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{"project":"2_test","denotations":[{"id":"15836427-12123609-84719686","span":{"begin":233,"end":235},"obj":"12123609"},{"id":"T58840","span":{"begin":233,"end":235},"obj":"12123609"}],"text":"Western blot analysis\nLumbar DRG from E16.5 embryos were isolated, mechanically disrupted, homogenized using glass beads (Sigma), and lysed in standard lysis buffer supplemented with protease and phosphatase inhibitors as described [47]. Protein extracts were resolved by SDS-PAGE, and immunoblotting was performed using antibodies against Akt, p-Akt (Ser473), CREB, p-CREB (Ser133), Bax, Bcl-xl (Cell Signaling Technology, Beverly, Massachusetts, United States), and Bcl2 (BD Pharmingen, San Diego, California, United States). For quantification, films (X-OMAT AR, Eastman Kodak, Rochester, New York, United States) were scanned and densitometry was performed using IMAGEQUANT 5.2 (Molecular Dynamics, Amersham, Uppsala, Sweden)."}

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blot analysis\nLumbar DRG from E16.5 embryos were isolated, mechanically disrupted, homogenized using glass beads (Sigma), and lysed in standard lysis buffer supplemented with protease and phosphatase inhibitors as described [47]. Protein extracts were resolved by SDS-PAGE, and immunoblotting was performed using antibodies against Akt, p-Akt (Ser473), CREB, p-CREB (Ser133), Bax, Bcl-xl (Cell Signaling Technology, Beverly, Massachusetts, United States), and Bcl2 (BD Pharmingen, San Diego, California, United States). For quantification, films (X-OMAT AR, Eastman Kodak, Rochester, New York, United States) were scanned and densitometry was performed using IMAGEQUANT 5.2 (Molecular Dynamics, Amersham, Uppsala, Sweden)."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T14722","span":{"begin":22,"end":32},"obj":"UBERON:0002836"},{"id":"T14723","span":{"begin":44,"end":51},"obj":"UBERON:0000922"},{"id":"T14724","span":{"begin":134,"end":139},"obj":"GO:0019835"},{"id":"T14725","span":{"begin":152,"end":157},"obj":"GO:0019835"},{"id":"T14726","span":{"begin":272,"end":275},"obj":"CHEBI:8984"},{"id":"T14727","span":{"begin":321,"end":331},"obj":"GO:0042571"},{"id":"T14728","span":{"begin":340,"end":343},"obj":"PR:000029189"},{"id":"T14729","span":{"begin":347,"end":350},"obj":"PR:000029189"},{"id":"T14730","span":{"begin":384,"end":387},"obj":"PR:000002193"},{"id":"T14731","span":{"begin":389,"end":395},"obj":"PR:000002385"},{"id":"T14732","span":{"begin":468,"end":472},"obj":"PR:000002307"}],"text":"Western blot analysis\nLumbar DRG from E16.5 embryos were isolated, mechanically disrupted, homogenized using glass beads (Sigma), and lysed in standard lysis buffer supplemented with protease and phosphatase inhibitors as described [47]. Protein extracts were resolved by SDS-PAGE, and immunoblotting was performed using antibodies against Akt, p-Akt (Ser473), CREB, p-CREB (Ser133), Bax, Bcl-xl (Cell Signaling Technology, Beverly, Massachusetts, United States), and Bcl2 (BD Pharmingen, San Diego, California, United States). For quantification, films (X-OMAT AR, Eastman Kodak, Rochester, New York, United States) were scanned and densitometry was performed using IMAGEQUANT 5.2 (Molecular Dynamics, Amersham, Uppsala, Sweden)."}