Id |
Subject |
Object |
Predicate |
Lexical cue |
T3622 |
0-2 |
PRP |
denotes |
We |
T3623 |
9-16 |
VBD |
denotes |
defined |
T3624 |
3-8 |
RB |
denotes |
first |
T3625 |
17-19 |
DT |
denotes |
an |
T3626 |
38-47 |
NN |
denotes |
regulator |
T3627 |
20-23 |
NN |
denotes |
ETS |
T3628 |
24-37 |
NN |
denotes |
transcription |
T3629 |
48-52 |
WDT |
denotes |
that |
T3630 |
53-55 |
VBZ |
denotes |
is |
T3631 |
56-60 |
JJ |
denotes |
able |
T3632 |
61-63 |
TO |
denotes |
to |
T3633 |
64-71 |
VB |
denotes |
replace |
T3634 |
72-75 |
DT |
denotes |
the |
T3635 |
76-84 |
NN |
denotes |
function |
T3636 |
85-87 |
IN |
denotes |
of |
T3637 |
88-92 |
NN |
denotes |
Er81 |
T3638 |
93-99 |
IN |
denotes |
within |
T3639 |
100-114 |
JJ |
denotes |
proprioceptive |
T3640 |
115-124 |
NNS |
denotes |
afferents |
T3641 |
125-127 |
TO |
denotes |
to |
T3642 |
128-134 |
VB |
denotes |
direct |
T3643 |
135-146 |
NNS |
denotes |
projections |
T3644 |
147-151 |
IN |
denotes |
into |
T3645 |
152-155 |
DT |
denotes |
the |
T3646 |
171-175 |
NN |
denotes |
cord |
T3647 |
156-163 |
JJ |
denotes |
ventral |
T3648 |
164-170 |
JJ |
denotes |
spinal |
T3649 |
175-176 |
. |
denotes |
. |
T3650 |
176-357 |
sentence |
denotes |
Er81, Pea3, and Erm constitute the Pea3 subfamily of ETS transcription factors, show a high degree of amino acid identity, and bind to very similar DNA target sequences [17,18,19]. |
T3651 |
177-181 |
NN |
denotes |
Er81 |
T3652 |
197-207 |
VBP |
denotes |
constitute |
T3653 |
181-183 |
, |
denotes |
, |
T3654 |
183-187 |
NN |
denotes |
Pea3 |
T3655 |
187-189 |
, |
denotes |
, |
T3656 |
189-192 |
CC |
denotes |
and |
T3657 |
193-196 |
NN |
denotes |
Erm |
T3658 |
208-211 |
DT |
denotes |
the |
T3659 |
217-226 |
NN |
denotes |
subfamily |
T3660 |
212-216 |
NN |
denotes |
Pea3 |
T3661 |
227-229 |
IN |
denotes |
of |
T3662 |
230-233 |
NN |
denotes |
ETS |
T3663 |
248-255 |
NNS |
denotes |
factors |
T3664 |
234-247 |
NN |
denotes |
transcription |
T3665 |
255-257 |
, |
denotes |
, |
T3666 |
257-261 |
VBP |
denotes |
show |
T3667 |
262-263 |
DT |
denotes |
a |
T3668 |
269-275 |
NN |
denotes |
degree |
T3669 |
264-268 |
JJ |
denotes |
high |
T3670 |
276-278 |
IN |
denotes |
of |
T3671 |
279-284 |
NN |
denotes |
amino |
T3672 |
285-289 |
NN |
denotes |
acid |
T3673 |
290-298 |
NN |
denotes |
identity |
T3674 |
298-300 |
, |
denotes |
, |
T3675 |
300-303 |
CC |
denotes |
and |
T3676 |
304-308 |
VBP |
denotes |
bind |
T3677 |
309-311 |
IN |
denotes |
to |
T3678 |
312-316 |
RB |
denotes |
very |
T3679 |
317-324 |
JJ |
denotes |
similar |
T3680 |
336-345 |
NNS |
denotes |
sequences |
T3681 |
325-328 |
NN |
denotes |
DNA |
T3682 |
329-335 |
NN |
denotes |
target |
T3683 |
346-347 |
-LRB- |
denotes |
[ |
T3684 |
353-355 |
CD |
denotes |
19 |
T3685 |
347-349 |
CD |
denotes |
17 |
T3686 |
349-350 |
, |
denotes |
, |
T3687 |
350-352 |
CD |
denotes |
18 |
T3688 |
352-353 |
, |
denotes |
, |
T3689 |
355-356 |
-RRB- |
