PMC:1087494 / 1016-1507 JSONTXT

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was effective in reducing the weight in 10 out of the 12 patients. At six months the 12 patients had lost a mean of 7.75 kg (SD = 6.9 kg, p \u003c 0.001) and at 12 months 9 patients had lost a mean of 9.61 kg (SD = 6.7 kg, p = 0.003). Three patients stopped the treatment: one due to side effects, one due to possible side effects, and one suffered a manic relapse and showed no sustained weight loss. There were no other clear changes in the course of illness of the patients."}

{"project":"NEUROSES","denotations":[{"id":"T427","span":{"begin":8,"end":18},"obj":"CHEBI_63631"},{"id":"T434","span":{"begin":49,"end":55},"obj":"PATO_0000128"},{"id":"T435","span":{"begin":403,"end":409},"obj":"PATO_0000128"},{"id":"T447","span":{"begin":120,"end":124},"obj":"CHEBI_25434"},{"id":"T448","span":{"begin":200,"end":204},"obj":"CHEBI_25434"},{"id":"T449","span":{"begin":436,"end":441},"obj":"PATO_0000964"}],"text":"Results\nTopiramate was effective in reducing the weight in 10 out of the 12 patients. At six months the 12 patients had lost a mean of 7.75 kg (SD = 6.9 kg, p \u003c 0.001) and at 12 months 9 patients had lost a mean of 9.61 kg (SD = 6.7 kg, p = 0.003). Three patients stopped the treatment: one due to side effects, one due to possible side effects, and one suffered a manic relapse and showed no sustained weight loss. There were no other clear changes in the course of illness of the patients."}