":569},"obj":"UMLS/C0021200"},{"id":"T331","span":{"begin":363,"end":367},"obj":"UMLS/C0026516"},{"id":"T333","span":{"begin":501,"end":506},"obj":"UMLS/C0332293"},{"id":"T335","span":{"begin":396,"end":415},"obj":"UMLS/C0525045"},{"id":"T336","span":{"begin":524,"end":543},"obj":"UMLS/C0525045"},{"id":"T337","span":{"begin":297,"end":303},"obj":"UMLS/C1705428"},{"id":"T338","span":{"begin":297,"end":303},"obj":"UMLS/C1705429"},{"id":"T342","span":{"begin":289,"end":296},"obj":"UMLS/C1705908"},{"id":"T343","span":{"begin":382,"end":390},"obj":"UMLS/C1705908"},{"id":"T344","span":{"begin":510,"end":518},"obj":"UMLS/C1705908"},{"id":"T353","span":{"begin":428,"end":438},"obj":"UMLS/C0332298"},{"id":"T360","span":{"begin":421,"end":424},"obj":"UMLS/C1518422"},{"id":"T362","span":{"begin":233,"end":247},"obj":"UMLS/C0003286"},{"id":"T371","span":{"begin":501,"end":506},"obj":"UMLS/C1522326"},{"id":"T374","span":{"begin":472,"end":477},"obj":"UMLS/C0338831"},{"id":"T379","span":{"begin":368,"end":378},"obj":"UMLS/C0920880"},{"id":"T382","span":{"begin":428,"end":438},"obj":"UMLS/C2587213"}],"text":"Background\nThe weight-gain caused by many psychotropic drugs is a major cause for poor compliance with such medications and could also increase cardio-vascular morbidity among psychiatric patients. Recent reports have shown that the anticonvulsant topiramate causes weight loss in various patient groups. The drug has also shown effectiveness in open trials as a mood stabilizer in patients with affective disorders, but not in controlled trials in the acute treatment of mania. We used topiramate to treat 12 patients with affective disorders who had a body-mass index \u003e30 kg/m2."}

{"project":"NEUROSES","denotations":[{"id":"T423","span":{"begin":248,"end":258},"obj":"CHEBI_63631"},{"id":"T424","span":{"begin":487,"end":497},"obj":"CHEBI_63631"},{"id":"T431","span":{"begin":15,"end":21},"obj":"PATO_0000128"},{"id":"T432","span":{"begin":266,"end":272},"obj":"PATO_0000128"},{"id":"T438","span":{"begin":160,"end":169},"obj":"PATO_0001415"},{"id":"T439","span":{"begin":198,"end":204},"obj":"PATO_0001484"},{"id":"T440","span":{"begin":233,"end":247},"obj":"CHEBI_35623"},{"id":"T441","span":{"begin":309,"end":313},"obj":"CHEBI_23888"},{"id":"T442","span":{"begin":346,"end":350},"obj":"PATO_0000610"},{"id":"T443","span":{"begin":368,"end":378},"obj":"CHEBI_77966"},{"id":"T445","span":{"begin":453,"end":458},"obj":"PATO_0000389"},{"id":"T446","span":{"begin":559,"end":563},"obj":"PATO_0000125"}],"text":"Background\nThe weight-gain caused by many psychotropic drugs is a major cause for poor compliance with such medications and could also increase cardio-vascular morbidity among psychiatric patients. Recent reports have shown that the anticonvulsant topiramate causes weight loss in various patient groups. The drug has also shown effectiveness in open trials as a mood stabilizer in patients with affective disorders, but not in controlled trials in the acute treatment of mania. We used topiramate to treat 12 patients with affective disorders who had a body-mass index \u003e30 kg/m2."}