denotes |
] |
T3690 |
356-357 |
. |
denotes |
. |
T3691 |
357-631 |
sentence |
denotes |
Nevertheless, when introduced into the Er81 locus in analogy to a previously used targeting strategy (data not shown; [14]), neither Pea3 nor Erm could rescue Ia proprioceptive afferent projections to extensively invade the ventral horn of the spinal cord (data not shown). |
T3692 |
358-370 |
RB |
denotes |
Nevertheless |
T3693 |
510-516 |
VB |
denotes |
rescue |
T3694 |
370-372 |
, |
denotes |
, |
T3695 |
372-376 |
WRB |
denotes |
when |
T3696 |
377-387 |
VBN |
denotes |
introduced |
T3697 |
388-392 |
IN |
denotes |
into |
T3698 |
393-396 |
DT |
denotes |
the |
T3699 |
402-407 |
NN |
denotes |
locus |
T3700 |
397-401 |
NN |
denotes |
Er81 |
T3701 |
408-410 |
IN |
denotes |
in |
T3702 |
411-418 |
NN |
denotes |
analogy |
T3703 |
419-421 |
IN |
denotes |
to |
T3704 |
422-423 |
DT |
denotes |
a |
T3705 |
450-458 |
NN |
denotes |
strategy |
T3706 |
424-434 |
RB |
denotes |
previously |
T3707 |
435-439 |
VBN |
denotes |
used |
T3708 |
440-449 |
NN |
denotes |
targeting |
T3709 |
459-460 |
-LRB- |
denotes |
( |
T3710 |
469-474 |
VBN |
denotes |
shown |
T3711 |
460-464 |
NNS |
denotes |
data |
T3712 |
465-468 |
RB |
denotes |
not |
T3713 |
474-475 |
: |
denotes |
; |
T3714 |
476-477 |
-LRB- |
denotes |
[ |
T3715 |
477-479 |
CD |
denotes |
14 |
T3716 |
479-480 |
-RRB- |
denotes |
] |
T3717 |
480-481 |
-RRB- |
denotes |
) |
T3718 |
481-483 |
, |
denotes |
, |
T3719 |
483-490 |
CC |
denotes |
neither |
T3720 |
491-495 |
NN |
denotes |
Pea3 |
T3721 |
496-499 |
CC |
denotes |
nor |
T3722 |
500-503 |
NN |
denotes |
Erm |
T3723 |
504-509 |
MD |
denotes |
could |
T3724 |
517-519 |
NN |
denotes |
Ia |
T3725 |
520-534 |
JJ |
denotes |
proprioceptive |
T3726 |
544-555 |
NNS |
denotes |
projections |
T3727 |
535-543 |
JJ |
denotes |
afferent |
T3728 |
556-558 |
TO |
denotes |
to |
T3729 |
571-577 |
VB |
denotes |
invade |
T3730 |
559-570 |
RB |
denotes |
extensively |
T3731 |
578-581 |
DT |
denotes |
the |
T3732 |
590-594 |
NN |
denotes |
horn |
T3733 |
582-589 |
JJ |
denotes |
ventral |
T3734 |
595-597 |
IN |
denotes |
of |
T3735 |
598-601 |
DT |
denotes |
the |
T3736 |
609-613 |
NN |
denotes |
cord |
T3737 |
602-608 |
JJ |
denotes |
spinal |
T3738 |
614-615 |
-LRB- |
denotes |
( |
T3739 |
624-629 |
VBN |
denotes |
shown |
T3740 |
615-619 |
NNS |
denotes |
data |
T3741 |
620-623 |
RB |
denotes |
not |
T3742 |
629-630 |
-RRB- |
denotes |
) |
T3743 |
630-631 |
. |
denotes |
. |
T3744 |
631-875 |
sentence |
denotes |
These findings prompted us to analyze mice in which we integrated EWS-Pea3, a break-point fusion product between the amino-terminal domain of the Ewing sarcoma (EWS) gene and the Pea3 DNA binding domain [20,21], into the Er81 locus (Figure 1). |
T3745 |
632-637 |
DT |
denotes |
These |
T3746 |
638-646 |
NNS |
denotes |
findings |
T3747 |
647-655 |
VBD |
denotes |
prompted |
T3748 |
656-658 |
PRP |
denotes |
us |
T3749 |
659-661 |
TO |
denotes |
to |
T3750 |
662-669 |
VB |
denotes |
analyze |
T3751 |
670-674 |
NNS |
denotes |
mice |
T3752 |
675-677 |
IN |
denotes |
in |
T3753 |
687-697 |
VBD |
denotes |
integrated |
T3754 |
678-683 |
WDT |
denotes |
which |
T3755 |
684-686 |
PRP |
denotes |
we |
T3756 |
698-701 |
NN |
denotes |
EWS |
T3757 |
702-706 |
NN |
denotes |
Pea3 |
T3758 |
701-702 |
HYPH |
denotes |
- |
T3759 |
706-708 |
, |
denotes |
, |
T3760 |
708-709 |
DT |
denotes |
a |
T3761 |
729-736 |
NN |
denotes |
product |
T3762 |
710-715 |
NN |
denotes |
break |
T3763 |
716-721 |
NN |
denotes |
point |
T3764 |
715-716 |
HYPH |
denotes |
- |
T3765 |
722-728 |
NN |
denotes |
fusion |
T3766 |
737-744 |
IN |
denotes |
between |
T3767 |
745-748 |
DT |
denotes |
the |
T3768 |
764-770 |
NN |
denotes |
domain |
T3769 |
749-754 |
NN |
denotes |
amino |
T3770 |
755-763 |
JJ |
denotes |
terminal |
T3771 |
754-755 |
HYPH |
denotes |
- |
T3772 |
771-773 |
IN |
denotes |
of |
T3773 |
774-777 |
DT |
denotes |
the |
T3774 |
798-802 |
NN |
denotes |
gene |
T3775 |
778-783 |
NN |
denotes |
Ewing |
T3776 |
784-791 |
NN |
denotes |
sarcoma |
T3777 |
792-793 |
-LRB- |
denotes |
( |
T3778 |
793-796 |
NN |
denotes |
EWS |
T3779 |
796-797 |
-RRB- |
denotes |
) |
T3780 |
803-806 |
CC |
denotes |
and |
T3781 |
807-810 |
DT |
denotes |
the |
T3782 |
828-834 |
NN |
denotes |
domain |
T3783 |
811-815 |
NN |
denotes |
Pea3 |
T3784 |
816-819 |
NN |
denotes |
DNA |
T3785 |
820-827 |
VBG |
denotes |
binding |
T3786 |
835-836 |
-LRB- |
denotes |
[ |
T3787 |
839-841 |
CD |
denotes |
21 |
T3788 |
836-838 |
CD |
denotes |
20 |
T3789 |
838-839 |
, |
denotes |
, |
T3790 |
841-842 |
-RRB- |
denotes |
] |
T3791 |
842-844 |
, |
denotes |
, |
T3792 |
844-848 |
IN |
denotes |
into |
T3793 |
849-852 |
DT |
denotes |
the |
T3794 |
858-863 |
NN |
denotes |
locus |
T3795 |
853-857 |
NN |
denotes |
Er81 |
T3796 |
864-865 |
-LRB- |
denotes |
( |
T3797 |
865-871 |
NN |
denotes |
Figure |
T3798 |
872-873 |
CD |
denotes |
1 |
T3799 |
873-874 |
-RRB- |
denotes |
) |
T3800 |
874-875 |
. |
denotes |
. |
T3801 |
875-1095 |
sentence |
denotes |
We found that in a luciferase-enzyme-based cell culture transfection assay, EWS-Pea3 showed stronger transactivation activity than Er81 or Pea3 (Figure 1J; data not shown), in agreement with previous studies [22,23,24]. |
T3802 |
876-878 |
PRP |
denotes |
We |
T3803 |
879-884 |
VBD |
denotes |
found |
T3804 |
885-889 |
IN |
denotes |
that |
T3805 |
961-967 |
VBD |
denotes |
showed |
T3806 |
890-892 |
IN |
denotes |
in |
T3807 |
893-894 |
DT |
denotes |
a |
T3808 |
945-950 |
NN |
denotes |
assay |
T3809 |
895-905 |
NN |
denotes |
luciferase |
T3810 |
906-912 |
NN |
denotes |
enzyme |
T3811 |
905-906 |
HYPH |
denotes |
- |
T3812 |
913-918 |
VBN |
denotes |
based |
T3813 |
912-913 |
HYPH |
denotes |
- |
T3814 |
919-923 |
NN |
denotes |
cell |
T3815 |
924-931 |
NN |
denotes |
culture |
T3816 |
932-944 |
NN |
denotes |
transfection |
T3817 |
950-952 |
, |
denotes |
, |
T3818 |
952-955 |
NN |
denotes |
EWS |
T3819 |
956-960 |
NN |
denotes |
Pea3 |
T3820 |
955-956 |
HYPH |
denotes |
- |
T3821 |
968-976 |
JJR |
denotes |
stronger |
T3822 |
993-1001 |
NN |
denotes |
activity |
T3823 |
977-992 |
NN |
denotes |
transactivation |
T3824 |
1002-1006 |
IN |
denotes |
than |
T3825 |
1007-1011 |
NN |
denotes |
Er81 |
T3826 |
1012-1014 |
CC |
denotes |
or |
T3827 |
1015-1019 |
NN |
denotes |
Pea3 |
T3828 |
1020-1021 |
-LRB- |
denotes |
( |
T3829 |
1028-1030 |
NN |
denotes |
1J |
T3830 |
1021-1027 |
NN |
denotes |
Figure |
T3831 |
1030-1031 |
: |
denotes |
; |
T3832 |
1032-1036 |
NNS |
denotes |
data |
T3833 |
1041-1046 |
VBN |
denotes |
shown |
T3834 |
1037-1040 |
RB |
denotes |
not |
T3835 |
1046-1047 |
-RRB- |
denotes |
) |
T3836 |
1047-1049 |
, |
denotes |
, |
T3837 |
1049-1051 |
IN |
denotes |
in |
T3838 |
1052-1061 |
NN |
denotes |
agreement |
T3839 |
1062-1066 |
IN |
denotes |
with |
T3840 |
1067-1075 |
JJ |
denotes |
previous |
T3841 |
1076-1083 |
NNS |
denotes |
studies |
T3842 |
1084-1085 |
-LRB- |
denotes |
[ |
T3843 |
1091-1093 |
CD |
denotes |
24 |
T3844 |
1085-1087 |
CD |
denotes |
22 |
T3845 |
1087-1088 |
, |
denotes |
, |
T3846 |
1088-1090 |
CD |
denotes |
23 |
T3847 |
1090-1091 |
, |
denotes |
, |
T3848 |
1093-1094 |
-RRB- |
denotes |
] |
T3849 |
1094-1095 |
. |
denotes |
. |
T3850 |
1095-1265 |
sentence |
denotes |
Moreover, transactivation by EWS-Pea3 was abolished by mutation of ETS-binding sites in the reporter plasmid, demonstrating ETS-binding-site dependence (data not shown). |
T3851 |
1096-1104 |
RB |
denotes |
Moreover |
T3852 |
1138-1147 |
VBN |
denotes |
abolished |
T3853 |
1104-1106 |
, |
denotes |
, |
T3854 |
1106-1121 |
NN |
denotes |
transactivation |
T3855 |
1122-1124 |
IN |
denotes |
by |
T3856 |
1125-1128 |
NN |
denotes |
EWS |
T3857 |
1129-1133 |
NN |
denotes |
Pea3 |
T3858 |
1128-1129 |
HYPH |
denotes |
- |
T3859 |
1134-1137 |
VBD |
denotes |
was |
T3860 |
1148-1150 |
IN |
denotes |
by |
T3861 |
1151-1159 |
NN |
denotes |
mutation |
T3862 |
1160-1162 |
IN |
denotes |
of |
T3863 |
1163-1166 |
NN |
denotes |
ETS |
T3864 |
1167-1174 |
VBG |
denotes |
binding |
T3865 |
1166-1167 |
HYPH |
denotes |
- |
T3866 |
1175-1180 |
NNS |
denotes |
sites |
T3867 |
1181-1183 |
IN |
denotes |
in |
T3868 |
1184-1187 |
DT |
denotes |
the |
T3869 |
1197-1204 |
NN |
denotes |
plasmid |
T3870 |
1188-1196 |
NN |
denotes |
reporter |
T3871 |
1204-1206 |
, |
denotes |
, |
T3872 |
1206-1219 |
VBG |
denotes |
demonstrating |
T3873 |
1220-1223 |
NN |
denotes |
ETS |
T3874 |
1224-1231 |
VBG |
denotes |
binding |
T3875 |
1223-1224 |
HYPH |
denotes |
- |
T3876 |
1232-1236 |
NN |
denotes |
site |
T3877 |
1231-1232 |
HYPH |
denotes |
- |
T3878 |
1237-1247 |
NN |
denotes |
dependence |
T3879 |
1248-1249 |
-LRB- |
denotes |
( |
T3880 |
1258-1263 |
VBN |
denotes |
shown |
T3881 |
1249-1253 |
NNS |
denotes |
data |
T3882 |
1254-1257 |
RB |
denotes |
not |
T3883 |
1263-1264 |
-RRB- |
denotes |
) |
T3884 |
1264-1265 |
. |
denotes |
. |
R1010 |
T3622 |
T3623 |
nsubj |
We,defined |
R1011 |
T3624 |
T3623 |
advmod |
first,defined |
R1012 |
T3625 |
T3626 |
det |
an,regulator |
R1013 |
T3626 |
T3623 |
dobj |
regulator,defined |
R1014 |
T3627 |
T3626 |
compound |
ETS,regulator |
R1015 |
T3628 |
T3626 |
compound |
transcription,regulator |
R1016 |
T3629 |
T3630 |
dep |
that,is |
R1017 |
T3630 |
T3626 |
relcl |
is,regulator |
R1018 |
T3631 |
T3630 |
acomp |
able,is |
R1019 |
T3632 |
T3633 |
aux |
to,replace |
R1020 |
T3633 |
T3631 |
xcomp |
replace,able |
R1021 |
T3634 |
T3635 |
det |
the,function |
R1022 |
T3635 |
T3633 |
dobj |
function,replace |
R1023 |
T3636 |
T3635 |
prep |
of,function |
R1024 |
T3637 |
T3636 |
pobj |
Er81,of |
R1025 |
T3638 |
T3635 |
prep |
within,function |
R1026 |
T3639 |
T3640 |
amod |
proprioceptive,afferents |
R1027 |
T3640 |
T3638 |
pobj |
afferents,within |
R1028 |
T3641 |
T3642 |
aux |
to,direct |
R1029 |
T3642 |
T3633 |
advcl |
direct,replace |
R1030 |
T3643 |
T3642 |
dobj |
projections,direct |
R1031 |
T3644 |
T3642 |
prep |
into,direct |
R1032 |
T3645 |
T3646 |
det |
the,cord |
R1033 |
T3646 |
T3644 |
pobj |
cord,into |
R1034 |
T3647 |
T3646 |
amod |
ventral,cord |
R1035 |
T3648 |
T3646 |
amod |
spinal,cord |
R1036 |
T3649 |
T3623 |
punct |
.,defined |
R1037 |
T3651 |
T3652 |
nsubj |
Er81,constitute |
R1038 |
T3653 |
T3651 |
punct |
", ",Er81 |
R1039 |
T3654 |
T3651 |
conj |
Pea3,Er81 |
R1040 |
T3655 |
T3654 |
punct |
", ",Pea3 |
R1041 |
T3656 |
T3654 |
cc |
and,Pea3 |
R1042 |
T3657 |
T3654 |
conj |
Erm,Pea3 |
R1043 |
T3658 |
T3659 |
det |
the,subfamily |
R1044 |
T3659 |
T3652 |
dobj |
subfamily,constitute |
R1045 |
T3660 |
T3659 |
compound |
Pea3,subfamily |
R1046 |
T3661 |
T3659 |
prep |
of,subfamily |
R1047 |
T3662 |
T3663 |
compound |
ETS,factors |
R1048 |
T3663 |
T3661 |
pobj |
factors,of |
R1049 |
T3664 |
T3663 |
compound |
transcription,factors |
R1050 |
T3665 |
T3652 |
punct |
", ",constitute |
R1051 |
T3666 |
T3652 |
conj |
show,constitute |
R1052 |
T3667 |
T3668 |
det |
a,degree |
R1053 |
T3668 |
T3666 |
dobj |
degree,show |
R1054 |
T3669 |
T3668 |
amod |
high,degree |
R1055 |
T3670 |
T3668 |
prep |
of,degree |
R1056 |
T3671 |
T3672 |
compound |
amino,acid |
R1057 |
T3672 |
T3673 |
compound |
acid,identity |
R1058 |
T3673 |
T3670 |
pobj |
identity,of |
R1059 |
T3674 |
T3666 |
punct |
", ",show |
R1060 |
T3675 |
T3666 |
cc |
and,show |
R1061 |
T3676 |
T3666 |
conj |
bind,show |
R1062 |
T3677 |
T3676 |
prep |
to,bind |
R1063 |
T3678 |
T3679 |
advmod |
very,similar |
R1064 |
T3679 |
T3680 |
amod |
similar,sequences |
R1065 |
T3680 |
T3677 |
pobj |
sequences,to |
R1066 |
T3681 |
T3680 |
compound |
DNA,sequences |
R1067 |
T3682 |
T3680 |
compound |
target,sequences |
R1068 |
T3683 |
T3684 |
punct |
[,19 |
R1069 |
T3684 |
T3676 |
parataxis |
19,bind |
R1070 |
T3685 |
T3684 |
nummod |
17,19 |
R1071 |
T3686 |
T3684 |
punct |
",",19 |
R1072 |
T3687 |
T3684 |
nummod |
18,19 |
R1073 |
T3688 |
T3684 |
punct |
",",19 |
R1074 |
T3689 |
T3684 |
punct |
],19 |
R1075 |
T3690 |
T3652 |
punct |
.,constitute |
R1076 |
T3692 |
T3693 |
advmod |
Nevertheless,rescue |
R1077 |
T3694 |
T3693 |
punct |
", ",rescue |
R1078 |
T3695 |
T3696 |
advmod |
when,introduced |
R1079 |
T3696 |
T3693 |
advcl |
introduced,rescue |
R1080 |
T3697 |
T3696 |
prep |
into,introduced |
R1081 |
T3698 |
T3699 |
det |
the,locus |
R1082 |
T3699 |
T3697 |
pobj |
locus,into |
R1083 |
T3700 |
T3699 |
compound |
Er81,locus |
R1084 |
T3701 |
T3696 |
prep |
in,introduced |
R1085 |
T3702 |
T3701 |
pobj |
analogy,in |
R1086 |
T3703 |
T3702 |
prep |
to,analogy |
R1087 |
T3704 |
T3705 |
det |
a,strategy |
R1088 |
T3705 |
T3703 |
pobj |
strategy,to |
R1089 |
T3706 |
T3707 |
advmod |
previously,used |
R1090 |
T3707 |
T3705 |
amod |
used,strategy |
R1091 |
T3708 |
T3705 |
compound |
targeting,strategy |
R1092 |
T3709 |
T3710 |
punct |
(,shown |
R1093 |
T3710 |
T3696 |
parataxis |
shown,introduced |
R1094 |
T3711 |
T3710 |
nsubj |
data,shown |
R1095 |
T3712 |
T3710 |
neg |
not,shown |
R1096 |
T3713 |
T3710 |
punct |
;,shown |
R1097 |
T3714 |
T3715 |
punct |
[,14 |
R1098 |
T3715 |
T3710 |
parataxis |
14,shown |
R1099 |
T3716 |
T3715 |
punct |
],14 |
R1100 |
T3717 |
T3710 |
punct |
),shown |
R1101 |
T3718 |
T3693 |
punct |
", ",rescue |
R1102 |
T3719 |
T3720 |
preconj |
neither,Pea3 |
R1103 |
T3720 |
T3693 |
nsubj |
Pea3,rescue |
R1104 |
T3721 |
T3720 |
cc |
nor,Pea3 |
R1105 |
T3722 |
T3720 |
conj |
Erm,Pea3 |
R1106 |
T3723 |
T3693 |
aux |
could,rescue |
R1107 |
T3724 |
T3725 |
npadvmod |
Ia,proprioceptive |
R1108 |
T3725 |
T3726 |
amod |
proprioceptive,projections |
R1109 |
T3726 |
T3693 |
dobj |
projections,rescue |
R1110 |
T3727 |
T3726 |
amod |
afferent,projections |
R1111 |
T3728 |
T3729 |
aux |
to,invade |
R1112 |
T3729 |
T3693 |
advcl |
invade,rescue |
R1113 |
T3730 |
T3729 |
advmod |
extensively,invade |
R1114 |
T3731 |
T3732 |
det |
the,horn |
R1115 |
T3732 |
T3729 |
dobj |
horn,invade |
R1116 |
T3733 |
T3732 |
amod |
ventral,horn |
R1117 |
T3734 |
T3732 |
prep |
of,horn |
R1118 |
T3735 |
T3736 |
det |
the,cord |
R1119 |
T3736 |
T3734 |
pobj |
cord,of |
R1120 |
T3737 |
T3736 |
amod |
spinal,cord |
R1121 |
T3738 |
T3739 |
punct |
(,shown |
R1122 |
T3739 |
T3729 |
parataxis |
shown,invade |
R1123 |
T3740 |
T3739 |
nsubj |
data,shown |
R1124 |
T3741 |
T3739 |
neg |
not,shown |
R1125 |
T3742 |
T3739 |
punct |
),shown |
R1126 |
T3743 |
T3693 |
punct |
.,rescue |
R1127 |
T3745 |
T3746 |
det |
These,findings |
R1128 |
T3746 |
T3747 |
nsubj |
findings,prompted |
R1129 |
T3748 |
T3747 |
dobj |
us,prompted |
R1130 |
T3749 |
T3750 |
aux |
to,analyze |
R1131 |
T3750 |
T3747 |
xcomp |
analyze,prompted |
R1132 |
T3751 |
T3750 |
dobj |
mice,analyze |
R1133 |
T3752 |
T3753 |
prep |
in,integrated |
R1134 |
T3753 |
T3751 |
relcl |
integrated,mice |
R1135 |
T3754 |
T3752 |
pobj |
which,in |
R1136 |
T3755 |
T3753 |
nsubj |
we,integrated |
R1137 |
T3756 |
T3757 |
compound |
EWS,Pea3 |
R1138 |
T3757 |
T3753 |
dobj |
Pea3,integrated |
R1139 |
T3758 |
T3757 |
punct |
-,Pea3 |
R1140 |
T3759 |
T3757 |
punct |
", ",Pea3 |
R1141 |
T3760 |
T3761 |
det |
a,product |
R1142 |
T3761 |
T3757 |
appos |
product,Pea3 |
R1143 |
T3762 |
T3763 |
compound |
break,point |
R1144 |
T3763 |
T3761 |
compound |
point,product |
R1145 |
T3764 |
T3763 |
punct |
-,point |
R1146 |
T3765 |
T3761 |
compound |
fusion,product |
R1147 |
T3766 |
T3761 |
prep |
between,product |
R1148 |
T3767 |
T3768 |
det |
the,domain |
R1149 |
T3768 |
T3766 |
pobj |
domain,between |
R1150 |
T3769 |
T3770 |
npadvmod |
amino,terminal |
R1151 |
T3770 |
T3768 |
amod |
terminal,domain |
R1152 |
T3771 |
T3770 |
punct |
-,terminal |
R1153 |
T3772 |
T3768 |
prep |
of,domain |
R1154 |
T3773 |
T3774 |
det |
the,gene |
R1155 |
T3774 |
T3772 |
pobj |
gene,of |
R1156 |
T3775 |
T3776 |
nmod |
Ewing,sarcoma |
R1157 |
T3776 |
T3774 |
nmod |
sarcoma,gene |
R1158 |
T3777 |
T3776 |
punct |
(,sarcoma |
R1159 |
T3778 |
T3776 |
appos |
EWS,sarcoma |
R1160 |
T3779 |
T3774 |
punct |
),gene |
R1161 |
T3780 |
T3768 |
cc |
and,domain |
R1162 |
T3781 |
T3782 |
det |
the,domain |
R1163 |
T3782 |
T3768 |
conj |
domain,domain |
R1164 |
T3783 |
T3784 |
compound |
Pea3,DNA |
R1165 |
T3784 |
T3785 |
npadvmod |
DNA,binding |
R1166 |
T3785 |
T3782 |
amod |
binding,domain |
R1167 |
T3786 |
T3787 |
punct |
[,21 |
R1168 |
T3787 |
T3782 |
parataxis |
21,domain |
R1169 |
T3788 |
T3787 |
nummod |
20,21 |
R1170 |
T3789 |
T3787 |
punct |
",",21 |
R1171 |
T3790 |
T3787 |
punct |
],21 |
R1172 |
T3791 |
T3753 |
punct |
", ",integrated |
R1173 |
T3792 |
T3753 |
prep |
into,integrated |
R1174 |
T3793 |
T3794 |
det |
the,locus |
R1175 |
T3794 |
T3792 |
pobj |
locus,into |
R1176 |
T3795 |
T3794 |
compound |
Er81,locus |
R1177 |
T3796 |
T3797 |
punct |
(,Figure |
R1178 |
T3797 |
T3753 |
parataxis |
Figure,integrated |
R1179 |
T3798 |
T3797 |
nummod |
1,Figure |
R1180 |
T3799 |
T3797 |
punct |
),Figure |
R1181 |
T3800 |
T3747 |
punct |
.,prompted |
R1182 |
T3802 |
T3803 |
nsubj |
We,found |
R1183 |
T3804 |
T3805 |
mark |
that,showed |
R1184 |
T3805 |
T3803 |
ccomp |
showed,found |
R1185 |
T3806 |
T3805 |
prep |
in,showed |
R1186 |
T3807 |
T3808 |
det |
a,assay |
R1187 |
T3808 |
T3806 |
pobj |
assay,in |
R1188 |
T3809 |
T3810 |
compound |
luciferase,enzyme |
R1189 |
T3810 |
T3812 |
npadvmod |
enzyme,based |
R1190 |
T3811 |
T3810 |
punct |
-,enzyme |
R1191 |
T3812 |
T3808 |
amod |
based,assay |
R1192 |
T3813 |
T3812 |
punct |
-,based |
R1193 |
T3814 |
T3815 |
compound |
cell,culture |
R1194 |
T3815 |
T3808 |
compound |
culture,assay |
R1195 |
T3816 |
T3808 |
compound |
transfection,assay |
R1196 |
T3817 |
T3805 |
punct |
", ",showed |
R1197 |
T3818 |
T3819 |
compound |
EWS,Pea3 |
R1198 |
T3819 |
T3805 |
nsubj |
Pea3,showed |
R1199 |
T3820 |
T3819 |
punct |
-,Pea3 |
R1200 |
T3821 |
T3822 |
amod |
stronger,activity |
R1201 |
T3822 |
T3805 |
dobj |
activity,showed |
R1202 |
T3823 |
T3822 |
compound |
transactivation,activity |
R1203 |
T3824 |
T3822 |
prep |
than,activity |
R1204 |
T3825 |
T3824 |
pobj |
Er81,than |
R1205 |
T3826 |
T3825 |
cc |
or,Er81 |
R1206 |
T3827 |
T3825 |
conj |
Pea3,Er81 |
R1207 |
T3828 |
T3829 |
punct |
(,1J |
R1208 |
T3829 |
T3822 |
parataxis |
1J,activity |
R1209 |
T3830 |
T3829 |
compound |
Figure,1J |
R1210 |
T3831 |
T3829 |
punct |
;,1J |
R1211 |
T3832 |
T3833 |
nsubj |
data,shown |
R1212 |
T3833 |
T3829 |
ccomp |
shown,1J |
R1213 |
T3834 |
T3833 |
neg |
not,shown |
R1214 |
T3835 |
T3829 |
punct |
),1J |
R1215 |
T3836 |
T3805 |
punct |
", ",showed |
R1216 |
T3837 |
T3805 |
prep |
in,showed |
R1217 |
T3838 |
T3837 |
pobj |
agreement,in |
R1218 |
T3839 |
T3838 |
prep |
with,agreement |
R1219 |
T3840 |
T3841 |
amod |
previous,studies |
R1220 |
T3841 |
T3839 |
pobj |
studies,with |
R1221 |
T3842 |
T3843 |
punct |
[,24 |
R1222 |
T3843 |
T3841 |
parataxis |
24,studies |
R1223 |
T3844 |
T3843 |
nummod |
22,24 |
R1224 |
T3845 |
T3843 |
punct |
",",24 |
R1225 |
T3846 |
T3843 |
nummod |
23,24 |
R1226 |
T3847 |
T3843 |
punct |
",",24 |
R1227 |
T3848 |
T3843 |
punct |
],24 |
R1228 |
T3849 |
T3803 |
punct |
.,found |
R1229 |
T3851 |
T3852 |
advmod |
Moreover,abolished |
R1230 |
T3853 |
T3852 |
punct |
", ",abolished |
R1231 |
T3854 |
T3852 |
nsubjpass |
transactivation,abolished |
R1232 |
T3855 |
T3854 |
prep |
by,transactivation |
R1233 |
T3856 |
T3857 |
compound |
EWS,Pea3 |
R1234 |
T3857 |
T3855 |
pobj |
Pea3,by |
R1235 |
T3858 |
T3857 |
punct |
-,Pea3 |
R1236 |
T3859 |
T3852 |
auxpass |
was,abolished |
R1237 |
T3860 |
T3852 |
agent |
by,abolished |
R1238 |
T3861 |
T3860 |
pobj |
mutation,by |
R1239 |
T3862 |
T3861 |
prep |
of,mutation |
R1240 |
T3863 |
T3864 |
npadvmod |
ETS,binding |
R1241 |
T3864 |
T3866 |
amod |
binding,sites |
R1242 |
T3865 |
T3864 |
punct |
-,binding |
R1243 |
T3866 |
T3862 |
pobj |
sites,of |
R1244 |
T3867 |
T3861 |
prep |
in,mutation |
R1245 |
T3868 |
T3869 |
det |
the,plasmid |
R1246 |
T3869 |
T3867 |
pobj |
plasmid,in |
R1247 |
T3870 |
T3869 |
compound |
reporter,plasmid |
R1248 |
T3871 |
T3852 |
punct |
", ",abolished |
R1249 |
T3872 |
T3852 |
advcl |
demonstrating,abolished |
R1250 |
T3873 |
T3874 |
npadvmod |
ETS,binding |
R1251 |
T3874 |
T3876 |
amod |
binding,site |
R1252 |
T3875 |
T3874 |
punct |
-,binding |
R1253 |
T3876 |
T3878 |
compound |
site,dependence |
R1254 |
T3877 |
T3876 |
punct |
-,site |
R1255 |
T3878 |
T3872 |
dobj |
dependence,demonstrating |
R1256 |
T3879 |
T3880 |
punct |
(,shown |
R1257 |
T3880 |
T3872 |
parataxis |
shown,demonstrating |
R1258 |
T3881 |
T3880 |
nsubj |
data,shown |
R1259 |
T3882 |
T3880 |
neg |
not,shown |
R1260 |
T3883 |
T3880 |
punct |
),shown |
R1261 |
T3884 |
T3852 |
punct |
.,abolished |